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Aliases for ADRA1D Gene

Aliases for ADRA1D Gene

  • Adrenoceptor Alpha 1D 2 3
  • ADRA1A 3 4 6
  • Adrenergic, Alpha-1D-, Receptor 2 3
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-Adrenergic Receptor 1a 3 4
  • Alpha-1D Adrenoreceptor 3 4
  • Alpha-1D Adrenoceptor 3 4
  • Adrenergic, Alpha -1D-, Receptor 3
  • Adrenergic, Alpha-1A-, Receptor 3
  • Alpha-1D Adrenergic Receptor 3
  • Alpha-1D-Adrenergic Receptor 3
  • DJ779E11.2 3
  • ADRA1R 3
  • ALPHA1 3
  • ADRA1 3
  • DAR 3

External Ids for ADRA1D Gene

Previous GeneCards Identifiers for ADRA1D Gene

  • GC20M004189
  • GC20M004196
  • GC20M004149

Summaries for ADRA1D Gene

Entrez Gene Summary for ADRA1D Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1D Gene

ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include impotence. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1D Gene

  • This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

Tocris Summary for ADRA1D Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1D Gene

Genomics for ADRA1D Gene

Regulatory Elements for ADRA1D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRA1D Gene

4,220,631 bp from pter
4,249,074 bp from pter
28,444 bases
Minus strand

Genomic View for ADRA1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1D Gene

Proteins for ADRA1D Gene

  • Protein details for ADRA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1D adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • Q9NPY0

    Protein attributes for ADRA1D Gene

    572 amino acids
    Molecular mass:
    60463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADRA1D Gene

Proteomics data for ADRA1D Gene at MOPED

Post-translational modifications for ADRA1D Gene

  • Glycosylation at Asn65 and Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADRA1D Gene

Domains for ADRA1D Gene

Gene Families for ADRA1D Gene

Suggested Antigen Peptide Sequences for ADRA1D Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
genes like me logo Genes that share domains with ADRA1D: view

Function for ADRA1D Gene

Molecular function for ADRA1D Gene

GENATLAS Biochemistry:
adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphadidylinositol/Ca2+ second messenger system
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

Gene Ontology (GO) - Molecular Function for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004937 alpha1-adrenergic receptor activity IEA --
genes like me logo Genes that share ontologies with ADRA1D: view
genes like me logo Genes that share phenotypes with ADRA1D: view

Animal Models for ADRA1D Gene

MGI Knock Outs for ADRA1D:

Animal Model Products

miRNA for ADRA1D Gene

miRTarBase miRNAs that target ADRA1D

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA1D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADRA1D Gene

Localization for ADRA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADRA1D Gene COMPARTMENTS Subcellular localization image for ADRA1D gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7746284
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA1D: view

Pathways for ADRA1D Gene

genes like me logo Genes that share pathways with ADRA1D: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001986 negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0006259 DNA metabolic process TAS 10969806
GO:0007186 G-protein coupled receptor signaling pathway TAS 1656955
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 10820200
genes like me logo Genes that share ontologies with ADRA1D: view

Drugs for ADRA1D Gene

(46) Drugbank Compounds for ADRA1D Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 1-phenyl-2-aminopropane
300-62-9 Target agonist approved, illicit
  • (±)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furamide
81403-80-7 2092 Target antagonist approved, investigational
  • (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
25614-03-3 31101 Target agonist approved, investigational
  • (+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol
72956-09-3 2585 Target antagonist approved, investigational
  • Dops
23651-95-8 443940 Target agonist approved, investigational

(5) Tocris Compounds for ADRA1D Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist [61-76-7]
A 61603 hydrobromide alpha1A agonist [107756-30-9]
Cirazoline hydrochloride Selective alpha1 agonist [40600-13-3]
Naftopidil hydrochloride alpha1 antagonist [1164469-60-6]
RS 17053 hydrochloride alpha1A antagonist [169505-93-5]

(57) ApexBio Compounds for ADRA1D Gene

Compound Action Cas Number
Acebutolol HCl [34381-68-5]
Adrenalone HCl [62-13-5]
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective [81403-68-1]
Bambuterol [81732-65-2]
Betaxolol βadrenergic receptor blocker [659-18-7]
Betaxolol HCl [63659-19-8]
Bisoprolol fumarate [104344-23-2]
Brimonidine Tartrate [70359-46-5]
Carvedilol [72956-09-3]
Cisatracurium Besylate Neuromuscular-blocking drug [96946-42-8]
Clonidine HCl [4205-91-8]
Detomidine HCl [90038-01-0]
Dexmedetomidine [113775-47-6]
Dexmedetomidine HCl [145108-58-3]
DL-Adrenaline [329-65-7]
Doxazosin Mesylate α1-adrenergic receptor antagonist [77883-43-3]
Droxidopa [23651-95-8]
Epinephrine Bitartrate [51-42-3]
Epinephrine HCl [55-31-2]
Formoterol Hemifumarate [43229-80-7]
Guanabenz Acetate [23256-50-0]
Indacaterol Maleate [753498-25-8]
Isoprenaline HCl [51-30-9]
Ivabradine HCl [148849-67-6]
Labetalol HCl [32780-64-6]
L-Adrenaline [51-43-4]
Maprotiline HCl [10347-81-6]
Medetomidine HCl [86347-15-1]
Methyldopa [555-30-6]
Metoprolol Tartrate β1-adrenergic blocking agent [392-17-7]
Mirabegron (YM178) [223673-61-8]
Naftopidil α1-adrenergic receptor antagonist [57149-07-2]
Naftopidil DiHCl [57149-08-3]
Naphazoline HCl [550-99-2]
Nebivolol [152520-56-4]
Nedaplatin [95734-82-0]
Noradrenaline bitartrate monohydrate [108341-18-0]
Oxymetazoline HCl Alpha-1/alpha-2 agonist [2315-2-8]
Phenoxybenzamine HCl [63-92-3]
Phentolamine Mesylate Alpha 1/2-blocking agent [65-28-1]
Phenylephrine HCl [61-76-7]
Prazosin HCl α1 and α2B-adrenoceptor antagonist [19237-84-4]
Propranolol HCl [318-98-9]
Ritodrine HCl β-2 adrenergic receptor agonist [23239-51-2]
Salbutamol Sulfate β-2 adrenergic receptor agonist [51022-70-9]
Salmeterol xinafoate β2-adrenergic receptor agonist [94749-08-3]
Scopine [498-45-3]
Silodosin α1-adrenoceptor antagonist [160970-54-7]
Synephrine HCl [5985-28-4]
Terazosin HCl [70024-40-7]
Terbutaline Sulfate [23031-32-5]
Tetrahydrozoline HCl [522-48-5]
Timolol Maleate [26921-17-5]
Tizanidine HCl [64461-82-1]
Tolazoline HCl [59-97-2]
Xylazine HCl α2 Adrenoceptor agonist [23076-35-9]
Xylometazoline HCl [1218-35-5]

(20) HMDB Compounds for ADRA1D Gene

Compound Synonyms Cas Number PubMed IDs
  • Alfusosine
  • Bromergocryptine
  • Ca
  • Doxazosin mesilate

(35) IUPHAR Ligand for ADRA1D Gene

Ligand Type Action Affinity Pubmed IDs
tamsulosin Antagonist Antagonist 10.7
silodosin Antagonist Antagonist 10.4
cyproheptadine Antagonist Antagonist 10.2
(+)-niguldipine Antagonist Antagonist 10
[125I]HEAT Agonist Full agonist 10
prazosin Antagonist Inverse agonist 9.9
[125I]BE-2254 Antagonist Antagonist 9.9
WB 4101 Antagonist Antagonist 9.8
Rec 15/2739 Antagonist Antagonist 9.6
RS-100329 Antagonist Antagonist 9.6
NAN 190 Antagonist Antagonist 9.4
RS-17053 Antagonist Antagonist 9.3
5-methylurapidil Antagonist Antagonist 9.2
Ro-70-0004 Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
A-119637 Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
indoramin Antagonist Antagonist 8.4
A-123189 Antagonist Antagonist 8.4
BMY-7378 Agonist Partial agonist 8
(+)-cyclazosin Antagonist Antagonist 7.9
risperidone Antagonist Antagonist 7.8
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
SKF 105854 Antagonist Antagonist 7.1
oxymetazoline Agonist Full agonist 6.8
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
ketanserin Inhibitor Inhibition 6.3
(-)-adrenaline Agonist Full agonist 6.2
NS-49 Agonist Partial agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
alpha-methylnoradrenaline Agonist Full agonist 5.6
methoxamine Agonist Full agonist 5.2
(+)-adrenaline Agonist Full agonist 5

(4) Novoseek inferred chemical compound relationships for ADRA1D Gene

Compound -log(P) Hits PubMed IDs
bmy7378 79.3 1
tamsulosin 67.2 1
norepinephrine 48.7 1
phenylephrine 35.4 1
genes like me logo Genes that share compounds with ADRA1D: view

Transcripts for ADRA1D Gene

mRNA/cDNA for ADRA1D Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1D Gene

Adrenoceptor alpha 1D:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA1D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1D Gene

No ASD Table

Relevant External Links for ADRA1D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA1D Gene

mRNA expression in normal human tissues for ADRA1D Gene

mRNA differential expression in normal tissues according to GTEx for ADRA1D Gene

This gene is overexpressed in Artery - Aorta (5.5), Brain - Hippocampus (4.4), and Cervix - Ectocervix (4.3).

Protein differential expression in normal tissues for ADRA1D Gene

This gene is overexpressed in Cervix (55.6) and Kidney (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADRA1D Gene

SOURCE GeneReport for Unigene cluster for ADRA1D Gene Hs.557

genes like me logo Genes that share expressions with ADRA1D: view

Expression partners for ADRA1D Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADRA1D Gene

Orthologs for ADRA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADRA1D 35
  • 82.33 (n)
  • 81.14 (a)
  • 82 (a)
(Mus musculus)
Mammalia Adra1d 35
  • 82.27 (n)
  • 84.34 (a)
Adra1d 16
Adra1d 36
  • 86 (a)
(Pan troglodytes)
Mammalia ADRA1D 35
  • 97.85 (n)
  • 97.14 (a)
(Rattus norvegicus)
Mammalia Adra1d 35
  • 81.94 (n)
  • 84.31 (a)
(Canis familiaris)
Mammalia ADRA1D 36
  • 94 (a)
(Monodelphis domestica)
Mammalia ADRA1D 36
  • 80 (a)
(Gallus gallus)
Aves ADRA1D 35
  • 68.35 (n)
  • 63.56 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia ADRA1D 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495969 35
  • 66.05 (n)
  • 63.58 (a)
(Danio rerio)
Actinopterygii LOC568614 35
  • 61.77 (n)
  • 61.56 (a)
adra1d 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 34 (a)
5-HT1B 37
  • 38 (a)
CG6919 37
  • 34 (a)
CG6989 37
  • 33 (a)
CG7431 37
  • 44 (a)
DopR 37
  • 36 (a)
DopR2 37
  • 45 (a)
Oamb 37
  • 53 (a)
Oamb 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea dop-4 36
  • 25 (a)
Species with no ortholog for ADRA1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1D Gene

Gene Tree for ADRA1D (if available)
Gene Tree for ADRA1D (if available)

Paralogs for ADRA1D Gene

Paralogs for ADRA1D Gene

(16) SIMAP similar genes for ADRA1D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADRA1D: view

Variants for ADRA1D Gene

Sequence variations from dbSNP and Humsavar for ADRA1D Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs58435249 -- 4,237,091(+) TTGTC(A/T)GGAAA intron-variant
rs58193701 -- 4,250,381(+) TGGGG(C/T)TGGTA upstream-variant-2KB
rs58035804 -- 4,231,064(+) TTTCT(-/TTCT)CTCTC intron-variant
rs57992348 -- 4,223,096(+) TTTTT(-/T)AGACC intron-variant
rs57799061 -- 4,237,435(+) TTATT(C/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1D Gene

Variant ID Type Subtype PubMed ID
esv2722127 CNV Deletion 23290073
esv2722129 CNV Deletion 23290073
nsv178938 CNV Loss 16902084
esv2722130 CNV Deletion 23290073
nsv180352 CNV Loss 16902084
nsv833901 CNV Gain 17160897
esv2661469 CNV Deletion 23128226

Relevant External Links for ADRA1D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1D Gene

Disorders for ADRA1D Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADRA1D Gene in MalaCards »

(1) Disease for ADRA1D Gene

(4) University of Copenhagen DISEASES for ADRA1D Gene

(3) Novoseek inferred disease relationships for ADRA1D Gene

Disease -log(P) Hits PubMed IDs
benign prostatic hyperplasia 43.8 1
essential hypertension 32.3 2
obstruction 0 1

Relevant External Links for ADRA1D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADRA1D: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADRA1D Gene

Publications for ADRA1D Gene

  1. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PMID: 18187928) Nagaoka Y. … Nagatomo T. (J. Pharmacol. Sci. 2008) 3 23 25 26
  2. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PMID: 12442007) Sugaya K. … Ogawa Y. (J. Urol. 2002) 3 23 48
  3. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PMID: 7746284) Esbenshade T.A. … Murphy T.J. (Mol. Pharmacol. 1995) 3 4 23
  4. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. (PMID: 17404580) Nonen S. … Azuma J. (Pharmacogenomics J. 2008) 3 23 48
  5. Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms. (PMID: 15639685) Lowe F.C. (Clin Ther 2004) 23 25 26

Products for ADRA1D Gene

Sources for ADRA1D Gene

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