Aliases for ADRA1D Gene
External Ids for ADRA1D Gene
Previous GeneCards Identifiers for ADRA1D Gene
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA1D Gene
ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include impotence. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for ADRA1D Gene
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.