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ADRA1D Gene

protein-coding   GIFtS: 64
GCID: GC20M004149

Adrenoceptor Alpha 1D

(Previous names: adrenergic, alpha-1D-, receptor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 1D1 2     ADRA1R2
ADRA1A2 3 5     ALPHA12
Adrenergic, Alpha-1D-, Receptor1 2     DAR2
Alpha-1A Adrenergic Receptor2 3     Adrenergic, Alpha -1D-, Receptor2
Alpha-1D Adrenoceptor2 3     Adrenergic, Alpha-1A-, Receptor2
Alpha-1D Adrenoreceptor2 3     Alpha-1D Adrenergic Receptor2
Alpha-Adrenergic Receptor 1a2 3     Alpha-1D-Adrenergic Receptor2
ADRA12     dJ779E11.22

External Ids:    HGNC: 2801   Entrez Gene: 1462   Ensembl: ENSG000001718737   OMIM: 1042195   UniProtKB: P251003   

Export aliases for ADRA1D gene to outside databases

Previous GC identifers: GC20M004189 GC20M004196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA1D Gene:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They
activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR
subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different
subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to
alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding
region. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA1D Gene:
ADRA1D (adrenoceptor alpha 1D) is a protein-coding gene. Diseases associated with ADRA1D include prostatic hypertrophy, and impotence. GO annotations related to this gene include alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100
Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

summary for ADRA1D Gene:
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The
adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.
lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in
smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L
based on its low affinity for prazosin. It has been suggested that this subtype may represent a different
conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1D (Alpha-1D adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA1D gene promoter:
         SRF   PPAR-gamma1   SRF (504 AA)   Nkx2-5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADRA1D promoter sequence
   Search Chromatin IP Primers for ADRA1D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

ADRA1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA1D gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M004149:  view genomic region     (about GC identifiers)

Start:
4,201,278 bp from pter      End:
4,229,721 bp from pter
Size:
28,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100 (See protein sequence)
Recommended Name: Alpha-1D adrenergic receptor  
Size: 572 amino acids; 60463 Da
Secondary accessions: Q9NPY0

Explore the universe of human proteins at neXtProt for ADRA1D: NX_P25100

Explore proteomics data for ADRA1D at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn82

  • See ADRA1D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000669.1  
    ENSEMBL proteins: 
     ENSP00000368766  
    Reactome Protein details: P25100

    ADRA1D Human Recombinant Protein Products:

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    Abcam antibodies for ADRA1D (P25100, P35348)
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    ADRA1D Assay Products:

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    GenScript ADRA1D-overexpressing Cell Line for Assay
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha1D-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR000363 ADRA1D_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25100

    ProtoNet protein and cluster: P25100

    2 Blocks protein domains:
    IPB000363 Alpha-1A adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA1D_HUMAN, P25100
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D
    sub-subfamily


    ADRA1D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA1D_HUMAN, P25100
    Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

         Genatlas biochemistry entry for ADRA1D:
    adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the
    phosphadidylinositol/Ca2+ second messenger system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004937alpha1-adrenergic receptor activity IEA--
         
    ADRA1D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADRA1D:
     Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adra1d):
     behavior/neurological  cardiovascular system  muscle  nervous system 

    ADRA1D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adra1dtm1Gzt for ADRA1D

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRA1D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADRA1D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA1D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRA1D

    miRNA
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    miRTarBase miRNAs that target ADRA1D:
    hsa-mir-484 (MIRT041983)

    Block miRNA regulation of human, mouse, rat ADRA1D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRA1D (see all 19):
    hsa-miR-30c hsa-miR-4311 hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-759 hsa-miR-373* hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidADRA1D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADRA1D
    Predesigned siRNA for gene silencing in human, mouse, rat ADRA1D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADRA1D

    Clone
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    OriGene clones in human, mouse for ADRA1D (see all 5)
    OriGene ORF clones in mouse, rat for ADRA1D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADRA1D (NM_000678)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA1D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRA1D

    Cell Line
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    GenScript ADRA1D-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADRA1D 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA1D_HUMAN, P25100: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7746284
    GO:0016021integral component of membrane ----

    ADRA1D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA1D About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA1D
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 GeneGo (Thomson Reuters) Pathways for ADRA1D
        Development Activation of ERK by Alpha-1 adrenergic receptors
    Translation Translation regulation by Alpha-1 adrenergic receptors

    4 BioSystems Pathways for ADRA1D
        Calcium Regulation in the Cardiac Cell
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    3 Reactome Pathways for ADRA1D
        G alpha (12/13) signalling events
    G alpha (q) signalling events
    Adrenoceptors

    2 PharmGKB Pathways for ADRA1D
        Antiarrhythmic Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    5 Kegg Pathways  (Kegg details for ADRA1D):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Salivary secretion


    ADRA1D for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA1D: 
              Neurotransmitter Receptors in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRA1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRA1D (P251003 ENSP000003687664) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    SNTA1Q134243, ENSP000002173814I2D: score=2 STRING: ENSP00000217381
    ADRA1AP353483, ENSP000003699604I2D: score=1 STRING: ENSP00000369960
    SNTB1Q138843, ENSP000003789654I2D: score=1 STRING: ENSP00000378965
    FLNCQ143153, ENSP000003271454I2D: score=2 STRING: ENSP00000327145
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001986negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure IEA--
    GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA--
    GO:0006259DNA metabolic process TAS10969806
    GO:0007186G-protein coupled receptor signaling pathway TAS1656955
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS10820200

    ADRA1D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADRA1D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 100329 hydrochloride Potent, subtype-selective alpha1A antagonist [232953-52-5]
    RS 17053 hydrochloridealpha1A antagonist[169505-93-5]
    Cirazoline hydrochlorideSelective alpha1 agonist[40600-13-3]
    (R)-(-)-Phenylephrine hydrochloridealpha1 agonist[61-76-7]
    A 61603 hydrobromidealpha1A agonist[107756-30-9]

    1 HMDB Compound for ADRA1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for ADRA1D (see all 26)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alfuzosin-- 81403-80-7targetantagonist9122046 15639685 11750253 11752352 16553574 8196478 16613526 8799556
    NorepinephrineArterenol (see all 4)51-41-2targetagonist17266602 18064417 17139284 7582530 17016423 15451776 7674815
    Tamsulosin-- 106133-20-4targetantagonist9117115 16986050 16518087 11752352 14680444 8996174 12270758
    DoxazosinDoxazosin mesilate (see all 2)74191-85-8targetantagonist18231614 19002123 10393471 17070143
    DroxidopaDroxydopa (see all 4)23651-95-8targetagonist17266602 7582530 20412040 7674815
    EpinephrineADR Adrenaline (see all 25)51-43-4targetantagonist20954794 19730427 20412040 20857090
    Doxepin-- 1668-19-5targetantagonist7855217 19179941 6086881
    PrazosinPrazocin (see all 6)19216-56-9targetantagonist18187928 7855217 11682453
    Dapiprazole-- 72822-12-9targetantagonist17139284 17016423
    Methotrimeprazine-- 60-99-1targetantagonist2870716 15701205

    Selected IUPHAR Ligands for ADRA1D (alpha1D-adrenoceptor) (see all 35)    About this table
    LigandTypeActionAffinityPubmed IDs
    prazosin
    AntagonistInverse agonist9.5 - 10.27651358 9249248 10369480
    tamsulosin
    AntagonistAntagonist10.27651358
    [125I]BE-2254
    AntagonistAntagonist9.97815325
    A-119637
    AntagonistAntagonist9.611354357
    WB 4101
    AntagonistAntagonist9.69249248 7651358
    A-123189
    AntagonistAntagonist9.511354357
    [125I]HEAT
    AgonistFull agonist9.57651358
    NAN 190
    AntagonistAntagonist9.211459121
    BMY-7378
    AntagonistAntagonist8.7 - 9.111459121 11354357
    silodosin
    AntagonistAntagonist8.77651358

    4 Novoseek inferred chemical compound relationships for ADRA1D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bmy7378 79.3 1 16426068 (1)
    tamsulosin 67.2 1 15639685 (1)
    norepinephrine 48.7 1 17404580 (1)
    phenylephrine 35.4 1 10344211 (1)



    ADRA1D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADRA1D gene: 
    NM_000678.3  

    Unigene Cluster for ADRA1D:

    Adrenoceptor alpha 1D
    Hs.557  [show with all ESTs]
    Unigene Representative Sequence: NM_000678
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379453(uc002wkr.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat ADRA1D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRA1D (see all 19):
    hsa-miR-30c hsa-miR-4311 hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-759 hsa-miR-373* hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidADRA1D 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADRA1D
    Predesigned siRNA for gene silencing in human, mouse, rat ADRA1D
    Clone
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    OriGene clones in human, mouse for ADRA1D (see all 5)
    OriGene ORF clones in mouse, rat for ADRA1D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADRA1D (NM_000678)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA1D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADRA1D
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADRA1D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADRA1D
      QuantiTect SYBR Green Assays in human, mouse, rat ADRA1D
      QuantiFast Probe-based Assays in human, mouse, rat ADRA1D

    Additional mRNA sequence: 

    L31772.1 S70782.1 U03864.1 

    4 DOTS entries:

    DT.442233  DT.92416103  DT.95254294  DT.95357194 

    21 AceView cDNA sequences:

    BX280890 AI457674 AI611270 S70782 L31772 BE439970 CA424283 BI828457 
    CA310090 NM_000678 U03864 M76446 AA809802 AW975996 AW875208 BM546478 
    AW875213 AA909273 AA921964 AW577200 BQ067091 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCGCTGT
    ADRA1D Expression
    About this image

    ADRA1D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA1D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.557
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA1D: 
              Neurotransmitter Receptors in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADRA1D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADRA1D
    QuantiTect SYBR Green Assays in human, mouse, rat ADRA1D
    QuantiFast Probe-based Assays in human, mouse, rat ADRA1D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA1D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra1d1 , 5 adrenergic receptor, alpha 1d1, 5 82.27(n)1
    84.34(a)1
      2 (63.50 cM)5
    115501  NM_013460.41  NP_038488.41 
     1315458505 
    chicken
    (Gallus gallus)
    Aves ADRA1D1 adrenergic, alpha-1D-, receptor 68.35(n)
    63.56(a)
      422933  XM_004936274.1  XP_004936331.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA1D6
    adrenoceptor alpha 1D
    59(a)
    1 ↔ 1
    GL343407.1(158529-236511)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004959691 alpha-1D adrenergic receptor-like 66.05(n)
    63.58(a)
      100495969  XM_002935485.2  XP_002935531.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5686141 alpha-1D adrenergic receptor-like 61.77(n)
    61.56(a)
      568614  XM_691951.3  XP_697043.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oamb3 octopamine/tyramine signaling pathway
    octopamine more
    53(a)
    (best of 8)
      92F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-46
    Protein DOP-4 (dop-4) mRNA, complete cds
    25(a)
    1 → many
    X(1295278-1298658) WBGene00016872


    ENSEMBL Gene Tree for ADRA1D (if available)
    TreeFam Gene Tree for ADRA1D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA1D gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  
    ADRA1A2  HTR1E2  HTR5A2  HTR1B2  
    16 SIMAP similar genes for ADRA1D using alignment to 2 protein entries:     ADA1D_HUMAN (see all proteins):
    ADRA1A    ADRA1B    DRD3    HTR1B    HTR1F    HTR5A
    HTR1D    HTR1E    ADRB3    DRD1    HTR7    5HT1A
    DRD5    HTR1A    HRH2    ADRB1

    ADRA1D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRA1D (see all 731)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617585501,2
    F--4200861(+) TGGTTG/AGAAGT 1 -- ds50011Minor allele frequency- A:0.01NS 562
    rs617585511,2
    C,F--4201033(+) TTCATG/ATAAAC 1 -- ds50011Minor allele frequency- A:0.05NS 564
    rs1809322211,2
    --4201105(+) AAGCAA/TCTGGG 1 -- ds50010--------
    rs7090231,2
    C,F,A,H--4201130(+) GACAAT/ATTGTG 1 -- ds500124Minor allele frequency- A:0.20NS EA NA WA 3322
    rs1843530341,2
    --4201152(+) TATTTA/GGTTCA 1 -- ds50010--------
    rs58400241,2
    C--4201191(+) AACAAC/-CCCCC 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs356972591,2
    C,F--4201192(+) ACAAC-/CCCCCC 1 -- ds50011Minor allele frequency- C:0.00NS 560
    rs617585531,2
    F--4201210(+) CCTTTG/AGTCAT 1 -- ds50011Minor allele frequency- A:0.00NS 552
    rs1891027131,2
    --4201443(+) ACAAAC/TAAAGC 1 -- ut310--------
    rs1820053651,2
    --4201463(+) GGTGGC/TTTGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADRA1D (4201278 - 4229721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ADRA1D:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722129CNV Deletion23290073
    esv2661469CNV Deletion23128226
    esv2722130CNV Deletion23290073
    esv2722127CNV Deletion23290073
    nsv180352CNV Loss16902084
    nsv178938CNV Loss16902084
    nsv833901CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRA1D
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRA1D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104219    OMIM disorders: --

    17 diseases for ADRA1D:    About MalaCards
    prostatic hypertrophy    impotence    gastroparesis    alpha 1-antitrypsin deficiency
    cystitis    essential hypertension    pulmonary function    hypertension
    dilated cardiomyopathy    pre-eclampsia    eclampsia    hyperglycemia
    prostatitis    hypoxia    prostate cancer    endotheliitis
    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for ADRA1D:
    Alpha 1-antitrypsin deficiency     Hypertension     Prostatic hypertrophy     Impotence

    ADRA1D for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ADRA1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benign prostatic hyperplasia 43.8 1 17254786 (1)
    essential hypertension 32.3 3 16685204 (2)
    obstruction 0 1 15112040 (1)

    Genetic Association Database (GAD): ADRA1D
    Human Genome Epidemiology (HuGE) Navigator: ADRA1D (8 documents)

    Export disorders for ADRA1D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA1D gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with ADRA1D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PubMed id 12442007)1, 4, 9 Sugaya K....Ogawa Y. (J. Urol. 2002)
    2. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PubMed id 7746284)1, 2, 9 Esbenshade T.A.... Murphy T.J. (Mol. Pharmacol. 1995)
    3. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PubMed id 18187928)1, 7, 9 Nagaoka Y....Nagatomo T. (J. Pharmacol. Sci. 2008)
    4. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. (PubMed id 17404580)1, 4, 9 Nonen S....Azuma J. (Pharmacogenomics J. 2008)
    5. Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. (PubMed id 21063774)1, 4 Parkman H.P....Krynetskiy E. (Dig. Dis. Sci. 2011)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (PubMed id 7815325)1, 2 Schwinn D.A.... Bailey D.S. (J. Pharmacol. Exp. Ther. 1995)
    10. Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. (PubMed id 8024574)1, 2 Weinberg D.H.... Bayne M. (Biochem. Biophys. Res. Commun. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146 HGNC: 280 AceView: ADRA1D Ensembl:ENSG00000171873 euGenes: HUgn146
    ECgene: ADRA1D Kegg: 146 H-InvDB: ADRA1D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA1D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRA1D gene:
    Search GeneIP for patents involving ADRA1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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