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Aliases for ADRA1D Gene

Aliases for ADRA1D Gene

  • Adrenoceptor Alpha 1D 2 3 5
  • Adrenergic, Alpha-1D-, Receptor 2 3
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-Adrenergic Receptor 1a 3 4
  • Alpha-1D Adrenoreceptor 3 4
  • Alpha-1D Adrenoceptor 3 4
  • ADRA1A 3 4
  • Adrenergic, Alpha -1D-, Receptor 3
  • Adrenergic, Alpha-1A-, Receptor 3
  • Alpha-1D-Adrenergic Receptor 3
  • DJ779E11.2 3
  • ADRA1R 3
  • ALPHA1 3
  • ADRA1 3
  • DAR 3

External Ids for ADRA1D Gene

Previous GeneCards Identifiers for ADRA1D Gene

  • GC20M004189
  • GC20M004196
  • GC20M004149

Summaries for ADRA1D Gene

Entrez Gene Summary for ADRA1D Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1D Gene

ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include hypertension, essential and schizophrenia. Among its related pathways are cGMP-PKG signaling pathway and Calcium signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1D Gene

  • This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Tocris Summary for ADRA1D Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1D Gene

Genomics for ADRA1D Gene

Regulatory Elements for ADRA1D Gene

Enhancers for ADRA1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADRA1D on UCSC Golden Path with GeneCards custom track

Promoters for ADRA1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRA1D on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA1D Gene

Chromosome:
20
Start:
4,220,631 bp from pter
End:
4,249,074 bp from pter
Size:
28,444 bases
Orientation:
Minus strand

Genomic View for ADRA1D Gene

Genes around ADRA1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1D Gene

Proteins for ADRA1D Gene

  • Protein details for ADRA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25100-ADA1D_HUMAN
    Recommended name:
    Alpha-1D adrenergic receptor
    Protein Accession:
    P25100
    Secondary Accessions:
    • Q9NPY0

    Protein attributes for ADRA1D Gene

    Size:
    572 amino acids
    Molecular mass:
    60463 Da
    Quaternary structure:
    • Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.

neXtProt entry for ADRA1D Gene

Proteomics data for ADRA1D Gene at MOPED

Post-translational modifications for ADRA1D Gene

  • Glycosylation at Asn 65 and Asn 82
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA1D Gene

Domains & Families for ADRA1D Gene

Gene Families for ADRA1D Gene

Suggested Antigen Peptide Sequences for ADRA1D Gene

Graphical View of Domain Structure for InterPro Entry

P25100

UniProtKB/Swiss-Prot:

ADA1D_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
genes like me logo Genes that share domains with ADRA1D: view

Function for ADRA1D Gene

Molecular function for ADRA1D Gene

GENATLAS Biochemistry:
adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphadidylinositol/Ca2+ second messenger system
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Gene Ontology (GO) - Molecular Function for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004937 alpha1-adrenergic receptor activity IEA --
genes like me logo Genes that share ontologies with ADRA1D: view
genes like me logo Genes that share phenotypes with ADRA1D: view

Animal Models for ADRA1D Gene

MGI Knock Outs for ADRA1D:

Animal Model Products

miRNA for ADRA1D Gene

miRTarBase miRNAs that target ADRA1D

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1D Gene

Localization for ADRA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA1D Gene COMPARTMENTS Subcellular localization image for ADRA1D gene
Compartment Confidence
plasma membrane 5
cytosol 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with ADRA1D: view

Pathways & Interactions for ADRA1D Gene

genes like me logo Genes that share pathways with ADRA1D: view

Gene Ontology (GO) - Biological Process for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 1656955
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 10820200
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA --
GO:0007267 cell-cell signaling TAS 1656955
genes like me logo Genes that share ontologies with ADRA1D: view

No data available for SIGNOR curated interactions for ADRA1D Gene

Drugs & Compounds for ADRA1D Gene

(136) Drugs for ADRA1D Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamsulosin Approved, Investigational Pharma Antagonist, antagonist, Target 152
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 22
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 59
Norepinephrine Approved Pharma stimulator, Target, agonist 654
Droxidopa Approved, Investigational Pharma Target, agonist 27

(9) Additional Compounds for ADRA1D Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
alpha-methylnoradrenaline
Full agonist, Agonist
Promazine 5-sulfoxide
(R)-(-)-Phenylephrine hydrochloride
61-76-7
A 61603 hydrobromide
107756-30-9

(5) Tocris Compounds for ADRA1D Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist 61-76-7
A 61603 hydrobromide alpha1A agonist 107756-30-9
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
HEAT hydrochloride Highly selective alpha1 antagonist 30007-39-7
Oxymetazoline hydrochloride alpha1A agonist 2315-02-8

(57) ApexBio Compounds for ADRA1D Gene

Compound Action Cas Number
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Carvedilol 72956-09-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
DL-Adrenaline 329-65-7
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Propranolol HCl 318-98-9
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
Silodosin α1-adrenoceptor antagonist 160970-54-7
Synephrine HCl 5985-28-4
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
genes like me logo Genes that share compounds with ADRA1D: view

Transcripts for ADRA1D Gene

mRNA/cDNA for ADRA1D Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1D Gene

Adrenoceptor alpha 1D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1D Gene

No ASD Table

Relevant External Links for ADRA1D Gene

GeneLoc Exon Structure for
ADRA1D
ECgene alternative splicing isoforms for
ADRA1D

Expression for ADRA1D Gene

mRNA expression in normal human tissues for ADRA1D Gene

mRNA differential expression in normal tissues according to GTEx for ADRA1D Gene

This gene is overexpressed in Artery - Aorta (x5.5), Brain - Hippocampus (x4.4), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for ADRA1D Gene

This gene is overexpressed in Cervix (55.6) and Kidney (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRA1D Gene



SOURCE GeneReport for Unigene cluster for ADRA1D Gene Hs.557

genes like me logo Genes that share expression patterns with ADRA1D: view

Protein tissue co-expression partners for ADRA1D Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADRA1D Gene

Orthologs for ADRA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRA1D 35
  • 82.33 (n)
  • 81.14 (a)
ADRA1D 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra1d 35
  • 82.27 (n)
  • 84.34 (a)
Adra1d 16
Adra1d 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRA1D 35
  • 97.85 (n)
  • 97.14 (a)
rat
(Rattus norvegicus)
Mammalia Adra1d 35
  • 81.94 (n)
  • 84.31 (a)
dog
(Canis familiaris)
Mammalia ADRA1D 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA1D 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA1D 35
  • 68.35 (n)
  • 63.56 (a)
ADRA1D 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA1D 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495969 35
  • 66.05 (n)
  • 63.58 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568614 35
  • 61.77 (n)
  • 61.56 (a)
adra1d 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 34 (a)
5-HT1B 37
  • 38 (a)
CG6919 37
  • 34 (a)
CG6989 37
  • 33 (a)
CG7431 37
  • 44 (a)
DopR 37
  • 36 (a)
DopR2 37
  • 45 (a)
Oamb 37
  • 53 (a)
Oamb 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-4 36
  • 25 (a)
OneToMany
Species with no ortholog for ADRA1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1D Gene

ENSEMBL:
Gene Tree for ADRA1D (if available)
TreeFam:
Gene Tree for ADRA1D (if available)

Paralogs for ADRA1D Gene

(16) SIMAP similar genes for ADRA1D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADRA1D: view

Variants for ADRA1D Gene

Sequence variations from dbSNP and Humsavar for ADRA1D Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs709023 -- 4,220,483(+) GACAA(A/T)TTGTG downstream-variant-500B
rs709024 -- 4,221,337(+) CCCCA(C/T)TACTT utr-variant-3-prime
rs709025 -- 4,224,704(+) CAAGC(A/G)GGCCA intron-variant
rs709026 -- 4,229,396(+) tacta(A/G)ggaga intron-variant
rs1055522 -- 4,220,949(-) GTCCG(C/T)CACCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADRA1D Gene

Variant ID Type Subtype PubMed ID
esv2722127 CNV Deletion 23290073
esv2722129 CNV Deletion 23290073
nsv178938 CNV Loss 16902084
esv2722130 CNV Deletion 23290073
nsv180352 CNV Loss 16902084
nsv833901 CNV Gain 17160897
esv2661469 CNV Deletion 23128226

Variation tolerance for ADRA1D Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA1D Gene

HapMap Linkage Disequilibrium report
ADRA1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1D Gene

Disorders for ADRA1D Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADRA1D Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • hypertension, essential 3
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA1D

Genetic Association Database (GAD)
ADRA1D
Human Genome Epidemiology (HuGE) Navigator
ADRA1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA1D
genes like me logo Genes that share disorders with ADRA1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1D Gene

Publications for ADRA1D Gene

  1. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PMID: 18187928) Nagaoka Y. … Nagatomo T. (J. Pharmacol. Sci. 2008) 3 23 25 26
  2. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PMID: 12442007) Sugaya K. … Ogawa Y. (J. Urol. 2002) 3 23 48 67
  3. Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms. (PMID: 15639685) Lowe F.C. (Clin Ther 2004) 23 25 26
  4. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. (PMID: 20030735) Haenisch B. … BAPnisch H. (Fundam Clin Pharmacol 2010) 25 26
  5. The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. (PMID: 20363235) Nojimoto F.D. … Pupo A.S. (Neuropharmacology 2010) 25 26

Products for ADRA1D Gene

Sources for ADRA1D Gene

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