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Aliases for ADRA1B Gene

Aliases for ADRA1B Gene

  • Adrenoceptor Alpha 1B 2 3
  • Adrenergic, Alpha-1B-, Receptor 2 3
  • Alpha-1B Adrenoreceptor 3 4
  • Alpha-1B Adrenoceptor 3 4
  • Alpha-1B Adrenergic Receptor 3
  • Alpha-1B-Adrenergic Receptor 3
  • ADRA1 3

External Ids for ADRA1B Gene

Previous GeneCards Identifiers for ADRA1B Gene

  • GC05P159198
  • GC05P159324
  • GC05P159276
  • GC05P154438
  • GC05P159343

Summaries for ADRA1B Gene

Entrez Gene Summary for ADRA1B Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1B Gene

ADRA1B (Adrenoceptor Alpha 1B) is a Protein Coding gene. Diseases associated with ADRA1B include ureterolithiasis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein heterodimerization activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1B Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1B Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1B Gene

Genomics for ADRA1B Gene

Regulatory Elements for ADRA1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADRA1B Gene

159,916,733 bp from pter
159,985,786 bp from pter
69,054 bases
Plus strand

Genomic View for ADRA1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1B Gene

Proteins for ADRA1B Gene

  • Protein details for ADRA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1B adrenergic receptor
    Protein Accession:
    Secondary Accessions:
    • B0LPE1

    Protein attributes for ADRA1B Gene

    520 amino acids
    Molecular mass:
    56836 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

neXtProt entry for ADRA1B Gene

Proteomics data for ADRA1B Gene at MOPED

Post-translational modifications for ADRA1B Gene

  • Glycosylation at Asn10, Asn24, Asn29, and Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ADRA1B (alpha-1B Adrenergic R/ADRA1B)

No data available for DME Specific Peptides for ADRA1B Gene

Domains for ADRA1B Gene

Gene Families for ADRA1B Gene

  • ADRA :GPCR / Class A : Adrenoceptors : alpha

Suggested Antigen Peptide Sequences for ADRA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P35368
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
genes like me logo Genes that share domains with ADRA1B: view

Function for ADRA1B Gene

Molecular function for ADRA1B Gene

GENATLAS Biochemistry:
adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Gene Ontology (GO) - Molecular Function for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004937 alpha1-adrenergic receptor activity IEA --
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1B: view
genes like me logo Genes that share phenotypes with ADRA1B: view

Animal Models for ADRA1B Gene

MGI Knock Outs for ADRA1B:

miRNA for ADRA1B Gene

miRTarBase miRNAs that target ADRA1B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADRA1B Gene

Localization for ADRA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1B Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

Jensen Localization Image for ADRA1B Gene COMPARTMENTS Subcellular localization image for ADRA1B gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22120526
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1328250
GO:0016021 integral component of membrane --
GO:0031965 nuclear membrane IDA 22120526
genes like me logo Genes that share ontologies with ADRA1B: view

Pathways for ADRA1B Gene

genes like me logo Genes that share pathways with ADRA1B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0001975 response to amphetamine IEA --
GO:0001987 vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure IEA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
genes like me logo Genes that share ontologies with ADRA1B: view

Compounds for ADRA1B Gene

(5) Tocris Compounds for ADRA1B Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist [61-76-7]
A 61603 hydrobromide alpha1A agonist [107756-30-9]
Cirazoline hydrochloride Selective alpha1 agonist [40600-13-3]
Naftopidil hydrochloride alpha1 antagonist [1164469-60-6]
RS 17053 hydrochloride alpha1A antagonist [169505-93-5]

(53) ApexBio Compounds for ADRA1B Gene

Compound Action Cas Number
Acebutolol HCl [34381-68-5]
Adrenalone HCl [62-13-5]
Alfuzosin HCl "α1 adrenoceptor antagonist,functionally uro-selective" [81403-68-1]
Bambuterol [81732-65-2]
Betaxolol βadrenergic receptor blocker [659-18-7]
Betaxolol HCl [63659-19-8]
Bisoprolol fumarate [104344-23-2]
Carvedilol [72956-09-3]
Cisatracurium Besylate Neuromuscular-blocking drug [96946-42-8]
Clonidine HCl [4205-91-8]
Detomidine HCl [90038-01-0]
Dexmedetomidine [113775-47-6]
Dexmedetomidine HCl [145108-58-3]
DL-Adrenaline [329-65-7]
Doxazosin Mesylate α1-adrenergic receptor antagonist [77883-43-3]
Epinephrine Bitartrate [51-42-3]
Epinephrine HCl [55-31-2]
Formoterol Hemifumarate [43229-80-7]
Guanabenz Acetate [23256-50-0]
Indacaterol Maleate [753498-25-8]
Isoprenaline HCl [51-30-9]
Ivabradine HCl [148849-67-6]
Labetalol HCl [32780-64-6]
L-Adrenaline [51-43-4]
Maprotiline HCl [10347-81-6]
Medetomidine HCl [86347-15-1]
Methyldopa [555-30-6]
Metoprolol Tartrate β1-adrenergic blocking agent [392-17-7]
Mirabegron (YM178) [223673-61-8]
Naftopidil α1-adrenergic receptor antagonist [57149-07-2]
Naftopidil DiHCl [57149-08-3]
Naphazoline HCl [550-99-2]
Nebivolol [152520-56-4]
Nedaplatin [95734-82-0]
Oxymetazoline HCl Alpha-1/alpha-2 agonist [2315-2-8]
Phenoxybenzamine HCl [63-92-3]
Phentolamine Mesylate Alpha 1/2-blocking agent [65-28-1]
Phenylephrine HCl [61-76-7]
Prazosin HCl α1 and α2B-adrenoceptor antagonist [19237-84-4]
Propranolol HCl [318-98-9]
Ritodrine HCl β-2 adrenergic receptor agonist [23239-51-2]
Salbutamol Sulfate β-2 adrenergic receptor agonist [51022-70-9]
Salmeterol xinafoate β2-adrenergic receptor agonist [94749-08-3]
Scopine [498-45-3]
Silodosin α1-adrenoceptor antagonist [160970-54-7]
Synephrine HCl [5985-28-4]
Terazosin HCl [70024-40-7]
Terbutaline Sulfate [23031-32-5]
Tetrahydrozoline HCl [522-48-5]
Timolol Maleate [26921-17-5]
Tizanidine HCl [64461-82-1]
Tolazoline HCl [59-97-2]
Xylazine HCl α2 Adrenoceptor agonist [23076-35-9]

(6) HMDB Compounds for ADRA1B Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • (-)-(R)-Norepinephrine
  • Lanzac
  • Adrianol
  • Quetiapine fumarate

(43) Drugbank Compounds for ADRA1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7 target antagonist
81403-80-7 target antagonist
  • OPC 31
129722-12-9 target antagonist
  • Bromergocryptine
25614-03-3 target agonist
50-53-3 target antagonist

(34) IUPHAR Ligand for ADRA1B Gene

Ligand Type Action Affinity Pubmed IDs
tamsulosin Antagonist Antagonist 10.7
silodosin Antagonist Antagonist 10.4
cyproheptadine Antagonist Antagonist 10.2
[125I]HEAT Agonist Full agonist 10
(+)-niguldipine Antagonist Antagonist 10
prazosin Antagonist Inverse agonist 9.9
[125I]BE-2254 Antagonist Antagonist 9.9
WB 4101 Antagonist Antagonist 9.8
Rec 15/2739 Antagonist Antagonist 9.6
NAN 190 Antagonist Antagonist 9.4
5-methylurapidil Antagonist Antagonist 9.2
Ro-70-0004 Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
A-119637 Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
rho-TIA Antagonist Antagonist 8.4
A-123189 Antagonist Antagonist 8.4
indoramin Antagonist Antagonist 8.4
BMY-7378 Agonist Partial agonist 8
(+)-cyclazosin Antagonist Antagonist 7.9
risperidone Antagonist Antagonist 7.8
L-765314 Antagonist Antagonist 7.7
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
oxymetazoline Agonist Full agonist 6.8
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
ketanserin Inhibitor Inhibition 6.3
(-)-adrenaline Agonist Full agonist 6.2
NS-49 Agonist Partial agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
phenylephrine Agonist Full agonist 5.4
methoxamine Agonist Full agonist 5.2
(+)-adrenaline Agonist Full agonist 5

(21) Novoseek inferred chemical compound relationships for ADRA1B Gene

Compound -log(P) Hits PubMed IDs
chloroethylclonidine 74.6 1
norepinephrine 53.1 10
prazosin 52.1 1
phosphoinositide 41.4 1
phenylephrine 39 2
genes like me logo Genes that share compounds with ADRA1B: view

Transcripts for ADRA1B Gene

mRNA/cDNA for ADRA1B Gene

(10) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1B Gene

Adrenoceptor alpha 1B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADRA1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1B Gene

No ASD Table

Relevant External Links for ADRA1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADRA1B Gene

mRNA expression in normal human tissues for ADRA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1B Gene

This gene is overexpressed in Artery - Aorta (7.3) and Liver (4.1).

Protein differential expression in normal tissues for ADRA1B Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRA1B Gene

SOURCE GeneReport for Unigene cluster for ADRA1B Gene Hs.368632

genes like me logo Genes that share expressions with ADRA1B: view

Expression partners for ADRA1B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRA1B Gene

Orthologs for ADRA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADRA1B 35
  • 93.72 (n)
  • 97.28 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ADRA1B 35
  • 92.94 (n)
  • 94.76 (a)
  • 96 (a)
(Mus musculus)
Mammalia Adra1b 35
  • 90.55 (n)
  • 96.31 (a)
Adra1b 16
Adra1b 36
  • 96 (a)
(Pan troglodytes)
Mammalia ADRA1B 35
  • 98.52 (n)
  • 98.45 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Adra1b 35
  • 90.74 (n)
  • 95.73 (a)
(Monodelphis domestica)
Mammalia ADRA1B 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ADRA1B 36
  • 79 (a)
(Gallus gallus)
Aves ADRA1B 35
  • 68.89 (n)
  • 75.99 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488806 35
  • 64.91 (n)
  • 65.07 (a)
(Danio rerio)
Actinopterygii adra1bb 35
  • 68.06 (n)
  • 70.23 (a)
ADRA1B (1 of 2) 36
  • 61 (a)
adra1bb 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 35 (a)
5-HT1B 37
  • 39 (a)
5-HT7 37
  • 32 (a)
CG6919 37
  • 37 (a)
CG6989 37
  • 35 (a)
CG7431 37
  • 44 (a)
DopR 37
  • 36 (a)
DopR2 37
  • 43 (a)
Oamb 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea C52B11.3 37
  • 34 (a)
dop-4 36
  • 27 (a)
Species with no ortholog for ADRA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1B Gene

Gene Tree for ADRA1B (if available)
Gene Tree for ADRA1B (if available)

Paralogs for ADRA1B Gene

Paralogs for ADRA1B Gene

Selected SIMAP similar genes for ADRA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRA1B: view

Variants for ADRA1B Gene

Sequence variations from dbSNP and Humsavar for ADRA1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs756275 -- 159,924,453(-) CTCCC(A/G)TTTTC intron-variant
rs876528 -- 159,964,639(-) GCTGT(C/T)GTCAT intron-variant
rs876529 -- 159,964,625(-) CTCAA(A/G)GGGAT intron-variant
rs925995 -- 159,925,301(+) AATTG(C/G)GTCGT intron-variant
rs952037 -- 159,963,870(+) TTTGA(C/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1B Gene

Variant ID Type Subtype PubMed ID
nsv462500 CNV Loss 19166990
nsv830531 CNV Loss 17160897
esv22831 CNV Loss 19812545

Relevant External Links for ADRA1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1B Gene

Disorders for ADRA1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADRA1B Gene in MalaCards »

(1) Diseases for ADRA1B Gene including...

(2) University of Copenhagen DISEASES for ADRA1B Gene

(3) Novoseek inferred disease relationships for ADRA1B Gene

Disease -log(P) Hits PubMed IDs
hyperfunction 40.6 2
cardiomyopathy 0 1
heart failure 0 1

Relevant External Links for ADRA1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADRA1B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADRA1B Gene

Publications for ADRA1B Gene

  1. Genomic organization and expression of the human alpha 1B-adrenergic receptor. (PMID: 1328250) Ramarao C.S. … Graham R.M. (J. Biol. Chem. 1992) 3 4 23
  2. A genome-wide association study on African-ancestry populations for asthma. (PMID: 19910028) Mathias R.A. … Barnes K.C. (J. Allergy Clin. Immunol. 2010) 3 23 48
  3. Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. (PMID: 18523139) Stanasila L. … Cotecchia S. (Mol. Pharmacol. 2008) 3 23
  4. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (PMID: 7815325) Schwinn D.A. … Bailey D.S. (J. Pharmacol. Exp. Ther. 1995) 3 4
  5. Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. (PMID: 16352594) Stanasila L. … Cotecchia S. (J. Biol. Chem. 2006) 3 23

Products for ADRA1B Gene

Sources for ADRA1B Gene

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