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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADRA1B Gene

protein-coding GIFtS: 69
GCID: GC05P159276

adrenoceptor alpha 1B

(Previous names: adrenergic, alpha-1B-, receptor )

Explore 29 diseases affiliated with
ADRA1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenoceptor Alpha 1B¹ ²		ADRA1²
Adrenergic, Alpha-1B-, Receptor¹ ²		ALPHA1BAR²
Alpha-1B Adrenoceptor² ³		Alpha-1B Adrenergic Receptor²
Alpha-1B Adrenoreceptor² ³		Alpha-1B-Adrenergic Receptor²

External Ids:	HGNC: 278¹	Entrez Gene: 147²	Ensembl: ENSG00000170214⁷	OMIM: 104220⁵	UniProtKB: P35368³

Export aliases for ADRA1B gene to outside databases

Previous GC identifers: GC05P159198 GC05P159853 GC05P159324 GC05P154438

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADRA1B:

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate

mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A,

-1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns

of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when

transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a

protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding

region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear

ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes

summary for ADRA1B:

Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of

G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The

adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in

smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L

based on its low affinity for prazosin. It has been suggested that this subtype may represent a different

conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1B (Alpha-1B adrenergic receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADRA1B gene promoter:
HOXA9 AhR Arnt E47 HFH-1 STAT3 Hand1 ARP-1 ZID
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ADRA1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3

ADRA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA1B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P159276: view genomic region (about GC identifiers)

Start:	159,343,740 bp from pter	End:	159,400,017 bp from pter
Size:	56,278 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368 (See protein sequence)

Recommended Name: Alpha-1B adrenergic receptor

Size: 520 amino acids; 56836 Da

Subunit: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes

Subcellular location: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in

cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane

of cardiac myocytes

Secondary accessions: B0LPE1

Explore the universe of human proteins at neXtProt for ADRA1B: NX_P35368

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35368

ADRA1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000670.1

ENSEMBL proteins:

ENSP00000306662

Reactome Protein details: P35368
Human Recombinant Protein Products for ADRA1B:

	EMD Millipore Purified and/or Recombinant ADRA1B Protein
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	Novus Biologicals ADRA1B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000299	integral to membrane of membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1328250
GO:0031965	nuclear membrane	IDA	--

ADRA1B for ontologies About GeneDecksing

ADRA1B Antibody Products:

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Assay Products for ADRA1B:

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	GenScript ADRA1B-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADRA1B for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002233 Adrnrgc_rcpt

IPR001115 Adrene_rcpt_A1B

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P35368

ProtoNet protein and cluster: P35368

2 Blocks protein families:

IPB001115 Alpha-1B adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADA1B_HUMAN, P35368

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear

ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes

Genatlas biochemistry entry for ADRA1B:

adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the

phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004937	alpha1-adrenergic receptor activity	IEA	--
GO:0046982	protein heterodimerization activity	IDA	--

ADRA1B for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ADRA1B:

Decreased Hepatitis C virus re

Decreased substrate adherent c

12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra1b):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	homeostasis/metabolism	mortality/aging	muscle	nervous system
renal/urinary system	reproductive system

ADRA1B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adra1b^tm1Cta for ADRA1B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADRA1B

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRA1B
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRA1B (see all 15):
		hsa-miR-3173-3p hsa-miR-22 hsa-miR-519d hsa-miR-20a hsa-miR-539 hsa-miR-106a hsa-miR-324-3p hsa-miR-106b

		SwitchGear 3'UTR luciferase reporter plasmid: ADRA1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRA1B (see all 7) OriGene shRNA RFP: ADRA1B OriGene siRNA: ADRA1B
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ADRA1B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADRA1B
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Clone Products:		EMD Millipore Clones for the Expression of ADRA1B
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADRA1B (NM_000679)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1B

Cell Line Products:		GenScript ADRA1B-overexpressing Cell Line for Assay
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translation_Translation regulation by Alpha-1 adrenergic receptors

	Translation_Translation regulation by Alpha-1 adrenergic receptors	1.00			Development_Activation of ERK by Alpha-1 adrenergic receptors	0.64
	Translation Translation regulation by Alpha-1 adrenergic receptors	1.00			Development Activation of ERK by Alpha-1 adrenergic receptors	0.64

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ADRA1B

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA1B

	Activation of PKA through GPCR
	AMPK Enzyme Complex Pathway
	cAMP Pathway
	Activation of cAMP-Dependent PKA
	Signaling Involved in Cardiac Hypertrophy

2 GeneGo (Thomson Reuters) Pathways for ADRA1B

	Development Activation of ERK by Alpha-1 adrenergic receptors
	Translation Translation regulation by Alpha-1 adrenergic receptors

5 BioSystems Pathways for ADRA1B

	Calcium Regulation in the Cardiac Cell
	AMPK signaling
	GPCRs, Class A Rhodopsin-like
	LPA receptor mediated events
	Monoamine GPCRs

5/10 Reactome Pathways for ADRA1B (see all 10)

	GPCR downstream signaling
	G alpha (12/13) signalling events
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

1 PharmGKB Pathway for ADRA1B

Sympathetic Nerve Pathway (Neuroeffector Junction)

4 Kegg Pathways (Kegg details for ADRA1B):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Salivary secretion

ADRA1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADRA1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/140 Interacting proteins for ADRA1B (P35368^{2, 3} ENSP00000306662⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 140)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1R9B	Q96SB3²^,³	MINT-4953469 I2D: score=2
ADRA1A	P35348³, ENSP00000369960⁴	I2D: score=1 STRING: ENSP00000369960
EZR	P15311³, ENSP00000338934⁴	I2D: score=1 STRING: ENSP00000338934
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=1 STRING: ENSP00000286548
NOS1	P29475³, ENSP00000320758⁴	I2D: score=1 STRING: ENSP00000320758

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001974	blood vessel remodeling	IEA	--
GO:0001975	response to amphetamine	IEA	--
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	IEA	--
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IEA	--
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA	--

ADRA1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADRA1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADRA1B available from Tocris Bioscience About this table

Compound	Action	CAS #
AH 11110 hydrochloride	Subtype-selective alpha1B ligand	[179388-65-9]
Cirazoline hydrochloride	Selective alpha1 agonist	[40600-13-3]
Rec 15/2615 dihydrochloride	Selective alpha1B antagonist	[173059-17-1]
Prazosin hydrochloride	alpha1 and alpha2B antagonist. MT3 antagonist	[19237-84-4]
HEAT hydrochloride	Highly selective alpha1 antagonist	[30007-39-7]

6 HMDB Compounds for ADRA1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Norepinephrine	(-)-(R)-Norepinephrine (see all 32)	51-41-2	--
Olanzapine	Lanzac (see all 5)	132539-06-1	--
Phenylephrine	Adrianol (see all 60)	59-42-7	--
Quetiapine	Quetiapine fumarate (see all 2)	111974-69-7	--
Risperidone	Belivon (see all 7)	106266-06-2	--

10/41 DrugBank Compounds for ADRA1B (see all 41) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alfuzosin	--	81403-80-7	target	antagonist	9122046 15639685 11750253 9870119 11752352 16553574 8196478 16613526 8799556
Paliperidone	--	144598-75-4	target	antagonist	8925876 18542932 15992090 15907153 7531353 7524043 7691623 11132243
Labetalol	Labetalol HCL (see all 4)	36894-69-6	target	antagonist	1358746 17686376 6355664 10529655 2696507 7684671 8104240
Norepinephrine	Arterenol (see all 4)	51-41-2	target	agonist	17266602 18064417 8166240 17139284 7773533 8294418 17016423
Prazosin	Prazocin (see all 6)	19216-56-9	target	antagonist	7855217 8925876 11752352 12824165 11156594 7691623 12270758
Phendimetrazine	(+)-3,4-Dimethyl-2-phenylmorpholine (see all 6)	634-03-7	target	agonist	11054601 17139284 11752352 17016423 16265126 17017961
Risperidone	risperdone (see all 3)	106266-06-2	target	antagonist	8925876 15992090 11752352 15907153 7691623 11132243
Tamsulosin	--	106133-20-4	target	antagonist	9294627 11752352 14680444 8996174 12270758 7911719
Methoxamine	--	390-28-3	target	agonist	8635240 2988814 11752352 11331292 2546049
Doxazosin	Doxazosin mesilate (see all 2)	74191-85-8	target	antagonist	18231614 19002123 10393471 17070143

10/21 Novoseek chemical compound relationships for ADRA1B gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chloroethylclonidine	74.6	2	2163016 (1)
norepinephrine	53.1	10	11441921 (6), 1337829 (1), 8190093 (1), 16195468 (1) (see all 5)
prazosin	52.1	1	17917257 (1)
phosphoinositide	41.4	1	12880866 (1)
phenylephrine	39	5	9771908 (1), 10912793 (1)
methoxamine	38.4	1	9048657 (1)
epinephrine	34.1	3	9353340 (2), 8910453 (1)
phorbol	27.9	3	9353340 (3)
bapta	26.4	1	11441921 (1)
catecholamine	23.2	3	10347189 (2), 8980109 (1)

Search CenterWatch for drugs/clinical trials and news about ADRA1B / ADA1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADRA1B gene:

NM_000679.3

Unigene Cluster for ADRA1B:

Adrenoceptor alpha 1B

Hs.368632 [show with all ESTs]

Unigene Representative Sequence: NM_000679

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000306675(uc003lxt.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADRA1B
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ADRA1B (see all 15):
		hsa-miR-3173-3p hsa-miR-22 hsa-miR-519d hsa-miR-20a hsa-miR-539 hsa-miR-106a hsa-miR-324-3p hsa-miR-106b

		SwitchGear 3'UTR luciferase reporter plasmid: ADRA1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADRA1B (see all 7) OriGene shRNA RFP: ADRA1B OriGene siRNA: ADRA1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADRA1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADRA1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADRA1B (NM_000679)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRA1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADRA1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADRA1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADRA1B

Additional cDNA sequence:

AK309989.1 BC136568.1 BC136569.1 L31773.1 U03865.1

1 DOTS entry:

DT.304573

11 AceView cDNA sequences:

AI566163 CB044689 U03865 AW138726 BQ576306 NM_000679 CB044690 L31773

AW732369 AW733134 AW236065

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADRA1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGAGCCT

About this image

ADRA1B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Primitive gut tube-like cells (A scalable, suspensi...)

See ADRA1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRA1B

SOURCE GeneReport for Unigene cluster: Hs.368632

SABiosciences Expression via Pathway-Focused PCR Arrays including ADRA1B:

G Protein Coupled Receptors 384HT in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADRA1B gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	ADRA1B¹	adrenergic, alpha-1B-, receptor	68.82(n) 75.99(a)	373890 XM_414483.2 XP_414483.2
zebrafish (Danio rerio)	Actinopterygii	adra1bb¹	adrenergic receptor, alpha 1bb	68.23(n) 70.76(a)	492486 NM_001007358.1 NP_001007359.1
worm (Caenorhabditis elegans)	Secernentea	C52B11.3³	G-protein coupled receptor	34(a)	X(1330197-1335711) --

ENSEMBL Gene Tree for ADRA1B (if available)
TreeFam Gene Tree for ADRA1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ADRA1B gene

DRD4² HTR1A² DRD2² HTR1F² HTR7² ADRA2C² ADRA2A² HTR1D²

ADRA1A² ADRA2B² HTR1E² DRD3² HTR5A² HTR1B² ADRA1D²

18/19 SIMAP similar genes for ADRA1B using alignment to 1 protein entry: ADA1B_HUMAN(see all similar genes):

ADRA1A ADRA1D HTR7 HTR1B HTR5A ADRB3

DRD1 ADRB1 HTR1F HRH2 HTR1D HTR2A

HTR2C HTR1E 5HT1A DRD3 HTR1A TAAR1

ADRA1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147594526^1,2		--	159341854(+)	`AGGCTC/TGTGAA`	1	--	us2k¹		0	--	--	--	--
rs77875476^1,2	F	--	159342026(+)	`GAATTG/ATAAAG`	1	--	us2k¹		1		NA	120
rs11742180^1,2	H	--	159342065(+)	`TATCAC/GTAAGC`	1	--	us2k¹		0	--	--	--	--
rs187331714^1,2		--	159342071(+)	`TAAGCA/GCTCAA`	1	--	us2k¹		0	--	--	--	--
rs78123327^1,2	C,F	--	159342095(+)	`CTGCCC/TAGCAC`	1	--	us2k¹		1		WA	118
rs75958981^1,2	F	--	159342283(+)	`TGGGCG/AAACAG`	1	--	us2k¹		1		WA	118
rs78007572^1,2	F	--	159342345(+)	`AGTGTA/GTTCTT`	1	--	us2k¹		1		NA	120
rs142028141^1,2		--	159342415(+)	`TAAATA/GTTGGA`	1	--	us2k¹		0	--	--	--	--
rs145779587^1,2		--	159342473(+)	`CTTGGA/CCCATA`	1	--	us2k¹		0	--	--	--	--
rs77465174^1,2	F	--	159342474(+)	`TTGGCC/TCATAC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for ADRA1B (159343740 - 159400017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADRA1B
1 CNV: 64350

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ADRA1B for disorders           About GeneDecksing

OMIM gene information: 104220    OMIM disorders: --

20/29 diseases for ADRA1B (see all 29):    About MalaCards

situs inversus autism spectrum disorder sleep apnea ureter carcinoma

ureterolithiasis anorexia nervosa apnea gastroparesis

mood disorder essential hypertension urethritis hypothyroidism

rabies pertussis hypertension seizures

gastric cancer pharyngitis prostate cancer breast cancer

1 disease from the University of Copenhagen DISEASES database for ADRA1B:

Ureterolithiasis

3 Novoseek disease relationships for ADRA1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperfunction	40.6	2	9004925 (1), 9754358 (1)
cardiomyopathy	0	1	15674439 (1)
heart failure	0	1	15674439 (1)

Genetic Association Database (GAD): ADRA1B
Human Genome Epidemiology (HuGE) Navigator: ADRA1B (15 documents)

Export disorders for ADRA1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADRA1B gene, integrated from 9 sources (see all 230):
(articles sorted by number of sources associating them with ADRA1B)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization and expression of the human alpha 1B-adrenergic receptor. (PubMed id 1328250)^{1, 2, 9} Ramarao C.S....Graham R.M. (1992)
Functional alpha-1B adrenergic receptors on human epi cardial coronary artery endothelial cells. (PubMed id 20857090)^{1, 7} Jensen B.C....Simpson P.C. (2010)
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)^{1, 4} Matayoshi T....Kawano Y. (2004)
Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. (PubMed id 12023679)^{1, 4} McCaffery J.M....Manuck S.B. (2002)
Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (PubMed id 7815325)^{1, 2} Schwinn D.A.... Bailey D.S. (1995)
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)^{1, 2} Forray C.... Gluchowski C. (1994)
Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. (PubMed id 8617782)^{1, 9} Diviani D....Cotecchia S. (1996)
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. (PubMed id 18523139)^{1, 9} Stanasila L....Cotecchia S. (2008)
Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. (PubMed id 9353340)^{1, 9} Diviani D....Cotecchia S. (1997)
Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. (PubMed id 16352594)^{1, 9} Stanasila L....Cotecchia S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147	HGNC: 278	AceView: ADRA1B	Ensembl:ENSG00000170214	euGenes: HUgn147
ECgene: ADRA1B	Kegg: 147	H-InvDB: ADRA1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADRA1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADRA1B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADRA1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADRA1B gene:
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GeneCards and IP:
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ADRA1B Gene

adrenoceptor alpha 1B

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ADRA1B Gene

adrenoceptor alpha 1B

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