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ADRA1B Gene

protein-coding   GIFtS: 72
GCID: GC05P159343

Adrenoceptor Alpha 1B

(Previous names: adrenergic, alpha-1B-, receptor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 1B1 2     ADRA12
Adrenergic, Alpha-1B-, Receptor1 2     ALPHA1BAR2
Alpha-1B Adrenoceptor2 3     Alpha-1B Adrenergic Receptor2
Alpha-1B Adrenoreceptor2 3     Alpha-1B-Adrenergic Receptor2

External Ids:    HGNC: 2781   Entrez Gene: 1472   Ensembl: ENSG000001702147   OMIM: 1042205   UniProtKB: P353683   

Export aliases for ADRA1B gene to outside databases

Previous GC identifers: GC05P159198 GC05P159853 GC05P159324 GC05P159276 GC05P154438


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA1B Gene:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They
activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR
subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different
subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces
neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal
cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least
20 kb that interrupts the coding region. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA1B Gene:
ADRA1B (adrenoceptor alpha 1B) is a protein-coding gene. Diseases associated with ADRA1B include ureterolithiasis, and gastroparesis. GO annotations related to this gene include protein heterodimerization activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear
ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes

summary for ADRA1B Gene:
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The
adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.
lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in
smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L
based on its low affinity for prazosin. It has been suggested that this subtype may represent a different
conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1B (Alpha-1B adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA1B gene promoter:
         HOXA9   AhR   Arnt   E47   HFH-1   STAT3   Hand1   ARP-1   ZID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ADRA1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

ADRA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159343:  view genomic region     (about GC identifiers)

Start:
159,343,740 bp from pter      End:
159,400,017 bp from pter
Size:
56,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368 (See protein sequence)
Recommended Name: Alpha-1B adrenergic receptor  
Size: 520 amino acids; 56836 Da
Subunit: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes
Secondary accessions: B0LPE1

Explore the universe of human proteins at neXtProt for ADRA1B: NX_P35368

Explore proteomics data for ADRA1B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn24, Asn29, Asn34
  • Modification sites at PhosphoSitePlus

  • See ADRA1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000670.1  
    ENSEMBL proteins: 
     ENSP00000306662  
    Reactome Protein details: P35368

    ADRA1B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ADRA1B Protein
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    OriGene Protein Over-expression Lysate for ADRA1B
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    Novus Biologicals ADRA1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ADRA1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ADRA1B Antibodies
    Abcam antibodies for ADRA1B (P25100, P35368, P35348)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ADRA1B
    LSBio Antibodies in human, mouse, rat for ADRA1B

    ADRA1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript ADRA1B-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha1B-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001115 ADRA1B_rcpt
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P35368

    ProtoNet protein and cluster: P35368

    2 Blocks protein domains:
    IPB001115 Alpha-1B adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA1B_HUMAN, P35368
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B
    sub-subfamily


    ADRA1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA1B_HUMAN, P35368
    Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
    phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear
    ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes

         Genatlas biochemistry entry for ADRA1B:
    adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the
    phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004937alpha1-adrenergic receptor activity IEA--
    GO:0046982protein heterodimerization activity IDA--
         
    ADRA1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADRA1B:
     Decreased Hepatitis C virus re  Decreased substrate adherent c 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adra1b):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     renal/urinary system  reproductive system 

    ADRA1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adra1btm1Cta for ADRA1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRA1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADRA1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADRA1B

    miRNA
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    miRTarBase miRNAs that target ADRA1B:
    hsa-mir-10b-5p (MIRT047408)

    Block miRNA regulation of human, mouse, rat ADRA1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRA1B (see all 15):
    hsa-miR-3173-3p hsa-miR-22 hsa-miR-519d hsa-miR-20a hsa-miR-539 hsa-miR-106a hsa-miR-324-3p hsa-miR-106b
    SwitchGear 3'UTR luciferase reporter plasmidADRA1B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ADRA1B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADRA1B (NM_000679)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADRA1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1B

    Cell Line
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    GenScript ADRA1B-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADRA1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA1B_HUMAN, P35368: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in
    cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear
    membrane of cardiac myocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1328250
    GO:0016021integral component of membrane ----
    GO:0031965nuclear membrane IDA--

    ADRA1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA1B About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA1B
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy

    2 GeneGo (Thomson Reuters) Pathways for ADRA1B
        Development Activation of ERK by Alpha-1 adrenergic receptors
    Translation Translation regulation by Alpha-1 adrenergic receptors

    5 BioSystems Pathways for ADRA1B
        AMPK signaling
    Calcium Regulation in the Cardiac Cell
    GPCRs, Class A Rhodopsin-like
    LPA receptor mediated events
    Monoamine GPCRs

    3 Reactome Pathways for ADRA1B
        G alpha (12/13) signalling events
    G alpha (q) signalling events
    Adrenoceptors

    1 PharmGKB Pathway for ADRA1B
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    5 Kegg Pathways  (Kegg details for ADRA1B):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Salivary secretion


    ADRA1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA1B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRA1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADRA1B (P353682, 3 ENSP000003066624) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R9BQ96SB32, 3MINT-4953469 I2D: score=2 
    ADRA1AP353483, ENSP000003699604I2D: score=1 STRING: ENSP00000369960
    EZRP153113, ENSP000003389344I2D: score=1 STRING: ENSP00000338934
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0001975response to amphetamine IEA--
    GO:0001987vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure IEA--
    GO:0001996positive regulation of heart rate by epinephrine-norepinephrine IEA--
    GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA--

    ADRA1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADRA1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 100329 hydrochloride Potent, subtype-selective alpha1A antagonist [232953-52-5]
    RS 17053 hydrochloridealpha1A antagonist[169505-93-5]
    Cirazoline hydrochlorideSelective alpha1 agonist[40600-13-3]
    (R)-(-)-Phenylephrine hydrochloridealpha1 agonist[61-76-7]
    A 61603 hydrobromidealpha1A agonist[107756-30-9]

    6 HMDB Compounds for ADRA1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    OlanzapineLanzac (see all 5)132539-06-1--
    PhenylephrineAdrianol (see all 60)59-42-7--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    RisperidoneBelivon (see all 7)106266-06-2--

    Selected DrugBank Compounds for ADRA1B (see all 43)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alfuzosin-- 81403-80-7targetantagonist9122046 15639685 11750253 9870119 11752352 16553574 8196478 16613526 8799556
    Paliperidone-- 144598-75-4targetantagonist8925876 18542932 15992090 15907153 7531353 7524043 7691623 11132243
    LabetalolLabetalol HCL (see all 4)36894-69-6targetantagonist1358746 17686376 6355664 10529655 2696507 7684671 8104240
    NorepinephrineArterenol (see all 4)51-41-2targetagonist17266602 18064417 8166240 17139284 7773533 8294418 17016423
    PrazosinPrazocin (see all 6)19216-56-9targetantagonist7855217 8925876 11752352 12824165 11156594 7691623 12270758
    Phendimetrazine(+)-3,4-Dimethyl-2-phenylmorpholine (see all 6)634-03-7targetagonist11054601 17139284 11752352 17016423 16265126 17017961
    Risperidonerisperdone (see all 3)106266-06-2targetantagonist8925876 15992090 11752352 15907153 7691623 11132243
    Tamsulosin-- 106133-20-4targetantagonist9294627 11752352 14680444 8996174 12270758 7911719
    Methoxamine-- 390-28-3targetagonist8635240 2988814 11752352 11331292 2546049
    DoxazosinDoxazosin mesilate (see all 2)74191-85-8targetantagonist18231614 19002123 10393471 17070143

    Selected IUPHAR Ligands for ADRA1B (alpha1B-adrenoceptor) (see all 34)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]HEAT
    AgonistFull agonist10.27651358
    prazosin
    AntagonistInverse agonist9.6 - 9.97651358 9249248 10369480
    [125I]BE-2254
    AntagonistInverse agonist9.97815325 11337028
    (+)-cyclazosin
    AntagonistInverse agonist9.98917649
    tamsulosin
    AntagonistInverse agonist9.6 - 9.79249248 10369480
    spiperone
    AntagonistInverse agonist9.211459121
    NAN 190
    AntagonistAntagonist9.211459121
    WB 4101
    AntagonistAntagonist8.5 - 99249248 7651358
    rho-TIA
    AntagonistAntagonist8.415194691
    A-119637
    AntagonistAntagonist8.311354357

    Selected Novoseek inferred chemical compound relationships for ADRA1B gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloroethylclonidine 74.6 2 2163016 (1)
    norepinephrine 53.1 10 11441921 (6), 1337829 (1), 8190093 (1), 16195468 (1) (see all 5)
    prazosin 52.1 1 17917257 (1)
    phosphoinositide 41.4 1 12880866 (1)
    phenylephrine 39 5 9771908 (1), 10912793 (1)
    methoxamine 38.4 1 9048657 (1)
    epinephrine 34.1 3 9353340 (2), 8910453 (1)
    phorbol 27.9 3 9353340 (3)
    bapta 26.4 1 11441921 (1)
    catecholamine 23.2 3 10347189 (2), 8980109 (1)



    ADRA1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ADRA1B gene: 
    NM_000679.3  

    Unigene Cluster for ADRA1B:

    Adrenoceptor alpha 1B
    Hs.368632  [show with all ESTs]
    Unigene Representative Sequence: NM_000679
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306675(uc003lxt.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ADRA1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADRA1B (see all 15):
    hsa-miR-3173-3p hsa-miR-22 hsa-miR-519d hsa-miR-20a hsa-miR-539 hsa-miR-106a hsa-miR-324-3p hsa-miR-106b
    SwitchGear 3'UTR luciferase reporter plasmidADRA1B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADRA1B
    Predesigned siRNA for gene silencing in human, mouse, rat ADRA1B
    Clone
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    OriGene clones in human, mouse for ADRA1B (see all 5)
    OriGene ORF clones in mouse, rat for ADRA1B
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    GenScript: all cDNA clones in your preferred vector: ADRA1B (NM_000679)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1B
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ADRA1B

    Additional mRNA sequence: 

    AK309989.1 BC136568.1 BC136569.1 L31773.1 U03865.1 

    1 DOTS entry:

    DT.304573 

    11 AceView cDNA sequences:

    AI566163 U03865 AW138726 CB044689 BQ576306 NM_000679 CB044690 L31773 
    AW732369 AW733134 AW236065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGAGCCT
    ADRA1B Expression
    About this image


    ADRA1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    ADRA1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368632
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA1B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra1b1 , 5 adrenergic receptor, alpha 1b1, 5 90.55(n)1
    96.31(a)1
      11 (25.81 cM)5
    115481  NM_001284380.11  NP_001271309.11 
     437746065 
    chicken
    (Gallus gallus)
    Aves ADRA1B1 adrenergic, alpha-1B-, receptor 68.89(n)
    75.99(a)
      373890  XM_414483.3  XP_414483.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    GL343301.1(1464564-1486270)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004888061 alpha-1B adrenergic receptor-like 64.91(n)
    65.07(a)
      100488806  XM_002943068.2  XP_002943114.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adra1bb1 adrenergic receptor, alpha 1bb 68.06(n)
    70.23(a)
      492486  NM_001007358.2  NP_001007359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313 G-protein coupled receptor protein
    signaling pathway more
    44(a)
    (best of 8)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea C52B11.33 G-protein coupled receptor 34(a)   X(1330197-1335711)   --


    ENSEMBL Gene Tree for ADRA1B (if available)
    TreeFam Gene Tree for ADRA1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA1B gene
    HTR1A2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for ADRA1B using alignment to 1 protein entry:     ADA1B_HUMAN(see all similar genes):
    ADRA1A    ADRA1D    HTR7    HTR1B    HTR5A    ADRB3
    DRD1    ADRB1    HTR1F    HRH2    HTR1D    HTR2A
    HTR2C    HTR1E    5HT1A    DRD3    HTR1A    TAAR1

    ADRA1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRA1B (see all 1162)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475945261,2
    --159341854(+) AGGCTC/TGTGAA 1 -- us2k10--------
    rs778754761,2
    F--159342026(+) GAATTG/ATAAAG 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs117421801,2
    H--159342065(+) TATCAC/GTAAGC 1 -- us2k10--------
    rs1873317141,2
    --159342071(+) TAAGCA/GCTCAA 1 -- us2k10--------
    rs781233271,2
    C,F--159342095(+) CTGCCC/TAGCAC 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs759589811,2
    C,F--159342283(+) TGGGCG/AAACAG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs780075721,2
    C,F--159342345(+) AGTGTA/GTTCTT 1 -- us2k11Minor allele frequency- G:0.06NA 120
    rs1420281411,2
    --159342415(+) TAAATA/GTTGGA 1 -- us2k10--------
    rs1457795871,2
    --159342473(+) CTTGGA/CCCATA 1 -- us2k10--------
    rs774651741,2
    C,F--159342474(+) TTGGCC/TCATAC 1 -- us2k11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for ADRA1B (159343740 - 159400017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADRA1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462500CNV Loss19166990
    esv22831CNV Loss19812545
    nsv830531CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRA1B
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRA1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104220    OMIM disorders: --

    Selected diseases for ADRA1B (see all 24):    
    About MalaCards
    ureterolithiasis    gastroparesis    situs inversus    urethritis
    sleep apnea    rabies    mood disorder    autism spectrum disorder
    anorexia nervosa    hypothyroidism    essential hypertension    pertussis
    hypertension    asthma    adenoma    hypoxia
    prostatitis    thyroiditis    obesity    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for ADRA1B:
    Ureterolithiasis     Ureter carcinoma

    ADRA1B for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ADRA1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperfunction 40.6 2 9004925 (1), 9754358 (1)
    cardiomyopathy 0 1 15674439 (1)
    heart failure 0 1 15674439 (1)

    Genetic Association Database (GAD): ADRA1B
    Human Genome Epidemiology (HuGE) Navigator: ADRA1B (15 documents)

    Export disorders for ADRA1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA1B gene, integrated from 10 sources (see all 237):
    (articles sorted by number of sources associating them with ADRA1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study on African-ancestry populations for asthma. (PubMed id 19910028)1, 4, 9 Mathias R.A....Barnes K.C. (J. Allergy Clin. Immunol. 2010)
    2. Genomic organization and expression of the human alpha 1B-adrenergic receptor. (PubMed id 1328250)1, 2, 9 Ramarao C.S....Graham R.M. (J. Biol. Chem. 1992)
    3. Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. (PubMed id 21063774)1, 4 Parkman H.P....Krynetskiy E. (Dig. Dis. Sci. 2011)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. (PubMed id 20857090)1, 7 Jensen B.C....Simpson P.C. (Naunyn Schmiedebergs Arch. Pharmacol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    9. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (Am. J. Respir. Crit. Care Med. 2010)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147 HGNC: 278 AceView: ADRA1B Ensembl:ENSG00000170214 euGenes: HUgn147
    ECgene: ADRA1B Kegg: 147 H-InvDB: ADRA1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADRA1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADRA1B gene:
    Search GeneIP for patents involving ADRA1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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