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Aliases for ADRA1B Gene

Aliases for ADRA1B Gene

  • Adrenoceptor Alpha 1B 2 3 5
  • Adrenergic, Alpha-1B-, Receptor 2 3
  • Alpha-1B Adrenoreceptor 3 4
  • Alpha-1B Adrenoceptor 3 4
  • Alpha-1B-Adrenergic Receptor 3
  • ALPHA1BAR 3
  • ADRA1 3

External Ids for ADRA1B Gene

Previous GeneCards Identifiers for ADRA1B Gene

  • GC05P159198
  • GC05P159853
  • GC05P159324
  • GC05P159276
  • GC05P154438
  • GC05P159343

Summaries for ADRA1B Gene

Entrez Gene Summary for ADRA1B Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1B Gene

ADRA1B (Adrenoceptor Alpha 1B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1B Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1B Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1B Gene

Genomics for ADRA1B Gene

Regulatory Elements for ADRA1B Gene

Promoters for ADRA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADRA1B on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA1B Gene

Chromosome:
5
Start:
159,916,733 bp from pter
End:
159,986,178 bp from pter
Size:
69,446 bases
Orientation:
Plus strand

Genomic View for ADRA1B Gene

Genes around ADRA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1B Gene

Proteins for ADRA1B Gene

  • Protein details for ADRA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35368-ADA1B_HUMAN
    Recommended name:
    Alpha-1B adrenergic receptor
    Protein Accession:
    P35368
    Secondary Accessions:
    • B0LPE1

    Protein attributes for ADRA1B Gene

    Size:
    520 amino acids
    Molecular mass:
    56836 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

neXtProt entry for ADRA1B Gene

Proteomics data for ADRA1B Gene at MOPED

Post-translational modifications for ADRA1B Gene

  • Glycosylation at Asn 10, Asn 24, Asn 29, and Asn 34
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ADRA1B (alpha-1B Adrenergic R/ADRA1B)

No data available for DME Specific Peptides for ADRA1B Gene

Domains & Families for ADRA1B Gene

Gene Families for ADRA1B Gene

Suggested Antigen Peptide Sequences for ADRA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35368

UniProtKB/Swiss-Prot:

ADA1B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
genes like me logo Genes that share domains with ADRA1B: view

Function for ADRA1B Gene

Molecular function for ADRA1B Gene

GENATLAS Biochemistry:
adrenergic,alpha-1B-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphatidylinositol/Ca2+ second messenger system,involved in the control of vascular tone
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Gene Ontology (GO) - Molecular Function for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004937 alpha1-adrenergic receptor activity IEA --
genes like me logo Genes that share ontologies with ADRA1B: view
genes like me logo Genes that share phenotypes with ADRA1B: view

Animal Models for ADRA1B Gene

MGI Knock Outs for ADRA1B:

Animal Model Products

miRNA for ADRA1B Gene

miRTarBase miRNAs that target ADRA1B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1B Gene

Localization for ADRA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1B Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA1B Gene COMPARTMENTS Subcellular localization image for ADRA1B gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0005887 integral component of plasma membrane TAS 1328250
genes like me logo Genes that share ontologies with ADRA1B: view

Pathways & Interactions for ADRA1B Gene

genes like me logo Genes that share pathways with ADRA1B: view

Gene Ontology (GO) - Biological Process for ADRA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 10820200
GO:0007267 cell-cell signaling TAS 1328250
GO:0043410 positive regulation of MAPK cascade IDA 22120526
GO:0045907 positive regulation of vasoconstriction IBA --
genes like me logo Genes that share ontologies with ADRA1B: view

No data available for SIGNOR curated interactions for ADRA1B Gene

Drugs & Compounds for ADRA1B Gene

(153) Drugs for ADRA1B Gene - From: IUPHAR, DGIdb, DrugBank, Novoseek, ApexBio, HMDB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methoxamine Approved Pharma Full agonist, Agonist, stimulator, Target, agonist 3
Phenylephrine Approved Pharma Full agonist, Agonist, agonist, Target 409
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 51
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 22
Risperidone Approved, Investigational Pharma Antagonist, antagonist, Target SR-2A inhibitor 477

(17) Additional Compounds for ADRA1B Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
Promazine 5-sulfoxide
(R)-(-)-Phenylephrine hydrochloride
61-76-7
A 61603 hydrobromide
107756-30-9
Cirazoline hydrochloride
40600-13-3
genes like me logo Genes that share compounds with ADRA1B: view

Transcripts for ADRA1B Gene

mRNA/cDNA for ADRA1B Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1B Gene

Adrenoceptor alpha 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1B Gene

No ASD Table

Relevant External Links for ADRA1B Gene

GeneLoc Exon Structure for
ADRA1B
ECgene alternative splicing isoforms for
ADRA1B

Expression for ADRA1B Gene

mRNA expression in normal human tissues for ADRA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1B Gene

This gene is overexpressed in Artery - Aorta (x7.3) and Liver (x4.1).

Protein differential expression in normal tissues from HIPED for ADRA1B Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRA1B Gene



SOURCE GeneReport for Unigene cluster for ADRA1B Gene Hs.368632

genes like me logo Genes that share expression patterns with ADRA1B: view

Protein tissue co-expression partners for ADRA1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADRA1B Gene

Orthologs for ADRA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADRA1B 35
  • 93.72 (n)
  • 97.28 (a)
ADRA1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRA1B 35
  • 92.94 (n)
  • 94.76 (a)
ADRA1B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra1b 35
  • 90.55 (n)
  • 96.31 (a)
Adra1b 16
Adra1b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADRA1B 35
  • 98.52 (n)
  • 98.45 (a)
ADRA1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra1b 35
  • 90.74 (n)
  • 95.73 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRA1B 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRA1B 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA1B 35
  • 68.89 (n)
  • 75.99 (a)
ADRA1B 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488806 35
  • 64.91 (n)
  • 65.07 (a)
zebrafish
(Danio rerio)
Actinopterygii adra1bb 35
  • 68.06 (n)
  • 70.23 (a)
ADRA1B (1 of 2) 36
  • 61 (a)
OneToMany
adra1bb 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 35 (a)
5-HT1B 37
  • 39 (a)
5-HT7 37
  • 32 (a)
CG6919 37
  • 37 (a)
CG6989 37
  • 35 (a)
CG7431 37
  • 44 (a)
DopR 37
  • 36 (a)
DopR2 37
  • 43 (a)
Oamb 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C52B11.3 37
  • 34 (a)
dop-4 36
  • 27 (a)
OneToMany
Species with no ortholog for ADRA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1B Gene

ENSEMBL:
Gene Tree for ADRA1B (if available)
TreeFam:
Gene Tree for ADRA1B (if available)

Paralogs for ADRA1B Gene

(19) SIMAP similar genes for ADRA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADRA1B: view

Variants for ADRA1B Gene

Sequence variations from dbSNP and Humsavar for ADRA1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs8192448 - 159,917,057(+) CCTGG(G/T)GCTGG reference, missense
rs756275 -- 159,924,453(-) CTCCC(A/G)TTTTC intron-variant
rs925995 -- 159,925,301(+) AATTG(C/G)GTCGT intron-variant
rs952037 -- 159,963,870(+) TTTGA(C/T)CCTTG intron-variant
rs952038 -- 159,964,019(+) AAATG(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1B Gene

Variant ID Type Subtype PubMed ID
nsv462500 CNV Loss 19166990
nsv830531 CNV Loss 17160897
esv22831 CNV Loss 19812545

Variation tolerance for ADRA1B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA1B Gene

HapMap Linkage Disequilibrium report
ADRA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1B Gene

Disorders for ADRA1B Gene

Relevant External Links for ADRA1B

Genetic Association Database (GAD)
ADRA1B
Human Genome Epidemiology (HuGE) Navigator
ADRA1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA1B

No disorders were found for ADRA1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADRA1B Gene

Publications for ADRA1B Gene

  1. A genome-wide association study on African-ancestry populations for asthma. (PMID: 19910028) Mathias R.A. … Barnes K.C. (J. Allergy Clin. Immunol. 2010) 3 23 48 67
  2. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. (PMID: 20857090) Jensen B.C. … Simpson P.C. (Naunyn Schmiedebergs Arch. Pharmacol. 2010) 3 25
  3. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. (PMID: 20030735) Haenisch B. … BAPnisch H. (Fundam Clin Pharmacol 2010) 25 26
  4. Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists. (PMID: 20412040) Du L. … Li M. (Curr Comput Aided Drug Des 2010) 25 26
  5. Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. (PMID: 18523139) Stanasila L. … Cotecchia S. (Mol. Pharmacol. 2008) 3 23

Products for ADRA1B Gene

Sources for ADRA1B Gene

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