ADRA1A Gene
protein-coding GIFtS: 68
GCID: GC08M026605
|
|
adrenoceptor alpha 1A(Previous names: adrenergic, alpha-1A-, receptor )
(Previous symbol: ADRA1C)
| |
Aliases
for ADRA1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adrenoceptor Alpha 1A1 2 | | Adrenergic, Alpha-1A-, Receptor Variant 12 | | ADRA1C1 2 3 5 | | Adrenergic, Alpha-1A-, Receptor Variant 32 | | ADRA1L11 2 | | Adrenergic, Alpha-1A-, Receptor Variant 52 | | Alpha-1A Adrenoceptor2 3 | | Adrenergic, Alpha-1A-, Receptor Variant 82 | | Alpha-1A Adrenoreceptor2 3 | | Alpha-1A Adrenergic Receptor2 | | Alpha-1C Adrenergic Receptor2 3 | | G Protein Coupled Receptor2 | | Adrenergic, Alpha-1A-, Receptor1 | | Alpha-Adrenergic Receptor 1c3 | | ALPHA1AAR2 | | |
Export aliases for ADRA1A gene to outside databasesPrevious GC identifers: GC08M026378 GC08M027048 GC08M026627 GC08M026661 GC08M025150 |
Summaries
for ADRA1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADRA1A:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activatemitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A,-1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patternsof activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates fourtranscript variants, which encode four different isoforms with distinct C-termini but having similar ligand bindingproperties. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate aphosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. NuclearADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes
 summary
for ADRA1A: Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The
adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.
lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in
smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L
based on its low affinity for prazosin. It has been suggested that this subtype may represent a different
conformational state of the alpha1A subtype.
Gene Wiki entry for ADRA1A (Alpha-1A adrenergic receptor)
|
Genomic Views
for ADRA1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADRA1A gene promoter:
AML1a FOXJ2 (long isoform) CUTL1 FOXJ2 Nkx2-5 E47 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADRA1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADRA1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2ADRA1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M026605: view genomic region
(about GC identifiers)
Start:
|
26,605,667 bp from pter |
End:
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26,724,790 bp from pter |
Size:
|
119,124 bases |
Orientation:
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minus strand |
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Proteins
for ADRA1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348 (See
protein sequence)Recommended Name: Alpha-1A adrenergic receptor Size: 466 amino acids; 51487 Da
Subunit: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling incardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
Secondary accessions: A8K0I3 B0ZBD1 B0ZBD2 B0ZBD4 B0ZBD5 B0ZBD6 B0ZBD8 B0ZBD9 O60451 Q13675 Q13729Q4VBM7 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8 Q6RUJ9 Q96RE8 Q9UD63 Q9UD67Alternative splicing: 9 isoforms: P35348-1 P35348-2 P35348-3 P35348-4 P35348-5 P35348-6 P35348-7 P35348-8 P35348-9 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for ADRA1A: NX_P35348
Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35348
ADRA1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_000671.2 NP_150645.2 NP_150646.3 NP_150647.2
ENSEMBL proteins: ENSP00000369960 ENSP00000431073 ENSP00000369956 ENSP00000430414 ENSP00000430793 ENSP00000346557 ENSP00000276393 ENSP00000369947 ENSP00000369946 ENSP00000369961 ENSP00000369955 ENSP00000351725 Reactome Protein details: P35348
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
ADRA1A for ontologies About GeneDecksing
ADRA1A Antibody Products:
Assay Products for ADRA1A: |
Protein
Domains /
Families
for ADRA1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADRA1A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35348ProtoNet protein and cluster: P35348 2 Blocks protein families: IPB001004 Alpha-1C adrenergic receptor signature IPB002233 Adrenergic receptor signature
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily |
Function
for ADRA1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate aphosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. NuclearADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes Genatlas biochemistry entry for ADRA1A:adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively splicedisoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004937 | alpha1-adrenergic receptor activity |
TAS | 7737411 | | GO:0046982 | protein heterodimerization activity |
IDA | -- |
ADRA1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADRA1A:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Adra1a):
ADRA1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADRA1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translation_Translation regulation by Alpha-1 adrenergic receptors | | | 2 | Class A/1 (Rhodopsin-like receptors) | | | 3 | Activation of cAMP-Dependent PKA | | | 4 | Signaling by GPCR | | | 5 | G alpha (q) signalling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ADRA1A
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADRA1A (see all 6)
2  GeneGo (Thomson Reuters) Pathways for ADRA1A
5  BioSystems Pathways for ADRA1A
5/10 
Reactome Pathways for ADRA1A (see all 10)
1  PharmGKB Pathway for ADRA1A
4 
Kegg Pathways (Kegg details for ADRA1A):
ADRA1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRA1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/18 Interacting proteins for ADRA1A (P353483 ENSP000003699604) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001985 | negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure |
IEA | -- | | GO:0001994 | norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure |
IEA | -- | | GO:0001996 | positive regulation of heart rate by epinephrine-norepinephrine |
IEA | -- | | GO:0001997 | positive regulation of the force of heart contraction by epinephrine-norepinephrine |
IEA | -- | | GO:0003084 | positive regulation of systemic arterial blood pressure |
IEA | -- |
ADRA1A for ontologies About GeneDecksing
|
Drugs & Compounds
for ADRA1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADRA1A for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for ADRA1A |
Compounds for ADRA1A available from Tocris Bioscience About this table
7 HMDB Compounds for ADRA1A About this table
10/74 DrugBank Compounds for ADRA1A (see all 74) About this table
3 Novoseek chemical compound relationships for ADRA1A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prazosin |
52.9 |
1 |
12782672 (1) |
| norepinephrine |
14 |
1 |
16756025 (1) |
| dopamine |
0 |
1 |
8383880 (1) |
Search CenterWatch for drugs/clinical trials and news about ADRA1A / ADA1A
|
Transcripts
for ADRA1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADRA1A gene (4 alternative transcripts): NM_000680.2 NM_033302.2 NM_033303.3 NM_033304.2 Unigene Cluster for ADRA1A: Adrenoceptor alpha 1A Hs.709175 [show with all ESTs]Unigene Representative Sequence: AK28954814 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380586(uc003xfc.1) ENST00000519096(uc003xfd.1) ENST00000380582(uc003xfe.1)
ENST00000521711(uc010lum.1 uc003xff.1) ENST00000519229 ENST00000354550(uc003xfg.1)
ENST00000276393(uc003xfh.1) ENST00000380573(uc010lun.1) ENST00000518621
ENST00000380572 ENST00000518810 ENST00000380587(uc010lul.1) ENST00000380581
ENST00000358857
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1A (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADRA1A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): ADRA1A (NM_033303) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADRA1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1A |
Additional cDNA sequence: AF013261.1 AF395806.1 AK289548.1 AK311558.1 AY491775.1 AY491776.1 AY491777.1 AY491778.1 AY491781.1 BC095512.1 D25235.1 D32201.1 D32202.1 L31774.1 S76001.1 U02569.1 8 DOTS entries: DT.456038 DT.95193429 DT.95193430 DT.99953072 DT.102825087 DT.87046229 DT.95261826 DT.97798254 24 AceView cDNA sequences: D32201 L31774 NM_033302 AY491778 AF013261 AA383171 AY491775 D25235 NM_033303 CF147810 AY491780 U02569 NM_000680 AY491776 AY491777 D32202 AA312801 NM_033304 AF395806 S76001 AA345702 AY491781 AV654179 AW956748
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | |
| SP2: | | | | | - | | | | - | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for ADRA1A
|
Expression
for ADRA1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADRA1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCAGTGCT
About this image
See ADRA1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADRA1A
SOURCE GeneReport for Unigene cluster: Hs.709175
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta andpituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the mostabundant isoform expressed in the prostate with high levels also detected in liver and heart
SABiosciences Expression via Pathway-Focused PCR Arrays including ADRA1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADRA1A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADRA1A |
Orthologs
for ADRA1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADRA1A gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADRA1A1 |
adrenoceptor alpha 1A |
73.75(n)
77.25(a) |
|
428203 XM_425762.2 XP_425762.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ADRA1A6 |
-- |
68(a) |
1 ↔ 1 |
GL343445.1(418736-446010) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7984981 |
alpha-1A adrenergic receptor-like |
60.45(n)
62.92(a) |
|
798498 XM_001338902.3 XP_001338938.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
C52B11.33
dop-41 |
G-protein coupled receptor3
Protein DOP-41 |
38(a)3
46.69(n)1
41.52(a)1 |
|
X(1330197-1335711)3
1837151 NM_075837.21 NP_508238.21 |
ENSEMBL Gene Tree for ADRA1A (if available)
TreeFam Gene Tree for ADRA1A (if available) |
Paralogs
for ADRA1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADRA1A gene
- DRD42 HTR1A2 ADRA1B2 DRD22 HTR1F2 HTR72 ADRA2C2 ADRA2A2
- HTR1D2 ADRA2B2 HTR1E2 DRD32 HTR5A2 HTR1B2 ADRA1D2
18/51 SIMAP similar genes for ADRA1A using alignment to 3 protein entries: ADA1A_HUMAN (see all proteins)
(see all similar genes):alpha 1c-adrenoceptor subtype ADRA1C KIAA1651 HC6 ADRA1B ADRA1D
5-HT7 COQ5 SH2B3 SNRPF pp12301 MST132
FCER1G TUBA1C HRH3 HTR2A HTR2C PFKFB3
ADRA1A for paralogs About GeneDecksing
|
Genomic Variants
for ADRA1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADRA1A (26605667 - 26724790 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADRA1A: --
Human Gene Mutation Database (HGMD): ADRA1A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADRA1A |
|
Disorders
/ Diseases
for ADRA1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADRA1A for disorders About GeneDecksing
OMIM gene information: 104221
OMIM disorders: --
20/29  diseases for ADRA1A (see all 29): About MalaCardsgilles de la tourette syndrome attention deficit hyperactivity disorder complex regional pain syndrome major depressive disorder
bipolar affective disorder tourette syndrome ureter carcinoma ureterolithiasis
urethral obstruction paine syndrome urethritis schizoaffective disorder
coronary heart disease gastroparesis syncope fibromyalgia
prostatic hypertrophy adhd parkinson's disease aldosteronism
2 diseases from the University of Copenhagen DISEASES database for ADRA1A:Ureterolithiasis Prostatic hypertrophy 2 Novoseek disease relationships for ADRA1A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| benign prostatic hyperplasia |
58.7 |
4 |
10843225 (1), 11055359 (1), 16536786 (1), 8183249 (1) |
| attention-deficit hyperactivity disorder |
24.1 |
1 |
11326305 (1) |
Genetic Association Database (GAD): ADRA1A
Human Genome Epidemiology (HuGE) Navigator: ADRA1A (50 documents)
Export disorders for ADRA1A gene to outside databases
|
Publications
for ADRA1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADRA1A gene, integrated from 9 sources (see all 262):
(articles sorted by number of sources associating them with ADRA1A) | |  | Utopia: connect your pdf to the dynamic
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- Alpha 1A-adrenergic receptor polymorphism and vascular response. (PubMed id 15179408)1, 2, 4 Sofowora G.G.... Stein C.M. (2004)
- Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. (PubMed id 8832064)1, 2, 4 Shibata K....Tsujimoto G. (1996)
- Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. (PubMed id 8396931)1, 2, 9 Hirasawa A....Tsujimoto G. (1993)
- Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. (PubMed id 10493934)1, 2, 9 Coge F.... Canet E. (1999)
- The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)1, 2, 9 Forray C.... Gluchowski C. (1994)
- Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PubMed id 16043131)1, 4, 9 Clark D.A....Kerwin R.W. (2005)
- The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)1, 4, 9 Matayoshi T....Kawano Y. (2004)
- Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (PubMed id 12519093)1, 4, 9 Snapir A....Scheinin M. (2003)
- Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects. (PubMed id 16153395)1, 4 Jiang S....Wang X. (2005)
- A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. (PubMed id 15136785)1, 4 Klotsman M....Hartmann K.E. (2004)
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External Searches for ADRA1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ADRA1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ADRA1A gene
(According to HUGE)
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Specialized Databases showing ADRA1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ADRA1A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ADRA1A gene:
Search GeneIP for patents involving ADRA1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADRA1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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