Aliases for ADRA1A Gene
External Ids for ADRA1A Gene
Previous HGNC Symbols for ADRA1A Gene
Previous GeneCards Identifiers for ADRA1A Gene
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA1A Gene
ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include Horner's Syndrome and Prostatic Hypertrophy. Among its related pathways are Vascular smooth muscle contraction and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.
UniProtKB/Swiss-Prot for ADRA1A Gene
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.