Aliases for ADRA1A Gene
- Adrenoceptor Alpha 1A 2 3
- ADRA1C 3 4 6
- Alpha-1C Adrenergic Receptor 3 4
- Alpha-1A Adrenoreceptor 3 4
- Alpha-1A Adrenoceptor 3 4
- Adrenergic, Alpha-1A-, Receptor Variant 11 3
- Adrenergic, Alpha-1A-, Receptor Variant 1 3
- Adrenergic, Alpha-1A-, Receptor Variant 3 3
- Adrenergic, Alpha-1A-, Receptor Variant 5 3
External Ids for ADRA1A Gene
Previous Symbols for ADRA1A Gene
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA1A Gene
ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include ureterolithiasis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein heterodimerization activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for ADRA1A Gene
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.