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ADRA1A Gene

protein-coding   GIFtS: 69
GCID: GC08M026605

Adrenoceptor Alpha 1A

(Previous names: adrenergic, alpha-1A-, receptor)
(Previous symbol: ADRA1C)
  See ADRA1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adrenoceptor Alpha 1A1 2     Adrenergic, Alpha-1A-, Receptor Variant 12
ADRA1C1 2 3 5     Adrenergic, Alpha-1A-, Receptor Variant 112
Alpha-1A Adrenoceptor2 3     Adrenergic, Alpha-1A-, Receptor Variant 32
Alpha-1A Adrenoreceptor2 3     Adrenergic, Alpha-1A-, Receptor Variant 52
Alpha-1C Adrenergic Receptor2 3     Adrenergic, Alpha-1A-, Receptor Variant 82
Adrenergic, Alpha-1A-, Receptor1     Alpha-1A Adrenergic Receptor2
ADRA1L12     G Protein Coupled Receptor2
ALPHA1AAR2     Alpha-Adrenergic Receptor 1c3

External Ids:    HGNC: 2771   Entrez Gene: 1482   Ensembl: ENSG000001209077   OMIM: 1042215   UniProtKB: P353483   

Export aliases for ADRA1A gene to outside databases

Previous GC identifers: GC08M026378 GC08M027048 GC08M026627 GC08M026661 GC08M025150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADRA1A Gene:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They
activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR
subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different
subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative
splicing of this gene generates four transcript variants, which encode four different isoforms with distinct
C-termini but having similar ligand binding properties. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADRA1A Gene:
ADRA1A (adrenoceptor alpha 1A) is a protein-coding gene. Diseases associated with ADRA1A include ureterolithiasis, and attention deficit hyperactivity disorder. GO annotations related to this gene include protein heterodimerization activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear
ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes

summary for ADRA1A Gene:
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The
adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.
lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in
smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L
based on its low affinity for prazosin. It has been suggested that this subtype may represent a different
conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1A (Alpha-1A adrenergic receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ADRA1A gene promoter:
         AML1a   FOXJ2 (long isoform)   CUTL1   FOXJ2   Nkx2-5   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ADRA1A promoter sequence
   Search Chromatin IP Primers for ADRA1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADRA1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

ADRA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA1A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M026605:  view genomic region     (about GC identifiers)

Start:
26,605,667 bp from pter      End:
26,724,790 bp from pter
Size:
119,124 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348 (See protein sequence)
Recommended Name: Alpha-1A adrenergic receptor  
Size: 466 amino acids; 51487 Da
Subunit: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes
Secondary accessions: A8K0I3 B0ZBD1 B0ZBD2 B0ZBD4 B0ZBD5 B0ZBD6 B0ZBD8 B0ZBD9 O60451 Q13675
Q13729 Q4VBM7 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8 Q6RUJ9 Q96RE8 Q9UD63 Q9UD67
Alternative splicing: 9 isoforms:  P35348-1   P35348-2   P35348-3   P35348-4   P35348-5   P35348-6   P35348-7   P35348-8   
P35348-9   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADRA1A: NX_P35348

Explore proteomics data for ADRA1A at MOPED

Post-translational modifications: 

  • C-terminal Ser or Thr residues may be phosphorylated (By similarity)1
  • Glycosylation2 at Asn7, Asn13, Asn22
  • Modification sites at PhosphoSitePlus

  • See ADRA1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000671.2  NP_150645.2  NP_150646.3  NP_150647.2  

    ENSEMBL proteins: 
     ENSP00000369960   ENSP00000431073   ENSP00000369956   ENSP00000430414   ENSP00000430793  
     ENSP00000346557   ENSP00000276393   ENSP00000369947   ENSP00000369946   ENSP00000369961  
     ENSP00000369955   ENSP00000351725  
    Reactome Protein details: P35348

    ADRA1A Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for ADRA1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADRA: GPCR / Class A : Adrenoceptors : alpha

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha1A-adrenoceptor
    Adrenoceptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 ADR_fam
     IPR000276 GPCR_Rhodpsn
     IPR001004 ADRA1A_rcpt

    Graphical View of Domain Structure for InterPro Entry P35348

    ProtoNet protein and cluster: P35348

    2 Blocks protein domains:
    IPB001004 Alpha-1C adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A
    sub-subfamily


    Find genes that share domains with ADRA1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA1A_HUMAN, P35348
    Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
    phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear
    ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes

         Genatlas biochemistry entry for ADRA1A:
    adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced
    isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004937alpha1-adrenergic receptor activity TAS7737411
    GO:0046982protein heterodimerization activity IDA--
         
    Find genes that share ontologies with ADRA1A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADRA1A:
     Decreased substrate adherent c  PARP inhibitor sensitization 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adra1a):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 
     renal/urinary system 

    Find genes that share phenotypes with ADRA1A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADRA1A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADRA1A
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    miRTarBase miRNAs that target ADRA1A:
    hsa-mir-484 (MIRT041983)

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    4 qRT-PCR Assays for microRNAs that regulate ADRA1A:
    hsa-miR-3163 hsa-miR-433 hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidADRA1A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADRA1A

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    GenScript: all cDNA clones in your preferred vector (see all 4): ADRA1A (NM_033303)
    Sino Biological Human cDNA Clone for ADRA1A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADRA1A

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    eBioscience FlowRNA Probe Sets ( VA1-10215) for ADRA1A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA1A_HUMAN, P35348: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in
    cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8396931
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ADRA1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADRA1A About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Adrenoceptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90


    Find genes that share SuperPaths with ADRA1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADRA1A (see all 6)
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    cAMP Pathway
    Activation of cAMP-Dependent PKA
    Signaling Involved in Cardiac Hypertrophy

    2 GeneGo (Thomson Reuters) Pathways for ADRA1A
        Development Activation of ERK by Alpha-1 adrenergic receptors
    Translation Translation regulation by Alpha-1 adrenergic receptors

    5 BioSystems Pathways for ADRA1A
        AMPK signaling
    Calcium Regulation in the Cardiac Cell
    GPCRs, Class A Rhodopsin-like
    Endothelin
    Monoamine GPCRs


    3 Reactome Pathways for ADRA1A
        G alpha (12/13) signalling events
    G alpha (q) signalling events
    Adrenoceptors

    1 PharmGKB Pathway for ADRA1A
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    5 Kegg Pathways  (Kegg details for ADRA1A):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Adrenergic signaling in cardiomyocytes
    Vascular smooth muscle contraction
    Salivary secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADRA1A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADRA1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ADRA1A (P353483 ENSP000003699604) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1P134973, ENSP000003057144I2D: score=3 STRING: ENSP00000305714
    ABRQ129793, ENSP000003039094I2D: score=2 STRING: ENSP00000303909
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    CXCR1P250243, ENSP000002956834I2D: score=1 STRING: ENSP00000295683
    CXCR2P250253, ENSP000003196354I2D: score=1 STRING: ENSP00000319635
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001985negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA--
    GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA--
    GO:0001996positive regulation of heart rate by epinephrine-norepinephrine IEA--
    GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA--
    GO:0003084positive regulation of systemic arterial blood pressure IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADRA1A
      Browse compounds at ApexBio 

    Compounds for ADRA1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 100329 hydrochloride Potent, subtype-selective alpha1A antagonist [232953-52-5]
    RS 17053 hydrochloridealpha1A antagonist[169505-93-5]
    Cirazoline hydrochlorideSelective alpha1 agonist[40600-13-3]
    (R)-(-)-Phenylephrine hydrochloridealpha1 agonist[61-76-7]
    A 61603 hydrobromidealpha1A agonist[107756-30-9]

    7 HMDB Compounds for ADRA1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--
    PhenylephrineAdrianol (see all 60)59-42-7--
    PhenylpropanolamineDL-Norephedrine (see all 12)154-41-6--
    Pseudoephedrine(+)-(1S,2S)-Pseudoephedrine (see all 25)90-82-4--
    RisperidoneBelivon (see all 7)106266-06-2--

    Selected DrugBank Compounds for ADRA1A (see all 79)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alfuzosin-- 81403-80-7targetantagonist9122046 15639685 11750253 12892027 9870119 11752352 16553574 9223558 8196478 16613526 8799556
    DoxazosinDoxazosin mesilate (see all 2)74191-85-8targetantagonist16225542 11752352 19002123 15573147 14767264 10393471 9205965 17070143 8736427
    Paliperidone-- 144598-75-4targetantagonist8925876 18542932 15992090 15907153 7531353 7524043 7691623 11132243
    PrazosinPrazocin (see all 6)19216-56-9targetantagonist10771044 7855217 8925876 14980979 12841945 15258254 7691623 17658513
    Tamsulosin-- 106133-20-4targetantagonist10503165 8647140 8647141 9352700 19427736 11752352 9352698 14680444
    ApraclonidineApraclonidina [INN-Spanish] (see all 4)66711-21-5targetagonist17572343 16935593 17824139 15937427 18454417 16921219 20399934
    LabetalolLabetalol HCL (see all 4)36894-69-6targetantagonist1358746 17686376 17139284 6355664 17016423 7684671 8104240
    Naphazoline-- 835-31-4targetagonist10459292 10381812 16083326 10481510 8930173 11180982
    Risperidonerisperdone (see all 3)106266-06-2targetantagonist8925876 18542932 15992090 15907153 7691623 11132243
    TerazosinAbbott 45975 (see all 8)63590-64-7targetantagonist10503165 9732824 9352700 11752352 14767264 8736427

    Selected IUPHAR Ligands for ADRA1A (alpha1A-adrenoceptor) (see all 42)    About this table
    LigandTypeActionAffinityPubmed IDs
    tamsulosin
    AntagonistAntagonist10 - 10.79490024 7651358 10334511 9249248 10369480
    silodosin
    AntagonistAntagonist10.47651358
    NAN 190
    AntagonistAntagonist10.111459121
    (+)-niguldipine
    AntagonistAntagonist9.1 - 109249248 7651358
    [125I]HEAT
    AgonistFull agonist107651358
    prazosin
    AntagonistInverse agonist9 - 9.99490024 7651358 10334511 9249248 10369480
    [125I]BE-2254
    AntagonistAntagonist9.97815325 11337028
    WB 4101
    AntagonistAntagonist9.7 - 9.89490024 7651358 10334511 9249248
    Rec 15/2739
    AntagonistAntagonist9.69249248
    RS-100329
    AntagonistAntagonist9.610369480

    3 Novoseek inferred chemical compound relationships for ADRA1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prazosin 52.9 1 12782672 (1)
    norepinephrine 14 1 16756025 (1)
    dopamine 0 1 8383880 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADRA1A gene (4 alternative transcripts): 
    NM_000680.2  NM_033302.2  NM_033303.3  NM_033304.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380586(uc003xfc.1) ENST00000519096(uc003xfd.1) ENST00000380582(uc003xfe.1)
    ENST00000521711(uc010lum.1 uc003xff.1) ENST00000519229 ENST00000354550(uc003xfg.1)
    ENST00000276393(uc003xfh.1) ENST00000380573(uc010lun.1) ENST00000518621
    ENST00000380572 ENST00000518810 ENST00000380587(uc010lul.1) ENST00000380581
    ENST00000358857
    miRNA
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    24 AceView cDNA sequences:

    D32201 NM_033302 AY491778 L31774 AY491776 AA312801 S76001 D25235 
    D32202 AY491777 AY491780 AF013261 U02569 AY491775 NM_000680 NM_033304 
    AF395806 NM_033303 AA383171 CF147810 AV654179 AY491781 AA345702 AW956748 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:              -           -     -         
    SP2:              -           -               
    SP3:              -     -     -     -         
    SP4:                                          
    SP5:              -                           


    ECgene alternative splicing isoforms for ADRA1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADRA1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCAGTGCT
    ADRA1A Expression
    About this image


    ADRA1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Liver (Hepatobiliary System)
    ADRA1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADRA1A Protein Expression

    UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
    Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and
    pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most
    abundant isoform expressed in the prostate with high levels also detected in liver and heart

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADRA1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adra1a1 , 5 adrenergic receptor, alpha 1a1, 5 87.12(n)1
    91.85(a)1
      14 (34.60 cM)5
    115491  NM_013461.41  NP_038489.21 
     666352515 
    chicken
    (Gallus gallus)
    Aves ADRA1A1 adrenoceptor alpha 1A 73.75(n)
    77.25(a)
      428203  XM_425762.3  XP_425762.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADRA1A6
    adrenoceptor alpha 1A
    68(a)
    1 ↔ 1
    GL343445.1(417938-448559)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004927761 alpha-1A adrenergic receptor-like 65.52(n)
    69.18(a)
      100492776  XM_002932966.2  XP_002933012.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7984981 alpha-1A adrenergic receptor-like 60.48(n)
    62.86(a)
      798498  XM_001338902.4  XP_001338938.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23
    Oamb1
    dopamine receptor signaling pathway
    dopamine receptor3
    Octopamine receptor in mushroom bodies1
    44(a)
    (best of 6)3
    55.94(n)1
    45.86(a)1
      3 99B53
    439821  NM_169914.11  NP_732542.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C52B11.33
    dop-41
    G-protein coupled receptor3
    dop-41
    38(a)3
    46.51(n)1
    41.28(a)1
      X(1330197-1335711)3
    1837151  NM_075837.21  NP_508238.21 


    ENSEMBL Gene Tree for ADRA1A (if available)
    TreeFam Gene Tree for ADRA1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADRA1A gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for ADRA1A using alignment to 3 protein entries:     ADA1A_HUMAN (see all proteins) (see all similar genes):
    alpha 1c-adrenoceptor subtype    ADRA1C    KIAA1651    HC6    ADRA1B    ADRA1D
    5-HT7    COQ5    SH2B3    SNRPF    pp12301    MST132
    FCER1G    TUBA1C    HRH3    HTR2A    HTR2C    PFKFB3

    Find genes that share paralogs with ADRA1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADRA1A (see all 2861)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357564
    A breast cancer sample4--see VAR_0357562 G W mis40--------
    rs286474551,2
    --25186405(+) CACAAG/TGGGGG 4 -- int10--------
    rs3720726641,2
    C--25240083(+) gtctc-/AA    
       
    /AAAA
    aaaaa
    4 -- int10--------
    rs349232191,2
    C--26605958(-) TTTTT-/TATCTT 1 -- ut310--------
    rs358845871,2
    C--26606268(+) AAAAA-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs617597001,2
    C,F--26606969(+) TTATGT/-TTTTC 1 -- int11Minor allele frequency- -:0.06NS 554
    rs624921651,2
    C,F--26610018(+) CTGCCG/AGCATT 1 -- int14Minor allele frequency- A:0.09NA WA 242
    rs32150801,2
    C--26610968(+) TTCTA-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs617597081,2
    C--26613995(+) AAAAA-/ATCGAG 2 -- int1 ut312Minor allele frequency- A:0.20NS CSA 562
    rs358389481,2
    C--26629635(+) TGGGCT/-TTTTT 4 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for ADRA1A (26605667 - 26724790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADRA1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527478CNV Gain19592680

    Human Gene Mutation Database (HGMD): ADRA1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADRA1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ADRA1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 104221    OMIM disorders: --

    2 diseases for ADRA1A:    
    About MalaCards
    ureterolithiasis    attention deficit hyperactivity disorder

    2 diseases from the University of Copenhagen DISEASES database for ADRA1A:
    Ureterolithiasis     Prostatic hypertrophy

    Find genes that share disorders with ADRA1A           About GenesLikeMe

    2 Novoseek inferred disease relationships for ADRA1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benign prostatic hyperplasia 58.7 4 10843225 (1), 11055359 (1), 16536786 (1), 8183249 (1)
    attention-deficit hyperactivity disorder 24.1 1 11326305 (1)

    Genetic Association Database (GAD): ADRA1A
    Human Genome Epidemiology (HuGE) Navigator: ADRA1A (50 documents)

    Export disorders for ADRA1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADRA1A gene, integrated from 10 sources (see all 271):
    (articles sorted by number of sources associating them with ADRA1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alpha 1A-adrenergic receptor polymorphism and vascular response. (PubMed id 15179408)1, 2, 4 Sofowora G.G.... Stein C.M. (Clin. Pharmacol. Ther. 2004)
    2. Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. (PubMed id 8832064)1, 2, 4 Shibata K....Tsujimoto G. (Br. J. Pharmacol. 1996)
    3. Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. (PubMed id 8396931)1, 2, 9 Hirasawa A....Tsujimoto G. (Biochem. Biophys. Res. Commun. 1993)
    4. Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. (PubMed id 10493934)1, 2, 9 Coge F.... Canet E. (Biochem. J. 1999)
    5. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)1, 2, 9 Forray C.... Gluchowski C. (Mol. Pharmacol. 1994)
    6. Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. (PubMed id 16536786)1, 4, 9 Mochtar C.A....Kiemeney L.A. (BJU Int. 2006)
    7. Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients. (PubMed id 19476811)1, 4, 9 Morris J.A....Canter J.A. (J. Am. Coll. Surg. 2009)
    8. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PubMed id 16043131)1, 4, 9 Clark D.A....Kerwin R.W. (Biol. Psychiatry 2005)
    9. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)1, 4, 9 Matayoshi T....Kawano Y. (Hypertens. Res. 2004)
    10. Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (PubMed id 12519093)1, 4, 9 Snapir A....Scheinin M. (Clin. Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 148 HGNC: 277 AceView: ADRA1A Ensembl:ENSG00000120907 euGenes: HUgn148
    ECgene: ADRA1A Kegg: 148 H-InvDB: ADRA1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADRA1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADRA1A gene:
    Search GeneIP for patents involving ADRA1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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