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ADRA1A Gene

protein-coding GIFtS: 69

GC08M026661

adrenergic, alpha-1A-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADRA1C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADRA1C ^², ³
ADRA1D ^⁵
ADRA1L1 ^¹, ²
ALPHA1AAR ^²
OTTHUMP00000125313 ^²

Descriptions
Alpha 1A-adrenoceptor ^³
Alpha 1A-adrenoreceptor ^³
Alpha-1C adrenergic receptor ^³
Alpha-adrenergic receptor 1c ^³
G protein coupled receptor ^²
adrenergic, alpha -1A-, receptor ^²
adrenergic, alpha-1A-, receptor ^²
adrenergic, alpha-1A-, receptor variant 1 ^²
adrenergic, alpha-1A-, receptor variant 3 ^²
adrenergic, alpha-1A-, receptor variant 5 ^²
adrenergic, alpha-1A-, receptor variant 8 ^²
adrenergic, alpha-1C-, receptor ^²
alpha-1A-adrenergic receptor ^²

External Ids
HGNC: 277¹
Entrez Gene: 148²
UniProtKB: P35348³
Ensembl: ENSG00000120907⁷

Search outside databases for aliases for ADRA1A gene

Previous GC identifers: GC08M026378 GC08M027048 GC08M026627

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADRA1A:

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor

superfamily. They activate mitogenic responses and regulate growth and proliferation of many

cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the

Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene

encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript

variants, which encode four different isoforms with distinct C-termini but having similar ligand

binding properties. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q)

and G(11) proteins

Gene Wiki entry for ADRA1A (Alpha-1A_adrenergic_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADRA1A gene

Entrez Gene cytogenetic band: 8p21-p11.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.2

ADRA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M026661: (about GC identifiers)

Start:	26,661,584 bp from pter
End:	26,778,839 bp from pter
Size:	117,256 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_023666.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348 (See protein sequence)

Recommended Name: Alpha-1A adrenergic receptor

Size: 466 amino acids; 51487 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B0ZBD1 B0ZBD4 B0ZBD5 B0ZBD9 O60451 Q13675 Q13729 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8

Q6RUJ9 Q9UD63

Alternative splicing: 9 isoforms: P35348-1 P35348-2 P35348-3 P35348-4 P35348-5 P35348-6 P35348-7 P35348-8

P35348-9

Post-translational modifications:

Carboxyl-terminal Ser or Thr residues may be phosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000671.2 NP_150645.2 NP_150646.3 NP_150647.2

ENSEMBL proteins:

ENSP00000346557 ENSP00000369947 ENSP00000351725 ENSP00000369956 ENSP00000369946 ENSP00000276393

ENSP00000369955 ENSP00000369960 ENSP00000348729 ENSP00000369961

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADRA1A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 1c Adrenergic Receptor, alpha 1 Adrenergic Receptor)
	Human Recombinant Proteins from Abnova (ADRA1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8396931

About this table

Antibodies for ADRA1A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADRA1A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (alpha 1c Adrenergic Receptor, alpha 1 Adrenergic Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADRA1A)
	Novus Biologicals Antibodies for ADRA1A

Assays for ADRA1A:

	Invitrogen Assays for ADRA1A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35348

ProtoNet protein and cluster: P35348

2 Blocks protein families:

IPB001004 Alpha-1C adrenergic receptor signature

IPB002233 Adrenergic receptor signature

UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033303

Applied Biosystems Silencer® siRNAs for ADRA1A

Sigma-Aldrich siRNA and siRNA Panels for ADRA1A

Sigma-Aldrich shRNA Panels and shRNA for ADRA1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of ADRA1A

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000680
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000680
untagged cDNA clones in CMV expression vector (see all 4): NM_000680

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_033303

UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348

Function: This alpha-adrenergic receptor mediates its action by association with G proteins that

activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q)

and G(11) proteins

Genatlas biochemistry entry for ADRA1A:

adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced

isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra1a):

homeostasis/metabolism

life span-post-weaning/aging

muscle

renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004935	adrenoceptor activity	IEA	--
GO:0004937	alpha1-adrenergic receptor activity	TAS	7737411

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ADRA1A (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
Cardiac Hypertrophy Signaling
&alpha

GeneDecks ADRA1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADRA1A

5/12 Interacting proteins for ADRA1A (ENSP00000348729³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRA1B	ENSP00000306662³	STRING (score=.963)
ADRA1D	ENSP00000368766³	STRING (score=.962)
GNAQ	ENSP00000286548³	STRING (score=.877)
GNA11	ENSP00000078429³	STRING (score=.824)
ADRB2	ENSP00000305372³	STRING (score=.82)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	TAS	10671514
GO:0006939	smooth muscle contraction	TAS	8183249
GO:0007165	signal transduction	TAS	8396931
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	10860850
GO:0007243	protein kinase cascade	TAS	10671514

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADRA1A

Sigma-Aldrich Small Molecules for ADRA1A:

Antagonist Agonist Inhibitor

Compounds for ADRA1A available from Tocris Bioscience

Compound	Action	CAS number
RS 100329 hydrochloride	Potent, subtype selective alpha1A antagonist	[232953-52-5]
RS 17053 hydrochloride	alpha1A antagonist	[169505-93-5]
Cirazoline hydrochloride	Selective alpha1 agonist	[40600-13-3]
SNAP 5089	Subtype selective alpha1A antagonist	[157066-76-7]
A 61603 hydrobromide	alpha1A agonist	[107756-30-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADRA1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADRA1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033303

Sigma-Aldrich siRNA and siRNA Panels for ADRA1A

Sigma-Aldrich shRNA Panels and shRNA for ADRA1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000680 NM_033302 NM_033303 NM_033304

REFSEQ mRNAs for ADRA1A gene (4 alternative transcripts):

NM_000680.2 NM_033302.2 NM_033303.3 NM_033304.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000680 NM_033302 NM_033303 NM_033304

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000680
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000680
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000680

Additional cDNA sequence:

AF013261.1 AF395806.1 AK289548.1 AK311558.1 AY491775.1 AY491776.1 AY491777.1 AY491778.1

AY491781.1 BC095512.1 D25235.1 D32201.1 D32202.1 L31774.1 S76001.1 U02569.1

8 DOTS entries:

DT.456038 DT.95193429 DT.95193430 DT.99953072 DT.102825087 DT.87046229 DT.95261826 DT.97798254

24 AceView cDNA sequences:

D32201 AY491778 NM_033302 L31774 S76001 AA312801 D32202 NM_033304

AY491775 U02569 AF395806 AY491777 NM_000680 AA383171 NM_033303 AF013261

CF147810 D25235 AY491780 AY491776 AA345702 AY491781 AV654179 AW956748

highest scoring ESTs for ADRA1A:

D25235 D32202 AF013261 AF395806 AY491775 AY491776 AY491777 AY491778 CF147810 D32201

Unigene Cluster for ADRA1A:

Adrenergic, alpha-1A-, receptor

Hs.709175 [show with all ESTs]

Unigene Representative Sequence: AK289548

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5
SP1:					-				-		-
SP2:					-				-
SP3:					-		-		-		-
SP4:
SP5:					-

About this scheme

ECgene alternative splicing isoforms for ADRA1A

10 Ensembl transcripts including schematic representations:

ENST00000354550 ENST00000380573 ENST00000358857 ENST00000380582 ENST00000380572 ENST00000276393

ENST00000380581 ENST00000380586 ENST00000356368 ENST00000380587

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADRA1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADRA1A

¹ / ² / ³

10 probe-sets matching ADRA1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36715_at²^{, 3}	U95-A	1	1.00	1.00	0.32	0.37	D25235	1.00	1.00	1.00	1
36716_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D32202	1.00	1.00	1.00	1
211491_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D32202	1.00	1.00	1.00	1
211490_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF013261	0.80	1.00	0.91	1
211492_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U02569	0.80	1.00	0.91	1
211489_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D32201	0.80	1.00	0.91	1
211491_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211490_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211492_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211489_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGCAGTGCT

SOURCE GeneReport for Unigene cluster: Hs.709175
Expression variation in blood from EXPOLDB for ADRA1A
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
Tissue specificity: Heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and
pituitary. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also
detected in liver and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADRA1A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADRA1A¹	--	adrenergic, alpha-1A-, receptor	91.85(n) 92.92(a)	403866 XM_534567.2 XP_534567.2
cow (Bos taurus)	ADRA1A¹	--	adrenergic, alpha-1A-, receptor	90.2(n) 92.06(a)	282134 NM_174498.2 NP_776923.1
rat (Rattus norvegicus)	Adra1a¹	--	adrenergic, alpha-1A-, receptor	87.55(n) 92.27(a)	29412 NM_017191.1 NP_058887.1
mouse (Mus musculus)	Adra1a^{1, 5}	14⁵	adrenergic receptor, alpha 1a^{1, 5}	87.12(n)¹ 91.85(a)¹	11549¹ NM_013461.3¹ NP_038489.2¹ AF031431⁵ AF362076⁵ (see all 13)
chicken (Gallus gallus)	ADRA1A¹	--	adrenergic, alpha-1A-, receptor	73.75(n) 77.25(a)	428203 XM_425762.2 XP_425762.2

About this table Species with no ortholog for ADRA1A

ENSEMBL Gene Tree for ADRA1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADRA1A gene

ADRA1B² ADRA1D² HRH2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/942 NCBI SNPs in ADRA1A are shown (see all 942 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 327)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1048101^1,2	A,C,F,H,O	26683945(-)	`GTCTCC/TGCAGA`	4	C/R	mis¹ ese³		17	MN NA EU EA WA	1484
	rs12680215^1,2	A,C,F,H	26678944(+)	`GATACG/AGGGCA`	3	--	int¹ ng5¹		4	EU EA WA	418
	rs2229126^1,2	C,F,H	26683589(-)	`GAGGAA/TGTCTA`	4	E/D	mis¹ int¹ trp³		13	MN NA EU EA WA	1060
	rs11776470^1,2	C,F,H	26661410(+)	`TTCTTG/ACAGAT`	1	--	ng5¹		8	EU EA WA	836
	rs10503799^1,2	C,F,H	26661541(+)	`ACAGCG/AATTTA`	1	--	ng5¹		16	NS EU EA WA NA	1074
	rs3802241^1,2	C,F,H	26679301(+)	`AAATTA/GCCTGC`	3	--	int¹ ut3¹		7	NA EU EA WA	548
	rs17055965^1,2	C,F,H	26682996(+)	`CAGTCA/GAAGGT`	4	--	int¹ ng5¹		11	NA EU EA WA	980
	rs17333700^1,2	C,F,H	26679318(+)	`AAATAG/CTTCCT`	3	--	int¹ ut3¹		11	NA EU EA WA	980
	rs9314328^1,2	C,F,H	26661577(+)	`ACAACC/ATTTAT`	1	--	ng5¹		16	EU EA WA NS NA	1084
	rs3739216^1,2	C,F,H	26683166(+)	`CAGTAG/CGTTGA`	4	--	int¹ ut3¹ ese³		16	EA NA EU WA	2894

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HapMap Linkage Disequilibrium images for ADRA1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104219

2 Novoseek disease relationships for ADRA1A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
benign prostatic hyperplasia	56.42	4	10843225 (1), 11055359 (1), 16536786 (1), 8183249 (1)
attention-deficit hyperactivity disorder	26.68	1	11326305 (1)

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Human Gene Mutation Database: ADRA1A
Genetic Association Database: ADRA1A
Human Genome Epidemiology Navigator: ADRA1A (30 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/87 PubMed articles for ADRA1A gene (see all 87 ):

Alpha 1A-adrenergic receptor polymorphism and vascular response. (PubMed id 15179408)^{3, 4, 6} Sofowora G.G.... Stein C.M. (2004)
Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. (PubMed id 8832064)^{3, 4, 6} Shibata K....Tsujimoto G. (1996)
Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. (PubMed id 8396931)^{1, 3, 4} Hirasawa A....Tsujimoto G. (1993)
Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. (PubMed id 10493934)^{1, 3, 4} Coge F.... Canet E. (1999)
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)^{1, 3, 4} Forray C.... Gluchowski C. (1994)
Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PubMed id 16043131)^{1, 3, 6} Clark D.A....Kerwin R.W. (2005)
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)^{1, 3, 6} Matayoshi T....Kawano Y. (2004)
Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (PubMed id 12519093)^{1, 3, 6} Snapir A....Scheinin M. (2003)
Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects. (PubMed id 16153395)^{3, 6} Jiang S....Wang X. (2005)
A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. (PubMed id 15136785)^{3, 6} Klotsman M....Hartmann K.E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 148	HGNC: 277	AceView: ADRA1A	Ensembl:ENSG00000120907	euGenes: HUgn148
ECgene: ADRA1A	H-InvDB: ADRA1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ADRA1A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADRA1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADRA1A-related products

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for ADRA1A		Antibodies for ADRA1A
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (alpha 1c Adrenergic Receptor, alpha 1 Adrenergic Receptor)
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Antibodies for ADRA1A

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADRA1A Gene at Home site.
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ADRA1A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ADRA1A

Summaries
for ADRA1A

Genomic Location
for ADRA1A

Proteins
for ADRA1A

Protein Domains/
Families
for ADRA1A

Gene Function
for ADRA1A

Pathways & Interactions
for ADRA1A

Drugs & Compounds
for ADRA1A

Transcripts
for ADRA1A

Expression
for ADRA1A

Orthologs
for ADRA1A

Paralogs
for ADRA1A

SNPs/Variants
for ADRA1A

Disorders & Mutations
for ADRA1A

Medical News
for ADRA1A

Publications
for ADRA1A

Search for ADRA1A

Genome Databases showing ADRA1A

Other Databases showing ADRA1A

Specialized Databases showing ADRA1A

Licensable Technologies
for ADRA1A

Services
for ADRA1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADRA1A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ADRA1A

Summariesfor ADRA1A

Genomic Locationfor ADRA1A

Proteinsfor ADRA1A

Protein Domains/Familiesfor ADRA1A

Gene Functionfor ADRA1A

Pathways & Interactionsfor ADRA1A

Drugs & Compoundsfor ADRA1A

Transcriptsfor ADRA1A

Expression for ADRA1A

Orthologsfor ADRA1A

Paralogsfor ADRA1A

SNPs/Variantsfor ADRA1A

Disorders & Mutationsfor ADRA1A

Medical Newsfor ADRA1A

Publicationsfor ADRA1A

Search for ADRA1A

Genome Databases showing ADRA1A

Other Databases showing ADRA1A

Specialized Databases showing ADRA1A

Licensable Technologiesfor ADRA1A

Servicesfor ADRA1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADRA1A

Summaries
for ADRA1A

Genomic Location
for ADRA1A

Proteins
for ADRA1A

Protein Domains/
Families
for ADRA1A

Gene Function
for ADRA1A

Pathways & Interactions
for ADRA1A

Drugs & Compounds
for ADRA1A

Transcripts
for ADRA1A

Expression
for ADRA1A

Orthologs
for ADRA1A

Paralogs
for ADRA1A

SNPs/Variants
for ADRA1A

Disorders & Mutations
for ADRA1A

Medical News
for ADRA1A

Publications
for ADRA1A

Licensable Technologies
for ADRA1A

Services
for ADRA1A