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Aliases for ADPRM Gene

Aliases for ADPRM Gene

  • ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent 2 3 5
  • CDP-Choline Phosphohydrolase 3 4
  • ADPRibase-Mn 3 4
  • C17orf48 3 4
  • ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese-Dependent 2
  • Manganese-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase 3
  • ADP-Ribose/CDP-Alcohol Pyrophosphatase 3
  • Chromosome 17 Open Reading Frame 48 2
  • EC 3.6.1.13 4
  • EC 3.6.1.16 4
  • EC 3.6.1.53 4
  • NBLA03831 3
  • MDS006 3

External Ids for ADPRM Gene

Previous HGNC Symbols for ADPRM Gene

  • C17orf48

Summaries for ADPRM Gene

GeneCards Summary for ADPRM Gene

ADPRM (ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and CDP-glycerol diphosphatase activity.

UniProtKB/Swiss-Prot for ADPRM Gene

  • Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRM Gene

Genomics for ADPRM Gene

Regulatory Elements for ADPRM Gene

Enhancers for ADPRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F010695 0.9 ENCODE 43.9 +0.6 645 5.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 NFYC ADPRM MYH3 SCO1
GH17F010732 0.2 ENCODE 43.8 +36.2 36238 2.3 NRF1 ADPRM TMEM220 SCO1 MYH3 ENSG00000240813
GH17F010701 0.2 Ensembl 42.4 +4.9 4907 1.4 NR2F1 ZNF701 NR2F6 PRDM10 SPI1 ADPRM TMEM220 SCO1 PIR53353
GH17F010672 0.4 ENCODE 40.9 -23.3 -23289 3.1 ADPRM MYH3 ENSG00000261433
GH17F010723 0.7 ENCODE 39.6 +28.3 28281 4.0 CTCF ZNF146 MLX ZNF644 RAD21 RARA YY1 ZNF316 GATA3 ZNF143 ADPRM TMEM220 MYH3 TMEM220-AS1 MAGOH2P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADPRM on UCSC Golden Path with GeneCards custom track

Promoters for ADPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340906 106 3001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 NFYC

Genomic Location for ADPRM Gene

Chromosome:
17
Start:
10,697,594 bp from pter
End:
10,711,558 bp from pter
Size:
13,965 bases
Orientation:
Plus strand

Genomic View for ADPRM Gene

Genes around ADPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRM Gene

Proteins for ADPRM Gene

  • Protein details for ADPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LIE5-ADPRM_HUMAN
    Recommended name:
    Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Protein Accession:
    Q3LIE5
    Secondary Accessions:
    • A8K9B4
    • D3DTS4
    • Q9BVD4
    • Q9NRU8

    Protein attributes for ADPRM Gene

    Size:
    342 amino acids
    Molecular mass:
    39529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF87317.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ADPRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADPRM Gene

Post-translational modifications for ADPRM Gene

No Post-translational modifications

Other Protein References for ADPRM Gene

No data available for DME Specific Peptides for ADPRM Gene

Domains & Families for ADPRM Gene

Protein Domains for ADPRM Gene

Suggested Antigen Peptide Sequences for ADPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LIE5

UniProtKB/Swiss-Prot:

ADPRM_HUMAN :
  • Belongs to the ADPRibase-Mn family.
Family:
  • Belongs to the ADPRibase-Mn family.
genes like me logo Genes that share domains with ADPRM: view

No data available for Gene Families for ADPRM Gene

Function for ADPRM Gene

Molecular function for ADPRM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CDP-choline + H(2)O = CMP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Enzyme Numbers (IUBMB) for ADPRM Gene

Gene Ontology (GO) - Molecular Function for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047631 ADP-ribose diphosphatase activity TAS --
GO:0047734 CDP-glycerol diphosphatase activity IEA --
genes like me logo Genes that share ontologies with ADPRM: view
genes like me logo Genes that share phenotypes with ADPRM: view

Animal Model Products

miRNA for ADPRM Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADPRM Gene

Localization for ADPRM Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPRM Gene COMPARTMENTS Subcellular localization image for ADPRM gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADPRM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADPRM Gene

Pathways & Interactions for ADPRM Gene

genes like me logo Genes that share pathways with ADPRM: view

Pathways by source for ADPRM Gene

Interacting Proteins for ADPRM Gene

Gene Ontology (GO) - Biological Process for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ADPRM: view

No data available for SIGNOR curated interactions for ADPRM Gene

Drugs & Compounds for ADPRM Gene

(2) Drugs for ADPRM Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0

(7) Additional Compounds for ADPRM Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
CDP-glycerol
Citicoline
  • Audes
  • CDP-Choline
  • Cereb
  • Choline 5'-cytidine diphosphate
  • Choline cytidine diphosphate
987-78-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
genes like me logo Genes that share compounds with ADPRM: view

Transcripts for ADPRM Gene

Unigene Clusters for ADPRM Gene

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRM Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2: -
SP3:

Relevant External Links for ADPRM Gene

GeneLoc Exon Structure for
ADPRM
ECgene alternative splicing isoforms for
ADPRM

Expression for ADPRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADPRM Gene

Protein differential expression in normal tissues from HIPED for ADPRM Gene

This gene is overexpressed in Testis (32.7), CD8 Tcells (19.9), and Platelet (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADPRM Gene



Protein tissue co-expression partners for ADPRM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADPRM Gene:

ADPRM

SOURCE GeneReport for Unigene cluster for ADPRM Gene:

Hs.47668
genes like me logo Genes that share expression patterns with ADPRM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADPRM Gene

Orthologs for ADPRM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPRM 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia ADPRM 34 35
  • 87.14 (n)
cow
(Bos Taurus)
Mammalia ADPRM 34 35
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Adprm 34 16 35
  • 84.9 (n)
rat
(Rattus norvegicus)
Mammalia Adprm 34
  • 83.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ADPRM 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17ORF48 34
  • 65.01 (n)
lizard
(Anolis carolinensis)
Reptilia ADPRM 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adprm 34
  • 60.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia mds006-prov 34
zebrafish
(Danio rerio)
Actinopterygii adprm 34 35
  • 55.52 (n)
zgc64213 34
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24730 34
  • 49.61 (n)
rice
(Oryza sativa)
Liliopsida Os08g0557200 34
  • 49.94 (n)
Os.31656 34
Species where no ortholog for ADPRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRM Gene

ENSEMBL:
Gene Tree for ADPRM (if available)
TreeFam:
Gene Tree for ADPRM (if available)

Paralogs for ADPRM Gene

No data available for Paralogs for ADPRM Gene

Variants for ADPRM Gene

Sequence variations from dbSNP and Humsavar for ADPRM Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs587776629 Pathogenic 10,695,741(+) CTTAC(-/TC)TCTGC upstream-variant-2KB, reference, frameshift-variant
rs141606021 Likely benign 10,697,467(+) CCAGA(A/G)GCCGC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs142330047 Likely benign 10,695,763(+) TTGAC(A/G/T)TGCTT upstream-variant-2KB, reference, synonymous-codon, missense
rs61753148 Likely benign 10,697,492(+) TACTA(A/C/G)GACCA upstream-variant-2KB, reference, synonymous-codon, missense, utr-variant-5-prime
rs751482122 Likely benign 10,697,482(+) CTCGT(A/C/G)CGGGT upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ADPRM Gene

Variant ID Type Subtype PubMed ID
esv2675560 CNV deletion 23128226
esv3639941 CNV loss 21293372
esv3639942 CNV loss 21293372
nsv1058835 CNV loss 25217958
nsv1063900 CNV gain 25217958
nsv1065819 CNV gain 25217958
nsv833367 CNV loss 17160897

Variation tolerance for ADPRM Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.49; 88.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADPRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRM Gene

Disorders for ADPRM Gene

Relevant External Links for ADPRM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPRM

No disorders were found for ADPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADPRM Gene

Publications for ADPRM Gene

  1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. (PMID: 18352857) Canales J. … Costas M.J. (Biochem. J. 2008) 2 3 64
  2. Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+- Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase. (PMID: 25692488) Cabezas A. … Cameselle J.C. (PLoS ONE 2015) 3 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ADPRM Gene

Sources for ADPRM Gene

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