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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADPRM Gene

protein-coding   GIFtS: 40
GCID: GC17P010600

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent

(Previous name: chromosome 17 open reading frame 48 )
(Previous symbol: C17orf48)
 Explore 2 diseases affiliated with
ADPRM via our new
 Human Malady Compendium 
Biological research products
for ADPRM
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese-Dependent1 2     NBLA038312
C17orf481 2 3     ADP-Ribose/CDP-Alcohol Pyrophosphatase2
ADPRibase-Mn2 3     Manganese-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase2
CDP-Choline Phosphohydrolase2 3     EC 3.6.1.133
MDS0061     EC 3.6.1.163
Chromosome 17 Open Reading Frame 481     EC 3.6.1.533

External Ids:    HGNC: 309251   Entrez Gene: 569852   Ensembl: ENSG000001702227   UniProtKB: Q3LIE53   

Export aliases for ADPRM gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ADPRM_HUMAN, Q3LIE5
Function: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing
ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of
ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ADPRM
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADPRM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADPRM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ADPRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRM gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P010600:  view genomic region     (about GC identifiers)

Start:
10,600,911 bp from pter      End:
10,614,875 bp from pter
Size:
13,965 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADPRM_HUMAN, Q3LIE5 (See protein sequence)
Recommended Name: Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase  
Size: 342 amino acids; 39529 Da
Cofactor: Magnesium (By similarity)
Subunit: Monomer (By similarity)
Sequence caution: Sequence=AAF87317.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8K9B4 D3DTS4 Q9BVD4 Q9NRU8
Alternative splicing: 2 isoforms:  Q3LIE5-1   Q3LIE5-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADPRM: NX_Q3LIE5

ADPRM Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_064618.3  
ENSEMBL proteins: 
 ENSP00000369099   ENSP00000431622   ENSP00000463134  

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADPRM for domains           About GeneDecksing

1 InterPro domain/family:
 IPR004843 Metallo_PEstase_dom

Graphical View of Domain Structure for InterPro Entry Q3LIE5

ProtoNet protein and cluster: Q3LIE5

UniProtKB/Swiss-Prot: ADPRM_HUMAN, Q3LIE5
Similarity: Belongs to the ADPRibase-Mn family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: ADPRM_HUMAN, Q3LIE5
Function: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing
ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of
ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity)
Catalytic activity: CDP-choline + H(2)O = CMP + phosphocholine
Catalytic activity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
Catalytic activity: CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate

Enzyme Numbers (IUBMB): EC 3.6.1.161 EC 3.6.1.131 EC 3.6.1.531

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Inhib. RNA
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0046872metal ion binding IEA--
GO:0047631ADP-ribose diphosphatase activity IEA--
GO:0047734CDP-glycerol diphosphatase activity IEA--


ADPRM for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for ADPRM:
 Increased G2M DNA content 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Purine metabolism
Purine metabolism1.00
2Glycerophospholipid biosynthesis
Glycerophospholipid metabolism0.54

Pathway sources
See GeneCards unified pathways
Show all pathways



2         Kegg Pathways  (Kegg details for ADPRM):
    Purine metabolism
Glycerophospholipid metabolism


ADPRM for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADPRM

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for ADPRM (ENSP000003690994) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
AGPAT6ENSP000003801844STRING: ENSP00000380184
AGPAT9ENSP000002644094STRING: ENSP00000264409
GPAMENSP000002652764STRING: ENSP00000265276
GPAT2ENSP000003525474STRING: ENSP00000352547
GPD1ENSP000003011494STRING: ENSP00000301149
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADPRM
Search CenterWatch for drugs/clinical trials and news about ADPRM 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADPRM gene: 
NM_020233.4  

Unigene Cluster for ADPRM:

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
Hs.47668  [show with all ESTs]
Unigene Representative Sequence: NM_020233
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000379774(uc002gmt.3 uc010vvg.1) ENST00000468843(uc002gmu.3 uc002gmv.3)
ENST00000527582

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SwitchGear 3'UTR luciferase reporter plasmidADPRM 3' UTR sequence
Inhib. RNA
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Additional cDNA sequence: 

AB073393.1 AF168715.1 AK292629.1 

5 DOTS entries:

DT.102830571  DT.100751907  DT.411972  DT.120908282  DT.120908328 

24/84 AceView cDNA sequences (see all 84):

BG282949 BG026561 BM792421 W30757 AL527655 CR605738 CK826536 AA479340 
AW170606 BX110576 BI914385 BI819803 CR612920 AW770561 CD672249 W76468 
BQ924013 BM703528 BF984506 AA478606 BE612457 CB992449 BG503613 AI050090 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRM    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:                              
SP2:              -               
SP3:                              


ECgene alternative splicing isoforms for ADPRM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See ADPRM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADPRM

SOURCE GeneReport for Unigene cluster: Hs.47668
    SABiosciences Custom PCR Arrays for ADPRM
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADPRM gene from 7/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adprm1 , 5 RIKEN cDNA 2310004I24 gene5
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent1
84.96(n)1
85.25(a)1
  11 (40.59 cM)5
663581  NM_025510.31  NP_079786.21 
 670379055 
chicken
(Gallus gallus)
Aves C18H17orf481 chromosome 18 open reading frame, human C17orf48 65.81(n)
66.49(a)
  768578  XM_001231600.2  XP_001231601.2 
lizard
(Anolis carolinensis)
Reptilia C17orf486
--
56(a)
1 ↔ 1
2(108823636-108829955)
African clawed frog
(Xenopus laevis)
Amphibia mds006-prov2 x 006 protein 76.62(n)    BC056093.1 
zebrafish
(Danio rerio)
Actinopterygii zgc642132 hypothetical protein MGC64213 71.87(n)   393393  BC054642.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G247301 calcineurin-like phosphoesterase family protein 49.28(n)
40.47(a)
  828575  NM_001125573.1  NP_001119045.1 
rice
(Oryza sativa)
Liliopsida Os.316562 Oryza sativa (japonica cultivar-group) cDNA clone0 more 69.65(n)    AK069836.1 


ENSEMBL Gene Tree for ADPRM (if available)
TreeFam Gene Tree for ADPRM (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/240 NCBI SNPs in ADPRM are shown (see all 240    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs732876291,2
C,F,--10602967(+) CTCCCG/ATGTAG 1 -- int16Minor allele frequency- A:0.46WA NA CSA EA 248
rs1145092891,2
F,--10602992(+) GCGTGC/TCACCA 1 -- int11Minor allele frequency- T:0.02WA 118
rs1418132931,2
--10603064(+) TAGGAC/TGGTCT 1 -- int10--------
rs1912916441,2
--10603084(+) GACATC/GGTGAT 1 -- int10--------
rs1835967841,2
--10603100(+) CGCCTC/TGGCCT 1 -- int10--------
rs1461689241,2
--10603153(+) CCCAAC/TTTAGA 1 -- int10--------
rs25201621,2
C,F,H,--10603321(-) CAAAAA/TTGAAG 1 -- int16Minor allele frequency- T:0.09NS EA WA 540
rs25201611,2
C,F,A,H,--10603421(-) GCATAC/TGTTTT 1 -- int117Minor allele frequency- T:0.48NA EA WA CSA 876
rs25201601,2
C,F,A,H,--10603423(-) CAGCAT/AATGTT 1 -- int17Minor allele frequency- A:0.07NS EA WA 650
rs1389985621,2
--10603543(+) GAAATC/GATACT 1 -- int10--------

HapMap Linkage Disequilibrium report for ADPRM (10600911 - 10614875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ADPRM: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADPRM for disorders           About GeneDecksing

2 diseases for ADPRM:    About MalaCards
alcoholism    neuroblastoma


Export disorders for ADPRM gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ADPRM gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADPRM)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase : a novel metallophosphoesterase family preferentially expressed in rodent immu ne cells. (PubMed id 18352857)1, 3 Canales J....Costas M.J. (2008)
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 56985 HGNC: 30925 AceView: MDS006 Ensembl:ENSG00000170222 euGenes: HUgn56985
ECgene: ADPRM Kegg: 56985 H-InvDB: ADPRM

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ADPRM Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ADPRM gene:
Search GeneIP for patents involving ADPRM

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADPRM
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
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von Willebrand factor
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