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Aliases for ADPRM Gene

Aliases for ADPRM Gene

  • ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese-Dependent 2 3
  • CDP-Choline Phosphohydrolase 3 4
  • ADPRibase-Mn 3 4
  • C17orf48 3 4
  • Manganese-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase 3
  • ADP-Ribose/CDP-Alcohol Pyrophosphatase 3
  • Chromosome 17 Open Reading Frame 48 2
  • EC 3.6.1.13 4
  • EC 3.6.1.16 4
  • EC 3.6.1.53 4
  • NBLA03831 3
  • MDS006 3

External Ids for ADPRM Gene

Previous HGNC Symbols for ADPRM Gene

  • C17orf48

Summaries for ADPRM Gene

GeneCards Summary for ADPRM Gene

ADPRM (ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese-Dependent) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG) and Glycerophospholipid biosynthesis. GO annotations related to this gene include ADP-ribose diphosphatase activity and CDP-glycerol diphosphatase activity.

UniProtKB/Swiss-Prot for ADPRM Gene

  • Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRM Gene

Genomics for ADPRM Gene

Genomic Location for ADPRM Gene

Start:
10,697,594 bp from pter
End:
10,712,947 bp from pter
Size:
15,354 bases
Orientation:
Plus strand

Genomic View for ADPRM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRM Gene

No data available for Regulatory Elements for ADPRM Gene

Proteins for ADPRM Gene

  • Protein details for ADPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LIE5-ADPRM_HUMAN
    Recommended name:
    Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Protein Accession:
    Q3LIE5
    Secondary Accessions:
    • A8K9B4
    • D3DTS4
    • Q9BVD4
    • Q9NRU8

    Protein attributes for ADPRM Gene

    Size:
    342 amino acids
    Molecular mass:
    39529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF87317.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ADPRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADPRM Gene

Proteomics data for ADPRM Gene at MOPED

Post-translational modifications for ADPRM Gene

No Post-translational modifications

Other Protein References for ADPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADPRM Gene

Domains for ADPRM Gene

Protein Domains for ADPRM Gene

Graphical View of Domain Structure for InterPro Entry

Q3LIE5

UniProtKB/Swiss-Prot:

ADPRM_HUMAN :
  • Q3LIE5
Family:
  • Belongs to the ADPRibase-Mn family.
genes like me logo Genes that share domains with ADPRM: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ADPRM Gene

Function for ADPRM Gene

Molecular function for ADPRM Gene

UniProtKB/Swiss-Prot CatalyticActivity: CDP-choline + H(2)O = CMP + phosphocholine
UniProtKB/Swiss-Prot CatalyticActivity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
UniProtKB/Swiss-Prot CatalyticActivity: CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot Function: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Enzyme Numbers (IUBMB) for ADPRM Gene

Gene Ontology (GO) - Molecular Function for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
GO:0047631 ADP-ribose diphosphatase activity IEA --
GO:0047734 CDP-glycerol diphosphatase activity IEA --
genes like me logo Genes that share ontologies with ADPRM: view

Phenotypes for ADPRM Gene

GenomeRNAi human phenotypes for ADPRM:
genes like me logo Genes that share phenotypes with ADPRM: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPRM

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADPRM Gene

Localization for ADPRM Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADPRM Gene

Pathways for ADPRM Gene

genes like me logo Genes that share pathways with ADPRM: view

Pathways by source for ADPRM Gene

2 KEGG pathways for ADPRM Gene

Interacting Proteins for ADPRM Gene

Gene Ontology (GO) - Biological Process for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ADPRM: view

Transcripts for ADPRM Gene

Unigene Clusters for ADPRM Gene

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPRM

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRM Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2: -
SP3:

Relevant External Links for ADPRM Gene

GeneLoc Exon Structure for
ADPRM
ECgene alternative splicing isoforms for
ADPRM

Expression for ADPRM Gene

mRNA expression in normal human tissues for ADPRM Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADPRM Gene

SOURCE GeneReport for Unigene cluster for ADPRM Gene Hs.47668

genes like me logo Genes that share expressions with ADPRM: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADPRM Gene

Orthologs for ADPRM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADPRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPRM 35
  • 99.32 (n)
  • 98.54 (a)
ADPRM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADPRM 35
  • 86.65 (n)
  • 87.83 (a)
ADPRM 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPRM 35
  • 87.14 (n)
  • 89.32 (a)
ADPRM 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adprm 35
  • 84.9 (n)
  • 85 (a)
Adprm 16
Adprm 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADPRM 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adprm 35
  • 83.78 (n)
  • 86.05 (a)
chicken
(Gallus gallus)
Aves C17ORF48 35
  • 65.01 (n)
  • 65.17 (a)
lizard
(Anolis carolinensis)
Reptilia ADPRM 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mds006-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adprm 35
  • 60.64 (n)
  • 54.21 (a)
zebrafish
(Danio rerio)
Actinopterygii adprm 35
  • 55.52 (n)
  • 53.18 (a)
adprm 36
  • 52 (a)
OneToOne
zgc64213 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24730 35
  • 49.61 (n)
  • 40.8 (a)
rice
(Oryza sativa)
Liliopsida Os.31656 35
Os08g0557200 35
  • 49.94 (n)
  • 45.18 (a)
Species with no ortholog for ADPRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRM Gene

ENSEMBL:
Gene Tree for ADPRM (if available)
TreeFam:
Gene Tree for ADPRM (if available)

Paralogs for ADPRM Gene

No data available for Paralogs for ADPRM Gene

Variants for ADPRM Gene

Sequence variations from dbSNP and Humsavar for ADPRM Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs368141 -- 10,712,370(-) CCTGA(A/G)ATGGG utr-variant-3-prime, nc-transcript-variant
rs368437 -- 10,712,336(-) GCCCT(A/G)AATGT utr-variant-3-prime, nc-transcript-variant
rs369167 -- 10,712,152(-) GATTC(C/G/T)TCCTA utr-variant-3-prime, nc-transcript-variant
rs369399 -- 10,708,238(-) TTGGC(C/T)AGGCT intron-variant
rs379403 -- 10,711,550(-) GAGCA(A/G)AAATT utr-variant-3-prime, nc-transcript-variant

Relevant External Links for ADPRM Gene

HapMap Linkage Disequilibrium report
ADPRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADPRM Gene

Disorders for ADPRM Gene

No disorders were found for ADPRM Gene.

No data available for UniProtKB/Swiss-Prot for ADPRM Gene

Publications for ADPRM Gene

  1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. (PMID: 18352857) Canales J. … Costas M.J. (Biochem. J. 2008) 2 3
  2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 4

Products for ADPRM Gene

Sources for ADPRM Gene

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