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Aliases for ADPRM Gene

Aliases for ADPRM Gene

  • ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent 2 3
  • ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese-Dependent 2 3 5
  • CDP-Choline Phosphohydrolase 3 4
  • ADPRibase-Mn 3 4
  • C17orf48 3 4
  • ADP-Ribose/CDP-Alcohol Pyrophosphatase 3
  • Chromosome 17 Open Reading Frame 48 2
  • EC 3.6.1.13 4
  • EC 3.6.1.16 4
  • EC 3.6.1.53 4
  • NBLA03831 3
  • MDS006 3

External Ids for ADPRM Gene

Previous HGNC Symbols for ADPRM Gene

  • C17orf48

Summaries for ADPRM Gene

GeneCards Summary for ADPRM Gene

ADPRM (ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent) is a Protein Coding gene. Among its related pathways are Purine metabolism and Metabolism. GO annotations related to this gene include hydrolase activity and CDP-glycerol diphosphatase activity.

UniProtKB/Swiss-Prot for ADPRM Gene

  • Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRM Gene

Genomics for ADPRM Gene

Regulatory Elements for ADPRM Gene

Enhancers for ADPRM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADPRM on UCSC Golden Path with GeneCards custom track

Promoters for ADPRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADPRM on UCSC Golden Path with GeneCards custom track

Genomic Location for ADPRM Gene

Chromosome:
17
Start:
10,697,594 bp from pter
End:
10,711,558 bp from pter
Size:
13,965 bases
Orientation:
Plus strand

Genomic View for ADPRM Gene

Genes around ADPRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRM Gene

Proteins for ADPRM Gene

  • Protein details for ADPRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LIE5-ADPRM_HUMAN
    Recommended name:
    Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Protein Accession:
    Q3LIE5
    Secondary Accessions:
    • A8K9B4
    • D3DTS4
    • Q9BVD4
    • Q9NRU8

    Protein attributes for ADPRM Gene

    Size:
    342 amino acids
    Molecular mass:
    39529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF87317.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ADPRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADPRM Gene

Proteomics data for ADPRM Gene at MOPED

Post-translational modifications for ADPRM Gene

No Post-translational modifications

Other Protein References for ADPRM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADPRM Gene

Domains & Families for ADPRM Gene

Protein Domains for ADPRM Gene

Suggested Antigen Peptide Sequences for ADPRM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LIE5

UniProtKB/Swiss-Prot:

ADPRM_HUMAN :
  • Belongs to the ADPRibase-Mn family.
Family:
  • Belongs to the ADPRibase-Mn family.
genes like me logo Genes that share domains with ADPRM: view

No data available for Gene Families for ADPRM Gene

Function for ADPRM Gene

Molecular function for ADPRM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CDP-choline + H(2)O = CMP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).

Enzyme Numbers (IUBMB) for ADPRM Gene

Gene Ontology (GO) - Molecular Function for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047631 ADP-ribose diphosphatase activity TAS --
genes like me logo Genes that share ontologies with ADPRM: view
genes like me logo Genes that share phenotypes with ADPRM: view

Animal Model Products

miRNA for ADPRM Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADPRM Gene

Localization for ADPRM Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPRM Gene COMPARTMENTS Subcellular localization image for ADPRM gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADPRM Gene

Pathways & Interactions for ADPRM Gene

genes like me logo Genes that share pathways with ADPRM: view

Pathways by source for ADPRM Gene

Interacting Proteins for ADPRM Gene

Gene Ontology (GO) - Biological Process for ADPRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ADPRM: view

No data available for SIGNOR curated interactions for ADPRM Gene

Drugs & Compounds for ADPRM Gene

(2) Drugs for ADPRM Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Phosphocholine Experimental Pharma 0

(7) Additional Compounds for ADPRM Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
CDP-glycerol
Citicoline
  • Audes
  • CDP-Choline
  • Cereb
  • Choline 5'-cytidine diphosphate
  • Choline cytidine diphosphate
987-78-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
genes like me logo Genes that share compounds with ADPRM: view

Transcripts for ADPRM Gene

Unigene Clusters for ADPRM Gene

ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRM Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2: -
SP3:

Relevant External Links for ADPRM Gene

GeneLoc Exon Structure for
ADPRM
ECgene alternative splicing isoforms for
ADPRM

Expression for ADPRM Gene

mRNA expression in normal human tissues for ADPRM Gene

Protein differential expression in normal tissues from HIPED for ADPRM Gene

This gene is overexpressed in Testis (32.7), CD8 Tcells (19.9), and Platelet (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADPRM Gene



SOURCE GeneReport for Unigene cluster for ADPRM Gene Hs.47668

genes like me logo Genes that share expression patterns with ADPRM: view

Protein tissue co-expression partners for ADPRM Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADPRM Gene

Orthologs for ADPRM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADPRM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADPRM 35
  • 86.65 (n)
  • 87.83 (a)
ADPRM 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPRM 35
  • 87.14 (n)
  • 89.32 (a)
ADPRM 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adprm 35
  • 84.9 (n)
  • 85 (a)
Adprm 16
Adprm 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADPRM 35
  • 99.32 (n)
  • 98.54 (a)
ADPRM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adprm 35
  • 83.78 (n)
  • 86.05 (a)
oppossum
(Monodelphis domestica)
Mammalia ADPRM 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17ORF48 35
  • 65.01 (n)
  • 65.17 (a)
lizard
(Anolis carolinensis)
Reptilia ADPRM 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adprm 35
  • 60.64 (n)
  • 54.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia mds006-prov 35
zebrafish
(Danio rerio)
Actinopterygii adprm 35
  • 55.52 (n)
  • 53.18 (a)
zgc64213 35
adprm 36
  • 52 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24730 35
  • 49.61 (n)
  • 40.8 (a)
rice
(Oryza sativa)
Liliopsida Os.31656 35
Os08g0557200 35
  • 49.94 (n)
  • 45.18 (a)
Species with no ortholog for ADPRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRM Gene

ENSEMBL:
Gene Tree for ADPRM (if available)
TreeFam:
Gene Tree for ADPRM (if available)

Paralogs for ADPRM Gene

No data available for Paralogs for ADPRM Gene

Variants for ADPRM Gene

Sequence variations from dbSNP and Humsavar for ADPRM Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34940296 - 10,705,201(-) TAACA(A/C)GTTCT nc-transcript-variant, reference, missense
VAR_032126 -
rs427999 -- 10,709,536(-) CTTTC(C/T)AGTTT intron-variant
rs429303 -- 10,708,361(-) ACCTC(C/T)GCCTT intron-variant
rs430491 -- 10,707,799(-) TTCTA(A/T)ATGAA intron-variant

Variation tolerance for ADPRM Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.49; 88.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADPRM Gene

Disorders for ADPRM Gene

Relevant External Links for ADPRM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPRM

No disorders were found for ADPRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADPRM Gene

Publications for ADPRM Gene

  1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. (PMID: 18352857) Canales J. … Costas M.J. (Biochem. J. 2008) 2 3 67
  2. Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+- Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase. (PMID: 25692488) Cabezas A. … Cameselle J.C. (PLoS ONE 2015) 3
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ADPRM Gene

Sources for ADPRM Gene

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