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ADPRHL2 Gene

protein-coding   GIFtS: 58
GCID: GC01P036554

ADP-Ribosylhydrolase Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylhydrolase Like 21 2     EC 3.2.1.1433 8
ARH32 3 5     Poly(ADP-Ribose) Glycohydrolase ARH32
[Protein ADP-Ribosylarginine] Hydrolase-Like Protein 22 3     Protein ADP-Ribosylarginine Hydrolase-Like Protein 22
ADP-Ribosylhydrolase 32 3     

External Ids:    HGNC: 213041   Entrez Gene: 549362   Ensembl: ENSG000001168637   OMIM: 6106245   UniProtKB: Q9NX463   

Export aliases for ADPRHL2 gene to outside databases

Previous GC identifers: GC01P035981 GC01P035982 GC01P036223 GC01P036327 GC01P034671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADPRHL2 Gene:
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of
ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus
and cytoplasm.(provided by RefSeq, Feb 2009)

GeneCards Summary for ADPRHL2 Gene:
ADPRHL2 (ADP-ribosylhydrolase like 2) is a protein-coding gene. GO annotations related to this gene include poly(ADP-ribose) glycohydrolase activity.

UniProtKB/Swiss-Prot: ARHL2_HUMAN, Q9NX46
Function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by
poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal
function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze
ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG
mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria

Gene Wiki entry for ADPRHL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADPRHL2 gene promoter:
         HOXA9   HOXA9B   AREB6   HTF   ARP-1   Hand1   Meis-1a   Meis-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADPRHL2 promoter sequence
   Search Chromatin IP Primers for ADPRHL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADPRHL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

ADPRHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRHL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036554:  view genomic region     (about GC identifiers)

Start:
36,554,453 bp from pter      End:
36,559,533 bp from pter
Size:
5,081 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARHL2_HUMAN, Q9NX46 (See protein sequence)
Recommended Name: Poly(ADP-ribose) glycohydrolase ARH3 precursor  
Size: 363 amino acids; 38947 Da
Cofactor: Binds 2 magnesium ions per subunit
Subunit: Monomer (By similarity)
Sequence caution: Sequence=AAK14922.1; Type=Frameshift; Positions=Several;
3 PDB 3D structures from and Proteopedia for ADPRHL2:
2FOZ (3D)        2FP0 (3D)        2G4K (3D)    
Secondary accessions: Q53G94 Q6IAB8 Q9BY47

Explore the universe of human proteins at neXtProt for ADPRHL2: NX_Q9NX46

Explore proteomics data for ADPRHL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys146
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADPRHL2 (Q9NX46) (see all 7)
     YTDDTAM  GNGGAMR  SLGYNGA  ELGNGIAA 


    See ADPRHL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060295.1  
    ENSEMBL proteins: 
     ENSP00000362273  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005502 Ribosyl_crysJ1

    Graphical View of Domain Structure for InterPro Entry Q9NX46

    ProtoNet protein and cluster: Q9NX46

    1 Blocks protein domain: IPB005502 ADP-ribosylglycohydrolase

    UniProtKB/Swiss-Prot: ARHL2_HUMAN, Q9NX46
    Similarity: Belongs to the ADP-ribosylglycohydrolase family


    Find genes that share domains with ADPRHL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHL2_HUMAN, Q9NX46
    Function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by
    poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal
    function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze
    ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG
    mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria
    Catalytic activity: Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce
    free ADP-D-ribose
    Enzyme regulation: Activity is enhanced by magnesium

         Enzyme Number (IUBMB): EC 3.2.1.1431 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004649poly(ADP-ribose) glycohydrolase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ADPRHL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADPRHL2:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADPRHL2

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    miRTarBase miRNAs that target ADPRHL2:
    hsa-mir-10a-5p (MIRT047720), hsa-mir-1229-3p (MIRT036273), hsa-mir-130b-5p (MIRT038282)

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    hsa-miR-3128 hsa-miR-892b hsa-miR-133a hsa-miR-617 hsa-miR-1322 hsa-miR-133b hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidADPRHL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARHL2_HUMAN, Q9NX46: Cytoplasm. Mitochondrion matrix. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with ADPRHL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADPRHL2
    Interactions:

        Search GeneGlobe Interaction Network for ADPRHL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ADPRHL2 (Q9NX462, 3 ENSP000003622734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRA10AC1Q70Z532, 3, ENSP000003604884MINT-64739 I2D: score=4 STRING: ENSP00000360488
    HEXDCQ8WVB32, 3MINT-65045 I2D: score=5 
    OPCMLQ149823I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ADPRHL2 (ARHL2)

    2 HMDB Compounds for ADPRHL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADPRHL2 gene: 
    NM_017825.2  

    Unigene Cluster for ADPRHL2:

    ADP-ribosylhydrolase like 2
    Hs.18021  [show with all ESTs]
    Unigene Representative Sequence: AJ427295
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373178(uc001bzt.3)
    miRNA
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    hsa-miR-3128 hsa-miR-892b hsa-miR-133a hsa-miR-617 hsa-miR-1322 hsa-miR-133b hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidADPRHL2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ADPRHL2
      QuantiFast Probe-based Assays in human, mouse, rat ADPRHL2

    Additional mRNA sequence: 

    AF212236.1 AJ427295.1 AK000453.1 AK223037.1 AK295283.1 AK316349.1 BC014169.2 CR457237.1 

    10 DOTS entries:

    DT.116293  DT.100782024  DT.101981957  DT.100782036  DT.95201732  DT.100782033  DT.100799260  DT.121428859 
    DT.121428866  DT.97773038 

    Selected AceView cDNA sequences (see all 278):

    AI961718 CR595076 CR593151 W80653 BG697042 BE293057 CR611600 BM550782 
    BF685594 BE886818 CA313738 BP373152 AI802414 CF127823 BE384941 AL557348 
    CB996915 AI803413 BE895054 BI834255 BM468061 BG830130 AI421094 AJ427295 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                    -                                                   
    SP2:                    -     -                                             
    SP3:                    -     -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for ADPRHL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADPRHL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTTATTA
    ADPRHL2 Expression
    About this image


    ADPRHL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ADPRHL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADPRHL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18021

    UniProtKB/Swiss-Prot: ARHL2_HUMAN, Q9NX46
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADPRHL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adprhl21 , 5 ADP-ribosylhydrolase like 21, 5 87.76(n)1
    92.49(a)1
      4 (60.36 cM)5
    1002061  NM_133883.21  NP_598644.11 
     1263160475 
    chicken
    (Gallus gallus)
    Aves ADPRHL21 ADP-ribosylhydrolase like 2 70.29(n)
    70(a)
      419626  NM_001006312.1  NP_001006312.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADPRHL26
    ADP-ribosylhydrolase like 2
    66(a)
    1 ↔ 1
    GL343488.1(613115-618281)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.34942 Transcribed sequence with weak similarity to protein more 73.3(n)    AL857680.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36e062 Transcribed sequence with weak similarity to protein more 73.45(n)    57076760 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0025301 AgaP_AGAP002530 49.95(n)
    40.79(a)
      1273432  XM_312408.5  XP_312408.3 


    ENSEMBL Gene Tree for ADPRHL2 (if available)
    TreeFam Gene Tree for ADPRHL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADPRHL2 (see all 172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112638521,2
    C,A,H--36554442(+) GGAGCC/GCTGCG 1 -- us2k110Minor allele frequency- G:0.39MN EA NA WA 1620
    rs175514721,2
    C,F,H--36554449(+) TGCGGA/C/GCGGAA 1 -- us2k111MN EA NS 2648
    rs1999640841,2
    C--36554541(-) GCCCCC/TCCACC 2 G syn10--------
    rs1877768431,2
    --36554691(+) GACCCC/TGGCAC 2 P syn10--------
    rs2006757521,2
    --36554737(+) CGCAAG/TTCAGA 1 -- int10--------
    rs1910370691,2
    --36554837(+) GGCCAC/GAGCCG 1 -- int10--------
    rs1821147121,2
    --36554890(+) TCTCCA/GGCCTT 1 -- int10--------
    rs1880262771,2
    --36554973(+) ATAAAC/TCCATC 1 -- int10--------
    rs1437530581,2
    --36555090(+) GTTATC/TAGAAA 1 -- int10--------
    rs1136504651,2
    C,F--36555152(+) CCTTGC/TCGACT 1 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ADPRHL2 (36554453 - 36559533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADPRHL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871804CNV Loss21882294
    nsv834691CNV Loss17160897
    nsv871396CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610624    OMIM disorders: --


    Find genes that share disorders with ADPRHL2           About GenesLikeMe


    Export disorders for ADPRHL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADPRHL2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ADPRHL2)
        Utopia: connect your pdf to the dynamic
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    1. Identification and characterization of a mammalian 39-kDa poly(ADP- ribose) glycohydrolase. (PubMed id 16278211)1, 2, 3, 9 Oka S.... Moss J. (J. Biol. Chem. 2006)
    2. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PubMed id 12070318)1, 2, 3 Glowacki G.... Koch-Nolte F. (Protein Sci. 2002)
    3. The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. (PubMed id 17015823)1, 2, 9 Mueller-Dieckmann C.... Koch-Nolte F. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). (PubMed id 22433848)1, 2 Niere M.... Ziegler M. (J. Biol. Chem. 2012)
    5. Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. (PubMed id 17991898)1, 2 Niere M.... Ziegler M. (Mol. Cell. Biol. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54936 HGNC: 21304 AceView: ADPRHL2 Ensembl:ENSG00000116863 euGenes: HUgn54936
    ECgene: ADPRHL2 H-InvDB: ADPRHL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADPRHL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADPRHL2 gene:
    Search GeneIP for patents involving ADPRHL2

    GeneCards and IP:
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