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ADPRHL1 Gene

protein-coding   GIFtS: 47
GCID: GC13M114076

ADP-Ribosylhydrolase Like 1

  Search for ADPRHL1
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylhydrolase Like 11 2
ARH22 3 5
ADP-Ribosylhydrolase 22 3
ADP-ribosyl-hydrolase2
[Protein ADP-Ribosylarginine] Hydrolase-Like Protein 12
EC 3.2.-.-3

External Ids:    HGNC: 213031   Entrez Gene: 1136222   Ensembl: ENSG000001535317   OMIM: 6106205   UniProtKB: Q8NDY33   

Export aliases for ADPRHL1 gene to outside databases

Previous GC identifers: GC13M113162 GC13M112024 GC13M113124 GC13M094515


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADPRHL1 Gene:
ADP-ribosylation is a reversible posttranslational modification used to regulate protein function.
ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and
ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 (PubMed 12070318)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for ADPRHL1 Gene:
ADPRHL1 (ADP-ribosylhydrolase like 1) is a protein-coding gene. GO annotations related to this gene include ADP-ribosylarginine hydrolase activity and magnesium ion binding. An important paralog of this gene is ADPRH.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_027140.7  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADPRHL1 gene promoter:
         TBP   p53   AML1a   LUN-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADPRHL1 promoter sequence
   Search Chromatin IP Primers for ADPRHL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADPRHL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ADPRHL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRHL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114076:  view genomic region     (about GC identifiers)

Start:
114,076,260 bp from pter      End:
114,107,839 bp from pter
Size:
31,580 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARHL1_HUMAN, Q8NDY3 (See protein sequence)
Recommended Name: [Protein ADP-ribosylarginine] hydrolase-like protein 1  
Size: 354 amino acids; 40105 Da
Secondary accessions: Q5JUG2 Q96GD1
Alternative splicing: 2 isoforms:  Q8NDY3-1   Q8NDY3-2   

Explore the universe of human proteins at neXtProt for ADPRHL1: NX_Q8NDY3

Explore proteomics data for ADPRHL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADPRHL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_612439.2  NP_954631.1  

    ENSEMBL proteins: 
     ENSP00000348894   ENSP00000364567   ENSP00000416213  

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    Cloud-Clone Corp. CLIAs for ADPRHL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005502 Ribosyl_crysJ1
     IPR012108 ADP-ribosylarg_hydro

    Graphical View of Domain Structure for InterPro Entry Q8NDY3

    ProtoNet protein and cluster: Q8NDY3

    1 Blocks protein domain: IPB005502 ADP-ribosylglycohydrolase

    UniProtKB/Swiss-Prot: ARHL1_HUMAN, Q8NDY3
    Similarity: Belongs to the ADP-ribosylglycohydrolase family


    ADPRHL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 3.2.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003875ADP-ribosylarginine hydrolase activity IEA--
         
    ADPRHL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADPRHL1:
     Increased G1 DNA content  Increased cell number in G2M,  

    Animal Models:
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    4 qRT-PCR Assays for microRNAs that regulate ADPRHL1:
    hsa-miR-3163 hsa-miR-653 hsa-miR-377 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidADPRHL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ADPRHL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADPRHL1
    Interactions:

        Search GeneGlobe Interaction Network for ADPRHL1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051725protein de-ADP-ribosylation IEA--

    ADPRHL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADPRHL1 (ARHL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADPRHL1 gene (2 alternative transcripts): 
    NM_138430.4  NM_199162.2  

    Unigene Cluster for ADPRHL1:

    ADP-ribosylhydrolase like 1
    Hs.98669  [show with all ESTs]
    Unigene Representative Sequence: NM_199162
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356501(uc001vtp.1 uc001vtq.1) ENST00000375418 ENST00000413169

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ADPRHL1:
    hsa-miR-3163 hsa-miR-653 hsa-miR-377 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidADPRHL1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADPRHL1
    Primer
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    OriGene qPCR primer pairs and template standards for ADPRHL1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADPRHL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADPRHL1
      QuantiTect SYBR Green Assays in human, mouse, rat ADPRHL1
      QuantiFast Probe-based Assays in human, mouse, rat ADPRHL1

    Additional mRNA sequence: 

    AJ313429.1 BC009755.2 

    3 DOTS entries:

    DT.211314  DT.100021220  DT.101955660 

    Selected AceView cDNA sequences (see all 51):

    BQ063326 AA295521 AA463538 BC009755 BU632981 NM_199162 BM677225 NM_138430 
    BQ063299 BI869628 BQ064166 AJ313429 BQ066111 BU622510 BM722581 BM721616 
    CF147346 AI333260 BM914231 CA423997 BE250998 AA452429 CA424041 AA778467 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:        -     -                                                                                       
    SP2:                                                                                                      
    SP3:              -                                                                                       
    SP4:                                            -     -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ADPRHL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADPRHL1 expression in normal human tissues (normalized intensities)      ADPRHL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCATCTGG
    ADPRHL1 Expression
    About this image


    ADPRHL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Heart (Cardiovascular System)
     
     Bone (Muscoskeletal System)
     
     Skeletal Muscle (Muscoskeletal System)
    ADPRHL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADPRHL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98669
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADPRHL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adprhl11 , 5 ADP-ribosylhydrolase like 11, 5 79.98(n)1
    84.99(a)1
      8 (5.73 cM)5
    2340721  NM_172750.31  NP_766338.11 
     132356555 
    chicken
    (Gallus gallus)
    Aves ADPRHL16
    ADP-ribosylhydrolase like 1
    77(a)
    1 ↔ 1
    1(136753731-136773443)
    lizard
    (Anolis carolinensis)
    Reptilia ADPRHL16
    ADP-ribosylhydrolase like 1
    79(a)
    1 ↔ 1
    3(106152098-106193059)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24122 Xenopus laevis transcribed sequence with weak similarity more 75.54(n)    CB205952.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adprhl11 ADP-ribosylhydrolase like 1 67.43(n)
    68.86(a)
      450012  NM_001006033.1  NP_001006033.1 


    ENSEMBL Gene Tree for ADPRHL1 (if available)
    TreeFam Gene Tree for ADPRHL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADPRHL1 gene
    ADPRH2  
    1 SIMAP similar gene for ADPRHL1 using alignment to 1 protein entry:     ARHL1_HUMAN:
    ADPRH

    ADPRHL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADPRHL1 (see all 1250)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771750811,2
    F--114075844(+) GCAGGG/AGTCAT 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1125964281,2
    C,F--114075848(+) GGGTCG/ATTTCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1114503681,2
    C--114075908(+) GCTGGC/TCCGGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1866514861,2
    --114075928(+) CCCAAC/TGCACC 1 -- int10--------
    rs49076401,2
    C,F,A,H--114075931(+) AATGCG/ACCTGG 1 -- int115Minor allele frequency- A:0.10NS EA NA WA CSA 781
    rs1160190641,2
    C,F--114075933(+) TGCACC/TTGGGA 1 -- int11Minor allele frequency- T:0.12WA 118
    rs1453254471,2
    --114075949(+) GAGTCC/TGTGGC 1 -- int10--------
    rs1123539511,2
    C,F--114076022(+) AGCATT/AAAGAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1836931601,2
    --114076068(+) GAAGAC/TGCCCG 1 -- int10--------
    rs1861098551,2
    --114076071(+) GACGCA/CCGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ADPRHL1 (114076260 - 114107839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADPRHL1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677394CNV Deletion23128226
    esv2748295CNV Deletion23290073
    esv2748298CNV Deletion23290073
    esv1314688CNV Deletion17803354
    esv2748296CNV Deletion23290073
    nsv1195CNV Insertion18451855
    nsv509522CNV Insertion20534489
    esv2454485CNV Insertion19546169
    esv1482794CNV Insertion17803354
    nsv513403CNV Insertion21212237

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610620    OMIM disorders: --


    ADPRHL1 for disorders           About GeneDecksing


    Export disorders for ADPRHL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADPRHL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ADPRHL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PubMed id 12070318)1, 2, 3 Glowacki G.... Koch-Nolte F. (Protein Sci. 2002)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113622 HGNC: 21303 AceView: ADPRHL1 Ensembl:ENSG00000153531 euGenes: HUgn113622
    ECgene: ADPRHL1 H-InvDB: ADPRHL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADPRHL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADPRHL1 gene:
    Search GeneIP for patents involving ADPRHL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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