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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADPRHL1 Gene

protein-coding   GIFtS: 46
GCID: GC13M114076

ADP-Ribosylhydrolase Like 1

  Search for ADPRHL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylhydrolase Like 11 2
ARH22 3 5
ADP-Ribosylhydrolase 22 3
ADP-ribosyl-hydrolase2
[Protein ADP-Ribosylarginine] Hydrolase-Like Protein 12
EC 3.2.-.-3

External Ids:    HGNC: 213031   Entrez Gene: 1136222   Ensembl: ENSG000001535317   OMIM: 6106205   UniProtKB: Q8NDY33   

Export aliases for ADPRHL1 gene to outside databases

Previous GC identifers: GC13M113162 GC13M112024 GC13M113124 GC13M094515


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADPRHL1 Gene:
ADP-ribosylation is a reversible posttranslational modification used to regulate protein function.
ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and
ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 (PubMed 12070318)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for ADPRHL1 Gene: 
ADPRHL1 (ADP-ribosylhydrolase like 1) is a protein-coding gene. GO annotations related to this gene include ADP-ribosylarginine hydrolase activity and magnesium ion binding. An important paralog of this gene is ADPRH.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADPRHL1 gene promoter:
         TBP   p53   AML1a   LUN-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADPRHL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADPRHL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADPRHL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

ADPRHL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRHL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114076:  view genomic region     (about GC identifiers)

Start:
114,076,260 bp from pter      End:
114,107,839 bp from pter
Size:
31,580 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHL1_HUMAN, Q8NDY3 (See protein sequence)
Recommended Name: [Protein ADP-ribosylarginine] hydrolase-like protein 1  
Size: 354 amino acids; 40105 Da
Secondary accessions: Q5JUG2 Q96GD1
Alternative splicing: 2 isoforms:  Q8NDY3-1   Q8NDY3-2   

Explore the universe of human proteins at neXtProt for ADPRHL1: NX_Q8NDY3

Explore proteomics data for ADPRHL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NDY3

  • ADPRHL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADPRHL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_612439.2  NP_954631.1  

    ENSEMBL proteins: 
     ENSP00000348894   ENSP00000364567   ENSP00000416213  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012108 ADP-ribosylarg_hydro
     IPR005502 Ribosyl_crysJ1

    Graphical View of Domain Structure for InterPro Entry Q8NDY3

    ProtoNet protein and cluster: Q8NDY3

    1 Blocks protein domain: IPB005502 ADP-ribosylglycohydrolase

    UniProtKB/Swiss-Prot: ARHL1_HUMAN, Q8NDY3
    Similarity: Belongs to the ADP-ribosylglycohydrolase family


    ADPRHL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 3.2.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003875ADP-ribosylarginine hydrolase activity IEA--
         
    ADPRHL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADPRHL1:
     Increased G1 DNA content  Increased cell number in G2M,  

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADPRHL1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051725protein de-ADP-ribosylation IEA--

    ADPRHL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADPRHL1 (ARHL1)

    Search CenterWatch for drugs/clinical trials and news about ADPRHL1 / ARHL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADPRHL1 gene (2 alternative transcripts): 
    NM_138430.3  NM_199162.1  

    Unigene Cluster for ADPRHL1:

    ADP-ribosylhydrolase like 1
    Hs.98669  [show with all ESTs]
    Unigene Representative Sequence: NM_199162
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356501(uc001vtp.1 uc001vtq.1) ENST00000375418 ENST00000413169

    miRNA
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    hsa-miR-3163 hsa-miR-653 hsa-miR-377 hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidADPRHL1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADPRHL1
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    Additional mRNA sequence: 

    AJ313429.1 BC009755.2 

    3 DOTS entries:

    DT.211314  DT.100021220  DT.101955660 

    24/51 AceView cDNA sequences (see all 51):

    BC009755 BI869628 BM722581 NM_199162 BU622510 AA463538 NM_138430 BQ063299 
    BU632981 BQ064166 AJ313429 BQ066111 BM677225 AA295521 BQ063326 AI243209 
    AA778467 AA452429 BE744166 BE250998 CF147346 AI333260 AW118772 F34966 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:        -     -                                                                                       
    SP2:                                                                                                      
    SP3:              -                                                                                       
    SP4:                                            -     -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ADPRHL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADPRHL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCATCTGG
    ADPRHL1 Expression
    About this image


    See ADPRHL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADPRHL1

    SOURCE GeneReport for Unigene cluster: Hs.98669
        SABiosciences Custom PCR Arrays for ADPRHL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRHL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADPRHL1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adprhl11 , 5 ADP-ribosylhydrolase like 11, 5 79.98(n)1
    84.99(a)1
      8 (5.73 cM)5
    2340721  NM_172750.31  NP_766338.11 
     132356555 
    chicken
    (Gallus gallus)
    Aves ADPRHL11 ADP-ribosylhydrolase like 1 75.42(n)
    77.4(a)
      418741  XM_416940.2  XP_416940.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADPRHL16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    3(106152098-106193059)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24122 Xenopus laevis transcribed sequence with weak similarity more 75.54(n)    CB205952.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adprhl11 ADP-ribosylhydrolase like 1 67.43(n)
    68.86(a)
      450012  NM_001006033.1  NP_001006033.1 


    ENSEMBL Gene Tree for ADPRHL1 (if available)
    TreeFam Gene Tree for ADPRHL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADPRHL1 gene
    ADPRH2  
    1 SIMAP similar gene for ADPRHL1 using alignment to 1 protein entry:     ARHL1_HUMAN:
    ADPRH

    ADPRHL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1250 SNPs in ADPRHL1 are shown (see all 1250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771750811,2
    F--114075844(+) GCAGGG/AGTCAT 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1125964281,2
    C,F--114075848(+) GGGTCG/ATTTCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1114503681,2
    C--114075908(+) GCTGGC/TCCGGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1866514861,2
    --114075928(+) CCCAAC/TGCACC 1 -- int10--------
    rs49076401,2
    C,F,A,H--114075931(+) AATGCG/ACCTGG 1 -- int115Minor allele frequency- A:0.10NS EA NA WA CSA 781
    rs1160190641,2
    C,F--114075933(+) TGCACC/TTGGGA 1 -- int11Minor allele frequency- T:0.12WA 118
    rs1453254471,2
    --114075949(+) GAGTCC/TGTGGC 1 -- int10--------
    rs1123539511,2
    C,F--114076022(+) AGCATT/AAAGAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1836931601,2
    --114076068(+) GAAGAC/TGCCCG 1 -- int10--------
    rs1861098551,2
    --114076071(+) GACGCA/CCGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ADPRHL1 (114076260 - 114107839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ADPRHL1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677394CNV Deletion23128226
    esv2748295CNV Deletion23290073
    esv2748298CNV Deletion23290073
    esv1314688CNV Deletion17803354
    esv2748296CNV Deletion23290073
    nsv1195CNV Insertion18451855
    nsv509522CNV Insertion20534489
    esv2454485CNV Insertion19546169
    esv1482794CNV Insertion17803354
    nsv513403CNV Insertion21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADPRHL1 for disorders           About MalaCards
    OMIM gene information: 610620    OMIM disorders: --


    ADPRHL1 for disorders           About GeneDecksing


    Export disorders for ADPRHL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADPRHL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADPRHL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PubMed id 12070318)1, 2, 3 Glowacki G....Koch-Nolte F. (2002)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113622 HGNC: 21303 AceView: ADPRHL1 Ensembl:ENSG00000153531 euGenes: HUgn113622
    ECgene: ADPRHL1 H-InvDB: ADPRHL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADPRHL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADPRHL1 gene:
    Search GeneIP for patents involving ADPRHL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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