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Aliases for ADPRHL1 Gene

Aliases for ADPRHL1 Gene

  • ADP-Ribosylhydrolase Like 1 2 3
  • ARH2 3 4 6
  • ADP-Ribosylhydrolase 2 3 4
  • [Protein ADP-Ribosylarginine] Hydrolase-Like Protein 1 3
  • ADP-Ribosyl-Hydrolase 3
  • EC 3.2.-.- 4

External Ids for ADPRHL1 Gene

Summaries for ADPRHL1 Gene

Entrez Gene Summary for ADPRHL1 Gene

  • ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADPRHL1 Gene

ADPRHL1 (ADP-Ribosylhydrolase Like 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRH.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRHL1 Gene

Genomics for ADPRHL1 Gene

Genomic Location for ADPRHL1 Gene

Start:
113,421,940 bp from pter
End:
113,453,631 bp from pter
Size:
31,692 bases
Orientation:
Minus strand

Genomic View for ADPRHL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADPRHL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRHL1 Gene

Regulatory Elements for ADPRHL1 Gene

Transcription factor binding sites by QIAGEN in the ADPRHL1 gene promoter:

Proteins for ADPRHL1 Gene

  • Protein details for ADPRHL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDY3-ARHL1_HUMAN
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase-like protein 1
    Protein Accession:
    Q8NDY3
    Secondary Accessions:
    • Q5JUG2
    • Q96GD1

    Protein attributes for ADPRHL1 Gene

    Size:
    354 amino acids
    Molecular mass:
    40105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADPRHL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADPRHL1 Gene

Proteomics data for ADPRHL1 Gene at MOPED

Post-translational modifications for ADPRHL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADPRHL1 Gene

No data available for DME Specific Peptides for ADPRHL1 Gene

Domains for ADPRHL1 Gene

Protein Domains for ADPRHL1 Gene

UniProtKB/Swiss-Prot:

ARHL1_HUMAN
Family:
  • Belongs to the ADP-ribosylglycohydrolase family.:
    • Q8NDY3
genes like me logo Genes that share domains with ADPRHL1: view

No data available for Gene Families for ADPRHL1 Gene

Function for ADPRHL1 Gene

Enzyme Numbers (IUBMB) for ADPRHL1 Gene

Gene Ontology (GO) - Molecular Function for ADPRHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003875 ADP-ribosylarginine hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADPRHL1: view

Phenotypes for ADPRHL1 Gene

GenomeRNAi human phenotypes for ADPRHL1:
genes like me logo Genes that share phenotypes with ADPRHL1: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADPRHL1 Gene

Localization for ADPRHL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPRHL1 Gene COMPARTMENTS Subcellular localization image for ADPRHL1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADPRHL1 Gene

Pathways for ADPRHL1 Gene

SuperPathways for ADPRHL1 Gene

No Data Available

Interacting Proteins for ADPRHL1 Gene

Gene Ontology (GO) - Biological Process for ADPRHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051725 protein de-ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ADPRHL1: view

No data available for Pathways by source for ADPRHL1 Gene

Transcripts for ADPRHL1 Gene

mRNA/cDNA for ADPRHL1 Gene

Unigene Clusters for ADPRHL1 Gene

ADP-ribosylhydrolase like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRHL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2:
SP3: -
SP4: - -
SP5:

Relevant External Links for ADPRHL1 Gene

GeneLoc Exon Structure for
ADPRHL1
ECgene alternative splicing isoforms for
ADPRHL1

Expression for ADPRHL1 Gene

mRNA expression in normal human tissues for ADPRHL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADPRHL1 Gene

This gene is overexpressed in Heart - Left Ventricle (20.4), Heart - Atrial Appendage (12.1), and Muscle - Skeletal (11.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADPRHL1 Gene

SOURCE GeneReport for Unigene cluster for ADPRHL1 Gene Hs.98669

genes like me logo Genes that share expressions with ADPRHL1: view

Orthologs for ADPRHL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRHL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPRHL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADPRHL1 36
  • 78.81 (n)
  • 79.38 (a)
ADPRHL1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPRHL1 36
  • 81.16 (n)
  • 81.25 (a)
ADPRHL1 37
  • 17 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adprhl1 36
  • 79.98 (n)
  • 84.99 (a)
Adprhl1 16
Adprhl1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADPRHL1 37
  • 17 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPRHL1 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adprhl1 36
  • 80.64 (n)
  • 84.7 (a)
chicken
(Gallus gallus)
Aves ADPRHL1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPRHL1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2412 36
zebrafish
(Danio rerio)
Actinopterygii adprhl1 36
  • 67.43 (n)
  • 68.86 (a)
adprhl1 37
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for ADPRHL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRHL1 Gene

ENSEMBL:
Gene Tree for ADPRHL1 (if available)
TreeFam:
Gene Tree for ADPRHL1 (if available)

Paralogs for ADPRHL1 Gene

Paralogs for ADPRHL1 Gene

Selected SIMAP similar genes for ADPRHL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADPRHL1: view

Variants for ADPRHL1 Gene

Sequence variations from dbSNP and Humsavar for ADPRHL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3814256 -- 113,444,388(-) CCACC(C/G)TGCTG intron-variant
rs3814257 -- 113,444,222(-) GGGCC(C/G)CTCCT intron-variant
rs3892381 -- 113,426,561(+) GACCA(G/T)GACCT intron-variant
rs3892382 -- 113,426,578(+) GGCTC(A/G)CAGGC intron-variant
rs4340208 -- 113,445,936(+) CACGC(A/G)CGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADPRHL1 Gene

Variant ID Type Subtype PubMed ID
nsv901049 CNV Loss 21882294
dgv1802n71 CNV Loss 21882294
nsv901072 CNV Loss 21882294
dgv597e1 CNV Complex 17122850
nsv1195 CNV Insertion 18451855
nsv509522 CNV Insertion 20534489
nsv513403 CNV Insertion 21212237
esv2454485 CNV Insertion 19546169
esv1482794 CNV Insertion 17803354
esv2677394 CNV Deletion 23128226
nsv9116 CNV Gain 18304495
esv22722 CNV Gain+Loss 19812545
nsv64762 CNV Loss 16902084
esv2748295 CNV Deletion 23290073
nsv64447 CNV Loss 16902084
esv2748296 CNV Deletion 23290073
esv1314688 CNV Deletion 17803354
esv2748298 CNV Deletion 23290073
nsv901074 CNV Loss 21882294
nsv64502 CNV Loss 16902084
nsv456137 CNV Loss 19166990

Relevant External Links for ADPRHL1 Gene

HapMap Linkage Disequilibrium report
ADPRHL1

Disorders for ADPRHL1 Gene

No disorders were found for ADPRHL1 Gene.

No data available for UniProtKB/Swiss-Prot for ADPRHL1 Gene

Publications for ADPRHL1 Gene

  1. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 2 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ADPRHL1 Gene

Sources for ADPRHL1 Gene

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