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Aliases for ADPRH Gene

Aliases for ADPRH Gene

  • ADP-Ribosylarginine Hydrolase 2 3 4
  • ADP-Ribose-L-Arginine Cleaving Enzyme 3 4
  • EC 4 63
  • ARH1 3 4
  • [Protein ADP-Ribosylarginine] Hydrolase 3

External Ids for ADPRH Gene

Previous GeneCards Identifiers for ADPRH Gene

  • GC03P115940
  • GC03P118926
  • GC03P120579
  • GC03P120619
  • GC03P120781
  • GC03P119298
  • GC03P116674

Summaries for ADPRH Gene

Entrez Gene Summary for ADPRH Gene

  • The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ADPRH Gene

ADPRH (ADP-Ribosylarginine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRH include glycine n-methyltransferase deficiency and stuttering. GO annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot for ADPRH Gene

  • Catalyzes the reverse reaction of mono-ADP-ribosylation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRH Gene

Genomics for ADPRH Gene

Regulatory Elements for ADPRH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADPRH Gene

119,579,268 bp from pter
119,589,945 bp from pter
10,678 bases
Plus strand

Genomic View for ADPRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRH Gene

Proteins for ADPRH Gene

  • Protein details for ADPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
    Protein Accession:
    Secondary Accessions:
    • B2R8H1
    • D3DN83

    Protein attributes for ADPRH Gene

    357 amino acids
    Molecular mass:
    39507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADPRH Gene

neXtProt entry for ADPRH Gene

Proteomics data for ADPRH Gene at MOPED

Selected DME Specific Peptides for ADPRH Gene

Post-translational modifications for ADPRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADPRH Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ADPRH

Domains for ADPRH Gene

Protein Domains for ADPRH Gene

Suggested Antigen Peptide Sequences for ADPRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADP-ribosylglycohydrolase family.
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRH: view

No data available for Gene Families for ADPRH Gene

Function for ADPRH Gene

Molecular function for ADPRH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine
UniProtKB/Swiss-Prot CatalyticActivity:
N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine
UniProtKB/Swiss-Prot Function:
Catalyzes the reverse reaction of mono-ADP-ribosylation

Enzyme Numbers (IUBMB) for ADPRH Gene

Gene Ontology (GO) - Molecular Function for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003875 ADP-ribosylarginine hydrolase activity IMP 8349667
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ADPRH: view

Phenotypes for ADPRH Gene

MGI mutant phenotypes for ADPRH:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ADPRH: view

Animal Models for ADPRH Gene

MGI Knock Outs for ADPRH:

Animal Model Products

CRISPR Products

miRNA for ADPRH Gene

miRTarBase miRNAs that target ADPRH

No data available for Transcription Factor Targets and HOMER Transcription for ADPRH Gene

Localization for ADPRH Gene

Subcellular locations from

Jensen Localization Image for ADPRH Gene COMPARTMENTS Subcellular localization image for ADPRH gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADPRH Gene

Pathways for ADPRH Gene

SuperPathways for ADPRH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IMP 8349667
GO:0051725 protein de-ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Pathways by source for ADPRH Gene

Drugs for ADPRH Gene

(5) HMDB Compounds for ADPRH Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
  • Adenosindiphosphorsaeure
  • N(Omega)-(ADP-D-ribosyl)-arginine
  • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate
  • Dihydrogen oxide

(110) Novoseek inferred chemical compound relationships for ADPRH Gene

Compound -log(P) Hits PubMed IDs
adp-ribosylarginine 85.9 16
s-adenosylhomocysteine 85.1 62
paraoxon 82.8 14
carbocyclic 3-deazaadenosine 77.3 3
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid 76.3 3
genes like me logo Genes that share compounds with ADPRH: view

Transcripts for ADPRH Gene

Unigene Clusters for ADPRH Gene

ADP-ribosylarginine hydrolase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPRH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for ADPRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADPRH Gene

mRNA expression in normal human tissues for ADPRH Gene

Protein differential expression in normal tissues for ADPRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Spleen (8.7), and Lymph node (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADPRH Gene

SOURCE GeneReport for Unigene cluster for ADPRH Gene Hs.99884

genes like me logo Genes that share expressions with ADPRH: view

Expression partners for ADPRH Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADPRH Gene

Orthologs for ADPRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADPRH 35
  • 87.9 (n)
  • 88.76 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ADPRH 35
  • 88.7 (n)
  • 88.8 (a)
  • 88 (a)
(Mus musculus)
Mammalia Adprh 35
  • 82.35 (n)
  • 82.54 (a)
Adprh 16
Adprh 36
  • 81 (a)
(Pan troglodytes)
Mammalia ADPRH 35
  • 99.35 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Adprh 35
  • 82.25 (n)
  • 83.1 (a)
(Monodelphis domestica)
Mammalia ADPRH 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia ADPRH 36
  • 79 (a)
(Gallus gallus)
Aves ADPRH 35
  • 68.11 (n)
  • 67.72 (a)
  • 41 (a)
(Anolis carolinensis)
Reptilia ADPRH 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adprh 35
  • 67.63 (n)
  • 68.01 (a)
Str.9616 35
(Danio rerio)
Actinopterygii adprh 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for ADPRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRH Gene

Gene Tree for ADPRH (if available)
Gene Tree for ADPRH (if available)

Paralogs for ADPRH Gene

Paralogs for ADPRH Gene

(1) SIMAP similar genes for ADPRH Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADPRH: view

Variants for ADPRH Gene

Sequence variations from dbSNP and Humsavar for ADPRH Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs183536321 -- 119,578,756(+) GTACA(C/T)GTAAA upstream-variant-2KB
rs183482773 -- 119,581,709(+) AAGTG(C/T)AAAGC intron-variant
rs183421505 -- 119,580,269(+) GGCCA(A/C)GAAGC intron-variant
rs182655831 -- 119,585,141(+) CAAGG(A/G)TTGGC intron-variant
rs182393205 -- 119,589,306(+) CCCTC(A/C)GTCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADPRH Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
nsv3963 CNV Loss 18451855
nsv522542 CNV Loss 19592680

Relevant External Links for ADPRH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRH Gene

Disorders for ADPRH Gene

(32) Novoseek inferred disease relationships for ADPRH Gene

Disease -log(P) Hits PubMed IDs
i-cell disease 66.8 1
sphingolipidoses 63.8 1
lysosomal storage diseases 46 1
gaucher disease 30.3 2
tyrosinemias 26.1 1
genes like me logo Genes that share disorders with ADPRH: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for ADPRH Gene

Publications for ADPRH Gene

  1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PMID: 8349667) Takada T. … Moss J. (J. Biol. Chem. 1993) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 2 3
  4. The alpha 7 integrin as a target protein for cell surface mono-ADP-ribosylation in muscle cells. (PMID: 9193669) Zolkiewska A. … Moss J. (Adv. Exp. Med. Biol. 1997) 3
  5. Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. (PMID: 20400948) PAcrez-Dorado I. … Hermoso J.A. (Nat. Struct. Mol. Biol. 2010) 23

Products for ADPRH Gene

Sources for ADPRH Gene

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