Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADPRH Gene

protein-coding   GIFtS: 55
GCID: GC03P119298

ADP-Ribosylarginine Hydrolase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylarginine Hydrolase1 2 3
ARH12 3
ADP-Ribose-L-Arginine Cleaving Enzyme2 3
EC 3.2.2.193 8
[Protein ADP-Ribosylarginine] Hydrolase2

External Ids:    HGNC: 2691   Entrez Gene: 1412   Ensembl: ENSG000001448437   OMIM: 6030815   UniProtKB: P549223   

Export aliases for ADPRH gene to outside databases

Previous GC identifers: GC03P115940 GC03P118926 GC03P120579 GC03P120619 GC03P120781 GC03P116674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADPRH Gene:
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the
ADP-ribosylation cycle. Unlike the rat and mouse enzymes, which require DTT for maximal activity, the human
enzyme is DTT-independent. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADPRH Gene: 
ADPRH (ADP-ribosylarginine hydrolase) is a protein-coding gene. Diseases associated with ADPRH include glycine n-methyltransferase deficiency, and mucolipidosis ii. GO annotations related to this gene include ADP-ribosylarginine hydrolase activity and magnesium ion binding. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922
Function: Catalyzes the reverse reaction of mono-ADP-ribosylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADPRH gene promoter:
         HEN1   STAT1   AP-1   Zic1   ATF-2   c-Myb   c-Jun   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADPRH promoter sequence
   Search SABiosciences Chromatin IP Primers for ADPRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADPRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.31-q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.31-q13.33

ADPRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P119298:  view genomic region     (about GC identifiers)

Start:
119,298,115 bp from pter      End:
119,308,792 bp from pter
Size:
10,678 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922 (See protein sequence)
Recommended Name: [Protein ADP-ribosylarginine] hydrolase  
Size: 357 amino acids; 39507 Da
1 PDB 3D structure from and Proteopedia for ADPRH:
3HFW (3D)    
Secondary accessions: B2R8H1 D3DN83

Explore the universe of human proteins at neXtProt for ADPRH: NX_P54922

Explore proteomics data for ADPRH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54922

  • 4 DME Specific Peptides for ADPRH (P54922)
     WRVSDDT  VKERDQFY  IAGCWWGVM  SGWGGSSGHD 

    ADPRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADPRH Protein Expression
    REFSEQ proteins: NP_001116.1  
    ENSEMBL proteins: 
     ENSP00000420200   ENSP00000419703   ENSP00000417528   ENSP00000349496   ENSP00000417430  

    Human Recombinant Protein Products for ADPRH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ADPRH
    OriGene Purified Protein for ADPRH
    OriGene Protein Over-expression Lysate for ADPRH
    OriGene MassSpec for ADPRH 
    OriGene Custom Protein Services for ADPRH
    GenScript Custom Purified and Recombinant Proteins Services for ADPRH
    Novus Biologicals ADPRH Proteins
    Novus Biologicals ADPRH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ADPRH
    Cloud-Clone Corp. Proteins for ADPRH 


    ADPRH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADPRH
    GenScript Custom Superior Antibodies Services for ADPRH
    Novus Biologicals ADPRH Antibody
    Abcam antibodies for ADPRH
    Cloud-Clone Corp. Antibodies for ADPRH 
    Search ThermoFisher Antibodies for ADPRH
    LSBio Antibodies in human, mouse, rat for ADPRH 

    Assay Products for ADPRH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADPRH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADPRH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADPRH 
    Cloud-Clone Corp. CLIAs for ADPRH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012108 ADP-ribosylarg_hydro
     IPR005502 Ribosyl_crysJ1

    Graphical View of Domain Structure for InterPro Entry P54922

    ProtoNet protein and cluster: P54922

    1 Blocks protein domain: IPB005502 ADP-ribosylglycohydrolase

    UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922
    Similarity: Belongs to the ADP-ribosylglycohydrolase family


    ADPRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADPRH_HUMAN, P54922
    Function: Catalyzes the reverse reaction of mono-ADP-ribosylation
    Catalytic activity: Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine
    Catalytic activity: N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine

         Enzyme Number (IUBMB): EC 3.2.2.191 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003875ADP-ribosylarginine hydrolase activity IMP8349667
         
    ADPRH for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adprh):
     immune system 

    ADPRH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adprhtm1Jlms for ADPRH

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADPRH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADPRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADPRH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADPRH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADPRH
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADPRH (see all 10):
    hsa-miR-550a hsa-miR-516b hsa-miR-767-3p hsa-miR-624 hsa-miR-373* hsa-miR-3150b-3p hsa-miR-130b* hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidADPRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADPRH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADPRH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADPRH
    Sirion Biotech Customized adenovirus for overexpression of ADPRH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADPRH (see all 8)
    OriGene ORF clones in mouse, rat for ADPRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADPRH (NM_001125)
    Sino Biological Human cDNA Clone for ADPRH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADPRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADPRH
    Sirion Biotech Customized lentivirus for stable overexpression of ADPRH 
                         Customized lentivirus expression plasmids for stable overexpression of ADPRH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADPRH
    Search LifeMap BioReagents cell lines for ADPRH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADPRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for ADPRH (P549222, 3 ENSP000003494964) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H1AQ025392, 3, ENSP000002445734MINT-7288424 I2D: score=1 STRING: ENSP00000244573
    CREMENSP000002653724STRING: ENSP00000265372
    ENSG00000225164ENSP000004094444STRING: ENSP00000409444
    IFRD2ENSP000003989714STRING: ENSP00000398971
    PARD3ENSP000003639214STRING: ENSP00000363921
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IMP8349667
    GO:0051725protein de-ADP-ribosylation IEA--

    ADPRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADPRH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADPRH

    5 HMDB Compounds for ADPRH    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    ADP-Ribosyl-L-arginineN2-(ADP-D-ribosyl)-L-arginine (see all 10)103960-56-1--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/110 Novoseek inferred chemical compound relationships for ADPRH gene (see all 110)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp-ribosylarginine 85.9 17 7898453 (3), 8349667 (3), 8527484 (2), 1375222 (2) (see all 10)
    s-adenosylhomocysteine 85.1 136 1588558 (1), 8863793 (1), 8910410 (1), 9232649 (1) (see all 62)
    paraoxon 82.8 14 16851427 (2), 20138483 (1), 12580606 (1), 11445174 (1) (see all 13)
    carbocyclic 3-deazaadenosine 77.3 4 1846389 (1), 9708366 (1), 2088208 (1)
    2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid 76.3 4 16964968 (2), 9244273 (1)
    neplanocin a 75.5 7 1588558 (1), 9708366 (1), 2088208 (1), 12919315 (1)
    5'-noraristeromycin 73.5 1 7699695 (1)
    xyloglucan 70.4 25 15557263 (2), 15890523 (2), 12376643 (1), 18158908 (1) (see all 13)
    aristeromycin 69 5 1588558 (1), 9708366 (1), 12919315 (1)
    10-formyltetrahydrofolate 67.5 9 17057331 (2), 10585460 (2), 11320079 (2), 12684508 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about ADPRH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADPRH gene: 
    NM_001125.2  

    Unigene Cluster for ADPRH:

    ADP-ribosylarginine hydrolase
    Hs.99884  [show with all ESTs]
    Unigene Representative Sequence: BC020574
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478399 ENST00000481816 ENST00000471850 ENST00000485496 ENST00000478927
    ENST00000357003(uc003ecs.3 uc010hqv.3 uc011bjb.2 uc003ect.3)
    ENST00000465513
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADPRH
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ADPRH (see all 10):
    hsa-miR-550a hsa-miR-516b hsa-miR-767-3p hsa-miR-624 hsa-miR-373* hsa-miR-3150b-3p hsa-miR-130b* hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidADPRH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADPRH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADPRH
    Clone
    Products:
         
    OriGene clones in human, mouse for ADPRH (see all 8)
    OriGene ORF clones in mouse, rat for ADPRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADPRH (NM_001125)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADPRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADPRH
    Sirion Biotech Customized lentivirus for stable overexpression of ADPRH 
                         Customized lentivirus expression plasmids for stable overexpression of ADPRH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADPRH
    OriGene qSTAR qPCR primer pairs in human, mouse for ADPRH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADPRH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADPRH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADPRH

    Additional mRNA sequence: 

    AK291787.1 AK304560.1 AK313369.1 BC020574.1 BC063883.1 BC074769.2 L13291.1 

    5 DOTS entries:

    DT.212864  DT.100674059  DT.120895274  DT.40119862  DT.120895275 

    24/74 AceView cDNA sequences (see all 74):

    AI276826 AI433130 BX116501 F19293 AA701516 AA831153 AI814258 BX098610 
    AA541262 BC020574 AI216425 N45458 AA418675 AA825835 L13291 AI343644 
    BU752014 AI280361 AA721687 AI554872 NM_001125 BC063883 BC074769 BF510789 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -           -                                       
    SP2:                    -     -     -                                       
    SP3:                                -                                       
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for ADPRH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADPRH expression in normal human tissues (normalized intensities)      ADPRH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTCCTT
    ADPRH Expression
    About this image


    ADPRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Respiratory System)    fully expand to see all 3 entries
             monocyte-derived macrophage   
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See ADPRH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADPRH

    SOURCE GeneReport for Unigene cluster: Hs.99884
        SABiosciences Custom PCR Arrays for ADPRH
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADPRH
    OriGene qSTAR qPCR primer pairs in human, mouse for ADPRH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADPRH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADPRH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADPRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADPRH gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adprh1 , 5 ADP-ribosylarginine hydrolase1, 5 82.35(n)1
    82.54(a)1
      16 (26.86 cM)5
    115441  NM_007414.31  NP_031440.11 
     384453995 
    chicken
    (Gallus gallus)
    Aves ADPRH1 ADP-ribosylarginine hydrolase 52.89(n)
    53(a)
      426545  XM_424183.3  XP_424183.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADPRH6
    --
    Uncharacterized protein
    60(a)
    55(a)
    1 ↔ 1
    possible ortholog
    3(162461654-162470607)
    GL343287.1(662714-667757)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96162 Transcribed sequence with weak similarity to protein more 72.66(n)    137716101 
    zebrafish
    (Danio rerio)
    Actinopterygii adprh1 ADP-ribosylarginine hydrolase 55.52(n)
    53.78(a)
      445059  NM_001003453.1  NP_001003453.1 


    ENSEMBL Gene Tree for ADPRH (if available)
    TreeFam Gene Tree for ADPRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADPRH gene
    ADPRHL12  
    1 SIMAP similar gene for ADPRH using alignment to 2 protein entries:     ADPRH_HUMAN (see all proteins):
    ADPRHL1

    ADPRH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 SNPs in ADPRH are shown (see all 301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669204391,2
    C,F--119296532(+) TTTGAC/TAGTTG 1 -- us2k16Minor allele frequency- T:0.21WA NA EA 364
    rs596392761,2
    C,F--119296569(+) AATATG/ACCATA 1 -- us2k16Minor allele frequency- A:0.21WA NA EA 364
    rs1418512431,2
    C--119296572(+) ATGCCA/GTATAA 1 -- us2k10--------
    rs746990821,2
    C,F--119296631(+) AAAGGG/ATAAAA 1 -- us2k11Minor allele frequency- A:0.19EA 120
    rs1863915331,2
    --119296669(+) ACTTAA/CTTTGC 1 -- us2k10--------
    rs595297971,2
    C,F--119296682(+) TGCTTG/ACTTTT 1 -- us2k16Minor allele frequency- A:0.21WA NA EA 364
    rs1456071791,2
    C--119296706(+) TAGTCA/GATTTT 1 -- us2k10--------
    rs775542801,2
    F--119296753(+) TACATA/GACTAA 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1453271421,2
    --119296923(+) CAGAAA/GGCCCA 1 -- us2k10--------
    rs1491744351,2
    --119297010(+) TGCTTG/TCTCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADPRH (119298115 - 119308792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADPRH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522542CNV Loss19592680
    nsv3963CNV Loss18451855
    nsv829695CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADPRH
    DNA2.0 Custom Variant and Variant Library Synthesis for ADPRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603081    OMIM disorders: --

    20/37 diseases for ADPRH (see all 37):    About MalaCards
    glycine n-methyltransferase deficiency    mucolipidosis ii    tyrosinemia    fabry disease
    mucolipidosis    gaucher's disease    lysosomal storage disease    kidney cancer
    hyperhomocysteinemia    leukodystrophy    tuberculosis    teratocarcinoma
    eclampsia    pre-eclampsia    parkinson's disease    meningitis
    colon adenocarcinoma    gingivitis    choroiditis    ischemia


    ADPRH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/32 Novoseek inferred disease relationships for ADPRH gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    i-cell disease 66.8 1 14657016 (1)
    sphingolipidoses 63.8 1 7477413 (1)
    lysosomal storage diseases 46 1 18259769 (1)
    gaucher disease 30.3 2 15266399 (1), 10037442 (1)
    tyrosinemias 26.1 1 7550234 (1)
    colon adenocarcinoma 19.8 1 1968064 (1)
    gram-negative bacterial infections 19.2 1 16155573 (1)
    fabry disease 10.3 1 2164077 (1)
    rheumatoid arthritis 5.39 1 10576413 (1)
    immunodeficiency 4.7 3 9708357 (1), 1937556 (1), 9396786 (1)


    Export disorders for ADPRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADPRH gene, integrated from 9 sources (see all 477):
    (articles sorted by number of sources associating them with ADPRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PubMed id 8349667)1, 2, 3, 9 Takada T.... Moss J. (1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PubMed id 12070318)1, 3 Glowacki G....Koch-Nolte F. (2002)
    4. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    5. Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of hu man ADP-ribosylhydrolase 1. (PubMed id 19407395)1 Kernstock S....Mueller-Dieckmann C. (2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. (PubMed id 15546898)1 Weber F....Eng C. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The alpha 7 integrin as a target protein for cell surface mono-ADP-ribosylation in muscle cells. (PubMed id 9193669)1 Zolkiewska A. and Moss J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 141 HGNC: 269 AceView: ADPRH Ensembl:ENSG00000144843 euGenes: HUgn141
    ECgene: ADPRH H-InvDB: ADPRH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADPRH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADPRH gene:
    Search GeneIP for patents involving ADPRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADPRH  
     OriGene qPCR primer pairs and template standards for ADPRH   OriGene Protein Over-expression Lysate for ADPRH  
     OriGene MassSpec something-or-other for ADPRH   OriGene clones in human, mouse for ADPRH  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADPRH   OriGene Purified Protein for ADPRH  
     OriGene ORF clones in mouse, rat for ADPRH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADPRH   OriGene Custom Protein Services for ADPRH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADPRH
     QIAGEN SeqTarget long-range PCR primers for resequencing ADPRH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADPRH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADPRH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADPRH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADPRH
     GenScript Custom Purified and Recombinant Proteins Services for ADPRH GenScript cDNA clones with any tag delivered in your preferred vector for ADPRH
     GenScript Custom Assay Services for ADPRH GenScript Custom Superior Antibodies Services for ADPRH
     GenScript Custom overexpressing Cell Line Services for ADPRH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADPRH promoter
     Search Chromatin IP Primers for ADPRH
     RT2 qPCR Primer Assay in human, mouse, rat ADPRH
     Search GNC Networks for ADPRH
     SABiosciences Custom PCR Arrays for ADPRH
     Search Tocris compounds for ADPRH
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ADPRH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for ADPRH
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADPRH antibodies
     ADPRH proteins
     ADPRH lysates
     Antibodies for ADPRH
     See all of Abcam's Antibodies, Kits and Proteins for ADPRH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ADPRH




     Proteins for ADPRH
     Antibodies for ADPRH
     ELISAs for ADPRH
     CLIAs for ADPRH
     Search LifeMap BioReagents cell lines for ADPRH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRH
     SwitchGear 3'UTR luciferase reporter plasmids for ADPRH
     SwitchGear Promoter luciferase reporter plasmids for ADPRH
     Search ThermoFisher Antibodies for ADPRH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADPRH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADPRH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADPRH
    Customized:
     lentivirus for stable overexpression of ADPRH
     lentivirus expression plasmids for stable overexpression of ADPRH
     adenovirus for overexpression of ADPRH
     LSBio Antibodies in human, mouse, rat for ADPRH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADPRH gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4