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Aliases for ADPRH Gene

Aliases for ADPRH Gene

  • ADP-Ribosylarginine Hydrolase 2 3 4 5
  • [Protein ADP-Ribosylarginine] Hydrolase 2 3
  • ADP-Ribose-L-Arginine Cleaving Enzyme 3 4
  • EC 3.2.2.19 4 61
  • ARH1 3 4

External Ids for ADPRH Gene

Previous GeneCards Identifiers for ADPRH Gene

  • GC03P115940
  • GC03P118926
  • GC03P120579
  • GC03P120619
  • GC03P120781
  • GC03P119298
  • GC03P116674

Summaries for ADPRH Gene

Entrez Gene Summary for ADPRH Gene

  • The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ADPRH Gene

ADPRH (ADP-Ribosylarginine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRH include Glycine N-Methyltransferase Deficiency and Parkinson Disease Susceptibility. GO annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot for ADPRH Gene

  • Catalyzes the reverse reaction of mono-ADP-ribosylation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPRH Gene

Genomics for ADPRH Gene

Regulatory Elements for ADPRH Gene

Enhancers for ADPRH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G119626 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.8 +50.1 50126 5.2 PKNOX1 KLF17 RAD21 YY1 ZNF766 GATA2 SCRT2 FOS RELB IKZF2 ADPRH MAATS1 RPL10P7 COX17 CD80 POPDC2 ARHGAP31 PLA1A GPR156 GSK3B
GH03G119557 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.7 -18.7 -18735 5.8 HDGF PKNOX1 WRNIP1 SIN3A YY1 TCF12 ZNF766 ZNF143 ZNF207 FOS CD80 ADPRH ARHGAP31 TMEM39A
GH03G119635 2 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +58.9 58892 4.5 HDGF PKNOX1 ARNT WRNIP1 SIN3A ZNF766 ZNF143 FOS JUNB REST RPL10P7 ADPRH COX17 ARHGAP31 MAATS1 PLA1A GSK3B POPDC2
GH03G119578 1.2 ENCODE dbSUPER 21 +0.6 578 2.4 HDGF WRNIP1 SIN3A DMAP1 YY1 ZNF207 REST ZNF579 NBN STAT3 ADPRH CD80 MAATS1 ENSG00000272967 PLA1A
GH03G119554 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -23.3 -23301 2.0 TBP FOXA2 ZSCAN4 WRNIP1 RAD21 RELB IKZF2 ZNF654 SMAD5 REST ADPRH ARHGAP31 CD80 TIMMDC1 COX17 GC03M119536
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADPRH on UCSC Golden Path with GeneCards custom track

Promoters for ADPRH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157103 532 1201 HDGF TBP CBX3 WRNIP1 ZBTB40 YY1 EGR1 ETV6 IKZF2 HCFC1

Genomic Location for ADPRH Gene

Chromosome:
3
Start:
119,579,268 bp from pter
End:
119,589,945 bp from pter
Size:
10,678 bases
Orientation:
Plus strand

Genomic View for ADPRH Gene

Genes around ADPRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPRH Gene

Proteins for ADPRH Gene

  • Protein details for ADPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54922-ADPRH_HUMAN
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
    Protein Accession:
    P54922
    Secondary Accessions:
    • B2R8H1
    • D3DN83

    Protein attributes for ADPRH Gene

    Size:
    357 amino acids
    Molecular mass:
    39507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADPRH Gene

neXtProt entry for ADPRH Gene

Selected DME Specific Peptides for ADPRH Gene

P54922:
  • WRVSDDT
  • IAGCWWGVM
  • VKERDQFY
  • SGWGGSSGHD

Post-translational modifications for ADPRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ADPRH Gene

Protein Domains for ADPRH Gene

Suggested Antigen Peptide Sequences for ADPRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54922

UniProtKB/Swiss-Prot:

ADPRH_HUMAN :
  • Belongs to the ADP-ribosylglycohydrolase family.
Family:
  • Belongs to the ADP-ribosylglycohydrolase family.
genes like me logo Genes that share domains with ADPRH: view

No data available for Gene Families for ADPRH Gene

Function for ADPRH Gene

Molecular function for ADPRH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine.
UniProtKB/Swiss-Prot CatalyticActivity:
N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine.
UniProtKB/Swiss-Prot Function:
Catalyzes the reverse reaction of mono-ADP-ribosylation.

Enzyme Numbers (IUBMB) for ADPRH Gene

Gene Ontology (GO) - Molecular Function for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003875 ADP-ribosylarginine hydrolase activity IMP 8349667
GO:0005096 NOT GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADPRH: view
genes like me logo Genes that share phenotypes with ADPRH: view

Animal Models for ADPRH Gene

MGI Knock Outs for ADPRH:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADPRH Gene

Localization for ADPRH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADPRH gene
Compartment Confidence
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 NOT endomembrane system IBA --
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADPRH Gene

Pathways & Interactions for ADPRH Gene

SuperPathways for ADPRH Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IMP 8349667
GO:0006886 NOT intracellular protein transport IBA --
GO:0031338 NOT regulation of vesicle fusion IBA --
GO:0051725 protein de-ADP-ribosylation IEA --
GO:0090630 NOT activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with ADPRH: view

No data available for Pathways by source and SIGNOR curated interactions for ADPRH Gene

Drugs & Compounds for ADPRH Gene

(44) Drugs for ADPRH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
L-Arginine Approved Nutra Full agonist, Agonist 0

(71) Additional Compounds for ADPRH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
ADP-Ribosyl-L-arginine
  • N(Omega)-(ADP-D-ribosyl)-arginine
  • N(Omega)-(ADP-D-ribosyl)-L-arginine
  • N(Omega)-(ADP-delta-ribosyl)-arginine
  • N(Omega)-(ADP-delta-ribosyl)-L-arginine
  • N(w)-(ADP-D-Ribosyl)-arginine
103960-56-1
genes like me logo Genes that share compounds with ADPRH: view

Transcripts for ADPRH Gene

Unigene Clusters for ADPRH Gene

ADP-ribosylarginine hydrolase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for ADPRH Gene

GeneLoc Exon Structure for
ADPRH
ECgene alternative splicing isoforms for
ADPRH

Expression for ADPRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADPRH Gene

Protein differential expression in normal tissues from HIPED for ADPRH Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Spleen (8.7), and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADPRH Gene



Protein tissue co-expression partners for ADPRH Gene

NURSA nuclear receptor signaling pathways regulating expression of ADPRH Gene:

ADPRH

SOURCE GeneReport for Unigene cluster for ADPRH Gene:

Hs.99884

Evidence on tissue expression from TISSUES for ADPRH Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ADPRH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADPRH Gene

Orthologs for ADPRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADPRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPRH 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia ADPRH 34 35
  • 88.7 (n)
cow
(Bos Taurus)
Mammalia ADPRH 34 35
  • 87.9 (n)
mouse
(Mus musculus)
Mammalia Adprh 34 16 35
  • 82.35 (n)
rat
(Rattus norvegicus)
Mammalia Adprh 34
  • 82.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADPRH 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADPRH 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADPRH 35 34
  • 68.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPRH 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adprh 34
  • 67.63 (n)
Str.9616 34
zebrafish
(Danio rerio)
Actinopterygii adprh 35
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ADPRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADPRH Gene

ENSEMBL:
Gene Tree for ADPRH (if available)
TreeFam:
Gene Tree for ADPRH (if available)

Paralogs for ADPRH Gene

Paralogs for ADPRH Gene

(1) SIMAP similar genes for ADPRH Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADPRH: view

Variants for ADPRH Gene

Sequence variations from dbSNP and Humsavar for ADPRH Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000316758 -- 119,588,977(+) CCATG(C/G)TAAAC utr-variant-3-prime
rs1000798660 -- 119,578,864(+) GGGGG(C/T)TGGAG upstream-variant-2KB
rs1001140618 -- 119,585,120(+) ACCAA(A/C/G)GGGCC intron-variant
rs1001464032 -- 119,581,960(+) TGTTC(A/C)TACAT intron-variant
rs1001581272 -- 119,583,770(+) TGGCC(A/G)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADPRH Gene

Variant ID Type Subtype PubMed ID
nsv3963 CNV deletion 18451855
nsv522542 CNV loss 19592680
nsv829695 CNV loss 17160897

Variation tolerance for ADPRH Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADPRH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADPRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPRH Gene

Disorders for ADPRH Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADPRH Gene - From: Novoseek and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADPRH in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADPRH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPRH
genes like me logo Genes that share disorders with ADPRH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADPRH Gene

Publications for ADPRH Gene

  1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PMID: 8349667) Takada T. … Moss J. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64

Products for ADPRH Gene

Sources for ADPRH Gene

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