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ADPRH Gene

protein-coding   GIFtS: 56
GCID: GC03P119298

ADP-Ribosylarginine Hydrolase

  See ADPRH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylarginine Hydrolase1 2 3
ARH12 3
ADP-Ribose-L-Arginine Cleaving Enzyme2 3
EC 3.2.2.193 8
[Protein ADP-Ribosylarginine] Hydrolase2

External Ids:    HGNC: 2691   Entrez Gene: 1412   Ensembl: ENSG000001448437   OMIM: 6030815   UniProtKB: P549223   

Export aliases for ADPRH gene to outside databases

Previous GC identifers: GC03P115940 GC03P118926 GC03P120579 GC03P120619 GC03P120781 GC03P116674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADPRH Gene:
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the
ADP-ribosylation cycle. Unlike the rat and mouse enzymes, which require DTT for maximal activity, the human
enzyme is DTT-independent. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADPRH Gene:
ADPRH (ADP-ribosylarginine hydrolase) is a protein-coding gene. Diseases associated with ADPRH include glycine n-methyltransferase deficiency, and mucolipidosis ii. GO annotations related to this gene include ADP-ribosylarginine hydrolase activity and magnesium ion binding. An important paralog of this gene is ADPRHL1.

UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922
Function: Catalyzes the reverse reaction of mono-ADP-ribosylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADPRH gene promoter:
         HEN1   STAT1   AP-1   Zic1   ATF-2   c-Myb   c-Jun   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADPRH promoter sequence
   Search Chromatin IP Primers for ADPRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADPRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.31-q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.31-q13.33

ADPRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPRH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P119298:  view genomic region     (about GC identifiers)

Start:
119,298,115 bp from pter      End:
119,308,792 bp from pter
Size:
10,678 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922 (See protein sequence)
Recommended Name: [Protein ADP-ribosylarginine] hydrolase  
Size: 357 amino acids; 39507 Da
1 PDB 3D structure from and Proteopedia for ADPRH:
3HFW (3D)    
Secondary accessions: B2R8H1 D3DN83

Explore the universe of human proteins at neXtProt for ADPRH: NX_P54922

Explore proteomics data for ADPRH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ADPRH (P54922)
     WRVSDDT  VKERDQFY  IAGCWWGVM  SGWGGSSGHD 


    See ADPRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001116.1  
    ENSEMBL proteins: 
     ENSP00000420200   ENSP00000419703   ENSP00000417528   ENSP00000349496   ENSP00000417430  

    ADPRH Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADPRH

     
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    Search eBioscience for ELISAs for ADPRH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005502 Ribosyl_crysJ1
     IPR012108 ADP-ribosylarg_hydro

    Graphical View of Domain Structure for InterPro Entry P54922

    ProtoNet protein and cluster: P54922

    1 Blocks protein domain: IPB005502 ADP-ribosylglycohydrolase

    UniProtKB/Swiss-Prot: ADPRH_HUMAN, P54922
    Similarity: Belongs to the ADP-ribosylglycohydrolase family


    Find genes that share domains with ADPRH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADPRH_HUMAN, P54922
    Function: Catalyzes the reverse reaction of mono-ADP-ribosylation
    Catalytic activity: Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine
    Catalytic activity: N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine

         Enzyme Number (IUBMB): EC 3.2.2.191 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003875ADP-ribosylarginine hydrolase activity IMP8349667
         
    Find genes that share ontologies with ADPRH           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adprh):
     immune system 

    Find genes that share phenotypes with ADPRH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adprhtm1Jlms for ADPRH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADPRH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADPRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADPRH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADPRH

    miRNA
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    miRTarBase miRNAs that target ADPRH:
    hsa-mir-124-3p (MIRT022142)

    Block miRNA regulation of human, mouse, rat ADPRH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADPRH (see all 10):
    hsa-miR-550a hsa-miR-516b hsa-miR-767-3p hsa-miR-624 hsa-miR-373* hsa-miR-3150b-3p hsa-miR-130b* hsa-miR-924
    SwitchGear 3'UTR luciferase reporter plasmidADPRH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADPRH

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADPRH
    Interactions:

        Search GeneGlobe Interaction Network for ADPRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ADPRH (P549222, 3 ENSP000003494964) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H1AQ025392, 3, ENSP000002445734MINT-7288424 I2D: score=1 STRING: ENSP00000244573
    CREMENSP000002653724STRING: ENSP00000265372
    ENSG00000225164ENSP000004094444STRING: ENSP00000409444
    IFRD2ENSP000003989714STRING: ENSP00000398971
    PARD3ENSP000003639214STRING: ENSP00000363921
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IMP8349667
    GO:0051725protein de-ADP-ribosylation IEA--

    Find genes that share ontologies with ADPRH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADPRH

    5 HMDB Compounds for ADPRH    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    ADP-Ribosyl-L-arginineN2-(ADP-D-ribosyl)-L-arginine (see all 10)103960-56-1--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for ADPRH gene (see all 110)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp-ribosylarginine 85.9 17 7898453 (3), 8349667 (3), 8527484 (2), 1375222 (2) (see all 10)
    s-adenosylhomocysteine 85.1 136 1588558 (1), 8863793 (1), 8910410 (1), 9232649 (1) (see all 62)
    paraoxon 82.8 14 16851427 (2), 20138483 (1), 12580606 (1), 11445174 (1) (see all 13)
    carbocyclic 3-deazaadenosine 77.3 4 1846389 (1), 9708366 (1), 2088208 (1)
    2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid 76.3 4 16964968 (2), 9244273 (1)
    neplanocin a 75.5 7 1588558 (1), 9708366 (1), 2088208 (1), 12919315 (1)
    5'-noraristeromycin 73.5 1 7699695 (1)
    xyloglucan 70.4 25 15557263 (2), 15890523 (2), 12376643 (1), 18158908 (1) (see all 13)
    aristeromycin 69 5 1588558 (1), 9708366 (1), 12919315 (1)
    10-formyltetrahydrofolate 67.5 9 17057331 (2), 10585460 (2), 11320079 (2), 12684508 (1) (see all 5)



    Find genes that share compounds with ADPRH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADPRH gene: 
    NM_001125.2  

    Unigene Cluster for ADPRH:

    ADP-ribosylarginine hydrolase
    Hs.99884  [show with all ESTs]
    Unigene Representative Sequence: BC020574
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478399 ENST00000481816 ENST00000471850 ENST00000485496 ENST00000478927
    ENST00000357003(uc003ecs.3 uc010hqv.3 uc011bjb.2 uc003ect.3)
    ENST00000465513
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADPRH (see all 10):
    hsa-miR-550a hsa-miR-516b hsa-miR-767-3p hsa-miR-624 hsa-miR-373* hsa-miR-3150b-3p hsa-miR-130b* hsa-miR-924
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ADPRH

    Additional mRNA sequence: 

    AK291787.1 AK304560.1 AK313369.1 BC020574.1 BC063883.1 BC074769.2 L13291.1 

    5 DOTS entries:

    DT.212864  DT.100674059  DT.120895274  DT.40119862  DT.120895275 

    Selected AceView cDNA sequences (see all 74):

    L13291 BX116501 BC074769 F19293 AA701516 BU752014 AI554872 AI216425 
    AI814258 BX098610 BC063883 AA825835 BC020574 AI276826 N45458 AA831153 
    AI433130 AA721687 AI280361 AI343644 AA418675 AA541262 NM_001125 BU728568 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADPRH    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -           -                                       
    SP2:                    -     -     -                                       
    SP3:                                -                                       
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for ADPRH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADPRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTCCTT
    ADPRH Expression
    About this image

    ADPRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADPRH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99884
        Custom PCR Arrays for ADPRH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADPRH gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adprh1 , 5 ADP-ribosylarginine hydrolase1, 5 82.35(n)1
    82.54(a)1
      16 (26.86 cM)5
    115441  NM_007414.31  NP_031440.11 
     384453995 
    chicken
    (Gallus gallus)
    Aves ADPRH1 ADP-ribosylarginine hydrolase 68.11(n)
    67.72(a)
      418452  NM_001278101.1  NP_001265030.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADPRH6
    ADP-ribosylarginine hydrolase
    61(a)
    1 ↔ 1
    3(162461654-162470607)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96162 Transcribed sequence with weak similarity to protein more 72.66(n)    137716101 
    zebrafish
    (Danio rerio)
    Actinopterygii adprh6
    ADP-ribosylarginine hydrolase
    52(a)
    1 ↔ 1
    12(16028129-16075734) ENSDARG00000040712


    ENSEMBL Gene Tree for ADPRH (if available)
    TreeFam Gene Tree for ADPRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADPRH gene
    ADPRHL12  
    1 SIMAP similar gene for ADPRH using alignment to 2 protein entries:     ADPRH_HUMAN (see all proteins):
    ADPRHL1

    Find genes that share paralogs with ADPRH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADPRH (see all 301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669204391,2
    C,F--119296532(+) TTTGAC/TAGTTG 1 -- us2k16Minor allele frequency- T:0.21WA NA EA 364
    rs596392761,2
    C,F--119296569(+) AATATG/ACCATA 1 -- us2k16Minor allele frequency- A:0.21WA NA EA 364
    rs1418512431,2
    C--119296572(+) ATGCCA/GTATAA 1 -- us2k10--------
    rs746990821,2
    C,F--119296631(+) AAAGGG/ATAAAA 1 -- us2k11Minor allele frequency- A:0.19EA 120
    rs1863915331,2
    --119296669(+) ACTTAA/CTTTGC 1 -- us2k10--------
    rs595297971,2
    C,F--119296682(+) TGCTTG/ACTTTT 1 -- us2k16Minor allele frequency- A:0.21WA NA EA 364
    rs1456071791,2
    C--119296706(+) TAGTCA/GATTTT 1 -- us2k10--------
    rs775542801,2
    F--119296753(+) TACATA/GACTAA 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1453271421,2
    --119296923(+) CAGAAA/GGCCCA 1 -- us2k10--------
    rs1491744351,2
    --119297010(+) TGCTTG/TCTCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADPRH (119298115 - 119308792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADPRH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522542CNV Loss19592680
    nsv3963CNV Loss18451855
    nsv829695CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603081    OMIM disorders: --

    5 diseases for ADPRH:    
    About MalaCards
    glycine n-methyltransferase deficiency    mucolipidosis ii    tyrosinemia    kidney cancer
    malaria


    Find genes that share disorders with ADPRH           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADPRH gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    i-cell disease 66.8 1 14657016 (1)
    sphingolipidoses 63.8 1 7477413 (1)
    lysosomal storage diseases 46 1 18259769 (1)
    gaucher disease 30.3 2 15266399 (1), 10037442 (1)
    tyrosinemias 26.1 1 7550234 (1)
    colon adenocarcinoma 19.8 1 1968064 (1)
    gram-negative bacterial infections 19.2 1 16155573 (1)
    fabry disease 10.3 1 2164077 (1)
    rheumatoid arthritis 5.39 1 10576413 (1)
    immunodeficiency 4.7 3 9708357 (1), 1937556 (1), 9396786 (1)


    Export disorders for ADPRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADPRH gene, integrated from 10 sources (see all 478):
    (articles sorted by number of sources associating them with ADPRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. (PubMed id 8349667)1, 2, 3, 9 Takada T.... Moss J. (J. Biol. Chem. 1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PubMed id 12070318)1, 3 Glowacki G.... Koch-Nolte F. (Protein Sci. 2002)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    6. Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. (PubMed id 19407395)1 Kernstock S....Mueller-Dieckmann C. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. (PubMed id 15546898)1 Weber F....Eng C. (J. Clin. Endocrinol. Metab. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 141 HGNC: 269 AceView: ADPRH Ensembl:ENSG00000144843 euGenes: HUgn141
    ECgene: ADPRH H-InvDB: ADPRH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADPRH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADPRH gene:
    Search GeneIP for patents involving ADPRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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