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Aliases for ADPGK Gene

Aliases for ADPGK Gene

  • ADP-Dependent Glucokinase 2 3
  • RbBP-35 3 4
  • ADP-GK 3 4
  • ATP-Dependent Glucokinase 3
  • 2610017G09Rik 3
  • EC 2.7.1.147 4

External Ids for ADPGK Gene

Previous GeneCards Identifiers for ADPGK Gene

  • GC15M070830
  • GC15M073043
  • GC15M049874

Summaries for ADPGK Gene

Entrez Gene Summary for ADPGK Gene

  • ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADPGK Gene

ADPGK (ADP-Dependent Glucokinase) is a Protein Coding gene. Diseases associated with ADPGK include monogenic diabetes. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include ADP-specific glucokinase activity.

UniProtKB/Swiss-Prot for ADPGK Gene

  • Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Wiki entry for ADPGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPGK Gene

Genomics for ADPGK Gene

Regulatory Elements for ADPGK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADPGK Gene

Start:
72,751,367 bp from pter
End:
72,785,846 bp from pter
Size:
34,480 bases
Orientation:
Minus strand

Genomic View for ADPGK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADPGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPGK Gene

Proteins for ADPGK Gene

  • Protein details for ADPGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR6-ADPGK_HUMAN
    Recommended name:
    ADP-dependent glucokinase
    Protein Accession:
    Q9BRR6
    Secondary Accessions:
    • Q49AU7
    • Q8NBI1
    • Q8WZ90
    • Q96NF8
    • Q9H0A7

    Protein attributes for ADPGK Gene

    Size:
    497 amino acids
    Molecular mass:
    54089 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ADPGK Gene

neXtProt entry for ADPGK Gene

Proteomics data for ADPGK Gene at MOPED

Post-translational modifications for ADPGK Gene

  • Ubiquitination at Lys125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADPGK Gene

Domains for ADPGK Gene

Protein Domains for ADPGK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADPGK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRR6

UniProtKB/Swiss-Prot:

ADPGK_HUMAN :
  • Q9BRR6
Domain:
  • Contains 1 ADPK (ADP-dependent kinase) domain.
Family:
  • Belongs to the ADP-dependent glucokinase family.
genes like me logo Genes that share domains with ADPGK: view

No data available for Gene Families for ADPGK Gene

Function for ADPGK Gene

Molecular function for ADPGK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ADP + D-glucose = AMP + D-glucose 6-phosphate
UniProtKB/Swiss-Prot Function: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Enzyme Numbers (IUBMB) for ADPGK Gene

Gene Ontology (GO) - Molecular Function for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
GO:0043843 ADP-specific glucokinase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADPGK: view

Animal Model Products

CRISPR Products

miRNA for ADPGK Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADPGK Gene

Localization for ADPGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADPGK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPGK Gene COMPARTMENTS Subcellular localization image for ADPGK gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA 23168256
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ADPGK: view

Pathways for ADPGK Gene

genes like me logo Genes that share pathways with ADPGK: view

Pathways by source for ADPGK Gene

UniProtKB/Swiss-Prot Q9BRR6-ADPGK_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis.

Gene Ontology (GO) - Biological Process for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006096 glycolytic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ADPGK: view

Compounds for ADPGK Gene

(5) HMDB Compounds for ADPGK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
ADP
  • adenosindiphosphorsaeure
58-64-0
D-Glucose
  • (+)-Glucose
50-99-7
Glucose 6-phosphate
  • D(+)-Glucopyranose 6-phosphate
56-73-5
Magnesium
  • Magnesium
7439-95-4

(4) Novoseek inferred chemical compound relationships for ADPGK Gene

Compound -log(P) Hits PubMed IDs
polyphosphate 88.5 6
glucose 6-phosphate 54.5 1
atp 53.2 16
glucose 29.1 1
genes like me logo Genes that share compounds with ADPGK: view

Transcripts for ADPGK Gene

Unigene Clusters for ADPGK Gene

ADP-dependent glucokinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADPGK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - -
SP11: - - - - - - - - - - - - - -
SP12:
SP13: - - - - - -
SP14: - - - - - -
SP15: - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - -

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - -

Relevant External Links for ADPGK Gene

GeneLoc Exon Structure for
ADPGK
ECgene alternative splicing isoforms for
ADPGK

Expression for ADPGK Gene

mRNA expression in normal human tissues for ADPGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADPGK Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADPGK Gene

SOURCE GeneReport for Unigene cluster for ADPGK Gene Hs.654636

genes like me logo Genes that share expressions with ADPGK: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADPGK Gene

Orthologs for ADPGK Gene

This gene was present in the common ancestor of animals.

Orthologs for ADPGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPGK 35
  • 98.79 (n)
  • 97.98 (a)
ADPGK 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADPGK 35
  • 91.25 (n)
  • 94.14 (a)
ADPGK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPGK 35
  • 90.8 (n)
  • 93.31 (a)
ADPGK 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adpgk 35
  • 89.41 (n)
  • 91.7 (a)
Adpgk 16
Adpgk 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADPGK 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPGK 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adpgk 35
  • 89.34 (n)
  • 92.11 (a)
chicken
(Gallus gallus)
Aves ADPGK 35
  • 74.13 (n)
  • 77.41 (a)
ADPGK 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPGK 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489920 35
  • 64.4 (n)
  • 63.58 (a)
zebrafish
(Danio rerio)
Actinopterygii adpgk 35
  • 64.76 (n)
  • 64.49 (a)
adpgk 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6650 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C50D2.7 35
  • 47.69 (n)
  • 38.55 (a)
C50D2.7 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8122 36
  • 44 (a)
OneToOne
Species with no ortholog for ADPGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADPGK Gene

ENSEMBL:
Gene Tree for ADPGK (if available)
TreeFam:
Gene Tree for ADPGK (if available)

Paralogs for ADPGK Gene

Selected SIMAP similar genes for ADPGK Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ADPGK Gene

genes like me logo Genes that share paralogs with ADPGK: view

No data available for Paralogs for ADPGK Gene

Variants for ADPGK Gene

Sequence variations from dbSNP and Humsavar for ADPGK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9460 -- 72,752,234(-) TTAAA(C/T)TGTAT utr-variant-3-prime, nc-transcript-variant
rs2304597 -- 72,760,090(-) AGTTT(C/T)CCTTT intron-variant, upstream-variant-2KB
rs2304598 -- 72,756,188(-) AGCCT(C/T)TCTTG intron-variant
rs2415167 -- 72,765,976(-) aactt(C/T)taaaa intron-variant
rs3179616 -- 72,757,482(-) CGCCT(A/G)TAATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADPGK Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914

Relevant External Links for ADPGK Gene

HapMap Linkage Disequilibrium report
ADPGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPGK Gene

Disorders for ADPGK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADPGK Gene including...

Search for ADPGK Gene in MalaCards »

(1) Novoseek inferred disease relationships for ADPGK Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 37.7 2

Relevant External Links for ADPGK

Genetic Association Database (GAD)
ADPGK
Human Genome Epidemiology (HuGE) Navigator
ADPGK
genes like me logo Genes that share disorders with ADPGK: view

No data available for UniProtKB/Swiss-Prot for ADPGK Gene

Publications for ADPGK Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADPGK Gene

  • Addgene plasmids for ADPGK

Sources for ADPGK Gene

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