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ADPGK Gene

protein-coding   GIFtS: 59
GCID: GC15M073043

ADP-Dependent Glucokinase

  See ADPGK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Dependent Glucokinase1 2     rbBP-352
ADP-GK2 3     EC 2.7.1.1473
2610017G09Rik2     RbBP-353
ATP-Dependent Glucokinase2     

External Ids:    HGNC: 252501   Entrez Gene: 834402   Ensembl: ENSG000001593227   OMIM: 6118615   UniProtKB: Q9BRR63   

Export aliases for ADPGK gene to outside databases

Previous GC identifers: GC15M070830 GC15M049874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADPGK Gene:
ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a
role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 (PubMed 14975750)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ADPGK Gene:
ADPGK (ADP-dependent glucokinase) is a protein-coding gene. Diseases associated with ADPGK include monogenic diabetes, and type 1 diabetes mellitus. GO annotations related to this gene include ADP-specific glucokinase activity.

UniProtKB/Swiss-Prot: ADPGK_HUMAN, Q9BRR6
Function: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
GDP and CDP can replace ADP, but with reduced efficiency (By similarity)

Gene Wiki entry for ADPGK (ADP-specific glucokinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADPGK gene promoter:
         AML1a   MyoD   AP-4   E47   N-Myc   HEN1   CP2   HOXA5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADPGK promoter sequence
   Search Chromatin IP Primers for ADPGK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADPGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

ADPGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADPGK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M073043:  view genomic region     (about GC identifiers)

Start:
73,043,708 bp from pter      End:
73,078,187 bp from pter
Size:
34,480 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ADPGK

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADPGK_HUMAN, Q9BRR6 (See protein sequence)
Recommended Name: ADP-dependent glucokinase precursor  
Size: 497 amino acids; 54089 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subunit: Monomer (By similarity)
Secondary accessions: Q49AU7 Q8NBI1 Q8WZ90 Q96NF8 Q9H0A7
Alternative splicing: 6 isoforms:  Q9BRR6-1   Q9BRR6-2   Q9BRR6-3   Q9BRR6-4   Q9BRR6-5   Q9BRR6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADPGK: NX_Q9BRR6

Explore proteomics data for ADPGK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys125

  • See ADPGK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112574.3  
    ENSEMBL proteins: 
     ENSP00000457572   ENSP00000458102   ENSP00000454707   ENSP00000312250   ENSP00000456387  
     ENSP00000454304   ENSP00000457447   ENSP00000457175   ENSP00000454367   ENSP00000397694  

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    Novus Biologicals ADPGK Proteins
    Novus Biologicals ADPGK Lysates
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    Cloud-Clone Corp. Proteins for ADPGK

     
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    antibodies-online proteins for ADPGK (5 products) 

     
    antibodies-online peptides for ADPGK

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007666 ADP_PFK/GK

    Graphical View of Domain Structure for InterPro Entry Q9BRR6

    ProtoNet protein and cluster: Q9BRR6

    UniProtKB/Swiss-Prot: ADPGK_HUMAN, Q9BRR6
    Similarity: Belongs to the ADP-dependent glucokinase family
    Similarity: Contains 1 ADPK (ADP-dependent kinase) domain


    Find genes that share domains with ADPGK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADPGK_HUMAN, Q9BRR6
    Function: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.
    GDP and CDP can replace ADP, but with reduced efficiency (By similarity)
    Catalytic activity: ADP + D-glucose = AMP + D-glucose 6-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.1471

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
    GO:0043843ADP-specific glucokinase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ADPGK           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADPGK

    miRNA
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    miRTarBase miRNAs that target ADPGK:
    hsa-mir-30a-5p (MIRT005179), hsa-mir-1 (MIRT001393), hsa-mir-769-5p (MIRT039172), hsa-mir-26b-5p (MIRT029519), hsa-mir-24-3p (MIRT030526)

    Block miRNA regulation of human, mouse, rat ADPGK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADPGK (see all 15):
    hsa-miR-203 hsa-miR-3163 hsa-miR-647 hsa-miR-3673 hsa-miR-206 hsa-miR-1 hsa-miR-340 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidADPGK 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ADPGK 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADPGK_HUMAN, Q9BRR6: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    endoplasmic reticulum1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ADPGK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADPGK About    
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis / Gluconeogenesis0.46
    2Carbon metabolism
    Carbon metabolism0.38
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with ADPGK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3 Kegg Pathways  (Kegg details for ADPGK):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: ADPGK_HUMAN, Q9BRR6
    Pathway: Carbohydrate degradation; glycolysis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADPGK
    Interactions:

        Search GeneGlobe Interaction Network for ADPGK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ADPGK (Q9BRR62, 3 ENSP000003122504) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDF9O603832, 3MINT-65317 I2D: score=4 
    TADA3O755282, 3MINT-63211 I2D: score=4 
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2876906 I2D: score=3 STRING: ENSP00000357292
    GPIENSP000003488774STRING: ENSP00000348877
    GALMENSP000002722524STRING: ENSP00000272252
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006096glycolytic process IEA--

    Find genes that share ontologies with ADPGK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADPGK

    5 HMDB Compounds for ADPGK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Glucose 6-phosphateD(+)-Glucopyranose 6-phosphate (see all 11)56-73-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for ADPGK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyphosphate 88.5 6 8380966 (3), 8381043 (2), 8390296 (1)
    glucose 6-phosphate 54.5 1 8703950 (1)
    atp 53.2 19 8380966 (4), 8381043 (4), 15466045 (3), 8390296 (2) (see all 6)
    glucose 29.1 1 15466045 (1)



    Find genes that share compounds with ADPGK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADPGK gene: 
    NM_031284.4  

    Unigene Cluster for ADPGK:

    ADP-dependent glucokinase
    Hs.654636  [show with all ESTs]
    Unigene Representative Sequence: AL832254
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569693 ENST00000567941(uc002avi.4) ENST00000569534 ENST00000311669(uc010ukw.2 uc002avf.4 uc002avh.4 uc002avg.4)
    ENST00000562621(uc002ave.4) ENST00000563907 ENST00000569517 ENST00000567733
    ENST00000565814 ENST00000569058 ENST00000566509 ENST00000562286 ENST00000562823
    ENST00000456471
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADPGK (see all 15):
    hsa-miR-203 hsa-miR-3163 hsa-miR-647 hsa-miR-3673 hsa-miR-206 hsa-miR-1 hsa-miR-340 hsa-miR-3667-3p
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    Addgene plasmids for ADPGK 
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      QuantiTect SYBR Green Assays in human, mouse, rat ADPGK
      QuantiFast Probe-based Assays in human, mouse, rat ADPGK

    Additional mRNA sequence: 

    AF204270.1 AK055526.1 AK057651.1 AK075560.1 AK293282.1 AK294391.1 AL136873.1 AL832254.1 
    BC006112.1 BC018074.1 BC044589.1 CR533447.1 NR_023318.1 NR_023319.1 

    17 DOTS entries:

    DT.95211797  DT.100029745  DT.101960584  DT.100824229  DT.91698565  DT.121041282  DT.95366795  DT.121041366 
    DT.92440224  DT.100824227  DT.117523  DT.91979152  DT.100824228  DT.100824230  DT.121041299  DT.40238368 
    DT.95211819 

    Selected AceView cDNA sequences (see all 291):

    CB528349 AI887741 BE351026 F12814 BQ017065 CD742646 BE018185 AI654085 
    BM822357 BC044589 BF058653 AI925013 CB122030 AI801918 BU622523 AA999949 
    BU633625 AL136873 AI186508 AI583041 AI373229 AI372074 AA300494 AI423352 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADPGK (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
    SP1:                                                  -     -     -     -                                   -     -     -     -                                 
    SP2:                                            -     -     -     -     -                                   -     -     -     -                                 
    SP3:                                            -     -     -     -     -                                   -     -     -     -                                 
    SP4:                                            -     -     -     -     -     -     -     -                 -     -     -     -                                 
    SP5:                                            -     -     -     -     -                                   -     -     -     -     -     -     -     -     -   

    ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ADPGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADPGK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATATTT
    ADPGK Expression
    About this image


    ADPGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ADPGK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADPGK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654636
        Custom PCR Arrays for ADPGK
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADPGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADPGK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adpgk1 , 5 ADP-dependent glucokinase1, 5 89.41(n)1
    91.7(a)1
      9 (32.01 cM)5
    721411  NM_028121.21  NP_082397.11 
     592915725 
    chicken
    (Gallus gallus)
    Aves ADPGK1 ADP-dependent glucokinase 74.13(n)
    77.41(a)
      415317  XM_004943658.1  XP_004943715.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADPGK6
    ADP-dependent glucokinase
    74(a)
    1 ↔ 1
    GL343872.1(34825-45925)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004899201 ADP-dependent glucokinase-like 64.4(n)
    63.58(a)
      100489920  XM_004911252.1  XP_004911309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adpgk1 ADP-dependent glucokinase 64.76(n)
    64.49(a)
      557919  NM_001079965.1  NP_001073434.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66506
    --
    29(a)
    1 ↔ 1
    3L(14024550-14027740)
    worm
    (Caenorhabditis elegans)
    Secernentea C50D2.71 C50D2.7 47.69(n)
    38.55(a)
      173393  NM_061256.4  NP_493657.2 


    ENSEMBL Gene Tree for ADPGK (if available)
    TreeFam Gene Tree for ADPGK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADPGK gene
    1 SIMAP similar gene for ADPGK using alignment to 6 protein entries:     ADPGK_HUMAN (see all proteins):
    DKFZp667C1917

    Find genes that share paralogs with ADPGK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ADPGK
    PGOHUM00000246844


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADPGK (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857224261,2
    --73043229(+) AGATTG/TCCTTA 3 -- int10--------
    rs1906325841,2
    --73043258(+) GCTTTA/GAGTTA 3 -- int10--------
    rs31841831,2
    C--73043903(-) AATTTG/TTTTTT 3 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.00MN NA 186
    rs1808600411,2
    --73044045(+) AAAGCA/GTGATC 3 -- ut31 nc-transcript-variant0--------
    rs1427504471,2
    C--73044132(+) CTGCCA/CTCATA 3 -- ut31 nc-transcript-variant0--------
    rs1396727451,2
    C--73044188(+) TTGAG-/AGCAGGAG 3 -- cds1 nc-transcript-variant0--------
    rs1849281061,2
    --73044222(+) AAATAC/TTGTCA 3 -- ut31 nc-transcript-variant0--------
    rs1886181041,2
    --73044265(+) CCATGA/GGCACT 3 -- ut31 nc-transcript-variant0--------
    rs3723663641,2
    C--73044327(+) TGGGT-/GGAGTG 6 -- ut31 nc-transcript-variant0--------
    rs1135211781,2
    C,F--73044399(+) GGTGAC/AGAAGT 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ADPGK (73043708 - 73078187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADPGK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428307CNV Gain18775914
    dgv755e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADPGK
    DNA2.0 Custom Variant and Variant Library Synthesis for ADPGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611861    OMIM disorders: --

    2 diseases for ADPGK:    
    About MalaCards
    monogenic diabetes    type 1 diabetes mellitus


    Find genes that share disorders with ADPGK           About GenesLikeMe

    1 Novoseek inferred disease relationship for ADPGK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 37.7 2 8390296 (1), 8381043 (1)

    Genetic Association Database (GAD): ADPGK
    Human Genome Epidemiology (HuGE) Navigator: ADPGK (1 document)

    Export disorders for ADPGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADPGK gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ADPGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    7. Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. (PubMed id 23799003)1 Richter S....Wilson W.R. (PLoS ONE 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Expression and role in glycolysis of human ADP-dependent glucokinase. (PubMed id 22219026)1 Richter S....Wilson W.R. (Mol. Cell. Biochem. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83440 HGNC: 25250 AceView: ADPGK Ensembl:ENSG00000159322 euGenes: HUgn83440
    ECgene: ADPGK Kegg: 83440 H-InvDB: ADPGK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADPGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADPGK gene:
    Search GeneIP for patents involving ADPGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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