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Aliases for ADPGK Gene

Aliases for ADPGK Gene

  • ADP-Dependent Glucokinase 2 3 5
  • RbBP-35 3 4
  • ADP-GK 3 4
  • ATP-Dependent Glucokinase 3
  • 2610017G09Rik 3
  • EC 2.7.1.147 4

External Ids for ADPGK Gene

Previous GeneCards Identifiers for ADPGK Gene

  • GC15M070830
  • GC15M073043
  • GC15M049874

Summaries for ADPGK Gene

Entrez Gene Summary for ADPGK Gene

  • ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADPGK Gene

ADPGK (ADP-Dependent Glucokinase) is a Protein Coding gene. Diseases associated with ADPGK include monogenic diabetes. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include kinase activity and ADP-specific glucokinase activity.

UniProtKB/Swiss-Prot for ADPGK Gene

  • Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Wiki entry for ADPGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPGK Gene

Genomics for ADPGK Gene

Regulatory Elements for ADPGK Gene

Genomic Location for ADPGK Gene

Chromosome:
15
Start:
72,751,294 bp from pter
End:
72,785,846 bp from pter
Size:
34,553 bases
Orientation:
Minus strand

Genomic View for ADPGK Gene

Genes around ADPGK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPGK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPGK Gene

Proteins for ADPGK Gene

  • Protein details for ADPGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR6-ADPGK_HUMAN
    Recommended name:
    ADP-dependent glucokinase
    Protein Accession:
    Q9BRR6
    Secondary Accessions:
    • Q49AU7
    • Q8NBI1
    • Q8WZ90
    • Q96NF8
    • Q9H0A7

    Protein attributes for ADPGK Gene

    Size:
    497 amino acids
    Molecular mass:
    54089 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ADPGK Gene

neXtProt entry for ADPGK Gene

Proteomics data for ADPGK Gene at MOPED

Post-translational modifications for ADPGK Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADPGK Gene

Domains & Families for ADPGK Gene

Protein Domains for ADPGK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADPGK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRR6

UniProtKB/Swiss-Prot:

ADPGK_HUMAN :
  • Contains 1 ADPK (ADP-dependent kinase) domain.
  • Belongs to the ADP-dependent glucokinase family.
Domain:
  • Contains 1 ADPK (ADP-dependent kinase) domain.
Family:
  • Belongs to the ADP-dependent glucokinase family.
genes like me logo Genes that share domains with ADPGK: view

No data available for Gene Families for ADPGK Gene

Function for ADPGK Gene

Molecular function for ADPGK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ADP + D-glucose = AMP + D-glucose 6-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Enzyme Numbers (IUBMB) for ADPGK Gene

Gene Ontology (GO) - Molecular Function for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043843 ADP-specific glucokinase activity TAS --
genes like me logo Genes that share ontologies with ADPGK: view
genes like me logo Genes that share phenotypes with ADPGK: view

Animal Models for ADPGK Gene

MGI Knock Outs for ADPGK:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADPGK Gene

Localization for ADPGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADPGK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPGK Gene COMPARTMENTS Subcellular localization image for ADPGK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytoskeleton 2
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ADPGK: view

Pathways & Interactions for ADPGK Gene

genes like me logo Genes that share pathways with ADPGK: view

Pathways by source for ADPGK Gene

UniProtKB/Swiss-Prot Q9BRR6-ADPGK_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis.

Gene Ontology (GO) - Biological Process for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process IEA --
genes like me logo Genes that share ontologies with ADPGK: view

No data available for SIGNOR curated interactions for ADPGK Gene

Drugs & Compounds for ADPGK Gene

(6) Drugs for ADPGK Gene - From: HMDB, Novoseek, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Glucose 6-phosphate Experimental Pharma 0
Beta-D-Glucose Experimental Pharma 0
LY2608204 Pharma GK activator 0
Magnesium Nutra 0

(6) Additional Compounds for ADPGK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
Beta-D-Glucose 6-phosphate
  • beta-D-Glucose 6-(dihydrogen phosphate)
  • beta-D-Glucose 6-phosphate
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7

(1) ApexBio Compounds for ADPGK Gene

Compound Action Cas Number
LY2608204 GK activator 1234703-40-2
genes like me logo Genes that share compounds with ADPGK: view

Transcripts for ADPGK Gene

Unigene Clusters for ADPGK Gene

ADP-dependent glucokinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - -
SP11: - - - - - - - - - - - - - -
SP12:
SP13: - - - - - -
SP14: - - - - - -
SP15: - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - -

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - -

Relevant External Links for ADPGK Gene

GeneLoc Exon Structure for
ADPGK
ECgene alternative splicing isoforms for
ADPGK

Expression for ADPGK Gene

mRNA expression in normal human tissues for ADPGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADPGK Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ADPGK Gene

This gene is overexpressed in Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADPGK Gene



SOURCE GeneReport for Unigene cluster for ADPGK Gene Hs.654636

genes like me logo Genes that share expression patterns with ADPGK: view

Protein tissue co-expression partners for ADPGK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADPGK Gene

Orthologs for ADPGK Gene

This gene was present in the common ancestor of animals.

Orthologs for ADPGK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADPGK 35
  • 91.25 (n)
  • 94.14 (a)
ADPGK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADPGK 35
  • 90.8 (n)
  • 93.31 (a)
ADPGK 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adpgk 35
  • 89.41 (n)
  • 91.7 (a)
Adpgk 16
Adpgk 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADPGK 35
  • 98.79 (n)
  • 97.98 (a)
ADPGK 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adpgk 35
  • 89.34 (n)
  • 92.11 (a)
oppossum
(Monodelphis domestica)
Mammalia ADPGK 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPGK 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADPGK 35
  • 74.13 (n)
  • 77.41 (a)
ADPGK 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADPGK 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489920 35
  • 64.4 (n)
  • 63.58 (a)
zebrafish
(Danio rerio)
Actinopterygii adpgk 35
  • 64.76 (n)
  • 64.49 (a)
adpgk 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6650 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C50D2.7 35
  • 47.69 (n)
  • 38.55 (a)
C50D2.7 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8122 36
  • 44 (a)
OneToOne
Species with no ortholog for ADPGK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADPGK Gene

ENSEMBL:
Gene Tree for ADPGK (if available)
TreeFam:
Gene Tree for ADPGK (if available)

Paralogs for ADPGK Gene

(1) SIMAP similar genes for ADPGK Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ADPGK Gene

genes like me logo Genes that share paralogs with ADPGK: view

No data available for Paralogs for ADPGK Gene

Variants for ADPGK Gene

Sequence variations from dbSNP and Humsavar for ADPGK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs8024644 - 72,760,499(+) GTAGC(C/T)TTGGA intron-variant, nc-transcript-variant, reference, missense
rs9460 -- 72,752,234(-) TTAAA(C/T)TGTAT nc-transcript-variant, utr-variant-3-prime
rs2415167 -- 72,765,976(-) aactt(C/T)taaaa intron-variant
rs2304597 -- 72,760,090(-) AGTTT(C/T)CCTTT intron-variant
rs2304598 -- 72,756,188(-) AGCCT(C/T)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADPGK Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914

Variation tolerance for ADPGK Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADPGK Gene

HapMap Linkage Disequilibrium report
ADPGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPGK Gene

Disorders for ADPGK Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADPGK Gene - From: GeneCards

Disorder Aliases PubMed IDs
monogenic diabetes
- elite association - COSMIC cancer census association via MalaCards
Search ADPGK in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADPGK

Genetic Association Database (GAD)
ADPGK
Human Genome Epidemiology (HuGE) Navigator
ADPGK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPGK
genes like me logo Genes that share disorders with ADPGK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADPGK Gene

Publications for ADPGK Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3
  4. Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. (PMID: 23799003) Richter S. … Wilson W.R. (PLoS ONE 2013) 3
  5. Expression and role in glycolysis of human ADP-dependent glucokinase. (PMID: 22219026) Richter S. … Wilson W.R. (Mol. Cell. Biochem. 2012) 3

Products for ADPGK Gene

Sources for ADPGK Gene

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