Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADPGK Gene

Aliases for ADPGK Gene

  • ADP Dependent Glucokinase 2 3 5
  • RbBP-35 3 4
  • ADP-GK 3 4
  • ADP-Dependent Glucokinase 3
  • ATP-Dependent Glucokinase 3
  • 2610017G09Rik 3
  • EC 2.7.1.147 4

External Ids for ADPGK Gene

Previous GeneCards Identifiers for ADPGK Gene

  • GC15M070830
  • GC15M073043
  • GC15M049874

Summaries for ADPGK Gene

Entrez Gene Summary for ADPGK Gene

  • ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADPGK Gene

ADPGK (ADP Dependent Glucokinase) is a Protein Coding gene. Diseases associated with ADPGK include Monogenic Diabetes. Among its related pathways are Metabolism and Glucose metabolism. GO annotations related to this gene include kinase activity and ADP-specific glucokinase activity.

UniProtKB/Swiss-Prot for ADPGK Gene

  • Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Wiki entry for ADPGK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADPGK Gene

Genomics for ADPGK Gene

Regulatory Elements for ADPGK Gene

Enhancers for ADPGK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072752 0.2 ENCODE 21.1 +33.6 33592 0.2 EGR2 ADPGK BBS4 PIR32168 ADPGK-AS1
GH15F072685 1.2 ENCODE 20 +99.4 99441 2.5 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 ADPGK BBS4 ENSG00000260037 GC15P072708
GH15F072757 0.5 ENCODE 12 +27.7 27688 1.6 HLF ZNF335 JUND GLIS1 FOS PRDM1 ZBTB26 MAFK ZBTB20 NFE2L2 ADPGK BBS4 PIR32168 ADPGK-AS1
GH15F072751 0.4 ENCODE 11.8 +33.9 33852 0.2 POLR2A EGR2 ADPGK PIR32168 ADPGK-AS1
GH15F072781 1.2 FANTOM5 Ensembl ENCODE 11.6 +1.1 1117 5.7 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 BBS4 TMEM202 LOC105370890 ARIH1 ENSG00000260672 ADPGK ENSG00000261187 LOC105370888 HEXA ENSG00000260037
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADPGK on UCSC Golden Path with GeneCards custom track

Genomic Location for ADPGK Gene

Chromosome:
15
Start:
72,751,294 bp from pter
End:
72,785,846 bp from pter
Size:
34,553 bases
Orientation:
Minus strand

Genomic View for ADPGK Gene

Genes around ADPGK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADPGK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADPGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADPGK Gene

Proteins for ADPGK Gene

  • Protein details for ADPGK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR6-ADPGK_HUMAN
    Recommended name:
    ADP-dependent glucokinase
    Protein Accession:
    Q9BRR6
    Secondary Accessions:
    • Q49AU7
    • Q8NBI1
    • Q8WZ90
    • Q96NF8
    • Q9H0A7

    Protein attributes for ADPGK Gene

    Size:
    497 amino acids
    Molecular mass:
    54089 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ADPGK Gene

neXtProt entry for ADPGK Gene

Post-translational modifications for ADPGK Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ADPGK
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADPGK

No data available for DME Specific Peptides for ADPGK Gene

Domains & Families for ADPGK Gene

Protein Domains for ADPGK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADPGK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRR6

UniProtKB/Swiss-Prot:

ADPGK_HUMAN :
  • Contains 1 ADPK (ADP-dependent kinase) domain.
  • Belongs to the ADP-dependent glucokinase family.
Domain:
  • Contains 1 ADPK (ADP-dependent kinase) domain.
Family:
  • Belongs to the ADP-dependent glucokinase family.
genes like me logo Genes that share domains with ADPGK: view

No data available for Gene Families for ADPGK Gene

Function for ADPGK Gene

Molecular function for ADPGK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ADP + D-glucose = AMP + D-glucose 6-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Enzyme Numbers (IUBMB) for ADPGK Gene

Gene Ontology (GO) - Molecular Function for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA --
GO:0043843 ADP-specific glucokinase activity TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADPGK: view
genes like me logo Genes that share phenotypes with ADPGK: view

Animal Models for ADPGK Gene

MGI Knock Outs for ADPGK:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADPGK

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADPGK Gene

Localization for ADPGK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADPGK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADPGK Gene COMPARTMENTS Subcellular localization image for ADPGK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytoskeleton 2
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IDA 23168256
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADPGK: view

Pathways & Interactions for ADPGK Gene

genes like me logo Genes that share pathways with ADPGK: view

Pathways by source for ADPGK Gene

UniProtKB/Swiss-Prot Q9BRR6-ADPGK_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis.

Gene Ontology (GO) - Biological Process for ADPGK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ADPGK: view

No data available for SIGNOR curated interactions for ADPGK Gene

Drugs & Compounds for ADPGK Gene

(8) Drugs for ADPGK Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Glucose 6-phosphate Experimental Pharma 0
Beta-D-Glucose Experimental Pharma 0
beta-D-glucose 6-phosphate Experimental Pharma 0
LY2608204 Pharma GK activator 0

(4) Additional Compounds for ADPGK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7

(1) ApexBio Compounds for ADPGK Gene

Compound Action Cas Number
LY2608204 GK activator 1234703-40-2
genes like me logo Genes that share compounds with ADPGK: view

Transcripts for ADPGK Gene

Unigene Clusters for ADPGK Gene

ADP-dependent glucokinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADPGK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADPGK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - -
SP11: - - - - - - - - - - - - - -
SP12:
SP13: - - - - - -
SP14: - - - - - -
SP15: - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - -

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - -

Relevant External Links for ADPGK Gene

GeneLoc Exon Structure for
ADPGK
ECgene alternative splicing isoforms for
ADPGK

Expression for ADPGK Gene

mRNA expression in normal human tissues for ADPGK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADPGK Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ADPGK Gene

This gene is overexpressed in Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADPGK Gene



Protein tissue co-expression partners for ADPGK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADPGK Gene:

ADPGK

SOURCE GeneReport for Unigene cluster for ADPGK Gene:

Hs.654636
genes like me logo Genes that share expression patterns with ADPGK: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADPGK Gene

Orthologs for ADPGK Gene

This gene was present in the common ancestor of animals.

Orthologs for ADPGK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADPGK 34 35
  • 98.79 (n)
cow
(Bos Taurus)
Mammalia ADPGK 34 35
  • 91.25 (n)
dog
(Canis familiaris)
Mammalia ADPGK 34 35
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Adpgk 34 16 35
  • 89.41 (n)
rat
(Rattus norvegicus)
Mammalia Adpgk 34
  • 89.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ADPGK 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADPGK 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADPGK 34 35
  • 74.13 (n)
lizard
(Anolis carolinensis)
Reptilia ADPGK 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489920 34
  • 64.4 (n)
zebrafish
(Danio rerio)
Actinopterygii adpgk 34 35
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6650 35
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C50D2.7 34 35
  • 47.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8122 35
  • 44 (a)
OneToOne
Species where no ortholog for ADPGK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADPGK Gene

ENSEMBL:
Gene Tree for ADPGK (if available)
TreeFam:
Gene Tree for ADPGK (if available)

Paralogs for ADPGK Gene

(1) SIMAP similar genes for ADPGK Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ADPGK Gene

genes like me logo Genes that share paralogs with ADPGK: view

No data available for Paralogs for ADPGK Gene

Variants for ADPGK Gene

Sequence variations from dbSNP and Humsavar for ADPGK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152150 -- 72,762,693(+) CAGGA(A/C)TAAAC intron-variant
rs10519024 -- 72,773,530(+) TCTAG(C/T)GAAAG intron-variant
rs10656518 -- 72,782,528(+) GTCCA(-/AAA)AAAAA intron-variant, upstream-variant-2KB
rs11072386 -- 72,773,923(+) GAGTG(A/C)AGTGG intron-variant
rs11072387 -- 72,779,432(+) TAGAG(A/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADPGK Gene

Variant ID Type Subtype PubMed ID
esv2760039 CNV gain+loss 17122850
esv3380543 CNV insertion 20981092
nsv1121512 CNV deletion 24896259
nsv428307 CNV gain 18775914

Variation tolerance for ADPGK Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADPGK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADPGK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADPGK Gene

Disorders for ADPGK Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADPGK Gene - From: GeneCards

Disorder Aliases PubMed IDs
monogenic diabetes
- elite association - COSMIC cancer census association via MalaCards
Search ADPGK in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADPGK

Genetic Association Database (GAD)
ADPGK
Human Genome Epidemiology (HuGE) Navigator
ADPGK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADPGK
genes like me logo Genes that share disorders with ADPGK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADPGK Gene

Publications for ADPGK Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ADPGK Gene

Sources for ADPGK Gene

Content
Loading form....