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ADORA3 Gene

protein-coding   GIFtS: 70
GCID: GC01M112025

Adenosine A3 Receptor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine A3 Receptor1 2
A3AR2
AD0262
Adenosine Receptor A32
bA552M11.52

External Ids:    HGNC: 2681   Entrez Gene: 1402   Ensembl: ENSG000001219337   OMIM: 6004455   UniProtKB: Q6P2N63   
UniProtKB: P337653   

Export aliases for ADORA3 gene to outside databases

Previous GC identifers: GC01M112458 GC01M110913 GC01M111144 GC01M111340 GC01M111326 GC01M111739 GC01M111827 GC01M109897


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADORA3 Gene:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled
receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The
receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is
involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been
implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation
and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ADORA3 Gene:
ADORA3 (adenosine A3 receptor) is a protein-coding gene. Diseases associated with ADORA3 include ischemia, and brain ischemia. GO annotations related to this gene include G-protein coupled adenosine receptor activity.

UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6 (see all)
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl
cyclase. Possible role in reproduction

summary for ADORA3 Gene:
The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that
also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats,
with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine
A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion.
The human A3 receptor gene is localized on chromosome 1 (1p21-p13).

Gene Wiki entry for ADORA3 (Adenosine A3 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADORA3 gene promoter:
         CREB   Elk-1   FOXF2   FOXO4   deltaCREB   PPAR-gamma2   Evi-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADORA3 promoter sequence
   Search Chromatin IP Primers for ADORA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADORA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

ADORA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M112025:  view genomic region     (about GC identifiers)

Start:
112,025,970 bp from pter      End:
112,106,597 bp from pter
Size:
80,628 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6 (See protein sequence)
Recommended Name: Protein ADORA3, isoform 3  
Size: 266 amino acids; 30327 Da
Sequence caution: Sequence=AAH41707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH64411.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW56500.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5QNY7
Alternative splicing: 3 isoforms:  Q6P2N6-1   P33765-1   P33765-2   

UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765 (See protein sequence)

Recommended Name: Adenosine receptor A3  
Size: 318 amino acids; 36185 Da
2 PDB 3D structures from and Proteopedia for ADORA3:
1OEA (3D)        1R7N (3D)    
Secondary accessions: A2A3P4 Q6UWU0 Q9BYZ1
Alternative splicing: 3 isoforms:  P33765-1   P33765-2   Q6P2N6-1   

Explore the universe of human proteins at neXtProt for ADORA3: NX_P33765

Explore proteomics data for ADORA3 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-317 may be crucial for rapid desensitization (By similarity)1
  • Glycosylation2 at Asn3, Asn4, Asn12
  • Modification sites at PhosphoSitePlus

  • See ADORA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000668.1  NP_001075445.1  NP_065734.5  

    ENSEMBL proteins: 
     ENSP00000415646   ENSP00000358730   ENSP00000358731   ENSP00000398770   ENSP00000406102  
     ENSP00000241356  
    Reactome Protein details: P33765

    ADORA3 Human Recombinant Protein Products:

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    Novus Biologicals ADORA3 Protein
    Novus Biologicals ADORA3 Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for ADORA3

    ADORA3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADORA3
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    Abcam antibodies for ADORA3 (Q6P2N6, P33765)
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    ADORA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for ADORA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADORA: GPCR / Class A : Adenosine receptors
    VSET: Immunoglobulin superfamily / V-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: A3 receptor
    Adenosine receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013783 Ig-like_fold
     IPR001634 Adenosn_rcpt
     IPR000466 Adeno_A3_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q6P2N6
    Graphical View of Domain Structure for InterPro Entry P33765

    ProtoNet protein and cluster: Q6P2N6

    UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765
    Similarity: Belongs to the G-protein coupled receptor 1 family


    ADORA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: AA3RB_HUMAN, Q6P2N6 (see all)
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl
    cyclase. Possible role in reproduction

         Genatlas biochemistry entry for ADORA3:
    adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled
    receptor superfamily,activating adenylate cyclase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
         
    ADORA3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ADORA3:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adora3):
     behavior/neurological  cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 
     integument  no phenotypic analysis  renal/urinary system  respiratory system  vision/eye 

    ADORA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adora3tm1Jbsn for ADORA3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADORA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADORA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADORA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADORA3

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ADORA3:
    hsa-miR-4291 hsa-miR-2278 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidADORA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADORA3
    Predesigned siRNA for gene silencing in human, mouse, rat ADORA3

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADORA3 (NM_001081976)
    Sino Biological Human cDNA Clone for ADORA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADORA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AA3RB_HUMAN, Q6P2N6: Cell membrane; Multi-pass membrane protein
    AA3R_HUMAN, P33765: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0042629mast cell granule IEA--

    ADORA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADORA3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    Adenosine P1 receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Development A3 receptor signaling
    Development A3 receptor signaling0.65
    5Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ADORA3
        Development A3 receptor signaling
    Signal transduction IP3 signaling

    3 BioSystems Pathways for ADORA3
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs


    2 Reactome Pathways for ADORA3
        G alpha (i) signalling events
    Adenosine P1 receptors


    1 Kegg Pathway  (Kegg details for ADORA3):
        Neuroactive ligand-receptor interaction


    ADORA3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ADORA3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADORA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADORA3 (P337653 ENSP000003587304) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADRA2BENSP000003872814STRING: ENSP00000387281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway ----
    GO:0002553histamine secretion by mast cell IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006954inflammatory response TAS9164961
    GO:0007165signal transduction TAS8399349

    ADORA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADORA3
      Browse compounds at ApexBio 

    Compounds for ADORA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 1220 Highly potent, selective hA3 antagonist [183721-15-5]
    IB-MECAA3 selective agonist[152918-18-8]
    VUF 5574 Potent, selective hA3 antagonist [280570-45-8]
    MRS 1334 Potent, highly selective hA3 antagonist [192053-05-7]
    2-Cl-IB-MECAHighly selective A3 agonist[163042-96-4]

    1 HMDB Compound for ADORA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--

    2 DrugBank Compounds for ADORA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 16339914 20370661 20370662 17438146 11752352 17442976 20136829
    AminophyllineAminophyllin (see all 4)317-34-0targetantagonist9806324

    Selected IUPHAR Ligands for ADORA3 (A3 receptor) (see all 91)    About this table
    LigandTypeActionAffinityPubmed IDs
    KF26777
    AntagonistAntagonist9.712063073
    MRS3558
    AgonistAgonist9.5416518376
    MRE 3008F20
    AntagonistAntagonist9 - 9.510779381 16219300 16518376
    (R,S)-PHPNECA
    AgonistFull agonist9.412109910
    PSB-10
    AntagonistAntagonist9.3612139454
    2-phenylethylyl-adenosine derivative
    AgonistAgonist9.3619839592
    MRE 3010F20
    AntagonistAntagonist9.310779381
    IB-MECA
    AgonistFull agonist8.7 - 9.29459566 10779381 11705449
    MRS1220
    AntagonistAntagonist8.2 - 9.29364471 11226132 8863790 16553647
    [3H]MRE 3008F20
    AntagonistAntagonist9.110779381 10698437

    Selected Novoseek inferred chemical compound relationships for ADORA3 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4'-thioadenosine 92.5 1 18776543 (1)
    cf 101 92.3 16 17101059 (5), 15720820 (2), 14562031 (2), 18050382 (2) (see all 8)
    mrs1191 89.9 1 18059189 (1)
    2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide 88.7 4 18059189 (2)
    vuf 5574 85.5 1 16088125 (1)
    mrs 1220 84.9 1 15147729 (1)
    pacpx 69.9 2 9722021 (1)
    ribose 69.7 7 16305531 (3), 15104242 (1), 17067963 (1), 18038898 (1) (see all 5)
    dpcpx 69.6 1 16026998 (1)
    5'-n-ethylcarboxamidoadenosine 68 4 9351976 (1), 9380026 (1), 10494877 (1)



    ADORA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADORA3 gene (3 alternative transcripts): 
    NM_000677.3  NM_001081976.1  NM_020683.6  

    Unigene Cluster for ADORA3:

    Adenosine A3 receptor
    Hs.281342  [show with all ESTs]
    Unigene Representative Sequence: NM_000677
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414219 ENST00000369716(uc001ebf.3) ENST00000369717(uc001ebg.4)
    ENST00000443498 ENST00000472933 ENST00000442484 ENST00000463993 ENST00000241356(uc001ebh.4)
    ENST00000495493 ENST00000486342

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    SwitchGear 3'UTR luciferase reporter plasmidADORA3 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADORA3
      QuantiTect SYBR Green Assays in human, mouse, rat ADORA3
      QuantiFast Probe-based Assays in human, mouse, rat ADORA3

    Additional mRNA sequence: 

    AK313095.1 AY136749.1 AY358644.1 BC029831.1 BC041707.1 BC064411.1 JN855714.1 L20463.1 
    L22607.1 X76981.1 

    10 DOTS entries:

    DT.309636  DT.95167280  DT.410375  DT.95167281  DT.92471263  DT.95167272  DT.91680433  DT.97773741 
    DT.121382674  DT.121382732 

    Selected AceView cDNA sequences (see all 87):

    BX093971 AA974687 AI198874 CA843261 AI129184 BC064411 AY358644 BG205723 
    CD013875 BQ575272 BC041707 BF432324 CK903038 NM_020683 CF456186 BI822569 
    BI828255 BG198979 BG186580 BE044135 AA313084 BI463020 NM_000677 CD104512 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:              -     -     -     -     -     -     -     -     -     -                 -     -     -                             -                       -   
    SP2:                                            -     -     -     -     -                 -     -     -                             -                       -   
    SP3:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -                       -   
    SP4:                                                                                                  -                             -                       -   
    SP5:                                                                                      -     -     -     -                       -                           

    ExUns: 10c ^ 11a · 11b
    SP1:  -               
    SP2:  -               
    SP3:  -               
    SP4:  -               
    SP5:                  


    ECgene alternative splicing isoforms for ADORA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADORA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATTGTGGA
    ADORA3 Expression
    About this image


    ADORA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Testis (Reproductive System)
    ADORA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADORA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.281342
        Pathway & Disease-focused RT2 Profiler PCR Array including ADORA3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADORA3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora31 , 5 adenosine A3 receptor1, 5 78.9(n)1
    74.05(a)1
      3 (46.45 cM)5
    115421  NM_009631.41  NP_033761.21 
     1058708585 
    chicken
    (Gallus gallus)
    Aves ADORA31 adenosine A3 receptor 62.9(n)
    58.06(a)
      373956  NM_204151.1  NP_989482.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017346291 adenosine receptor A3-like 61.04(n)
    57.77(a)
      101734629  XM_004910728.1  XP_004910785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5714101 adenosine receptor A1-like 56.41(n)
    50.17(a)
      571410  XM_694994.2  XP_700086.1 


    ENSEMBL Gene Tree for ADORA3 (if available)
    TreeFam Gene Tree for ADORA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADORA3 gene
    4 SIMAP similar genes for ADORA3 using alignment to 5 protein entries:     AA3RB_HUMAN (see all proteins):
    ADORA1    ADORA2A    ADORA2B    CD300E

    ADORA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADORA3 (see all 1873)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357554
    A colorectal cancer sample4--see VAR_0357552 A T mis40--------
    rs1137354901,2
    C,F--109896952(+) GATGAC/TGGCAG 2 -- ds50012Minor allele frequency- T:0.21CSA WA 119
    rs39048381,2
    H--109896963(+) CACAGA/TCAGTG 2 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs741095951,2
    C,F--109896971(+) GTGAGT/GGGGAG 2 -- ds50012Minor allele frequency- G:0.22WA 120
    rs781648501,2
    F--109896989(+) GAATTC/TCCAGA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1867925421,2
    --109897003(+) AGCAGC/GAGAGA 2 -- ds50010--------
    rs1498954731,2
    --109897019(+) TATGGA/GGAGAG 2 -- ds50010--------
    rs1439568151,2
    --109897034(+) TGTAGA/CTATGC 2 -- ds50010--------
    rs1919169481,2
    --109897057(+) AGAGTA/GTTGGT 2 -- ds50010--------
    rs1845857731,2
    --109897227(+) TCCCAC/TTAAGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADORA3 (112025970 - 112106597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADORA3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1773706CNV Deletion17803354
    esv2716263CNV Deletion23290073
    esv2716229CNV Deletion23290073
    esv2716274CNV Deletion23290073
    esv2716252CNV Deletion23290073
    esv2716240CNV Deletion23290073
    esv2669491CNV Deletion23128226
    nsv2410CNV Insertion18451855
    esv1401225CNV Insertion17803354
    esv270092CNV Insertion20981092

    Human Gene Mutation Database (HGMD): ADORA3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADORA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600445    OMIM disorders: --

    Selected diseases for ADORA3 (see all 33):    
    About MalaCards
    ischemia    brain ischemia    urticaria    thyroiditis
    astrocytoma    glaucoma    osteoporosis    arthritis
    rheumatoid arthritis    thyroid cancer    coronary heart disease    asthma
    cerebritis    sepsis    psoriasis    crohn's disease
    melanoma    breast and colorectal cancer    parkinson's disease    hypoxia


    ADORA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADORA3 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudoexfoliation syndrome 47.2 1 15914619 (1)
    cerebral ischemia 43.7 3 10078988 (1), 10668416 (1), 7821362 (1)
    ischemia 41.4 5 9988118 (1), 12970092 (1), 10355598 (1), 15922260 (1) (see all 5)
    brain ischemia 25.5 1 11462807 (1)
    glaucoma 24.9 3 15203160 (1), 15914619 (1), 15830199 (1)
    aqueous humor 21.2 3 15914619 (1), 15830199 (1)
    effects cardiovascular 14.8 2 9380026 (1)
    rheumatoid arthritis 13.3 11 17216675 (2), 18050382 (2), 16305531 (1), 17922624 (1) (see all 8)
    arthritis 12.4 7 17101059 (1), 17216675 (1), 19639281 (1), 17922624 (1) (see all 5)
    asthma 11.8 4 16300745 (1), 20190146 (1)

    Genetic Association Database (GAD): ADORA3
    Human Genome Epidemiology (HuGE) Navigator: ADORA3 (11 documents)

    Export disorders for ADORA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADORA3 gene, integrated from 10 sources (see all 218):
    (articles sorted by number of sources associating them with ADORA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human A3 adenosine receptor. (PubMed id 8234299)1, 2, 9 Salvatore C.A.... Johnson R.G. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PubMed id 8399349)1, 2, 9 Sajjadi F.G. and Firestein G.S. (Biochim. Biophys. Acta 1993)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Functional variability of the adenosine A3 receptor (ADORA3) gene polymorphism in aspirin-induced urticaria. (PubMed id 20716228)1, 4 Kim S.H....Park H.S. (Br. J. Dermatol. 2010)
    7. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4 Kim S.H....Park H.S. (Respir Med 2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    9. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    10. Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy. (PubMed id 17728764)1, 4 Tang Z....Feldman A.M. (Clin. Pharmacol. Ther. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 140 HGNC: 268 AceView: ADORA3 Ensembl:ENSG00000121933 euGenes: HUgn140
    ECgene: ADORA3 Kegg: 140 H-InvDB: ADORA3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADORA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADORA3 gene:
    Search GeneIP for patents involving ADORA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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