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Aliases for ADORA3 Gene

Aliases for ADORA3 Gene

  • Adenosine A3 Receptor 2 3 5
  • A3AR 3

External Ids for ADORA3 Gene

Previous GeneCards Identifiers for ADORA3 Gene

  • GC01M112458
  • GC01M110913
  • GC01M111144
  • GC01M111340
  • GC01M111326
  • GC01M111739
  • GC01M111827
  • GC01M112025
  • GC01M109897
  • GC01M111484

Summaries for ADORA3 Gene

Entrez Gene Summary for ADORA3 Gene

  • This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

GeneCards Summary for ADORA3 Gene

ADORA3 (Adenosine A3 Receptor) is a Protein Coding gene. Diseases associated with ADORA3 include Ischemia. Among its related pathways are Peptide ligand-binding receptors and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot for ADORA3 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

Tocris Summary for ADORA3 Gene

  • The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney and heart.

Gene Wiki entry for ADORA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA3 Gene

Genomics for ADORA3 Gene

Regulatory Elements for ADORA3 Gene

Enhancers for ADORA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADORA3 on UCSC Golden Path with GeneCards custom track

Promoters for ADORA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADORA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADORA3 Gene

Chromosome:
1
Start:
111,499,429 bp from pter
End:
111,504,121 bp from pter
Size:
4,693 bases
Orientation:
Minus strand

Genomic View for ADORA3 Gene

Genes around ADORA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA3 Gene

Proteins for ADORA3 Gene

  • Protein details for ADORA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMS8-AA3R_HUMAN
    Recommended name:
    Adenosine receptor A3
    Protein Accession:
    P0DMS8
    Secondary Accessions:
    • A2A3P4
    • P33765
    • Q6UWU0
    • Q9BYZ1

    Protein attributes for ADORA3 Gene

    Size:
    318 amino acids
    Molecular mass:
    36185 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADORA3 Gene

    Alternative splice isoforms for ADORA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADORA3 Gene

Proteomics data for ADORA3 Gene at MOPED

Post-translational modifications for ADORA3 Gene

  • Phosphorylation on Ser-317 may be crucial for rapid desensitization.
  • Glycosylation at Asn 3, Asn 4, and Asn 12
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA3 Gene

No data available for DME Specific Peptides for ADORA3 Gene

Domains & Families for ADORA3 Gene

Protein Domains for ADORA3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DMS8

UniProtKB/Swiss-Prot:

AA3R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA3: view

Function for ADORA3 Gene

Molecular function for ADORA3 Gene

GENATLAS Biochemistry:
adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
genes like me logo Genes that share phenotypes with ADORA3: view

Animal Models for ADORA3 Gene

MGI Knock Outs for ADORA3:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA3 Gene

Localization for ADORA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA3 Gene COMPARTMENTS Subcellular localization image for ADORA3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ADORA3 Gene

Drugs & Compounds for ADORA3 Gene

(117) Drugs for ADORA3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist, agonist, Target 384
Theophylline Approved Pharma Antagonist, antagonist 59
Aminophylline Approved Pharma Target, antagonist 23
Nicardipine Approved Pharma Antagonist, blocker 29
Regadenoson Approved Pharma Agonist 62

(37) Additional Compounds for ADORA3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MRS 1220
183721-15-5
(R)-niguldipine
Antagonist
SCH4421416
Antagonist
XAC
Antagonist
2-Cl-IB-MECA
163042-96-4

(5) Tocris Compounds for ADORA3 Gene

Compound Action Cas Number
2-Cl-IB-MECA Highly selective A3 agonist 163042-96-4
HEMADO High affinity selective A3 agonist 403842-38-6
IB-MECA A3 selective agonist 152918-18-8
MRS 1220 Highly potent, selective hA3 antagonist 183721-15-5
MRS 5698 High affinity and selective A3 adenosine receptor agonist 1377273-00-1

(6) ApexBio Compounds for ADORA3 Gene

Compound Action Cas Number
Adenine HCl Adenine receptor agonist 2922-28-3
CGS 21680 HCl A2 adenosine receptor agonist 124431-80-7
Istradefylline (KW-6002) Selective A2A receptor antagonist 155270-99-8
Preladenant Adenosine A2A receptor antagonist 377727-87-2
Ticlopidine HCl 53885-35-1
Valsartan Angiotensin II AT1 receptor antagonist 137862-53-4
genes like me logo Genes that share compounds with ADORA3: view

Drug Products

Transcripts for ADORA3 Gene

Unigene Clusters for ADORA3 Gene

Adenosine A3 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 10c ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ADORA3 Gene

GeneLoc Exon Structure for
ADORA3
ECgene alternative splicing isoforms for
ADORA3

Expression for ADORA3 Gene

mRNA expression in normal human tissues for ADORA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.5).

Protein differential expression in normal tissues from HIPED for ADORA3 Gene

This gene is overexpressed in Ovary (35.0) and Testis (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADORA3 Gene



SOURCE GeneReport for Unigene cluster for ADORA3 Gene Hs.281342

genes like me logo Genes that share expression patterns with ADORA3: view

Protein tissue co-expression partners for ADORA3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA3 Gene

Orthologs for ADORA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADORA3 35
  • 87.28 (n)
  • 88.01 (a)
dog
(Canis familiaris)
Mammalia ADORA3 35
  • 87.69 (n)
  • 88.22 (a)
mouse
(Mus musculus)
Mammalia Adora3 35
  • 78.9 (n)
  • 74.05 (a)
Adora3 16
chimpanzee
(Pan troglodytes)
Mammalia ADORA3 35
  • 99.79 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ADORA3 35
  • 62.9 (n)
  • 58.06 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734629 35
  • 61.04 (n)
  • 57.77 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571410 35
  • 56.41 (n)
  • 50.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 32 (a)
Species with no ortholog for ADORA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADORA3 Gene

ENSEMBL:
Gene Tree for ADORA3 (if available)
TreeFam:
Gene Tree for ADORA3 (if available)

Paralogs for ADORA3 Gene

Paralogs for ADORA3 Gene

(4) SIMAP similar genes for ADORA3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADORA3: view

Variants for ADORA3 Gene

Sequence variations from dbSNP and Humsavar for ADORA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035755 A colorectal cancer sample
VAR_049366 -
VAR_049367 -

Structural Variations from Database of Genomic Variants (DGV) for ADORA3 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
nsv2410 CNV Insertion 18451855
esv270092 CNV Insertion 20981092
nsv872150 CNV Loss 21882294
esv1401225 CNV Insertion 17803354
nsv2421 CNV Loss 18451855
esv2716229 CNV Deletion 23290073
esv2716240 CNV Deletion 23290073
esv2669491 CNV Deletion 23128226
esv2716252 CNV Deletion 23290073
esv2716263 CNV Deletion 23290073
esv2716274 CNV Deletion 23290073
esv1773706 CNV Deletion 17803354

Variation tolerance for ADORA3 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADORA3 Gene

Human Gene Mutation Database (HGMD)
ADORA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA3 Gene

Disorders for ADORA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADORA3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ischemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADORA3

Genetic Association Database (GAD)
ADORA3
Human Genome Epidemiology (HuGE) Navigator
ADORA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADORA3
genes like me logo Genes that share disorders with ADORA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADORA3 Gene

Publications for ADORA3 Gene

  1. Molecular cloning and characterization of the human A3 adenosine receptor. (PMID: 8234299) Salvatore C.A. … Johnson R.G. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23 67
  2. Activation of mast cells by trimeric G protein Gi3; coupling to the A3 adenosine receptor directly and upon T cell contact. (PMID: 20190146) Baram D. … Sagi-Eisenberg R. (J. Immunol. 2010) 3 23
  3. The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. (PMID: 20136829) Buenestado A. … Devillier P. (Br. J. Pharmacol. 2010) 25 26
  4. A1 receptors ligands: past, present and future trends. (PMID: 20370661) Schenone S. … Botta M. (Curr Top Med Chem 2010) 25 26
  5. Adenosine receptors: what we know and what we are learning. (PMID: 20370662) Trincavelli M.L. … Martini C. (Curr Top Med Chem 2010) 25 26

Products for ADORA3 Gene

Sources for ADORA3 Gene

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