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Aliases for ADORA3 Gene

Aliases for ADORA3 Gene

  • Adenosine A3 Receptor 2 3
  • Adenosine Receptor A3 3
  • A3AR 3

External Ids for ADORA3 Gene

Previous GeneCards Identifiers for ADORA3 Gene

  • GC01M112458
  • GC01M110913
  • GC01M111144
  • GC01M111340
  • GC01M111326
  • GC01M111739
  • GC01M111827
  • GC01M112025
  • GC01M109897

Summaries for ADORA3 Gene

Entrez Gene Summary for ADORA3 Gene

  • This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

GeneCards Summary for ADORA3 Gene

ADORA3 (Adenosine A3 Receptor) is a Protein Coding gene. Diseases associated with ADORA3 include ischemia and brain ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled adenosine receptor activity.

UniProtKB/Swiss-Prot for ADORA3 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

Tocris Summary for ADORA3 Gene

  • The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion. The human A3 receptor gene is localized on chromosome 1 (1p21-p13).

Gene Wiki entry for ADORA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA3 Gene

Genomics for ADORA3 Gene

Regulatory Elements for ADORA3 Gene

Genomic Location for ADORA3 Gene

Start:
111,483,348 bp from pter
End:
111,563,977 bp from pter
Size:
80,630 bases
Orientation:
Minus strand

Genomic View for ADORA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA3 Gene

Proteins for ADORA3 Gene

  • Protein details for ADORA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMS8-AA3R_HUMAN
    Recommended name:
    Adenosine receptor A3
    Protein Accession:
    P0DMS8
    Secondary Accessions:
    • A2A3P4
    • P33765
    • Q6UWU0
    • Q9BYZ1

    Protein attributes for ADORA3 Gene

    Size:
    318 amino acids
    Molecular mass:
    36185 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADORA3 Gene

neXtProt entry for ADORA3 Gene

Proteomics data for ADORA3 Gene at MOPED

Post-translational modifications for ADORA3 Gene

  • Phosphorylation on Ser-317 may be crucial for rapid desensitization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADORA3 Gene

Antibody Products

No data available for DME Specific Peptides for ADORA3 Gene

Domains for ADORA3 Gene

Gene Families for ADORA3 Gene

HGNC:
  • ADORA :GPCR / Class A : Adenosine receptors
  • VSET :Immunoglobulin superfamily / V-set domain containing
IUPHAR :

Protein Domains for ADORA3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DMS8

UniProtKB/Swiss-Prot:

AA3R_HUMAN :
  • P0DMS8
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA3: view

Function for ADORA3 Gene

Molecular function for ADORA3 Gene

GENATLAS Biochemistry: adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

Gene Ontology (GO) - Molecular Function for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with ADORA3: view
genes like me logo Genes that share phenotypes with ADORA3: view

Animal Models for ADORA3 Gene

MGI Knock Outs for ADORA3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADORA3 Gene

Localization for ADORA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA3 Gene COMPARTMENTS Subcellular localization image for ADORA3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane --
GO:0016021 integral component of membrane IEA --
GO:0042629 mast cell granule --
genes like me logo Genes that share ontologies with ADORA3: view

Pathways for ADORA3 Gene

genes like me logo Genes that share pathways with ADORA3: view

Pathways by source for ADORA3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ADORA3 Gene

Gene Ontology (GO) - Biological Process for ADORA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002553 histamine secretion by mast cell --
GO:0002687 positive regulation of leukocyte migration --
GO:0006954 inflammatory response --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with ADORA3: view

Compounds for ADORA3 Gene

(5) Tocris Compounds for ADORA3 Gene

Compound Action Cas Number
2-Cl-IB-MECA Highly selective A3 agonist [163042-96-4]
HEMADO High affinity selective A3 agonist [403842-38-6]
IB-MECA A3 selective agonist [152918-18-8]
MRE 3008F20 Highly potent and selective adenosine A3 receptor antagonist [252979-43-4]
MRS 1220 Highly potent, selective hA3 antagonist [183721-15-5]

(1) HMDB Compounds for ADORA3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
58-61-7

(2) Drugbank Compounds for ADORA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine
  • 2'-Deoxyadenosine
58-61-7 target agonist
Aminophylline
  • Aminophyllin
317-34-0 target antagonist

(91) IUPHAR Ligand for ADORA3 Gene

Ligand Type Action Affinity Pubmed IDs
SCH4421416 Antagonist Antagonist 10.3
CGS 15943 Antagonist Antagonist 9.4
2-phenylethylyl-adenosine derivative Agonist Agonist 9.36
MRE 3010F20 Antagonist Antagonist 9.3
apadenoson Agonist Agonist 9.3
MRS1093 Antagonist Antagonist 9.2
SCH 58261 Antagonist Antagonist 9.2
[3H]MRE 3008F20 Antagonist Antagonist 9.1
[125I]AB-MECA Agonist Full agonist 9.1
ZM-241385 Antagonist Antagonist 9.1
preladenant Antagonist Antagonist 9.05
[3H]HEMADO Agonist Full agonist 9
XAC Antagonist Antagonist 9
BIIB014 Antagonist Antagonist 8.89
NECA Agonist Full agonist 8.7
(R,S)-PHPNECA Agonist Full agonist 8.5
MRS1177 Antagonist Antagonist 8.5
VUF5574 Antagonist Antagonist 8.39
2-hexynyl-NECA Agonist Full agonist 8.3
[3H]PSB-11 Antagonist Antagonist 8.3
MSX-2 Antagonist Antagonist 8.27
ST-1535 Antagonist Antagonist 8.18
MRS1186 Antagonist Antagonist 8.1
MRS1505 Antagonist Antagonist 8.1
CGS 21680 Agonist Full agonist 8.1
I-ABA Agonist Full agonist 8
istradefylline Antagonist Antagonist 7.92
[125I]APNEA Agonist Full agonist 7.8
VUF8504 Antagonist Antagonist 7.8
[3H]NECA Agonist Full agonist 7.7
MRS1476 Antagonist Antagonist 7.7
MRS1486 Antagonist Antagonist 7.5
I-ABOPX Antagonist Antagonist 7.4
BW-A1433 Antagonist Antagonist 7.3
DPCPX Antagonist Antagonist 7.2
MRS1097 Antagonist Antagonist 7
rolofylline Antagonist Antagonist 6.97
MRE 3008F20 Antagonist Antagonist 6.8
MPC-MECA Agonist Full agonist 6.8
LUF5981 Antagonist Antagonist 6.71
VUF8507 Antagonist Antagonist 6.7
TCPA Agonist Agonist 6.68
binodenoson Agonist Agonist 6.57
regadenoson Agonist Agonist 6.54
MRS1220 Antagonist Antagonist 6.5
SLV320 Antagonist Antagonist 6.4
KF26777 Antagonist Antagonist 6.33
IB-MECA Agonist Full agonist 6.3
MRS1754 Antagonist Antagonist 6.3
PENECA Agonist Full agonist 6.2
(R)-PIA Agonist Full agonist 6.2
MRS1067 Antagonist Antagonist 6.2
ATL802 Antagonist Antagonist 6.18
cyclopentyladenosine Agonist Full agonist 6.1
PSB36 Antagonist Antagonist 6.01
MRE 2029F20 Antagonist Antagonist 6
LAS38096 Antagonist Antagonist 6
galangin Antagonist Antagonist 6
HEMADO Agonist Agonist 5.92
N(6)-cyclohexyladenosine Agonist Full agonist 5.9
PSB-11 Antagonist Antagonist 5.89
FK-453 Antagonist Antagonist 5.89
theophylline Antagonist Antagonist 5.8
(R)-niguldipine Antagonist Antagonist 5.7
MRS3558 Agonist Agonist 5.63
CCPA Agonist Full agonist 5.6
PSB-10 Antagonist Antagonist 5.57
MRS1042 Antagonist Antagonist 5.5
MRS1041 Antagonist Antagonist 5.5
nicardipine Antagonist Antagonist 5.5
flavone Antagonist Antagonist 5.5
CVT-6883 Antagonist Antagonist 5.48
MRS1523 Antagonist Antagonist 5.44
AB-MECA Agonist Full agonist 5.4
Cl-IB-MECA Agonist Agonist 5.27
MRS928 Antagonist Antagonist 5.2
tonapofylline Antagonist Antagonist 5.19
CP608,039 Agonist Agonist 5.14
(S)-PIA Agonist Full agonist 5.1
MRS5151 Agonist Agonist 5
MRS1191 Antagonist Antagonist 5
GS9667 Agonist Agonist 5
PSB603 Antagonist Antagonist 5
PSB1115 Antagonist Antagonist 5
Bay60-6583 Agonist Agonist 5
sakuranetin Antagonist Antagonist 4.4
visnagin Antagonist Antagonist 4.4
MRS1088 Antagonist Antagonist 4.3
flavanone Antagonist Antagonist 4.3
adenosine Channel blocker None 3.2
caffeine Activator None

(50) Novoseek inferred chemical compound relationships for ADORA3 Gene

Compound -log(P) Hits PubMed IDs
4-thioadenosine 92.5 1
cf 101 92.3 15
mrs1191 89.9 1
2-chloro-n(6)-(3-iodobenzyl)adenosine-5-n-methyluronamide 88.7 2
vuf 5574 85.5 1
genes like me logo Genes that share compounds with ADORA3: view

Transcripts for ADORA3 Gene

Unigene Clusters for ADORA3 Gene

Adenosine A3 receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 10c ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ADORA3 Gene

GeneLoc Exon Structure for
ADORA3
ECgene alternative splicing isoforms for
ADORA3

Expression for ADORA3 Gene

mRNA expression in normal human tissues for ADORA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADORA3 Gene

SOURCE GeneReport for Unigene cluster for ADORA3 Gene Hs.281342

genes like me logo Genes that share expressions with ADORA3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA3 Gene

Orthologs for ADORA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADORA3 35
  • 99.79 (n)
  • 100 (a)
ADORA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADORA3 35
  • 87.28 (n)
  • 88.01 (a)
ADORA3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADORA3 35
  • 87.69 (n)
  • 88.22 (a)
ADORA3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora3 35
  • 78.9 (n)
  • 74.05 (a)
Adora3 16
Adora3 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADORA3 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADORA3 35
  • 62.9 (n)
  • 58.06 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734629 35
  • 61.04 (n)
  • 57.77 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571410 35
  • 56.41 (n)
  • 50.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 32 (a)
Species with no ortholog for ADORA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADORA3 Gene

ENSEMBL:
Gene Tree for ADORA3 (if available)
TreeFam:
Gene Tree for ADORA3 (if available)

Paralogs for ADORA3 Gene

Selected SIMAP similar genes for ADORA3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADORA3: view

No data available for Paralogs for ADORA3 Gene

Variants for ADORA3 Gene

Sequence variations from dbSNP and Humsavar for ADORA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs923 -- 111,499,761(+) GACAA(A/G)GGAAA utr-variant-3-prime, intron-variant
rs3393 -- 111,499,527(-) CCTAG(A/G)AGATG utr-variant-3-prime, intron-variant
rs3394 -- 111,499,509(+) TATTT(C/T)TTCTG utr-variant-3-prime, intron-variant
rs7737 -- 111,483,530(-) ACGGC(A/G)GTAGT utr-variant-3-prime
rs9025 -- 111,483,576(+) GAGGG(A/T)CCTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADORA3 Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV Loss 19166990
nsv2410 CNV Insertion 18451855
esv270092 CNV Insertion 20981092
nsv872150 CNV Loss 21882294
esv1401225 CNV Insertion 17803354
nsv2421 CNV Loss 18451855
esv2716229 CNV Deletion 23290073
esv2716240 CNV Deletion 23290073
esv2669491 CNV Deletion 23128226
esv2716252 CNV Deletion 23290073
esv2716263 CNV Deletion 23290073
esv2716274 CNV Deletion 23290073
esv1773706 CNV Deletion 17803354

Relevant External Links for ADORA3 Gene

HapMap Linkage Disequilibrium report
ADORA3
Human Gene Mutation Database (HGMD)
ADORA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA3 Gene

Disorders for ADORA3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ADORA3 Gene including...

Search for ADORA3 Gene in MalaCards »

(22) Novoseek inferred disease relationships for ADORA3 Gene

Disease -log(P) Hits PubMed IDs
pseudoexfoliation syndrome 47.2 1
cerebral ischemia 43.7 3
ischemia 41.4 5
brain ischemia 25.5 1
glaucoma 24.9 3

Relevant External Links for ADORA3

Genetic Association Database (GAD)
ADORA3
Human Genome Epidemiology (HuGE) Navigator
ADORA3
genes like me logo Genes that share disorders with ADORA3: view

No data available for UniProtKB/Swiss-Prot for ADORA3 Gene

Publications for ADORA3 Gene

  1. cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PMID: 8399349) Sajjadi F.G. … Firestein G.S. (Biochim. Biophys. Acta 1993) 3 4 23
  2. Molecular cloning and characterization of the human A3 adenosine receptor. (PMID: 8234299) Salvatore C.A. … Johnson R.G. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  3. Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. (PMID: 9293494) Atkinson M.R. … Schofield P.R. (Neurosci. Res. 1997) 3 23
  4. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. (PMID: 9380026) Palmer T.M. … Stiles G.L. (Mol. Pharmacol. 1997) 3 23
  5. A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. (PMID: 12435805) Trincavelli M.L. … Martini C. (Mol. Pharmacol. 2002) 3 23

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