Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADORA3 Gene

protein-coding   GIFtS: 70
GCID: GC01M112025

Adenosine A3 Receptor

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosine A3 Receptor1 2
A3AR2
AD0262
Adenosine Receptor A32
bA552M11.52

External Ids:    HGNC: 2681   Entrez Gene: 1402   Ensembl: ENSG000001219337   OMIM: 6004455   UniProtKB: Q6P2N63   
UniProtKB: P337653   

Export aliases for ADORA3 gene to outside databases

Previous GC identifers: GC01M112458 GC01M110913 GC01M111144 GC01M111340 GC01M111326 GC01M111739 GC01M111827 GC01M109897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADORA3 Gene:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled
receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The
receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is
involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been
implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation
and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ADORA3 Gene: 
ADORA3 (adenosine A3 receptor) is a protein-coding gene. Diseases associated with ADORA3 include ischemia, and brain ischemia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6 (see all)
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl
cyclase. Possible role in reproduction

summary for ADORA3 Gene:
The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that
also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats,
with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine
A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion.
The human A3 receptor gene is localized on chromosome 1 (1p21-p13).

Gene Wiki entry for ADORA3 (Adenosine A3 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADORA3 gene promoter:
         CREB   Elk-1   FOXF2   FOXO4   deltaCREB   PPAR-gamma2   Evi-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADORA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADORA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

ADORA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M112025:  view genomic region     (about GC identifiers)

Start:
112,025,970 bp from pter      End:
112,106,597 bp from pter
Size:
80,628 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6 (See protein sequence)
Recommended Name: Protein ADORA3, isoform 3  
Size: 266 amino acids; 30327 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH41707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH64411.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW56500.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5QNY7
Alternative splicing: 3 isoforms:  Q6P2N6-1   P33765-1   P33765-2   

UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765 (See protein sequence)

Recommended Name: Adenosine receptor A3  
Size: 318 amino acids; 36185 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for ADORA3:
1OEA (3D)        1R7N (3D)    
Secondary accessions: A2A3P4 Q6UWU0 Q9BYZ1
Alternative splicing: 3 isoforms:  P33765-1   P33765-2   Q6P2N6-1   

Explore the universe of human proteins at neXtProt for ADORA3: NX_P33765

Explore proteomics data for ADORA3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Ser-317 may be crucial for rapid desensitization (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33765

  • ADORA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADORA3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000668.1  NP_001075445.1  NP_065734.5  

    ENSEMBL proteins: 
     ENSP00000415646   ENSP00000358730   ENSP00000358731   ENSP00000398770   ENSP00000406102  
     ENSP00000241356  
    Reactome Protein details: P33765
    Human Recombinant Protein Products for ADORA3: 
    EMD Millipore Purified and/or Recombinant ADORA3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADORA3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADORA3
    GenScript Custom Purified and Recombinant Proteins Services for ADORA3
    Novus Biologicals ADORA3 Protein
    Novus Biologicals ADORA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADORA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    ADORA3 for ontologies           About GeneDecksing



    ADORA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADORA3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADORA3
    GenScript Custom Superior Antibodies Services for ADORA3
    Novus Biologicals ADORA3 Antibodies
    Abcam antibodies for ADORA3 (Q6P2N6, P33765)
    Cloud-Clone Corp. Antibodies for ADORA3 
    ThermoFisher Antibodies for ADORA3
    LSBio Antibodies in human, mouse, rat for ADORA3 

    Assay Products for ADORA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADORA3
    Browse R&D Systems for biochemical assays
    GenScript ADORA3-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADORA3 
    Cloud-Clone Corp. CLIAs for ADORA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADORA: GPCR / Class A : Adenosine receptors
    VSET: Immunoglobulin superfamily / V-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: A3 receptor 
    Adenosine receptors

    5 InterPro protein domains:
     IPR001634 Adenosn_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR013783 Ig-like_fold
     IPR000466 Adeno_A3_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q6P2N6
    Graphical View of Domain Structure for InterPro Entry P33765

    ProtoNet protein and cluster: Q6P2N6

    UniProtKB/Swiss-Prot: AA3RB_HUMAN, Q6P2N6
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: AA3R_HUMAN, P33765
    Similarity: Belongs to the G-protein coupled receptor 1 family


    ADORA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
    UniProtKB/Swiss-Prot Summary: AA3RB_HUMAN, Q6P2N6 (see all)
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl
    cyclase. Possible role in reproduction

         Genatlas biochemistry entry for ADORA3:
    adenosine receptor A3,widely expressed,most abundant in brain and some endocrine tissues,G protein coupled
    receptor superfamily,activating adenylate cyclase

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
         
    ADORA3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ADORA3:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adora3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     no phenotypic analysis  renal/urinary system  respiratory system  vision/eye 

    ADORA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adora3tm1Jbsn for ADORA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADORA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADORA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADORA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADORA3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADORA3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADORA3:
    hsa-miR-4291 hsa-miR-2278 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidADORA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADORA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADORA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADORA3
    Sirion Biotech Customized adenovirus for overexpression of ADORA3

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of ADORA3
    OriGene clones in human, mouse for ADORA3 (see all 19)
    OriGene ORF clones in mouse, rat for ADORA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADORA3 (NM_001081976)
    Sino Biological Human cDNA Clone for ADORA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADORA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3
    Sirion Biotech Customized lentivirus for stable overexpression of ADORA3 
                         Customized lentivirus expression plasmids for stable overexpression of ADORA3 

    Cell Line
    Products:
         
    GenScript ADORA3-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for ADORA3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADORA3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors0.75
    Adenosine P1 receptors0.36
    Nucleotide GPCRs0.59
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    5Development A3 receptor signaling
    Development A3 receptor signaling0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ADORA3
        Signal transduction IP3 signaling
    Development A3 receptor signaling


    2 GeneGo (Thomson Reuters) Pathways for ADORA3
        Development A3 receptor signaling
    Signal transduction IP3 signaling

    3 BioSystems Pathways for ADORA3
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs


    5/8        Reactome Pathways for ADORA3 (see all 8)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    Adenosine P1 receptors


    1         Kegg Pathway  (Kegg details for ADORA3):
        Neuroactive ligand-receptor interaction


    ADORA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADORA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/149 Interacting proteins for ADORA3 (P337653 ENSP000003587304) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADORA1ENSP000003085494STRING: ENSP00000308549
    AGTR2ENSP000003609734STRING: ENSP00000360973
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway ----
    GO:0002553histamine secretion by mast cell IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006954inflammatory response TAS9164961
    GO:0007165signal transduction TAS8399349

    ADORA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADORA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ADORA3

    Compounds for ADORA3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 1220 Highly potent, selective hA3 antagonist [183721-15-5]
    IB-MECAA3 selective agonist[152918-18-8]
    VUF 5574 Potent, selective hA3 antagonist [280570-45-8]
    MRS 1334 Potent, highly selective hA3 antagonist [192053-05-7]
    2-Cl-IB-MECAHighly selective A3 agonist[163042-96-4]

    1 HMDB Compound for ADORA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--

    2 DrugBank Compounds for ADORA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 16339914 20370661 20370662 17438146 11752352 17442976 20136829
    AminophyllineAminophyllin (see all 4)317-34-0targetantagonist9806324

    10/91 IUPHAR Ligands for ADORA3 (A3 receptor) (see all 91)    About this table 
    LigandTypeActionAffinityPubmed IDs
    KF26777
    AntagonistAntagonist9.712063073
    MRS3558
    AgonistAgonist9.5416518376
    MRE 3008F20
    AntagonistAntagonist9 - 9.510779381 16219300 16518376
    (R,S)-PHPNECA
    AgonistFull agonist9.412109910
    PSB-10
    AntagonistAntagonist9.3612139454
    2-phenylethylyl-adenosine derivative
    AgonistAgonist9.3619839592
    MRE 3010F20
    AntagonistAntagonist9.310779381
    IB-MECA
    AgonistFull agonist8.7 - 9.29459566 10779381 11705449
    MRS1220
    AntagonistAntagonist8.2 - 9.29364471 11226132 8863790 16553647
    [3H]MRE 3008F20
    AntagonistAntagonist9.110779381 10698437

    10/50 Novoseek inferred chemical compound relationships for ADORA3 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4'-thioadenosine 92.5 1 18776543 (1)
    cf 101 92.3 16 17101059 (5), 15720820 (2), 14562031 (2), 18050382 (2) (see all 8)
    mrs1191 89.9 1 18059189 (1)
    2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide 88.7 4 18059189 (2)
    vuf 5574 85.5 1 16088125 (1)
    mrs 1220 84.9 1 15147729 (1)
    pacpx 69.9 2 9722021 (1)
    ribose 69.7 7 16305531 (3), 15104242 (1), 17067963 (1), 18038898 (1) (see all 5)
    dpcpx 69.6 1 16026998 (1)
    5'-n-ethylcarboxamidoadenosine 68 4 9351976 (1), 9380026 (1), 10494877 (1)

    Search CenterWatch for drugs/clinical trials and news about ADORA3 / AA3R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADORA3 gene (3 alternative transcripts): 
    NM_000677.3  NM_001081976.1  NM_020683.6  

    Unigene Cluster for ADORA3:

    Adenosine A3 receptor
    Hs.281342  [show with all ESTs]
    Unigene Representative Sequence: NM_000677
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414219 ENST00000369716(uc001ebf.3) ENST00000369717(uc001ebg.4)
    ENST00000443498 ENST00000472933 ENST00000442484 ENST00000463993 ENST00000241356(uc001ebh.4)
    ENST00000495493 ENST00000486342

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADORA3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADORA3:
    hsa-miR-4291 hsa-miR-2278 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidADORA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADORA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADORA3
    Clone
    Products:
         
    OriGene clones in human, mouse for ADORA3 (see all 19)
    OriGene ORF clones in mouse, rat for ADORA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADORA3 (NM_001081976)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADORA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3
    Sirion Biotech Customized lentivirus for stable overexpression of ADORA3 
                         Customized lentivirus expression plasmids for stable overexpression of ADORA3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADORA3
    OriGene qSTAR qPCR primer pairs in human, mouse for ADORA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADORA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADORA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADORA3

    Additional mRNA sequence: 

    AK313095.1 AY136749.1 AY358644.1 BC029831.1 BC041707.1 BC064411.1 JN855714.1 L20463.1 
    L22607.1 X76981.1 

    10 DOTS entries:

    DT.309636  DT.95167280  DT.410375  DT.95167281  DT.92471263  DT.95167272  DT.91680433  DT.97773741 
    DT.121382674  DT.121382732 

    24/87 AceView cDNA sequences (see all 87):

    BX093971 BQ575272 BC041707 AA974687 AI198874 BF432324 NM_020683 BC064411 
    CK903038 BI828255 AI129184 AY358644 BI822569 CA843261 BG205723 CD013875 
    CF456186 BM559463 AV717855 BG426977 X76981 CD104512 BC029831 L22607 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ADORA3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:              -     -     -     -     -     -     -     -     -     -                 -     -     -                             -                       -   
    SP2:                                            -     -     -     -     -                 -     -     -                             -                       -   
    SP3:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -                       -   
    SP4:                                                                                                  -                             -                       -   
    SP5:                                                                                      -     -     -     -                       -                           

    ExUns: 10c ^ 11a · 11b
    SP1:  -               
    SP2:  -               
    SP3:  -               
    SP4:  -               
    SP5:                  


    ECgene alternative splicing isoforms for ADORA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADORA3 expression in normal human tissues (normalized intensities)      ADORA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATTGTGGA
    ADORA3 Expression
    About this image


    ADORA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells
             blood vessel   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocyte-derived macrophage   
     
     Lung (Respiratory System)
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Epithelium (Uncategorized)
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   

    See ADORA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADORA3

    SOURCE GeneReport for Unigene cluster: Hs.281342
        SABiosciences Expression via Pathway-Focused PCR Array including ADORA3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADORA3
    OriGene qSTAR qPCR primer pairs in human, mouse for ADORA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADORA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADORA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADORA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADORA3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora31 , 5 adenosine A3 receptor1, 5 78.9(n)1
    74.05(a)1
      3 (46.45 cM)5
    115421  NM_009631.31  NP_033761.21 
     1058708585 
    chicken
    (Gallus gallus)
    Aves ADORA31 adenosine A3 receptor 64.97(n)
    60.34(a)
      373956  NM_204151.1  NP_989482.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5714101 adenosine receptor A3-like 57.7(n)
    51.72(a)
      571410  XM_694994.1  XP_700086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ador-11 Protein ADOR-1 42.4(n)
    31.62(a)
      174890  NM_001047344.1  NP_001040809.1 


    ENSEMBL Gene Tree for ADORA3 (if available)
    TreeFam Gene Tree for ADORA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADORA3 gene
    ADORA12  GPR1192  ADORA2B2  ADORA2A2  
    4 SIMAP similar genes for ADORA3 using alignment to 5 protein entries:     AA3RB_HUMAN (see all proteins):
    ADORA1    ADORA2A    ADORA2B    CD300E

    ADORA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1873 SNPs in ADORA3 are shown (see all 1873)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357554
    A colorectal cancer sample4--see VAR_0357552 A T mis40--------
    rs1137354901,2
    C,F--109896952(+) GATGAC/TGGCAG 2 -- ds50012Minor allele frequency- T:0.21CSA WA 119
    rs39048381,2
    H--109896963(+) CACAGA/TCAGTG 2 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs741095951,2
    C,F--109896971(+) GTGAGT/GGGGAG 2 -- ds50012Minor allele frequency- G:0.22WA 120
    rs781648501,2
    F--109896989(+) GAATTC/TCCAGA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1867925421,2
    --109897003(+) AGCAGC/GAGAGA 2 -- ds50010--------
    rs1498954731,2
    --109897019(+) TATGGA/GGAGAG 2 -- ds50010--------
    rs1439568151,2
    --109897034(+) TGTAGA/CTATGC 2 -- ds50010--------
    rs1919169481,2
    --109897057(+) AGAGTA/GTTGGT 2 -- ds50010--------
    rs1845857731,2
    --109897227(+) TCCCAC/TTAAGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADORA3 (112025970 - 112106597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ADORA3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1773706CNV Deletion17803354
    esv2716263CNV Deletion23290073
    esv2716229CNV Deletion23290073
    esv2716274CNV Deletion23290073
    esv2716252CNV Deletion23290073
    esv2716240CNV Deletion23290073
    esv2669491CNV Deletion23128226
    nsv2410CNV Insertion18451855
    esv1401225CNV Insertion17803354
    esv270092CNV Insertion20981092


    Human Gene Mutation Database (HGMD): ADORA3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADORA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600445    OMIM disorders: --

    20/27 diseases for ADORA3 (see all 27):    About MalaCards
    ischemia    brain ischemia    urticaria    thyroiditis
    astrocytoma    glaucoma    thyroid cancer    arthritis
    rheumatoid arthritis    coronary heart disease    cerebritis    asthma
    crohn's disease    psoriasis    melanoma    parkinson's disease
    hypoxia    hepatitis b    retinitis    breast cancer


    ADORA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/22 Novoseek inferred disease relationships for ADORA3 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudoexfoliation syndrome 47.2 1 15914619 (1)
    cerebral ischemia 43.7 3 10078988 (1), 10668416 (1), 7821362 (1)
    ischemia 41.4 5 9988118 (1), 12970092 (1), 10355598 (1), 15922260 (1) (see all 5)
    brain ischemia 25.5 1 11462807 (1)
    glaucoma 24.9 3 15203160 (1), 15914619 (1), 15830199 (1)
    aqueous humor 21.2 3 15914619 (1), 15830199 (1)
    effects cardiovascular 14.8 2 9380026 (1)
    rheumatoid arthritis 13.3 11 17216675 (2), 18050382 (2), 16305531 (1), 17922624 (1) (see all 8)
    arthritis 12.4 7 17101059 (1), 17216675 (1), 19639281 (1), 17922624 (1) (see all 5)
    asthma 11.8 4 16300745 (1), 20190146 (1)

    Genetic Association Database (GAD): ADORA3
    Human Genome Epidemiology (HuGE) Navigator: ADORA3 (11 documents)

    Export disorders for ADORA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADORA3 gene, integrated from 9 sources (see all 216):
    (articles sorted by number of sources associating them with ADORA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human A3 adenosine receptor. (PubMed id 8234299)1, 2, 9 Salvatore C.A.... Johnson R.G. (1993)
    2. cDNA cloning and sequence analysis of the human A3 adenosine receptor. (PubMed id 8399349)1, 2, 9 Sajjadi F.G. and Firestein G.S. (1993)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    6. Functional variability of the adenosine A3 receptor ( ADORA3) gene polymorphism in aspirin-induced urticaria. (PubMed id 20716228)1, 4 Kim S.H....Park H.S. (2010)
    7. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. (2009)
    8. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4 Kim S.H....Park H.S. (2008)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    10. Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy. (PubMed id 17728764)1, 4 Tang Z....Feldman A.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140 HGNC: 268 AceView: ADORA3 Ensembl:ENSG00000121933 euGenes: HUgn140
    ECgene: ADORA3 Kegg: 140 H-InvDB: ADORA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADORA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADORA3 gene:
    Search GeneIP for patents involving ADORA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADORA3
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant ADORA3 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Clones for the Expression of ADORA3
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for ADORA3 (Adenosine A3 R)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADORA3  
     OriGene qPCR primer pairs and template standards for ADORA3   OriGene Protein Over-expression Lysate for ADORA3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADORA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADORA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADORA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADORA3   OriGene Custom Protein Services for ADORA3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADORA3
     QIAGEN SeqTarget long-range PCR primers for resequencing ADORA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADORA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADORA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADORA3
     GenScript Custom Purified and Recombinant Proteins Services for ADORA3 GenScript cDNA clones with any tag delivered in your preferred vector for ADORA3
     GenScript ADORA3-overexpressing Cell Line for Assay GenScript Custom Superior Antibodies Services for ADORA3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADORA3 promoter
     Search Chromatin IP Primers for ADORA3
     RT2 qPCR Primer Assay in human, mouse, rat ADORA3
     Search GNC Networks for ADORA3
     SABiosciences PCR Arrays including human, mouse, rat ADORA3
     Tocris compounds for ADORA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ADORA3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for ADORA3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADORA3 antibodies
     ADORA3 proteins
     ADORA3 lysates
     Antibodies for ADORA3
     See all of Abcam's Antibodies, Kits and Proteins for ADORA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADORA3
     Antibodies for ADORA3
     ELISAs for ADORA3
     CLIAs for ADORA3
     Search LifeMap BioReagents cell lines for ADORA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA3
     SwitchGear 3'UTR luciferase reporter plasmids for ADORA3
     SwitchGear Promoter luciferase reporter plasmids for ADORA3
     ThermoFisher Antibodies for ADORA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADORA3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADORA3
    Customized:
     lentivirus for stable overexpression of ADORA3
     lentivirus expression plasmids for stable overexpression of ADORA3
     adenovirus for overexpression of ADORA3
     LSBio Antibodies in human, mouse, rat for ADORA3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADORA3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4