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Aliases for ADORA2B Gene

Aliases for ADORA2B Gene

  • Adenosine A2b Receptor 2 3
  • ADORA2 3

External Ids for ADORA2B Gene

Previous GeneCards Identifiers for ADORA2B Gene

  • GC17P016209
  • GC17P016958
  • GC17P015791
  • GC17P016048
  • GC17P015788
  • GC17P015715
  • GC17P015949

Summaries for ADORA2B Gene

Entrez Gene Summary for ADORA2B Gene

  • This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA2B Gene

ADORA2B (Adenosine A2b Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled adenosine receptor activity. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA2B Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for ADORA2B Gene

  • Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels in the lung, blood vessels and eye.

Gene Wiki entry for ADORA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA2B Gene

Genomics for ADORA2B Gene

Regulatory Elements for ADORA2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADORA2B Gene

Chromosome:
17
Start:
15,927,783 bp from pter
End:
15,975,896 bp from pter
Size:
48,114 bases
Orientation:
Plus strand

Genomic View for ADORA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA2B Gene

Proteins for ADORA2B Gene

  • Protein details for ADORA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29275-AA2BR_HUMAN
    Recommended name:
    Adenosine receptor A2b
    Protein Accession:
    P29275

    Protein attributes for ADORA2B Gene

    Size:
    332 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADORA2B Gene

Proteomics data for ADORA2B Gene at MOPED

Post-translational modifications for ADORA2B Gene

  • Glycosylation at Asn 153 and Asn 163
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADORA2B Gene

Domains & Families for ADORA2B Gene

Gene Families for ADORA2B Gene

Suggested Antigen Peptide Sequences for ADORA2B Gene

Graphical View of Domain Structure for InterPro Entry

P29275

UniProtKB/Swiss-Prot:

AA2BR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA2B: view

Function for ADORA2B Gene

Molecular function for ADORA2B Gene

GENATLAS Biochemistry:
adenosine receptor B2,G protein coupled receptor superfamily,activating adenylate cyclase,expressed in keratinocytes and fibroblasts,upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with ADORA2B: view
genes like me logo Genes that share phenotypes with ADORA2B: view

Animal Models for ADORA2B Gene

MGI Knock Outs for ADORA2B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2B

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADORA2B Gene

Localization for ADORA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA2B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA2B Gene COMPARTMENTS Subcellular localization image for ADORA2B gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10101031
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7558011
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADORA2B: view

Pathways & Interactions for ADORA2B Gene

genes like me logo Genes that share pathways with ADORA2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10101031
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA --
GO:0006968 cellular defense response TAS 10101031
GO:0007186 G-protein coupled receptor signaling pathway TAS 7558011
genes like me logo Genes that share ontologies with ADORA2B: view

No data available for SIGNOR curated interactions for ADORA2B Gene

Drugs & Compounds for ADORA2B Gene

(90) Drugs for ADORA2B Gene - From: NovoSeek, IUPHAR, DGIdb, ApexBio, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, antagonist, Target 55
Adenosine Approved, Investigational Pharma Channel blocker, agonist, Target 340
Caffeine Approved Nutra Activator, antagonist 317
Regadenoson Approved Pharma Agonist 59
Enprofylline Approved Pharma Target, antagonist 0

(19) Additional Compounds for ADORA2B Gene - From: Tocris, IUPHAR, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IPDX
Antagonist
SCH4421416
Antagonist
XAC
Antagonist
BAY 60-6583
910487-58-0
CV 1808
53296-10-9
genes like me logo Genes that share compounds with ADORA2B: view

Transcripts for ADORA2B Gene

mRNA/cDNA for ADORA2B Gene

Unigene Clusters for ADORA2B Gene

Adenosine A2b receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2B

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA2B Gene

No ASD Table

Relevant External Links for ADORA2B Gene

GeneLoc Exon Structure for
ADORA2B
ECgene alternative splicing isoforms for
ADORA2B

Expression for ADORA2B Gene

mRNA expression in normal human tissues for ADORA2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA2B Gene

This gene is overexpressed in Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for ADORA2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADORA2B Gene



SOURCE GeneReport for Unigene cluster for ADORA2B Gene Hs.167046

genes like me logo Genes that share expression patterns with ADORA2B: view

Protein tissue co-expression partners for ADORA2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA2B Gene

Orthologs for ADORA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADORA2B 35
  • 83.48 (n)
  • 84.59 (a)
ADORA2B 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADORA2B 35
  • 91.84 (n)
  • 93.05 (a)
ADORA2B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora2b 35
  • 87.45 (n)
  • 87.65 (a)
Adora2b 16
Adora2b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADORA2B 35
  • 99.3 (n)
  • 99.4 (a)
ADORA2B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adora2b 35
  • 85.34 (n)
  • 86.14 (a)
oppossum
(Monodelphis domestica)
Mammalia ADORA2B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADORA2B 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADORA2B 35
  • 71.28 (n)
  • 68.49 (a)
ADORA2B 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adora2b 35
  • 67.81 (n)
  • 65.42 (a)
zebrafish
(Danio rerio)
Actinopterygii adora2b 35
  • 66.45 (n)
  • 66.24 (a)
adora2b 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 32 (a)
AdoR 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for ADORA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA2B Gene

ENSEMBL:
Gene Tree for ADORA2B (if available)
TreeFam:
Gene Tree for ADORA2B (if available)

Paralogs for ADORA2B Gene

Paralogs for ADORA2B Gene

(8) SIMAP similar genes for ADORA2B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ADORA2B Gene

genes like me logo Genes that share paralogs with ADORA2B: view

Variants for ADORA2B Gene

Sequence variations from dbSNP and Humsavar for ADORA2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs757623 -- 15,948,607(+) CTGCT(A/C/T)GTAGA intron-variant
rs758854 -- 15,942,137(+) GAAAT(C/T)TGTCC intron-variant
rs758855 -- 15,947,628(+) CAGAG(G/T)TAGTC intron-variant
rs758856 -- 15,947,882(+) TTTGG(G/T)TCCAG intron-variant
rs758857 -- 15,950,943(+) TCTGC(A/G)CCCAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADORA2B Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv907706 CNV Gain 21882294
dgv3062n71 CNV Gain 21882294
nsv512478 CNV Loss 21212237
esv2434647 CNV Deletion 19546169
esv2286288 CNV Deletion 18987734
esv2715705 CNV Deletion 23290073
esv1683190 CNV Deletion 17803354
esv2660526 CNV Deletion 23128226

Variation tolerance for ADORA2B Gene

Residual Variation Intolerance Score: 19.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADORA2B Gene

HapMap Linkage Disequilibrium report
ADORA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA2B Gene

Disorders for ADORA2B Gene

Relevant External Links for ADORA2B

Genetic Association Database (GAD)
ADORA2B
Human Genome Epidemiology (HuGE) Navigator
ADORA2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADORA2B
genes like me logo Genes that share disorders with ADORA2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADORA2B Gene

Publications for ADORA2B Gene

  1. Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. (PMID: 16581066) Phelps P.T. … Correll C.C. (Eur. J. Pharmacol. 2006) 23 25 26 67
  2. The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. (PMID: 15980878) Holgate S.T. (Br. J. Pharmacol. 2005) 23 25 26 67
  3. Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. (PMID: 7558011) Jacobson M.A. … Salvatore C.A. (Genomics 1995) 2 23 67
  4. Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling. (PMID: 19858092) Wen J. … Xia Y. (FASEB J. 2010) 23 67
  5. AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. (PMID: 19730798) Liu Y. … Downey J.M. (Basic Res. Cardiol. 2010) 23 67

Products for ADORA2B Gene

Sources for ADORA2B Gene

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