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ADORA2B Gene

protein-coding   GIFtS: 68
GCID: GC17P015788

Adenosine A2b Receptor

  See ADORA2B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine A2b Receptor1 2
ADORA22
Adenosine Receptor A2b2

External Ids:    HGNC: 2641   Entrez Gene: 1362   Ensembl: ENSG000001704257   OMIM: 6004465   UniProtKB: P292753   

Export aliases for ADORA2B gene to outside databases

Previous GC identifers: GC17P016209 GC17P016958 GC17P015791 GC17P016048 GC17P015715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADORA2B Gene:
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This
integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also
interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis
syndrome region on chromosome 17. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADORA2B Gene:
ADORA2B (adenosine A2b receptor) is a protein-coding gene. Diseases associated with ADORA2B include priapism. GO annotations related to this gene include G-protein coupled adenosine receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
cyclase

summary for ADORA2B Gene:
Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also
includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with
lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A2B receptors play a
role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage
function and stimulate mast cell mediator release. The human A2B receptor gene is localized on chromosome 17
(17p12-p11.2).

Gene Wiki entry for ADORA2B (Adenosine A2B receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADORA2B gene promoter:
         ATF-2   CBF-C   Gfi-1   CREB   CRE-BP1   CBF-B   CBF-A   deltaCREB   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADORA2B promoter sequence
   Search Chromatin IP Primers for ADORA2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADORA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p12

ADORA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA2B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P015788:  view genomic region     (about GC identifiers)

Start:
15,848,231 bp from pter      End:
15,879,210 bp from pter
Size:
30,980 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275 (See protein sequence)
Recommended Name: Adenosine receptor A2b  
Size: 332 amino acids; 36333 Da

Explore the universe of human proteins at neXtProt for ADORA2B: NX_P29275

Explore proteomics data for ADORA2B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn153, Asn163
  • Modification sites at PhosphoSitePlus

  • See ADORA2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000667.1  
    ENSEMBL proteins: 
     ENSP00000304501  
    Reactome Protein details: P29275

    ADORA2B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADORA: GPCR / Class A : Adenosine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: A2B receptor
    Adenosine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001634 Adenosn_rcpt
     IPR001435 Adeno_A2B_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P29275

    ProtoNet protein and cluster: P29275

    2 Blocks protein domains:
    IPB001435 Adenosine A2B receptor signature
    IPB001634 Adenosine receptor signature


    UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with ADORA2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AA2BR_HUMAN, P29275
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
    cyclase

         Genatlas biochemistry entry for ADORA2B:
    adenosine receptor B2,G protein coupled receptor superfamily,activating adenylate cyclase,expressed in
    keratinocytes and fibroblasts,upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
         
    Find genes that share ontologies with ADORA2B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADORA2B:
     Decreased substrate adherent c 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Adora2b):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  reproductive system 

    Find genes that share phenotypes with ADORA2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADORA2B: Adora2btm1Till Adora2btm1.1Msit Adora2btm1(KOMP)Vlcg

       genOway: Develop your customized and physiologically relevant rodent model for ADORA2B

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    miRTarBase miRNAs that target ADORA2B:
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    hsa-miR-374b hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidADORA2B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AA2BR_HUMAN, P29275: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7558011
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ADORA2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADORA2B About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    Adenosine P1 receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43
    5Development A2A receptor signaling
    Development A2B receptor action via G protein alpha s0.43


    Find genes that share SuperPaths with ADORA2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for ADORA2B
        Development A2B receptor- action via G-protein alpha s
    Regulation of CFTR activity (norm and CF)
    Signal transduction IP3 signaling

    3 BioSystems Pathways for ADORA2B
        GPCRs, Class A Rhodopsin-like
    C-MYB transcription factor network
    Nucleotide GPCRs


    2 Reactome Pathways for ADORA2B
        Adenosine P1 receptors
    G alpha (s) signalling events


    5 Kegg Pathways  (Kegg details for ADORA2B):
        Rap1 signaling pathway
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction
    Alcoholism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA2B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADORA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADORA2B (P292753 ENSP000003045014) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    ADAP008133, ENSP000003619654I2D: score=1 STRING: ENSP00000361965
    DCCP431463, ENSP000003891404I2D: score=1 STRING: ENSP00000389140
    SLC9A3R2Q155993, ENSP000004080054I2D: score=2 STRING: ENSP00000408005
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10101031
    GO:0002882positive regulation of chronic inflammatory response to non-antigenic stimulus IEA--
    GO:0006968cellular defense response TAS10101031
    GO:0007186G-protein coupled receptor signaling pathway TAS7558011
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--

    Find genes that share ontologies with ADORA2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ADORA2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSB 603Highly selective A2B antagonist[1092351-10-4]
    MRS 1706Potent and selective A2B inverse agonist[264622-53-9]
    MRS 1754Selective A2B antagonist[264622-58-4]
    BAY 60-6583Potent A2B receptor agonist; cardioprotective[910487-58-0]
    PSB 1115Selective human A2B receptor antagonist; water-soluble[409344-71-4]

    2 HMDB Compounds for ADORA2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--

    4 DrugBank Compounds for ADORA2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 16339914 20370661 20370662 17438146 17442976 20136829
    TheophyllineDimethylxanthine (see all 6)58-55-9targetantagonist16581066 3588607 16545350 11752352 15980878 12954362
    Enprofylline3-n-Propylxanthine (see all 4)41078-02-8targetantagonist11752352 15980878
    Defibrotide-- 83712-60-1target--8405101

    Selected IUPHAR Ligands for ADORA2B (A2B receptor) (see all 75)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]OSIP339391
    AntagonistAntagonist9.815194002
    [3H]PSB603
    AntagonistAntagonist9.419569717
    PSB603
    AntagonistAntagonist9.3919569717
    OSIP339391
    AntagonistAntagonist9.315194002
    [3H]MRS1754
    AntagonistAntagonist8.9611266650
    MRS1754
    AntagonistAntagonist8.811266650 10737749
    XAC
    AntagonistAntagonist7.8 - 8.811093773 11266650 15194002 10624567 10496952
    ATL802
    AntagonistAntagonist8.6310737749
    Bay60-6583
    AgonistAgonist8 - 8.5217353435
    MRE 2029F20
    AntagonistAntagonist8.26 - 8.516219300 14998332

    Selected Novoseek inferred chemical compound relationships for ADORA2B gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5'-n-ethylcarboxamidoadenosine 93.4 5 8982704 (1), 9105884 (1), 15472138 (1), 10362666 (1) (see all 5)
    cgs21680 82.4 1 9914161 (1)
    2 chloroadenosine 76.9 1 7889308 (1)
    isoalloxazine 71.7 1 17301835 (1)
    dpcpx 70.9 1 17077318 (1)
    cyclic amp 64 12 11518026 (1), 15795521 (1), 9453319 (1), 7950978 (1) (see all 9)
    xanthine 60.7 3 11906291 (2), 12014951 (1)
    theophylline 53.7 1 10725262 (1)
    adenylate 53.4 1 8022409 (1)
    nucleoside 34.9 2 19285919 (1), 18703227 (1)



    Find genes that share compounds with ADORA2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADORA2B gene: 
    NM_000676.2  

    Unigene Cluster for ADORA2B:

    Adenosine A2b receptor
    Hs.167046  [show with all ESTs]
    Unigene Representative Sequence: AK172851
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304222(uc002gpd.1) ENST00000582124
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ADORA2B

    Additional mRNA sequence: 

    AK172851.1 AY136748.1 BC025722.1 M97759.1 X68487.1 

    3 DOTS entries:

    DT.309524  DT.40131626  DT.100751372 

    Selected AceView cDNA sequences (see all 60):

    BC025722 CR621788 CA488648 X68487 BU740523 BM783394 CR616920 BM785007 
    BF507545 BX115652 AI336616 BM722841 CR620445 CA391570 NM_000676 AY136748 
    CD370629 CR592809 BE858844 CF147806 BI757182 BG025167 CA488092 BG193055 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADORA2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATTCAGT
    ADORA2B Expression
    About this image


    ADORA2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Smooth Muscle (Muscoskeletal System)
    ADORA2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADORA2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167046
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA2B: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADORA2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora2b1 , 5 adenosine A2b receptor1, 5 87.45(n)1
    87.65(a)1
      11 (37.96 cM)5
    115411  NM_007413.41  NP_031439.21 
     622489845 
    chicken
    (Gallus gallus)
    Aves ADORA2B1 adenosine A2b receptor 71.28(n)
    68.49(a)
      395971  NM_205087.1  NP_990418.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    37(a)
    35(a)
    many ↔ many
    many ↔ many
    4(126369517-126371479)
    GL343568.1(96739-97722)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adora2b1 adenosine A2b receptor 67.81(n)
    65.42(a)
      100496230  XM_002938923.2  XP_002938969.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adora2b1 adenosine A2b receptor 66.45(n)
    66.24(a)
      560100  NM_001039813.2  NP_001034902.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97533 G-protein coupled receptor protein
    signaling pathway more
    32(a)   99D8   --
    worm
    (Caenorhabditis elegans)
    Secernentea ador-16
    Protein ADOR-1, isoform b (ador-1) mRNA, complete ...
    21(a)
    1 → many
    II(12497210-12502878) WBGene00011878


    ENSEMBL Gene Tree for ADORA2B (if available)
    TreeFam Gene Tree for ADORA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADORA2B gene
    ADORA12  GPR1192  ADORA2A2  
    8 SIMAP similar genes for ADORA2B using alignment to 3 protein entries:     AA2BR_HUMAN (see all proteins):
    hA2aR    ADORA2A    ADORA1    ADORA3    DRD3    HRH2
    ADRB2    HTR7

    Find genes that share paralogs with ADORA2B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ADORA2B
    PGOHUM00000245194


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADORA2B (see all 741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157753801,2
    F--15846378(+) GGAACG/ATGATT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1162439281,2
    F--15846388(+) TGGTGG/AAGCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs2005927691,2
    --15846504(+) AATAG-/AAAAAA 1 -- us2k10--------
    rs27791931,2
    C,F,A,H--15846535(+) CACCCG/AGCTAG 1 -- us2k116Minor allele frequency- A:0.19NS EA NA CSA WA 850
    rs27791941,2
    C,F,A,H--15846558(+) GTGTGC/TTTTTG 1 -- us2k125Minor allele frequency- T:0.10NS EA NA WA CSA 2171
    rs1810157581,2
    C--15846580(+) TCCTCA/GTTGGT 1 -- us2k10--------
    rs1855989081,2
    --15846663(+) ACAGGA/GTCTCC 1 -- us2k10--------
    rs1905236611,2
    --15846683(+) CCAGCC/TTGGAT 1 -- us2k10--------
    rs797177101,2
    C,F--15846794(+) TGCCAC/TCGTGC 1 -- us2k12Minor allele frequency- T:0.08WA 120
    rs1471520001,2
    --15846796(+) CCACCA/GTGCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADORA2B (15848231 - 15879210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ADORA2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715705CNV Deletion23290073
    esv2715702CNV Deletion23290073
    esv2286288CNV Deletion18987734
    esv1683190CNV Deletion17803354
    esv2434647CNV Deletion19546169
    esv2660526CNV Deletion23128226
    nsv512478CNV Loss21212237
    dgv3062n71CNV Gain21882294
    nsv907706CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADORA2B
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600446    OMIM disorders: --

    1 disease for ADORA2B:    
    About MalaCards
    priapism


    Find genes that share disorders with ADORA2B           About GenesLikeMe

    10 Novoseek inferred disease relationships for ADORA2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 39.9 2 12714375 (1), 18630258 (1)
    asthma 38.4 4 16243321 (1), 15980878 (1), 9612090 (1), 18630258 (1)
    astrocytoma 29.9 4 7950978 (2), 8627294 (2)
    erythroleukemia 24 1 8022409 (1)
    cholera 14.9 1 8022409 (1)
    inflammation 6.19 3 19769545 (2), 19075778 (1)
    cancer 5.38 2 16211229 (1)
    necrosis 0 1 15569261 (1)
    breast cancer 0 1 15753948 (1)
    tumors 0 1 17404693 (1)

    Genetic Association Database (GAD): ADORA2B
    Human Genome Epidemiology (HuGE) Navigator: ADORA2B (8 documents)

    Export disorders for ADORA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ADORA2B gene, integrated from 10 sources (see all 195):
    (articles sorted by number of sources associating them with ADORA2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. (PubMed id 7558011)1, 2, 3, 9 Jacobson M.A.... Salvatore C.A. (Genomics 1995)
    2. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4, 9 Kim S.H....Park H.S. (Respir Med 2009)
    3. Molecular cloning and expression of an adenosine A2b receptor from human brain. (PubMed id 1325798)1, 2, 9 Pierce K.D.... Shine J. (Biochem. Biophys. Res. Commun. 1992)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia. (PubMed id 19841638)1, 9 Yang M....Qu X. (Immunol. Cell Biol. 2010)
    10. Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. (PubMed id 18703227)1, 9 Escudero C....Sobrevia L. (Placenta 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136 HGNC: 264 AceView: ADORA2B Ensembl:ENSG00000170425 euGenes: HUgn136
    ECgene: ADORA2B Kegg: 136 H-InvDB: ADORA2B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADORA2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADORA2B gene:
    Search GeneIP for patents involving ADORA2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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