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Aliases for ADORA2B Gene

Aliases for ADORA2B Gene

  • Adenosine A2b Receptor 2 3
  • Adenosine Receptor A2b 3
  • ADORA2 3

External Ids for ADORA2B Gene

Previous GeneCards Identifiers for ADORA2B Gene

  • GC17P016209
  • GC17P016958
  • GC17P015791
  • GC17P016048
  • GC17P015788
  • GC17P015715

Summaries for ADORA2B Gene

Entrez Gene Summary for ADORA2B Gene

  • This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA2B Gene

ADORA2B (Adenosine A2b Receptor) is a Protein Coding gene. Diseases associated with ADORA2B include priapism. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled adenosine receptor activity. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA2B Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for ADORA2B Gene

  • Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A2B receptors play a role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage function and stimulate mast cell mediator release. The human A2B receptor gene is localized on chromosome 17 (17p12-p11.2).

Gene Wiki entry for ADORA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA2B Gene

Genomics for ADORA2B Gene

Regulatory Elements for ADORA2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADORA2B Gene

15,944,917 bp from pter
15,975,896 bp from pter
30,980 bases
Plus strand

Genomic View for ADORA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA2B Gene

Proteins for ADORA2B Gene

  • Protein details for ADORA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A2b
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ADORA2B Gene

    332 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADORA2B Gene

Proteomics data for ADORA2B Gene at MOPED

Post-translational modifications for ADORA2B Gene

  • Glycosylation at Asn153 and Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADORA2B Gene

Domains for ADORA2B Gene

Gene Families for ADORA2B Gene

Suggested Antigen Peptide Sequences for ADORA2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA2B: view

Function for ADORA2B Gene

Molecular function for ADORA2B Gene

GENATLAS Biochemistry:
adenosine receptor B2,G protein coupled receptor superfamily,activating adenylate cyclase,expressed in keratinocytes and fibroblasts,upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with ADORA2B: view
genes like me logo Genes that share phenotypes with ADORA2B: view

Animal Models for ADORA2B Gene

MGI Knock Outs for ADORA2B:

Animal Model Products

miRNA for ADORA2B Gene

miRTarBase miRNAs that target ADORA2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2B

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADORA2B Gene

Localization for ADORA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA2B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADORA2B Gene COMPARTMENTS Subcellular localization image for ADORA2B gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7558011
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADORA2B: view

Pathways for ADORA2B Gene

genes like me logo Genes that share pathways with ADORA2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10101031
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA --
GO:0006968 cellular defense response TAS 10101031
GO:0007186 G-protein coupled receptor signaling pathway TAS 7558011
genes like me logo Genes that share ontologies with ADORA2B: view

Drugs for ADORA2B Gene

(4) Drugbank Compounds for ADORA2B Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
58-61-7 60961 Target agonist approved, investigational
83712-60-1 Target approved, investigational
  • 3-n-Propylxanthine
41078-02-8 1676 Target antagonist approved
  • 1,3-dimethyl-7H-purine-2,6-dione
58-55-9 2153 Target antagonist approved

(5) Tocris Compounds for ADORA2B Gene

Compound Action Cas Number
BAY 60-6583 Potent A2B receptor agonist; cardioprotective [910487-58-0]
MRS 1754 Selective A2B antagonist [264622-58-4]
PSB 0788 Selective A2B antagonist [1027513-54-7]
PSB 1115 Selective human A2B receptor antagonist; water-soluble [152529-79-8]
PSB 603 Highly selective A2B antagonist [1092351-10-4]

(6) ApexBio Compounds for ADORA2B Gene

Compound Action Cas Number
Adenine HCl Adenine receptor agonist [2922-28-3]
CGS 21680 HCl A2 adenosine receptor agonist [124431-80-7]
Istradefylline (KW-6002) Selective A2A receptor antagonist [155270-99-8]
Preladenant Adenosine A2A receptor antagonist [377727-87-2]
Ticlopidine HCl [53885-35-1]
Valsartan Angiotensin II AT1 receptor antagonist [137862-53-4]

(3) HMDB Compounds for ADORA2B Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
  • 3-N-Propylxanthine
  • 1,3-Dimethylxanthine

(75) IUPHAR Ligand for ADORA2B Gene

Ligand Type Action Affinity Pubmed IDs
SCH4421416 Antagonist Antagonist 10.3
[3H]OSIP339391 Antagonist Antagonist 9.8
CGS 15943 Antagonist Antagonist 9.4
[3H]PSB603 Antagonist Antagonist 9.4
OSIP339391 Antagonist Antagonist 9.3
SCH 58261 Antagonist Antagonist 9.2
[3H]DPCPX Antagonist Antagonist 9.2
ZM-241385 Antagonist Antagonist 9.1
preladenant Antagonist Antagonist 9.05
XAC Antagonist Antagonist 9
[3H]MRS1754 Antagonist Antagonist 8.96
BIIB014 Antagonist Antagonist 8.89
[3H]ZM 241385 Antagonist Antagonist 8.74
NECA Agonist Full agonist 8.7
AS101 Antagonist Antagonist 8.4
2-hexynyl-NECA Agonist Full agonist 8.3
MSX-2 Antagonist Antagonist 8.27
ST-1535 Antagonist Antagonist 8.18
CGS 21680 Agonist Full agonist 8.1
AS96 Antagonist Antagonist 8
istradefylline Antagonist Antagonist 7.92
DEPX Antagonist Antagonist 7.9
AS94 Antagonist Antagonist 7.8
AS95 Antagonist Antagonist 7.7
AS16 Antagonist Antagonist 7.7
AS74 Antagonist Antagonist 7.6
[125I]ABOPX Antagonist Antagonist 7.4
I-ABOPX Antagonist Antagonist 7.4
BW-A1433 Antagonist Antagonist 7.3
XCC Antagonist Antagonist 7.3
DPCPX Antagonist Antagonist 7.2
rolofylline Antagonist Antagonist 6.97
MRE 3008F20 Antagonist Antagonist 6.8
2-chloroadenosine Agonist Full agonist 6.8
LUF5981 Antagonist Antagonist 6.71
TCPA Agonist Agonist 6.68
AS70 Antagonist Antagonist 6.6
binodenoson Agonist Agonist 6.57
regadenoson Agonist Agonist 6.54
AS100 Antagonist Antagonist 6.5
MRS1220 Antagonist Antagonist 6.5
SLV320 Antagonist Antagonist 6.4
DAX Antagonist Antagonist 6.4
KF26777 Antagonist Antagonist 6.33
IB-MECA Agonist Full agonist 6.3
MRS1754 Antagonist Antagonist 6.3
IPDX Antagonist Antagonist 6.3
alloxazine Antagonist Antagonist 6.3
(R)-PIA Agonist Full agonist 6.2
CPX Antagonist Antagonist 6.2
ATL802 Antagonist Antagonist 6.18
cyclopentyladenosine Agonist Full agonist 6.1
AS99 Antagonist Antagonist 6.1
PSB36 Antagonist Antagonist 6.01
LAS38096 Antagonist Antagonist 6
MRE 2029F20 Antagonist Antagonist 6
HEMADO Agonist Agonist 5.92
N(6)-cyclohexyladenosine Agonist Full agonist 5.9
FK-453 Antagonist Antagonist 5.89
theophylline Antagonist Antagonist 5.8
MRS3558 Agonist Agonist 5.63
CCPA Agonist Full agonist 5.6
CVT-6883 Antagonist Antagonist 5.48
MRS1523 Antagonist Antagonist 5.44
Cl-IB-MECA Agonist Agonist 5.27
tonapofylline Antagonist Antagonist 5.19
(S)-PIA Agonist Full agonist 5.1
MRS1191 Antagonist Antagonist 5
PSB603 Antagonist Antagonist 5
GS9667 Agonist Agonist 5
Bay60-6583 Agonist Agonist 5
PSB1115 Antagonist Antagonist 5
AB-NECA Agonist Full agonist 4.7
adenosine Channel blocker None 3.2
caffeine Activator None

(19) Novoseek inferred chemical compound relationships for ADORA2B Gene

Compound -log(P) Hits PubMed IDs
5-n-ethylcarboxamidoadenosine 93.4 5
cgs21680 82.4 1
2 chloroadenosine 76.9 1
isoalloxazine 71.7 1
dpcpx 70.9 1
genes like me logo Genes that share compounds with ADORA2B: view

Transcripts for ADORA2B Gene

mRNA/cDNA for ADORA2B Gene

Unigene Clusters for ADORA2B Gene

Adenosine A2b receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2B

Clone Products

  • R&D Systems cDNA Clones for ADORA2B (Adenosine A2b R)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA2B Gene

No ASD Table

Relevant External Links for ADORA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADORA2B Gene

mRNA expression in normal human tissues for ADORA2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA2B Gene

This gene is overexpressed in Colon - Transverse (4.0).

Protein differential expression in normal tissues for ADORA2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADORA2B Gene

SOURCE GeneReport for Unigene cluster for ADORA2B Gene Hs.167046

genes like me logo Genes that share expressions with ADORA2B: view

Expression partners for ADORA2B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA2B Gene

Orthologs for ADORA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADORA2B 35
  • 83.48 (n)
  • 84.59 (a)
  • 84 (a)
(Canis familiaris)
Mammalia ADORA2B 35
  • 91.84 (n)
  • 93.05 (a)
  • 93 (a)
(Mus musculus)
Mammalia Adora2b 35
  • 87.45 (n)
  • 87.65 (a)
Adora2b 16
Adora2b 36
  • 88 (a)
(Pan troglodytes)
Mammalia ADORA2B 35
  • 99.3 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Adora2b 35
  • 85.34 (n)
  • 86.14 (a)
(Monodelphis domestica)
Mammalia ADORA2B 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ADORA2B 36
  • 60 (a)
(Gallus gallus)
Aves ADORA2B 35
  • 71.28 (n)
  • 68.49 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
-- 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adora2b 35
  • 67.81 (n)
  • 65.42 (a)
(Danio rerio)
Actinopterygii adora2b 35
  • 66.45 (n)
  • 66.24 (a)
adora2b 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 32 (a)
AdoR 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for ADORA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA2B Gene

Gene Tree for ADORA2B (if available)
Gene Tree for ADORA2B (if available)

Paralogs for ADORA2B Gene

Paralogs for ADORA2B Gene

(8) SIMAP similar genes for ADORA2B Gene using alignment to 3 proteins: Pseudogenes for ADORA2B Gene

genes like me logo Genes that share paralogs with ADORA2B: view

Variants for ADORA2B Gene

Sequence variations from dbSNP and Humsavar for ADORA2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs142648690 -- 15,967,299(+) TCTCA(C/G)TCAGT intron-variant
rs142497182 -- 15,957,412(+) GGCAA(A/G)CAGAT intron-variant
rs142477397 -- 15,974,209(+) CAGGC(-/TA)TAGTC intron-variant
rs142436632 -- 15,966,999(+) GGGAG(A/T)TGGAC intron-variant
rs142419120 -- 15,960,077(+) AGCCT(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADORA2B Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv907706 CNV Gain 21882294
dgv3062n71 CNV Gain 21882294
nsv512478 CNV Loss 21212237
esv2434647 CNV Deletion 19546169
esv2286288 CNV Deletion 18987734
esv2715705 CNV Deletion 23290073
esv1683190 CNV Deletion 17803354
esv2660526 CNV Deletion 23128226

Relevant External Links for ADORA2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA2B Gene

Disorders for ADORA2B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADORA2B Gene in MalaCards »

(1) Disease for ADORA2B Gene

(10) Novoseek inferred disease relationships for ADORA2B Gene

Disease -log(P) Hits PubMed IDs
cystic fibrosis 39.9 2
asthma 38.4 4
astrocytoma 29.9 4
erythroleukemia 24 1
cholera 14.9 1

Relevant External Links for ADORA2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADORA2B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ADORA2B Gene

Publications for ADORA2B Gene

  1. Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. (PMID: 7558011) Jacobson M.A. … Salvatore C.A. (Genomics 1995) 2 3 4 23
  2. Molecular cloning and expression of an adenosine A2b receptor from human brain. (PMID: 1325798) Pierce K.D. … Shine J. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  3. The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. (PMID: 15980878) Holgate S.T. (Br. J. Pharmacol. 2005) 23 25 26
  4. Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. (PMID: 16581066) Phelps P.T. … Correll C.C. (Eur. J. Pharmacol. 2006) 23 25 26
  5. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. (PMID: 7836474) Strohmeier G.R. … Madara J.L. (J. Biol. Chem. 1995) 3 23

Products for ADORA2B Gene

Sources for ADORA2B Gene

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