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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADORA2B Gene

protein-coding GIFtS: 67
GCID: GC17P015788

adenosine A2b receptor

Explore 24 diseases affiliated with
ADORA2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenosine A2b Receptor¹ ²
ADORA2²
Adenosine Receptor A2b²

External Ids:	HGNC: 264¹	Entrez Gene: 136²	Ensembl: ENSG00000170425⁷	OMIM: 600446⁵	UniProtKB: P29275³

Export aliases for ADORA2B gene to outside databases

Previous GC identifers: GC17P016209 GC17P016958 GC17P015791 GC17P016048 GC17P015715

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADORA2B:

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral

membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with

netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on

chromosome 17. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl

cyclase

summary for ADORA2B:

Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also

includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with

lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A2B receptors play a

role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage

function and stimulate mast cell mediator release. The human A2B receptor gene is localized on chromosome 17

(17p12-p11.2).

Gene Wiki entry for ADORA2B (Adenosine A2B receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADORA2B gene promoter:
ATF-2 CBF-C Gfi-1 CREB CRE-BP1 CBF-B CBF-A deltaCREB CP1A CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADORA2B promoter sequence

Search SABiosciences Chromatin IP Primers for ADORA2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12

ADORA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA2B gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P015788: view genomic region (about GC identifiers)

Start:	15,848,231 bp from pter	End:	15,879,210 bp from pter
Size:	30,980 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275 (See protein sequence)

Recommended Name: Adenosine receptor A2b

Size: 332 amino acids; 36333 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for ADORA2B: NX_P29275

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29275

ADORA2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000667.1

ENSEMBL proteins:

ENSP00000304501

Reactome Protein details: P29275
Human Recombinant Protein Products:

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7558011
GO:0009986	cell surface	--	--

ADORA2B for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADORA2B for domains About GeneDecksing

4 InterPro domains/families:

IPR001634 Adenosn_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR001435 Adeno_A2B_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P29275

ProtoNet protein and cluster: P29275

2 Blocks protein families:

IPB001435 Adenosine A2B receptor signature

IPB001634 Adenosine receptor signature

UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AA2BR_HUMAN, P29275

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl

cyclase

Genatlas biochemistry entry for ADORA2B:

adenosine receptor B2,G protein coupled receptor superfamily,activating adenylate cyclase,expressed in keratinocytes

and fibroblasts,upregulated in melanocytes exposed to 4-tertiary butyl-phenol (4-TBP)

miRNA Products:		miRTarBase miRNAs that target ADORA2B: hsa-mir-27b (MIRT004499)

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ADORA2B:
		hsa-miR-374b hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374a hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: ADORA2B 3' UTR sequence

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		Search LifeMap BioReagents cell lines for ADORA2B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA2B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001609	G-protein coupled adenosine receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	--	--

ADORA2B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ADORA2B:

Decreased substrate adherent c

Animal Models:
Mouse knock-outs for ADORA2B: Adora2b^tm1Till Adora2b^tm1.1Msit
6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Adora2b):

cardiovascular system	cellular	homeostasis/metabolism	immune system	mortality/aging
reproductive system

ADORA2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Nucleotide-like (purinergic) receptors

	Nucleotide-like (purinergic) receptors	1.00			Adenosine P1 receptors	0.25
	Nucleotide GPCRs	0.56

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

Development_A2B receptor- action via G-protein alpha s

Development A2B receptor: action via G-protein alpha s

1.00

Development_A2B receptor- action via G-protein alpha s

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ADORA2B

	Signal transduction IP3 signaling
	Development A2B receptor- action via G-protein alpha s

3 GeneGo (Thomson Reuters) Pathways for ADORA2B

	Development A2B receptor- action via G-protein alpha s
	Regulation of CFTR activity (norm and CF)
	Signal transduction IP3 signaling

3 BioSystems Pathways for ADORA2B

	GPCRs, Class A Rhodopsin-like
	Nucleotide GPCRs
	C-MYB transcription factor network

5/8 Reactome Pathways for ADORA2B (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Signal Transduction

1 PharmGKB Pathway for ADORA2B

Methotrexate Pathway (Cancer Cell), Pharmacodynamics

3 Kegg Pathways (Kegg details for ADORA2B):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction

ADORA2B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADORA2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for ADORA2B (P29275³ ENSP00000304501⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	P15311³, ENSP00000338934⁴	I2D: score=2 STRING: ENSP00000338934
NTN1	O95631³, ENSP00000173229⁴	I2D: score=1 STRING: ENSP00000173229
ADA	P00813³, ENSP00000361965⁴	I2D: score=1 STRING: ENSP00000361965
DCC	P43146³, ENSP00000389140⁴	I2D: score=1 STRING: ENSP00000389140
SLC9A3R2	Q15599³, ENSP00000408005⁴	I2D: score=2 STRING: ENSP00000408005

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	10101031
GO:0001973	adenosine receptor signaling pathway	--	--
GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus	IEA	--
GO:0006968	cellular defense response	TAS	10101031
GO:0007186	G-protein coupled receptor signaling pathway	TAS	7558011

ADORA2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADORA2B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADORA2B available from Tocris Bioscience About this table

Compound	Action	CAS #
PSB 0788	Selective A2B antagonist	--
MRS 1706	Potent and selective A2B inverse agonist	[264622-53-9]
MRS 1754	Selective A2B antagonist	[264622-58-4]
PSB 1115	Selective human A2B receptor antagonist; water-soluble	[409344-71-4]
BAY 60-6583	Potent A2B receptor agonist; cardioprotective	[910487-58-0]

2 HMDB Compounds for ADORA2B About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine	1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)	58-61-7	--
Theophylline	1,3-Dimethylxanthine (see all 96)	58-55-9	--

4 DrugBank Compounds for ADORA2B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine	2'-Deoxyadenosine (see all 11)	58-61-7	target	agonist	17321471 16339914 20370661 20370662 17438146 17442976 20136829
Theophylline	Dimethylxanthine (see all 6)	58-55-9	target	antagonist	16581066 3588607 16545350 11752352 15980878 12954362
Enprofylline	3-n-Propylxanthine (see all 4)	41078-02-8	target	antagonist	11752352 15980878
Defibrotide	--	83712-60-1	target	--	8405101

10/19 Novoseek chemical compound relationships for ADORA2B gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5'-n-ethylcarboxamidoadenosine	93.4	5	8982704 (1), 9105884 (1), 15472138 (1), 10362666 (1) (see all 5)
cgs21680	82.4	1	9914161 (1)
2 chloroadenosine	76.9	1	7889308 (1)
isoalloxazine	71.7	1	17301835 (1)
dpcpx	70.9	1	17077318 (1)
cyclic amp	64	12	11518026 (1), 15795521 (1), 9453319 (1), 7950978 (1) (see all 9)
xanthine	60.7	3	11906291 (2), 12014951 (1)
theophylline	53.7	1	10725262 (1)
adenylate	53.4	1	8022409 (1)
nucleoside	34.9	2	19285919 (1), 18703227 (1)

Search CenterWatch for drugs/clinical trials and news about ADORA2B / AA2BR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADORA2B gene:

NM_000676.2

Unigene Cluster for ADORA2B:

Adenosine A2b receptor

Hs.167046 [show with all ESTs]

Unigene Representative Sequence: AK172851

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000304222(uc002gpd.1) ENST00000582124

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Additional cDNA sequence:

AK172851.1 AY136748.1 BC025722.1 M97759.1 X68487.1

3 DOTS entries:

DT.309524 DT.40131626 DT.100751372

24/60 AceView cDNA sequences (see all 60):

BM722841 CA391570 CR621788 AI336616 CR616920 CR620445 BM783394 BM785007

BU740523 AY136748 BF507545 BE858844 BC025722 X68487 CA488648 CD370629

BX115652 CR592809 NM_000676 BG025167 BX341078 BI753600 BI757182 CF147806

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADORA2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATTCAGT

About this image

ADORA2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Selective marker (cell-identifying gene)

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See ADORA2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADORA2B

SOURCE GeneReport for Unigene cluster: Hs.167046

SABiosciences Expression via Pathway-Focused PCR Arrays including ADORA2B:

G Protein Coupled Receptors 384HT in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADORA2B gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADORA2B¹	adenosine A2b receptor	71.28(n) 68.49(a)		395971 NM_205087.1 NP_990418.1
zebrafish (Danio rerio)	Actinopterygii	adora2b¹	adenosine A2b receptor	65.18(n) 65.92(a)		560100 NM_001039813.2 NP_001034902.1
fruit fly (Drosophila melanogaster)	Insecta	CG9753³	G-protein coupled receptor protein signaling pathway more	32(a)		99D8 --
worm (Caenorhabditis elegans)	Secernentea	T21B4.4⁶	Protein T21B4.4, isoform b	20(a)	1 → many	II(12497146-12502814)

ENSEMBL Gene Tree for ADORA2B (if available)
TreeFam Gene Tree for ADORA2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADORA2B gene

ADORA1² GPR119² ADORA3² ADORA2A²

8 SIMAP similar genes for ADORA2B using alignment to 3 protein entries: AA2BR_HUMAN (see all proteins):

hA2aR ADORA2A ADORA1 ADORA3 DRD3 HRH2

ADRB2 HTR7

ADORA2B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADORA2B
PGOHUM00000245194

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115775380^1,2	F,	--	15846378(+)	`GGAACG/ATGATT`	1	--	us2k¹		1		WA	118
rs116243928^1,2	F,	--	15846388(+)	`TGGTGG/AAGCAG`	1	--	us2k¹		1		WA	118
rs200592769^1,2		--	15846504(+)	`AATAG-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs2779193^1,2	C,F,A,H,	--	15846535(+)	`CACCCG/AGCTAG`	1	--	us2k¹		16		NS EA NA CSA WA	850
rs2779194^1,2	C,F,A,H,	--	15846558(+)	`GTGTGC/TTTTTG`	1	--	us2k¹		25		NS EA NA WA CSA	2171
rs181015758^1,2		--	15846580(+)	`TCCTCA/GTTGGT`	1	--	us2k¹		0	--	--	--	--
rs185598908^1,2		--	15846663(+)	`ACAGGA/GTCTCC`	1	--	us2k¹		0	--	--	--	--
rs190523661^1,2		--	15846683(+)	`CCAGCC/TTGGAT`	1	--	us2k¹		0	--	--	--	--
rs79717710^1,2	C,	--	15846794(+)	`TGCCAC/TCGTGC`	1	--	us2k¹		2		WA	120
rs147152000^1,2		--	15846796(+)	`CCACCA/GTGCCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADORA2B (15848231 - 15879210 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ADORA2B
1 CNV: 102415
2 Indels: 45509 25783

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADORA2B for disorders           About GeneDecksing

OMIM gene information: 600446    OMIM disorders: --

20/24 diseases for ADORA2B (see all 24):    About MalaCards

smith-magenis syndrome pre-eclampsia interleukin receptor chronic obstructive pulmonary disease

cystic fibrosis priapism pulmonary disease eclampsia

cholera bladder carcinoma fibrosis astrocytoma

hepatitis b breast cancer asthma colon carcinoma

ischemia atherosclerosis hepatitis carcinoma

10 Novoseek disease relationships for ADORA2B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	39.9	2	12714375 (1), 18630258 (1)
asthma	38.4	4	16243321 (1), 15980878 (1), 9612090 (1), 18630258 (1)
astrocytoma	29.9	4	7950978 (2), 8627294 (2)
erythroleukemia	24	1	8022409 (1)
cholera	14.9	1	8022409 (1)
inflammation	6.19	3	19769545 (2), 19075778 (1)
cancer	5.38	2	16211229 (1)
necrosis	0	1	15569261 (1)
breast cancer	0	1	15753948 (1)
tumors	0	1	17404693 (1)

Human Genome Epidemiology (HuGE) Navigator: ADORA2B (8 documents)

Export disorders for ADORA2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADORA2B gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with ADORA2B)

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Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. (PubMed id 7558011)^{1, 2, 3, 9} Jacobson M.A.... Salvatore C.A. (1995)
Molecular cloning and expression of an adenosine A2b receptor from human brain. (PubMed id 1325798)^{1, 2, 9} Pierce K.D.... Shine J. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
HIF-dependent induction of adenosine receptor A2b ske ws human dendritic cells to a Th2-stimulating phenotype under hypoxia. (PubMed id 19841638)^{1, 9} Yang M....Qu X. (2010)
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. (PubMed id 18703227)^{1, 9} Escudero C....Sobrevia L. (2008)
Adenosine stimulates fibroblast growth factor-7 gene expression via adenosine A2b receptor signaling in dermal papilla cells. (PubMed id 17301835)^{1, 9} Iino M....Arase S. (2007)
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. (PubMed id 11906291)^{1, 9} Hayallah A.M....Muller C.E. (2002)
The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. (PubMed id 7836474)^{1, 9} Strohmeier G.R....Madara J.L. (1995)
HIF-dependent induction of adenosine A2B receptor in hypoxia. (PubMed id 17077301)^{1, 9} Kong T.... Colgan S.P. (2006)
Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. (PubMed id 16581066)^{7, 9} Phelps P.T....Correll C.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 136	HGNC: 264	AceView: ADORA2B	Ensembl:ENSG00000170425	euGenes: HUgn136
ECgene: ADORA2B	Kegg: 136	H-InvDB: ADORA2B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADORA2B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADORA2B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADORA2B gene:
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