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Aliases for ADORA2A Gene

Aliases for ADORA2A Gene

  • Adenosine A2a Receptor 2 3
  • ADORA2 3 4
  • Adenosine Receptor Subtype A2a 3
  • Adenosine Receptor A2a 3
  • A2aR 3
  • RDC8 3

External Ids for ADORA2A Gene

Previous HGNC Symbols for ADORA2A Gene

  • ADORA2

Previous GeneCards Identifiers for ADORA2A Gene

  • GC22P021519
  • GC22P023148
  • GC22P023153
  • GC22P022997
  • GC22P024813
  • GC22P007773

Summaries for ADORA2A Gene

Entrez Gene Summary for ADORA2A Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

GeneCards Summary for ADORA2A Gene

ADORA2A (Adenosine A2a Receptor) is a Protein Coding gene. Diseases associated with ADORA2A include acute encephalopathy with biphasic seizures and late reduced diffusion and ischemia. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA2A Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for ADORA2A Gene

  • Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes, blood platelets, striatopallidal GABAergic neurons and the olfactory bulb. Lower expression levels are also found in the heart, lungs and blood vessels. A2A receptors mediate a sustained cardioprotective function during cardiac ischemia, inhibit neutrophil degranulation in neutrophil-mediated tissue injury and have been implicated in both neuroprotective and neurodegenerative effects. The human A2A receptor gene is localized on chromosome 22 (22q11.23).

Gene Wiki entry for ADORA2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA2A Gene

Genomics for ADORA2A Gene

Regulatory Elements for ADORA2A Gene

Genomic Location for ADORA2A Gene

24,417,879 bp from pter
24,442,360 bp from pter
24,482 bases
Plus strand

Genomic View for ADORA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA2A Gene

Proteins for ADORA2A Gene

  • Protein details for ADORA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A2a
    Protein Accession:
    Secondary Accessions:
    • B2R7E0

    Protein attributes for ADORA2A Gene

    412 amino acids
    Molecular mass:
    44707 Da
    Quaternary structure:
    • Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.
    • Sequence=AAA58356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADORA2A Gene

neXtProt entry for ADORA2A Gene

Proteomics data for ADORA2A Gene at MOPED

Post-translational modifications for ADORA2A Gene

  • Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
  • Glycosylation at Asn154
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADORA2A Gene

Domains for ADORA2A Gene

Gene Families for ADORA2A Gene

Suggested Antigen Peptide Sequences for ADORA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface
  • Belongs to the G-protein coupled receptor 1 family.
  • The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA2A: view

Function for ADORA2A Gene

Molecular function for ADORA2A Gene

GENATLAS Biochemistry:
adenosine receptor A2A,mainly expressed in the basal ganglia and immune tissues,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IDA 21393508
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 11571652
GO:0019899 enzyme binding IPI 16339847
GO:0031802 type 5 metabotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with ADORA2A: view
genes like me logo Genes that share phenotypes with ADORA2A: view

Animal Models for ADORA2A Gene

MGI Knock Outs for ADORA2A:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ADORA2A Gene

Localization for ADORA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADORA2A Gene COMPARTMENTS Subcellular localization image for ADORA2A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 21393508
GO:0012505 endomembrane system IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with ADORA2A: view

Pathways for ADORA2A Gene

genes like me logo Genes that share pathways with ADORA2A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0001975 response to amphetamine IEA --
GO:0006171 cAMP biosynthetic process TAS 10899090
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ADORA2A: view

Drugs for ADORA2A Gene

(15) Drugbank Compounds for ADORA2A Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
58-61-7 60961 Target agonist approved, investigational
83712-60-1 Target approved, investigational
  • Oxpentifylline
6493-05-6 4740 Target antagonist approved, investigational
  • 1-methyltheobromine
58-08-2 2519 Target antagonist, multitarget approved
  • (+-)-7-(2,3-Dihydroxypropyl)theophylline
479-18-5 3182 Target antagonist approved

(5) Tocris Compounds for ADORA2A Gene

Compound Action Cas Number
CGS 21680 hydrochloride A2A agonist [124431-80-7]
Istradefylline Potent and selective adenosine A2A receptor antagonist [155270-99-8]
SCH 442416 Very selective, high affinity A2A antagonist [316173-57-6]
SCH 58261 Potent, highly selective A2A antagonist [160098-96-4]
ZM 241385 Potent, highly selective A2A antagonist [139180-30-6]

(7) ApexBio Compounds for ADORA2A Gene

Compound Action Cas Number
Adenine HCl Adenine receptor agonist [2922-28-3]
CGS 21680 HCl A2 adenosine receptor agonist [124431-80-7]
Istradefylline (KW-6002) Selective A2A receptor antagonist [155270-99-8]
Preladenant Adenosine A2A receptor antagonist [377727-87-2]
Ticlopidine HCl [53885-35-1]
Tozadenant Adenosine 2a receptor antagonist,novel and selective [870070-55-6]
Valsartan Angiotensin II AT1 receptor antagonist [137862-53-4]

(8) HMDB Compounds for ADORA2A Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
  • 1,3,7-Trimethyl-2,6-dioxopurine
  • Dihydroxypropyl Theophylline
  • Mefloquinone
  • Choline theophylline

(86) IUPHAR Ligand for ADORA2A Gene

Ligand Type Action Affinity Pubmed IDs
SCH4421416 Antagonist Antagonist 10.3
CGS 15943 Antagonist Antagonist 9.4
apadenoson Agonist Agonist 9.3
SCH 58261 Antagonist Antagonist 9.2
MRS1093 Antagonist Antagonist 9.2
ZM-241385 Antagonist Antagonist 9.1
preladenant Antagonist Antagonist 9.05
[3H]SCH 58261 Antagonist Antagonist 9
XAC Antagonist Antagonist 9
BIIB014 Antagonist Antagonist 8.89
[3H]ZM 241385 Antagonist Antagonist 8.74
NECA Agonist Full agonist 8.7
(R,S)-PHPNECA Agonist Full agonist 8.5
2-hexynyl-NECA Agonist Full agonist 8.3
MSX-2 Antagonist Antagonist 8.27
ST-1535 Antagonist Antagonist 8.18
CGS 21680 Agonist Full agonist 8.1
[3H]XAC Antagonist Antagonist 8
istradefylline Antagonist Antagonist 7.92
KF 17837S Antagonist Antagonist 7.7
[3H]CGS 21680 Agonist Full agonist 7.7
[3H]NECA Agonist Full agonist 7.7
DPCPX Antagonist Antagonist 7.2
CV-1808 Agonist Full agonist 7.1
rolofylline Antagonist Antagonist 6.97
MRE 3008F20 Antagonist Antagonist 6.8
2-chloroadenosine Agonist Full agonist 6.8
LUF5981 Antagonist Antagonist 6.71
TCPA Agonist Agonist 6.68
binodenoson Agonist Agonist 6.57
regadenoson Agonist Agonist 6.54
SLV320 Antagonist Antagonist 6.4
CGS 24012 Agonist Full agonist 6.4
KF26777 Antagonist Antagonist 6.33
IB-MECA Agonist Full agonist 6.3
MRS1754 Antagonist Antagonist 6.3
(R)-PIA Agonist Full agonist 6.2
PENECA Agonist Full agonist 6.2
CPX Antagonist Antagonist 6.2
ATL802 Antagonist Antagonist 6.18
cyclopentyladenosine Agonist Full agonist 6.1
CPFPX Antagonist Antagonist 6.03
PSB36 Antagonist Antagonist 6.01
galangin Antagonist Antagonist 6
LAS38096 Antagonist Antagonist 6
MRE 2029F20 Antagonist Antagonist 6
HEMADO Agonist Agonist 5.92
N(6)-cyclohexyladenosine Agonist Full agonist 5.9
FK-453 Antagonist Antagonist 5.89
PSB-11 Antagonist Antagonist 5.89
GR79236 Agonist Agonist 5.89
theophylline Antagonist Antagonist 5.8
CV-1674 Agonist Full agonist 5.8
tecadenoson Agonist Agonist 5.64
MRS3558 Agonist Agonist 5.63
CCPA Agonist Full agonist 5.6
PSB-10 Antagonist Antagonist 5.57
MRS1042 Antagonist Antagonist 5.5
flavone Antagonist Antagonist 5.5
MRS1041 Antagonist Antagonist 5.5
metrifudil Agonist Full agonist 5.5
CVT-6883 Antagonist Antagonist 5.48
MRS1523 Antagonist Antagonist 5.44
AB-MECA Agonist Full agonist 5.4
APNEA Agonist Full agonist 5.3
Cl-IB-MECA Agonist Agonist 5.27
MRS928 Antagonist Antagonist 5.2
tonapofylline Antagonist Antagonist 5.19
(S)-PIA Agonist Full agonist 5.1
MRS5151 Agonist Agonist 5
MRS1191 Antagonist Antagonist 5
PSB603 Antagonist Antagonist 5
GS9667 Agonist Agonist 5
Bay60-6583 Agonist Agonist 5
MRS1065 Antagonist Antagonist 4.9
morin Antagonist Antagonist 4.8
MRS1086 Antagonist Antagonist 4.6
MRS1132 Antagonist Antagonist 4.6
MRS1066 Antagonist Antagonist 4.5
visnagin Antagonist Antagonist 4.4
sakuranetin Antagonist Antagonist 4.4
MRS1084 Antagonist Antagonist 4.3
MRS1088 Antagonist Antagonist 4.3
MRS923 Antagonist Antagonist 4.3
adenosine Channel blocker None 3.2
caffeine Activator None

(94) Novoseek inferred chemical compound relationships for ADORA2A Gene

Compound -log(P) Hits PubMed IDs
5-n-ethylcarboxamidoadenosine 91.9 16
cgs21680 89.4 4
regadenoson 86.3 10
binodenoson 86 6
istradefylline 85.4 5

(2) PharmGKB related drug/compound annotations for ADORA2A Gene

Drug/compound Annotation
caffeine Clinical Annotation
methotrexate Clinical Annotation
genes like me logo Genes that share compounds with ADORA2A: view

Compound Products

Transcripts for ADORA2A Gene

Unigene Clusters for ADORA2A Gene

Adenosine A2a receptor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA2A Gene

No ASD Table

Relevant External Links for ADORA2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADORA2A Gene

mRNA expression in normal human tissues for ADORA2A Gene

mRNA differential expression in normal tissues according to GTEx for ADORA2A Gene

This gene is overexpressed in Liver (6.2), Whole Blood (4.7), Brain - Putamen (basal ganglia) (4.7), and Brain - Nucleus accumbens (basal ganglia) (4.5).

SOURCE GeneReport for Unigene cluster for ADORA2A Gene Hs.197029

genes like me logo Genes that share expressions with ADORA2A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ADORA2A Gene

Orthologs for ADORA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADORA2A 35
  • 84.44 (n)
  • 83.67 (a)
  • 82 (a)
(Canis familiaris)
Mammalia ADORA2A 35
  • 91.02 (n)
  • 93.2 (a)
  • 93 (a)
(Mus musculus)
Mammalia Adora2a 35
  • 84.46 (n)
  • 84.79 (a)
Adora2a 16
Adora2a 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADORA2A 35
  • 99.51 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Adora2a 35
  • 83.62 (n)
  • 84.29 (a)
(Monodelphis domestica)
Mammalia ADORA2A 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 71 (a)
(Gallus gallus)
Aves ADORA2A 35
  • 71.94 (n)
  • 73.99 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia ADORA2A 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adora2a 35
  • 66.76 (n)
  • 69.44 (a)
(Danio rerio)
Actinopterygii adora2ab 35
  • 67.81 (n)
  • 70.19 (a)
adora2aa 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 36 (a)
AdoR 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11260 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for ADORA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA2A Gene

Gene Tree for ADORA2A (if available)
Gene Tree for ADORA2A (if available)

Paralogs for ADORA2A Gene

Paralogs for ADORA2A Gene

genes like me logo Genes that share paralogs with ADORA2A: view

Variants for ADORA2A Gene

Sequence variations from dbSNP and Humsavar for ADORA2A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_011836 -
VAR_011835 -
VAR_003451 -

Structural Variations from Database of Genomic Variants (DGV) for ADORA2A Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv914629 CNV Gain 21882294
esv2724068 CNV Deletion 23290073
nsv834160 CNV Gain 17160897
nsv914633 CNV Loss 21882294
nsv9884 CNV Gain+Loss 18304495
nsv914634 CNV Loss 21882294

Relevant External Links for ADORA2A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA2A Gene

Disorders for ADORA2A Gene

(2) University of Copenhagen DISEASES for ADORA2A Gene

(31) Novoseek inferred disease relationships for ADORA2A Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 64.9 41
basal ganglia disorders 55.2 1
huntington disease 52.4 7
neurodegenerative diseases 43.2 3
catalepsy 43.2 2

Relevant External Links for ADORA2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADORA2A: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADORA2A Gene

Publications for ADORA2A Gene

  1. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. (PMID: 17616786) Cornelis M.C. … Campos H. (Am. J. Clin. Nutr. 2007) 3 23 25 26 48
  2. The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. (PMID: 17558310) Riksen N.P. … Rongen G.A. (Pharmacogenet. Genomics 2007) 3 23 25 26
  3. Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PMID: 11515749) Yamada K. … Yoshikawa T. (J Neural Transm 2001) 3 23 48
  4. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PMID: 15257174) Wright K. … Griffiths L.R. (J. Hypertens. 2004) 3 23 48
  5. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. (PMID: 17329997) RActey J.V. … Landolt H.P. (Clin. Pharmacol. Ther. 2007) 3 23 48

Products for ADORA2A Gene

Sources for ADORA2A Gene

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