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ADORA2A Gene

protein-coding   GIFtS: 72
GCID: GC22P024813

Adenosine A2a Receptor


(Previous symbol: ADORA2)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adenosine A2a Receptor1 2
ADORA21 2 3
A2aR2
RDC82
Adenosine Receptor A2a2
Adenosine Receptor Subtype A2a2

External Ids:    HGNC: 2631   Entrez Gene: 1352   Ensembl: ENSG000001282717   OMIM: 1027765   UniProtKB: P292743   
ORGUL members:         

Export aliases for ADORA2A gene to outside databases

Previous GC identifers: GC22P021519 GC22P023148 GC22P023153 GC22P022997 GC22P007773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADORA2A Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR)
superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins
that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an
adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially
interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an
important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood
flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such
as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript
variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and
coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is
thought to be non-coding. (provided by RefSeq, Jun 2013)

GeneCards Summary for ADORA2A Gene:
ADORA2A (adenosine A2a receptor) is a protein-coding gene. Diseases associated with ADORA2A include acute encephalopathy with biphasic seizures and late reduced diffusion, and carrion's disease. GO annotations related to this gene include enzyme binding and identical protein binding. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
cyclase

summary for ADORA2A Gene:
Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also
includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes,
blood platelets, striatopallidal GABAergic neurons and the olfactory bulb. Lower expression levels are also
found in the heart, lungs and blood vessels. A2A receptors mediate a sustained cardioprotective function
during cardiac ischemia, inhibit neutrophil degranulation in neutrophil-mediated tissue injury and have been
implicated in both neuroprotective and neurodegenerative effects. The human A2A receptor gene is localized
on chromosome 22 (22q11.23).

Gene Wiki entry for ADORA2A (Adenosine A2A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADORA2A gene promoter:
         SRF   STAT1   Pax-5   SRF (504 AA)   NF-kappaB   GATA-2   PPAR-alpha   NF-kappaB2   Zic1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ADORA2A promoter sequence
   Search Chromatin IP Primers for ADORA2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADORA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

ADORA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA2A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024813:  view genomic region     (about GC identifiers)

Start:
24,813,847 bp from pter      End:
24,838,328 bp from pter
Size:
24,482 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274 (See protein sequence)
Recommended Name: Adenosine receptor A2a  
Size: 412 amino acids; 44707 Da
Subunit: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with
DRD4
Sequence caution: Sequence=AAA58356.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for ADORA2A (see all 14):
1MMH (3D)        1UPE (3D)        2YDO (3D)        2YDV (3D)        3EML (3D)        3PWH (3D)    
Secondary accessions: B2R7E0

Explore the universe of human proteins at neXtProt for ADORA2A: NX_P29274

Explore proteomics data for ADORA2A at MOPED

Post-translational modifications: 

  • Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface1
  • Glycosylation2 at Asn154
  • Modification sites at PhosphoSitePlus

  • See ADORA2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000666.2  NP_001265426.1  NP_001265427.1  NP_001265428.1  NP_001265429.1  

    ENSEMBL proteins: 
     ENSP00000404497   ENSP00000473799   ENSP00000474895   ENSP00000414802   ENSP00000474097  
     ENSP00000336630   ENSP00000475000   ENSP00000397071   ENSP00000400190  
    Reactome Protein details: P29274

    ADORA2A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ADORA2A Protein
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    OriGene Protein Over-expression Lysate for ADORA2A
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    Novus Biologicals ADORA2A Proteins
    Novus Biologicals ADORA2A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ADORA2A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADORA2A
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADORA2A
    OriGene Custom Antibody Services for ADORA2A
    Novus Biologicals ADORA2A Antibodies
    Abcam antibodies for ADORA2A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ADORA2A
    LSBio Antibodies in human, mouse, rat for ADORA2A

    ADORA2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript ADORA2A-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADORA: GPCR / Class A : Adenosine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: A2A receptor
    Adenosine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001634 Adenosn_rcpt
     IPR001513 Adeno_A2A_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P29274

    ProtoNet protein and cluster: P29274

    2 Blocks protein domains:
    IPB001513 Adenosine A2A receptor signature
    IPB001634 Adenosine receptor signature


    UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274
    Domain: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to
    the cell surface
    Similarity: Belongs to the G-protein coupled receptor 1 family


    ADORA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AA2AR_HUMAN, P29274
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
    cyclase

         Genatlas biochemistry entry for ADORA2A:
    adenosine receptor A2A,mainly expressed in the basal ganglia and immune tissues,G protein coupled receptor
    superfamily,activating adenylate cyclase

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IDA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI11571652
    GO:0019899enzyme binding IPI16339847
    GO:0031802type 5 metabotropic glutamate receptor binding IEA--
         
    ADORA2A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADORA2A:
     Decreased substrate adherent c  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adora2a):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  muscle  nervous system  respiratory system 
     vision/eye 

    ADORA2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADORA2A: Adora2atm1Jfc Adora2atm1Map Adora2atm1.1Dyj

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADORA2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADORA2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADORA2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADORA2A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ADORA2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADORA2A (see all 23):
    hsa-miR-34b* hsa-miR-3938 hsa-miR-15a hsa-miR-503 hsa-miR-339-5p hsa-miR-766 hsa-miR-424 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidADORA2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADORA2A
    Predesigned siRNA for gene silencing in human, mouse, rat ADORA2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADORA2A

    Clone
    Products:
         
    OriGene clones in human, mouse for ADORA2A (see all 7)
    OriGene ORF clones in mouse, rat for ADORA2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADORA2A (NM_000675)
    Sino Biological Human cDNA Clone for ADORA2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADORA2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA2A

    Cell Line
    Products:
         
    GenScript ADORA2A-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADORA2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AA2AR_HUMAN, P29274: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP--
    GO:0012505endomembrane system IEA--
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane TAS10051547

    ADORA2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADORA2A About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    Adenosine P1 receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Activation of TRKA receptors
    Activation of TRKA receptors
    NGF-independant TRKA activation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ADORA2A
        Development A2A receptor signaling
    Signal transduction IP3 signaling

    5 BioSystems Pathways for ADORA2A
        GPCRs, Other
    Monoamine Transport
    GPCRs, Class A Rhodopsin-like
    HIF-2-alpha transcription factor network
    Nucleotide GPCRs


    3 Reactome Pathways for ADORA2A
        Adenosine P1 receptors
    G alpha (s) signalling events
    NGF-independant TRKA activation


    Selected Kegg Pathways  (Kegg details for ADORA2A) (see all 6):
        Rap1 signaling pathway
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction
    Parkinson's disease


    ADORA2A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA2A: 
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADORA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADORA2A (P292741, 2, 3 ENSP000003366304) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292741, 2EBI-2902702,EBI-2902702 MINT-6699346 MINT-6700472 MINT-6797129 MINT-6797142 MINT-6797156 MINT-6699330
    CALM2P621581, 3EBI-2902702,EBI-397435 I2D: score=3 
    CALM3P621581, 3EBI-2902702,EBI-397435 I2D: score=3 
    ADORA1P305421, 3, ENSP000003085494EBI-2902702,EBI-2903663 I2D: score=4 STRING: ENSP00000308549
    CYTH2Q994181, 3, ENSP000004082364EBI-2902702,EBI-448974 I2D: score=3 STRING: ENSP00000408236
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 58):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001973adenosine receptor signaling pathway ----
    GO:0001975response to amphetamine IEA--
    GO:0006171cAMP biosynthetic process TAS10899090
    GO:0006355regulation of transcription, DNA-templated IEA--

    ADORA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADORA2A
      Browse compounds at ApexBio 

    Compounds for ADORA2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SCH 442416 Very selective, high affinity A2A antagonist [316173-57-6]
    ANR 94Adenosine A2A antagonist[634924-89-3]
    CGS 21680 hydrochlorideA2A agonist[124182-57-6]
    SCH 58261 Potent, highly selective A2A antagonist [160098-96-4]
    ZM 241385 Potent, highly selective A2A antagonist [139180-30-6]

    3 HMDB Compounds for ADORA2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    CaffeineHycomine (see all 15)58-08-2--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--

    Selected DrugBank Compounds for ADORA2A (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 16339914 20370661 20370662 17438146 17442976 20136829 19749080
    Theobromine-- 83-67-0targetantagonist17558310 3588607 17577101 12602592 15095008 17616786
    CaffeineCafeina (see all 7)58-08-2targetantagonist multitarget17558310 17577101 11752352 17616786
    OxtriphyllineCholine theophyllinate (see all 2)4499-40-5targetantagonist16357952 3588607
    TheophyllineDimethylxanthine (see all 6)58-55-9targetantagonist16357952 3588607
    4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol-- --target--10592235
    Defibrotide-- 83712-60-1target--8405101
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetantagonist2997628
    MefloquineMefloquine HCL (see all 2)53230-10-7targetantagonist18406614
    Pentoxifylline-- 6493-05-6targetantagonist19997047

    Selected IUPHAR Ligands for ADORA2A (A2A receptor) (see all 86)    About this table
    LigandTypeActionAffinityPubmed IDs
    SCH4421416
    AntagonistAntagonist8.4 - 10.320801028 11087559
    CGS 15943
    AntagonistAntagonist7.7 - 9.49459566 9933143 7775460 9179373
    apadenoson
    AgonistAgonist9.316518376
    SCH 58261
    AntagonistAntagonist8.3 - 9.29920286 9933143 9179373
    MRS1093
    AntagonistAntagonist9.28691424
    ZM-241385
    AntagonistAntagonist8.8 - 9.19933143
    preladenant
    AntagonistAntagonist9.0518221214
    [3H]SCH 58261
    AntagonistAntagonist8.6 - 99920286 9933143
    XAC
    AntagonistAntagonist8.4 - 99459566 9179373
    BIIB014
    AntagonistAntagonist8.8919072055

    Selected Novoseek inferred chemical compound relationships for ADORA2A gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5'-n-ethylcarboxamidoadenosine 91.9 17 8527267 (1), 8605954 (1), 8836153 (1), 9806342 (1) (see all 16)
    cgs21680 89.4 5 8088373 (1), 17575165 (1), 9128830 (1), 18384819 (1)
    regadenoson 86.3 9 18561509 (2), 17679059 (2), 16555687 (1), 17112296 (1) (see all 8)
    binodenoson 86 6 14734517 (3), 18561509 (1), 19920048 (1), 17531571 (1)
    istradefylline 85.4 5 14663020 (2), 15298067 (1), 17686497 (1), 15974638 (1)
    2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine 83.6 1 10676861 (1)
    8-(3-chlorostyryl)caffeine 83.5 9 8991804 (2), 8749024 (1), 8821736 (1), 8732271 (1)
    dpcpx 83 14 9806342 (2), 8028023 (1), 10513579 (1), 19552053 (1) (see all 10)
    dmpx 81.6 19 9435909 (3), 10676861 (2), 10714888 (1), 19552053 (1) (see all 10)
    4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino)ethyl)phenol 80.1 1 12909194 (1)

    2 PharmGKB related drug/compound annotations for ADORA2A gene    About this table
    Drug/compound PharmGKB Annotation
    caffeineCA  
    methotrexateCA  



    ADORA2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ADORA2A gene (5 alternative transcripts): 
    NM_000675.5  NM_001278497.1  NM_001278498.1  NM_001278499.1  NM_001278500.1  

    Unigene Cluster for ADORA2A:

    Adenosine A2a receptor
    Hs.197029  [show with all ESTs]
    Unigene Representative Sequence: NM_000675
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467385(uc010gun.1) ENST00000486351 ENST00000424232 ENST00000486108
    ENST00000464977 ENST00000444262(uc010guo.1) ENST00000496258 ENST00000337539(uc002zzx.3 uc002zzy.4 uc021wng.1 uc011ajs.2 uc010guq.3 uc010gup.3 uc003aab.3)
    ENST00000496497 ENST00000472248 ENST00000436735 ENST00000439591

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADORA2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADORA2A (see all 23):
    hsa-miR-34b* hsa-miR-3938 hsa-miR-15a hsa-miR-503 hsa-miR-339-5p hsa-miR-766 hsa-miR-424 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidADORA2A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADORA2A
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    OriGene ORF clones in mouse, rat for ADORA2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADORA2A (NM_000675)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADORA2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA2A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADORA2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADORA2A
      QuantiTect SYBR Green Assays in human, mouse, rat ADORA2A
      QuantiFast Probe-based Assays in human, mouse, rat ADORA2A

    Additional mRNA sequence: 

    AK123058.1 AK289871.1 AK301420.1 AK312946.1 AY136747.1 BC013780.1 BT006999.1 CR456367.1 
    EU036687.1 EU036688.1 EU036689.1 EU036690.1 EU036691.1 EU036692.1 EU036693.1 EU036694.1 
    M97370.1 

    10 DOTS entries:

    DT.100661170  DT.120642587  DT.314671  DT.120642847  DT.95310776  DT.120642633  DT.100022626  DT.100780535 
    DT.97841065  DT.432224 

    Selected AceView cDNA sequences (see all 83):

    AK123058 AY136747 BM556053 AW245531 BX462613 BX432706 BU738206 CR456367 
    BU689218 CR611621 BP368389 CR607919 BT006999 CK819042 BG107240 AW271618 
    R95738 NM_000675 BP366538 BM126464 AA905667 AA831171 BX428633 BF974282 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADORA2A expression in normal human tissues (normalized intensities)      ADORA2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGAGTAG
    ADORA2A Expression
    About this image


    ADORA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             Caudate nucleus   
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Thymus (Hematopoietic System)
    ADORA2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADORA2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.197029
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA2A: 
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADORA2A
    OriGene qSTAR qPCR primer pairs in human, mouse for ADORA2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADORA2A
    QuantiTect SYBR Green Assays in human, mouse, rat ADORA2A
    QuantiFast Probe-based Assays in human, mouse, rat ADORA2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADORA2A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora2a1 , 5 adenosine A2a receptor1, 5 84.46(n)1
    84.79(a)1
      10 (38.52 cM)5
    115401  NM_009630.21  NP_033760.21 
     753169435 
    chicken
    (Gallus gallus)
    Aves ADORA2A1 adenosine A2a receptor 71.94(n)
    73.99(a)
      427705  XM_425280.4  XP_425280.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADORA2A6
    adenosine A2a receptor
    60(a)
    1 ↔ 1
    GL343947.1(60391-64261)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adora2a1 adenosine A2a receptor 66.76(n)
    69.44(a)
      100127551  NM_001112927.1  NP_001106398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adora2ab1 adenosine A2a receptor b 67.81(n)
    70.19(a)
      566118  NM_001040036.1  NP_001035125.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97533 G-protein coupled receptor protein
    signaling pathway G-protein coupled
    receptor less
    36(a)   99D8   --
    worm
    (Caenorhabditis elegans)
    Secernentea ador-16
    Protein ADOR-1, isoform b (ador-1) mRNA, complete ...
    24(a)
    1 → many
    II(12497210-12502878) WBGene00011878


    ENSEMBL Gene Tree for ADORA2A (if available)
    TreeFam Gene Tree for ADORA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADORA2A gene
    ADORA12  GPR1192  ADORA2B2  
    Selected SIMAP similar genes for ADORA2A using alignment to 8 protein entries:     AA2AR_HUMAN (see all proteins) (see all similar genes):
    hA2aR    ADORA2B    HTR2B    HTR2A    GPR83    ADORA3
    HTR4    ADORA1    HCRTR2    ADRA2C    DRD2    GPR19
    HTR5A    ADRA1A    KISS1R    CHRM1    GPR176    OR51I2

    ADORA2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADORA2A (see all 77)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426691061,2
    --24821751(+) GCTCTC/TGTCTG 1 -- us2k10--------
    rs1167042921,2
    C,F--24821764(+) TTCTGG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1815588971,2
    --24821919(+) AGGGCC/TGGTGA 1 -- us2k10--------
    rs1176993221,2
    F--24821941(+) TGGAGC/TGGGGA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1855252031,2
    --24821977(+) GAGGGC/TCAGGG 1 -- us2k10--------
    rs1904475951,2
    --24822024(+) GAATGG/TTAGTT 1 -- us2k10--------
    rs1807544261,2
    --24822155(+) CCAAAA/GAAGGT 1 -- us2k10--------
    rs1460174611,2
    --24822190(+) TACCCA/GAGCCA 1 -- us2k10--------
    rs1858557381,2
    --24822264(+) GCAGCA/GCAAAC 1 -- us2k10--------
    rs770936801,2
    C,F--24822267(+) GCGCAA/GACAGA 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for ADORA2A (24813847 - 24838328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADORA2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    esv2724068CNV Deletion23290073
    nsv914634CNV Loss21882294
    nsv914633CNV Loss21882294
    nsv526567CNV Gain19592680
    nsv914629CNV Gain21882294
    nsv834160CNV Gain17160897
    nsv914599CNV Gain21882294
    nsv9884CNV Gain+Loss18304495
    nsv7350OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): ADORA2A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADORA2A
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102776    OMIM disorders: --

    Selected diseases for ADORA2A (see all 67):    About MalaCards
    acute encephalopathy with biphasic seizures and late reduced diffusion    carrion's disease    ischemia    migraine with aura
    panic disorder    syncope    sleep disorder    cerebritis
    conduct disorder    huntington's disease    goiter    diabetic neuropathy
    proliferative diabetic retinopathy    essential hypertension    parkinson's disease    tardive dyskinesia
    migraine    status epilepticus    pheochromocytoma    diabetic retinopathy

    2 diseases from the University of Copenhagen DISEASES database for ADORA2A:
    Parkinson's disease     Huntington's disease

    ADORA2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADORA2A gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 64.9 42 15033896 (4), 15719154 (2), 9345853 (2), 16022182 (2) (see all 33)
    basal ganglia disorders 55.2 1 18221214 (1)
    huntington disease 52.4 7 19591938 (1), 18536175 (1), 16184606 (1), 15689617 (1) (see all 7)
    neurodegenerative diseases 43.2 3 8991804 (1), 12958155 (1), 18536175 (1)
    catalepsy 43.2 3 9128830 (2)
    neurodegeneration 34.2 1 14720203 (1)
    pheochromocytoma 23.5 3 10400659 (1), 12590138 (1), 9920286 (1)
    schizophrenia 9.36 5 9029412 (2), 15719154 (2)
    goiter 8.98 2 12740015 (1)
    panic disorder 7.84 4 15774265 (2), 9491818 (1), 11515749 (1)

    Genetic Association Database (GAD): ADORA2A
    Human Genome Epidemiology (HuGE) Navigator: ADORA2A (35 documents)

    Export disorders for ADORA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADORA2A gene, integrated from 10 sources (see all 579):
    (articles sorted by number of sources associating them with ADORA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. (PubMed id 17616786)1, 4, 7, 9 Cornelis M.C....Campos H. (Am. J. Clin. Nutr. 2007)
    2. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. (PubMed id 18305461)1, 4, 9 Childs E....de Wit H. (Neuropsychopharmacology 2008)
    3. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. (PubMed id 17329997)1, 4, 9 RActey J.V....Landolt H.P. (Clin. Pharmacol. Ther. 2007)
    4. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4, 9 Kim S.H....Park H.S. (Respir Med 2009)
    5. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)1, 4, 9 Wright K....Griffiths L.R. (J. Hypertens. 2004)
    6. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. (PubMed id 7775460)1, 2, 9 Kim J.... Jacobson K.A. (J. Biol. Chem. 1995)
    7. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. (PubMed id 18832607)1, 2, 9 Jaakola V.-P.... Stevens R.C. (Science 2008)
    8. A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease. (PubMed id 19591938)1, 4, 9 Dhaenens C.M....Blum D. (Neurobiol. Dis. 2009)
    9. The 1976C&gt;T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. (PubMed id 17558310)1, 7, 9 Riksen N.P....Rongen G.A. (Pharmacogenet. Genomics 2007)
    10. Association study of A2a adenosine receptor genetic polymorphism in panic disorder. (PubMed id 15774265)1, 4, 9 Lam P....Tsai S.J. (Neurosci. Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 135 HGNC: 263 AceView: ADORA2A Ensembl:ENSG00000128271 euGenes: HUgn135
    ECgene: ADORA2A Kegg: 135 H-InvDB: ADORA2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADORA2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADORA2A gene:
    Search GeneIP for patents involving ADORA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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