Aliases for ADORA2A Gene
External Ids for ADORA2A Gene
Previous HGNC Symbols for ADORA2A Gene
Previous GeneCards Identifiers for ADORA2A Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
GeneCards Summary for ADORA2A Gene
ADORA2A (Adenosine A2a Receptor) is a Protein Coding gene. Diseases associated with ADORA2A include acute encephalopathy with biphasic seizures and late reduced diffusion and ischemia. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is GPR119.
UniProtKB/Swiss-Prot for ADORA2A Gene
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes, blood platelets, striatopallidal GABAergic neurons and the olfactory bulb. Lower expression levels are also found in the heart, lungs and blood vessels. A2A receptors mediate a sustained cardioprotective function during cardiac ischemia, inhibit neutrophil degranulation in neutrophil-mediated tissue injury and have been implicated in both neuroprotective and neurodegenerative effects. The human A2A receptor gene is localized on chromosome 22 (22q11.23).