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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADORA2A Gene

protein-coding   GIFtS: 71
GCID: GC22P024813

Adenosine A2a Receptor


(Previous symbol: ADORA2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosine A2a Receptor1 2
ADORA21 2 3
A2aR2
RDC82
Adenosine Receptor A2a2
Adenosine Receptor Subtype A2a2

External Ids:    HGNC: 2631   Entrez Gene: 1352   Ensembl: ENSG000001282717   OMIM: 1027765   UniProtKB: P292743   

Export aliases for ADORA2A gene to outside databases

Previous GC identifers: GC22P021519 GC22P023148 GC22P023153 GC22P022997 GC22P007773


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADORA2A Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR)
superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins
that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an
adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially
interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an
important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood
flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such
as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript
variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and
coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is
thought to be non-coding. (provided by RefSeq, Jun 2013)

GeneCards Summary for ADORA2A Gene: 
ADORA2A (adenosine A2a receptor) is a protein-coding gene. Diseases associated with ADORA2A include carrion's disease, and ischemia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include alpha-actinin binding and protein heterodimerization activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
cyclase

summary for ADORA2A Gene:
Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also
includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes,
blood platelets, striatopallidal GABAergic neurons and the olfactory bulb. Lower expression levels are also
found in the heart, lungs and blood vessels. A2A receptors mediate a sustained cardioprotective function
during cardiac ischemia, inhibit neutrophil degranulation in neutrophil-mediated tissue injury and have been
implicated in both neuroprotective and neurodegenerative effects. The human A2A receptor gene is localized
on chromosome 22 (22q11.23).

Gene Wiki entry for ADORA2A (Adenosine A2A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADORA2A gene promoter:
         SRF   STAT1   Pax-5   SRF (504 AA)   NF-kappaB   GATA-2   PPAR-alpha   NF-kappaB2   Zic1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ADORA2A promoter sequence
   Search SABiosciences Chromatin IP Primers for ADORA2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

ADORA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA2A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024813:  view genomic region     (about GC identifiers)

Start:
24,813,847 bp from pter      End:
24,838,328 bp from pter
Size:
24,482 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274 (See protein sequence)
Recommended Name: Adenosine receptor A2a  
Size: 412 amino acids; 44707 Da
Subunit: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with
DRD4
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA58356.1; Type=Erroneous initiation;
6/14 PDB 3D structures from and Proteopedia for ADORA2A (see all 14):
1MMH (3D)        1UPE (3D)        2YDO (3D)        2YDV (3D)        3EML (3D)        3PWH (3D)    
Secondary accessions: B2R7E0

Explore the universe of human proteins at neXtProt for ADORA2A: NX_P29274

Explore proteomics data for ADORA2A at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29274

  • ADORA2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADORA2A Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_000666.2  NP_001265426.1  NP_001265427.1  NP_001265428.1  NP_001265429.1  

    ENSEMBL proteins: 
     ENSP00000404497   ENSP00000473799   ENSP00000474895   ENSP00000414802   ENSP00000474097  
     ENSP00000336630   ENSP00000475000   ENSP00000397071   ENSP00000400190  
    Reactome Protein details: P29274
    Human Recombinant Protein Products for ADORA2A: 
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    Novus Biologicals ADORA2A Proteins
    Novus Biologicals ADORA2A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IMP--
    GO:0012505endomembrane system IEA--
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane TAS10051547

    ADORA2A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADORA: GPCR / Class A : Adenosine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: A2A receptor 
    Adenosine receptors

    4 InterPro protein domains:
     IPR001634 Adenosn_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001513 Adeno_A2A_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P29274

    ProtoNet protein and cluster: P29274

    2 Blocks protein domains:
    IPB001513 Adenosine A2A receptor signature
    IPB001634 Adenosine receptor signature


    UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274
    Domain: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to
    the cell surface
    Similarity: Belongs to the G-protein coupled receptor 1 family


    ADORA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AA2AR_HUMAN, P29274
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl
    cyclase

         Genatlas biochemistry entry for ADORA2A:
    adenosine receptor A2A,mainly expressed in the basal ganglia and immune tissues,G protein coupled receptor
    superfamily,activating adenylate cyclase

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IDA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI11571652
    GO:0019899enzyme binding IPI16339847
    GO:0031802type 5 metabotropic glutamate receptor binding IEA--
         
    ADORA2A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADORA2A:
     Decreased substrate adherent c  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adora2a):
     behavior/neurological  cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  muscle  nervous system  respiratory system 
     vision/eye 

    ADORA2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADORA2A: Adora2atm1Jfc Adora2atm1Map Adora2atm1.1Dyj

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADORA2A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADORA2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADORA2A 

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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ADORA2A (see all 23):
    hsa-miR-34b* hsa-miR-3938 hsa-miR-15a hsa-miR-503 hsa-miR-339-5p hsa-miR-766 hsa-miR-424 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidADORA2A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADORA2A (NM_000675)
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                         Customized lentivirus expression plasmids for stable overexpression of ADORA2A 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADORA2A About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors0.75
    Adenosine P1 receptors0.36
    Nucleotide GPCRs0.59
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4NGF-independant TRKA activation
    NGF-independant TRKA activation0.83
    Activation of TRKA receptors0.83
    5Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ADORA2A
        Development A2A receptor signaling
    Signal transduction IP3 signaling


    2 GeneGo (Thomson Reuters) Pathways for ADORA2A
        Development A2A receptor signaling
    Signal transduction IP3 signaling

    5 BioSystems Pathways for ADORA2A
        GPCRs, Other
    Monoamine Transport
    GPCRs, Class A Rhodopsin-like
    HIF-2-alpha transcription factor network
    Nucleotide GPCRs


    5/12        Reactome Pathways for ADORA2A (see all 12)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    NGF signalling via TRKA from the plasma membrane


    4         Kegg Pathways  (Kegg details for ADORA2A):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction
    Alcoholism


    ADORA2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADORA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/86 Interacting proteins for ADORA2A (P292741, 2, 3 ENSP000003366304) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621581, 3EBI-2902702,EBI-397435 I2D: score=3 
    CALM3P621581, 3EBI-2902702,EBI-397435 I2D: score=3 
    ADORA1P305421, 3, ENSP000003085494EBI-2902702,EBI-2903663 I2D: score=4 STRING: ENSP00000308549
    CYTH2Q994181, 3, ENSP000004082364EBI-2902702,EBI-448974 I2D: score=3 STRING: ENSP00000408236
    USP4Q131071, 3, ENSP000002655604EBI-2902702,EBI-723290 I2D: score=2 STRING: ENSP00000265560
    About this table

    Gene Ontology (GO): 5/57 biological process terms (GO ID links to tree view) (see all 57):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001973adenosine receptor signaling pathway ----
    GO:0001975response to amphetamine IEA--
    GO:0006171cAMP biosynthetic process TAS10899090
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ADORA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADORA2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ADORA2A

    Compounds for ADORA2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SCH 442416 Very selective, high affinity A2A antagonist [316173-57-6]
    ANR 94Adenosine A2A antagonist[634924-89-3]
    CGS 21680 hydrochlorideA2A agonist[124182-57-6]
    SCH 58261 Potent, highly selective A2A antagonist [160098-96-4]
    ZM 241385 Potent, highly selective A2A antagonist [139180-30-6]

    3 HMDB Compounds for ADORA2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    CaffeineHycomine (see all 15)58-08-2--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--

    10/11 DrugBank Compounds for ADORA2A (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 16339914 20370661 20370662 17438146 17442976 20136829 19749080
    Theobromine-- 83-67-0targetantagonist17558310 3588607 17577101 12602592 15095008 17616786
    CaffeineCafeina (see all 7)58-08-2targetantagonist multitarget17558310 17577101 11752352 17616786
    OxtriphyllineCholine theophyllinate (see all 2)4499-40-5targetantagonist16357952 3588607
    TheophyllineDimethylxanthine (see all 6)58-55-9targetantagonist16357952 3588607
    4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol-- --target--10592235
    Defibrotide-- 83712-60-1target--8405101
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetantagonist2997628
    MefloquineMefloquine HCL (see all 2)53230-10-7targetantagonist18406614
    Pentoxifylline-- 6493-05-6targetantagonist19997047

    10/86 IUPHAR Ligands for ADORA2A (A2A receptor) (see all 86)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SCH4421416
    AntagonistAntagonist8.4 - 10.320801028 11087559
    CGS 15943
    AntagonistAntagonist7.7 - 9.49459566 9933143 7775460 9179373
    apadenoson
    AgonistAgonist9.316518376
    SCH 58261
    AntagonistAntagonist8.3 - 9.29920286 9933143 9179373
    MRS1093
    AntagonistAntagonist9.28691424
    ZM-241385
    AntagonistAntagonist8.8 - 9.19933143
    preladenant
    AntagonistAntagonist9.0518221214
    [3H]SCH 58261
    AntagonistAntagonist8.6 - 99920286 9933143
    XAC
    AntagonistAntagonist8.4 - 99459566 9179373
    BIIB014
    AntagonistAntagonist8.8919072055

    10/94 Novoseek inferred chemical compound relationships for ADORA2A gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5'-n-ethylcarboxamidoadenosine 91.9 17 8527267 (1), 8605954 (1), 8836153 (1), 9806342 (1) (see all 16)
    cgs21680 89.4 5 8088373 (1), 17575165 (1), 9128830 (1), 18384819 (1)
    regadenoson 86.3 9 18561509 (2), 17679059 (2), 16555687 (1), 17112296 (1) (see all 8)
    binodenoson 86 6 14734517 (3), 18561509 (1), 19920048 (1), 17531571 (1)
    istradefylline 85.4 5 14663020 (2), 15298067 (1), 17686497 (1), 15974638 (1)
    2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine 83.6 1 10676861 (1)
    8-(3-chlorostyryl)caffeine 83.5 9 8991804 (2), 8749024 (1), 8821736 (1), 8732271 (1)
    dpcpx 83 14 9806342 (2), 8028023 (1), 10513579 (1), 19552053 (1) (see all 10)
    dmpx 81.6 19 9435909 (3), 10676861 (2), 10714888 (1), 19552053 (1) (see all 10)
    4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino)ethyl)phenol 80.1 1 12909194 (1)

    2 PharmGKB related drug/compound annotations for ADORA2A gene    About this table
    Drug/compound PharmGKB Annotation
    caffeineCA  
    methotrexateCA  

    Search CenterWatch for drugs/clinical trials and news about ADORA2A / AA2AR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADORA2A gene (5 alternative transcripts): 
    NM_000675.5  NM_001278497.1  NM_001278498.1  NM_001278499.1  NM_001278500.1  

    Unigene Cluster for ADORA2A:

    Adenosine A2a receptor
    Hs.197029  [show with all ESTs]
    Unigene Representative Sequence: NM_000675
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467385(uc010gun.1) ENST00000486351 ENST00000424232 ENST00000486108
    ENST00000464977 ENST00000444262(uc010guo.1) ENST00000496258 ENST00000337539(uc002zzx.3 uc002zzy.4 uc021wng.1 uc011ajs.2 uc010guq.3 uc010gup.3 uc003aab.3)
    ENST00000496497 ENST00000472248 ENST00000436735 ENST00000439591

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    Additional mRNA sequence: 

    AK123058.1 AK289871.1 AK301420.1 AK312946.1 AY136747.1 BC013780.1 BT006999.1 CR456367.1 
    EU036687.1 EU036688.1 EU036689.1 EU036690.1 EU036691.1 EU036692.1 EU036693.1 EU036694.1 
    M97370.1 

    10 DOTS entries:

    DT.100661170  DT.120642587  DT.314671  DT.120642847  DT.95310776  DT.120642633  DT.100022626  DT.100780535 
    DT.97841065  DT.432224 

    24/83 AceView cDNA sequences (see all 83):

    BM556053 BU689218 AW245531 BX462613 BU738206 AK123058 BP368389 BX432706 
    CR611621 AY136747 CR456367 CR607919 BG150557 BF512774 AI823538 BE044575 
    CF147807 CK819042 BT006999 BI551288 BM917693 BG759406 BF974282 CD367743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADORA2A expression in normal human tissues (normalized intensities)      ADORA2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGAGTAG
    ADORA2A Expression
    About this image


    ADORA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             Caudate nucleus   
     
     Thymus (Hematopoietic System)
             Thymus   
     
     Endothelium (Cardiovascular System)
             PureStem endothelial progenitor 30-SM2-1
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Uncategorized (Uncategorized)
             PureStem progenitor RP1-MV2-6

    See ADORA2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADORA2A

    SOURCE GeneReport for Unigene cluster: Hs.197029
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADORA2A: 
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADORA2A gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora2a1 , 5 adenosine A2a receptor1, 5 84.37(n)1
    84.79(a)1
      10 (38.52 cM)5
    115401  NM_009630.21  NP_033760.21 
     753169435 
    chicken
    (Gallus gallus)
    Aves ADORA2A1 adenosine A2a receptor 71.67(n)
    73.99(a)
      427705  XM_425280.3  XP_425280.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADORA2A6
    --
    Uncharacterized protein
    56(a)
    37(a)
    1 ↔ 1
    possible ortholog
    GL343947.1(60391-64261)
    GL343568.1(96739-97722)
    zebrafish
    (Danio rerio)
    Actinopterygii adora2aa1 adenosine A2a receptor a 69.52(n)
    70.21(a)
      561701  NM_001039815.1  NP_001034904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97533
    AdoR1
    G-protein coupled receptor protein
    signaling pathway more3
    Adenosine receptor1
    36(a)3
    55(n)1
    41.43(a)1
      99D83
    435831  NM_143515.21  NP_651772.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ador-16
    Protein ADOR-1, isoform b
    22(a)
    1 → many
    II(12497210-12502878)


    ENSEMBL Gene Tree for ADORA2A (if available)
    TreeFam Gene Tree for ADORA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADORA2A gene
    ADORA12  GPR1192  ADORA2B2  ADORA32  
    12 SIMAP similar genes for ADORA2A using alignment to 5 protein entries:     AA2AR_HUMAN (see all proteins):
    hA2aR    ADORA2B    HTR2B    GPR83    HTR4    ADORA1
    ADORA3    ADRA2C    DRD2    HTR5A    CHRM1    HRH2

    ADORA2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/77 SNPs in ADORA2A are shown (see all 77)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0118354
    ----see VAR_0118352 A V mis40--------
    VAR_0034514
    ----see VAR_0034512 G R mis40--------
    VAR_0118364
    ----see VAR_0118362 R H mis40--------
    rs1426691061,2
    --24821751(+) GCTCTC/TGTCTG 1 -- us2k10--------
    rs1167042921,2
    C,F--24821764(+) TTCTGG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1815588971,2
    --24821919(+) AGGGCC/TGGTGA 1 -- us2k10--------
    rs1176993221,2
    F--24821941(+) TGGAGC/TGGGGA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1855252031,2
    --24821977(+) GAGGGC/TCAGGG 1 -- us2k10--------
    rs1904475951,2
    --24822024(+) GAATGG/TTAGTT 1 -- us2k10--------
    rs1807544261,2
    --24822155(+) CCAAAA/GAAGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADORA2A (24813847 - 24838328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADORA2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    esv2724068CNV Deletion23290073
    nsv914634CNV Loss21882294
    nsv914633CNV Loss21882294
    nsv526567CNV Gain19592680
    nsv914629CNV Gain21882294
    nsv834160CNV Gain17160897
    nsv914599CNV Gain21882294
    nsv9884CNV Gain+Loss18304495
    nsv7350OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): ADORA2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 102776    OMIM disorders: --

    20/57 diseases for ADORA2A (see all 57):    About MalaCards
    carrion's disease    ischemia    syncope    migraine with aura
    panic disorder    sleep disorder    conduct disorder    huntington's disease
    diabetic neuropathy    goiter    essential hypertension    parkinson's disease
    proliferative diabetic retinopathy    migraine    pheochromocytoma    diabetic retinopathy
    mood disorder    albinism    autism spectrum disorder    vaccinia

    2 diseases from the University of Copenhagen DISEASES database for ADORA2A:
    Parkinson's disease     Huntington's disease

    ADORA2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/31 Novoseek inferred disease relationships for ADORA2A gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 64.9 42 15033896 (4), 15719154 (2), 9345853 (2), 16022182 (2) (see all 33)
    basal ganglia disorders 55.2 1 18221214 (1)
    huntington disease 52.4 7 19591938 (1), 18536175 (1), 16184606 (1), 15689617 (1) (see all 7)
    neurodegenerative diseases 43.2 3 8991804 (1), 12958155 (1), 18536175 (1)
    catalepsy 43.2 3 9128830 (2)
    neurodegeneration 34.2 1 14720203 (1)
    pheochromocytoma 23.5 3 10400659 (1), 12590138 (1), 9920286 (1)
    schizophrenia 9.36 5 9029412 (2), 15719154 (2)
    goiter 8.98 2 12740015 (1)
    panic disorder 7.84 4 15774265 (2), 9491818 (1), 11515749 (1)

    Genetic Association Database (GAD): ADORA2A
    Human Genome Epidemiology (HuGE) Navigator: ADORA2A (35 documents)

    Export disorders for ADORA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADORA2A gene, integrated from 9 sources (see all 568):
    (articles sorted by number of sources associating them with ADORA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. (PubMed id 17616786)1, 4, 7, 9 Cornelis M.C....Campos H. (2007)
    2. Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety. (PubMed id 18305461)1, 4, 9 Childs E....de Wit H. (2008)
    3. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. (PubMed id 17329997)1, 4, 9 Retey J.V....Landolt H.P. (2007)
    4. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4, 9 Kim S.H....Park H.S. (2008)
    5. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)1, 4, 9 Wright K....Griffiths L.R. (2004)
    6. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. (PubMed id 7775460)1, 2, 9 Kim J.... Jacobson K.A. (1995)
    7. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. (PubMed id 18832607)1, 2, 9 Jaakola V.P....Stevens R.C. (2008)
    8. A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease. (PubMed id 19591938)1, 4, 9 Dhaenens C.M....Blum D. (2009)
    9. The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. (PubMed id 17558310)1, 7, 9 Riksen N.P....Rongen G.A. (2007)
    10. Association study of A2a adenosine receptor genetic polymorphism in panic disorder. (PubMed id 15774265)1, 4, 9 Lam P....Tsai S.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135 HGNC: 263 AceView: ADORA2A Ensembl:ENSG00000128271 euGenes: HUgn135
    ECgene: ADORA2A Kegg: 135 H-InvDB: ADORA2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADORA2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADORA2A gene:
    Search GeneIP for patents involving ADORA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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