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ADORA2A Gene

protein-coding GIFtS: 68

GC22P022997

adenosine A2a receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADORA2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADORA2 ^², ³
RDC8 ^¹, ²
hA2aR ^²

Descriptions
adenosine A2 receptor ^²
adenosine A2a receptor ^²
adenosine receptor subtype A2a ^²

External Ids
HGNC: 263¹
Entrez Gene: 135²
UniProtKB: P29274³
Ensembl: ENSG00000128271⁷

Search outside databases for aliases for ADORA2A gene

Previous GC identifers: GC22P021519 GC22P023148 GC22P023153

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADORA2A:

This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity

of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins

which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and

platelets and it is a major target of caffeine. [provided by RefSeq]

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

activate adenylyl cyclase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADORA2A gene

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

ADORA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P022997: (about GC identifiers)

Start:	22,996,866 bp from pter
End:	23,168,325 bp from pter
Size:	171,460 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274 (See protein sequence)

Recommended Name: Adenosine receptor A2a

Size: 412 amino acids; 44707 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1MMH (3D)

1UPE (3D)

3EML (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000666.2

ENSEMBL proteins:

ENSP00000336630 ENSP00000351480 ENSP00000385337

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADORA2A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Adenosine Receptor A2a)
	Human Recombinant Proteins from Abnova (ADORA2A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	10051547
GO:0005886	plasma membrane	TAS	8794889 10051547
GO:0005887	integral to plasma membrane	TAS	8794889

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Antibodies for ADORA2A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADORA2A
	Sigma-Aldrich Antibodies for ADORA2A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Adenosine Receptor A2a), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADORA2A)
	Novus Biologicals Antibodies for ADORA2A

Assays for ADORA2A:

	Invitrogen Assays for ADORA2A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P29274

ProtoNet protein and cluster: P29274

2 Blocks protein families:

IPB001513 Adenosine A2A receptor signature

IPB001634 Adenosine receptor signature

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000675

Applied Biosystems Silencer® siRNAs for ADORA2A

Sigma-Aldrich siRNA and siRNA Panels for ADORA2A

Sigma-Aldrich shRNA Panels and shRNA for ADORA2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADORA2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000675
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000675
untagged cDNA clones in CMV expression vector (see all 2): NM_000675

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000675

UniProtKB/Swiss-Prot: AA2AR_HUMAN, P29274

Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which

activate adenylyl cyclase

Genatlas biochemistry entry for ADORA2A:

adenosine receptor A2A,mainly expressed in the basal ganglia and immune tissues,G protein coupled

receptor superfamily,activating adenylate cyclase

8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adora2a):

	behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism
immune system	nervous system	touch/vibrissae

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001609	adenosine receptor activity, G-protein coupled	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADORA2A (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks ADORA2A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADORA2A

5/31 Interacting proteins for ADORA2A (ENSP00000351480³ P29274²) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADORA2A	P29274²	MINT-6699346 MINT-6700472 MINT-6797129 MINT-6797142 MINT-6797156 MINT-6699330
NAMPT	P43490²	MINT-6538741
ADA	ENSP00000361965³	STRING (score=.969)
NTRK1	ENSP00000351486³	STRING (score=.926)
NTRK2	ENSP00000365387³	STRING (score=.919)

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006171	cAMP biosynthetic process	TAS	10899090
GO:0006909	phagocytosis	TAS	8360491
GO:0006915	apoptosis	TAS	7818494
GO:0006954	inflammatory response	TAS	8360491
GO:0006968	cellular defense response	TAS	10051547

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADORA2A:

Mixed Agonist/Antagonist Antagonist Agonist Inhibitor Ligand

Compounds for ADORA2A available from Tocris Bioscience

Compound	Action	CAS number
SCH 442416	Very selective, high affinity A2A antagonist	[316173-57-6]
SCH 58261	Potent, highly selective A2A antagonist	[160098-96-4]
PSB 603	Highly selective A2B antagonist
ZM 241385	Potent, highly selective A2A antagonist	[139180-30-6]

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10/51 Novoseek chemical compound relationships for ADORA2A gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cgs21680	89.39	5	8088373 (1), 17575165 (1), 9128830 (1), 18384819 (1)
regadenoson	86.81	8	18561509 (2), 17679059 (2), 16555687 (1), 17112296 (1) (see all 7)
istradefylline	85.47	5	14663020 (2), 15298067 (1), 17686497 (1), 15974638 (1)
binodenoson	84.13	5	14734517 (3), 18561509 (1), 17531571 (1)
8-(3-chlorostyryl)caffeine	84.12	9	8991804 (2), 8749024 (1), 8821736 (1), 8732271 (1)
dpcpx	82.58	13	9806342 (2), 8028023 (1), 10513579 (1), 1694546 (1) (see all 9)
4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino)ethyl)phenol	81.00	1	12909194 (1)
kf 17837	80.29	7	8088373 (2), 8045270 (2), 8901821 (1)
dmpx	80.20	16	9435909 (3), 10676861 (2), 10714888 (1), 10340308 (1) (see all 9)
n6-cyclopentyladenosine	78.77	8	9806342 (1), 10676861 (1), 7930619 (1), 8808787 (1) (see all 6)

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3 PharmGKB drug compound relationships for ADORA2A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
caffeine	FA	10728760 12106498
methotrexate	FA	12528125 10728760 12106498
theophylline	FA	10728760

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADORA2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADORA2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000675

Sigma-Aldrich siRNA and siRNA Panels for ADORA2A

Sigma-Aldrich shRNA Panels and shRNA for ADORA2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000675

REFSEQ mRNAs for ADORA2A gene:

NM_000675.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000675

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000675
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000675
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000675

Additional cDNA sequence:

AK123058.1 AK289871.1 AK301420.1 AK312946.1 AY136747.1 BC013780.1 BT006999.1 CR456367.1

CR607919.1 CR611621.1 EU036687.1 EU036688.1 EU036689.1 EU036690.1 EU036691.1 EU036692.1

EU036693.1 EU036694.1 M97370.1

10 DOTS entries:

DT.100661170 DT.120642587 DT.314671 DT.95310776 DT.120642847 DT.120642633 DT.100022626 DT.100780535

DT.97841065 DT.432224

24/83 AceView cDNA sequences (see all 83 ):

CR607919 BU689218 BX432706 AK123058 BU738206 AY136747 BM556053 CR611621

AW245531 BP368389 CR456367 BX462613 AW274391 BM543787 BP366538 M97370

AW271618 AA429914 BG107240 CD367743 BG686029 BI224985 CK819042 CA307692

highest scoring ESTs for ADORA2A:

AA761679 AA772974 AA831171 AA884414 AA905667 AA905668 AA974478 AA992777 AI000025 AI250766

Unigene Cluster for ADORA2A:

Adenosine A2a receptor

Hs.197029 [show with all ESTs]

Unigene Representative Sequence: NM_000675

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000337539 ENST00000358654 ENST00000406084

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADORA2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADORA2A

¹ / ² / ³

4 probe-sets matching ADORA2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32114_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.93	S46950	0.80	0.88	0.84	1
32115_r_at²^{, 3}	U95-A	1	1.00	1.00	0.77	1.07	X68486	0.60	0.62	0.61	1
205013_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000675	0.60	0.83	0.73	1
205013_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADORA2A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: TGCTGAGTAG

SOURCE GeneReport for Unigene cluster: Hs.197029
Expression variation in blood from EXPOLDB for ADORA2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADORA2A gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADORA2A¹	--	adenosine A2a receptor	91.02(n) 93.2(a)	403960 NM_001003278.1 NP_001003278.1
chimpanzee (Pan troglodytes)	ADORA2A¹	--	adenosine A2a receptor	99.51(n) 99.76(a)	458714 XM_515035.2 XP_515035.2
cow (Bos taurus)	ADORA2A¹	--	adenosine A2a receptor	84.69(n) 84.01(a)	617828 XM_870153.2 XP_875246.2
rat (Rattus norvegicus)	Adora2a¹	--	adenosine A2a receptor	83.62(n) 84.29(a)	25369 NM_053294.3 NP_445746.3
mouse (Mus musculus)	Adora2a^{1, 5}	10⁵	adenosine A2a receptor^{1, 5}	84.37(n)¹ 84.79(a)¹	11540¹ NM_009630.2¹ NP_033760.2¹ AK037787⁵ AK206618⁵ (see all 16)

About this table Species with no ortholog for ADORA2A

ENSEMBL Gene Tree for ADORA2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADORA2A gene

GPR119² ADORA2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/93 NCBI SNPs in ADORA2A are shown (see all 93 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 63)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12484115^1,2	C,F,H	23152446(+)	`GAAGGG/ATCTGG`	1	--	ng5¹		4		EU EA WA	418
	rs4530^1,2	C,F,H	23159521(+)	`GGCGGC/TGGCCG`	1	A/V	mis¹ ese³		15		MN NA EU EA WA	1496
	rs7285057^1,2	F,H	23152663(+)	`CTCCAT/CGGATC`	1	--	ng5¹		4		EU EA WA	408
	rs4990^1,2	C,H	23167117(+)	`CTTCCG/ACAAGA`	1	H/R	mis¹ ese³		7		MN EU EA WA	842
	rs5760413^1,2	C,H	23153325(+)	`TTGCAG/ACCACC`	1	--	ng5¹		5		EU EA WA	598
	rs4992^1,2	H	23167752(+)	`ATCTGG/TAAGCA`	1	--	ut3¹		6		MN EU EA WA	670
	rs17650937^1,2	C,F,H	23167103(+)	`GAGTTC/TCGCCA`	1	F/F	syn¹		7		NA EU EA WA	562
	rs4991^1,2	C,F,H	23167262(+)	`GCCAAC/TGGCAG`	1	N/N	syn¹ ese³		9		MN NA EU EA WA	806
	rs8192446^1,2	C,F,H	23166650(+)	`TGGAAC/TAACTG`	1	N/N	syn¹		7		EU EA WA NA	552
--	rs5751876^1,2	A,C	23167301(+)	`GGCTAC/TGCCCT`	1	Y/Y	syn¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ADORA2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102776

10/30 Novoseek disease relationships for ADORA2A gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	63.39	35	15033896 (4), 15719154 (2), 9345853 (2), 16022182 (2) (see all 26)
basal ganglia disorders	56.68	1	18221214 (1)
huntington disease	51.36	6	18536175 (1), 16184606 (1), 15689617 (1), 17303312 (1) (see all 6)
neurodegenerative diseases	39.71	3	8991804 (1), 12958155 (1), 18536175 (1)
catalepsy	33.41	3	9128830 (2)
neurodegeneration	32.42	1	14720203 (1)
pheochromocytoma	16.12	3	10400659 (1), 12590138 (1), 9920286 (1)
schizophrenia	12.23	5	9029412 (2), 15719154 (2)
goiter	10.93	2	12740015 (1)
panic disorder	9.94	4	15774265 (2), 9491818 (1), 11515749 (1)

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1 PharmGKB disease relationship for ADORA2A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Arthritis, Experimental	FA	10728760

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Human Gene Mutation Database: ADORA2A
Genetic Association Database: ADORA2A
Human Genome Epidemiology Navigator: ADORA2A (18 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/371 PubMed articles for ADORA2A gene (see all 371 ):

Association study of A2a adenosine receptor genetic polymorphism in panic disorder. (PubMed id 15774265)^{1, 3, 6} Lam P....Tsai S.J. (2005)
The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)^{1, 3, 6} Wright K....Griffiths L.R. (2004)
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. (PubMed id 7775460)^{1, 3, 4} Kim J.... Jacobson K.A. (1995)
Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PubMed id 1662665)^{1, 2, 3} Libert F....Mattei M.G. (1991)
Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PubMed id 11515749)^{1, 3, 6} Yamada K....Yoshikawa T. (2001)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. (PubMed id 14666117)^{3, 6} Hamilton S.P....Knowles J.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. (PubMed id 12825092)^{3, 6} Alsene K....de Wit H. (2003)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{3, 4} Cargill M....Lander E.S. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 135	HGNC: 263	AceView: ADORA2A	Ensembl:ENSG00000128271	euGenes: HUgn135
ECgene: ADORA2A	H-InvDB: ADORA2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADORA2A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADORA2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADORA2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADORA2A		Antibodies for ADORA2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADORA2A		Small molecules for ADORA2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADORA2A)
	Antibodies (ADORA2A)
	Chimera RNAi (ADORA2A)
	Custom Service for Mouse Mab
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	Recombinant Proteins (Adenosine Receptor A2a)
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ADORA2A Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ADORA2A

Summaries
for ADORA2A

Genomic Location
for ADORA2A

Proteins
for ADORA2A

Protein Domains/
Families
for ADORA2A

Gene Function
for ADORA2A

Pathways & Interactions
for ADORA2A

Drugs & Compounds
for ADORA2A

Transcripts
for ADORA2A

Expression
for ADORA2A

Orthologs
for ADORA2A

Paralogs
for ADORA2A

SNPs/Variants
for ADORA2A

Disorders & Mutations
for ADORA2A

Medical News
for ADORA2A

Publications
for ADORA2A

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Genome Databases showing ADORA2A

Other Databases showing ADORA2A

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Licensable Technologies
for ADORA2A

Services
for ADORA2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADORA2A Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ADORA2A

Summariesfor ADORA2A

Genomic Locationfor ADORA2A

Proteinsfor ADORA2A

Protein Domains/Familiesfor ADORA2A

Gene Functionfor ADORA2A

Pathways & Interactionsfor ADORA2A

Drugs & Compoundsfor ADORA2A

Transcriptsfor ADORA2A

Expression for ADORA2A

Orthologsfor ADORA2A

Paralogsfor ADORA2A

SNPs/Variantsfor ADORA2A

Disorders & Mutationsfor ADORA2A

Medical Newsfor ADORA2A

Publicationsfor ADORA2A

Search for ADORA2A

Genome Databases showing ADORA2A

Other Databases showing ADORA2A

Specialized Databases showing ADORA2A

Licensable Technologiesfor ADORA2A

Servicesfor ADORA2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADORA2A

Summaries
for ADORA2A

Genomic Location
for ADORA2A

Proteins
for ADORA2A

Protein Domains/
Families
for ADORA2A

Gene Function
for ADORA2A

Pathways & Interactions
for ADORA2A

Drugs & Compounds
for ADORA2A

Transcripts
for ADORA2A

Expression
for ADORA2A

Orthologs
for ADORA2A

Paralogs
for ADORA2A

SNPs/Variants
for ADORA2A

Disorders & Mutations
for ADORA2A

Medical News
for ADORA2A

Publications
for ADORA2A

Licensable Technologies
for ADORA2A

Services
for ADORA2A