Aliases for ADORA1 Gene
External Ids for ADORA1 Gene
Previous GeneCards Identifiers for ADORA1 Gene
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADORA1 Gene
ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include brain ischemia and retinal ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and G-protein beta/gamma-subunit complex binding. An important paralog of this gene is GPR119.
UniProtKB/Swiss-Prot for ADORA1 Gene
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. They display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and esophagus.