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Aliases for ADORA1 Gene

Aliases for ADORA1 Gene

  • Adenosine A1 Receptor 2 3 5
  • Adenosine A1 Receptor Variant 1 3
  • Adenosine A1 Receptor Variant 2 3
  • RDC7 3

External Ids for ADORA1 Gene

Previous GeneCards Identifiers for ADORA1 Gene

  • GC01P200742
  • GC01P198489
  • GC01P199526
  • GC01P200348
  • GC01P199791
  • GC01P201326
  • GC01P174262

Summaries for ADORA1 Gene

Entrez Gene Summary for ADORA1 Gene

  • The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA1 Gene

ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include Ischemia and Brain Ischemia. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA1 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Tocris Summary for ADORA1 Gene

  • The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.

Gene Wiki entry for ADORA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA1 Gene

Genomics for ADORA1 Gene

Regulatory Elements for ADORA1 Gene

Enhancers for ADORA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADORA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADORA1 Gene

Chromosome:
1
Start:
203,090,654 bp from pter
End:
203,167,405 bp from pter
Size:
76,752 bases
Orientation:
Plus strand

Genomic View for ADORA1 Gene

Genes around ADORA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA1 Gene

Proteins for ADORA1 Gene

  • Protein details for ADORA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30542-AA1R_HUMAN
    Recommended name:
    Adenosine receptor A1
    Protein Accession:
    P30542
    Secondary Accessions:
    • A6NFY5
    • A6NGP4
    • A8K1L3
    • B3KXQ4
    • D2CGD0
    • Q6FHK3
    • Q8TAM8

    Protein attributes for ADORA1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36512 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADORA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADORA1 Gene

Proteomics data for ADORA1 Gene at MOPED

Post-translational modifications for ADORA1 Gene

  • Glycosylation at Asn 159
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA1 Gene

No data available for DME Specific Peptides for ADORA1 Gene

Domains & Families for ADORA1 Gene

Gene Families for ADORA1 Gene

Suggested Antigen Peptide Sequences for ADORA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30542

UniProtKB/Swiss-Prot:

AA1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA1: view

Function for ADORA1 Gene

Molecular function for ADORA1 Gene

GENATLAS Biochemistry:
adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004629 phospholipase C activity IEA --
GO:0031072 heat shock protein binding IEA --
genes like me logo Genes that share ontologies with ADORA1: view
genes like me logo Genes that share phenotypes with ADORA1: view

Animal Models for ADORA1 Gene

MGI Knock Outs for ADORA1:

Animal Model Products

miRNA for ADORA1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA1 Gene

Localization for ADORA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA1 Gene COMPARTMENTS Subcellular localization image for ADORA1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
nucleus 3
extracellular 2
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
GO:0030673 axolemma IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Pathways & Interactions for ADORA1 Gene

genes like me logo Genes that share pathways with ADORA1: view

Gene Ontology (GO) - Biological Process for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001659 temperature homeostasis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002674 negative regulation of acute inflammatory response IEA --
genes like me logo Genes that share ontologies with ADORA1: view

No data available for SIGNOR curated interactions for ADORA1 Gene

Drugs & Compounds for ADORA1 Gene

(131) Drugs for ADORA1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, antagonist, Target 59
Caffeine Approved Nutra Antagonist, antagonist, Target, multitarget 349
Adenosine Approved, Investigational Pharma Agonist, agonist, Target 384
Pentoxifylline Approved, Investigational Pharma antibody, Target, antagonist 92
Aminophylline Approved Pharma Target, antagonist 23

(49) Additional Compounds for ADORA1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 79236
124555-18-6
IBMX
Antagonist
N6-Cyclopentyladenosine
41552-82-3
CPT
Antagonist
SCH4421416
Antagonist

(5) Tocris Compounds for ADORA1 Gene

Compound Action Cas Number
2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist 37739-05-2
2'-MeCCPA Very selective and potent A1 receptor agonist 205171-12-6
GR 79236 A1 agonist 124555-18-6
N6-Cyclopentyladenosine Potent, selective A1 agonist 41552-82-3
SDZ WAG 994 Potent, selective A1 agonist 130714-47-5

(7) ApexBio Compounds for ADORA1 Gene

Compound Action Cas Number
Adenine HCl Adenine receptor agonist 2922-28-3
CGS 21680 HCl A2 adenosine receptor agonist 124431-80-7
Istradefylline (KW-6002) Selective A2A receptor antagonist 155270-99-8
Paeoniflorin Activator of adenosine A1 receptor;glycoside found in peony root 23180-57-6
Preladenant Adenosine A2A receptor antagonist 377727-87-2
Ticlopidine HCl 53885-35-1
Valsartan Angiotensin II AT1 receptor antagonist 137862-53-4
genes like me logo Genes that share compounds with ADORA1: view

Drug Products

Transcripts for ADORA1 Gene

Unigene Clusters for ADORA1 Gene

Adenosine A1 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9: - - - - - - -
SP10: - - -
SP11: -

Relevant External Links for ADORA1 Gene

GeneLoc Exon Structure for
ADORA1
ECgene alternative splicing isoforms for
ADORA1

Expression for ADORA1 Gene

mRNA expression in normal human tissues for ADORA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA1 Gene

This gene is overexpressed in Brain - Cortex (x4.3) and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for ADORA1 Gene

This gene is overexpressed in Frontal cortex (39.3), Retina (18.0), and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADORA1 Gene



SOURCE GeneReport for Unigene cluster for ADORA1 Gene Hs.77867

genes like me logo Genes that share expression patterns with ADORA1: view

Protein tissue co-expression partners for ADORA1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA1 Gene

Orthologs for ADORA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADORA1 35
  • 91.1 (n)
  • 94.48 (a)
ADORA1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADORA1 35
  • 91.62 (n)
  • 94.17 (a)
ADORA1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora1 35
  • 88.65 (n)
  • 94.79 (a)
Adora1 16
Adora1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADORA1 35
  • 99.59 (n)
  • 99.69 (a)
ADORA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adora1 35
  • 88.96 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia ADORA1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADORA1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADORA1 35
  • 78.61 (n)
  • 81.62 (a)
ADORA1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADORA1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adora1 35
  • 67.52 (n)
  • 72.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia adora1-A 35
zebrafish
(Danio rerio)
Actinopterygii adora1 35
  • 68.23 (n)
  • 68.75 (a)
adora1 36
  • 63 (a)
OneToMany
ADORA1 (1 of 2) 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 34 (a)
AdoR 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for ADORA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA1 Gene

ENSEMBL:
Gene Tree for ADORA1 (if available)
TreeFam:
Gene Tree for ADORA1 (if available)

Paralogs for ADORA1 Gene

Paralogs for ADORA1 Gene

(3) SIMAP similar genes for ADORA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADORA1: view

Variants for ADORA1 Gene

Sequence variations from dbSNP and Humsavar for ADORA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035754 A colorectal cancer sample
rs11547175 - 203,128,968(+) GGGAT(G/T)CCACC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11547174 - 203,128,989(+) TCGTG(C/T)CGCTG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11547176 - 203,129,155(+) GGACC(A/G)CTACC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs17852405 - 203,165,701(+) CTGCC(A/C/T)GTCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADORA1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897
nsv873109 CNV Gain 21882294

Variation tolerance for ADORA1 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADORA1 Gene

Human Gene Mutation Database (HGMD)
ADORA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA1 Gene

Disorders for ADORA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADORA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ischemia
brain ischemia
congestive heart failure
  • cardiac failure congestive
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADORA1

Genetic Association Database (GAD)
ADORA1
Human Genome Epidemiology (HuGE) Navigator
ADORA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADORA1
genes like me logo Genes that share disorders with ADORA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADORA1 Gene

Publications for ADORA1 Gene

  1. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PMID: 19019667) Kim S.H. … Park H.S. (Respir Med 2009) 3 48 67
  2. Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. (PMID: 16702031) Gaytan S.P. … PA!saro R. (Auton Neurosci 2006) 23 25 26
  3. Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection. (PMID: 14992338) Nantwi K.D. … Goshgarian H.G. (J Spinal Cord Med 2003) 23 25 26
  4. Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects. (PMID: 8425287) Lerman B.B. (Circulation 1993) 23 25 26
  5. The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. (PMID: 20136829) Buenestado A. … Devillier P. (Br. J. Pharmacol. 2010) 25 26

Products for ADORA1 Gene

Sources for ADORA1 Gene

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