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ADORA1 Gene

protein-coding   GIFtS: 73
GCID: GC01P203059

Adenosine A1 Receptor

  See ADORA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine A1 Receptor1 2
RDC72 5
Adenosine A1 Receptor Variant 12
Adenosine Receptor A12

External Ids:    HGNC: 2621   Entrez Gene: 1342   Ensembl: ENSG000001634857   OMIM: 1027755   UniProtKB: P305423   

Export aliases for ADORA1 gene to outside databases

Previous GC identifers: GC01P200742 GC01P198489 GC01P199526 GC01P200348 GC01P199791 GC01P201326 GC01P174262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADORA1 Gene:
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family.
There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution,
and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl
cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in
kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADORA1 Gene:
ADORA1 (adenosine A1 receptor) is a protein-coding gene. Diseases associated with ADORA1 include brain ischemia, and transient cerebral ischemia. GO annotations related to this gene include protein heterodimerization activity and G-protein beta/gamma-subunit complex binding. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl
cyclase

summary for ADORA1 Gene:
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also
includes A2A, A2B and A3. They display high expression levels in the brain (cortex, cerebellum,
hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also
found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and esophagus.

Gene Wiki entry for ADORA1 (Adenosine A1 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADORA1 gene promoter:
         STAT1   Pax-5   STAT4   STAT1beta   Lmo2   AP-4   STAT1alpha   YY1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ADORA1 promoter sequence
   Search Chromatin IP Primers for ADORA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADORA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ADORA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203059:  view genomic region     (about GC identifiers)

Start:
203,059,782 bp from pter      End:
203,136,533 bp from pter
Size:
76,752 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542 (See protein sequence)
Recommended Name: Adenosine receptor A1  
Size: 326 amino acids; 36512 Da
Secondary accessions: A6NFY5 A6NGP4 A8K1L3 B3KXQ4 Q6FHK3 Q8TAM8
Alternative splicing: 2 isoforms:  P30542-1   P30542-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ADORA1: NX_P30542

Explore proteomics data for ADORA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn159
  • Modification sites at PhosphoSitePlus

  • See ADORA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000665.1  NP_001041695.1  

    ENSEMBL proteins: 
     ENSP00000308549   ENSP00000356205   ENSP00000356204   ENSP00000338435  
    Reactome Protein details: P30542

    ADORA1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADORA: GPCR / Class A : Adenosine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: A1 receptor
    Adenosine receptors

    4 InterPro protein domains:
     IPR001068 Adeno_A1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001634 Adenosn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30542

    ProtoNet protein and cluster: P30542

    2 Blocks protein domains:
    IPB001068 Adenosine A1 receptor signature
    IPB001634 Adenosine receptor signature


    UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with ADORA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AA1R_HUMAN, P30542
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl
    cyclase

         Genatlas biochemistry entry for ADORA1:
    adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in
    bipolar affective disorders inhibiting adenylate cyclase

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0001664G-protein coupled receptor binding IEA--
    GO:0001883purine nucleoside binding IEA--
    GO:0004629phospholipase C activity IEA--
    GO:0004930G-protein coupled receptor activity ----
         
    Find genes that share ontologies with ADORA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADORA1:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adora1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  nervous system 
     normal  renal/urinary system  respiratory system 

    Find genes that share phenotypes with ADORA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adora1tm1Bbf for ADORA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADORA1
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    2 qRT-PCR Assays for microRNAs that regulate ADORA1:
    hsa-miR-145* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidADORA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AA1R_HUMAN, P30542: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1530647
    GO:0012505endomembrane system ----
    GO:0014069postsynaptic density IEA--

    Find genes that share ontologies with ADORA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADORA1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    Adenosine P1 receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Development A3 receptor signaling
    Development A1 receptor signaling0.65
    5Circadian entrainment
    Morphine addiction0.53


    Find genes that share SuperPaths with ADORA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ADORA1
        Beta-Adrenergic Signaling

    1 GeneGo (Thomson Reuters) Pathway for ADORA1
        Development A1 receptor signaling

    2 BioSystems Pathways for ADORA1
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs


    2 Reactome Pathways for ADORA1
        G alpha (i) signalling events
    Adenosine P1 receptors


    2 Kegg Pathways  (Kegg details for ADORA1):
        Neuroactive ligand-receptor interaction
    Morphine addiction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA1 (see all 6): 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              GABA & Glutamate in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADORA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADORA1 (P305421, 2, 3 ENSP000003085494) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292741, 3, ENSP000003366304EBI-2903663,EBI-2902702 I2D: score=4 STRING: ENSP00000336630
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ADAP008133, ENSP000003619654I2D: score=2 STRING: ENSP00000361965
    EPB41L2O434913, ENSP000003384814I2D: score=1 STRING: ENSP00000338481
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001659temperature homeostasis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0002674negative regulation of acute inflammatory response IEA--

    Find genes that share ontologies with ADORA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADORA1
      Browse compounds at ApexBio 

    Compounds for ADORA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist [37739-05-2]
    N6-Cyclopentyladenosine Potent, selective A1 agonist [41552-82-3]
    2'-MeCCPAVery selective and potent A1 receptor agonist[205171-12-6]
    SLV 320Potent and selective A1 antagonist[251945-92-3]
    DPCPXA1 selective antagonist[102146-07-6]

    5 HMDB Compounds for ADORA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    CaffeineHycomine (see all 15)58-08-2--
    Gabapentin1-(Aminomethyl)cyclohexaneacetic acid (see all 9)60142-96-3--
    ImipramineAntideprin (see all 27)50-49-7--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--

    10 DrugBank Compounds for ADORA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Theobromine-- 83-67-0targetantagonist17372967 3588607 16702031 12602592 17085856 17162470 15095008 17126319
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 20370661 20370662 17438146 17442976 20136829
    CaffeineCafeina (see all 7)58-08-2targetantagonist multitarget17372967 16702031 11752352 17085856 17162470 17126319
    GabapentinGabapentin GR (see all 6)60142-96-3targetagonist15140630 15572277 15765150
    AminophyllineAminophyllin (see all 4)317-34-0targetantagonist12735630 8425287
    OxtriphyllineCholine theophyllinate (see all 2)4499-40-5targetantagonist3588607 14992338
    TheophyllineDimethylxanthine (see all 6)58-55-9targetantagonist3588607 14992338
    Defibrotide-- 83712-60-1target--8405101
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetantagonist2997628
    Pentoxifylline-- 6493-05-6targetantagonist3588607

    Selected IUPHAR Ligands for ADORA1 (A1 receptor) (see all 65)    About this table
    LigandTypeActionAffinityPubmed IDs
    cyclopentyladenosine
    AgonistFull agonist6.5 - 9.416444290 15740718 7798201 9827575 9920910 15476669 16518376
    [3H]CCPA
    AgonistFull agonist9.29459566 9920910
    [3H]DPCPX
    AntagonistAntagonist8.4 - 9.29459566 9933143 9827575 8300561 11705449 9920910
    rolofylline
    AntagonistAntagonist8.1 - 9.1417125264 9191953
    LUF5981
    AntagonistAntagonist9.0517300165
    SLV320
    AntagonistAntagonist917558436
    CPFPX
    AntagonistAntagonist8.912408725
    FR194921
    AntagonistAntagonist8.915351792
    DPCPX
    AntagonistAntagonist8.5 - 8.715740718 16902942 9920910 8032613
    (R)-PIA
    AgonistFull agonist6.4 - 8.79459566 7798201 9920910 15476669 8300561

    Selected Novoseek inferred chemical compound relationships for ADORA1 gene (see all 89)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpcpx 93.4 83 15572277 (2), 1331765 (2), 16329119 (2), 2143656 (1) (see all 52)
    n6-cyclopentyladenosine 93.3 44 12819231 (2), 10676861 (2), 9692782 (2), 15145705 (2) (see all 23)
    tecadenoson 89.4 2 16230891 (1), 15956124 (1)
    8-cyclopentyltheophylline 88.6 22 15145705 (2), 9185835 (1), 7649219 (1), 15992577 (1) (see all 11)
    n(6)-cyclohexyladenosine 87.9 23 11230994 (2), 8605954 (1), 9769229 (1), 7980632 (1) (see all 12)
    pd81723 87 5 8700102 (2), 11163328 (1), 14645687 (1)
    (r)-(phenylisopropyl)adenosine 84.3 10 8533136 (1), 2304450 (1), 9080460 (1), 1646818 (1) (see all 6)
    bamiphylline 83.3 7 8781823 (2), 8339412 (1), 8336989 (1), 7798511 (1) (see all 5)
    5'-n-ethylcarboxamidoadenosine 82.4 7 8605954 (1), 17249651 (1), 10029519 (1), 9692782 (1) (see all 6)
    n(6)-cyclohexyl-2-o-methyladenosine 80.6 2 8822971 (2)

    1 PharmGKB related drug/compound annotation for ADORA1 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    Find genes that share compounds with ADORA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADORA1 gene (2 alternative transcripts): 
    NM_000674.2  NM_001048230.1  

    Unigene Cluster for ADORA1:

    Adenosine A1 receptor
    Hs.77867  [show with all ESTs]
    Unigene Representative Sequence: AK127752
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309502 ENST00000367236(uc001gzf.1) ENST00000367235(uc010pqg.1)
    ENST00000464019 ENST00000472535 ENST00000467253 ENST00000337894(uc001gze.1 uc009xak.1 uc010pqh.1)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ADORA1:
    hsa-miR-145* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidADORA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ADORA1
      QuantiFast Probe-based Assays in human, mouse, rat ADORA1

    Additional mRNA sequence: 

    AB004662.1 AK095060.1 AK127752.1 AK289928.1 AK293647.1 AK295584.1 AK308733.1 AK316106.1 
    AY136746.1 BC026340.1 BT019854.1 CR541749.1 EF057066.1 S45235.1 S56143.1 X68485.1 

    14 DOTS entries:

    DT.92423938  DT.100786201  DT.97813786  DT.442942  DT.101983052  DT.100023710  DT.121394043  DT.121394049 
    DT.86851151  DT.100668605  DT.100696781  DT.121394028  DT.121394033  DT.100786204 

    Selected AceView cDNA sequences (see all 92):

    BU740906 BU173243 BE250294 BQ958975 BQ231015 CR612499 AU131780 BF724405 
    BM548386 BI772068 CB126404 AK095060 BU193080 BM673005 CD014133 BI829806 
    BM055365 BE314976 AY136746 BX350062 CF147808 BM043285 AA350871 CD609329 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                                  -     -     -     -     -     -     -                                 
    SP2:                                                  -     -     -                 -     -                                 
    SP3:                    -     -     -                 -     -     -     -     -     -     -                                 
    SP4:                                                  -     -     -     -     -     -                                       
    SP5:                                      -           -     -     -                                                         


    ECgene alternative splicing isoforms for ADORA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADORA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTAATAA
    ADORA1 Expression
    About this image


    ADORA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
    ADORA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADORA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77867
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADORA1 (see all 6): 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              GABA & Glutamate in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADORA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adora11 , 5 adenosine A1 receptor1, 5 88.65(n)1
    94.79(a)1
      1 (58.15 cM)5
    115391  NM_001282945.11  NP_001269874.11 
     1341992235 
    chicken
    (Gallus gallus)
    Aves ADORA11 adenosine A1 receptor 78.61(n)
    81.62(a)
      374212  NM_204316.3  NP_989647.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADORA16
    adenosine A1 receptor
    77(a)
    1 ↔ 1
    4(133197917-133262336)
    African clawed frog
    (Xenopus laevis)
    Amphibia adora1-A2 adenosine A1 receptor 73.65(n)    AJ249842.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adora11 adenosine A1 receptor 68.23(n)
    68.75(a)
      100150997  NM_001128584.1  NP_001122056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97533 G-protein coupled receptor protein
    signaling pathway more
    34(a)   99D8   --
    worm
    (Caenorhabditis elegans)
    Secernentea ador-16
    Protein ADOR-1, isoform b (ador-1) mRNA, complete ...
    22(a)
    1 → many
    II(12497210-12502878) WBGene00011878


    ENSEMBL Gene Tree for ADORA1 (if available)
    TreeFam Gene Tree for ADORA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADORA1 gene
    GPR1192  ADORA2B2  ADORA2A2  
    3 SIMAP similar genes for ADORA1 using alignment to 2 protein entries:     AA1R_HUMAN (see all proteins):
    ADORA3    ADORA2A    ADORA2B

    Find genes that share paralogs with ADORA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADORA1 (see all 1003)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357544
    A colorectal cancer sample4--see VAR_0357542 E K mis40--------
    rs776733641,2
    C,F--203094870(+) CTCTCG/TGTCAA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs741369451,2
    C,F--203094927(+) AGCACC/TGACCC 2 -- us2k13Minor allele frequency- T:0.11WA CSA 122
    rs1133001661,2
    F--203094981(+) TTCCCC/TCAAGG 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1438814281,2
    --203095107(+) TTTGGC/TTTATT 2 -- us2k10--------
    rs1486839981,2
    C--203095153(+) TTATGC/GAAATG 2 -- us2k10--------
    rs1893054281,2
    C--203095196(+) TGAATC/TGGAGG 2 -- us2k10--------
    rs1422103181,2
    --203095239(+) GTGCTC/TAGTTG 2 -- us2k10--------
    rs356103831,2
    F--203095269(+) CTGTCA/CATAGT 2 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1820037161,2
    --203095320(+) TGGGCC/TCATCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADORA1 (203059782 - 203136533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADORA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832370CNV Loss17160897
    nsv873109CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADORA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADORA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102775    OMIM disorders: --

    4 diseases for ADORA1:    
    About MalaCards
    brain ischemia    transient cerebral ischemia    retinal ischemia    ischemia

    1 disease from the University of Copenhagen DISEASES database for ADORA1:
    Vascular disease

    Find genes that share disorders with ADORA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADORA1 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 46.7 21 7884404 (1), 10396621 (1), 11744026 (1), 18535281 (1) (see all 16)
    brain ischemia 40.5 4 9988118 (1), 10355598 (1), 11320597 (1), 8790990 (1)
    cerebral ischemia 36.5 7 8050467 (2), 11320597 (1), 17650627 (1), 8790990 (1) (see all 6)
    carotid occlusion 24.5 1 2364291 (1)
    heart failure congestive 17.8 5 10636259 (1), 11558828 (1), 19804290 (1), 17923351 (1) (see all 5)
    heart failure 17.1 10 17936154 (2), 8822971 (1), 19919976 (1), 20027105 (1) (see all 9)
    transient cerebral ischemia 16.8 3 1666408 (2), 1529167 (1)
    bradycardia 16.6 3 9763631 (1), 9203590 (1), 8276062 (1)
    effects cardiovascular 15.8 2 9988118 (1), 10355598 (1)
    myocardial ischemia 14.2 1 9191496 (1)

    Genetic Association Database (GAD): ADORA1
    Human Genome Epidemiology (HuGE) Navigator: ADORA1 (17 documents)

    Export disorders for ADORA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADORA1 gene, integrated from 10 sources (see all 492):
    (articles sorted by number of sources associating them with ADORA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. (PubMed id 19019667)1, 4, 9 Kim S.H....Park H.S. (Respir Med 2009)
    2. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)1, 4, 9 Wright K....Griffiths L.R. (J. Hypertens. 2004)
    3. Cloning and functional characterization of a human A1 adenosine receptor. (PubMed id 1530647)1, 2, 9 Libert F.... Mendla K.D. (Biochem. Biophys. Res. Commun. 1992)
    4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    5. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PubMed id 20392501)1, 4 Gass N....Paunio T. (J Affect Disord 2010)
    6. Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI. (PubMed id 20609566)1, 4 Wagner A.K....Conley Y.P. (Epilepsy Res. 2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population. (PubMed id 19820430)1, 4 Gotoh L....Kanba S. (Psychiatr. Genet. 2009)
    10. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134 HGNC: 262 AceView: ADORA1 Ensembl:ENSG00000163485 euGenes: HUgn134
    ECgene: ADORA1 Kegg: 134 H-InvDB: ADORA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADORA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADORA1 gene:
    Search GeneIP for patents involving ADORA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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