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Aliases for ADORA1 Gene

Aliases for ADORA1 Gene

  • Adenosine A1 Receptor 2 3
  • RDC7 3 6
  • Adenosine A1 Receptor Variant 1 3
  • Adenosine Receptor A1 3

External Ids for ADORA1 Gene

Summaries for ADORA1 Gene

Entrez Gene Summary for ADORA1 Gene

  • The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA1 Gene

ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include brain ischemia and ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and G-protein beta/gamma-subunit complex binding. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA1 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

Tocris Summary for ADORA1 Gene

  • The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. They display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and esophagus.

Gene Wiki entry for ADORA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA1 Gene

Genomics for ADORA1 Gene

Genomic Location for ADORA1 Gene

Start:
203,090,654 bp from pter
End:
203,167,405 bp from pter
Size:
76,752 bases
Orientation:
Plus strand

Genomic View for ADORA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA1 Gene

Regulatory Elements for ADORA1 Gene

Proteins for ADORA1 Gene

  • Protein details for ADORA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30542-AA1R_HUMAN
    Recommended name:
    Adenosine receptor A1
    Protein Accession:
    P30542
    Secondary Accessions:
    • A6NFY5
    • A6NGP4
    • A8K1L3
    • B3KXQ4
    • D2CGD0
    • Q6FHK3
    • Q8TAM8

    Protein attributes for ADORA1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36512 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADORA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADORA1 Gene

Proteomics data for ADORA1 Gene at MOPED

Post-translational modifications for ADORA1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn159

Other Protein References for ADORA1 Gene

No data available for DME Specific Peptides for ADORA1 Gene

Domains for ADORA1 Gene

Gene Families for ADORA1 Gene

HGNC:
  • ADORA :GPCR / Class A : Adenosine receptors
IUPHAR :

UniProtKB/Swiss-Prot:

AA1R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P30542
genes like me logo Genes that share domains with ADORA1: view

Function for ADORA1 Gene

Molecular function for ADORA1 Gene

GENATLAS Biochemistry: adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

Gene Ontology (GO) - Molecular Function for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IEA --
GO:0001883 purine nucleoside binding IEA --
GO:0004629 phospholipase C activity IEA --
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with ADORA1: view
genes like me logo Genes that share phenotypes with ADORA1: view

Animal Models for ADORA1 Gene

MGI Knock Outs for ADORA1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADORA1 Gene

Localization for ADORA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA1 Gene COMPARTMENTS Subcellular localization image for ADORA1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1530647
GO:0012505 endomembrane system --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Pathways for ADORA1 Gene

genes like me logo Genes that share pathways with ADORA1: view

Pathways by source for ADORA1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ADORA1 Gene
1 Qiagen pathway for ADORA1 Gene
2 BioSystems pathways for ADORA1 Gene

Gene Ontology (GO) - Biological Process for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001659 temperature homeostasis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Compounds for ADORA1 Gene

(5) Tocris Compounds for ADORA1 Gene

Compound Action Cas Number
2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist [37739-05-2]
2-MeCCPA Very selective and potent A1 receptor agonist [205171-12-6]
DPCPX A1 selective antagonist [102146-07-6]
N6-Cyclopentyladenosine Potent, selective A1 agonist [41552-82-3]
SLV 320 Potent and selective A1 antagonist [251945-92-3]

(5) HMDB Compounds for ADORA1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
58-61-7
Caffeine
  • Hycomine
58-08-2
Gabapentin
  • 1-(Aminomethyl)cyclohexaneacetic acid
60142-96-3
Imipramine
  • Antideprin
50-49-7
Theophylline
  • 1,3-Dimethylxanthine
58-55-9

(10) Drugbank Compounds for ADORA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine
  • 2'-Deoxyadenosine
58-61-7 target agonist
Aminophylline
  • Aminophyllin
317-34-0 target antagonist
Caffeine
  • Cafeina
58-08-2 target antagonist multitarget
Defibrotide
83712-60-1 target
Dyphylline
  • Dihydroxypropyl Theophylline
479-18-5 target antagonist

(65) IUPHAR Ligand for ADORA1 Gene

Ligand Type Action Affinity Pubmed IDs
SCH4421416 Antagonist Antagonist 10.3
CGS 15943 Antagonist Antagonist 9.4
apadenoson Agonist Agonist 9.3
[3H]CCPA Agonist Full agonist 9.2
[3H]DPCPX Antagonist Antagonist 9.2
SCH 58261 Antagonist Antagonist 9.2
ZM-241385 Antagonist Antagonist 9.1
preladenant Antagonist Antagonist 9.05
XAC Antagonist Antagonist 9
FR194921 Antagonist Antagonist 8.9
BIIB014 Antagonist Antagonist 8.89
NECA Agonist Full agonist 8.7
(R,S)-PHPNECA Agonist Full agonist 8.5
2-hexynyl-NECA Agonist Full agonist 8.3
MSX-2 Antagonist Antagonist 8.27
ST-1535 Antagonist Antagonist 8.18
CGS 21680 Agonist Full agonist 8.1
CPT Antagonist Antagonist 8
istradefylline Antagonist Antagonist 7.92
LUF5831 Agonist Partial agonist 7.7
DPCPX Antagonist Antagonist 7.2
rolofylline Antagonist Antagonist 6.97
MRE 3008F20 Antagonist Antagonist 6.8
2-chloroadenosine Agonist Full agonist 6.8
LUF5981 Antagonist Antagonist 6.71
TCPA Agonist Agonist 6.68
AS70 Antagonist Antagonist 6.6
binodenoson Agonist Agonist 6.57
regadenoson Agonist Agonist 6.54
AS100 Antagonist Antagonist 6.5
SLV320 Antagonist Antagonist 6.4
KF26777 Antagonist Antagonist 6.33
IB-MECA Agonist Full agonist 6.3
MRS1754 Antagonist Antagonist 6.3
(R)-PIA Agonist Full agonist 6.2
PENECA Agonist Full agonist 6.2
L-97-1 Antagonist Antagonist 6.2
ATL802 Antagonist Antagonist 6.18
cyclopentyladenosine Agonist Full agonist 6.1
AS99 Antagonist Antagonist 6.1
CPFPX Antagonist Antagonist 6.03
MRE 2029F20 Antagonist Antagonist 6
LAS38096 Antagonist Antagonist 6
HEMADO Agonist Agonist 5.92
FK-453 Antagonist Antagonist 5.89
PSB-11 Antagonist Antagonist 5.89
theophylline Antagonist Antagonist 5.8
MRS3558 Agonist Agonist 5.63
CCPA Agonist Full agonist 5.6
PSB-10 Antagonist Antagonist 5.57
CVT-6883 Antagonist Antagonist 5.48
MRS1523 Antagonist Antagonist 5.44
Cl-IB-MECA Agonist Agonist 5.27
tonapofylline Antagonist Antagonist 5.19
CP608,039 Agonist Agonist 5.14
(S)-PIA Agonist Full agonist 5.1
IBMX Antagonist Antagonist 5.1
GS9667 Agonist Agonist 5
MRS1191 Antagonist Antagonist 5
PSB603 Antagonist Antagonist 5
PSB1115 Antagonist Antagonist 5
Bay60-6583 Agonist Agonist 5
MRS5151 Agonist Agonist 5
adenosine Channel blocker None 3.2
caffeine Activator None

(89) Novoseek inferred chemical compound relationships for ADORA1 Gene

Compound -log(P) Hits PubMed IDs
dpcpx 93.4 55
n6-cyclopentyladenosine 93.3 27
tecadenoson 89.4 2
8-cyclopentyltheophylline 88.6 12
n(6)-cyclohexyladenosine 87.9 13

(1) PharmGKB related drug/compound annotations for ADORA1 Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with ADORA1: view

Transcripts for ADORA1 Gene

Unigene Clusters for ADORA1 Gene

Adenosine A1 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9: - - - - - - -
SP10: - - -
SP11: -

Relevant External Links for ADORA1 Gene

GeneLoc Exon Structure for
ADORA1
ECgene alternative splicing isoforms for
ADORA1

Expression for ADORA1 Gene

mRNA expression in normal human tissues for ADORA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA1 Gene

This gene is overexpressed in Brain - Cortex (4.3) and Brain - Spinal cord (cervical c-1) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADORA1 Gene

SOURCE GeneReport for Unigene cluster for ADORA1 Gene Hs.77867

genes like me logo Genes that share expressions with ADORA1: view

Orthologs for ADORA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADORA1 36
  • 99.59 (n)
  • 99.69 (a)
ADORA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADORA1 36
  • 91.1 (n)
  • 94.48 (a)
ADORA1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADORA1 36
  • 91.62 (n)
  • 94.17 (a)
ADORA1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora1 36
  • 88.65 (n)
  • 94.79 (a)
Adora1 16
Adora1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADORA1 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADORA1 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adora1 36
  • 88.96 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves ADORA1 36
  • 78.61 (n)
  • 81.62 (a)
ADORA1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADORA1 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia adora1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia adora1 36
  • 67.52 (n)
  • 72.35 (a)
zebrafish
(Danio rerio)
Actinopterygii adora1 36
  • 68.23 (n)
  • 68.75 (a)
adora1 37
  • 63 (a)
OneToMany
ADORA1 (1 of 2) 37
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AdoR 37
  • 14 (a)
OneToMany
CG9753 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea ador-1 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for ADORA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA1 Gene

ENSEMBL:
Gene Tree for ADORA1 (if available)
TreeFam:
Gene Tree for ADORA1 (if available)

Paralogs for ADORA1 Gene

Paralogs for ADORA1 Gene

Selected SIMAP similar genes for ADORA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADORA1: view

Variants for ADORA1 Gene

Sequence variations from dbSNP and Humsavar for ADORA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs903364 -- 203,164,740(-) ACCCA(A/G)GTGAT intron-variant
rs1050284 -- 203,128,988(+) ATCGT(C/G)TCGCT synonymous-codon, reference, utr-variant-5-prime, upstream-variant-2KB
rs1106162 -- 203,164,734(-) GTGAT(C/T)AACAA intron-variant
rs1417151 -- 203,149,504(+) GACAG(A/G)CTGTT intron-variant
rs1417152 -- 203,156,264(+) GAGAG(A/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADORA1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897
nsv873109 CNV Gain 21882294

Relevant External Links for ADORA1 Gene

HapMap Linkage Disequilibrium report
ADORA1
Human Gene Mutation Database (HGMD)
ADORA1

Disorders for ADORA1 Gene

(1) University of Copenhagen DISEASES for ADORA1 Gene

(42) Novoseek inferred disease relationships for ADORA1 Gene

Disease -log(P) Hits PubMed IDs
ischemia 46.7 16
brain ischemia 40.5 4
cerebral ischemia 36.5 7
carotid occlusion 24.5 1
heart failure congestive 17.8 5

Relevant External Links for ADORA1

Genetic Association Database (GAD)
ADORA1
Human Genome Epidemiology (HuGE) Navigator
ADORA1
genes like me logo Genes that share disorders with ADORA1: view

No data available for UniProtKB/Swiss-Prot for ADORA1 Gene

Publications for ADORA1 Gene

  1. Cloning and functional characterization of a human A1 adenosine receptor. (PMID: 1530647) Libert F. … Mendla K.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  2. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. (PMID: 8450977) UA8as J. … Cotman C.W. (Neuroscience 1993) 3 23
  3. Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling. (PMID: 9166747) Ho M.K. … Wong Y.H. (J. Neurochem. 1997) 3 23
  4. Stimulation by n6-cyclopentyladenosine of A1 adenosine receptors, coupled to galphai2 protein subunit, has a capacitative effect on human spermatozoa. (PMID: 11369591) Allegrucci C. … Minelli A. (Biol. Reprod. 2001) 3 23
  5. Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. (PMID: 16709961) Ethier M.F. … Madison J.M. (Am. J. Respir. Cell Mol. Biol. 2006) 3 23

Products for ADORA1 Gene

  • antibodies-online peptides for ADORA1
  • antibodies-online antibodies for ADORA1
  • antibodies-online kits for ADORA1

Sources for ADORA1 Gene

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