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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADORA1 Gene

protein-coding   GIFtS: 72
GCID: GC01P203059

adenosine A1 receptor
 Explore 59 diseases affiliated with
ADORA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADORA1    

Aliases
for ADORA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenosine A1 Receptor1 2
RDC71 2 5
Adenosine Receptor A12

External Ids:    HGNC: 2621   Entrez Gene: 1342   Ensembl: ENSG000001634857   OMIM: 1027755   UniProtKB: P305423   

Export aliases for ADORA1 gene to outside databases

Previous GC identifers: GC01P200742 GC01P198489 GC01P199526 GC01P200348 GC01P199791 GC01P201326 GC01P174262


Summaries
for ADORA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADORA1:
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family.
There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and
together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and
play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and
ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl
cyclase

summary for ADORA1:
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also
includes A2A, A2B and A3. They display high expression levels in the brain (cortex, cerebellum,
hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also
found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and esophagus.

Gene Wiki entry for ADORA1 (Adenosine A1 receptor)


Genomic Views
for ADORA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADORA1 gene promoter:
         STAT1   Pax-5   STAT4   STAT1beta   Lmo2   AP-4   STAT1alpha   YY1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ADORA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADORA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADORA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ADORA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADORA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203059:  view genomic region     (about GC identifiers)

Start:
 203,059,782 bp from pter      End:
 203,136,533 bp from pter
Size:
 76,752 bases      Orientation:
 plus strand

Proteins
for ADORA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542 (See protein sequence)
Recommended Name: Adenosine receptor A1  
Size: 326 amino acids; 36512 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A6NFY5 A6NGP4 A8K1L3 B3KXQ4 Q6FHK3 Q8TAM8
Alternative splicing: 2 isoforms:  P30542-1   P30542-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ADORA1: NX_P30542

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30542

    • ADORA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000665.1  NP_001041695.1  

    ENSEMBL proteins: 
     ENSP00000308549   ENSP00000356205   ENSP00000356204   ENSP00000338435  
    Reactome Protein details: P30542
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ADORA1 Protein
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    OriGene Protein Over-expression Lysate: ADORA1
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    Uscn Proteins for ADORA1

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1530647
    GO:0012505endomembrane system IEA--
    GO:0014069postsynaptic density IEA--


    ADORA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADORA1

    Protein Domains /
    Families
    for ADORA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADORA1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001634 Adenosn_rcpt
     IPR001068 Adeno_A1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30542

    ProtoNet protein and cluster: P30542

    2 Blocks protein families:
    IPB001068 Adenosine A1 receptor signature
    IPB001634 Adenosine receptor signature


    UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for ADORA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AA1R_HUMAN, P30542
    Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl
    cyclase

         Genatlas biochemistry entry for ADORA1:
    adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in bipolar
    affective disorders inhibiting adenylate cyclase

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADORA1
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    hsa-miR-145* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: ADORA1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ADORA1 (NM_000674)
    Sino Biological Human cDNA Clone for ADORA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADORA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADORA1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0001664G-protein coupled receptor binding IEA--
    GO:0001883purine nucleoside binding IEA--
    GO:0004629phospholipase C activity IEA--
    GO:0005515protein binding IPI16481441


    ADORA1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ADORA1:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Adora1tm1Bbf for ADORA1
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adora1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  nervous system 
     normal  renal/urinary system  respiratory system 

    ADORA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADORA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		GPCRs, Class A Rhodopsin-like0.41
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    		G alpha (i) signalling events0.44
    2Nucleotide-like (purinergic) receptors
    		Nucleotide-like (purinergic) receptors1.00
    		Adenosine P1 receptors0.25
    		Nucleotide GPCRs0.56
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Development_A3 receptor signaling
    		Development_A1 receptor signaling0.65
    		Development A1 receptor signaling0.65
    5Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    		Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.45

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ADORA1
        Development A1 receptor signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ADORA1
        Beta-Adrenergic Signaling

    1 GeneGo (Thomson Reuters) Pathway for ADORA1
        Development A1 receptor signaling

    2 BioSystems Pathways for ADORA1 
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    5/8        Reactome Pathways for ADORA1 (see all 8)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events
    Adenosine P1 receptors

    1 PharmGKB Pathway for ADORA1
        Methotrexate Pathway (Cancer Cell), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for ADORA1):
        Neuroactive ligand-receptor interaction


    ADORA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADORA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for ADORA1 (P305421, 2, 3 ENSP000003085494) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292741, 3, ENSP000003366304EBI-2903663,EBI-2902702 I2D: score=4 STRING: ENSP00000336630
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ADAP008133, ENSP000003619654I2D: score=2 STRING: ENSP00000361965
    DRD1P217283, ENSP000003276524I2D: score=2 STRING: ENSP00000327652
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0001659temperature homeostasis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001973adenosine receptor signaling pathway ----
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--


    ADORA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADORA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADORA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ADORA1

    Compounds for ADORA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (±)-5'-Chloro-5'-deoxy-ENBAHighly selective A1 agonist[103626-26-2]
    2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist [37739-05-2]
    DPCPXA1 selective antagonist[102146-07-6]
    SLV 320Potent and selective A1 antagonist[251945-92-3]
    PSB 36Potent and selective A1 antagonist[524944-72-7]

    5 HMDB Compounds for ADORA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    CaffeineHycomine (see all 15)58-08-2--
    Gabapentin1-(Aminomethyl)cyclohexaneacetic acid (see all 9)60142-96-3--
    ImipramineAntideprin (see all 27)50-49-7--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--

    10 DrugBank Compounds for ADORA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Theobromine-- 83-67-0targetantagonist17372967 3588607 16702031 12602592 17085856 17162470 15095008 17126319
    Adenosine2'-Deoxyadenosine (see all 11)58-61-7targetagonist17321471 20370661 20370662 17438146 17442976 20136829
    CaffeineCafeina (see all 7)58-08-2targetantagonist multitarget17372967 16702031 11752352 17085856 17162470 17126319
    GabapentinGabapentin GR (see all 6)60142-96-3targetagonist15140630 15572277 15765150
    AminophyllineAminophyllin (see all 4)317-34-0targetantagonist12735630 8425287
    Oxtriphylline-- 4499-40-5targetantagonist3588607 14992338
    TheophyllineDimethylxanthine (see all 6)58-55-9targetantagonist3588607 14992338
    Defibrotide-- 83712-60-1target--8405101
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetantagonist2997628
    Pentoxifylline-- 6493-05-6targetantagonist3588607

    10/89 Novoseek chemical compound relationships for ADORA1 gene (see all 89)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpcpx 93.4 83 15572277 (2), 1331765 (2), 16329119 (2), 2143656 (1) (see all 52)
    n6-cyclopentyladenosine 93.3 44 12819231 (2), 10676861 (2), 9692782 (2), 15145705 (2) (see all 23)
    tecadenoson 89.4 2 16230891 (1), 15956124 (1)
    8-cyclopentyltheophylline 88.6 22 15145705 (2), 9185835 (1), 7649219 (1), 15992577 (1) (see all 11)
    n(6)-cyclohexyladenosine 87.9 23 11230994 (2), 8605954 (1), 9769229 (1), 7980632 (1) (see all 12)
    pd81723 87 5 8700102 (2), 11163328 (1), 14645687 (1)
    (r)-(phenylisopropyl)adenosine 84.3 10 8533136 (1), 2304450 (1), 9080460 (1), 1646818 (1) (see all 6)
    bamiphylline 83.3 7 8781823 (2), 8339412 (1), 8336989 (1), 7798511 (1) (see all 5)
    5'-n-ethylcarboxamidoadenosine 82.4 7 8605954 (1), 17249651 (1), 10029519 (1), 9692782 (1) (see all 6)
    n(6)-cyclohexyl-2-o-methyladenosine 80.6 2 8822971 (2)

    Search CenterWatch for drugs/clinical trials and news about ADORA1 / AA1R 

    Transcripts
    for ADORA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADORA1 gene (2 alternative transcripts): 
    NM_000674.2  NM_001048230.1  

    Unigene Cluster for ADORA1:

    Adenosine A1 receptor
    Hs.77867  [show with all ESTs]
    Unigene Representative Sequence: AK127752
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309502 ENST00000367236(uc001gzf.1) ENST00000367235(uc010pqg.1)
    ENST00000464019 ENST00000472535 ENST00000467253 ENST00000337894(uc001gze.1 uc009xak.1 uc010pqh.1)


    miRNA
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    hsa-miR-145* hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmid: ADORA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB004662.1 AK095060.1 AK127752.1 AK289928.1 AK293647.1 AK295584.1 AK308733.1 AK316106.1 
    AY136746.1 BC026340.1 BT019854.1 CR541749.1 EF057066.1 S45235.1 S56143.1 X68485.1 

    14 DOTS entries:

    DT.92423938  DT.100786201  DT.97813786  DT.442942  DT.101983052  DT.100023710  DT.121394043  DT.121394049 
    DT.86851151  DT.100668605  DT.100696781  DT.121394028  DT.121394033  DT.100786204 

    24/92 AceView cDNA sequences (see all 92):

    BQ958975 BE250294 BM548386 BM673005 AK095060 BF724405 BU173243 BM055365 
    CR612499 BI829806 BU740906 AU131780 BU193080 CD014133 CB126404 BI772068 
    BQ231015 BX327140 CD609327 AA350871 BI599197 AU147420 BG168804 AB004662 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                                  -     -     -     -     -     -     -                                 
    SP2:                                                  -     -     -                 -     -                                 
    SP3:                    -     -     -                 -     -     -     -     -     -     -                                 
    SP4:                                                  -     -     -     -     -     -                                       
    SP5:                                      -           -     -     -                                                         


    ECgene alternative splicing isoforms for ADORA1

    Expression
    for ADORA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADORA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGACTAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADORA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Nkx2-1 GFP+ cells (Efficient derivation...)
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See ADORA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADORA1

    SOURCE GeneReport for Unigene cluster: Hs.77867
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADORA1 (see all 6): 
              Neurogenesis in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              GABA & Glutamate in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADORA1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADORA1

    Orthologs
    for ADORA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADORA1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADORA11 adenosine A1 receptor 80.65(n)
    84.19(a)    		   374212  NM_204316.3  NP_989647.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADORA16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 4(133197917-133259501)
    African clawed frog
    (Xenopus laevis)    		 Amphibia adora1-A2 adenosine A1 receptor 73.65(n)    AJ249842.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001509971 similar to adenosine A1 receptor 68.23(n)
    68.75(a)    		   100150997  NM_001128584.1  NP_001122056.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG97533 G-protein coupled receptor protein signaling
    pathway more    		 34(a)   99D8   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T21B4.46
    		 Protein T21B4.4, isoform b
    		 22(a)
    		 1 → many
    		 II(12497146-12502814)


    ENSEMBL Gene Tree for ADORA1 (if available)
    TreeFam Gene Tree for ADORA1 (if available) 

    Paralogs
    for ADORA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADORA1 gene
    GPR1192  ADORA2B2  ADORA32  ADORA2A2  
    3 SIMAP similar genes for ADORA1 using alignment to 1 protein entry:     AA1R_HUMAN:
    ADORA3    ADORA2A    ADORA2B

    ADORA1 for paralogs           About GeneDecksing



    Genomic Variants
    for ADORA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/895 NCBI SNPs in ADORA1 are shown (see all 895)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs776733641,2
    		F,--203094870(+) CTCTCG/TGTCAA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs741369451,2
    		C,--203094927(+) AGCACC/TGACCC 2 -- us2k13Minor allele frequency- T:0.11WA CSA 122
    rs1133001661,2
    		F--203094981(+) TTCCCC/TCAAGG 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1438814281,2
    		--203095107(+) TTTGGC/TTTATT 2 -- us2k10--------
    rs1486839981,2
    		--203095153(+) TTATGC/GAAATG 2 -- us2k10--------
    rs1893054281,2
    		--203095196(+) TGAATC/TGGAGG 2 -- us2k10--------
    rs1422103181,2
    		--203095239(+) GTGCTC/TAGTTG 2 -- us2k10--------
    rs356103831,2
    		F,--203095269(+) CTGTCA/CATAGT 2 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1820037161,2
    		--203095320(+) TGGGCC/TCATCT 2 -- us2k10--------
    rs1467678791,2
    		--203095336(+) TTCACA/TGTCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADORA1 (203059782 - 203136533 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADORA1: --
    Human Gene Mutation Database (HGMD): ADORA1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADORA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADORA1

    Disorders / Diseases
    for ADORA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADORA1 for disorders           About GeneDecksing

    OMIM gene information: 102775    OMIM disorders: --

    20/59 diseases for ADORA1 (see all 59):    About MalaCards
    transient cerebral ischemia    temporal lobe epilepsy    atrial fibrillation    traumatic brain injury
    morphine dependence    status epilepticus    bipolar affective disorder    congestive heart failure
    brain injury    mood disorder    insulin resistance    ischemia
    brain ischemia    anorexia nervosa    cystic fibrosis    panic disorder
    rheumatoid arthritis    multiple sclerosis    glaucoma    pick's disease

    1 disease from the University of Copenhagen DISEASES database for ADORA1:
    Vascular disease

    10/42 Novoseek disease relationships for ADORA1 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 46.7 21 7884404 (1), 10396621 (1), 11744026 (1), 18535281 (1) (see all 16)
    brain ischemia 40.5 4 9988118 (1), 10355598 (1), 11320597 (1), 8790990 (1)
    cerebral ischemia 36.5 7 8050467 (2), 11320597 (1), 17650627 (1), 8790990 (1) (see all 6)
    carotid occlusion 24.5 1 2364291 (1)
    heart failure congestive 17.8 5 10636259 (1), 11558828 (1), 19804290 (1), 17923351 (1) (see all 5)
    heart failure 17.1 10 17936154 (2), 8822971 (1), 19919976 (1), 20027105 (1) (see all 9)
    transient cerebral ischemia 16.8 3 1666408 (2), 1529167 (1)
    bradycardia 16.6 3 9763631 (1), 9203590 (1), 8276062 (1)
    effects cardiovascular 15.8 2 9988118 (1), 10355598 (1)
    myocardial ischemia 14.2 1 9191496 (1)

    Genetic Association Database (GAD): ADORA1
    Human Genome Epidemiology (HuGE) Navigator: ADORA1 (17 documents)

    Export disorders for ADORA1 gene to outside databases

    Publications
    for ADORA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADORA1 gene, integrated from 9 sources (see all 486):
    (articles sorted by number of sources associating them with ADORA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)1, 4, 9 Wright K....Griffiths L.R. (2004)
    2. Cloning and functional characterization of a human A1 adenosine receptor. (PubMed id 1530647)1, 2, 9 Libert F.... Mendla K.D. (1992)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. (PubMed id 12825092)1, 4 Alsene K....de Wit H. (2003)
    6. Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. (PubMed id 8300646)1, 2 Ren H. and Stiles G.L. (1994)
    7. Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. (PubMed id 1339301)1, 2 Townsend-Nicholson A. and Shine J. (1992)
    8. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PubMed id 1662665)1, 3 Libert F....Mattei M.G. (1991)
    9. Selective amplification and cloning of four new membe rs of the G protein-coupled receptor family. (PubMed id 2541503)1, 3 Libert F....Vassart G. (1989)
    10. Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. (PubMed id 16702031)7, 9 Gaytan S.P....Pasaro R. (2006)

    External Searches for ADORA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADORA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134 HGNC: 262 AceView: ADORA1 Ensembl:ENSG00000163485 euGenes: HUgn134
    ECgene: ADORA1 Kegg: 134 H-InvDB: ADORA1

    Other Databases showing ADORA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADORA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADORA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADORA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADORA1 gene:
    Search GeneIP for patents involving ADORA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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