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Aliases for ADORA1 Gene

Aliases for ADORA1 Gene

  • Adenosine A1 Receptor 2 3
  • RDC7 3 6
  • Adenosine A1 Receptor Variant 1 3
  • Adenosine Receptor A1 3

External Ids for ADORA1 Gene

Previous GeneCards Identifiers for ADORA1 Gene

  • GC01P200742
  • GC01P198489
  • GC01P199526
  • GC01P200348
  • GC01P199791
  • GC01P201326
  • GC01P174262

Summaries for ADORA1 Gene

Entrez Gene Summary for ADORA1 Gene

  • The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA1 Gene

ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include brain ischemia and retinal ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and G-protein beta/gamma-subunit complex binding. An important paralog of this gene is GPR119.

UniProtKB/Swiss-Prot for ADORA1 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

Tocris Summary for ADORA1 Gene

  • The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. They display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and esophagus.

Gene Wiki entry for ADORA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA1 Gene

Genomics for ADORA1 Gene

Regulatory Elements for ADORA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADORA1 Gene

203,090,654 bp from pter
203,167,405 bp from pter
76,752 bases
Plus strand

Genomic View for ADORA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADORA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA1 Gene

Proteins for ADORA1 Gene

  • Protein details for ADORA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine receptor A1
    Protein Accession:
    Secondary Accessions:
    • A6NFY5
    • A6NGP4
    • A8K1L3
    • B3KXQ4
    • D2CGD0
    • Q6FHK3
    • Q8TAM8

    Protein attributes for ADORA1 Gene

    326 amino acids
    Molecular mass:
    36512 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADORA1 Gene


neXtProt entry for ADORA1 Gene

Proteomics data for ADORA1 Gene at MOPED

Post-translational modifications for ADORA1 Gene

  • Glycosylation at Asn159
  • Modification sites at PhosphoSitePlus

Other Protein References for ADORA1 Gene

Antibody Products

No data available for DME Specific Peptides for ADORA1 Gene

Domains for ADORA1 Gene

Gene Families for ADORA1 Gene

Suggested Antigen Peptide Sequences for ADORA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA1: view

Function for ADORA1 Gene

Molecular function for ADORA1 Gene

GENATLAS Biochemistry:
adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

Gene Ontology (GO) - Molecular Function for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IEA --
GO:0001883 purine nucleoside binding IEA --
GO:0004629 phospholipase C activity IEA --
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with ADORA1: view
genes like me logo Genes that share phenotypes with ADORA1: view

Animal Models for ADORA1 Gene

MGI Knock Outs for ADORA1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ADORA1 Gene

Localization for ADORA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADORA1 Gene COMPARTMENTS Subcellular localization image for ADORA1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1530647
GO:0012505 endomembrane system --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Pathways for ADORA1 Gene

genes like me logo Genes that share pathways with ADORA1: view

Pathways by source for ADORA1 Gene

1 GeneGo (Thomson Reuters) pathway for ADORA1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001659 temperature homeostasis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Drugs for ADORA1 Gene

(13) Drugbank Compounds for ADORA1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
58-61-7 60961 Target agonist approved, investigational
83712-60-1 Target approved, investigational
  • 1-(Aminomethyl)cyclohexaneacetic acid
60142-96-3 3446 Target agonist approved, investigational
  • Oxpentifylline
6493-05-6 4740 Target antagonist approved, investigational
  • Aminophyllin
317-34-0 9433 Target antagonist approved

(5) Tocris Compounds for ADORA1 Gene

Compound Action Cas Number
2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist [37739-05-2]
2'-MeCCPA Very selective and potent A1 receptor agonist [205171-12-6]
DPCPX A1 selective antagonist [102146-07-6]
PSB 36 Potent and selective A1 antagonist [524944-72-7]
SLV 320 Potent and selective A1 antagonist [251945-92-3]

(7) ApexBio Compounds for ADORA1 Gene

Compound Action Cas Number
Adenine HCl Adenine receptor agonist [2922-28-3]
CGS 21680 HCl A2 adenosine receptor agonist [124431-80-7]
Istradefylline (KW-6002) Selective A2A receptor antagonist [155270-99-8]
Paeoniflorin Activator of adenosine A1 receptor;glycoside found in peony root [23180-57-6]
Preladenant Adenosine A2A receptor antagonist [377727-87-2]
Ticlopidine HCl [53885-35-1]
Valsartan Angiotensin II AT1 receptor antagonist [137862-53-4]

(10) HMDB Compounds for ADORA1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
  • Aminophyllin
  • 1,3,7-Trimethyl-2,6-dioxopurine
  • Dihydroxypropyl Theophylline
  • Neurontin

(65) IUPHAR Ligand for ADORA1 Gene

Ligand Type Action Affinity Pubmed IDs
SCH4421416 Antagonist Antagonist 10.3
CGS 15943 Antagonist Antagonist 9.4
apadenoson Agonist Agonist 9.3
SCH 58261 Antagonist Antagonist 9.2
[3H]CCPA Agonist Full agonist 9.2
[3H]DPCPX Antagonist Antagonist 9.2
ZM-241385 Antagonist Antagonist 9.1
preladenant Antagonist Antagonist 9.05
XAC Antagonist Antagonist 9
FR194921 Antagonist Antagonist 8.9
BIIB014 Antagonist Antagonist 8.89
NECA Agonist Full agonist 8.7
(R,S)-PHPNECA Agonist Full agonist 8.5
2-hexynyl-NECA Agonist Full agonist 8.3
MSX-2 Antagonist Antagonist 8.27
ST-1535 Antagonist Antagonist 8.18
CGS 21680 Agonist Full agonist 8.1
CPT Antagonist Antagonist 8
istradefylline Antagonist Antagonist 7.92
LUF5831 Agonist Partial agonist 7.7
DPCPX Antagonist Antagonist 7.2
rolofylline Antagonist Antagonist 6.97
MRE 3008F20 Antagonist Antagonist 6.8
2-chloroadenosine Agonist Full agonist 6.8
LUF5981 Antagonist Antagonist 6.71
TCPA Agonist Agonist 6.68
AS70 Antagonist Antagonist 6.6
binodenoson Agonist Agonist 6.57
regadenoson Agonist Agonist 6.54
AS100 Antagonist Antagonist 6.5
SLV320 Antagonist Antagonist 6.4
KF26777 Antagonist Antagonist 6.33
IB-MECA Agonist Full agonist 6.3
MRS1754 Antagonist Antagonist 6.3
(R)-PIA Agonist Full agonist 6.2
PENECA Agonist Full agonist 6.2
L-97-1 Antagonist Antagonist 6.2
ATL802 Antagonist Antagonist 6.18
cyclopentyladenosine Agonist Full agonist 6.1
AS99 Antagonist Antagonist 6.1
CPFPX Antagonist Antagonist 6.03
LAS38096 Antagonist Antagonist 6
MRE 2029F20 Antagonist Antagonist 6
HEMADO Agonist Agonist 5.92
FK-453 Antagonist Antagonist 5.89
PSB-11 Antagonist Antagonist 5.89
theophylline Antagonist Antagonist 5.8
MRS3558 Agonist Agonist 5.63
CCPA Agonist Full agonist 5.6
PSB-10 Antagonist Antagonist 5.57
CVT-6883 Antagonist Antagonist 5.48
MRS1523 Antagonist Antagonist 5.44
Cl-IB-MECA Agonist Agonist 5.27
tonapofylline Antagonist Antagonist 5.19
CP608,039 Agonist Agonist 5.14
(S)-PIA Agonist Full agonist 5.1
IBMX Antagonist Antagonist 5.1
MRS5151 Agonist Agonist 5
MRS1191 Antagonist Antagonist 5
PSB603 Antagonist Antagonist 5
GS9667 Agonist Agonist 5
Bay60-6583 Agonist Agonist 5
PSB1115 Antagonist Antagonist 5
adenosine Channel blocker None 3.2
caffeine Activator None

(89) Novoseek inferred chemical compound relationships for ADORA1 Gene

Compound -log(P) Hits PubMed IDs
dpcpx 93.4 55
n6-cyclopentyladenosine 93.3 27
tecadenoson 89.4 2
8-cyclopentyltheophylline 88.6 12
n(6)-cyclohexyladenosine 87.9 13

(1) PharmGKB related drug/compound annotations for ADORA1 Gene

Drug/compound Annotation
aspirin Clinical Annotation
genes like me logo Genes that share compounds with ADORA1: view

Compound Products

Transcripts for ADORA1 Gene

Unigene Clusters for ADORA1 Gene

Adenosine A1 receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADORA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP9: - - - - - - -
SP10: - - -
SP11: -

Relevant External Links for ADORA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADORA1 Gene

mRNA expression in normal human tissues for ADORA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA1 Gene

This gene is overexpressed in Brain - Cortex (4.3) and Brain - Spinal cord (cervical c-1) (4.1).

Protein differential expression in normal tissues for ADORA1 Gene

This gene is overexpressed in Frontal cortex (39.3), Retina (18.0), and Testis (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADORA1 Gene

SOURCE GeneReport for Unigene cluster for ADORA1 Gene Hs.77867

genes like me logo Genes that share expressions with ADORA1: view

Expression partners for ADORA1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADORA1 Gene

Orthologs for ADORA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADORA1 35
  • 91.1 (n)
  • 94.48 (a)
  • 94 (a)
(Canis familiaris)
Mammalia ADORA1 35
  • 91.62 (n)
  • 94.17 (a)
  • 94 (a)
(Mus musculus)
Mammalia Adora1 35
  • 88.65 (n)
  • 94.79 (a)
Adora1 16
Adora1 36
  • 95 (a)
(Pan troglodytes)
Mammalia ADORA1 35
  • 99.59 (n)
  • 99.69 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Adora1 35
  • 88.96 (n)
  • 94.79 (a)
(Monodelphis domestica)
Mammalia ADORA1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ADORA1 36
  • 45 (a)
(Gallus gallus)
Aves ADORA1 35
  • 78.61 (n)
  • 81.62 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia ADORA1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adora1 35
  • 67.52 (n)
  • 72.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia adora1-A 35
(Danio rerio)
Actinopterygii adora1 35
  • 68.23 (n)
  • 68.75 (a)
adora1 36
  • 63 (a)
ADORA1 (1 of 2) 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9753 37
  • 34 (a)
AdoR 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for ADORA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA1 Gene

Gene Tree for ADORA1 (if available)
Gene Tree for ADORA1 (if available)

Paralogs for ADORA1 Gene

Paralogs for ADORA1 Gene

(3) SIMAP similar genes for ADORA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADORA1: view

Variants for ADORA1 Gene

Sequence variations from dbSNP and Humsavar for ADORA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11584369 -- 203,148,895(+) TTTTT(A/T)AGACG intron-variant
rs11580618 -- 203,135,766(+) ACCCA(G/T)TAAAT intron-variant
rs11579990 -- 203,164,422(+) ATCCA(C/T)GTATG intron-variant
rs11576067 -- 203,164,133(+) CGCCC(A/G)ACCCT intron-variant
rs11547177 -- 203,128,849(+) GCCGC(A/C)CTCCA missense, reference, intron-variant, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADORA1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV Loss 17160897
nsv873109 CNV Gain 21882294

Relevant External Links for ADORA1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA1 Gene

Disorders for ADORA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADORA1 Gene in MalaCards »

(4) Diseases for ADORA1 Gene

(1) University of Copenhagen DISEASES for ADORA1 Gene

(42) Novoseek inferred disease relationships for ADORA1 Gene

Disease -log(P) Hits PubMed IDs
ischemia 46.7 16
brain ischemia 40.5 4
cerebral ischemia 36.5 7
carotid occlusion 24.5 1
heart failure congestive 17.8 5

Relevant External Links for ADORA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADORA1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADORA1 Gene

Publications for ADORA1 Gene

  1. Cloning and functional characterization of a human A1 adenosine receptor. (PMID: 1530647) Libert F. … Mendla K.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  2. A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. (PMID: 17438146) Funakoshi H. … Feldman A.M. (Circulation 2007) 23 25 26
  3. Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. (PMID: 16702031) Gaytan S.P. … PA!saro R. (Auton Neurosci 2006) 23 25 26
  4. Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection. (PMID: 14992338) Nantwi K.D. … Goshgarian H.G. (J Spinal Cord Med 2003) 23 25 26
  5. Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects. (PMID: 8425287) Lerman B.B. (Circulation 1993) 23 25 26

Products for ADORA1 Gene

Sources for ADORA1 Gene

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