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Aliases for ADORA1 Gene

Aliases for ADORA1 Gene

  • Adenosine A1 Receptor 2 3 5
  • Adenosine A1 Receptor Variant 1 3
  • Adenosine A1 Receptor Variant 2 3
  • Adenosine Receptor A1 3
  • RDC7 3

External Ids for ADORA1 Gene

Previous GeneCards Identifiers for ADORA1 Gene

  • GC01P200742
  • GC01P198489
  • GC01P199526
  • GC01P200348
  • GC01P199791
  • GC01P201326
  • GC01P174262

Summaries for ADORA1 Gene

Entrez Gene Summary for ADORA1 Gene

  • The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADORA1 Gene

ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include Brain Ischemia and Ischemia. Among its related pathways are Nucleotide-like (purinergic) receptors and Regulation of lipolysis in adipocytes. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is ADORA2A.

UniProtKB/Swiss-Prot for ADORA1 Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Tocris Summary for ADORA1 Gene

  • The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.

Gene Wiki entry for ADORA1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA1 Gene

Genomics for ADORA1 Gene

Regulatory Elements for ADORA1 Gene

Enhancers for ADORA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G203199 1.4 Ensembl ENCODE dbSUPER 21.6 +110.9 110932 4.8 PKNOX1 RAD21 YY1 SCRT2 ZNF143 FOS ZNF263 ZNF654 HCFC1 CEBPB MYBPH ADORA1 ENSG00000224671 ENSG00000234775 MYOG FMOD LOC100131747 OPTC CHIT1 CHI3L1
GH01G203169 1.5 Ensembl ENCODE dbSUPER 16.1 +83.6 83648 9.6 PKNOX1 YBX1 GLIS2 ZNF143 FOS DEK SP5 JUNB REST SMARCA4 ADORA1 ENSG00000224671 FMOD LOC100131747 UBE2T CHI3L1 MYBPH
GH01G203035 1.7 Ensembl ENCODE dbSUPER 11.6 -52.5 -52541 6.2 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D GLIS1 SNRPE MYOG ADORA1 PPFIA4 CYB5R1 MYBPH CHI3L1 ENSG00000224671 LOC100506672 ZBED6
GH01G203132 0.8 dbSUPER 23.7 +44.7 44684 4.7 CTCF PKNOX1 ESRRA NFIB HINFP BACH1 MAX ZNF121 ZNF316 FOS ADORA1 MYBPH MYOG CHI3L1 LGR6 ENSG00000234775 ENSG00000224671
GH01G203266 1.4 Ensembl ENCODE dbSUPER 10.7 +176.9 176878 1.4 HDGF ZNF2 ZNF48 ZNF766 ZNF143 DEK REST TBX21 ZNF579 MAFF BTG2 LINC01136 RNU6-487P PPFIA4 FMOD LOC100131747 ADORA1 ENSG00000224671 OPTC CHI3L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADORA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADORA1 Gene

Chromosome:
1
Start:
203,090,654 bp from pter
End:
203,167,405 bp from pter
Size:
76,752 bases
Orientation:
Plus strand

Genomic View for ADORA1 Gene

Genes around ADORA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA1 Gene

Proteins for ADORA1 Gene

  • Protein details for ADORA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30542-AA1R_HUMAN
    Recommended name:
    Adenosine receptor A1
    Protein Accession:
    P30542
    Secondary Accessions:
    • A6NFY5
    • A6NGP4
    • A8K1L3
    • B3KXQ4
    • D2CGD0
    • Q6FHK3
    • Q8TAM8

    Protein attributes for ADORA1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36512 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADORA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADORA1 Gene

Post-translational modifications for ADORA1 Gene

  • Glycosylation at Asn159
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADORA1 Gene

Domains & Families for ADORA1 Gene

Gene Families for ADORA1 Gene

Suggested Antigen Peptide Sequences for ADORA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30542

UniProtKB/Swiss-Prot:

AA1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA1: view

Function for ADORA1 Gene

Molecular function for ADORA1 Gene

GENATLAS Biochemistry:
adenosine receptor A1,G protein coupled receptor superfamily,with no likely role of promoters polymorphism in bipolar affective disorders inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001609 G-protein coupled adenosine receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IEA --
GO:0001883 purine nucleoside binding IEA --
GO:0004629 phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with ADORA1: view
genes like me logo Genes that share phenotypes with ADORA1: view

Animal Models for ADORA1 Gene

MGI Knock Outs for ADORA1:

Animal Model Products

CRISPR Products

miRNA for ADORA1 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA1 Gene

Localization for ADORA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADORA1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 3
extracellular 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 1530647
GO:0012505 endomembrane system IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with ADORA1: view

Pathways & Interactions for ADORA1 Gene

genes like me logo Genes that share pathways with ADORA1: view

Gene Ontology (GO) - Biological Process for ADORA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0001659 temperature homeostasis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
genes like me logo Genes that share ontologies with ADORA1: view

No data available for SIGNOR curated interactions for ADORA1 Gene

Drugs & Compounds for ADORA1 Gene

(170) Drugs for ADORA1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, antagonist, Target 64
Caffeine Approved Nutra Antagonist, antagonist, Target, multitarget A1 and A2B antagonist. CNS stimulant 396
Adenosine Approved, Investigational Pharma Agonist, agonist, Target 419
Aminophylline Approved Pharma Target, antagonist 25
Dyphylline Approved Pharma Target, antagonist 0

(44) Additional Compounds for ADORA1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IBMX
Antagonist 28822-58-4
CPT
Antagonist
SCH4421416
Antagonist
(+-)-5'-Chloro-5'-deoxy-ENBA
103626-26-2

(5) Tocris Compounds for ADORA1 Gene

Compound Action Cas Number
(+-)-5'-Chloro-5'-deoxy-ENBA Highly selective A1 agonist 103626-26-2
2-Chloro-N6-cyclopentyladenosine Potent, selective A1 agonist 37739-05-2
2'-MeCCPA Very selective and potent A1 receptor agonist 205171-12-6
DPCPX A1 selective antagonist 102146-07-6
N6-Cyclopentyladenosine Potent, selective A1 agonist 41552-82-3

(54) ApexBio Compounds for ADORA1 Gene

Compound Action Cas Number
(±)-5'-Chloro-5'-deoxy-ENBA adenosine A1 receptor agonist, selective and high-affinity 103626-26-2
1,3-Dipropyl-8-phenylxanthine 85872-53-3
2-Chloroadenosine 146-77-0
2-Chloro-N6-cyclopentyladenosine adenosine A1 receptor agonist, potent and selective 37739-05-2
2-Cl-IB-MECA 163042-96-4
2'-MeCCPA 205171-12-6
8-(3-Chlorostyryl)caffeine 147700-11-6
8-Aminoadenine Adenine receptor agonist 28128-33-8
Adenine HCl Adenine receptor agonist 2922-28-3
Aminophylline 317-34-0
Capadenoson Adenosine A1 receptor agonist 544417-40-5
CGH 2466 dihydrochloride Antagonist of adenosine A1/A2B/A3 receptor and p38 MAPK inhibitor 1177618-54-0
CGS 15943 104615-18-1
CGS 21680 HCl A2 adenosine receptor agonist 124431-80-7
CV 1808 53296-10-9
DPCPX 102146-07-6
Dyphylline 479-18-5
GR 79236 adenosine A1 receptor agonist 124555-18-6
HEMADO 403842-38-6
Istradefylline (KW-6002) Selective A2A receptor antagonist 155270-99-8
KW 3902 136199-02-5
Lu AA 47070 913842-25-8
LUF 5834 333962-91-7
MRE 3008F20 252979-43-4
MRS 1220 183721-15-5
MRS 1334 192053-05-7
MRS 1706 264622-53-9
MRS 1754 264622-58-4
MRS 3777 hemioxalate
N6-Cyclopentyladenosine 41552-82-3
NECA adenosine receptor agonist, non-selective 35920-39-9
Nicergoline 27848-84-6
Paeoniflorin Activator of adenosine A1 receptor;glycoside found in peony root 23180-57-6
PD 81723 132861-87-1
Preladenant Adenosine A2A receptor antagonist 377727-87-2
PSB 0777 ammonium salt
PSB 0788 1027513-54-7
PSB 10 hydrochloride 591771-91-4
PSB 11 hydrochloride 453591-58-7
PSB 1115 152529-79-8
PSB 36 524944-72-7
PSB 603 1092351-10-4
SCH 442416 316173-57-6
SCH 58261 160098-96-4
SDZ WAG 994 130714-47-5
SLV 320 251945-92-3
TC-G 1004 1061747-72-5
Ticlopidine HCl 53885-35-1
UK 14,304 59803-98-4
Valsartan Angiotensin II AT1 receptor antagonist 137862-53-4
VUF 5574 280570-45-8
XAC 96865-92-8
XCC 96865-83-7
ZM 241385 139180-30-6
genes like me logo Genes that share compounds with ADORA1: view

Drug Products

Transcripts for ADORA1 Gene

Unigene Clusters for ADORA1 Gene

Adenosine A1 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9: - - - - - - -
SP10: - - -
SP11: -

Relevant External Links for ADORA1 Gene

GeneLoc Exon Structure for
ADORA1
ECgene alternative splicing isoforms for
ADORA1

Expression for ADORA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADORA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADORA1 Gene

This gene is overexpressed in Brain - Cortex (x4.3) and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for ADORA1 Gene

This gene is overexpressed in Frontal cortex (39.3), Retina (18.0), and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADORA1 Gene



Protein tissue co-expression partners for ADORA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADORA1 Gene:

ADORA1

SOURCE GeneReport for Unigene cluster for ADORA1 Gene:

Hs.77867

Evidence on tissue expression from TISSUES for ADORA1 Gene

  • Nervous system(5)
  • Heart(4.5)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ADORA1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADORA1 Gene

Orthologs for ADORA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADORA1 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ADORA1 34 35
  • 91.62 (n)
cow
(Bos Taurus)
Mammalia ADORA1 34 35
  • 91.1 (n)
rat
(Rattus norvegicus)
Mammalia Adora1 34
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Adora1 34 16 35
  • 88.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ADORA1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADORA1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADORA1 34 35
  • 78.61 (n)
lizard
(Anolis carolinensis)
Reptilia ADORA1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adora1 34
  • 67.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia adora1-A 34
zebrafish
(Danio rerio)
Actinopterygii adora1 34 35
  • 68.23 (n)
ADORA1 (1 of 2) 35
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9753 36
  • 34 (a)
AdoR 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ador-1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for ADORA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA1 Gene

ENSEMBL:
Gene Tree for ADORA1 (if available)
TreeFam:
Gene Tree for ADORA1 (if available)

Paralogs for ADORA1 Gene

Paralogs for ADORA1 Gene

(3) SIMAP similar genes for ADORA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADORA1: view

Variants for ADORA1 Gene

Sequence variations from dbSNP and Humsavar for ADORA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035754 A colorectal cancer sample
rs1000025047 -- 203,164,092(+) GATTG(A/G)TTTAA intron-variant
rs1000056875 -- 203,141,682(+) TTCAA(C/G)TGATT intron-variant
rs1000076697 -- 203,135,412(+) CCAAC(A/G)CTTTG intron-variant
rs1000077346 -- 203,164,432(+) GCATG(C/G/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADORA1 Gene

Variant ID Type Subtype PubMed ID
nsv832370 CNV loss 17160897
nsv952639 CNV deletion 24416366

Variation tolerance for ADORA1 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADORA1 Gene

Human Gene Mutation Database (HGMD)
ADORA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADORA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA1 Gene

Disorders for ADORA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADORA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain ischemia
ischemia
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADORA1

Genetic Association Database (GAD)
ADORA1
Human Genome Epidemiology (HuGE) Navigator
ADORA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADORA1
genes like me logo Genes that share disorders with ADORA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADORA1 Gene

Publications for ADORA1 Gene

  1. Cloning and functional characterization of a human A1 adenosine receptor. (PMID: 1530647) Libert F. … Mendla K.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 22 64
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PMID: 20392501) Gass N. … Paunio T. (J Affect Disord 2010) 3 46 64
  5. Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI. (PMID: 20609566) Wagner A.K. … Conley Y.P. (Epilepsy Res. 2010) 3 46 64

Products for ADORA1 Gene

Sources for ADORA1 Gene

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