Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADO Gene

Aliases for ADO Gene

  • 2-Aminoethanethiol (Cysteamine) Dioxygenase 2 3
  • Cysteamine Dioxygenase 2 3 4
  • C10orf22 3 4 6
  • Cysteamine (2-Aminoethanethiol) Dioxygenase (ADO) 3
  • Chromosome 10 Open Reading Frame 22 2
  • 2-Aminoethanethiol Dioxygenase 3
  • EC 4

External Ids for ADO Gene

Previous HGNC Symbols for ADO Gene

  • C10orf22

Previous GeneCards Identifiers for ADO Gene

  • GC10P064235
  • GC10P064564
  • GC10P058556

Summaries for ADO Gene

Entrez Gene Summary for ADO Gene

  • Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADO Gene

ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase) is a Protein Coding gene. Diseases associated with ADO include ewing sarcoma. Among its related pathways are Metabolism and Taurine and hypotaurine metabolism. GO annotations related to this gene include cysteamine dioxygenase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADO Gene

Genomics for ADO Gene

Regulatory Elements for ADO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADO Gene

62,804,756 bp from pter
62,808,483 bp from pter
3,728 bases
Plus strand

Genomic View for ADO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADO Gene

Proteins for ADO Gene

  • Protein details for ADO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-aminoethanethiol dioxygenase
    Protein Accession:
    Secondary Accessions:
    • B1AL29

    Protein attributes for ADO Gene

    270 amino acids
    Molecular mass:
    29751 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    • Sequence=BAB55123.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADO Gene

Proteomics data for ADO Gene at MOPED

Post-translational modifications for ADO Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Other Protein References for ADO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADO Gene

Domains for ADO Gene

Protein Domains for ADO Gene

Suggested Antigen Peptide Sequences for ADO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ADO Gene

Function for ADO Gene

Molecular function for ADO Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-aminoethanethiol + O(2) = hypotaurine.

Enzyme Numbers (IUBMB) for ADO Gene

Gene Ontology (GO) - Molecular Function for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0047800 cysteamine dioxygenase activity IEA --
genes like me logo Genes that share ontologies with ADO: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADO

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ADO Gene

Localization for ADO Gene

Subcellular locations from

Jensen Localization Image for ADO Gene COMPARTMENTS Subcellular localization image for ADO gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ADO: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADO Gene

Pathways for ADO Gene

genes like me logo Genes that share pathways with ADO: view

Pathways by source for ADO Gene

Interacting Proteins for ADO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362888 for ADO Gene via STRING

Gene Ontology (GO) - Biological Process for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADO: view

Drugs for ADO Gene

(4) HMDB Compounds for ADO Gene

Compound Synonyms Cas Number PubMed IDs
  • (2-Mercaptoethyl)amine
  • Armco iron
  • 2-Amino-Ethanesulfinate
  • Dioxygen
genes like me logo Genes that share compounds with ADO: view

Transcripts for ADO Gene

mRNA/cDNA for ADO Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(173) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADO Gene

2-aminoethanethiol (cysteamine) dioxygenase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADO Gene

No ASD Table

Relevant External Links for ADO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADO Gene

mRNA expression in normal human tissues for ADO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ADO Gene

This gene is overexpressed in Uterus (9.0) and Lymph node (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADO Gene

SOURCE GeneReport for Unigene cluster for ADO Gene Hs.99821

genes like me logo Genes that share expressions with ADO: view

Expression partners for ADO Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADO Gene

Orthologs for ADO Gene

This gene was present in the common ancestor of animals.

Orthologs for ADO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADO 35
  • 90.74 (n)
  • 90.74 (a)
ADO 36
  • 90 (a)
(Canis familiaris)
Mammalia ADO 35
  • 92.1 (n)
  • 92.96 (a)
ADO 36
  • 93 (a)
(Mus musculus)
Mammalia Ado 35
  • 87.5 (n)
  • 89.45 (a)
Ado 16
Ado 36
  • 89 (a)
(Pan troglodytes)
Mammalia ADO 35
  • 99.88 (n)
  • 100 (a)
ADO 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ado 35
  • 85.55 (n)
  • 88.28 (a)
(Monodelphis domestica)
Mammalia ADO 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ADO 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ado 35
  • 65.59 (n)
  • 59.27 (a)
(Danio rerio)
Actinopterygii -- 35
adoa 35
  • 60.57 (n)
  • 60.16 (a)
adoa 36
  • 58 (a)
adob 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006807 35
  • 54.78 (n)
  • 39.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7550 35
  • 47.72 (n)
  • 36.04 (a)
CG7550 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y50D4C.6 36
  • 25 (a)
Species with no ortholog for ADO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADO Gene

Gene Tree for ADO (if available)
Gene Tree for ADO (if available)

Paralogs for ADO Gene

No data available for Paralogs for ADO Gene

Variants for ADO Gene

Sequence variations from dbSNP and Humsavar for ADO Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs569705 - 62,805,855(+) CAGGT(C/T)CCAAG reference, missense
rs10995311 - 62,805,174(+) CTGGC(C/G)CGGAG reference, missense
rs2236295 - 62,805,132(+) GCAGC(G/T)GGGGC reference, missense
rs577951319 -- 62,807,691(+) CCACA(-/T)TCTGG utr-variant-3-prime
rs577042359 -- 62,807,328(+) CACAT(C/T)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADO Gene

Variant ID Type Subtype PubMed ID
nsv895570 CNV Loss 21882294

Relevant External Links for ADO Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADO Gene

Disorders for ADO Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADO Gene in MalaCards »

(1) Disease for ADO Gene

(3) University of Copenhagen DISEASES for ADO Gene

Relevant External Links for ADO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADO: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ADO Gene

Publications for ADO Gene

  1. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. (PMID: 17581819) Dominy J.E. Jr. … Stipanuk M.H. (J. Biol. Chem. 2007) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ADO Gene

Sources for ADO Gene

Back to Top