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Aliases for ADO Gene

Aliases for ADO Gene

  • 2-Aminoethanethiol (Cysteamine) Dioxygenase 2 3 5
  • Cysteamine Dioxygenase 2 3 4
  • C10orf22 3 4
  • Cysteamine (2-Aminoethanethiol) Dioxygenase (ADO) 3
  • Chromosome 10 Open Reading Frame 22 2
  • EC 4

External Ids for ADO Gene

Previous HGNC Symbols for ADO Gene

  • C10orf22

Previous GeneCards Identifiers for ADO Gene

  • GC10P064235
  • GC10P064564
  • GC10P058556

Summaries for ADO Gene

Entrez Gene Summary for ADO Gene

  • Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADO Gene

ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase) is a Protein Coding gene. Diseases associated with ADO include Acrodysostosis. Among its related pathways are Taurine and hypotaurine metabolism and Sulfur amino acid metabolism. GO annotations related to this gene include cysteamine dioxygenase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADO Gene

Genomics for ADO Gene

Regulatory Elements for ADO Gene

Enhancers for ADO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADO on UCSC Golden Path with GeneCards custom track

Promoters for ADO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADO on UCSC Golden Path with GeneCards custom track

Genomic Location for ADO Gene

62,804,756 bp from pter
62,808,483 bp from pter
3,728 bases
Plus strand

Genomic View for ADO Gene

Genes around ADO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADO Gene

Proteins for ADO Gene

  • Protein details for ADO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-aminoethanethiol dioxygenase
    Protein Accession:
    Secondary Accessions:
    • B1AL29

    Protein attributes for ADO Gene

    270 amino acids
    Molecular mass:
    29751 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    • Sequence=BAB55123.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADO Gene

Proteomics data for ADO Gene at MOPED

Post-translational modifications for ADO Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for ADO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADO Gene

Domains & Families for ADO Gene

Protein Domains for ADO Gene

Suggested Antigen Peptide Sequences for ADO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ADO Gene

Function for ADO Gene

Molecular function for ADO Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-aminoethanethiol + O(2) = hypotaurine.

Enzyme Numbers (IUBMB) for ADO Gene

Gene Ontology (GO) - Molecular Function for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047800 cysteamine dioxygenase activity IEA,TAS --
genes like me logo Genes that share ontologies with ADO: view

Phenotypes for ADO Gene

genes like me logo Genes that share phenotypes with ADO: view

Animal Model Products

miRNA for ADO Gene

miRTarBase miRNAs that target ADO

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADO Gene

Localization for ADO Gene

Subcellular locations from

Jensen Localization Image for ADO Gene COMPARTMENTS Subcellular localization image for ADO gene
Compartment Confidence
mitochondrion 4
cytosol 2
extracellular 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
genes like me logo Genes that share ontologies with ADO: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADO Gene

Pathways & Interactions for ADO Gene

genes like me logo Genes that share pathways with ADO: view

Pathways by source for ADO Gene

Interacting Proteins for ADO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362888 for ADO Gene via STRING

Gene Ontology (GO) - Biological Process for ADO Gene


No data available for SIGNOR curated interactions for ADO Gene

Drugs & Compounds for ADO Gene

(1) Drugs for ADO Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma 26

(3) Additional Compounds for ADO Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • 2-Amino-Ethanesulfinate
  • 2-Amino-Ethanesulfinic acid
  • 2-Aminoethanesulfinate
  • 2-Aminoethanesulfinic acid
  • 2-Aminoethylsulfinate
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
genes like me logo Genes that share compounds with ADO: view

Transcripts for ADO Gene

mRNA/cDNA for ADO Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(173) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADO Gene

2-aminoethanethiol (cysteamine) dioxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADO Gene

No ASD Table

Relevant External Links for ADO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADO Gene

mRNA expression in normal human tissues for ADO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADO Gene

This gene is overexpressed in Uterus (9.0) and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADO Gene

SOURCE GeneReport for Unigene cluster for ADO Gene Hs.99821

genes like me logo Genes that share expression patterns with ADO: view

Protein tissue co-expression partners for ADO Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADO Gene

Orthologs for ADO Gene

This gene was present in the common ancestor of animals.

Orthologs for ADO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADO 35
  • 90.74 (n)
  • 90.74 (a)
ADO 36
  • 90 (a)
(Canis familiaris)
Mammalia ADO 35
  • 92.1 (n)
  • 92.96 (a)
ADO 36
  • 93 (a)
(Mus musculus)
Mammalia Ado 35
  • 87.5 (n)
  • 89.45 (a)
Ado 16
Ado 36
  • 89 (a)
(Pan troglodytes)
Mammalia ADO 35
  • 99.88 (n)
  • 100 (a)
ADO 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ado 35
  • 85.55 (n)
  • 88.28 (a)
(Monodelphis domestica)
Mammalia ADO 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ADO 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ado 35
  • 65.59 (n)
  • 59.27 (a)
(Danio rerio)
Actinopterygii -- 35
adoa 35
  • 60.57 (n)
  • 60.16 (a)
adoa 36
  • 58 (a)
adob 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006807 35
  • 54.78 (n)
  • 39.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7550 35
  • 47.72 (n)
  • 36.04 (a)
CG7550 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y50D4C.6 36
  • 25 (a)
Species with no ortholog for ADO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADO Gene

Gene Tree for ADO (if available)
Gene Tree for ADO (if available)

Paralogs for ADO Gene

No data available for Paralogs for ADO Gene

Variants for ADO Gene

Sequence variations from dbSNP and Humsavar for ADO Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2236295 - 62,805,132(+) GCAGC(G/T)GGGGC reference, missense
rs10995311 - 62,805,174(+) CTGGC(C/G)CGGAG reference, missense
rs569705 - 62,805,855(+) CAGGT(C/T)CCAAG reference, missense
rs1509964 -- 62,807,604(-) GGCAT(A/G)TCCTG utr-variant-3-prime
rs8331 -- 62,808,205(-) GTTAT(A/T)TTTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADO Gene

Variant ID Type Subtype PubMed ID
nsv895570 CNV Loss 21882294

Variation tolerance for ADO Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.91; 93.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADO Gene

Disorders for ADO Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADO Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search ADO in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADO Gene

Publications for ADO Gene

  1. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. (PMID: 17581819) Dominy J.E. Jr. … Stipanuk M.H. (J. Biol. Chem. 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. (PMID: 25108386) Hou S. … Yang P. (Nat. Genet. 2014) 3
  5. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PMID: 22327514) Postel-Vinay S. … Delattre O. (Nat. Genet. 2012) 3

Products for ADO Gene

Sources for ADO Gene