ADO Gene
protein-coding GIFtS: 50
GCID: GC10P064564
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2-aminoethanethiol (cysteamine) dioxygenase(Previous name: chromosome 10 open reading frame 22 )
(Previous symbol: C10orf22)
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Aliases
for ADO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 2-Aminoethanethiol (Cysteamine) Dioxygenase1 2 | | Chromosome 10 Open Reading Frame 221 | | C10orf221 2 3 | | 2-Aminoethanethiol Dioxygenase2 | | Cysteamine Dioxygenase2 3 | | Cysteamine (2-Aminoethanethiol) Dioxygenase (ADO)2 | | FLJ145471 | | EC 1.13.11.193 |
Export aliases for ADO gene to outside databasesPrevious GC identifers: GC10P064235 GC10P058556 |
Summaries
for ADO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADO:
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase(ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine toform hypotaurine (Dominy et al., 2007 (PubMed 17581819)).(supplied by OMIM, Mar 2008)
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Genomic Views
for ADO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADO gene promoter:
Tal-1 NF-kappaB HNF-1A E47 Gfi-1 CREB deltaCREB HNF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q21.3ADO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P064564: view genomic region
(about GC identifiers)
Start:
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64,564,516 bp from pter |
End:
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64,568,239 bp from pter |
Size:
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3,724 bases |
Orientation:
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plus strand |
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Proteins
for ADO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AEDO_HUMAN, Q96SZ5 (See
protein sequence)Recommended Name: 2-aminoethanethiol dioxygenase Size: 270 amino acids; 29751 Da
Cofactor: Iron (By similarity)
Sequence caution: Sequence=BAB55123.1; Type=Erroneous initiation;
Secondary accessions: B1AL29Explore the universe of human proteins at neXtProt for ADO: NX_Q96SZ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SZ5
ADO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116193.2
ENSEMBL proteins: ENSP00000362888
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
ADO for ontologies About GeneDecksing
ADO Antibody Products:
Assay Products for ADO: |
Protein
Domains /
Families
for ADO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADO for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SZ5ProtoNet protein and cluster: Q96SZ5 1 Blocks protein family: IPB012864 Protein of unknown function DUF1637
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Function
for ADO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: AEDO_HUMAN, Q96SZ5Catalytic activity: 2-aminoethanethiol + O(2) = hypotaurineEnzyme Number (IUBMB): EC 1.13.11.191
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADO (NM_000674) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADO |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- | | GO:0047800 | cysteamine dioxygenase activity |
IEA | -- |
ADO for ontologies About GeneDecksing
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Pathways & Interactions
for ADO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | gamma-glutamyl cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for ADO):
ADO for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADO
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ADO (ENSP000003628884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ADO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADO
4 HMDB Compounds for ADO About this table
Search CenterWatch for drugs/clinical trials and news about ADO / AEDO
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Transcripts
for ADO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADO gene: NM_032804.5 Unigene Cluster for ADO: 2-aminoethanethiol (cysteamine) dioxygenase Hs.99821 [show with all ESTs]Unigene Representative Sequence: NM_0328041 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373783(uc001jmg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ADO (NM_000674) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADO |
Additional cDNA sequence: AK027453.1 AK127694.1 AL049319.1 BC018660.1 BC028589.2 BC067740.1 3 DOTS entries: DT.217168 DT.95171469 DT.91658239 24/173 AceView cDNA sequences (see all 173): AK027453 BX118729 AA382977 BU621225 AA489643 F27255 BM560997 AI359042 BF036875 NM_032804 BQ436923 AI469832 BM717809 BU164906 AA593104 BM682343 AW161420 AW629650 BF431606 BE895944 BC067740 CA413833 BQ022240 AI417565
GeneLoc Exon Structure
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Expression
for ADO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCACTGTT
About this image
See ADO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADO
SOURCE GeneReport for Unigene cluster: Hs.99821
SABiosciences Custom PCR Arrays for ADO
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADO |
Orthologs
for ADO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for ADO gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for ADO (if available)
TreeFam Gene Tree for ADO (if available) |
Paralogs
for ADO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ADO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADO (64564516 - 64568239 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADO: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADO |
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Disorders
/ Diseases
for ADO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADO for disorders About GeneDecksing
OMIM gene information: 611392
OMIM disorders: --
3  diseases for ADO: About MalaCardsosteopetrosis cystic fibrosis fibrosis
3 diseases from the University of Copenhagen DISEASES database for ADO:Patent ductus arteriosus Osteopetrosis Vascular disease Human Genome Epidemiology (HuGE) Navigator: ADO (4 documents)
Export disorders for ADO gene to outside databases
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Publications
for ADO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADO gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ADO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. (PubMed id 17581819)1, 2, 3 Dominy J.E. Jr.... Stipanuk M.H. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Common variants near TARDBP and EGR2 are associated wi th susceptibility to Ewing sarcoma. (PubMed id 22327514)1 Postel-Vinay S....Delattre O. (2012)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
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External Searches for ADO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ADO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ADO gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADO | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/C10orf2 |
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About This Section
| Patent Information for ADO gene:
Search GeneIP for patents involving ADO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for ADO | | OriGene shRNA RFP for ADO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADO | | | OriGene Protein Over-expression Lysate for ADO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADO | | OriGene 3'-UTR Clone for ADO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ADO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADO | | OriGene Custom Protein Services for ADO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADO |
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| | | | Search Tocris compounds for ADO |
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 | | | ADO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADO |
|  |  |  | | | | ThermoFisher Antibodies for ADO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADO |
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