ADNP2 Gene
protein-coding GIFtS: 44
GCID: GC18P077866
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ADNP homeobox 2(Previous name: zinc finger protein 508 )
(Previous symbol: ZNF508)
| |
Aliases
for ADNP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADNP Homeobox 21 2 | | Zinc Finger Protein 5081 2 3 | | ZNF5081 2 3 | | KIAA08631 3 | | ADNP Homeobox Protein 22 |
Export aliases for ADNP2 gene to outside databasesPrevious GC identifers: GC18P075968 GC18P074488 |
Summaries
for ADNP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADNP2_HUMAN, Q6IQ32Function: May be involved in transcriptional regulation
|
Genomic Views
for ADNP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADNP2 gene promoter:
LCR-F1 CBF-C S8 CBF-B CBF-A CP1A CP1C NF-Y Pax-4a CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADNP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23ADNP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P077866: view genomic region
(about GC identifiers)
Start:
|
77,866,915 bp from pter |
End:
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77,905,406 bp from pter |
Size:
|
38,492 bases |
Orientation:
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plus strand |
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Proteins
for ADNP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADNP2_HUMAN, Q6IQ32 (See
protein sequence)Recommended Name: ADNP homeobox protein 2 Size: 1131 amino acids; 122833 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA74886.2; Type=Erroneous initiation; Sequence=BAB14180.1; Type=Frameshift; Positions=466;
Secondary accessions: A8K951 O94943 Q9H9P3Explore the universe of human proteins at neXtProt for ADNP2: NX_Q6IQ32
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IQ32
ADNP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055728.1
ENSEMBL proteins: ENSP00000262198 ENSP00000453418 ENSP00000453275 ENSP00000468397 ENSP00000467370
Human Recombinant Protein Products for ADNP2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ADNP2 for ontologies About GeneDecksing
ADNP2 Antibody Products:
Assay Products for ADNP2: |
Protein
Domains /
Families
for ADNP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADNP2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IQ32ProtoNet protein and cluster: Q6IQ32 UniProtKB/Swiss-Prot: ADNP2_HUMAN, Q6IQ32Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingersSimilarity: Contains 1 homeobox DNA-binding domain |
Function
for ADNP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ADNP2_HUMAN, Q6IQ32Function: May be involved in transcriptional regulation Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
ADNP2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADNP2 (NM_014913) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADNP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP2 |
|
Pathways & Interactions
for ADNP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADNP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for ADNP2 (Q6IQ321, 3 ENSP000002621984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0030182 | neuron differentiation |
ISS | -- | | GO:0030307 | positive regulation of cell growth |
ISS | -- | | GO:0034599 | cellular response to oxidative stress |
ISS | -- | | GO:0060548 | negative regulation of cell death |
ISS | -- |
ADNP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADNP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADNP2
Search CenterWatch for drugs/clinical trials and news about ADNP2
|
Transcripts
for ADNP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADNP2 gene: NM_014913.3 Unigene Cluster for ADNP2: ADNP homeobox 2 Hs.131915 [show with all ESTs]Unigene Representative Sequence: BC0715895 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262198(uc002lnw.3) ENST00000560752 ENST00000559951 ENST00000560561
ENST00000561195
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADNP2 (NM_014913) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADNP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP2 |
Additional cDNA sequence: AB020670.1 AK022688.1 AK023032.1 AK292566.1 BC071589.1 8 DOTS entries: DT.212497 DT.121087656 DT.91744523 DT.100749404 DT.95168931 DT.100733293 DT.121087677 DT.100033852 24/166 AceView cDNA sequences (see all 166): CB960003 AI479487 AI968903 AW673161 BQ891862 BM474860 AI332889 AI567400 AW651700 AI573177 AL553984 CK819847 AI539599 AI587477 BM676632 BM141763 BQ693986 AA301227 BU541415 AI364173 AA553759 AB020670 AW275539 BE900319
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ADNP2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for ADNP2
|
Expression
for ADNP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADNP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTGCTAT
About this image
See ADNP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADNP2
SOURCE GeneReport for Unigene cluster: Hs.131915
SABiosciences Custom PCR Arrays for ADNP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADNP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADNP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP2 |
Orthologs
for ADNP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ADNP2 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADNP21 |
ADNP homeobox 2 |
66.63(n)
62.51(a) |
|
420805 XM_418898.3 XP_418898.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ADNP26 |
-- |
52(a) |
1 ↔ 1 |
4(53239304-53245855) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.171802 |
Xenopus laevis transcribed sequence with weak similarity more |
75.98(n) |
|
AW643056.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
adnp2b6adnp2a6 |
ADNP homeobox 2a |
32(a)31(a) |
1 ↔ many1 ↔ many |
19(21268021-21274770) 16(27612995-27620184) |
ENSEMBL Gene Tree for ADNP2 (if available)
TreeFam Gene Tree for ADNP2 (if available) |
Paralogs
for ADNP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADNP2 gene
- ADNP2
1 SIMAP similar gene for ADNP2 using alignment to 5 protein entries: ADNP2_HUMAN (see all proteins):ADNP
ADNP2 for paralogs About GeneDecksing
|
Genomic Variants
for ADNP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADNP2 (77866915 - 77905406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADNP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADNP2 |
|
Disorders
/ Diseases
for ADNP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADNP2 for disorders About GeneDecksing
2  diseases for ADNP2: About MalaCardsschizophrenia neuronitis
Export disorders for ADNP2 gene to outside databases
|
Publications
for ADNP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADNP2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ADNP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Activity-dependent neuroprotective protein (ADNP) exp ression level is correlated with the expression of the sister protein ADNP2: de regulation in schizophrenia. (PubMed id 20598862)1 Dresner E....Gozes I. (2011)
- Analysis of the human HP1 interactome reveals novel bi nding partners. (PubMed id 21888893)1 Rosnoblet C....Angrand P.O. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ADNP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADNP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADNP2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ADNP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADNP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADNP2 gene:
Search GeneIP for patents involving ADNP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADNP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADNP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADNP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP2 |
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| |  |  |  |  | | | | |
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 | | | ADNP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP2 |
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