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Aliases for ADNP2 Gene

Aliases for ADNP2 Gene

  • ADNP Homeobox 2 2 3
  • Zinc Finger Protein 508 2 3 4
  • ZNF508 3 4
  • ADNP Homeobox Protein 2 3
  • KIAA0863 4

External Ids for ADNP2 Gene

Previous Symbols for ADNP2 Gene

  • ZNF508

Summaries for ADNP2 Gene

GeneCards Summary for ADNP2 Gene

ADNP2 (ADNP Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ADNP.

UniProtKB/Swiss-Prot for ADNP2 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADNP2 Gene

Genomics for ADNP2 Gene

Genomic Location for ADNP2 Gene

Start:
80,109,031 bp from pter
End:
80,147,523 bp from pter
Size:
38,493 bases
Orientation:
Plus strand

Genomic View for ADNP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADNP2 Gene

Regulatory Elements for ADNP2 Gene

Proteins for ADNP2 Gene

  • Protein details for ADNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ32-ADNP2_HUMAN
    Recommended name:
    ADNP homeobox protein 2
    Protein Accession:
    Q6IQ32
    Secondary Accessions:
    • A8K951
    • O94943
    • Q9H9P3

    Protein attributes for ADNP2 Gene

    Size:
    1131 amino acids
    Molecular mass:
    122833 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74886.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14180.1; Type=Frameshift; Positions=466; Evidence={ECO:0000305};

neXtProt entry for ADNP2 Gene

Proteomics data for ADNP2 Gene at MOPED

Post-translational modifications for ADNP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys872

Other Protein References for ADNP2 Gene

No data available for DME Specific Peptides for ADNP2 Gene

Domains for ADNP2 Gene

Gene Families for ADNP2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

Protein Domains for ADNP2 Gene

Suggested Antigen Peptide Sequences for ADNP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ32

UniProtKB/Swiss-Prot:

ADNP2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q6IQ32
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q6IQ32
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • Q6IQ32
genes like me logo Genes that share domains with ADNP2: view

Function for ADNP2 Gene

Molecular function for ADNP2 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21888893
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADNP2: view

miRNA for ADNP2 Gene

miRTarBase miRNAs that target ADNP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADNP2 Gene

Localization for ADNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADNP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADNP2 Gene COMPARTMENTS Subcellular localization image for ADNP2 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ADNP2: view

Pathways for ADNP2 Gene

SuperPathways for ADNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030182 neuron differentiation ISS --
GO:0030307 positive regulation of cell growth ISS --
GO:0034599 cellular response to oxidative stress ISS --
genes like me logo Genes that share ontologies with ADNP2: view

No data available for Pathways by source for ADNP2 Gene

Transcripts for ADNP2 Gene

Unigene Clusters for ADNP2 Gene

ADNP homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADNP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: -

Relevant External Links for ADNP2 Gene

GeneLoc Exon Structure for
ADNP2
ECgene alternative splicing isoforms for
ADNP2

Expression for ADNP2 Gene

mRNA expression in normal human tissues for ADNP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADNP2 Gene

SOURCE GeneReport for Unigene cluster for ADNP2 Gene Hs.131915

genes like me logo Genes that share expressions with ADNP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADNP2 Gene

Orthologs for ADNP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADNP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADNP2 35
  • 99.64 (n)
  • 99.82 (a)
ADNP2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADNP2 35
  • 84.25 (n)
  • 86.65 (a)
ADNP2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADNP2 35
  • 85.52 (n)
  • 87.61 (a)
ADNP2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adnp2 35
  • 79.79 (n)
  • 80.62 (a)
Adnp2 16
Adnp2 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADNP2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adnp2 35
  • 79.1 (n)
  • 80.77 (a)
chicken
(Gallus gallus)
Aves ADNP2 35
  • 66.76 (n)
  • 62.89 (a)
ADNP2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADNP2 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17180 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adnp2 35
  • 53.3 (n)
  • 46.7 (a)
Str.12157 35
zebrafish
(Danio rerio)
Actinopterygii adnp2a 36
  • 31 (a)
OneToMany
adnp2b 36
  • 33 (a)
OneToMany
Species with no ortholog for ADNP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADNP2 Gene

ENSEMBL:
Gene Tree for ADNP2 (if available)
TreeFam:
Gene Tree for ADNP2 (if available)

Paralogs for ADNP2 Gene

Paralogs for ADNP2 Gene

Selected SIMAP similar genes for ADNP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADNP2: view

Variants for ADNP2 Gene

Sequence variations from dbSNP and Humsavar for ADNP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs588556 -- 80,111,138(+) GAAAC(A/C)GGTAT intron-variant
rs693657 -- 80,116,599(-) caaat(C/T)aaaac intron-variant
rs752793 -- 80,119,205(+) GTGCG(C/T)TTATT intron-variant
rs939232 -- 80,140,435(-) TTTTA(A/G)AAAAT downstream-variant-500B
rs939234 -- 80,120,028(+) taggg(G/T)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADNP2 Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910009 CNV Loss 21882294
dgv3495n71 CNV Gain 21882294
nsv828347 CNV Gain 20364138
esv275287 CNV Gain+Loss 21479260
nsv458317 CNV Gain 19166990

Relevant External Links for ADNP2 Gene

HapMap Linkage Disequilibrium report
ADNP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADNP2 Gene

Disorders for ADNP2 Gene

No disorders were found for ADNP2 Gene.

No data available for UniProtKB/Swiss-Prot for ADNP2 Gene

Publications for ADNP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ADNP2 Gene

Sources for ADNP2 Gene

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