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Aliases for ADNP2 Gene

Aliases for ADNP2 Gene

  • ADNP Homeobox 2 2 3 5
  • Zinc Finger Protein 508 2 3 4
  • ZNF508 3 4
  • KIAA0863 4

External Ids for ADNP2 Gene

Previous HGNC Symbols for ADNP2 Gene

  • ZNF508

Previous GeneCards Identifiers for ADNP2 Gene

  • GC18P075968
  • GC18P077866
  • GC18P074488

Summaries for ADNP2 Gene

GeneCards Summary for ADNP2 Gene

ADNP2 (ADNP Homeobox 2) is a Protein Coding gene. An important paralog of this gene is ADNP.

UniProtKB/Swiss-Prot for ADNP2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADNP2 Gene

Genomics for ADNP2 Gene

Regulatory Elements for ADNP2 Gene

Promoters for ADNP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADNP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADNP2 Gene

80,109,031 bp from pter
80,147,523 bp from pter
38,493 bases
Plus strand

Genomic View for ADNP2 Gene

Genes around ADNP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADNP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADNP2 Gene

Proteins for ADNP2 Gene

  • Protein details for ADNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADNP homeobox protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K951
    • O94943
    • Q9H9P3

    Protein attributes for ADNP2 Gene

    1131 amino acids
    Molecular mass:
    122833 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74886.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14180.1; Type=Frameshift; Positions=466; Evidence={ECO:0000305};

neXtProt entry for ADNP2 Gene

Proteomics data for ADNP2 Gene at MOPED

Post-translational modifications for ADNP2 Gene

  • Ubiquitination at Lys 872
  • Modification sites at PhosphoSitePlus

Other Protein References for ADNP2 Gene

No data available for DME Specific Peptides for ADNP2 Gene

Domains & Families for ADNP2 Gene

Protein Domains for ADNP2 Gene

Suggested Antigen Peptide Sequences for ADNP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ADNP2: view

Function for ADNP2 Gene

Molecular function for ADNP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ADNP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADNP2 Gene

Localization for ADNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADNP2 Gene

Subcellular locations from

Jensen Localization Image for ADNP2 Gene COMPARTMENTS Subcellular localization image for ADNP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ADNP2 Gene

Pathways & Interactions for ADNP2 Gene

SuperPathways for ADNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0071300 cellular response to retinoic acid IEA,ISS --
genes like me logo Genes that share ontologies with ADNP2: view

No data available for Pathways by source and SIGNOR curated interactions for ADNP2 Gene

Drugs & Compounds for ADNP2 Gene

No Compound Related Data Available

Transcripts for ADNP2 Gene

Unigene Clusters for ADNP2 Gene

ADNP homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADNP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP2: - -
SP3: -

Relevant External Links for ADNP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADNP2 Gene

mRNA expression in normal human tissues for ADNP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADNP2 Gene

This gene is overexpressed in Pancreatic juice (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADNP2 Gene

SOURCE GeneReport for Unigene cluster for ADNP2 Gene Hs.131915

genes like me logo Genes that share expression patterns with ADNP2: view

Protein tissue co-expression partners for ADNP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADNP2 Gene

Orthologs for ADNP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADNP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADNP2 35
  • 84.25 (n)
  • 86.65 (a)
ADNP2 36
  • 82 (a)
(Canis familiaris)
Mammalia ADNP2 35
  • 85.52 (n)
  • 87.61 (a)
ADNP2 36
  • 84 (a)
(Mus musculus)
Mammalia Adnp2 35
  • 79.79 (n)
  • 80.62 (a)
Adnp2 16
Adnp2 36
  • 76 (a)
(Pan troglodytes)
Mammalia ADNP2 35
  • 99.64 (n)
  • 99.82 (a)
ADNP2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Adnp2 35
  • 79.1 (n)
  • 80.77 (a)
(Monodelphis domestica)
Mammalia ADNP2 36
  • 70 (a)
(Gallus gallus)
Aves ADNP2 35
  • 66.76 (n)
  • 62.89 (a)
ADNP2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia ADNP2 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adnp2 35
  • 53.3 (n)
  • 46.7 (a)
Str.12157 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17180 35
(Danio rerio)
Actinopterygii adnp2a 36
  • 31 (a)
adnp2b 36
  • 33 (a)
Species with no ortholog for ADNP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADNP2 Gene

Gene Tree for ADNP2 (if available)
Gene Tree for ADNP2 (if available)

Paralogs for ADNP2 Gene

Paralogs for ADNP2 Gene

(1) SIMAP similar genes for ADNP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADNP2: view

Variants for ADNP2 Gene

Sequence variations from dbSNP and Humsavar for ADNP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs588556 -- 80,111,138(+) GAAAC(A/C)GGTAT intron-variant
rs752793 -- 80,119,205(+) GTGCG(C/T)TTATT intron-variant
rs939232 -- 80,140,435(-) TTTTA(A/G)AAAAT downstream-variant-500B
rs939234 -- 80,120,028(+) taggg(G/T)tgggg intron-variant
rs1064058 -- 80,133,156(+) TGGGG(A/C/T)GATGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ADNP2 Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910009 CNV Loss 21882294
dgv3495n71 CNV Gain 21882294
nsv828347 CNV Gain 20364138
esv275287 CNV Gain+Loss 21479260
nsv458317 CNV Gain 19166990

Variation tolerance for ADNP2 Gene

Residual Variation Intolerance Score: 7.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADNP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADNP2 Gene

Disorders for ADNP2 Gene

Relevant External Links for ADNP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADNP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADNP2 Gene

Publications for ADNP2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Autophagy has a key role in the pathophysiology of schizophrenia. (PMID: 24365867) Merenlender-Wagner A. … Gozes I. (Mol. Psychiatry 2013) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: deregulation in schizophrenia. (PMID: 20598862) Dresner E. … Gozes I. (Eur Neuropsychopharmacol 2011) 3
  5. Analysis of the human HP1 interactome reveals novel binding partners. (PMID: 21888893) Rosnoblet C. … Angrand P.O. (Biochem. Biophys. Res. Commun. 2011) 3

Products for ADNP2 Gene

Sources for ADNP2 Gene

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