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Aliases for ADNP2 Gene

Aliases for ADNP2 Gene

  • ADNP Homeobox 2 2 3 5
  • Zinc Finger Protein 508 2 3 4
  • ZNF508 3 4
  • ADNP Homeobox Protein 2 3
  • KIAA0863 4

External Ids for ADNP2 Gene

Previous HGNC Symbols for ADNP2 Gene

  • ZNF508

Previous GeneCards Identifiers for ADNP2 Gene

  • GC18P075968
  • GC18P077866
  • GC18P074488

Summaries for ADNP2 Gene

GeneCards Summary for ADNP2 Gene

ADNP2 (ADNP Homeobox 2) is a Protein Coding gene. An important paralog of this gene is ADNP.

UniProtKB/Swiss-Prot for ADNP2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADNP2 Gene

Genomics for ADNP2 Gene

Regulatory Elements for ADNP2 Gene

Enhancers for ADNP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F079677 1.1 ENCODE 14.3 -429.1 -429132 4.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 CTDP1 ENSG00000266901 ENSG00000266273 ENSG00000265101 ENSG00000266586 ADNP2 RBFA LOC105376875
GH18F079519 1.2 FANTOM5 Ensembl ENCODE 12.1 -585.7 -585655 7.2 HDGF TBL1XR1 SIN3A BMI1 EGR1 ETV6 EGR2 ZNF202 ZNF263 USF2 ADNP2 RBFA NFATC1 ENSG00000267287 HSBP1L1 ATP9B CTDP1 LOC102723506 ENSG00000279981
GH18F080145 0.2 ENCODE 11.7 +36.6 36592 0.2 ZNF600 ADNP2 PARD6G-AS1
GH18F080032 1 ENCODE 11.4 -74.7 -74714 3.1 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 RBFADN TXNL4A RBFA ENSG00000267251 ADNP2 HSBP1L1 PQLC1 ENSG00000267127
GH18F080157 0.6 ENCODE 10.9 +48.9 48902 0.2 CTCF ZNF654 MAFG TRIM22 RAD21 ZNF316 MAFF MBD1 ZNF143 SMC3 RBFA ADNP2 HSBP1L1 ENSG00000278000 PARD6G-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADNP2 on UCSC Golden Path with GeneCards custom track

Promoters for ADNP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528728 669 1801 HDGF PKNOX1 ATF1 CREB3L1 MLX BRCA1 YY1 GLIS2 ZNF207 FOS

Genomic Location for ADNP2 Gene

Chromosome:
18
Start:
80,109,031 bp from pter
End:
80,147,523 bp from pter
Size:
38,493 bases
Orientation:
Plus strand

Genomic View for ADNP2 Gene

Genes around ADNP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADNP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADNP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADNP2 Gene

Proteins for ADNP2 Gene

  • Protein details for ADNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ32-ADNP2_HUMAN
    Recommended name:
    ADNP homeobox protein 2
    Protein Accession:
    Q6IQ32
    Secondary Accessions:
    • A8K951
    • O94943
    • Q9H9P3

    Protein attributes for ADNP2 Gene

    Size:
    1131 amino acids
    Molecular mass:
    122833 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74886.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14180.1; Type=Frameshift; Positions=466; Evidence={ECO:0000305};

neXtProt entry for ADNP2 Gene

Post-translational modifications for ADNP2 Gene

  • Ubiquitination at Lys 872
  • Modification sites at PhosphoSitePlus

Other Protein References for ADNP2 Gene

No data available for DME Specific Peptides for ADNP2 Gene

Domains & Families for ADNP2 Gene

Protein Domains for ADNP2 Gene

Suggested Antigen Peptide Sequences for ADNP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ32

UniProtKB/Swiss-Prot:

ADNP2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ADNP2: view

Function for ADNP2 Gene

Molecular function for ADNP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21888893
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADNP2: view
genes like me logo Genes that share phenotypes with ADNP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADNP2 Gene

Localization for ADNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADNP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADNP2 Gene COMPARTMENTS Subcellular localization image for ADNP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ADNP2: view

Pathways & Interactions for ADNP2 Gene

SuperPathways for ADNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030182 neuron differentiation ISS --
GO:0030307 positive regulation of cell growth ISS --
GO:0034599 cellular response to oxidative stress ISS --
genes like me logo Genes that share ontologies with ADNP2: view

No data available for Pathways by source and SIGNOR curated interactions for ADNP2 Gene

Transcripts for ADNP2 Gene

Unigene Clusters for ADNP2 Gene

ADNP homeobox 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADNP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: -

Relevant External Links for ADNP2 Gene

GeneLoc Exon Structure for
ADNP2
ECgene alternative splicing isoforms for
ADNP2

Expression for ADNP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADNP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADNP2 Gene

This gene is overexpressed in Pancreatic juice (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADNP2 Gene



Protein tissue co-expression partners for ADNP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADNP2 Gene:

ADNP2

SOURCE GeneReport for Unigene cluster for ADNP2 Gene:

Hs.131915
genes like me logo Genes that share expression patterns with ADNP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADNP2 Gene

Orthologs for ADNP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADNP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADNP2 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia ADNP2 34 35
  • 85.52 (n)
cow
(Bos Taurus)
Mammalia ADNP2 34 35
  • 84.25 (n)
mouse
(Mus musculus)
Mammalia Adnp2 34 16 35
  • 79.79 (n)
rat
(Rattus norvegicus)
Mammalia Adnp2 34
  • 79.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ADNP2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADNP2 34 35
  • 66.76 (n)
lizard
(Anolis carolinensis)
Reptilia ADNP2 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adnp2 34
  • 53.3 (n)
Str.12157 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17180 34
zebrafish
(Danio rerio)
Actinopterygii adnp2b 35
  • 33 (a)
OneToMany
adnp2a 35
  • 31 (a)
OneToMany
Species where no ortholog for ADNP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADNP2 Gene

ENSEMBL:
Gene Tree for ADNP2 (if available)
TreeFam:
Gene Tree for ADNP2 (if available)

Paralogs for ADNP2 Gene

Paralogs for ADNP2 Gene

(1) SIMAP similar genes for ADNP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADNP2: view

Variants for ADNP2 Gene

Sequence variations from dbSNP and Humsavar for ADNP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1064058 -- 80,133,156(+) TGGGG(A/T)GATGT reference, synonymous-codon
rs1064059 -- 80,135,800(+) CATGC(A/G)CCTGT reference, synonymous-codon
rs11081591 -- 80,122,919(+) ttacc(A/G)ttgaa intron-variant
rs11081592 -- 80,130,127(+) CTACG(A/G)CCATT intron-variant
rs111257097 -- 80,125,638(+) ACTCC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADNP2 Gene

Variant ID Type Subtype PubMed ID
dgv3413n100 CNV gain 25217958
dgv3414n100 CNV gain 25217958
esv275287 CNV gain+loss 21479260
esv3643326 CNV loss 21293372
esv3643330 CNV loss 21293372
esv3643331 CNV gain 21293372
esv3643332 CNV loss 21293372
esv3643333 CNV gain 21293372
nsv1061450 CNV gain 25217958
nsv1062512 CNV gain 25217958
nsv1065902 CNV gain 25217958
nsv1121958 CNV deletion 24896259
nsv1160552 CNV duplication 26073780
nsv428359 CNV gain 18775914
nsv458317 CNV gain 19166990
nsv577958 CNV gain 21841781
nsv577970 CNV gain 21841781
nsv828347 CNV gain 20364138

Variation tolerance for ADNP2 Gene

Residual Variation Intolerance Score: 7.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADNP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADNP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADNP2 Gene

Disorders for ADNP2 Gene

Relevant External Links for ADNP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADNP2

No disorders were found for ADNP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADNP2 Gene

Publications for ADNP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. (PMID: 25114211) Impens F. … Ribet D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 4 64

Products for ADNP2 Gene

Sources for ADNP2 Gene

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