Aliases for ADNP Gene
External Ids for ADNP Gene
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADNP Gene
ADNP (Activity-Dependent Neuroprotector Homeobox) is a Protein Coding gene. Diseases associated with ADNP include mental retardation, autosomal dominant, 28 and adnp-related multiple congenital anomalies-intellectual disability-autism spectrum disorder. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ADNP2.
UniProtKB/Swiss-Prot for ADNP Gene
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation