Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADNP Gene

protein-coding   GIFtS: 54
GCID: GC20M049505

activity-dependent neuroprotector homeobox

(Previous name: activity-dependent neuroprotector )
 Explore 11 diseases affiliated with
ADNP via our new
 Human Malady Compendium 
Biological research products
for ADNP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Activity-Dependent Neuroprotector Homeobox1 2     Activity-Dependent Neuroprotector1
ADNP11 2 3     Activity-Dependent Neuroprotector Homeobox Protein2
KIAA07841 3     ADNP Homeobox 12
Activity-Dependent Neuroprotective Protein2 3     

External Ids:    HGNC: 157661   Entrez Gene: 233942   Ensembl: ENSG000001011267   OMIM: 6113865   UniProtKB: Q9H2P03   

Export aliases for ADNP gene to outside databases

Previous GC identifers: GC20M049235 GC20M050145 GC20M050192 GC20M048940 GC20M046255


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADNP:
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor
cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal
peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one
homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also
upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell
types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have
been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
involving normal growth and cancer proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADNP gene promoter:
         NF-1   NF-1/L   USF1   AML1a   Roaz   AREB6   Pax-3   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADNP promoter sequence
   Search SABiosciences Chromatin IP Primers for ADNP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

ADNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADNP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M049505:  view genomic region     (about GC identifiers)

Start:
49,505,585 bp from pter      End:
49,547,958 bp from pter
Size:
42,374 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0 (See protein sequence)
Recommended Name: Activity-dependent neuroprotector homeobox protein  
Size: 1102 amino acids; 123563 Da
Subcellular location: Nucleus (Potential)
Miscellaneous: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the
beta-amyloid peptide
Secondary accessions: E1P5Y2 O94881 Q5BKU2 Q9UG34

Explore the universe of human proteins at neXtProt for ADNP: NX_Q9H2P0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2P0

  • ADNP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_056154.1  NP_852107.1  

    ENSEMBL proteins: 
     ENSP00000360662   ENSP00000342905   ENSP00000379346   ENSP00000379349   ENSP00000436181  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): ADNP
    OriGene Custom Protein Services for ADNP 
    GenScript Custom Purified and Recombinant Proteins Services for ADNP
    Novus Biologicals ADNP Protein
    Novus Biologicals ADNP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADNP

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0030424axon ----


    ADNP for ontologies           About GeneDecksing



    ADNP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ADNP
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADNP 
    GenScript Custom Superior Antibodies Services for ADNP
    Novus Biologicals ADNP Antibodies
    Search for Antibodies for ADNP at Abcam  
    Uscn Antibodies for ADNP
    ThermoFisher Antibodies for ADNP

    Assay Products for ADNP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADNP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADNP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADNP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H2P0

    ProtoNet protein and cluster: Q9H2P0

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
    involving normal growth and cancer proliferation

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): ADNP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADNP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidADNP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADNP (see all 7)
    OriGene shRNA RFP: ADNP
    OriGene siRNA: ADNP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADNP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADNP (NM_014913)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADNP
    Search LifeMap BioReagents cell lines for ADNP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005507copper ion binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    ADNP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADNP:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Adnptm1Goz for ADNP
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adnp):
     embryogenesis  mortality/aging  nervous system 

    ADNP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/751 Interacting proteins for ADNP (Q9H2P01, 2, 3 ENSP000003429054) via UniProtKB, MINT, STRING, and/or I2D (see all 751)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144972, 3, ENSP000003204854MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000320485
    MAP1LC3BQ9GZQ82, 3MINT-8259456 I2D: score=2 
    SMARCC2Q8TAQ22, 3, ENSP000002670644MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000267064
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007614short-term memory ----
    GO:0009743response to carbohydrate stimulus ----
    GO:0010035response to inorganic substance ----
    GO:0010629negative regulation of gene expression ----


    ADNP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADNP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADNP
    2 Novoseek chemical compound relationships for ADNP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 24.2 1 18179478 (1)
    zinc 10.2 1 11013255 (1)

    Search CenterWatch for drugs/clinical trials and news about ADNP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADNP gene (2 alternative transcripts): 
    NM_015339.2  NM_181442.1  

    Unigene Cluster for ADNP:

    Activity-dependent neuroprotector homeobox
    Hs.570355  [show with all ESTs]
    Unigene Representative Sequence: BC075794
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371602 ENST00000349014 ENST00000396029(uc002xvt.1) ENST00000396032(uc002xvu.1)
    ENST00000534467

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): ADNP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADNP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidADNP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADNP (see all 7)
    OriGene shRNA RFP: ADNP
    OriGene siRNA: ADNP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADNP (NM_014913)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADNP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADNP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP

    Additional cDNA sequence: 

    AB018327.1 AF250860.1 AK074926.1 AK314734.1 AL080163.1 BC015554.1 BC075794.1 BC090933.1 

    12 DOTS entries:

    DT.120801420  DT.315319  DT.91690998  DT.120801501  DT.100650762  DT.120801408  DT.100796255  DT.75149333 
    DT.100796252  DT.120801503  DT.120801532  DT.97844995 

    24/389 AceView cDNA sequences (see all 389):

    Z39545 CA430506 AW197190 BM702474 BM757379 AL080163 AI859768 AA745620 
    AA062812 AI687188 CA439319 AI692233 BP367213 BE889113 AI142579 BF223855 
    BM678487 AI090971 NM_181442 CB153758 AI679910 BM757329 F01461 CA418550 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADNP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGATTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ADNP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADNP

    SOURCE GeneReport for Unigene cluster: Hs.570355

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain,
    expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of
    expression in colon and breast cancer tissues

        SABiosciences Custom PCR Arrays for ADNP
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADNP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADNP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADNP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adnp1 , 5 activity-dependent neuroprotective protein1, 5 90.12(n)1
    94.45(a)1
      2 (88.41 cM)5
    115381  NM_009628.21  NP_033758.21 
     1681809865 
    chicken
    (Gallus gallus)
    Aves ADNP1 activity-dependent neuroprotector homeobox 80.56(n)
    85.44(a)
      419350  XM_001232400.2  XP_001232401.2 
    lizard
    (Anolis carolinensis)
    Reptilia D3K9H9_ANOCA6
    Activity-dependent neuroprotector Fragment
    81(a)
    1 ↔ 1
    GL343226.1(2085725-2086507)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480314442   -- 72.53(n)    48031444 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi72f042 Transcribed sequence with moderate similarity to protein more 74.63(n)    57069240 


    ENSEMBL Gene Tree for ADNP (if available)
    TreeFam Gene Tree for ADNP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADNP gene
    ADNP22  
    1 SIMAP similar gene for ADNP using alignment to 3 protein entries:     ADNP_HUMAN (see all proteins):
    ADNP2

    ADNP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/898 NCBI SNPs in ADNP are shown (see all 898    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75088231,2
    H--49506397(+) CCTTTC/GCCTTA 2 -- ds5001 trp34Minor allele frequency- G:0.00NS EA 420
    rs1860288571,2
    --49506429(+) GCAAAC/TAGAGG 2 -- ds50010--------
    rs1417881571,2
    --49506431(+) AAATAG/TAGGCA 2 -- ds50010--------
    rs1501594971,2
    --49506460(+) TTGTTA/CCCATC 2 -- ds50010--------
    rs1912451371,2
    --49506482(+) ACGAAC/TGTTTA 2 -- ds50010--------
    rs38346561,2
    C,--49506499(-) TTTTTT/-CTTCT 2 -- ds5001 trp31Minor allele frequency- -:0.00CSA 2
    rs112990781,2
    C--49506572(+) TTACA-/TTTTTT 2 -- ds5001 trp30--------
    rs60961601,2
    H--49506611(+) ATGCAG/AGCTCT 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs60961611,2
    H--49506631(+) CAAAAG/AGTGAA 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs72620891,2
    C--49506691(+) AAAAAC/AAAAAA 2 -- ds5001 trp32Minor allele frequency- A:0.25WA 4

    HapMap Linkage Disequilibrium report for ADNP (49505585 - 49547958 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADNP: --
    Human Gene Mutation Database (HGMD): ADNP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADNP
    DNA2.0 Custom Variant and Variant Library Synthesis for ADNP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADNP for disorders           About GeneDecksing

    OMIM gene information: 611386    OMIM disorders: --

    11 diseases for ADNP:    About MalaCards
    fetal alcohol syndrome    head injury    multiple sclerosis    nephropathy
    parkinson's disease    pheochromocytoma    alcoholism    seizures
    breast cancer    schizophrenia    neuronitis

    1 Novoseek disease relationship for ADNP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11013255 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADNP (1 document)

    Export disorders for ADNP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADNP gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with ADNP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human activity-dependent neuroprotective protein. (PubMed id 11013255)1, 2, 3, 9 Zamostiano R.... Gozes I. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Expression of activity-dependent neuroprotective prot ein in the immune system: possible functions and relevance to multiple sclerosi s. (PubMed id 19923857)1, 9 Braitch M....Constantinescu C.S. (2010)
    7. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PubMed id 17878164)1, 9 Mandel S. and Gozes I. (2007)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's di sease. (PubMed id 22554909)1 Yang M.H....Tyan Y.C. (2012)
    10. Activity-dependent neuroprotective protein modulates i ts own gene expression. (PubMed id 21647709)1 Aboonq M.S....Bubb V.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23394 HGNC: 15766 AceView: ADNP Ensembl:ENSG00000101126 euGenes: HUgn23394
    ECgene: ADNP H-InvDB: ADNP

    (According to HUGE)
    About This Section
    HUGE: KIAA0784

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADNP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADNP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADNP gene:
    Search GeneIP for patents involving ADNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ADNP (ADNP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ADNP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADNP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADNP  
     OriGene Protein Over-expression Lysate for ADNP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ADNP   OriGene 3'-UTR Clone for ADNP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADNP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADNP   OriGene Custom Protein Services for ADNP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADNP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADNP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP
     GenScript Custom Purified and Recombinant Proteins Services for ADNP GenScript cDNA clones with any tag delivered in your preferred vector for ADNP
     GenScript Custom Assay Services for ADNP GenScript Custom Superior Antibodies Services for ADNP
     GenScript Custom overexpressing Cell Line Services for ADNP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADNP promoter
     Search Chromatin IP Primers for ADNP
     RT2 qPCR Primer Assay in human, mouse, rat ADNP
     Search GNC Networks for ADNP
     SABiosciences Custom PCR Arrays for ADNP
     Search Tocris compounds for ADNP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADNP antibodies
     ADNP proteins
     ADNP lysates
     Search for Antibodies for ADNP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ADNP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ADNP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ADNP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP
     SwitchGear 3'UTR luciferase reporter plasmids for ADNP
     SwitchGear Promoter luciferase reporter plasmids for ADNP
     ThermoFisher Antibodies for ADNP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADNP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4