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ADNP Gene

protein-coding GIFtS: 59
GCID: GC20M049505

Activity-Dependent Neuroprotector Homeobox

(Previous name: activity-dependent neuroprotector)

See ADNP-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Activity-Dependent Neuroprotector Homeobox¹ ²		Activity-Dependent Neuroprotector¹
ADNP Homeobox 1¹ ²		Activity-Dependent Neuroprotector Homeobox Protein²
Activity-Dependent Neuroprotective Protein² ³		KIAA0784³
ADNP1² ³

External Ids:	HGNC: 15766¹	Entrez Gene: 23394²	Ensembl: ENSG00000101126⁷	OMIM: 611386⁵	UniProtKB: Q9H2P0³

Export aliases for ADNP gene to outside databases

Previous GC identifers: GC20M049235 GC20M050145 GC20M050192 GC20M048940 GC20M046255

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADNP Gene:

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some

tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive

intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein

contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This

gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability

of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the

same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADNP Gene:

ADNP (activity-dependent neuroprotector homeobox) is a protein-coding gene. Diseases associated with ADNP include mental retardation, autosomal dominant, 28. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ADNP2.

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects

involving normal growth and cancer proliferation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000020.10 NT_011362.11 NC_018931.2

Regulatory elements:

Regulatory transcription factor binding sites in the ADNP gene promoter:
NF-1 NF-1/L USF1 AML1a Roaz AREB6 Pax-3 POU2F1 USF-1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADNP promoter sequence

Search Chromatin IP Primers for ADNP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADNP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.13

ADNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADNP gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M049505: view genomic region (about GC identifiers)

Start:	49,505,585 bp from pter	End:	49,547,958 bp from pter
Size:	42,374 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0 (See protein sequence)

Recommended Name: Activity-dependent neuroprotector homeobox protein

Size: 1102 amino acids; 123563 Da

Miscellaneous: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the

beta-amyloid peptide

Secondary accessions: E1P5Y2 O94881 Q5BKU2 Q9UG34

Explore the universe of human proteins at neXtProt for ADNP: NX_Q9H2P0

Explore proteomics data for ADNP at MOPED

Post-translational modifications:

Ubiquitination² at Lys126, Lys773, Lys777

Modification sites at PhosphoSitePlus

See ADNP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001269460.1 NP_001269461.1 NP_056154.1 NP_852107.1

ENSEMBL proteins:

ENSP00000360662 ENSP00000342905 ENSP00000379346 ENSP00000379349 ENSP00000436181

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	antibodies-online peptides for ADNP

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	antibodies-online kits for ADNP (3 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

ZFHX: Homeoboxes / ZF class

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9H2P0

ProtoNet protein and cluster: Q9H2P0

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Similarity: Contains 9 C2H2-type zinc fingers

Similarity: Contains 1 homeobox DNA-binding domain

Find genes that share domains with ADNP About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADNP_HUMAN, Q9H2P0

Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects

involving normal growth and cancer proliferation

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0043565	sequence-specific DNA binding	IEA	--

Find genes that share ontologies with ADNP About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ADNP:

Upregulation of Wnt/beta-caten

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adnp):

embryogenesis

mortality/aging

nervous system

Find genes that share phenotypes with ADNP About GenesLikeMe

Animal Models:
MGI mouse knock-out Adnp^tm1Goz for ADNP

genOway: Develop your customized and physiologically relevant rodent model for ADNP

miRNA Products:		miRTarBase miRNAs that target ADNP: hsa-let-7b-5p (MIRT052249), hsa-mir-21-5p (MIRT030862), hsa-mir-34a-5p (MIRT025421), hsa-mir-328-3p (MIRT043763), hsa-mir-26b-5p (MIRT029262)

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In Situ Assay
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Flow Cytometry
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

ADNP_HUMAN, Q9H2P0: Nucleus (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytoskeleton	2
cytosol	2
extracellular	2

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with ADNP About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ADNP
Interactions:

Search GeneGlobe Interaction Network for ADNP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for ADNP (Q9H2P0^{1, 2, 3} ENSP00000342905⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 787)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARID1A	O14497²^,³, ENSP00000320485⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000320485
MAP1LC3B	Q9GZQ8²^,³	MINT-8259456 I2D: score=2
SMARCC2	Q8TAQ2²^,³, ENSP00000267064⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000267064
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0043524	negative regulation of neuron apoptotic process	IEA	--

Find genes that share ontologies with ADNP About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ADNP

2 Novoseek inferred chemical compound relationships for ADNP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
h2o2	24.2	1	18179478 (1)
zinc	10.2	1	11013255 (1)

Find genes that share compounds with ADNP About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ADNP gene (5 alternative transcripts):

NM_001282531.1 NM_001282532.1 NM_015339.3 NM_181442.2 XM_006723759.1

Unigene Cluster for ADNP:

Activity-dependent neuroprotector homeobox

Hs.570355 [show with all ESTs]

Unigene Representative Sequence: BC075794

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371602 ENST00000349014 ENST00000396029(uc002xvt.1) ENST00000396032(uc002xvu.1)

ENST00000534467

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		Selected qRT-PCR Assays for microRNAs that regulate ADNP (see all 42):
		hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p

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Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-13751) for ADNP

Additional mRNA sequence:

AB018327.1 AF250860.1 AK074926.1 AK314734.1 AL080163.1 BC015554.1 BC075794.1 BC090933.1

12 DOTS entries:

DT.120801420 DT.315319 DT.91690998 DT.120801501 DT.100650762 DT.120801408 DT.100796255 DT.75149333

DT.100796252 DT.120801503 DT.120801532 DT.97844995

Selected AceView cDNA sequences (see all 389):

BM757379 BF223855 AI679910 F01461 BM666770 AA625972 CA418550 BE898801

AA062812 CA503239 AI523054 BM833774 CA430506 AW510565 Z39545 CD359989

AW614603 BU732902 AW194870 AI687188 AA628575 AI242318 AI417634 AW661912

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADNP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGATTCAT

About this image

ADNP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Pancreas (Endocrine System)
Islets of Langerhans

Testis (Reproductive System)
Leydig Cells Testis Interstitium

ADNP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ADNP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.570355

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain,

expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase

of expression in colon and breast cancer tissues

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADNP gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adnp^{1 , 5}	activity-dependent neuroprotective protein^{1, 5}	90.12(n)¹ 94.45(a)¹		2 (88.41 cM)⁵ 11538¹ NM_009628.2¹ NP_033758.2¹ 168180986⁵
chicken (Gallus gallus)	Aves	ADNP¹	activity-dependent neuroprotector homeobox	80.78(n) 85.79(a)		419350 XM_004947267.1 XP_004947324.1
lizard (Anolis carolinensis)	Reptilia	ADNP⁶	Activity-dependent neuroprotector; Uncharacterized...	19(a)	many ↔ many	GL343226.1(2085725-2086507)
African clawed frog (Xenopus laevis)	Amphibia	48031444²	--	72.53(n)		48031444
zebrafish (Danio rerio)	Actinopterygii	wufi72f04²	Transcribed sequence with moderate similarity to protein more	74.63(n)		57069240

ENSEMBL Gene Tree for ADNP (if available)
TreeFam Gene Tree for ADNP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ADNP gene

ADNP2²

1 SIMAP similar gene for ADNP using alignment to 3 protein entries: ADNP_HUMAN (see all proteins):

ADNP2

Find genes that share paralogs with ADNP About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7508823^1,2	H	--	49506397(+)	`CCTTTC/GCCTTA`	2	--	ds500¹ trp³		4		NS EA	420
rs186028857^1,2		--	49506429(+)	`GCAAAC/TAGAGG`	2	--	ds500¹		0	--	--	--	--
rs141788157^1,2		--	49506431(+)	`AAATAG/TAGGCA`	2	--	ds500¹		0	--	--	--	--
rs150159497^1,2		--	49506460(+)	`TTGTTA/CCCATC`	2	--	ds500¹		0	--	--	--	--
rs191245137^1,2		--	49506482(+)	`ACGAAC/TGTTTA`	2	--	ds500¹		0	--	--	--	--
rs3834656^1,2	C	--	49506501(-)	`TTTTTT/-CTTCT`	2	--	ds500¹ trp³		1		CSA	2
rs11299078^1,2	C	--	49506572(+)	`TTACA-/TTTTTT`	2	--	ds500¹ trp³		0	--	--	--	--
rs6096160^1,2	H	--	49506611(+)	`ATGCAG/AGCTCT`	2	--	ds500¹		4		NS EA	420
rs6096161^1,2	H	--	49506631(+)	`CAAAAG/AGTGAA`	2	--	ds500¹		4		NS EA	420
rs150489825^1,2	C	--	49506669(+)	`CAGTT-/AAAAAAAA`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADNP (49505585 - 49547958 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ADNP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv834002	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): ADNP

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ADNP

DNA2.0 Custom Variant and Variant Library Synthesis for ADNP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 611386 OMIM disorders: --

1 disease for ADNP:
About MalaCards

mental retardation, autosomal dominant, 28

Find genes that share disorders with ADNP About GenesLikeMe

1 Novoseek inferred disease relationship for ADNP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	11013255 (1)

Genetic Association Database (GAD): ADNP
Human Genome Epidemiology (HuGE) Navigator: ADNP (1 document)

Export disorders for ADNP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADNP gene, integrated from 10 sources (see all 55):
(articles sorted by number of sources associating them with ADNP)

Cloning and characterization of the human activity-dependent neuroprotective protein. (PubMed id 11013255)^{1, 2, 3, 9} Zamostiano R.... Gozes I. (J. Biol. Chem. 2001)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 1998)
Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach. (PubMed id 17345061)^{1, 4} KankovA! K....Ott J. (Diabetologia 2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. (PubMed id 19923857)^{1, 9} Braitch M....Constantinescu C.S. (Neuroimmunomodulation 2010)
Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PubMed id 17878164)^{1, 9} Mandel S. and Gozes I. (J. Biol. Chem. 2007)
The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23394	HGNC: 15766	AceView: ADNP	Ensembl:ENSG00000101126	euGenes: HUgn23394
ECgene: ADNP	H-InvDB: ADNP

(According to HUGE)
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HUGE: KIAA0784

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADNP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADNP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADNP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADNP gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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ADNP Gene

Activity-Dependent Neuroprotector Homeobox

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ADNP Gene

Activity-Dependent Neuroprotector Homeobox

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ADNP Human Recombinant Protein Products:

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