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ADNP Gene

protein-coding   GIFtS: 59
GCID: GC20M049505

Activity-Dependent Neuroprotector Homeobox

(Previous name: activity-dependent neuroprotector)
  See ADNP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activity-Dependent Neuroprotector Homeobox1 2     Activity-Dependent Neuroprotector1
ADNP Homeobox 11 2     Activity-Dependent Neuroprotector Homeobox Protein2
Activity-Dependent Neuroprotective Protein2 3     KIAA07843
ADNP12 3     

External Ids:    HGNC: 157661   Entrez Gene: 233942   Ensembl: ENSG000001011267   OMIM: 6113865   UniProtKB: Q9H2P03   

Export aliases for ADNP gene to outside databases

Previous GC identifers: GC20M049235 GC20M050145 GC20M050192 GC20M048940 GC20M046255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADNP Gene:
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some
tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive
intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein
contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This
gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability
of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the
same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADNP Gene:
ADNP (activity-dependent neuroprotector homeobox) is a protein-coding gene. Diseases associated with ADNP include mental retardation, autosomal dominant, 28. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ADNP2.

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
involving normal growth and cancer proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADNP gene promoter:
         NF-1   NF-1/L   USF1   AML1a   Roaz   AREB6   Pax-3   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADNP promoter sequence
   Search Chromatin IP Primers for ADNP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

ADNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADNP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M049505:  view genomic region     (about GC identifiers)

Start:
49,505,585 bp from pter      End:
49,547,958 bp from pter
Size:
42,374 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0 (See protein sequence)
Recommended Name: Activity-dependent neuroprotector homeobox protein  
Size: 1102 amino acids; 123563 Da
Miscellaneous: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the
beta-amyloid peptide
Secondary accessions: E1P5Y2 O94881 Q5BKU2 Q9UG34

Explore the universe of human proteins at neXtProt for ADNP: NX_Q9H2P0

Explore proteomics data for ADNP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys126, Lys773, Lys777
  • Modification sites at PhosphoSitePlus

  • See ADNP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269460.1  NP_001269461.1  NP_056154.1  NP_852107.1  

    ENSEMBL proteins: 
     ENSP00000360662   ENSP00000342905   ENSP00000379346   ENSP00000379349   ENSP00000436181  

    ADNP Human Recombinant Protein Products:

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    Novus Biologicals ADNP Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADNP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H2P0

    ProtoNet protein and cluster: Q9H2P0

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with ADNP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADNP_HUMAN, Q9H2P0
    Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
    involving normal growth and cancer proliferation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ADNP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADNP:
     Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adnp):
     embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with ADNP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adnptm1Goz for ADNP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADNP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADNP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADNP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADNP

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADNP:
    hsa-let-7b-5p (MIRT052249), hsa-mir-21-5p (MIRT030862), hsa-mir-34a-5p (MIRT025421), hsa-mir-328-3p (MIRT043763), hsa-mir-26b-5p (MIRT029262)

    Block miRNA regulation of human, mouse, rat ADNP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidADNP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADNP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ADNP (NM_014913)
    Sino Biological Human cDNA Clone for ADNP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP

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    eBioscience FlowRNA Probe Sets ( VA1-13751) for ADNP 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADNP_HUMAN, Q9H2P0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton2
    cytosol2
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ADNP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADNP
    Interactions:

        Search GeneGlobe Interaction Network for ADNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ADNP (Q9H2P01, 2, 3 ENSP000003429054) via UniProtKB, MINT, STRING, and/or I2D (see all 787)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144972, 3, ENSP000003204854MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000320485
    MAP1LC3BQ9GZQ82, 3MINT-8259456 I2D: score=2 
    SMARCC2Q8TAQ22, 3, ENSP000002670644MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000267064
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0043524negative regulation of neuron apoptotic process IEA--

    Find genes that share ontologies with ADNP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADNP

    2 Novoseek inferred chemical compound relationships for ADNP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 24.2 1 18179478 (1)
    zinc 10.2 1 11013255 (1)



    Find genes that share compounds with ADNP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADNP gene (4 alternative transcripts): 
    NM_001282531.1  NM_001282532.1  NM_015339.3  NM_181442.2  

    Unigene Cluster for ADNP:

    Activity-dependent neuroprotector homeobox
    Hs.570355  [show with all ESTs]
    Unigene Representative Sequence: BC075794
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371602 ENST00000349014 ENST00000396029(uc002xvt.1) ENST00000396032(uc002xvu.1)
    ENST00000534467
    miRNA
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    Block miRNA regulation of human, mouse, rat ADNP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidADNP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADNP
    Predesigned siRNA for gene silencing in human, mouse, rat ADNP
    Clone
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    OriGene ORF clones in mouse, rat for ADNP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADNP (NM_014913)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP
    Primer
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    OriGene qPCR primer pairs and template standards for ADNP
    OriGene qSTAR qPCR primer pairs in human, mouse for ADNP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADNP
      QuantiTect SYBR Green Assays in human, mouse, rat ADNP
      QuantiFast Probe-based Assays in human, mouse, rat ADNP
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    eBioscience FlowRNA Probe Sets ( VA1-13751) for ADNP 

    Additional mRNA sequence: 

    AB018327.1 AF250860.1 AK074926.1 AK314734.1 AL080163.1 BC015554.1 BC075794.1 BC090933.1 

    12 DOTS entries:

    DT.120801420  DT.315319  DT.91690998  DT.120801501  DT.100650762  DT.120801408  DT.100796255  DT.75149333 
    DT.100796252  DT.120801503  DT.120801532  DT.97844995 

    Selected AceView cDNA sequences (see all 389):

    BM757379 BF223855 AI679910 F01461 BM666770 AA625972 CA418550 BE898801 
    AA062812 CA503239 AI523054 BM833774 CA430506 AW510565 Z39545 CD359989 
    AW614603 BU732902 AW194870 AI687188 AA628575 AI242318 AI417634 AW661912 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADNP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGATTCAT
    ADNP Expression
    About this image


    ADNP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ADNP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADNP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570355

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain,
    expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase
    of expression in colon and breast cancer tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADNP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adnp1 , 5 activity-dependent neuroprotective protein1, 5 90.12(n)1
    94.45(a)1
      2 (88.41 cM)5
    115381  NM_009628.21  NP_033758.21 
     1681809865 
    chicken
    (Gallus gallus)
    Aves ADNP1 activity-dependent neuroprotector homeobox 80.78(n)
    85.79(a)
      419350  XM_004947267.1  XP_004947324.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADNP6
    Activity-dependent neuroprotector; Uncharacterized...
    19(a)
    many ↔ many
    GL343226.1(2085725-2086507)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480314442   -- 72.53(n)    48031444 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi72f042 Transcribed sequence with moderate similarity to protein more 74.63(n)    57069240 


    ENSEMBL Gene Tree for ADNP (if available)
    TreeFam Gene Tree for ADNP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADNP gene
    ADNP22  
    1 SIMAP similar gene for ADNP using alignment to 3 protein entries:     ADNP_HUMAN (see all proteins):
    ADNP2

    Find genes that share paralogs with ADNP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADNP (see all 1041)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75088231,2
    H--49506397(+) CCTTTC/GCCTTA 2 -- ds5001 trp34Minor allele frequency- G:0.00NS EA 420
    rs1860288571,2
    --49506429(+) GCAAAC/TAGAGG 2 -- ds50010--------
    rs1417881571,2
    --49506431(+) AAATAG/TAGGCA 2 -- ds50010--------
    rs1501594971,2
    --49506460(+) TTGTTA/CCCATC 2 -- ds50010--------
    rs1912451371,2
    --49506482(+) ACGAAC/TGTTTA 2 -- ds50010--------
    rs38346561,2
    C--49506501(-) TTTTTT/-CTTCT 2 -- ds5001 trp31Minor allele frequency- -:0.00CSA 2
    rs112990781,2
    C--49506572(+) TTACA-/TTTTTT 2 -- ds5001 trp30--------
    rs60961601,2
    H--49506611(+) ATGCAG/AGCTCT 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs60961611,2
    H--49506631(+) CAAAAG/AGTGAA 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1504898251,2
    C--49506669(+) CAGTT-/AAAAAAAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADNP (49505585 - 49547958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADNP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834002CNV Loss17160897

    Human Gene Mutation Database (HGMD): ADNP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADNP
    DNA2.0 Custom Variant and Variant Library Synthesis for ADNP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611386    OMIM disorders: --

    1 disease for ADNP:    
    About MalaCards
    mental retardation, autosomal dominant, 28


    Find genes that share disorders with ADNP           About GenesLikeMe

    1 Novoseek inferred disease relationship for ADNP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11013255 (1)

    Genetic Association Database (GAD): ADNP
    Human Genome Epidemiology (HuGE) Navigator: ADNP (1 document)

    Export disorders for ADNP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADNP gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with ADNP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human activity-dependent neuroprotective protein. (PubMed id 11013255)1, 2, 3, 9 Zamostiano R.... Gozes I. (J. Biol. Chem. 2001)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach. (PubMed id 17345061)1, 4 KankovA! K....Ott J. (Diabetologia 2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. (PubMed id 19923857)1, 9 Braitch M....Constantinescu C.S. (Neuroimmunomodulation 2010)
    8. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PubMed id 17878164)1, 9 Mandel S. and Gozes I. (J. Biol. Chem. 2007)
    9. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23394 HGNC: 15766 AceView: ADNP Ensembl:ENSG00000101126 euGenes: HUgn23394
    ECgene: ADNP H-InvDB: ADNP

    (According to HUGE)
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    HUGE: KIAA0784

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADNP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADNP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADNP gene:
    Search GeneIP for patents involving ADNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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