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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADNP Gene

protein-coding   GIFtS: 58
GCID: GC20M049505

Activity-Dependent Neuroprotector Homeobox

(Previous name: activity-dependent neuroprotector)
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Aliases
for ADNP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Activity-Dependent Neuroprotector Homeobox1 2     Activity-Dependent Neuroprotector1
ADNP Homeobox 11 2     Activity-Dependent Neuroprotector Homeobox Protein2
Activity-Dependent Neuroprotective Protein2 3     KIAA07843
ADNP12 3     

External Ids:    HGNC: 157661   Entrez Gene: 233942   Ensembl: ENSG000001011267   OMIM: 6113865   UniProtKB: Q9H2P03   

Export aliases for ADNP gene to outside databases

Previous GC identifers: GC20M049235 GC20M050145 GC20M050192 GC20M048940 GC20M046255


Summaries
for ADNP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADNP Gene:
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some
tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive
intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein
contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This
gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability
of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the
same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADNP Gene: 
ADNP (activity-dependent neuroprotector homeobox) is a protein-coding gene. Diseases associated with ADNP include head injury, and fetal alcohol syndrome. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ADNP2.

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
involving normal growth and cancer proliferation




Genomic Views
for ADNP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADNP gene promoter:
         NF-1   NF-1/L   USF1   AML1a   Roaz   AREB6   Pax-3   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADNP promoter sequence
   Search SABiosciences Chromatin IP Primers for ADNP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

ADNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADNP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M049505:  view genomic region     (about GC identifiers)

Start:
 49,505,585 bp from pter      End:
 49,547,958 bp from pter
Size:
 42,374 bases      Orientation:
 minus strand

Proteins
for ADNP gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0 (See protein sequence)
Recommended Name: Activity-dependent neuroprotector homeobox protein  
Size: 1102 amino acids; 123563 Da
Subcellular location: Nucleus (Potential)
Miscellaneous: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the
beta-amyloid peptide
Secondary accessions: E1P5Y2 O94881 Q5BKU2 Q9UG34

Explore the universe of human proteins at neXtProt for ADNP: NX_Q9H2P0

Explore proteomics data for ADNP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2P0

    • ADNP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADNP Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269460.1  NP_001269461.1  NP_056154.1  NP_852107.1  

    ENSEMBL proteins: 
     ENSP00000360662   ENSP00000342905   ENSP00000379346   ENSP00000379349   ENSP00000436181  

    Human Recombinant Protein Products for ADNP: 
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    OriGene Protein Over-expression Lysate for ADNP
    OriGene Custom MassSpec 
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    Novus Biologicals ADNP Protein
    Novus Biologicals ADNP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADNP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ADNP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADNP gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ZFHX: Homeoboxes / ZF class

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H2P0

    ProtoNet protein and cluster: Q9H2P0

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    ADNP for domains           About GeneDecksing


    Function
    for ADNP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADNP_HUMAN, Q9H2P0
    Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects
    involving normal growth and cancer proliferation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
         
    ADNP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADNP:
     Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adnp):
     embryogenesis  mortality/aging  nervous system 

    ADNP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adnptm1Goz for ADNP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADNP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADNP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADNP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADNP 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADNP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ADNP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADNP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ADNP

    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of ADNP 
                         Customized lentivirus expression plasmids for stable overexpression of ADNP 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADNP
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP


    Pathways & Interactions
    for ADNP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/788 Interacting proteins for ADNP (Q9H2P01, 2, 3 ENSP000003429054) via UniProtKB, MINT, STRING, and/or I2D (see all 788)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144972, 3, ENSP000003204854MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000320485
    MAP1LC3BQ9GZQ82, 3MINT-8259456 I2D: score=2 
    SMARCC2Q8TAQ22, 3, ENSP000002670644MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000267064
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0043524negative regulation of neuron apoptotic process IEA--

    ADNP for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADNP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADNP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADNP

    2 Novoseek inferred chemical compound relationships for ADNP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 24.2 1 18179478 (1)
    zinc 10.2 1 11013255 (1)

    Search CenterWatch for drugs/clinical trials and news about ADNP

    Transcripts
    for ADNP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADNP gene (4 alternative transcripts): 
    NM_001282531.1  NM_001282532.1  NM_015339.3  NM_181442.2  

    Unigene Cluster for ADNP:

    Activity-dependent neuroprotector homeobox
    Hs.570355  [show with all ESTs]
    Unigene Representative Sequence: BC075794
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371602 ENST00000349014 ENST00000396029(uc002xvt.1) ENST00000396032(uc002xvu.1)
    ENST00000534467

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADNP
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
    hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ADNP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADNP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADNP
    Clone
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    OriGene ORF clones in mouse, rat for ADNP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADNP (NM_014913)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADNP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADNP
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADNP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADNP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADNP

    Additional mRNA sequence: 

    AB018327.1 AF250860.1 AK074926.1 AK314734.1 AL080163.1 BC015554.1 BC075794.1 BC090933.1 

    12 DOTS entries:

    DT.120801420  DT.315319  DT.91690998  DT.120801501  DT.100650762  DT.120801408  DT.100796255  DT.75149333 
    DT.100796252  DT.120801503  DT.120801532  DT.97844995 

    24/389 AceView cDNA sequences (see all 389):

    AA062812 CB243777 CA430506 AA854443 CB306753 AA628575 NM_181442 AI634281 
    AI953820 AI949996 AU279828 CA503239 NM_015339 AA207036 BM772928 BC015554 
    T34137 BM833774 CB152236 AI242318 AI217459 CB153758 AI273694 BF223855 

    GeneLoc Exon Structure


    Expression
    for ADNP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADNP expression in normal human tissues (normalized intensities)      ADNP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGATTCAT
    ADNP Expression
    About this image


    ADNP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See ADNP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADNP

    SOURCE GeneReport for Unigene cluster: Hs.570355

    UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0
    Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain,
    expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase
    of expression in colon and breast cancer tissues

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    In Situ
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    Orthologs
    for ADNP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ADNP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Adnp1 , 5 activity-dependent neuroprotective protein1, 5 90.12(n)1
    94.45(a)1    		   2 (88.41 cM)5
    115381  NM_009628.21  NP_033758.21 
     1681809865 
    chicken
    (Gallus gallus)    		 Aves ADNP1 activity-dependent neuroprotector homeobox 80.56(n)
    85.44(a)    		   419350  XM_001232400.2  XP_001232401.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ADNP6
    		 Activity-dependent neuroprotector; Uncharacterized...
    		 80(a)
    		 1 ↔ 1
    		 GL343226.1(2085725-2086507)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480314442   -- 72.53(n)    48031444 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi72f042 Transcribed sequence with moderate similarity to protein more 74.63(n)    57069240 


    ENSEMBL Gene Tree for ADNP (if available)
    TreeFam Gene Tree for ADNP (if available)

    Paralogs
    for ADNP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADNP gene
    ADNP22  
    1 SIMAP similar gene for ADNP using alignment to 3 protein entries:     ADNP_HUMAN (see all proteins):
    ADNP2

    ADNP for paralogs           About GeneDecksing



    Genomic Variants
    for ADNP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in ADNP are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75088231,2
    		H--49506397(+) CCTTTC/GCCTTA 2 -- ds5001 trp34Minor allele frequency- G:0.00NS EA 420
    rs1860288571,2
    		--49506429(+) GCAAAC/TAGAGG 2 -- ds50010--------
    rs1417881571,2
    		--49506431(+) AAATAG/TAGGCA 2 -- ds50010--------
    rs1501594971,2
    		--49506460(+) TTGTTA/CCCATC 2 -- ds50010--------
    rs1912451371,2
    		--49506482(+) ACGAAC/TGTTTA 2 -- ds50010--------
    rs38346561,2
    		C--49506501(-) TTTTTT/-CTTCT 2 -- ds5001 trp31Minor allele frequency- -:0.00CSA 2
    rs112990781,2
    		C--49506572(+) TTACA-/TTTTTT 2 -- ds5001 trp30--------
    rs60961601,2
    		H--49506611(+) ATGCAG/AGCTCT 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs60961611,2
    		H--49506631(+) CAAAAG/AGTGAA 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1504898251,2
    		C--49506669(+) CAGTT-/AAAAAAAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADNP (49505585 - 49547958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADNP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834002CNV Loss17160897


    Human Gene Mutation Database (HGMD): ADNP
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    Disorders / Diseases
    for ADNP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611386    OMIM disorders: --

    9 diseases for ADNP:    About MalaCards
    head injury    fetal alcohol syndrome    pheochromocytoma    alcoholism
    multiple sclerosis    parkinson's disease    schizophrenia    neuronitis
    breast cancer


    ADNP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for ADNP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11013255 (1)

    Genetic Association Database (GAD): ADNP
    Human Genome Epidemiology (HuGE) Navigator: ADNP (1 document)

    Export disorders for ADNP gene to outside databases

    Publications
    for ADNP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADNP gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with ADNP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human activity-dependent neuroprotective protein. (PubMed id 11013255)1, 2, 3, 9 Zamostiano R.... Gozes I. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach. (PubMed id 17345061)1, 4 Kankova K....Ott J. (2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Expression of activity-dependent neuroprotective prot ein in the immune system: possible functions and relevance to multiple sclerosi s. (PubMed id 19923857)1, 9 Braitch M....Constantinescu C.S. (2010)
    8. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PubMed id 17878164)1, 9 Mandel S. and Gozes I. (2007)
    9. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for ADNP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADNP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23394 HGNC: 15766 AceView: ADNP Ensembl:ENSG00000101126 euGenes: HUgn23394
    ECgene: ADNP H-InvDB: ADNP

    Other Databases showing ADNP gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0784

    Specialized Databases showing ADNP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADNP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADNP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADNP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADNP gene:
    Search GeneIP for patents involving ADNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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