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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADNP Gene

protein-coding GIFtS: 58
GCID: GC20M049505

Activity-Dependent Neuroprotector Homeobox

(Previous name: activity-dependent neuroprotector)

Alzheimer's & Parkinson's Diseases Congress

9 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Activity-Dependent Neuroprotector Homeobox¹ ²		Activity-Dependent Neuroprotector¹
ADNP Homeobox 1¹ ²		Activity-Dependent Neuroprotector Homeobox Protein²
Activity-Dependent Neuroprotective Protein² ³		KIAA0784³
ADNP1² ³

External Ids:	HGNC: 15766¹	Entrez Gene: 23394²	Ensembl: ENSG00000101126⁷	OMIM: 611386⁵	UniProtKB: Q9H2P0³

Export aliases for ADNP gene to outside databases

Previous GC identifers: GC20M049235 GC20M050145 GC20M050192 GC20M048940 GC20M046255

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADNP Gene:

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor

cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal

peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one

homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also

upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell

types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have

been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADNP Gene:

ADNP (activity-dependent neuroprotector homeobox) is a protein-coding gene. Diseases associated with ADNP include head injury, and fetal alcohol syndrome. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ADNP2.

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects

involving normal growth and cancer proliferation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NT_011362.10 NC_018931.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADNP gene promoter:
NF-1 NF-1/L USF1 AML1a Roaz AREB6 Pax-3 POU2F1 USF-1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADNP promoter sequence

Search SABiosciences Chromatin IP Primers for ADNP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADNP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.13

ADNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADNP gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M049505: view genomic region (about GC identifiers)

Start:	49,505,585 bp from pter	End:	49,547,958 bp from pter
Size:	42,374 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0 (See protein sequence)

Recommended Name: Activity-dependent neuroprotector homeobox protein

Size: 1102 amino acids; 123563 Da

Subcellular location: Nucleus (Potential)

Miscellaneous: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the

beta-amyloid peptide

Secondary accessions: E1P5Y2 O94881 Q5BKU2 Q9UG34

Explore the universe of human proteins at neXtProt for ADNP: NX_Q9H2P0

Explore proteomics data for ADNP at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H2P0

ADNP Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001269460.1 NP_001269461.1 NP_056154.1 NP_852107.1

ENSEMBL proteins:

ENSP00000360662 ENSP00000342905 ENSP00000379346 ENSP00000379349 ENSP00000436181

Human Recombinant Protein Products for ADNP:

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	Cloud-Clone Corp. Proteins for ADNP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--

ADNP for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZFHX: Homeoboxes / ZF class

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001356 Homeodomain

IPR009057 Homeodomain-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9H2P0

ProtoNet protein and cluster: Q9H2P0

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Similarity: Contains 9 C2H2-type zinc fingers

Similarity: Contains 1 homeobox DNA-binding domain

ADNP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADNP_HUMAN, Q9H2P0

Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects

involving normal growth and cancer proliferation

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	--	--

ADNP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADNP:

Upregulation of Wnt/beta-caten

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adnp):

embryogenesis

mortality/aging

nervous system

ADNP for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adnp^tm1Goz for ADNP

inGenious Targeting Laboratory - Custom generated mouse model solutions for ADNP

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADNP

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		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
		hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ADNP 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADNP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADNP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/788 Interacting proteins for ADNP (Q9H2P0^{1, 2, 3} ENSP00000342905⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 788)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARID1A	O14497²^,³, ENSP00000320485⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000320485
MAP1LC3B	Q9GZQ8²^,³	MINT-8259456 I2D: score=2
SMARCC2	Q8TAQ2²^,³, ENSP00000267064⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000267064
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0043524	negative regulation of neuron apoptotic process	IEA	--

ADNP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADNP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADNP

2 Novoseek inferred chemical compound relationships for ADNP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
h2o2	24.2	1	18179478 (1)
zinc	10.2	1	11013255 (1)

Search CenterWatch for drugs/clinical trials and news about ADNP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADNP gene (4 alternative transcripts):

NM_001282531.1 NM_001282532.1 NM_015339.3 NM_181442.2

Unigene Cluster for ADNP:

Activity-dependent neuroprotector homeobox

Hs.570355 [show with all ESTs]

Unigene Representative Sequence: BC075794

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371602 ENST00000349014 ENST00000396029(uc002xvt.1) ENST00000396032(uc002xvu.1)

ENST00000534467

miRNA Products:
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		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate ADNP (see all 42):
		hsa-miR-328 hsa-miR-624* hsa-miR-374a hsa-miR-624 hsa-miR-508-3p hsa-miR-374c hsa-miR-23a hsa-miR-556-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ADNP 3' UTR sequence

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Additional mRNA sequence:

AB018327.1 AF250860.1 AK074926.1 AK314734.1 AL080163.1 BC015554.1 BC075794.1 BC090933.1

12 DOTS entries:

DT.120801420 DT.315319 DT.91690998 DT.120801501 DT.100650762 DT.120801408 DT.100796255 DT.75149333

DT.100796252 DT.120801503 DT.120801532 DT.97844995

24/389 AceView cDNA sequences (see all 389):

AA062812 CB243777 CA430506 AA854443 CB306753 AA628575 NM_181442 AI634281

AI953820 AI949996 AU279828 CA503239 NM_015339 AA207036 BM772928 BC015554

T34137 BM833774 CB152236 AI242318 AI217459 CB153758 AI273694 BF223855

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADNP expression in normal human tissues (normalized intensities) ADNP embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGATTCAT

About this image

ADNP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/25 selected tissues (see all 25) fully expand


Reproductive System (Reproductive System) fully expand to see all 7 entries
vagina ; squamous epithelial cells

Skin (Integumentary System) fully expand to see all 5 entries
skin ; keratinocytes

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Tonsil
tonsil ; squamous epithelial cells

See ADNP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADNP

SOURCE GeneReport for Unigene cluster: Hs.570355

UniProtKB/Swiss-Prot: ADNP_HUMAN, Q9H2P0

Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain,

expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of

expression in colon and breast cancer tissues

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADNP gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adnp^{1 , 5}	activity-dependent neuroprotective protein^{1, 5}	90.12(n)¹ 94.45(a)¹		2 (88.41 cM)⁵ 11538¹ NM_009628.2¹ NP_033758.2¹ 168180986⁵
chicken (Gallus gallus)	Aves	ADNP¹	activity-dependent neuroprotector homeobox	80.56(n) 85.44(a)		419350 XM_001232400.2 XP_001232401.2
lizard (Anolis carolinensis)	Reptilia	ADNP⁶	Activity-dependent neuroprotector; Uncharacterized...	80(a)	1 ↔ 1	GL343226.1(2085725-2086507)
African clawed frog (Xenopus laevis)	Amphibia	48031444²	--	72.53(n)		48031444
zebrafish (Danio rerio)	Actinopterygii	wufi72f04²	Transcribed sequence with moderate similarity to protein more	74.63(n)		57069240

ENSEMBL Gene Tree for ADNP (if available)
TreeFam Gene Tree for ADNP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADNP gene

ADNP2²

1 SIMAP similar gene for ADNP using alignment to 3 protein entries: ADNP_HUMAN (see all proteins):

ADNP2

ADNP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7508823^1,2	H	--	49506397(+)	`CCTTTC/GCCTTA`	2	--	ds500¹ trp³		4		NS EA	420
rs186028857^1,2		--	49506429(+)	`GCAAAC/TAGAGG`	2	--	ds500¹		0	--	--	--	--
rs141788157^1,2		--	49506431(+)	`AAATAG/TAGGCA`	2	--	ds500¹		0	--	--	--	--
rs150159497^1,2		--	49506460(+)	`TTGTTA/CCCATC`	2	--	ds500¹		0	--	--	--	--
rs191245137^1,2		--	49506482(+)	`ACGAAC/TGTTTA`	2	--	ds500¹		0	--	--	--	--
rs3834656^1,2	C	--	49506501(-)	`TTTTTT/-CTTCT`	2	--	ds500¹ trp³		1		CSA	2
rs11299078^1,2	C	--	49506572(+)	`TTACA-/TTTTTT`	2	--	ds500¹ trp³		0	--	--	--	--
rs6096160^1,2	H	--	49506611(+)	`ATGCAG/AGCTCT`	2	--	ds500¹		4		NS EA	420
rs6096161^1,2	H	--	49506631(+)	`CAAAAG/AGTGAA`	2	--	ds500¹		4		NS EA	420
rs150489825^1,2	C	--	49506669(+)	`CAGTT-/AAAAAAAA`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADNP (49505585 - 49547958 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ADNP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv834002	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): ADNP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADNP

DNA2.0 Custom Variant and Variant Library Synthesis for ADNP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADNP for disorders           About GeneDecksing

OMIM gene information: 611386    OMIM disorders: --

9 diseases for ADNP:    About MalaCards

head injury fetal alcohol syndrome pheochromocytoma alcoholism

multiple sclerosis parkinson's disease schizophrenia neuronitis

breast cancer

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for ADNP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	11013255 (1)

Genetic Association Database (GAD): ADNP
Human Genome Epidemiology (HuGE) Navigator: ADNP (1 document)

Export disorders for ADNP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADNP gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with ADNP)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of the human activity-dependent neuroprotective protein. (PubMed id 11013255)^{1, 2, 3, 9} Zamostiano R.... Gozes I. (2001)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2, 3} Nagase T.... Ohara O. (1998)
Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach. (PubMed id 17345061)^{1, 4} Kankova K....Ott J. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Expression of activity-dependent neuroprotective prot ein in the immune system: possible functions and relevance to multiple sclerosi s. (PubMed id 19923857)^{1, 9} Braitch M....Constantinescu C.S. (2010)
Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PubMed id 17878164)^{1, 9} Mandel S. and Gozes I. (2007)
The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23394	HGNC: 15766	AceView: ADNP	Ensembl:ENSG00000101126	euGenes: HUgn23394
ECgene: ADNP	H-InvDB: ADNP

(According to HUGE)
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HUGE: KIAA0784

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADNP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADNP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADNP gene
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Patent Information for ADNP gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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