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Aliases for ADM5 Gene

Aliases for ADM5 Gene

  • Adrenomedullin 5 (Putative) 2 3 5
  • Adrenomedullin 5 Homolog (Pig) 2 3
  • C19orf76 3 4
  • Putative Adrenomedullin-5-Like Protein 3
  • Chromosome 19 Open Reading Frame 76 2
  • AM5 3

External Ids for ADM5 Gene

Previous HGNC Symbols for ADM5 Gene

  • C19orf76

Previous GeneCards Identifiers for ADM5 Gene

  • GC19P050197
  • GC19P050198
  • GC19P050205

Summaries for ADM5 Gene

GeneCards Summary for ADM5 Gene

ADM5 (Adrenomedullin 5 (Putative)) is a Protein Coding gene. Diseases associated with ADM5 include Phlebotomus Fever.

UniProtKB/Swiss-Prot for ADM5 Gene

  • Probable non-functional remnant of adrenomedullin-5.

Additional gene information for ADM5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM5 Gene

Genomics for ADM5 Gene

Regulatory Elements for ADM5 Gene

Enhancers for ADM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050678 1.3 Ensembl ENCODE 29.1 +990.8 990813 1 HDGF PKNOX1 ATF1 ZNF133 SIN3A YBX1 GLI4 BRCA1 TCF12 GLIS2 ZNF175 NUP62 POLD1 ENSG00000267808 CPT1C ADM5 ENSG00000268047 PTOV1-AS2 ZNF473 PTOV1
GH19H048751 1.3 ENCODE dbSUPER 20.1 -935.5 -935528 2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZBTB7B ZNF766 ZNF548 SP3 REST PRR12 GRWD1 SNRNP70 RASIP1 SNORD35A ADM5 IZUMO1 NOP53-AS1 RPS9P4 PIH1D1
GH19H050496 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +810.7 810684 6 GLI4 TCF12 GLIS2 GATA2 ZNF202 REST MEF2D GLIS1 NBN NR2C1 PRR12 NUP62 CTU1 NR1H2 ENSG00000268047 RRAS POLD1 ADM5 PTOV1 AKT1S1
GH19H049637 1.8 FANTOM5 ENCODE dbSUPER 11 -48.0 -48011 6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 PRR12 SNRNP70 PIH1D1 SNORD35A ALDH16A1 RPL13A PTOV1-AS2 IRF3 SNORD35B RPS11
GH19H050356 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +669.8 669828 2 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 NAPSB POLD1 NUP62 ENSG00000268047 KCNC3 SNORD35A PTOV1-AS2 PNKP IRF3 SNORD35B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADM5 Gene

Chromosome:
19
Start:
49,688,664 bp from pter
End:
49,690,990 bp from pter
Size:
2,327 bases
Orientation:
Plus strand

Genomic View for ADM5 Gene

Genes around ADM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM5 Gene

Proteins for ADM5 Gene

  • Protein details for ADM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JUS6-ADM5_HUMAN
    Recommended name:
    Putative adrenomedullin-5-like protein
    Protein Accession:
    C9JUS6

    Protein attributes for ADM5 Gene

    Size:
    153 amino acids
    Molecular mass:
    16532 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADM5 Gene

Post-translational modifications for ADM5 Gene

No Post-translational modifications

Other Protein References for ADM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADM5 Gene

Domains & Families for ADM5 Gene

Gene Families for ADM5 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ADM5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ADM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JUS6

UniProtKB/Swiss-Prot:

ADM5_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM5: view

Function for ADM5 Gene

Molecular function for ADM5 Gene

UniProtKB/Swiss-Prot Function:
Probable non-functional remnant of adrenomedullin-5.

Phenotypes From GWAS Catalog for ADM5 Gene

Gene Ontology (GO) - Molecular Function for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ADM5: view

Phenotypes for ADM5 Gene

GenomeRNAi human phenotypes for ADM5:
genes like me logo Genes that share phenotypes with ADM5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADM5 Gene

Localization for ADM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM5 gene
Compartment Confidence
extracellular 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADM5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADM5 Gene

Pathways & Interactions for ADM5 Gene

No Data Available

Interacting Proteins for ADM5 Gene

Gene Ontology (GO) - Biological Process for ADM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ADM5: view

No data available for Pathways by source and SIGNOR curated interactions for ADM5 Gene

Drugs & Compounds for ADM5 Gene

No Compound Related Data Available

Transcripts for ADM5 Gene

mRNA/cDNA for ADM5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(738) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADM5 Gene

Adrenomedullin 5 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADM5 Gene

No ASD Table

Relevant External Links for ADM5 Gene

GeneLoc Exon Structure for
ADM5
ECgene alternative splicing isoforms for
ADM5

Expression for ADM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADM5 Gene:

ADM5

SOURCE GeneReport for Unigene cluster for ADM5 Gene:

Hs.311193
genes like me logo Genes that share expression patterns with ADM5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADM5 Gene

Orthologs for ADM5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM5 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADM5 33
  • 78.87 (n)
dog
(Canis familiaris)
Mammalia ADM5 33 34
  • 76.15 (n)
Species where no ortholog for ADM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADM5 Gene

ENSEMBL:
Gene Tree for ADM5 (if available)
TreeFam:
Gene Tree for ADM5 (if available)

Paralogs for ADM5 Gene

No data available for Paralogs for ADM5 Gene

Variants for ADM5 Gene

Sequence variations from dbSNP and Humsavar for ADM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000163817 -- 49,686,890(+) ATTCC(C/T)GGGTC intron-variant, upstream-variant-2KB
rs1000196752 -- 49,687,133(+) GTGCA(C/T)GGGGT intron-variant, upstream-variant-2KB
rs1000295101 -- 49,688,085(+) ATCGT(C/T)GCATA intron-variant, upstream-variant-2KB
rs1000388855 -- 49,691,481(+) GCATG(A/C)GCAGT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1001301276 -- 49,687,051(+) AGGTG(A/G)CCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADM5 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv7308 OTHER inversion 18451855
nsv817854 CNV gain 17921354
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for ADM5 Gene

Gene Damage Index Score: 1.34; 26.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM5 Gene

Disorders for ADM5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADM5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search ADM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADM5
genes like me logo Genes that share disorders with ADM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM5 Gene

Publications for ADM5 Gene

  1. Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals. (PMID: 18434369) Takei Y … Ueta Y (The Journal of endocrinology 2008) 2 3 4 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ADM5 Gene

Sources for ADM5 Gene

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