Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADM2 Gene

protein-coding GIFtS: 51
GCID: GC22P050920

adrenomedullin 2

Explore 11 diseases affiliated with
ADM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adrenomedullin 2¹ ²
AM2¹ ² ³
FLJ21135¹
DJ579N16.4¹
Intermedin³
Intermedin³

External Ids:	HGNC: 28898¹	Entrez Gene: 79924²	Ensembl: ENSG00000128165⁷	OMIM: 608682⁵	UniProtKB: Q7Z4H4³

ORGUL members:
	NONCODE:n338191

Export aliases for ADM2 gene to outside databases

Previous GC identifers: GC22P049053 GC22P049055 GC22P049210 GC22P049267 GC22P033810

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADM2:

This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in

maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor

activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been

identified. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4

Function: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities

mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway

Gene Wiki entry for ADM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011526.7

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADM2 gene promoter:
ER-alpha Egr-3 Pax-2 Pax-2a RelA E4BP4 LCR-F1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADM2 promoter sequence

Search SABiosciences Chromatin IP Primers for ADM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33

ADM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADM2 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P050920: view genomic region (about GC identifiers)

Start:	50,919,985 bp from pter	End:	50,924,869 bp from pter
Size:	4,885 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4 (See protein sequence)

Recommended Name: ADM2 precursor

Size: 148 amino acids; 15865 Da

Subcellular location: Secreted

Secondary accessions: Q3LFQ0

Explore the universe of human proteins at neXtProt for ADM2: NX_Q7Z4H4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z4H4

ADM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001240774.1 NP_079142.2

ENSEMBL proteins:

ENSP00000379087 ENSP00000379086 ENSP00000354955

Reactome Protein details: Q7Z4H4
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ADM2
	GenScript Custom Purified and Recombinant Proteins Services for ADM2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADM2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

ADM2 for ontologies About GeneDecksing

ADM2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ADM2
	GenScript Custom Superior Antibodies Services for ADM2
	Novus Biologicals ADM2 Antibody
	Search for Antibodies for ADM2 at Abcam
	Uscn Antibodies for ADM2
	Search ThermoFisher Antibodies for ADM2

Assay Products for ADM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADM2 for domains About GeneDecksing

1 InterPro domain/family:

IPR021116 Procalcitonin/adrenomedullin

Graphical View of Domain Structure for InterPro Entry Q7Z4H4

ProtoNet protein and cluster: Q7Z4H4

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4

Similarity: Belongs to the adrenomedullin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4

Function: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities

mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADM2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADM2
		SwitchGear 3'UTR luciferase reporter plasmid: ADM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADM2 (see all 7) OriGene shRNA RFP: ADM2 OriGene siRNA: ADM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADM2 (NM_024866)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADM2
		Search LifeMap BioReagents cell lines for ADM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0032403	protein complex binding	IDA	--

ADM2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Reactome Pathways for ADM2 (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	Calcitonin-like ligand receptors
	GPCR ligand binding

ADM2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for ADM2 (ENSP00000379086⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADM	ENSP00000278175⁴	STRING: ENSP00000278175
CALCA	ENSP00000331746⁴	STRING: ENSP00000331746
CALCB	ENSP00000346017⁴	STRING: ENSP00000346017
CALCR	ENSP00000352561⁴	STRING: ENSP00000352561

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	--
GO:0006468	protein phosphorylation	IDA	--
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA	--
GO:0007586	digestion	IEA	--
GO:0007631	feeding behavior	IEA	--

ADM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADM2

1 HMDB Compound for ADM2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

Search CenterWatch for drugs/clinical trials and news about ADM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADM2 gene (2 alternative transcripts):

NM_001253845.1 NM_024866.5

Unigene Clusters for ADM2:

Adrenomedullin 2

Hs.449099 [show with all ESTs], Hs.743540 [show with all ESTs]

Unigene Representative Sequences: NM_024866, BC012864

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395738(uc003blj.3) ENST00000395737 ENST00000362068(uc011ary.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADM2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ADM2
		SwitchGear 3'UTR luciferase reporter plasmid: ADM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADM2 (see all 7) OriGene shRNA RFP: ADM2 OriGene siRNA: ADM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADM2 (NM_024866)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADM2

Additional cDNA sequence: BC012864.1

6 DOTS entries:

DT.308897 DT.120661663 DT.70105009 DT.439114 DT.100704709 DT.91833961

24/35 AceView cDNA sequences (see all 35):

AK092640 CN481163 NM_024866 AW445022 AB121034 CR456479 AI638686 AK024788

BU584945 AI650897 BX400262 CA430647 AF529213 AA345985 BU630265 AI633839

AK090635 BC012864 AA962212 AA999846 BX348470 AA151693 AA918415 AA316865

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGTTGCG

About this image

ADM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADM2

SOURCE GeneReport for Unigene clusters: Hs.449099 Hs.743540

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4

Tissue specificity: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon,

descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and

pituitary

SABiosciences Custom PCR Arrays for ADM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADM2 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adm2^{1 , 5}	adrenomedullin 2^{1, 5}	73.24(n)¹ 66.2(a)¹		15 (44.81 cM)⁵ 223780¹ NM_182928.3¹ NP_891558.1¹ 89322972⁵
zebrafish (Danio rerio)	Actinopterygii	adm2b⁶ adm2a⁶	adrenomedullin 2a	38(a) 36(a)	many → 1 many → 1	18(5839614-5852323) 4(8940844-8954110)

ENSEMBL Gene Tree for ADM2 (if available)
TreeFam Gene Tree for ADM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78394368^1,2	C,	--	50917986(+)	`AGACCG/ATCCTG`	1	--	us2k¹		1		CSA	2
rs192747881^1,2		--	50918008(+)	`GAAACC/GCTCTC`	1	--	us2k¹		0	--	--	--	--
rs140470328^1,2		--	50918084(+)	`GGCAGA/GAGAAT`	1	--	us2k¹		0	--	--	--	--
rs184491214^1,2		--	50918137(+)	`CGCCAC/TGGCAC`	1	--	us2k¹		0	--	--	--	--
rs138424095^1,2		--	50918164(+)	`CAGTGA/GGACTC`	2	--	us2k¹		0	--	--	--	--
rs58697487^1,2	C	--	50918176(+)	`ATCTC-/AAAAAA`	2	--	us2k¹		2		NA CSA	4
rs142392873^1,2		--	50918300(+)	`CACTCC/TTCGAC`	2	--	us2k¹		0	--	--	--	--
rs9616854^1,2	C,F,A,H,	--	50918406(+)	`CGAACG/AGACGC`	2	--	us2k¹		21		NS EA NA CSA WA	2348
rs190553684^1,2		--	50918455(+)	`GCAGCC/TTGGAA`	2	--	us2k¹		0	--	--	--	--
rs56025031^1,2	C,	--	50918468(+)	`CGTGAC/TACCAA`	2	--	us2k¹		3		WA	122

HapMap Linkage Disequilibrium report for ADM2 (50919985 - 50924869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADM2
1 CNV: 5192

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADM2

DNA2.0 Custom Variant and Variant Library Synthesis for ADM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADM2 for disorders           About GeneDecksing

OMIM gene information: 608682    OMIM disorders: --

11 diseases for ADM2:    About MalaCards

atopic dermatitis dermatitis influenza prostate carcinoma

ischemia hypoxia neuroblastoma prostatitis

adenocarcinoma carcinoma sepsis

Export disorders for ADM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADM2 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with ADM2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. (PubMed id 14706825)^{1, 2, 3, 9} Takei Y.... Miyano S. (2004)
Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. (PubMed id 16359754)^{1, 2, 9} Takahashi K.... Totsune K. (2006)
Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. (PubMed id 14615490)^{1, 2} Roh J.... Hsu S.Y.T. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Expression of adrenomedullin 2 (ADM2)/intermedin (IMD ) in human placenta: role in trophoblast invasion and migration. (PubMed id 19535789)^{1, 9} Chauhan M....Yallampalli C. (2009)
Intermedin (adrenomedullin-2): a potential protective role in human aortic endothelial cells. (PubMed id 19255504)^{1, 9} Pearson L.J....Evans J.J. (2009)
Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems. (PubMed id 17965749)^{1, 9} Bell D. and McDermott B.J. (2008)
Intermedin/adrenomedullin-2 is a hypoxia-induced endo thelial peptide that stabilizes pulmonary microvascular permeability. (PubMed id 19684198)^{1, 9} Pfeil U....Kummer W. (2009)
Intermedin: a skin peptide that is downregulated in atopic dermatitis. (PubMed id 17008878)^{1, 9} Kindt F....Haberberger R.V. (2007)
Intermedin is a new angiogenic growth factor. (PubMed id 19592612)^{1, 9} Smith R.S....Chao J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79924	HGNC: 28898	AceView: ADM2	Ensembl:ENSG00000128165	euGenes: HUgn79924
ECgene: ADM2	H-InvDB: ADM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADM2 gene:
Search GeneIP for patents involving ADM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ADM2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADM2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADM2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ADM2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADM2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADM2		OriGene Custom Protein Services for ADM2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADM2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADM2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADM2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADM2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADM2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADM2

	GenScript Custom Purified and Recombinant Proteins Services for ADM2		GenScript cDNA clones with any tag delivered in your preferred vector for ADM2
	GenScript Custom Assay Services for ADM2		GenScript Custom Superior Antibodies Services for ADM2
	GenScript Custom overexpressing Cell Line Services for ADM2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ADM2 promoter
	Search Chromatin IP Primers for ADM2
	RT² qPCR Primer Assay in human, mouse, rat ADM2
	Search GNC Networks for ADM2
	SABiosciences Custom PCR Arrays for ADM2

Search Tocris compounds for ADM2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADM2 antibodies

	Search for Antibodies for ADM2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ADM2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ADM2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ADM2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM2

	SwitchGear 3'UTR luciferase reporter plasmids for ADM2
	SwitchGear Promoter luciferase reporter plasmids for ADM2

Search ThermoFisher Antibodies for ADM2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADM2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADM2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ADM2 Gene

adrenomedullin 2

Aliases
for ADM2 gene

Summaries
for ADM2 gene

Genomic Views
for ADM2 gene

Proteins
for ADM2 gene

Protein Domains /
Families
for ADM2 gene

Function
for ADM2 gene

Pathways & Interactions
for ADM2 gene

Drugs & Compounds
for ADM2 gene

Transcripts
for ADM2 gene

Expression
for ADM2 gene

Orthologs
for ADM2 gene

Paralogs
for ADM2 gene

Genomic Variants
for ADM2 gene

Disorders / Diseases
for ADM2 gene

Publications
for ADM2 gene

External Searches for ADM2 gene

Genome Databases showing ADM2 gene

Other Databases showing ADM2 gene

Specialized Databases showing ADM2 gene

Intellectual Property
for ADM2 gene

Products
for ADM2 gene

View Random Gene

Advanced Search

Export list of displayed genes

ADM2 Gene

adrenomedullin 2

Aliasesfor ADM2 gene

Summariesfor ADM2 gene

Genomic Viewsfor ADM2 gene

Proteinsfor ADM2 gene

Protein Domains /Familiesfor ADM2 gene

Functionfor ADM2 gene

Pathways & Interactionsfor ADM2 gene

Drugs & Compoundsfor ADM2 gene

Transcriptsfor ADM2 gene

Expression for ADM2 gene

Orthologsfor ADM2 gene

Paralogsfor ADM2 gene

Genomic Variantsfor ADM2 gene

Disorders / Diseasesfor ADM2 gene

Publicationsfor ADM2 gene

External Searches for ADM2 gene

Genome Databases showing ADM2 gene

Other Databases showing ADM2 gene

Specialized Databases showing ADM2 gene

Intellectual Propertyfor ADM2 gene

Productsfor ADM2 gene

View Random Gene

Aliases
for ADM2 gene

Summaries
for ADM2 gene

Genomic Views
for ADM2 gene

Proteins
for ADM2 gene

Protein Domains /
Families
for ADM2 gene

Function
for ADM2 gene

Pathways & Interactions
for ADM2 gene

Drugs & Compounds
for ADM2 gene

Transcripts
for ADM2 gene

Expression
for ADM2 gene

Orthologs
for ADM2 gene

Paralogs
for ADM2 gene

Genomic Variants
for ADM2 gene

Disorders / Diseases
for ADM2 gene

Publications
for ADM2 gene

Intellectual Property
for ADM2 gene

Products
for ADM2 gene