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Aliases for ADM2 Gene

Subcategory (RNA class) for ADM2 Gene

lncRNA

Aliases for ADM2 Gene

  • Adrenomedullin 2 2 3 5
  • Intermedin 3 4
  • AM2 3 4
  • DJ579N16.4 3

External Ids for ADM2 Gene

ORGUL Members for ADM2 Gene

Previous GeneCards Identifiers for ADM2 Gene

  • GC22P049053
  • GC22P049055
  • GC22P049210
  • GC22P049267
  • GC22P050920
  • GC22P033810

Summaries for ADM2 Gene

Entrez Gene Summary for ADM2 Gene

  • This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

GeneCards Summary for ADM2 Gene

ADM2 (Adrenomedullin 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. GO annotations related to this gene include protein complex binding and hormone activity.

UniProtKB/Swiss-Prot for ADM2 Gene

  • IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Gene Wiki entry for ADM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM2 Gene

Genomics for ADM2 Gene

Regulatory Elements for ADM2 Gene

Enhancers for ADM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F050443 0.8 ENCODE 13.4 -36.6 -36594 2.5 KLF1 ZEB1 HIC1 GLIS2 POLR2A PATZ1 SCRT2 ZBTB10 SCRT1 PAF1 PLXNB2 ADM2 SBF1 MIOX MAPK8IP2 CHKB SYCE3 PPP6R2 GC22P050436 GC22P050437
GH22F050481 0.8 ENCODE 0.8 +0.4 427 1.3 DRAP1 KLF1 USF1 SAP130 CEBPG EGR1 POLR2A EZH2 GATAD2A MAZ NCAPH2 LMF2 CHKB MAPK8IP2 ADM2 MIOX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADM2 on UCSC Golden Path with GeneCards custom track

Promoters for ADM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620254 444 1601 DRAP1 KLF1 USF1 SAP130 CEBPG EGR1 POLR2A EZH2 GATAD2A MAZ

Genomic Location for ADM2 Gene

Chromosome:
22
Start:
50,481,556 bp from pter
End:
50,486,440 bp from pter
Size:
4,885 bases
Orientation:
Plus strand

Genomic View for ADM2 Gene

Genes around ADM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM2 Gene

Proteins for ADM2 Gene

  • Protein details for ADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H4-ADM2_HUMAN
    Recommended name:
    ADM2
    Protein Accession:
    Q7Z4H4
    Secondary Accessions:
    • Q3LFQ0

    Protein attributes for ADM2 Gene

    Size:
    148 amino acids
    Molecular mass:
    15865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADM2 Gene

Post-translational modifications for ADM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADM2 Gene

Domains & Families for ADM2 Gene

Gene Families for ADM2 Gene

Protein Domains for ADM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4H4

UniProtKB/Swiss-Prot:

ADM2_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM2: view

Function for ADM2 Gene

Molecular function for ADM2 Gene

UniProtKB/Swiss-Prot Function:
IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Gene Ontology (GO) - Molecular Function for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0032403 protein complex binding IDA 20596610
genes like me logo Genes that share ontologies with ADM2: view
genes like me logo Genes that share phenotypes with ADM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADM2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADM2 Gene

Localization for ADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADM2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with ADM2: view

Pathways & Interactions for ADM2 Gene

genes like me logo Genes that share pathways with ADM2: view

Gene Ontology (GO) - Biological Process for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006468 protein phosphorylation IDA 20596610
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007586 digestion IEA --
GO:0007631 feeding behavior IEA --
genes like me logo Genes that share ontologies with ADM2: view

No data available for SIGNOR curated interactions for ADM2 Gene

Drugs & Compounds for ADM2 Gene

(1) Drugs for ADM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ADM2: view

Transcripts for ADM2 Gene

Unigene Clusters for ADM2 Gene

Adrenomedullin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADM2 Gene

No ASD Table

Relevant External Links for ADM2 Gene

GeneLoc Exon Structure for
ADM2
ECgene alternative splicing isoforms for
ADM2

Expression for ADM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADM2 Gene

mRNA differential expression in normal tissues according to GTEx for ADM2 Gene

This gene is overexpressed in Pancreas (x9.2), Kidney - Cortex (x8.0), and Thyroid (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADM2 Gene:

ADM2

SOURCE GeneReport for Unigene cluster for ADM2 Gene:

Hs.449099

mRNA Expression by UniProt/SwissProt for ADM2 Gene:

Q7Z4H4-ADM2_HUMAN
Tissue specificity: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.
genes like me logo Genes that share expression patterns with ADM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for ADM2 Gene

Orthologs for ADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM2 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia ADM2 34 35
  • 81.46 (n)
dog
(Canis familiaris)
Mammalia ADM2 34 35
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Adm2 34 16 35
  • 75.35 (n)
rat
(Rattus norvegicus)
Mammalia Adm2 34
  • 75.06 (n)
oppossum
(Monodelphis domestica)
Mammalia ADM2 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adm2b 35
  • 39 (a)
OneToMany
adm2a 35
  • 34 (a)
OneToMany
Species where no ortholog for ADM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM2 Gene

ENSEMBL:
Gene Tree for ADM2 (if available)
TreeFam:
Gene Tree for ADM2 (if available)

Paralogs for ADM2 Gene

(1) SIMAP similar genes for ADM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADM2: view

No data available for Paralogs for ADM2 Gene

Variants for ADM2 Gene

Sequence variations from dbSNP and Humsavar for ADM2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111581490 -- 50,483,956(+) GAAAG(G/T)GCTCC upstream-variant-2KB, utr-variant-3-prime
rs112116921 -- 50,482,532(+) GCTGA(A/G)CCATC intron-variant, upstream-variant-2KB
rs112875909 -- 50,481,680(+) TTCGC(G/T)CCCGA upstream-variant-2KB
rs112907082 -- 50,483,168(+) CTAAG(C/T)GCTTC upstream-variant-2KB, utr-variant-3-prime
rs113303006 -- 50,484,360(+) GAGAA(C/G)CACTG nc-transcript-variant, utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ADM2 Gene

Variant ID Type Subtype PubMed ID
nsv955201 CNV deletion 24416366
nsv834239 CNV loss 17160897
nsv834238 CNV loss 17160897
nsv829338 CNV gain 20364138
nsv471224 CNV loss 18288195
nsv3669 CNV insertion 18451855
nsv1160782 CNV deletion 26073780
nsv1057656 CNV gain 25217958

Variation tolerance for ADM2 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM2 Gene

Disorders for ADM2 Gene

Relevant External Links for ADM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADM2

No disorders were found for ADM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADM2 Gene

Publications for ADM2 Gene

  1. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. (PMID: 14706825) Takei Y. … Miyano S. (FEBS Lett. 2004) 2 3 4 22 64
  2. Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. (PMID: 16359754) Takahashi K. … Totsune K. (Peptides 2006) 3 4 22 64
  3. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. (PMID: 19910445) Cai Y. … Qi Y.F. (Cardiovasc. Res. 2010) 3 22 64
  4. Intermedin (adrenomedullin-2): a potential protective role in human aortic endothelial cells. (PMID: 19255504) Pearson L.J. … Evans J.J. (Cell. Physiol. Biochem. 2009) 3 22 64
  5. Expression of adrenomedullin 2 (ADM2)/intermedin (IMD) in human placenta: role in trophoblast invasion and migration. (PMID: 19535789) Chauhan M. … Yallampalli C. (Biol. Reprod. 2009) 3 22 64

Products for ADM2 Gene

Sources for ADM2 Gene

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