Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADM2 Gene

Subcategory (RNA class) for ADM2 Gene


Aliases for ADM2 Gene

  • Adrenomedullin 2 2 3 5
  • Intermedin 3 4
  • AM2 3 4
  • DJ579N16.4 3

External Ids for ADM2 Gene

ORGUL Members for ADM2 Gene

Previous GeneCards Identifiers for ADM2 Gene

  • GC22P049053
  • GC22P049055
  • GC22P049210
  • GC22P049267
  • GC22P050920
  • GC22P033810

Summaries for ADM2 Gene

Entrez Gene Summary for ADM2 Gene

  • This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

GeneCards Summary for ADM2 Gene

ADM2 (Adrenomedullin 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. GO annotations related to this gene include protein complex binding and hormone activity.

UniProtKB/Swiss-Prot for ADM2 Gene

  • IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.

Gene Wiki entry for ADM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM2 Gene

Genomics for ADM2 Gene

Regulatory Elements for ADM2 Gene

Enhancers for ADM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADM2 on UCSC Golden Path with GeneCards custom track

Promoters for ADM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADM2 Gene

50,481,556 bp from pter
50,486,440 bp from pter
4,885 bases
Plus strand

Genomic View for ADM2 Gene

Genes around ADM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM2 Gene

Proteins for ADM2 Gene

  • Protein details for ADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3LFQ0

    Protein attributes for ADM2 Gene

    148 amino acids
    Molecular mass:
    15865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADM2 Gene

Proteomics data for ADM2 Gene at MOPED

Post-translational modifications for ADM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADM2 Gene

Domains & Families for ADM2 Gene

Gene Families for ADM2 Gene

Protein Domains for ADM2 Gene


Suggested Antigen Peptide Sequences for ADM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adrenomedullin family.
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM2: view

Function for ADM2 Gene

Molecular function for ADM2 Gene

UniProtKB/Swiss-Prot Function:
IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
genes like me logo Genes that share phenotypes with ADM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADM2 Gene

Localization for ADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM2 Gene


Subcellular locations from

Jensen Localization Image for ADM2 Gene COMPARTMENTS Subcellular localization image for ADM2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ADM2 Gene

Pathways & Interactions for ADM2 Gene

genes like me logo Genes that share pathways with ADM2: view

Interacting Proteins for ADM2 Gene

Gene Ontology (GO) - Biological Process for ADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006468 protein phosphorylation IDA 20596610
GO:0010628 positive regulation of gene expression IDA 20596610
GO:0045766 positive regulation of angiogenesis IDA 19592612
GO:0045776 negative regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with ADM2: view

No data available for SIGNOR curated interactions for ADM2 Gene

Drugs & Compounds for ADM2 Gene

(1) Drugs for ADM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ADM2: view

Transcripts for ADM2 Gene

mRNA/cDNA for ADM2 Gene

Unigene Clusters for ADM2 Gene

Adrenomedullin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADM2 Gene

No ASD Table

Relevant External Links for ADM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADM2 Gene

mRNA expression in normal human tissues for ADM2 Gene

mRNA differential expression in normal tissues according to GTEx for ADM2 Gene

This gene is overexpressed in Pancreas (x9.2), Kidney - Cortex (x8.0), and Thyroid (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADM2 Gene

SOURCE GeneReport for Unigene cluster for ADM2 Gene Hs.449099

mRNA Expression by UniProt/SwissProt for ADM2 Gene

Tissue specificity: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.
genes like me logo Genes that share expression patterns with ADM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for ADM2 Gene

Orthologs for ADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADM2 35
  • 81.46 (n)
  • 71.13 (a)
ADM2 36
  • 71 (a)
(Canis familiaris)
Mammalia ADM2 35
  • 80.52 (n)
  • 70.42 (a)
ADM2 36
  • 71 (a)
(Mus musculus)
Mammalia Adm2 35
  • 75.35 (n)
  • 66.9 (a)
Adm2 16
Adm2 36
  • 65 (a)
(Pan troglodytes)
Mammalia ADM2 35
  • 99.32 (n)
  • 97.97 (a)
(Rattus norvegicus)
Mammalia Adm2 35
  • 75.06 (n)
  • 66.19 (a)
(Monodelphis domestica)
Mammalia ADM2 36
  • 45 (a)
(Danio rerio)
Actinopterygii adm2a 36
  • 34 (a)
adm2b 36
  • 39 (a)
Species with no ortholog for ADM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM2 Gene

Gene Tree for ADM2 (if available)
Gene Tree for ADM2 (if available)

Paralogs for ADM2 Gene

(1) SIMAP similar genes for ADM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADM2: view

No data available for Paralogs for ADM2 Gene

Variants for ADM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADM2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv914541 CNV Loss 21882294
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv829338 CNV Gain 20364138
nsv914544 CNV Loss 21882294
nsv3669 CNV Insertion 18451855
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897

Variation tolerance for ADM2 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ADM2 Gene

Disorders for ADM2 Gene

Relevant External Links for ADM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADM2 Gene

Publications for ADM2 Gene

  1. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. (PMID: 14706825) Takei Y. … Miyano S. (FEBS Lett. 2004) 2 3 4 23 67
  2. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. (PMID: 19910445) Cai Y. … Qi Y.F. (Cardiovasc. Res. 2010) 3 23
  3. Intermedin (adrenomedullin-2): a potential protective role in human aortic endothelial cells. (PMID: 19255504) Pearson L.J. … Evans J.J. (Cell. Physiol. Biochem. 2009) 3 23
  4. Expression of adrenomedullin 2 (ADM2)/intermedin (IMD) in human placenta: role in trophoblast invasion and migration. (PMID: 19535789) Chauhan M. … Yallampalli C. (Biol. Reprod. 2009) 3 23
  5. Intermedin is a new angiogenic growth factor. (PMID: 19592612) Smith R.S. … Chao J. (Am. J. Physiol. Heart Circ. Physiol. 2009) 3 23

Products for ADM2 Gene

Sources for ADM2 Gene