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ADM2 Gene

protein-coding   GIFtS: 50
GCID: GC22P050920

Adrenomedullin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adrenomedullin 21 2
AM22 3
dJ579N16.42
intermedin2
Intermedin3

External Ids:    HGNC: 288981   Entrez Gene: 799242   Ensembl: ENSG000001281657   OMIM: 6086825   UniProtKB: Q7Z4H43   
ORGUL members:         

Export aliases for ADM2 gene to outside databases

Previous GC identifers: GC22P049053 GC22P049055 GC22P049210 GC22P049267 GC22P033810


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADM2 Gene:
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved
in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like
receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the
same protein, have been identified. (provided by RefSeq, Dec 2011)

GeneCards Summary for ADM2 Gene:
ADM2 (adrenomedullin 2) is a protein-coding gene. Diseases associated with ADM2 include atopic dermatitis, and hypoxia. GO annotations related to this gene include hormone activity and protein complex binding.

UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4
Function: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular
bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway

Gene Wiki entry for ADM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADM2 gene promoter:
         ER-alpha   Egr-3   Pax-2   Pax-2a   RelA   E4BP4   LCR-F1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADM2 promoter sequence
   Search Chromatin IP Primers for ADM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

ADM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADM2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050920:  view genomic region     (about GC identifiers)

Start:
50,919,985 bp from pter      End:
50,924,869 bp from pter
Size:
4,885 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4 (See protein sequence)
Recommended Name: ADM2 precursor  
Size: 148 amino acids; 15865 Da
Secondary accessions: Q3LFQ0

Explore the universe of human proteins at neXtProt for ADM2: NX_Q7Z4H4

Explore proteomics data for ADM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240774.1  NP_079142.2  

    ENSEMBL proteins: 
     ENSP00000379087   ENSP00000379086   ENSP00000354955  
    Reactome Protein details: Q7Z4H4

    ADM2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR021116 Procalcitonin/adrenomedullin

    Graphical View of Domain Structure for InterPro Entry Q7Z4H4

    ProtoNet protein and cluster: Q7Z4H4

    UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4
    Similarity: Belongs to the adrenomedullin family


    ADM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADM2_HUMAN, Q7Z4H4
    Function: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular
    bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0032403protein complex binding IDA--
         
    ADM2 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADM2_HUMAN, Q7Z4H4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    ADM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    4G alpha (s) signalling events
    G alpha (s) signalling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ADM2
        Calcitonin-like ligand receptors
    G alpha (s) signalling events



    ADM2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADM2
    Interactions:

        Search GeneGlobe Interaction Network for ADM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADM2 (ENSP000003790864) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADMENSP000002781754STRING: ENSP00000278175
    CALCAENSP000003317464STRING: ENSP00000331746
    CALCBENSP000003460174STRING: ENSP00000346017
    CALCRENSP000003525614STRING: ENSP00000352561
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0006468protein phosphorylation IDA--
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007586digestion IEA--
    GO:0007631feeding behavior IEA--

    ADM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADM2

    1 HMDB Compound for ADM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADM2 gene (2 alternative transcripts): 
    NM_001253845.1  NM_024866.5  

    Unigene Cluster for ADM2:

    Adrenomedullin 2
    Hs.449099  [show with all ESTs]
    Unigene Representative Sequence: NM_024866
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395738(uc003blj.3) ENST00000395737 ENST00000362068(uc011ary.2)

    miRNA
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    Additional mRNA sequence: 

    AB121034.1 AB236970.1 AF529213.1 AK024788.1 AK090635.1 AK092640.1 AK225097.1 CR456479.1 

    6 DOTS entries:

    DT.308897  DT.120661663  DT.70105009  DT.439114  DT.100704709  DT.91833961 

    Selected AceView cDNA sequences (see all 35):

    AK092640 AW445022 CR456479 CN481163 NM_024866 AB121034 AA345985 AK024788 
    AK090635 BC012864 BU584945 CA430647 AI638686 AI650897 AA999846 AF529213 
    AA962212 AI633839 BX400262 BU630265 BX348470 AA316865 AA151693 AA918415 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGTTGCG
    ADM2 Expression
    About this image

    ADM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449099

    UniProtKB/Swiss-Prot: ADM2_HUMAN, Q7Z4H4
    Tissue specificity: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse
    colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells,
    hypothalamus, and pituitary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADM2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adm21 , 5 adrenomedullin 21, 5 75.35(n)1
    66.9(a)1
      15 (44.81 cM)5
    2237801  NM_182928.41  NP_891558.11 
     893229725 
    zebrafish
    (Danio rerio)
    Actinopterygii adm2b6
    adm2a6
    adrenomedullin 2a
    39(a)
    34(a)
    many → 1
    many → 1
    18(5839614-5852291) ENSDARG00000078875
    4(8940844-8954110) ENSDARG00000045708


    ENSEMBL Gene Tree for ADM2 (if available)
    TreeFam Gene Tree for ADM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADM2 gene
    1 SIMAP similar gene for ADM2 using alignment to 2 protein entries:     ADM2_HUMAN (see all proteins):
    dJ579N16.4

    ADM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADM2 (see all 135)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404703281,2
    --33808531(+) GGCAGA/GAGAAT 1 -- us2k10--------
    rs1844912141,2
    --33808584(+) CGCCAC/TGGCAC 1 -- us2k10--------
    rs783943681,2
    C--50917986(+) AGACCG/ATCCTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1927478811,2
    --50918008(+) GAAACC/GCTCTC 1 -- us2k10--------
    rs1384240951,2
    --50918164(+) CAGTGA/GGACTC 2 -- us2k10--------
    rs586974871,2
    C--50918176(+) ATCTC-/AAAAAA 2 -- us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1423928731,2
    --50918300(+) CACTCC/TTCGAC 2 -- us2k10--------
    rs96168541,2
    C,F,A,H--50918406(+) CGAACG/AGACGC 2 -- us2k121Minor allele frequency- A:0.25NS EA NA CSA WA 2348
    rs1905536841,2
    --50918455(+) GCAGCC/TTGGAA 2 -- us2k10--------
    rs560250311,2
    C,F--50918468(+) CGTGAC/TACCAA 2 -- us2k13Minor allele frequency- T:0.32WA 122

    HapMap Linkage Disequilibrium report for ADM2 (50919985 - 50924869 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADM2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3669CNV Insertion18451855
    nsv914541CNV Loss21882294
    nsv915495CNV Loss21882294
    dgv5065n71CNV Loss21882294
    nsv914544CNV Loss21882294
    dgv5062n71CNV Loss21882294
    nsv834238CNV Loss17160897
    dgv5064n71CNV Loss21882294
    nsv914543CNV Loss21882294
    nsv914525CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608682    OMIM disorders: --

    10 diseases for ADM2:    
    About MalaCards
    atopic dermatitis    hypoxia    dermatitis    sepsis
    influenza    neuroblastoma    endotheliitis    ischemia
    adenocarcinoma    prostatitis


    ADM2 for disorders           About GeneDecksing


    Export disorders for ADM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADM2 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with ADM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. (PubMed id 14706825)1, 2, 3, 9 Takei Y.... Miyano S. (FEBS Lett. 2004)
    2. Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. (PubMed id 16359754)1, 2, 9 Takahashi K.... Totsune K. (Peptides 2006)
    3. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. (PubMed id 14615490)1, 2 Roh J.... Hsu S.Y.T. (J. Biol. Chem. 2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    5. Expression of adrenomedullin 2 (ADM2)/intermedin (IMD) in human placenta: role in trophoblast invasion and migration. (PubMed id 19535789)1, 9 Chauhan M....Yallampalli C. (Biol. Reprod. 2009)
    6. Intermedin (adrenomedullin-2): a potential protective role in human aortic endothelial cells. (PubMed id 19255504)1, 9 Pearson L.J....Evans J.J. (Cell. Physiol. Biochem. 2009)
    7. Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems. (PubMed id 17965749)1, 9 Bell D. and McDermott B.J. (Br. J. Pharmacol. 2008)
    8. Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability. (PubMed id 19684198)1, 9 Pfeil U....Kummer W. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    9. Intermedin: a skin peptide that is downregulated in atopic dermatitis. (PubMed id 17008878)1, 9 Kindt F....Haberberger R.V. (J. Invest. Dermatol. 2007)
    10. Intermedin is a new angiogenic growth factor. (PubMed id 19592612)1, 9 Smith R.S....Chao J. (Am. J. Physiol. Heart Circ. Physiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79924 HGNC: 28898 AceView: ADM2 Ensembl:ENSG00000128165 euGenes: HUgn79924
    ECgene: ADM2 H-InvDB: ADM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADM2 gene:
    Search GeneIP for patents involving ADM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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