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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADM Gene

protein-coding   GIFtS: 64
GCID: GC11P010326

Adrenomedullin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
adrenomedullin1 2
AM2 3
preproadrenomedullin2

External Ids:    HGNC: 2591   Entrez Gene: 1332   Ensembl: ENSG000001489267   OMIM: 1032755   UniProtKB: P353183   

Export aliases for ADM gene to outside databases

Previous GC identifers: GC11P011338 GC11P010896 GC11P010365 GC11P010290 GC11P010283 GC11P009999


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADM Gene:
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1
intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may
function as a hormone in circulation control because it is found in blood in a considerable concentration. The
precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA
was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the
5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator
protein-2 and a cAMP-regulated enhancer element. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADM Gene: 
ADM (adrenomedullin) is a protein-coding gene. Diseases associated with ADM include malignant hypertension, and nephrosclerosis, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include adrenomedullin receptor binding and receptor binding.

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318
Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most
related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and
natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland,
both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in
brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive
effects in blood vessels

Gene Wiki entry for ADM (Adrenomedullin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADM gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADM promoter sequence
   Search SABiosciences Chromatin IP Primers for ADM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ADM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P010326:  view genomic region     (about GC identifiers)

Start:
10,326,227 bp from pter      End:
10,328,944 bp from pter
Size:
2,718 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318 (See protein sequence)
Recommended Name: ADM precursor  
Size: 185 amino acids; 20420 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for ADM:
2FLY (3D)        2L7S (3D)    
Secondary accessions: B2R793 D3DQV3 Q6FGW2

Explore the universe of human proteins at neXtProt for ADM: NX_P35318

Explore proteomics data for ADM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35318

  • ADM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADM Protein Expression
    REFSEQ proteins: NP_001115.1  
    ENSEMBL proteins: 
     ENSP00000278175   ENSP00000431438   ENSP00000436837   ENSP00000433062   ENSP00000436607  
     ENSP00000434354   ENSP00000435124   ENSP00000434749  
    Reactome Protein details: P35318
    Human Recombinant Protein Products for ADM: 
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    Novus Biologicals ADM Protein
    Novus Biologicals ADM Lysate
    Sino Biological Recombinant Protein for ADM
    Sino Biological Cell Lysate for ADM 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADM 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12379507
    GO:0005737cytoplasm IDA12379507

    ADM for ontologies           About GeneDecksing



    ADM Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ADM 
    Cloud-Clone Corp. CLIAs for ADM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR021116 Procalcitonin/adrenomedullin
     IPR001710 Adrenomedullin

    Graphical View of Domain Structure for InterPro Entry P35318

    ProtoNet protein and cluster: P35318

    1 Blocks protein domain: IPB001710 Adrenomedullin signature

    UniProtKB/Swiss-Prot: ADML_HUMAN, P35318
    Similarity: Belongs to the adrenomedullin family


    ADM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADML_HUMAN, P35318
    Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most
    related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and
    natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland,
    both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in
    brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive
    effects in blood vessels

         Genatlas biochemistry entry for ADM:
    adrenomedullin downregulated by cMyc

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8074714
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI--
    GO:0031700adrenomedullin receptor binding IEA--
         
    ADM for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Adm):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 
     other  renal/urinary system  respiratory system 

    ADM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADM: Admtm1Tfjt Admtm1Hku Admtm1.1Mtnz

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADM 

    miRNA
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    hsa-miR-181c hsa-miR-539 hsa-miR-938 hsa-miR-25 hsa-miR-410 hsa-miR-1297 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidADM 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADM About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    Class B/2 (Secretin family receptors)0.36
    G alpha (s) signalling events0.31
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    4Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    5Adrenoceptors
    Sympathetic Nerve Pathway (Neuroeffector Junction)0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ADM
        Myometrial Relaxation and Contraction Pathways
    HIF-1-alpha transcription factor network


    5/7        Reactome Pathways for ADM (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    Calcitonin-like ligand receptors
    GPCR ligand binding

    1 PharmGKB Pathway for ADM
        Sympathetic Nerve Pathway (Neuroeffector Junction)


    ADM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for ADM (P353183 ENSP000002781754) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733, ENSP000003536794I2D: score=2 STRING: ENSP00000353679
    CALCRLQ166023, ENSP000003761774I2D: score=1 STRING: ENSP00000376177
    CFHP086033, ENSP000003563994I2D: score=2 STRING: ENSP00000356399
    EDN1P053053, ENSP000003686834I2D: score=1 STRING: ENSP00000368683
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IDA16964401
    GO:0001666response to hypoxia IEA--
    GO:0001843neural tube closure IEA--
    GO:0002026regulation of the force of heart contraction IEA--
    GO:0002031G-protein coupled receptor internalization IDA10882736

    ADM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADM (ADML)

    1 HMDB Compound for ADM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-1--

    10/110 Novoseek inferred chemical compound relationships for ADM gene (see all 110)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 74.5 6 12183333 (2), 12970090 (1), 19084542 (1), 10988349 (1)
    peptidylglycine 68.3 9 12949839 (2), 15547717 (1), 9514956 (1), 11712085 (1) (see all 5)
    omapatrilat 61.5 14 17343842 (6), 16269971 (4), 11827932 (1)
    nitric oxide 58.2 376 14526432 (10), 17674265 (7), 17902148 (7), 12192890 (6) (see all 99)
    ac 187 57.9 3 10205019 (3)
    ambrisentan 46.2 1 16741057 (1)
    adenylate 44.5 25 11754955 (1), 7673375 (1), 9038592 (1), 10566974 (1) (see all 15)
    cyclic amp 43.4 43 7621913 (3), 9428729 (2), 8728298 (2), 8933372 (2) (see all 21)
    norepinephrine 42.5 67 11459117 (6), 19207415 (3), 9505862 (3), 11410122 (2) (see all 32)
    thiorphan 40.9 5 11488772 (2), 11566914 (2), 8687431 (1)

    1 PharmGKB related drug/compound annotation for ADM gene    About this table
    Drug/compound PharmGKB Annotation
    paroxetineCA  

    Search CenterWatch for drugs/clinical trials and news about ADM / ADML

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADM gene: 
    NM_001124.1  

    Unigene Cluster for ADM:

    Adrenomedullin
    Hs.441047  [show with all ESTs]
    Unigene Representative Sequence: BC015961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278175(uc001mil.1) ENST00000534464 ENST00000530439 ENST00000524948
    ENST00000528655 ENST00000526492 ENST00000525063 ENST00000528544
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ADM (see all 29):
    hsa-miR-181c hsa-miR-539 hsa-miR-938 hsa-miR-25 hsa-miR-410 hsa-miR-1297 hsa-miR-374c hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidADM 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK312893.1 AL359337.1 BC015961.2 BT006902.1 CR541995.1 D14874.1 

    14 DOTS entries:

    DT.100879832  DT.317614  DT.91693814  DT.100879834  DT.100879840  DT.120700642  DT.100879854  DT.100879838 
    DT.100879844  DT.102825578  DT.100696279  DT.100879826  DT.120700593  DT.75142973 

    24/424 AceView cDNA sequences (see all 424):

    CA389815 R05462 CR590237 BX448844 CF126531 CR615821 AU156017 BM695492 
    BU931807 CR619368 BX337536 CR619137 CR615072 CR600917 BX381761 CR594627 
    CR615227 CR621314 CA393580 BM993290 CR612290 BM722262 F08781 CR609222 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADM (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
    SP1:                          -     -                           
    SP2:                          -                                 
    SP3:                          -     -                           
    SP4:                          -     -                           
    SP5:                                                            


    ECgene alternative splicing isoforms for ADM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADM expression in normal human tissues (normalized intensities)      ADM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAGAAAG
    ADM Expression
    About this image


    ADM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Podocytes Podocyte Layer
             Renal Collecting Duct System
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Pericytes Blood Brain Barrier
             Ciliary Ganglion   
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Fibroblast (Uncategorized)
             Human Villous Mesenchymal Fibroblasts (HVMF)   
     
     Intestine
             Human Villous Mesenchymal Fibroblasts (HVMF)   

    See ADM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADM

    SOURCE GeneReport for Unigene cluster: Hs.441047

    UniProtKB/Swiss-Prot: ADML_HUMAN, P35318
    Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle
    and kidney tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADM (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADM gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adm1 , 5 adrenomedullin1, 5 75.29(n)1
    69.54(a)1
      7 (57.70 cM)5
    115351  NM_009627.11  NP_033757.11 
     1106276695 
    chicken
    (Gallus gallus)
    Aves ADM1 adrenomedullin 69.86(n)
    63.01(a)
      423042  XM_420975.3  XP_420975.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.128822 Transcribed sequence with weak similarity to protein more 77.18(n)    BX737005.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ADM (1 of 2)6
    ADM (2 of 2)6
    adrenomedullin
    30(a)
    26(a)
    many → 1
    many → 1
    7(68773102-68774762)
    18(16458927-16459571)


    ENSEMBL Gene Tree for ADM (if available)
    TreeFam Gene Tree for ADM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 SNPs in ADM are shown (see all 102)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38147001,2
    C,F,H--10324658(-) TAACTA/GTTGTT 1 -- us2k17Minor allele frequency- G:0.24EA NS NA 2156
    rs1383934271,2
    C--10324805(+) GCCGCC/GCTGCA 1 -- us2k10--------
    rs1911878091,2
    --10324974(+) TGTCCA/GCTGTT 1 -- us2k10--------
    rs1492609281,2
    --10325186(+) CTTCAC/TACAGC 1 -- us2k10--------
    rs1808906171,2
    --10325259(+) CCGTCA/GAGTCG 1 -- us2k10--------
    rs110427251,2
    C,F,A,H--10325325(+) AAGCAC/AGAAGC 1 -- us2k115Minor allele frequency- A:0.38NA NS WA CSA EA 549
    rs50001,2
    C,F--10325691(+) TCCTTG/TCCTGA 1 -- us2k17Minor allele frequency- T:0.02MN NS WA 388
    rs1396079591,2
    C--10325710(+) TGGCTG/TTGAAG 1 -- us2k10--------
    rs133061101,2
    C,F--10325730(+) GACTGG/AGATGT 1 -- us2k15Minor allele frequency- A:0.01NS 190
    rs1472023471,2
    C--10325787(+) AGTGTA/GCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADM (10326227 - 10328944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483076CNV Complex15286789


    Human Gene Mutation Database (HGMD): ADM
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103275    OMIM disorders: --

    20/145 diseases for ADM (see all 145):    About MalaCards
    malignant hypertension    nephrosclerosis    diabetic retinopathy    adrenomyeloneuropathy
    diabetic angiopathy    choroid plexus carcinoma    macular holes    pheochromocytoma
    functioning pituitary adenoma    cerebral artery occlusion    adenohypophysitis    anaplastic astrocytoma
    non-functioning pituitary adenoma    primary pulmonary hypertension    acute pyelonephritis    oligohydramnios
    adrenocortical carcinoma    rheumatic fever    congestive heart failure    thyrotoxicosis

    4 diseases from the University of Copenhagen DISEASES database for ADM:
    Hypertension     Heart disease     Phaeochromocytoma     Cerebrovascular accident

    ADM for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for ADM gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 83.8 298 15850005 (10), 9487993 (5), 17102095 (5), 9043763 (5) (see all 99)
    heart failure 55.5 199 12630822 (11), 9403555 (9), 11264553 (8), 11401111 (5) (see all 69)
    essential hypertension 50.8 43 11040240 (4), 12228854 (4), 10505213 (3), 9323016 (3) (see all 20)
    hypertension pulmonary 49.4 78 11802959 (6), 9857104 (5), 11083748 (4), 16787197 (4) (see all 26)
    heart failure congestive 49.1 64 9686497 (4), 8550749 (3), 10662746 (2), 9536921 (2) (see all 29)
    shock septic 47 40 10390390 (5), 9201046 (3), 15047974 (2), 12530637 (2) (see all 20)
    cardiac overload 43.6 3 9165059 (2), 20150911 (1)
    cardiovascular diseases 43.4 54 16616959 (3), 11921351 (2), 16583314 (2), 19706311 (2) (see all 36)
    chronic hypotension 43.3 3 10652045 (2)
    hypertension arterial 41.9 17 14718403 (5), 11675821 (2), 15047974 (1), 16490007 (1) (see all 10)

    Genetic Association Database (GAD): ADM
    Human Genome Epidemiology (HuGE) Navigator: ADM (71 documents)

    Export disorders for ADM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADM gene, integrated from 9 sources (see all 1090):
    (articles sorted by number of sources associating them with ADM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PubMed id 7688224)1, 2, 3, 9 Kitamura K.... Eto T. (1993)
    2. Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure. (PubMed id 12753312)1, 4, 9 Ishimitsu T....Matsuoka H. (2003)
    3. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. (PubMed id 8387282)1, 2, 9 Kitamura K.... Eto T. (1993)
    4. Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension. (PubMed id 16097366)1, 4, 9 Kobayashi Y....Soma M. (2005)
    5. Proadrenomedullin-derived peptides. (PubMed id 9578982)1, 2, 9 Samson W.K. (1998)
    6. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (2011)
    7. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    8. A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4years in Chinese. (PubMed id 21075100)1, 4 Ong K.L....Lam K.S. (2011)
    9. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PubMed id 20713499)1, 4 Huang J....Smoller J.W. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 133 HGNC: 259 AceView: ADM Ensembl:ENSG00000148926 euGenes: HUgn133
    ECgene: ADM H-InvDB: ADM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADM Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adm/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADM gene:
    Search GeneIP for patents involving ADM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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