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Aliases for ADM Gene

Aliases for ADM Gene

  • Adrenomedullin 2 3 5
  • AM 3 4
  • Proadrenomedullin N-20 Terminal Peptide 3
  • Preproadrenomedullin 3
  • PAMP 3

External Ids for ADM Gene

Previous GeneCards Identifiers for ADM Gene

  • GC11P011338
  • GC11P010896
  • GC11P010365
  • GC11P010290
  • GC11P010283
  • GC11P009999

Summaries for ADM Gene

Entrez Gene Summary for ADM Gene

  • The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

GeneCards Summary for ADM Gene

ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include Malignant Hypertension and Pulmonary Hypertension. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include receptor binding and adrenomedullin receptor binding.

UniProtKB/Swiss-Prot for ADM Gene

  • AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Wiki entry for ADM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM Gene

Genomics for ADM Gene

Regulatory Elements for ADM Gene

Enhancers for ADM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F010319 1.5 FANTOM5 Ensembl ENCODE 12.7 +20.3 20339 11.6 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS SP5 REST LOC105376544 SBF2 ADM ENSG00000254865 MRVI1 LYVE1 ENSG00000250041 PIR60970 CAND1.11 AMPD3
GH11F010366 1.2 FANTOM5 Ensembl ENCODE 12.4 +62.2 62231 1.7 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 ZNF143 DEK ZNF263 MCM3 ZBED5 ADM CTR9 RPL21P97 AMPD3 LOC105376544 RNU6ATAC33P GC11M010399 PIR60970
GH11F010181 0.6 ENCODE 12.1 -122.7 -122702 0.1 CTCF RFX1 TEAD1 SMC3 RAD21 LOC105376544 AMPD3 ADM SBF2 ENSG00000254865 GC11M010233
GH11F010233 0.9 Ensembl ENCODE 11.9 -70.9 -70923 1.2 GTF2F1 TAF1 JUN BACH1 ZNF384 RAD21 BRCA1 RFX5 GATA2 NFE2 LOC105376544 SBF2 ADM AMPD3 ENSG00000250041 GC11M010233 ENSG00000254865
GH11F010207 1 Ensembl ENCODE 11.9 -96.4 -96403 0.6 CTCF ZNF654 TRIM22 REST RAD21 RFX5 JUND SMC3 TRIM28 MIXL1 LOC105376544 SBF2 ADM AMPD3 ENSG00000254865 GC11M010233
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADM on UCSC Golden Path with GeneCards custom track

Promoters for ADM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000558294 720 6401 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ADM Gene

Chromosome:
11
Start:
10,304,680 bp from pter
End:
10,307,402 bp from pter
Size:
2,723 bases
Orientation:
Plus strand

Genomic View for ADM Gene

Genes around ADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM Gene

Proteins for ADM Gene

  • Protein details for ADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35318-ADML_HUMAN
    Recommended name:
    ADM
    Protein Accession:
    P35318
    Secondary Accessions:
    • B2R793
    • D3DQV3
    • Q6FGW2

    Protein attributes for ADM Gene

    Size:
    185 amino acids
    Molecular mass:
    20420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM Gene

neXtProt entry for ADM Gene

Post-translational modifications for ADM Gene

  • Glycosylation at Thr 54, Thr 66, Tyr 125, Ser 178, and Ser 180
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ADM (Adrenomedullin/ADM)

No data available for DME Specific Peptides for ADM Gene

Domains & Families for ADM Gene

Gene Families for ADM Gene

Protein Domains for ADM Gene

Suggested Antigen Peptide Sequences for ADM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35318

UniProtKB/Swiss-Prot:

ADML_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM: view

Function for ADM Gene

Molecular function for ADM Gene

GENATLAS Biochemistry:
adrenomedullin downregulated by cMyc
UniProtKB/Swiss-Prot Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Ontology (GO) - Molecular Function for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8074714
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 20074556
GO:0031700 adrenomedullin receptor binding IEA --
genes like me logo Genes that share ontologies with ADM: view
genes like me logo Genes that share phenotypes with ADM: view

Animal Models for ADM Gene

MGI Knock Outs for ADM:

Animal Model Products

miRNA for ADM Gene

miRTarBase miRNAs that target ADM

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADM

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADM Gene

Localization for ADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADM Gene COMPARTMENTS Subcellular localization image for ADM gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 10225288
GO:0005737 cytoplasm IDA 12379507
genes like me logo Genes that share ontologies with ADM: view

Pathways & Interactions for ADM Gene

genes like me logo Genes that share pathways with ADM: view

Gene Ontology (GO) - Biological Process for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IDA 16964401
GO:0001666 response to hypoxia IEA --
GO:0001843 neural tube closure IEA --
GO:0001878 NOT response to yeast IDA 10225288
GO:0002026 regulation of the force of heart contraction IEA --
genes like me logo Genes that share ontologies with ADM: view

No data available for SIGNOR curated interactions for ADM Gene

Drugs & Compounds for ADM Gene

(54) Drugs for ADM Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 226
Aldosterone Experimental Pharma Agonist 0
Adrenomedullin (1-12), human Pharma Vasodilator 0

(59) Additional Compounds for ADM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADM Gene

Compound Action Cas Number
Adrenomedullin (1-12), human Vasodilator
genes like me logo Genes that share compounds with ADM: view

Transcripts for ADM Gene

Unigene Clusters for ADM Gene

Adrenomedullin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADM Gene

GeneLoc Exon Structure for
ADM
ECgene alternative splicing isoforms for
ADM

Expression for ADM Gene

mRNA expression in normal human tissues for ADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADM Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ADM Gene

This gene is overexpressed in Adipocyte (51.0) and Peripheral blood mononuclear cells (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADM Gene



Protein tissue co-expression partners for ADM Gene

NURSA nuclear receptor signaling pathways regulating expression of ADM Gene:

ADM

SOURCE GeneReport for Unigene cluster for ADM Gene:

Hs.441047

mRNA Expression by UniProt/SwissProt for ADM Gene:

P35318-ADML_HUMAN
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
genes like me logo Genes that share expression patterns with ADM: view

Primer Products

Orthologs for ADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia ADM 34 35
  • 86.74 (n)
cow
(Bos Taurus)
Mammalia ADM 34
  • 84.29 (n)
bta-mir-6518 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adm 34
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Adm 34 16 35
  • 75.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ADM 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADM 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADM 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adm 34
  • 56.55 (n)
Str.12882 34
zebrafish
(Danio rerio)
Actinopterygii adma 35
  • 28 (a)
OneToOne
Species where no ortholog for ADM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM Gene

ENSEMBL:
Gene Tree for ADM (if available)
TreeFam:
Gene Tree for ADM (if available)

Paralogs for ADM Gene

No data available for Paralogs for ADM Gene

Variants for ADM Gene

Sequence variations from dbSNP and Humsavar for ADM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11042725 -- 10,303,778(+) AAGCA(A/C)GAAGC nc-transcript-variant, upstream-variant-2KB
rs112526486 -- 10,306,461(+) TACCA(A/G)TTCAC upstream-variant-2KB, reference, synonymous-codon
rs1126517 -- 10,306,751(+) CTGCG(A/G)AGACC upstream-variant-2KB, utr-variant-3-prime
rs1126716 -- 10,307,321(+) GAAAC(A/C)CCGAG upstream-variant-2KB, utr-variant-3-prime
rs113773352 -- 10,305,670(+) TTTCT(C/T)CTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADM Gene

Variant ID Type Subtype PubMed ID
nsv483076 CNV gain+loss 15286789

Variation tolerance for ADM Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADM Gene

Human Gene Mutation Database (HGMD)
ADM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM Gene

Disorders for ADM Gene

MalaCards: The human disease database

(20) MalaCards diseases for ADM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant hypertension
  • hypertension malignant
pulmonary hypertension
  • primary pulmonary hypertension
pheochromocytoma
  • pheochromocytoma, modifier of
adrenomyeloneuropathy
  • adrenoleukodystrophy
congestive heart failure
  • cardiac failure congestive
- elite association - COSMIC cancer census association via MalaCards
Search ADM in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADM

Genetic Association Database (GAD)
ADM
Human Genome Epidemiology (HuGE) Navigator
ADM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADM
genes like me logo Genes that share disorders with ADM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM Gene

Publications for ADM Gene

  1. Proadrenomedullin-derived peptides. (PMID: 9578982) Samson W.K. (Front. Neuroendocrinol. 1998) 3 4 22 64
  2. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PMID: 7688224) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 64
  3. A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese. (PMID: 21075100) Ong K.L. … Lam K.S. (Clin. Chim. Acta 2011) 3 46 64
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  5. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) . … Johnson T. (Nature 2011) 3 46 64

Products for ADM Gene

Sources for ADM Gene

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