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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADM Gene

protein-coding GIFtS: 64
GCID: GC11P010326

adrenomedullin

Explore 158 diseases affiliated with
ADM via

MalaCards

our new
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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adrenomedullin¹
AM¹ ² ³
Preproadrenomedullin¹

External Ids:	HGNC: 259¹	Entrez Gene: 133²	Ensembl: ENSG00000148926⁷	OMIM: 103275⁵	UniProtKB: P35318³

Export aliases for ADM gene to outside databases

Previous GC identifers: GC11P011338 GC11P010896 GC11P010365 GC11P010290 GC11P010283 GC11P009999

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADM:

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular

disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in

circulation control because it is found in blood in a considerable concentration. The precursor, called

preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly

expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region

containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a

cAMP-regulated enhancer element. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318

Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related

to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and

both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at

physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland

to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

Gene Wiki entry for ADM (Adrenomedullin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADM gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADM promoter sequence

Search SABiosciences Chromatin IP Primers for ADM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

ADM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADM gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P010326: view genomic region (about GC identifiers)

Start:	10,326,227 bp from pter	End:	10,328,944 bp from pter
Size:	2,718 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318 (See protein sequence)

Recommended Name: ADM precursor

Size: 185 amino acids; 20420 Da

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for ADM:

2FLY (3D)

2L7S (3D)

Secondary accessions: B2R793 D3DQV3 Q6FGW2

Explore the universe of human proteins at neXtProt for ADM: NX_P35318

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35318

ADM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001115.1

ENSEMBL proteins:

ENSP00000278175 ENSP00000431438 ENSP00000436837 ENSP00000433062 ENSP00000436607

ENSP00000434354 ENSP00000435124 ENSP00000434749

Reactome Protein details: P35318
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADM

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	12379507
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	12379507

ADM for ontologies About GeneDecksing

ADM Antibody Products:

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	Uscn ELISAs and CLIAs for ADM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADM for domains About GeneDecksing

2 InterPro domains/families:

IPR021116 Procalcitonin/adrenomedullin

IPR001710 Adrenomedullin

Graphical View of Domain Structure for InterPro Entry P35318

ProtoNet protein and cluster: P35318

1 Blocks protein family: IPB001710 Adrenomedullin signature

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318

Similarity: Belongs to the adrenomedullin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318

Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related

to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and

both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at

physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland

to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

Genatlas biochemistry entry for ADM:

adrenomedullin downregulated by cMyc

miRNA Products:		OriGene 3'-UTR Clone: ADM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADM
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ADM (see all 29):
		hsa-miR-181c hsa-miR-539 hsa-miR-938 hsa-miR-25 hsa-miR-410 hsa-miR-1297 hsa-miR-374c hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: ADM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADM (see all 7) OriGene shRNA RFP: ADM OriGene siRNA: ADM
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ADM (NM_000016)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADM
		Search LifeMap BioReagents cell lines for ADM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	8524787
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0031700	adrenomedullin receptor binding	IEA	--

ADM for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ADM: Adm^tm1Tfjt Adm^tm1Hku Adm^tm1.1Mtnz
     13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Adm):

behavior/neurological	cardiovascular system	cellular	embryogenesis	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle
other	renal/urinary system	respiratory system

ADM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

1.00

HIF-1-alpha transcription factor network

HIF-1-alpha transcription factor network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ADM

	Myometrial Relaxation and Contraction Pathways
	HIF-1-alpha transcription factor network

5/7 Reactome Pathways for ADM (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	Calcitonin-like ligand receptors
	GPCR ligand binding

1 PharmGKB Pathway for ADM

Sympathetic Nerve Pathway (Neuroeffector Junction)

ADM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADM

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/74 Interacting proteins for ADM (P35318³ ENSP00000278175⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MME	P08473³, ENSP00000353679⁴	I2D: score=2 STRING: ENSP00000353679
CALCRL	Q16602³, ENSP00000376177⁴	I2D: score=1 STRING: ENSP00000376177
CFH	P08603³, ENSP00000356399⁴	I2D: score=2 STRING: ENSP00000356399
EDN1	P05305³, ENSP00000368683⁴	I2D: score=1 STRING: ENSP00000368683
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IDA	16964401
GO:0001666	response to hypoxia	IEA	--
GO:0001843	neural tube closure	IEA	--
GO:0002026	regulation of the force of heart contraction	IEA	--
GO:0002031	G-protein coupled receptor internalization	IDA	10882736

ADM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADM

1 HMDB Compound for ADM About this table

Compound	Synonyms	CAS #	PubMed Ids
Aldosterone	(+)-Aldosterone (see all 22)	52-39-1	--

10/110 Novoseek chemical compound relationships for ADM gene (see all 110) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	74.5	6	12183333 (2), 12970090 (1), 19084542 (1), 10988349 (1)
peptidylglycine	68.3	9	12949839 (2), 15547717 (1), 9514956 (1), 11712085 (1) (see all 5)
omapatrilat	61.5	14	17343842 (6), 16269971 (4), 11827932 (1)
nitric oxide	58.2	376	14526432 (10), 17674265 (7), 17902148 (7), 12192890 (6) (see all 99)
ac 187	57.9	3	10205019 (3)
ambrisentan	46.2	1	16741057 (1)
adenylate	44.5	25	11754955 (1), 7673375 (1), 9038592 (1), 10566974 (1) (see all 15)
cyclic amp	43.4	43	7621913 (3), 9428729 (2), 8728298 (2), 8933372 (2) (see all 21)
norepinephrine	42.5	67	11459117 (6), 19207415 (3), 9505862 (3), 11410122 (2) (see all 32)
thiorphan	40.9	5	11488772 (2), 11566914 (2), 8687431 (1)

1 PharmGKB related drug/compound annotation for ADM gene

Drug/compound	PharmGKB Annotation
paroxetine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about ADM / ADML

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADM gene:

NM_001124.1

Unigene Cluster for ADM:

Adrenomedullin

Hs.441047 [show with all ESTs]

Unigene Representative Sequence: BC015961

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000278175(uc001mil.1) ENST00000534464 ENST00000530439 ENST00000524948

ENST00000528655 ENST00000526492 ENST00000525063 ENST00000528544

miRNA Products:		OriGene 3'-UTR Clone: ADM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADM
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ADM (see all 29):
		hsa-miR-181c hsa-miR-539 hsa-miR-938 hsa-miR-25 hsa-miR-410 hsa-miR-1297 hsa-miR-374c hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: ADM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ADM (NM_000016)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADM

Additional cDNA sequence:

AK312893.1 AL359337.1 BC015961.2 BT006902.1 CR541995.1 D14874.1

14 DOTS entries:

DT.100879832 DT.317614 DT.91693814 DT.100879834 DT.100879840 DT.120700642 DT.100879854 DT.100879838

DT.100879844 DT.102825578 DT.100696279 DT.100879826 DT.120700593 DT.75142973

24/424 AceView cDNA sequences (see all 424):

BM695492 CD369396 AL702439 CR620623 CR625658 H24761 CR599806 BG575446

BU740114 BC015961 BX381761 BE408486 CR619368 D82211 BX399259 CF126531

BE814391 CB140420 BM710436 BU931807 R05462 BX378169 CR602691 BX379399

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADM (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	·	4e
SP1:									-		-
SP2:									-
SP3:									-		-
SP4:									-		-
SP5:

ECgene alternative splicing isoforms for ADM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAGAAAG

About this image

ADM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pericytes

Kidney

Heart

Atrioventricular Canal

Heart

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See ADM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADM

SOURCE GeneReport for Unigene cluster: Hs.441047

UniProtKB/Swiss-Prot: ADML_HUMAN, P35318

Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and

kidney tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including ADM (see all 9):

NFKB Signaling Targets in human mouse rat

Multiple Sclerosis in human mouse rat

Cancer PathwayFinder in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADM Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADM gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adm^{1 , 5}	adrenomedullin^{1, 5}	75.29(n)¹ 69.54(a)¹		7 (57.70 cM)⁵ 11535¹ NM_009627.1¹ NP_033757.1¹ 110627669⁵
chicken (Gallus gallus)	Aves	ADM¹	adrenomedullin	69.86(n) 63.01(a)		423042 XM_420975.3 XP_420975.3
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12882²	Transcribed sequence with weak similarity to protein more	77.18(n)		BX737005.1
zebrafish (Danio rerio)	Actinopterygii	BX005395.1⁶ CU571259.1⁶	--	31(a) 31(a)	many → 1 many → 1	18(16458927-16459571) 7(68773102-68774762)

ENSEMBL Gene Tree for ADM (if available)
TreeFam Gene Tree for ADM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3814700^1,2	C,F,H,	--	10324658(-)	`TAACTA/GTTGTT`	1	--	us2k¹		7		EA NS NA	2156
rs138393427^1,2		--	10324805(+)	`GCCGCC/GCTGCA`	1	--	us2k¹		0	--	--	--	--
rs191187809^1,2		--	10324974(+)	`TGTCCA/GCTGTT`	1	--	us2k¹		0	--	--	--	--
rs149260928^1,2		--	10325186(+)	`CTTCAC/TACAGC`	1	--	us2k¹		0	--	--	--	--
rs180890617^1,2		--	10325259(+)	`CCGTCA/GAGTCG`	1	--	us2k¹		0	--	--	--	--
rs11042725^1,2	C,F,A,H,	--	10325325(+)	`AAGCAC/AGAAGC`	1	--	us2k¹		15		NA NS WA CSA EA	549
rs5000^1,2	C,F,	--	10325691(+)	`TCCTTG/TCCTGA`	1	--	us2k¹		7		MN NS WA	388
rs139607959^1,2		--	10325710(+)	`TGGCTG/TTGAAG`	1	--	us2k¹		0	--	--	--	--
rs13306110^1,2	C,	--	10325730(+)	`GACTGG/AGATGT`	1	--	us2k¹		5		NS	190
rs147202347^1,2		--	10325787(+)	`AGTGTA/GCTCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADM (10326227 - 10328944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADM
1 CNV: 0143
Human Gene Mutation Database (HGMD): ADM

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADM for disorders           About GeneDecksing

OMIM gene information: 103275    OMIM disorders: --

20/158 diseases for ADM (see all 158):    About MalaCards

pheochromocytoma macular holes proliferative diabetic retinopathy arterial occlusive disease

peripheral arterial occlusive disease diabetic retinopathy pre-eclampsia myocardial infarction

abdominal aortic aneurysm familial mediterranean fever acute myocardial infarction functioning pituitary adenoma

primary pulmonary hypertension diabetic angiopathy pituitary adenoma vesicoureteral reflux

aortic aneurysm cerebral artery occlusion choroid plexus carcinoma pulmonary hypertension

4 diseases from the University of Copenhagen DISEASES database for ADM:

Hypertension Heart disease Phaeochromocytoma Cerebrovascular accident

10/95 Novoseek disease relationships for ADM gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	83.8	298	15850005 (10), 9487993 (5), 17102095 (5), 9043763 (5) (see all 99)
heart failure	55.5	199	12630822 (11), 9403555 (9), 11264553 (8), 11401111 (5) (see all 69)
essential hypertension	50.8	43	11040240 (4), 12228854 (4), 10505213 (3), 9323016 (3) (see all 20)
hypertension pulmonary	49.4	78	11802959 (6), 9857104 (5), 11083748 (4), 16787197 (4) (see all 26)
heart failure congestive	49.1	64	9686497 (4), 8550749 (3), 10662746 (2), 9536921 (2) (see all 29)
shock septic	47	40	10390390 (5), 9201046 (3), 15047974 (2), 12530637 (2) (see all 20)
cardiac overload	43.6	3	9165059 (2), 20150911 (1)
cardiovascular diseases	43.4	54	16616959 (3), 11921351 (2), 16583314 (2), 19706311 (2) (see all 36)
chronic hypotension	43.3	3	10652045 (2)
hypertension arterial	41.9	17	14718403 (5), 11675821 (2), 15047974 (1), 16490007 (1) (see all 10)

Genetic Association Database (GAD): ADM
Human Genome Epidemiology (HuGE) Navigator: ADM (71 documents)

Export disorders for ADM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADM gene, integrated from 9 sources (see all 1076):
(articles sorted by number of sources associating them with ADM)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PubMed id 7688224)^{1, 2, 3, 9} Kitamura K.... Eto T. (1993)
Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure. (PubMed id 12753312)^{1, 4, 9} Ishimitsu T....Matsuoka H. (2003)
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. (PubMed id 8387282)^{1, 2, 9} Kitamura K.... Eto T. (1993)
Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension. (PubMed id 16097366)^{1, 4, 9} Kobayashi Y....Soma M. (2005)
Proadrenomedullin-derived peptides. (PubMed id 9578982)^{1, 2, 9} Samson W.K. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension. (PubMed id 11463752)^{1, 4} Ishimitsu T....Matsuoka H. (2001)
Structure-activity relationships of adrenomedullin in the circulation and adrenal gland. (PubMed id 10588445)^{1, 2} Champion H.C.... Kadowitz P.J. (1999)
Genomic structure of human adrenomedullin gene. (PubMed id 8074714)^{1, 2} Ishimitsu T.... Matsuo H. (1994)
Decreased synthesis of glomerular adrenomedullin in patients with IgA nephropathy. (PubMed id 15902095)^{1, 9} Kuo M.C....Chen H.C. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 133	HGNC: 259	AceView: ADM	Ensembl:ENSG00000148926	euGenes: HUgn133
ECgene: ADM	H-InvDB: ADM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADM	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADM	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/adm/

Intellectual Property for ADM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADM gene:
Search GeneIP for patents involving ADM

GeneCards and IP:
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