Aliases for ADK Gene
External Ids for ADK Gene
Previous GeneCards Identifiers for ADK Gene
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ADK Gene
ADK (Adenosine Kinase) is a Protein Coding gene. Diseases associated with ADK include hypermethioninemia due to adenosine kinase deficiency and hypermethioninemia encephalopathy due to adenosine kinase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor.
UniProtKB/Swiss-Prot for ADK Gene
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides
Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK acts to decrease intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor and a divalent cation, for example Mg2+, as a co-factor. ADK is regulated by inorganic phosphate levels, the concentration of local free Mg2+ and contains a NXXE motif that is vital for phosphate activation. Inhibition of this enzyme has been implicated in tissue-protective mechanisms against various physiological stresses, including ischemia, seizures, inflammation and pain, thus there is much interest in developing pharmacological ADK inhibitors.