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Aliases for ADIRF Gene

Aliases for ADIRF Gene

  • Adipogenesis Regulatory Factor 2 3 5
  • Adipogenesis Factor Rich In Obesity 2 3 4
  • Adipose Most Abundant Gene Transcript 2 Protein 3 4
  • Adipose-Specific Protein 2 3 4
  • Adipose Specific 2 2 3
  • C10orf116 3 4
  • ApM-2 3 4
  • AFRO 3 4
  • APM2 3 4
  • Adipose Most Abundant Gene Transcript 2 2
  • Chromosome 10 Open Reading Frame 116 2

External Ids for ADIRF Gene

Previous HGNC Symbols for ADIRF Gene

  • C10orf116

Previous GeneCards Identifiers for ADIRF Gene

  • GC10P088728

Summaries for ADIRF Gene

Entrez Gene Summary for ADIRF Gene

  • APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADIRF Gene

ADIRF (Adipogenesis Regulatory Factor) is a Protein Coding gene. Diseases associated with ADIRF include Secondary Hypertrophic Osteoarthropathy.

UniProtKB/Swiss-Prot for ADIRF Gene

  • Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIRF Gene

Genomics for ADIRF Gene

Regulatory Elements for ADIRF Gene

Enhancers for ADIRF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADIRF on UCSC Golden Path with GeneCards custom track

Promoters for ADIRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADIRF on UCSC Golden Path with GeneCards custom track

Genomic Location for ADIRF Gene

Chromosome:
10
Start:
86,968,192 bp from pter
End:
86,983,934 bp from pter
Size:
15,743 bases
Orientation:
Plus strand

Genomic View for ADIRF Gene

Genes around ADIRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIRF Gene

Proteins for ADIRF Gene

  • Protein details for ADIRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15847-ADIRF_HUMAN
    Recommended name:
    Adipogenesis regulatory factor
    Protein Accession:
    Q15847

    Protein attributes for ADIRF Gene

    Size:
    76 amino acids
    Molecular mass:
    7855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIRF Gene

Proteomics data for ADIRF Gene at MOPED

Post-translational modifications for ADIRF Gene

  • Glycosylation at Thr 57
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIRF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADIRF Gene

Domains & Families for ADIRF Gene

Protein Domains for ADIRF Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ADIRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADIRF: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ADIRF Gene

Function for ADIRF Gene

Molecular function for ADIRF Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.
genes like me logo Genes that share phenotypes with ADIRF: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADIRF Gene

Localization for ADIRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIRF Gene

Gene Ontology (GO) - Cellular Components for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ADIRF: view

No data available for Subcellular locations from COMPARTMENTS for ADIRF Gene

Pathways & Interactions for ADIRF Gene

SuperPathways for ADIRF Gene

No Data Available

Interacting Proteins for ADIRF Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361083%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q15847-ADIRF_HUMAN ENSP00000361083 for ADIRF Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IDA 23239344
GO:0072719 cellular response to cisplatin IDA 23239344
GO:2001023 regulation of response to drug IDA 23239344
genes like me logo Genes that share ontologies with ADIRF: view

No data available for Pathways by source and SIGNOR curated interactions for ADIRF Gene

Drugs & Compounds for ADIRF Gene

No Compound Related Data Available

Transcripts for ADIRF Gene

mRNA/cDNA for ADIRF Gene

Unigene Clusters for ADIRF Gene

Adipogenesis regulatory factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADIRF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ADIRF Gene

GeneLoc Exon Structure for
ADIRF
ECgene alternative splicing isoforms for
ADIRF

Expression for ADIRF Gene

mRNA expression in normal human tissues for ADIRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIRF Gene

This gene is overexpressed in Artery - Tibial (x6.5), Artery - Coronary (x4.3), Adipose - Subcutaneous (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for ADIRF Gene

This gene is overexpressed in Nasal epithelium (10.7), Nasopharynx (9.3), Cerebral cortex (9.1), and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADIRF Gene



SOURCE GeneReport for Unigene cluster for ADIRF Gene Hs.642660

mRNA Expression by UniProt/SwissProt for ADIRF Gene

Q15847-ADIRF_HUMAN
Tissue specificity: Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.
genes like me logo Genes that share expression patterns with ADIRF: view

Primer Products

No data available for Protein tissue co-expression partners for ADIRF Gene

Orthologs for ADIRF Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIRF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C28H10orf116 35
  • 88.16 (n)
  • 85.53 (a)
C28H10ORF116 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H10orf116 35
  • 86.94 (n)
  • 83.78 (a)
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf116 35
  • 98.81 (n)
  • 98.21 (a)
C10ORF116 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIRF 36
  • 66 (a)
OneToOne
Species with no ortholog for ADIRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIRF Gene

ENSEMBL:
Gene Tree for ADIRF (if available)
TreeFam:
Gene Tree for ADIRF (if available)

Paralogs for ADIRF Gene

No data available for Paralogs for ADIRF Gene

Variants for ADIRF Gene

Variation tolerance for ADIRF Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADIRF Gene

Disorders for ADIRF Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADIRF Gene - From: DISEASES

Disorder Aliases PubMed IDs
secondary hypertrophic osteoarthropathy
  • bamberger-marie disease
- elite association - COSMIC cancer census association via MalaCards
Search ADIRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADIRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIRF
genes like me logo Genes that share disorders with ADIRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIRF Gene

Publications for ADIRF Gene

  1. A Novel pro-adipogenesis factor abundant in adipose tissues and over- expressed in obesity acts upstream of PPARgamma and C/EBPalpha. (PMID: 23239344) Ni Y. … Guo X. (J. Bioenerg. Biomembr. 2013) 2 3 4 67
  2. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). (PMID: 8619847) Maeda K. … Matsubara K. (Biochem. Biophys. Res. Commun. 1996) 2 3
  3. Overexpression of C10orf116 promotes proliferation, inhibits apoptosis and enhances glucose transport in 3T3-L1 adipocytes. (PMID: 23467766) Chen L. … Guo X.R. (Mol Med Rep 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ADIRF Gene

Sources for ADIRF Gene

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