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Aliases for ADIRF Gene

Aliases for ADIRF Gene

  • Adipogenesis Regulatory Factor 2 3 5
  • Adipogenesis Factor Rich In Obesity 2 3 4
  • Adipose Most Abundant Gene Transcript 2 Protein 3 4
  • Adipose-Specific Protein 2 3 4
  • Adipose Specific 2 2 3
  • C10orf116 3 4
  • ApM-2 3 4
  • AFRO 3 4
  • APM2 3 4
  • Adipose Most Abundant Gene Transcript 2 2
  • Chromosome 10 Open Reading Frame 116 2

External Ids for ADIRF Gene

Previous HGNC Symbols for ADIRF Gene

  • C10orf116

Previous GeneCards Identifiers for ADIRF Gene

  • GC10P088728

Summaries for ADIRF Gene

Entrez Gene Summary for ADIRF Gene

  • APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADIRF Gene

ADIRF (Adipogenesis Regulatory Factor) is a Protein Coding gene. Diseases associated with ADIRF include Obesity and Secondary Hypertrophic Osteoarthropathy.

UniProtKB/Swiss-Prot for ADIRF Gene

  • Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIRF Gene

Genomics for ADIRF Gene

Regulatory Elements for ADIRF Gene

Enhancers for ADIRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ADIRF on UCSC Golden Path with GeneCards custom track

Promoters for ADIRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ADIRF Gene

Chromosome:
10
Start:
86,968,192 bp from pter
End:
86,983,934 bp from pter
Size:
15,743 bases
Orientation:
Plus strand

Genomic View for ADIRF Gene

Genes around ADIRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIRF Gene

Proteins for ADIRF Gene

  • Protein details for ADIRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15847-ADIRF_HUMAN
    Recommended name:
    Adipogenesis regulatory factor
    Protein Accession:
    Q15847

    Protein attributes for ADIRF Gene

    Size:
    76 amino acids
    Molecular mass:
    7855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIRF Gene

Post-translational modifications for ADIRF Gene

  • Glycosylation at Thr 57
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIRF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADIRF Gene

Domains & Families for ADIRF Gene

Protein Domains for ADIRF Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ADIRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADIRF: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ADIRF Gene

Function for ADIRF Gene

Molecular function for ADIRF Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during pre-adipocyte differentiation. Up-regulated following DNA damage induced by UV irradiation.

Gene Ontology (GO) - Molecular Function for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ADIRF: view
genes like me logo Genes that share phenotypes with ADIRF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADIRF Gene

Localization for ADIRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIRF Gene

Gene Ontology (GO) - Cellular Components for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23239344
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ADIRF: view

No data available for Subcellular locations from COMPARTMENTS for ADIRF Gene

Pathways & Interactions for ADIRF Gene

SuperPathways for ADIRF Gene

No Data Available

Interacting Proteins for ADIRF Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361083%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q15847-ADIRF_HUMAN ENSP00000361083 for ADIRF Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for ADIRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IDA 23239344
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 23239344
GO:0071478 cellular response to radiation IDA 23239344
genes like me logo Genes that share ontologies with ADIRF: view

No data available for Pathways by source and SIGNOR curated interactions for ADIRF Gene

Drugs & Compounds for ADIRF Gene

No Compound Related Data Available

Transcripts for ADIRF Gene

mRNA/cDNA for ADIRF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADIRF Gene

Adipogenesis regulatory factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIRF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ADIRF Gene

GeneLoc Exon Structure for
ADIRF
ECgene alternative splicing isoforms for
ADIRF

Expression for ADIRF Gene

mRNA expression in normal human tissues for ADIRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIRF Gene

This gene is overexpressed in Artery - Tibial (x6.5), Artery - Coronary (x4.3), Adipose - Subcutaneous (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for ADIRF Gene

This gene is overexpressed in Nasal epithelium (10.7), Nasopharynx (9.3), Cerebral cortex (9.1), and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADIRF Gene



NURSA nuclear receptor signaling pathways regulating expression of ADIRF Gene:

ADIRF

SOURCE GeneReport for Unigene cluster for ADIRF Gene:

Hs.642660

mRNA Expression by UniProt/SwissProt for ADIRF Gene:

Q15847-ADIRF_HUMAN
Tissue specificity: Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen.
genes like me logo Genes that share expression patterns with ADIRF: view

Primer Products

No data available for Protein tissue co-expression partners for ADIRF Gene

Orthologs for ADIRF Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIRF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C28H10orf116 34
  • 88.16 (n)
  • 85.53 (a)
C28H10ORF116 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H10orf116 34
  • 86.94 (n)
  • 83.78 (a)
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf116 34
  • 98.81 (n)
  • 98.21 (a)
C10ORF116 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIRF 35
  • 66 (a)
OneToOne
Species where no ortholog for ADIRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIRF Gene

ENSEMBL:
Gene Tree for ADIRF (if available)
TreeFam:
Gene Tree for ADIRF (if available)

Paralogs for ADIRF Gene

No data available for Paralogs for ADIRF Gene

Variants for ADIRF Gene

Structural Variations from Database of Genomic Variants (DGV) for ADIRF Gene

Variant ID Type Subtype PubMed ID
esv2759774 CNV gain+loss 17122850
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv470969 CNV loss 18288195
nsv517487 CNV gain+loss 19592680

Variation tolerance for ADIRF Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ADIRF Gene

Disorders for ADIRF Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADIRF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
secondary hypertrophic osteoarthropathy
  • bamberger-marie disease
- elite association - COSMIC cancer census association via MalaCards
Search ADIRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADIRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIRF
genes like me logo Genes that share disorders with ADIRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIRF Gene

Publications for ADIRF Gene

  1. A Novel pro-adipogenesis factor abundant in adipose tissues and over- expressed in obesity acts upstream of PPARgamma and C/EBPalpha. (PMID: 23239344) Ni Y. … Guo X. (J. Bioenerg. Biomembr. 2013) 2 3 4 65
  2. APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status. (PMID: 19444912) Scott B.J. … Ng C.E. (Int. J. Cancer 2009) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). (PMID: 8619847) Maeda K. … Matsubara K. (Biochem. Biophys. Res. Commun. 1996) 2 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for ADIRF Gene

Sources for ADIRF Gene

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