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Aliases & Descriptions for ADIPOR2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ACDCR2 1, 2 | | FLJ21432 2 | | MGC4640 2 | | OTTHUMP00000160634 2 | | PAQR2 1, 2, 3 |
| | | Descriptions |
|---|
| Progestin and adipoQ receptor family member II 3 | | adiponectin receptor 2 2 |
|
| | Search outside databases for aliases for ADIPOR2 genePrevious GC identifer: GC12P001679 |
Summaries for ADIPOR2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ADIPOR2: The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM] UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin |
Genomic Location for ADIPOR2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ADIPOR2 gene 
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13ADIPOR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P001670:
(about GC identifiers)
Start:
|
1,670,508 bp from pter |
End:
|
1,768,106 bp from pter |
Size:
|
97,599 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for ADIPOR2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24 (See
protein sequence)Recommended Name: Adiponectin receptor protein 2 Size: 386 amino acids; 43884 Da
Subunit: May form homo and heteromultimers
Subcellular location: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles
Secondary accessions: Q9H737REFSEQ proteins: NP_078827.2
ENSEMBL proteins: ENSP00000349616
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for ADIPOR2: Assays for ADIPOR2: | Protein
Domains/ Families for ADIPOR2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86V24
ProtoNet protein and cluster: Q86V24 1 Blocks protein family: IPB004254 Hly-III related proteins
UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24Similarity: Belongs to the ADIPOR family | Gene Function for ADIPOR2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024551
Applied Biosystems Silencer® siRNAs for ADIPOR2
Sigma-Aldrich siRNA and siRNA Panels for ADIPOR2  Sigma-Aldrich shRNA for ADIPOR2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024551                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024551                                  untagged cDNA clone in CMV expression vector: NM_024551 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024551
UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Adipor2):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ADIPOR2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADIPOR2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for ADIPOR2 
5/11 Interacting proteins for ADIPOR2 (Q86V241 ENSP000003496163) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for ADIPOR2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ADIPOR2 4 Novoseek chemical compound relationships for ADIPOR2 gene
About this table
|
Transcripts for ADIPOR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024551
Sigma-Aldrich siRNA and siRNA Panels for ADIPOR2  Sigma-Aldrich shRNA for ADIPOR2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024551 REFSEQ mRNAs for ADIPOR2 gene: NM_024551.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024551               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024551                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024551                                  untagged cDNA clone in CMV expression vector: NM_024551  Additional cDNA sequence: AK025085.1 AK127111.1 AK127196.1 AK128511.1 AY424280.1 BC004906.2 BC051858.2 CR610048.1 CR613880.1 16 DOTS entries: DT.445383 DT.121137533 DT.101984550 DT.101976438 DT.92450046 DT.95157752 DT.100657431 DT.121137551 DT.91886273 DT.92450041 DT.121137543 DT.121137614 DT.121137628 DT.40313712 DT.95157758 DT.99995379 24/430 AceView cDNA sequences (see all 430
):BP430930 BU943971 AI191930 CA390994 BI859881 CB160653 AI339454 BP381353 BU539201 BQ431377 BQ431429 AI829022 BU539616 BU629483 AA480644 BF589059 BU736841 BQ279076 AW778845 CR591974 BM666372 AA588196 AA379254 AI205733
highest scoring ESTs for ADIPOR2:AA903403 AA045263 AA045271 AA055331 AA055928 AA121694 AA121748 AA126324 AA130635 AA130738 Unigene Cluster for ADIPOR2: Adiponectin receptor 2 Hs.371642 [show with all ESTs]Unigene Representative Sequence: AK128511
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ADIPOR2
1 Ensembl transcript including schematic representation: ENST00000357103
|
Expression for ADIPOR2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADIPOR2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADIPOR2
1 / 2 / 3 4 probe-sets matching ADIPOR2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.371642
Expression variation in blood from EXPOLDB for ADIPOR2 UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24Tissue specificity: Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung |
Orthologs for ADIPOR2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADIPOR2 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for ADIPOR2
ENSEMBL Gene Tree for ADIPOR2 | Paralogs for ADIPOR2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ADIPOR2 gene
- ADIPOR12 PAQR42 PAQR32
|
SNPs/Variants for ADIPOR2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADIPOR2 (up to first 250kb)
|
Disorders & Mutations for ADIPOR2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607946
10/13 Novoseek disease relationships for ADIPOR2 gene (see all 13
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| insulin sensitivity |
74.72 |
12 |
19037660 (4), 14759511 (1), 16551730 (1), 19169664 (1) (see all 8) |
| insulin resistance |
71.44 |
26 |
15918014 (4), 17216283 (3), 14759511 (2), 17878241 (2) (see all 15) |
| obesity |
61.98 |
12 |
16756736 (2), 17878241 (2), 17607322 (2), 16493120 (1) (see all 9) |
| impaired glucose tolerance |
48.16 |
2 |
17391161 (1), 17878241 (1) |
| fatty liver |
46.56 |
1 |
17006986 (1) |
| liver diseases |
25.23 |
1 |
17006986 (1) |
| dyslipidemia |
21.97 |
2 |
17068142 (1), 16700915 (1) |
| anorexia nervosa |
17.56 |
1 |
17391161 (1) |
| cardiovascular diseases |
17.39 |
1 |
16756736 (1) |
| inflammation |
13.44 |
2 |
19136982 (1), 16700915 (1) |
About this table
Genetic Association Database: ADIPOR2 Human Genome Epidemiology Navigator: ADIPOR2 (21 documents)
|
Medical News for ADIPOR2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ADIPOR2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/121 PubMed articles for ADIPOR2 gene (see all 121
):- Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)2, 3, 4 Yamauchi T.... Kadowaki T. (2003)
- Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)1, 3, 6 Hara K....Kadowaki T. (2005)
- Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. (PubMed id 15983228)1, 3, 6 Damcott C.M....Shuldiner A.R. (2005)
- Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)1, 3, 6 Stefan N....Haring H.U. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)1, 3 Vaxillaire M....Froguel P. (2006)
- The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)1, 3 Rasmussen-Torvik L.J....Sinaiko A.R. (2009)
- Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. (PubMed id 16700915)1, 3 Broedl U.C....Parhofer K.G. (2006)
- Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. (PubMed id 15105989)1, 3 Civitarese A.E....Ravussin E. (2004)
|
Search for ADIPOR2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ADIPOR2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADIPOR2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADIPOR2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Adiponectin |
|
| | | About This Section
| --
| Services for ADIPOR2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ADIPOR2:

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Incremental update: 13 Oct 2009
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