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ADIPOR2 Gene

protein-coding   GIFtS: 62
GCID: GC12P001801

Adiponectin Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adiponectin Receptor 21 2
Progestin And AdipoQ Receptor Family Member II2 3
PAQR22 3
ACDCR22
Adiponectin Receptor Protein 22
FLJ214325

External Ids:    HGNC: 240411   Entrez Gene: 796022   Ensembl: ENSG000000068317   OMIM: 6079465   UniProtKB: Q86V243   
ORGUL members:         

Export aliases for ADIPOR2 gene to outside databases

Previous GC identifers: GC12P001679 GC12P001670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADIPOR2 Gene:
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length
adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand
activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 (PubMed
12802337)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ADIPOR2 Gene:
ADIPOR2 (adiponectin receptor 2) is a protein-coding gene. Diseases associated with ADIPOR2 include meconium ileus in cystic fibrosis, and meconium ileus. GO annotations related to this gene include receptor activity and identical protein binding. An important paralog of this gene is PAQR4.

UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24
Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADIPOR2 gene promoter:
         TBP   GR   LHX3b/Lhx3b   AP-1   ATF-2   PPAR-gamma1   LHX3a/Lhx3a   c-Jun   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADIPOR2 promoter sequence
   Search Chromatin IP Primers for ADIPOR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIPOR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13

ADIPOR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOR2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P001801:  view genomic region     (about GC identifiers)

Start:
1,797,740 bp from pter      End:
1,897,845 bp from pter
Size:
100,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24 (See protein sequence)
Recommended Name: Adiponectin receptor protein 2  
Size: 386 amino acids; 43884 Da
Subunit: May form homomultimer and heteromultimers
Sequence caution: Sequence=BAB15062.1; Type=Erroneous initiation;
Secondary accessions: Q53YY5 Q9H737

Explore the universe of human proteins at neXtProt for ADIPOR2: NX_Q86V24

Explore proteomics data for ADIPOR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADIPOR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078827.2  
    ENSEMBL proteins: 
     ENSP00000349616  

    ADIPOR2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADIPOR: GPCR / Unclassified : Adiponectin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Adipo2 receptor
    Adiponectin receptors

    1 InterPro protein domain:
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q86V24

    ProtoNet protein and cluster: Q86V24

    1 Blocks protein domain: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24
    Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular
    Similarity: Belongs to the ADIPOR family


    ADIPOR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADR2_HUMAN, Q86V24
    Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
    that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
    fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
    adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IBA--
    GO:0005515protein binding ----
    GO:0042562hormone binding ISS12802337
    GO:0042802identical protein binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    ADIPOR2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adipor2):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  nervous system  reproductive system  skeleton 

    ADIPOR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adipor2tm1Tka for ADIPOR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADIPOR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADIPOR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADIPOR2

    miRNA
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    miRTarBase miRNAs that target ADIPOR2:
    hsa-mir-124-3p (MIRT001833), hsa-let-7b-5p (MIRT052228), hsa-mir-375 (MIRT001750)

    Block miRNA regulation of human, mouse, rat ADIPOR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADIPOR2 (see all 77):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-1304 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidADIPOR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADIPOR2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADIPOR2 (NM_024551)
    Sino Biological Human cDNA Clone for ADIPOR2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADR2_HUMAN, Q86V24: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular
    organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IBA--
    GO:0016021integral component of membrane IEA--

    ADIPOR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADIPOR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2AMPK signaling
    AMPK signaling
    3Adipocytokine signaling pathway
    Adipocytokine signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADIPOR2
        AMPK signaling



    2 Kegg Pathways  (Kegg details for ADIPOR2):
        Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)


    ADIPOR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOR2: 
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Fatty Liver in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADIPOR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ADIPOR2 (Q86V241, 3 ENSP000003496164) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG11, 3EBI-1769445,EBI-741243 I2D: score=1 
    ADIPOQQ158483, ENSP000003207094I2D: score=2 STRING: ENSP00000320709
    SCDO007673, ENSP000003593804I2D: score=1 STRING: ENSP00000359380
    LSM1O151163, ENSP000003105964I2D: score=1 STRING: ENSP00000310596
    CAPZA1P529073I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007507heart development IEA--
    GO:0007565female pregnancy IEA--
    GO:0007584response to nutrient IEA--
    GO:0009755hormone-mediated signaling pathway ISS12802337
    GO:0019395fatty acid oxidation ISS12802337

    ADIPOR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADIPOR2 (ADR2)

    8 Novoseek inferred chemical compound relationships for ADIPOR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pioglitazone 56.2 3 17950097 (1), 19169664 (1)
    glucose 53.9 19 17068142 (2), 17878241 (2), 15855268 (1), 18294218 (1) (see all 12)
    fatty acid 41.2 4 20032495 (1), 16055297 (1), 15769985 (1), 19636528 (1)
    lipid 36.4 7 17878241 (2), 17068142 (1), 19502591 (1), 16205883 (1) (see all 5)
    rosiglitazone 33.1 2 15824748 (1), 15991021 (1)
    palmitate 32.8 5 19502591 (2), 19636528 (1), 20470935 (1)
    p003 6.53 1 15105989 (1)
    testosterone 0 1 16899222 (1)



    ADIPOR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADIPOR2 gene: 
    NM_024551.2  

    Unigene Cluster for ADIPOR2:

    Adiponectin receptor 2
    Hs.371642  [show with all ESTs]
    Unigene Representative Sequence: AK128511
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537545 ENST00000357103(uc001qjm.3 uc001qjn.3) ENST00000540974
    ENST00000543456 ENST00000535774 ENST00000544470 ENST00000537190
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADIPOR2 (see all 77):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-1304 hsa-miR-629*
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      QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR2
      QuantiFast Probe-based Assays in human, mouse, rat ADIPOR2

    Additional mRNA sequence: 

    AK025085.1 AK127111.1 AK127196.1 AK128511.1 AY424280.1 BC004906.2 BC051858.2 

    16 DOTS entries:

    DT.445383  DT.121137533  DT.101984550  DT.92450046  DT.95157752  DT.101976438  DT.121137551  DT.100657431 
    DT.91886273  DT.92450041  DT.121137543  DT.121137614  DT.121137628  DT.40313712  DT.95157758  DT.99995379 

    Selected AceView cDNA sequences (see all 430):

    BM797998 BQ439997 BC051858 BG654577 CR610048 BE300753 BU539201 AI869808 
    AI205733 BE268114 AW243796 BU629483 BQ224355 AI382070 BM745137 AI445051 
    BQ005956 BE312641 BQ007901 BI868300 BM771522 BM921518 CR591974 CB123479 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:              -                             -     -                                 
    SP2:                                            -     -                                 
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ADIPOR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADIPOR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTTGAC
    ADIPOR2 Expression
    About this image

    ADIPOR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADIPOR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371642

    UniProtKB/Swiss-Prot: ADR2_HUMAN, Q86V24
    Tissue specificity: Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart,
    colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOR2: 
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Fatty Liver in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADIPOR2
    OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADIPOR2
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    QuantiFast Probe-based Assays in human, mouse, rat ADIPOR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADIPOR2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adipor21 , 5 adiponectin receptor 21, 5 89.64(n)1
    92.75(a)1
      6 (56.78 cM)5
    684651  NM_197985.31  NP_932102.21 
     1193531505 
    chicken
    (Gallus gallus)
    Aves ADIPOR21 adiponectin receptor 2 77.86(n)
    84.9(a)
      418155  NM_001007854.1  NP_001007855.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADIPOR26
    adiponectin receptor 2
    81(a)
    1 ↔ 1
    5(12799686-12818924)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48022 Xenopus laevis transcribed sequence with moderate similarity more 81.19(n)    CA974243.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adipor21 adiponectin receptor 2 72.89(n)
    82.83(a)
      560140  NM_001025506.2  NP_001020677.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53156
    --
    45(a)
    1 → many
    3R(18369415-18373567)
    worm
    (Caenorhabditis elegans)
    Secernentea paqr-16
    paqr-26
    Protein PAQR-2 (paqr-2) mRNA, complete cds
    39(a)
    29(a)
    many ↔ many
    many ↔ many
    IV(6552492-6555890) WBGene00016610
    III(5375698-5379929) WBGene00021313
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IZH2(YOL002C)4 Plasma membrane protein involved in zinc homeostasis more   --   15(324364-323411) 854160  NP_014641.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HHP41 HHP4 48.86(n)
    43.32(a)
      829922  NM_001204017.1  NP_001190946.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02329001 Os03g0232900 49.32(n)
    42.38(a)
      4332161  NM_001056006.1  NP_001049471.1 


    ENSEMBL Gene Tree for ADIPOR2 (if available)
    TreeFam Gene Tree for ADIPOR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADIPOR2 gene
    PAQR42  ADIPOR12  PAQR32  
    2 SIMAP similar genes for ADIPOR2 using alignment to 1 protein entry:     ADR2_HUMAN:
    ADIPOR1    PAQR3

    ADIPOR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADIPOR2
    PGOHUM00000238696


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADIPOR2 (see all 2049)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349953041,2
    C--1737565(+) TTTTT-/T/TT  
            
    CTAAA
    1 -- int12NA 4
    rs668421561,2
    C--1769524(-) TTGTT-/A/AAA 
            
    AAAAA
    1 -- int12NA 4
    rs1510087161,2
    --1798267(+) TCATCC/TGGTTC 1 -- us2k10--------
    rs3773909121,2
    C--1798285(+) GGTGAA/CTGTTC 1 -- us2k10--------
    rs1855870371,2
    --1798294(+) TTCCAA/GAGGTA 1 -- us2k10--------
    rs79707951,2
    A,H--1798316(+) CCCTTC/TGTTTT 1 -- us2k12Minor allele frequency- T:0.00NS 240
    rs1408569931,2
    --1798462(+) TCCAGA/CGTACC 1 -- us2k10--------
    rs1447857751,2
    --1798486(+) ACGCGC/TGACCA 1 -- us2k10--------
    rs79710571,2
    A--1798524(+) agagaC/Tggggt 1 -- us2k10--------
    rs1467153881,2
    --1798528(+) ACGGGG/TTTTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADIPOR2 (1797740 - 1897845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADIPOR2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745396CNV Deletion23290073
    esv2662489CNV Deletion23128226
    esv1263717CNV Deletion17803354
    esv2586584CNV Deletion19546169
    esv2745395CNV Deletion23290073
    esv2745398CNV Deletion23290073
    esv3783CNV Deletion18987735
    esv994937CNV Deletion20482838
    esv273440CNV Insertion20981092
    nsv832306CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADIPOR2
    DNA2.0 Custom Variant and Variant Library Synthesis for ADIPOR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607946    OMIM disorders: --

    Selected diseases for ADIPOR2 (see all 45):    
    About MalaCards
    meconium ileus in cystic fibrosis    meconium ileus    ileus    nonalcoholic steatohepatitis
    fatty liver disease    insulin resistance    anorexia nervosa    liver disease
    morbid obesity    gastrointestinal stromal tumor    obesity    polycystic ovary syndrome
    chondrosarcoma    liver cirrhosis    prader-willi syndrome    chronic myeloid leukemia
    type 1 diabetes mellitus    diabetes mellitus    papillary thyroid carcinoma    coronary artery disease

    2 diseases from the University of Copenhagen DISEASES database for ADIPOR2:
    Diabetes mellitus     Fatty liver disease

    ADIPOR2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ADIPOR2 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 75 12 19037660 (4), 14759511 (1), 16551730 (1), 19169664 (1) (see all 8)
    insulin resistance 72.5 29 15918014 (4), 17216283 (3), 14759511 (2), 17716299 (2) (see all 17)
    obesity 61.2 13 16756736 (2), 17878241 (2), 17607322 (2), 16493120 (1) (see all 10)
    fatty liver 48.2 1 17006986 (1)
    impaired glucose tolerance 43.2 2 17391161 (1), 17878241 (1)
    liver diseases 28.1 1 17006986 (1)
    dyslipidemia 15.2 2 17068142 (1), 16700915 (1)
    inflammation 15.2 2 19136982 (1), 16700915 (1)
    cardiovascular diseases 14.8 1 16756736 (1)
    anorexia nervosa 12 1 17391161 (1)

    Genetic Association Database (GAD): ADIPOR2
    Human Genome Epidemiology (HuGE) Navigator: ADIPOR2 (37 documents)

    Export disorders for ADIPOR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADIPOR2 gene, integrated from 10 sources (see all 195):
    (articles sorted by number of sources associating them with ADIPOR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)1, 2, 3 Yamauchi T.... Kadowaki T. (Nature 2003)
    2. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. (PubMed id 20178558)1, 4, 9 Halvatsiotis I....Raptis S.A. (Cardiovasc Diabetol 2010)
    3. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)1, 4, 9 Vaxillaire M....Froguel P. (Diabetes 2006)
    4. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)1, 4, 9 Hara K....Kadowaki T. (Diabetologia 2005)
    5. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)1, 4, 9 Rasmussen-Torvik L.J....Sinaiko A.R. (Hum. Genet. 2009)
    6. Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. (PubMed id 16700915)1, 4, 9 Broedl U.C....Parhofer K.G. (Cardiovasc Diabetol 2006)
    7. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. (PubMed id 15983228)1, 4, 9 Damcott C.M....Shuldiner A.R. (Diabetes 2005)
    8. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PubMed id 19208777)1, 4, 9 Kotronen A....Fisher R.M. (Eur. J. Endocrinol. 2009)
    9. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis. (PubMed id 17416799)1, 4, 9 Qi L....Hu F.B. (Diabetes 2007)
    10. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)1, 4, 9 Stefan N....HAoring H.U. (Diabetologia 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79602 HGNC: 24041 AceView: ADIPOR2 Ensembl:ENSG00000006831 euGenes: HUgn79602
    ECgene: ADIPOR2 Kegg: 79602 H-InvDB: ADIPOR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADIPOR2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Adiponectin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADIPOR2 gene:
    Search GeneIP for patents involving ADIPOR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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