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Aliases for ADIPOR2 Gene

Aliases for ADIPOR2 Gene

  • Adiponectin Receptor 2 2 3 5
  • Progestin And AdipoQ Receptor Family Member II 3 4
  • PAQR2 3 4
  • Adiponectin Receptor Protein 2 3
  • ACDCR2 3

External Ids for ADIPOR2 Gene

Previous GeneCards Identifiers for ADIPOR2 Gene

  • GC12P001679
  • GC12P001801

Summaries for ADIPOR2 Gene

Entrez Gene Summary for ADIPOR2 Gene

  • The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIPOR2 Gene

ADIPOR2 (Adiponectin Receptor 2) is a Protein Coding gene. Diseases associated with ADIPOR2 include Fatty Liver Disease and Liver Disease. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include identical protein binding and receptor activity. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for ADIPOR2 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOR2 Gene

Genomics for ADIPOR2 Gene

Regulatory Elements for ADIPOR2 Gene

Enhancers for ADIPOR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F001658 1.5 FANTOM5 ENCODE 19.3 -27.3 -27289 5.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF416 FOS ADIPOR2 CACNA1C-AS3 CACNA1C-IT3 CACNA2D4 ENSG00000256706 DCP1B LRTM2 MIR3649
GH12F001719 1.1 Ensembl 17.3 +31.2 31227 0.4 WT1 ADIPOR2 LOC100533654 GC12M001758
GH12F001665 1.5 FANTOM5 Ensembl ENCODE 12.8 -20.1 -20067 7.0 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 KLF7 FOS SP5 CACNA2D4 ADIPOR2 ENSG00000256706 MIR3649
GH12F001657 1.1 ENCODE 11.9 -30.7 -30725 0.2 KLF1 CEBPB ADIPOR2 MIR3649 FBXL14
GH12F001720 0.2 ENCODE 11.8 +32.1 32143 0.1 ZNF610 POLR2A ZIC2 ADIPOR2 CACNA2D4 LOC100533654 GC12M001758
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADIPOR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADIPOR2 Gene

Chromosome:
12
Start:
1,688,574 bp from pter
End:
1,788,679 bp from pter
Size:
100,106 bases
Orientation:
Plus strand

Genomic View for ADIPOR2 Gene

Genes around ADIPOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR2 Gene

Proteins for ADIPOR2 Gene

  • Protein details for ADIPOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V24-ADR2_HUMAN
    Recommended name:
    Adiponectin receptor protein 2
    Protein Accession:
    Q86V24
    Secondary Accessions:
    • Q53YY5
    • Q9H737

    Protein attributes for ADIPOR2 Gene

    Size:
    386 amino acids
    Molecular mass:
    43884 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR1.
    SequenceCaution:
    • Sequence=BAB15062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR2 Gene

neXtProt entry for ADIPOR2 Gene

Post-translational modifications for ADIPOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIPOR2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ADIPOR2

No data available for DME Specific Peptides for ADIPOR2 Gene

Domains & Families for ADIPOR2 Gene

Protein Domains for ADIPOR2 Gene

Suggested Antigen Peptide Sequences for ADIPOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V24

UniProtKB/Swiss-Prot:

ADR2_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR2: view

Function for ADIPOR2 Gene

Molecular function for ADIPOR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Gene Ontology (GO) - Molecular Function for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
GO:0055100 adiponectin binding IDA 12802337
GO:0097003 adipokinetic hormone receptor activity IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view
genes like me logo Genes that share phenotypes with ADIPOR2: view

Animal Models for ADIPOR2 Gene

MGI Knock Outs for ADIPOR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADIPOR2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOR2 Gene

Localization for ADIPOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOR2 Gene COMPARTMENTS Subcellular localization image for ADIPOR2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view

Pathways & Interactions for ADIPOR2 Gene

genes like me logo Genes that share pathways with ADIPOR2: view

SIGNOR curated interactions for ADIPOR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007507 heart development IEA --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with ADIPOR2: view

Drugs & Compounds for ADIPOR2 Gene

(5) Drugs for ADIPOR2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AdipoRon Pharma 0

(4) Additional Compounds for ADIPOR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADIPOR2 Gene

Compound Action Cas Number
AdipoRon 924416-43-3
genes like me logo Genes that share compounds with ADIPOR2: view

Transcripts for ADIPOR2 Gene

Unigene Clusters for ADIPOR2 Gene

Adiponectin receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for ADIPOR2 Gene

GeneLoc Exon Structure for
ADIPOR2
ECgene alternative splicing isoforms for
ADIPOR2

Expression for ADIPOR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADIPOR2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADIPOR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADIPOR2 Gene:

ADIPOR2

SOURCE GeneReport for Unigene cluster for ADIPOR2 Gene:

Hs.371642

mRNA Expression by UniProt/SwissProt for ADIPOR2 Gene:

Q86V24-ADR2_HUMAN
Tissue specificity: Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).
genes like me logo Genes that share expression patterns with ADIPOR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ADIPOR2 Gene

Orthologs for ADIPOR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOR2 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia ADIPOR2 34 35
  • 92.66 (n)
rat
(Rattus norvegicus)
Mammalia Adipor2 34
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Adipor2 34 16 35
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia ADIPOR2 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADIPOR2 34 35
  • 86.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADIPOR2 34 35
  • 77.86 (n)
lizard
(Anolis carolinensis)
Reptilia ADIPOR2 35
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4802 34
zebrafish
(Danio rerio)
Actinopterygii adipor2 34 35
  • 72.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11010 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004486 34
  • 59.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5315 35
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea paqr-1 35
  • 39 (a)
ManyToMany
paqr-2 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH2 35 37
  • 36 (a)
ManyToMany
IZH1 35
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HHP4 34
  • 48.86 (n)
rice
(Oryza sativa)
Liliopsida Os03g0232900 34
  • 49.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8140 35
  • 50 (a)
OneToMany
Species where no ortholog for ADIPOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADIPOR2 Gene

ENSEMBL:
Gene Tree for ADIPOR2 (if available)
TreeFam:
Gene Tree for ADIPOR2 (if available)

Paralogs for ADIPOR2 Gene

Paralogs for ADIPOR2 Gene

(2) SIMAP similar genes for ADIPOR2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ADIPOR2 Gene

genes like me logo Genes that share paralogs with ADIPOR2: view

Variants for ADIPOR2 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082811 -- 1,754,699(+) TATTA(C/T)TACTA intron-variant
rs10082860 -- 1,718,914(+) GTGTA(A/G)TGATA intron-variant
rs10082890 -- 1,755,051(+) ATTTT(A/G)ATTTT intron-variant
rs10161408 -- 1,779,507(+) agggc(C/T)gtaag intron-variant
rs1029629 -- 1,690,101(-) TCCTT(A/C)CCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADIPOR2 Gene

Variant ID Type Subtype PubMed ID
dgv751n106 CNV deletion 24896259
esv1263717 CNV deletion 17803354
esv2586584 CNV deletion 19546169
esv2662489 CNV deletion 23128226
esv2745395 CNV deletion 23290073
esv2745396 CNV deletion 23290073
esv2745398 CNV deletion 23290073
esv3309167 CNV mobile element insertion 20981092
esv3391809 CNV insertion 20981092
esv3548628 CNV deletion 23714750
esv3628291 CNV loss 21293372
esv3628293 CNV loss 21293372
esv3783 CNV loss 18987735
esv994937 CNV deletion 20482838
nsv1045312 CNV loss 25217958
nsv1071001 CNV deletion 25765185
nsv1145579 CNV deletion 24896259
nsv510285 OTHER sequence alteration 20534489
nsv53173 CNV deletion 16902084
nsv556996 CNV gain 21841781
nsv832304 CNV gain 17160897
nsv832305 CNV gain 17160897
nsv832306 CNV loss 17160897
nsv952786 CNV duplication 24416366
nsv957269 CNV deletion 24416366
nsv973980 CNV duplication 23825009
nsv983262 CNV duplication 23825009

Variation tolerance for ADIPOR2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIPOR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIPOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Disorders for ADIPOR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADIPOR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
liver disease
  • disorder of liver
obesity
  • obesity, association with
meconium ileus
  • intestinal obstruction in the newborn due to guanylate cyclase 2c deficiency
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADIPOR2

Genetic Association Database (GAD)
ADIPOR2
Human Genome Epidemiology (HuGE) Navigator
ADIPOR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIPOR2
genes like me logo Genes that share disorders with ADIPOR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR2 Gene

Publications for ADIPOR2 Gene

  1. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson J.F. … Roche H.M. (Am. J. Clin. Nutr. 2010) 3 22 46 64
  2. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. (PMID: 20178558) Halvatsiotis I. … Raptis S.A. (Cardiovasc Diabetol 2010) 3 22 46 64
  3. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) RuaA+o G. … Hanks S. (Clin. Chim. Acta 2009) 3 22 46 64
  4. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. (PMID: 19631916) Wang Y. … Xu H. (J Genet Genomics 2009) 3 22 46 64
  5. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PMID: 19037660) Rasmussen-Torvik L.J. … Sinaiko A.R. (Hum. Genet. 2009) 3 22 46 64

Products for ADIPOR2 Gene

Sources for ADIPOR2 Gene

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