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Aliases for ADIPOR2 Gene

Aliases for ADIPOR2 Gene

  • Adiponectin Receptor 2 2 3
  • Progestin And AdipoQ Receptor Family Member II 3 4
  • PAQR2 3 4
  • ACDCR2 3

External Ids for ADIPOR2 Gene

Previous GeneCards Identifiers for ADIPOR2 Gene

  • GC12P001679
  • GC12P001801

Summaries for ADIPOR2 Gene

Entrez Gene Summary for ADIPOR2 Gene

  • The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIPOR2 Gene

ADIPOR2 (Adiponectin Receptor 2) is a Protein Coding gene. Diseases associated with ADIPOR2 include meconium ileus and fatty liver disease. Among its related pathways are Adipocytokine signaling pathway and Alzheimers disease. GO annotations related to this gene include identical protein binding and receptor activity. An important paralog of this gene is ADIPOR1.

UniProtKB/Swiss-Prot for ADIPOR2 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOR2 Gene

Genomics for ADIPOR2 Gene

Regulatory Elements for ADIPOR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADIPOR2 Gene

Chromosome:
12
Start:
1,688,574 bp from pter
End:
1,788,679 bp from pter
Size:
100,106 bases
Orientation:
Plus strand

Genomic View for ADIPOR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADIPOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR2 Gene

Proteins for ADIPOR2 Gene

  • Protein details for ADIPOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V24-ADR2_HUMAN
    Recommended name:
    Adiponectin receptor protein 2
    Protein Accession:
    Q86V24
    Secondary Accessions:
    • Q53YY5
    • Q9H737

    Protein attributes for ADIPOR2 Gene

    Size:
    386 amino acids
    Molecular mass:
    43884 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR1.
    SequenceCaution:
    • Sequence=BAB15062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR2 Gene

neXtProt entry for ADIPOR2 Gene

Proteomics data for ADIPOR2 Gene at MOPED

Post-translational modifications for ADIPOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIPOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADIPOR2 Gene

Domains & Families for ADIPOR2 Gene

Protein Domains for ADIPOR2 Gene

Suggested Antigen Peptide Sequences for ADIPOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V24

UniProtKB/Swiss-Prot:

ADR2_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR2: view

Function for ADIPOR2 Gene

Molecular function for ADIPOR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Gene Ontology (GO) - Molecular Function for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0042562 hormone binding IBA --
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ADIPOR2: view
genes like me logo Genes that share phenotypes with ADIPOR2: view

Animal Models for ADIPOR2 Gene

MGI Knock Outs for ADIPOR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADIPOR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADIPOR2 Gene

Localization for ADIPOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOR2 Gene COMPARTMENTS Subcellular localization image for ADIPOR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view

Pathways & Interactions for ADIPOR2 Gene

genes like me logo Genes that share pathways with ADIPOR2: view

Pathways by source for ADIPOR2 Gene

1 BioSystems pathway for ADIPOR2 Gene

PCR Array Products

SIGNOR curated interactions for ADIPOR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12802337
GO:0007507 heart development IEA --
GO:0007565 female pregnancy IEA --
GO:0007584 response to nutrient IEA --
GO:0009755 hormone-mediated signaling pathway ISS 12802337
genes like me logo Genes that share ontologies with ADIPOR2: view

Drugs & Compounds for ADIPOR2 Gene

(4) Drugs for ADIPOR2 Gene - From: ApexBio and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pioglitazone Approved, Investigational Pharma Channel blocker 405
Rosiglitazone Approved, Investigational Pharma Channel blocker Potent PPARγ agonist 219
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
AdipoRon Pharma 0

(5) Additional Compounds for ADIPOR2 Gene - From: NovoSeek

genes like me logo Genes that share compounds with ADIPOR2: view

Transcripts for ADIPOR2 Gene

Unigene Clusters for ADIPOR2 Gene

Adiponectin receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADIPOR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for ADIPOR2 Gene

GeneLoc Exon Structure for
ADIPOR2
ECgene alternative splicing isoforms for
ADIPOR2

Expression for ADIPOR2 Gene

mRNA expression in normal human tissues for ADIPOR2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADIPOR2 Gene



SOURCE GeneReport for Unigene cluster for ADIPOR2 Gene Hs.371642

mRNA Expression by UniProt/SwissProt for ADIPOR2 Gene

Q86V24-ADR2_HUMAN
Tissue specificity: Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).
genes like me logo Genes that share expression patterns with ADIPOR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ADIPOR2 Gene

Orthologs for ADIPOR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADIPOR2 35
  • 86.87 (n)
  • 92.23 (a)
ADIPOR2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIPOR2 35
  • 92.66 (n)
  • 96.37 (a)
ADIPOR2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adipor2 35
  • 89.64 (n)
  • 92.75 (a)
Adipor2 16
Adipor2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADIPOR2 35
  • 99.57 (n)
  • 100 (a)
ADIPOR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adipor2 35
  • 89.72 (n)
  • 93.26 (a)
oppossum
(Monodelphis domestica)
Mammalia ADIPOR2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADIPOR2 35
  • 77.86 (n)
  • 84.9 (a)
ADIPOR2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADIPOR2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4802 35
zebrafish
(Danio rerio)
Actinopterygii adipor2 35
  • 72.89 (n)
  • 82.83 (a)
adipor2 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11010 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004486 35
  • 59.35 (n)
  • 57.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5315 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea paqr-1 36
  • 39 (a)
ManyToMany
paqr-2 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 36
  • 30 (a)
ManyToMany
IZH2 36
  • 36 (a)
ManyToMany
IZH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HHP4 35
  • 48.86 (n)
  • 43.32 (a)
rice
(Oryza sativa)
Liliopsida Os03g0232900 35
  • 49.32 (n)
  • 42.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8140 36
  • 50 (a)
OneToMany
Species with no ortholog for ADIPOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADIPOR2 Gene

ENSEMBL:
Gene Tree for ADIPOR2 (if available)
TreeFam:
Gene Tree for ADIPOR2 (if available)

Paralogs for ADIPOR2 Gene

Paralogs for ADIPOR2 Gene

(2) SIMAP similar genes for ADIPOR2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ADIPOR2 Gene

genes like me logo Genes that share paralogs with ADIPOR2: view

Variants for ADIPOR2 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs56395738 -- 1,738,210(+) AAAAA(-/A)GTTAA intron-variant
rs56396021 -- 1,774,955(+) GCCTC(A/G)GCCTC intron-variant
rs56401114 -- 1,745,054(+) GCCCA(A/G)TGATT intron-variant
rs56705398 -- 1,740,496(+) CCCCC(-/C)ACCTT intron-variant
rs56710563 -- 1,729,406(+) ATGAT(A/G)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADIPOR2 Gene

Variant ID Type Subtype PubMed ID
nsv832304 CNV Gain 17160897
nsv832305 CNV Gain 17160897
nsv510285 CNV Loss 20534489
nsv832306 CNV Loss 17160897
esv3783 CNV Deletion 18987735
esv2745395 CNV Deletion 23290073
esv2662489 CNV Deletion 23128226
nsv53173 CNV Loss 16902084
esv2586584 CNV Deletion 19546169
esv2745396 CNV Deletion 23290073
esv1263717 CNV Deletion 17803354
esv994937 CNV Deletion 20482838
esv273440 CNV Insertion 20981092
esv2745398 CNV Deletion 23290073

Variation tolerance for ADIPOR2 Gene

Residual Variation Intolerance Score: 27.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIPOR2 Gene

HapMap Linkage Disequilibrium report
ADIPOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOR2 Gene

Disorders for ADIPOR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADIPOR2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
meconium ileus
  • meconium plug syndrome
fatty liver disease
  • steatosis of liver
liver disease
  • hepatic disorder
obesity
  • obesity, association with
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association

Relevant External Links for ADIPOR2

Genetic Association Database (GAD)
ADIPOR2
Human Genome Epidemiology (HuGE) Navigator
ADIPOR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIPOR2
genes like me logo Genes that share disorders with ADIPOR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR2 Gene

Publications for ADIPOR2 Gene

  1. ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. (PMID: 20074551) Charlton H.K. … Whitehead J.P. (Biochem. Biophys. Res. Commun. 2010) 23 67
  2. Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans. (PMID: 20125105) Felder T.K. … Patsch W. (Int J Obes (Lond) 2010) 23 67
  3. Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development. (PMID: 20219117) Maillard V. … Dupont J. (Reprod. Biol. Endocrinol. 2010) 23 67
  4. Expression levels of adiponectin receptors and periodontitis. (PMID: 20470261) Yamaguchi N. … Yamashita Y. (J. Periodont. Res. 2010) 23 67
  5. Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals. (PMID: 20470935) Bauer S. … Buechler C. (Arch. Med. Res. 2010) 23 67

Products for ADIPOR2 Gene

Sources for ADIPOR2 Gene

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