Aliases for ADIPOR2 Gene
External Ids for ADIPOR2 Gene
Previous GeneCards Identifiers for ADIPOR2 Gene
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ADIPOR2 Gene
ADIPOR2 (Adiponectin Receptor 2) is a Protein Coding gene. Diseases associated with ADIPOR2 include Fatty Liver Disease and Liver Disease. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include identical protein binding and receptor activity. An important paralog of this gene is ADIPOR1.
UniProtKB/Swiss-Prot for ADIPOR2 Gene
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).