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ADIPOR1 Gene

protein-coding GIFtS: 61
GCID: GC01M202909

Adiponectin Receptor 1

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Adiponectin Receptor 1¹ ²		CGI45² ⁵
Progestin And AdipoQ Receptor Family Member I² ³		ACDCR1²
PAQR1² ³		Adiponectin Receptor Protein 1²
TESBP1A² ³

External Ids:	HGNC: 24040¹	Entrez Gene: 51094²	Ensembl: ENSG00000159346⁷	OMIM: 607945⁵	UniProtKB: Q96A54³

Export aliases for ADIPOR1 gene to outside databases

Previous GC identifers: GC01M199376 GC01M200198 GC01M199641 GC01M201176 GC01M174075

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADIPOR1 Gene:

This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which

regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in

activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin

sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript

variants have been found for this gene. (provided by RefSeq, Mar 2014)

GeneCards Summary for ADIPOR1 Gene:

ADIPOR1 (adiponectin receptor 1) is a protein-coding gene. Diseases associated with ADIPOR1 include nonalcoholic steatohepatitis, and anorexia nervosa. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is PAQR4.

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54

Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes

that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as

fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by

adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length

adiponectin

Gene Wiki entry for ADIPOR1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the ADIPOR1 gene promoter:
CREB deltaCREB Lmo2 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADIPOR1 promoter sequence

Search Chromatin IP Primers for ADIPOR1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIPOR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOR1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M202909: view genomic region (about GC identifiers)

Start:	202,909,951 bp from pter	End:	202,927,700 bp from pter
Size:	17,750 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 (See protein sequence)

Recommended Name: Adiponectin receptor protein 1

Size: 375 amino acids; 42616 Da

Subunit: May form homomultimer and heteromultimers

Sequence caution: Sequence=AAD34040.1; Type=Frameshift; Positions=369;

Secondary accessions: B3KMB0 Q53HS7 Q53YY6 Q9Y360

Explore the universe of human proteins at neXtProt for ADIPOR1: NX_Q96A54

Explore proteomics data for ADIPOR1 at MOPED

Post-translational modifications:

Ubiquitination² at Lys86

Modification sites at PhosphoSitePlus

See ADIPOR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001277482.1 NP_001277486.1 NP_001277558.1 NP_057083.2

ENSEMBL proteins:

ENSP00000341785 ENSP00000402178 ENSP00000392946 ENSP00000395469 ENSP00000356223

ADIPOR1 Human Recombinant Protein Products:

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ADIPOR1 Antibody Products:

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	Novus Biologicals ADIPOR1 Antibodies
	Abcam antibodies for ADIPOR1
	Cloud-Clone Corp. Antibodies for ADIPOR1
	ThermoFisher Antibody for ADIPOR1
	LSBio Antibodies in human, mouse, rat for ADIPOR1

ADIPOR1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for ADIPOR1
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	Cloud-Clone Corp. ELISAs for ADIPOR1 Cloud-Clone Corp. CLIAs for ADIPOR1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ADIPOR: GPCR / Unclassified : Adiponectin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Adipo1 receptor

Adiponectin receptors

1 InterPro protein domain:

IPR004254 HlyIII-related

Graphical View of Domain Structure for InterPro Entry Q96A54

ProtoNet protein and cluster: Q96A54

1 Blocks protein domain: IPB004254 Hly-III related proteins

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54

Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular

Similarity: Belongs to the ADIPOR family

ADIPOR1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ADR1_HUMAN, Q96A54

Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes

that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as

fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by

adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length

adiponectin

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IBA	--
GO:0005515	protein binding	--	--
GO:0019901	protein kinase binding	IPI	19233263
GO:0042562	hormone binding	IDA	12802337
GO:0042802	identical protein binding	IEA	--

ADIPOR1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADIPOR1:

Decreased POU5F1-GFP protein e

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adipor1):

adipose tissue	behavior/neurological	cellular	growth/size/body	homeostasis/metabolism
liver/biliary system	muscle	normal	skeleton

ADIPOR1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Adipor1^tm1Tka for ADIPOR1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADIPOR1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADIPOR1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADIPOR1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADIPOR1

miRNA Products:		miRTarBase miRNAs that target ADIPOR1: hsa-mir-197-3p (MIRT048047)

		Block miRNA regulation of human, mouse, rat ADIPOR1 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate ADIPOR1:
		hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
		SwitchGear 3'UTR luciferase reporter plasmid: ADIPOR1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ADIPOR1
		Predesigned siRNA for gene silencing in human, mouse, rat ADIPOR1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADIPOR1

Clone Products:		OriGene clones in human, mouse for ADIPOR1 (see all 12) OriGene ORF clones in mouse, rat for ADIPOR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOR1 (NM_015999)
		Sino Biological Human cDNA Clone for ADIPOR1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADIPOR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADIPOR1
		Browse ESI BIO Cell Lines and PureStem Progenitors for ADIPOR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ADR1_HUMAN, Q96A54: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular

organelles

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
nucleus	2
peroxisome	2
endoplasmic reticulum	1
extracellular	1
golgi apparatus	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	19233263
GO:0016021	integral component of membrane	NAS	12802337

ADIPOR1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ADIPOR1 About

See pathways by source

SuperPath

Contained pathways About

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Non-alcoholic fatty liver disease (NAFLD)

0.41

AMPK signaling

AMPK signaling

Adipocytokine signaling pathway

Adipocytokine signaling pathway

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for ADIPOR1

AMPK signaling

2 Kegg Pathways (Kegg details for ADIPOR1):

	Adipocytokine signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)

ADIPOR1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including ADIPOR1:

Insulin Resistance in human mouse rat

Obesity in human mouse rat

Fatty Liver in human mouse rat

Interactions:

GeneGlobe Interaction Network for ADIPOR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for ADIPOR1 (Q96A54^{1, 3} ENSP00000341785⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APPL1	Q9UKG1¹^,³, ENSP00000288266⁴	EBI-1632076,EBI-741243 I2D: score=2 STRING: ENSP00000288266
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
APPL2	Q8NEU8³, ENSP00000258530⁴	I2D: score=1 STRING: ENSP00000258530
ADIPOR1	Q96A54¹	EBI-1632076,EBI-1632076
ADIPOQ	ENSP00000320709⁴	STRING: ENSP00000320709

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Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009755	hormone-mediated signaling pathway	IDA	12802337
GO:0019395	fatty acid oxidation	IDA	12802337
GO:0030308	negative regulation of cell growth	IEA	--
GO:0033210	leptin-mediated signaling pathway	IEA	--
GO:0033211	adiponectin-activated signaling pathway	IBA	--

ADIPOR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ADIPOR1 (ADR1)

Selected Novoseek inferred chemical compound relationships for ADIPOR1 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	52.6	25	17426101 (2), 18294218 (2), 17878241 (2), 17285539 (2) (see all 15)
fatty acid	50.4	9	20032495 (2), 16603155 (1), 17786081 (1), 16055297 (1) (see all 8)
pioglitazone	43.5	6	16023994 (1), 19169664 (1)
c-peptide	42.8	1	15331527 (1)
lipid	33.5	7	20032495 (1), 16023994 (1), 18288417 (1), 16756736 (1) (see all 6)
rosiglitazone	18.1	6	15991021 (4), 15824748 (1)
p002	5.68	2	15991021 (1)
p003	3.48	1	15105989 (1)
cholesterol	0	1	15331527 (1)
steroid	0	2	19453184 (1), 19671624 (1)

ADIPOR1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ADIPOR1 gene (4 alternative transcripts):

NM_001290553.1 NM_001290557.1 NM_001290629.1 NM_015999.5

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340990(uc010pqd.2 uc001gyq.4 uc001gyr.4) ENST00000495562

ENST00000417068 ENST00000426229 ENST00000436244(uc001gys.4) ENST00000367254

miRNA Products:		Block miRNA regulation of human, mouse, rat ADIPOR1 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate ADIPOR1:
		hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
		SwitchGear 3'UTR luciferase reporter plasmid: ADIPOR1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ADIPOR1
		Predesigned siRNA for gene silencing in human, mouse, rat ADIPOR1

Clone Products:		OriGene clones in human, mouse for ADIPOR1 (see all 12) OriGene ORF clones in mouse, rat for ADIPOR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOR1 (NM_015999)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADIPOR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR1

Primer Products:		OriGene qPCR primer pairs and template standards for ADIPOR1 OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ADIPOR1
		QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR1
		QuantiFast Probe-based Assays in human, mouse, rat ADIPOR1

Selected AceView cDNA sequences (see all 569):

CK823852 BX105151 BX448414 BM788473 CR609684 CR596678 BM783093 BX349860

BC010743 CR596346 BI917225 BM470119 BM783069 AU123343 CB133926 BG283299

AI220633 AI700668 CR608908 BC001594 CR610540 CA489803 AW752990 AU099335

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	^	13a	·
SP1:									-		-		-		-						-																				-
SP2:			-		-		-		-		-		-								-
SP3:									-		-		-								-
SP4:											-		-								-
SP5:									-		-		-		-				-		-		-		-		-		-		-										-

ExUns:	13b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ADIPOR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADIPOR1 expression in normal human tissues (normalized intensities) ADIPOR1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAGTGTGTC

About this image

ADIPOR1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Blood (Hematopoietic System)
Granulocytes Peripheral Blood

Eye (Sensory Organs)
Retina

Pancreas (Endocrine System)

ADIPOR1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ADIPOR1 Protein Expression

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54

Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in

brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon,

thymus and small intestine

Pathway & Disease-focused RT² Profiler PCR Arrays including ADIPOR1:

Insulin Resistance in human mouse rat

Obesity in human mouse rat

Fatty Liver in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for ADIPOR1 OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ADIPOR1
		QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR1
		QuantiFast Probe-based Assays in human, mouse, rat ADIPOR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR1 gene from Selected species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adipor1^{1 , 5}	adiponectin receptor 1^{1, 5}	90.93(n)¹ 96.8(a)¹		1 (58.22 cM)⁵ 72674¹ NM_028320.3¹ NP_082596.2¹ 134415378⁵
chicken (Gallus gallus)	Aves	ADIPOR1¹	adiponectin receptor 1	80.12(n) 91.44(a)		421148 NM_001031027.1 NP_001026198.1
lizard (Anolis carolinensis)	Reptilia	ADIPOR1⁶	adiponectin receptor 1	92(a)	1 ↔ 1	GL344118.1(30058-52076)
African clawed frog (Xenopus laevis)	Amphibia	adipor1-prov²	adiponectin receptor 1	78.92(n)		BC044035.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4053²	Danio rerio mRNA similar to RIKEN cDNA 2810031L11 gene more	77.67(n)		BC044388.1
fruit fly (Drosophila melanogaster)	Insecta	CG5315¹	CG5315	58.38(n) 56.67(a)		42656 NM_170020.2 NP_732759.2
worm (Caenorhabditis elegans)	Secernentea	paqr-1¹	paqr-1	58.73(n) 57.14(a)		177416 NM_068597.5 NP_500998.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	IZH3(YLR023C)⁴ IZH2¹	Membrane protein involved in zinc ion homeostasis, more⁴ IZH2¹	44.9(n)¹ 37.31(a)¹		12(187129-185498)⁴ 854160¹ NP_014641.2¹ 850710⁴ NP_013123.1⁴
rice (Oryza sativa)	Liliopsida	Os12g0511200¹	Os12g0511200	48.44(n) 39.7(a)		4352324 NM_001073399.1 NP_001066867.1

ENSEMBL Gene Tree for ADIPOR1 (if available)
TreeFam Gene Tree for ADIPOR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ADIPOR1 gene

PAQR4² PAQR3² ADIPOR2²

2 SIMAP similar genes for ADIPOR1 using alignment to 4 protein entries: ADR1_HUMAN (see all proteins):

ADIPOR2 PAQR3

ADIPOR1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADIPOR1
PGOHUM00000248258

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186128195^1,2		--	202909460(+)	`TTACCC/TTCCCG`	2	--	int¹		0	--	--	--	--
rs200377097^1,2		--	202909493(+)	`ACCAC-/CACACGA`	2	--	int¹		0	--	--	--	--
rs66513623^1,2	C	--	202909497(+)	`CCACG-/ATAGGCT`	2	--	int¹		0	--	--	--	--
rs77346003^1,2	C	--	202909593(+)	`CTCAGA/TCTCCC`	2	--	int¹		0	--	--	--	--
rs6427981^1,2	C,F,A	--	202909603(+)	`CAAAGT/CGTTGG`	2	--	int¹		5		NA	10
rs112157616^1,2	C,F	--	202909619(+)	`CAGGCG/ATGAGC`	2	--	int¹		2		WA CSA	4
rs78337724^1,2	C,F	--	202909662(+)	`TTGAAC/TACTAC`	2	--	int¹		3		WA NA EA	358
rs138970487^1,2	C	--	202909693(+)	`AACAAA/GATGGT`	2	--	int¹		0	--	--	--	--
rs56934600^1,2	C,F	--	202909737(+)	`AATTTA/TAAAAT`	2	--	int¹		6		WA NA CSA EA	363
rs7539542^1,2	C,F,A,H	--	202909974(+)	`CAAGTG/CTCTTC`	2	--	ut3¹ nc-transcript-variantese³		13		NS EA NA WA	660

HapMap Linkage Disequilibrium report for ADIPOR1 (202909951 - 202927700 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for ADIPOR1: --
Human Gene Mutation Database (HGMD): ADIPOR1

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607945 OMIM disorders: --

Selected diseases for ADIPOR1 (see all 50): About MalaCards

nonalcoholic steatohepatitis anorexia nervosa insulin resistance fatty liver disease

morbid obesity gestational diabetes gastrointestinal stromal tumor coronary artery disease

chondrosarcoma chronic lymphocytic leukemia eclampsia liver disease

pre-eclampsia liver cirrhosis prader-willi syndrome chronic myeloid leukemia

1 disease from the University of Copenhagen DISEASES database for ADIPOR1:

Diabetes mellitus

ADIPOR1 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for ADIPOR1 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin sensitivity	74.8	19	19037660 (5), 17426101 (1), 17716299 (1), 18294218 (1) (see all 11)
insulin resistance	74.3	33	15918014 (4), 17216283 (3), 17712104 (3), 14759511 (2) (see all 20)
obesity	64.4	13	17607322 (3), 16756736 (2), 16493120 (1), 20357764 (1) (see all 9)
impaired glucose tolerance	40.8	3	16724230 (1), 17391161 (1), 17878241 (1)
diabetes gestational	37.8	2	16343040 (1), 16570162 (1)
anorexia nervosa	30.6	1	17391161 (1)
inflammation	16.7	1	16700915 (1)
cardiovascular diseases	15.5	1	16756736 (1)
breast cancer	8.87	25	17123704 (6), 18451143 (2), 19524379 (2), 18288417 (2) (see all 7)
necrosis	8.24	5	14759511 (1), 18988888 (1), 20470261 (1), 16899222 (1) (see all 5)

Genetic Association Database (GAD): ADIPOR1
Human Genome Epidemiology (HuGE) Navigator: ADIPOR1 (47 documents)

Export disorders for ADIPOR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADIPOR1 gene, integrated from 10 sources (see all 251):
(articles sorted by number of sources associating them with ADIPOR1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)^{1, 2, 3} Yamauchi T.... Kadowaki T. (Nature 2003)
Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. (PubMed id 16724230)^{1, 4, 9} Siitonen N....Uusitupa M. (Diabetologia 2006)
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)^{1, 4, 9} Stefan N....HAoring H.U. (Diabetologia 2005)
The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)^{1, 4, 9} Rasmussen-Torvik L.J....Sinaiko A.R. (Hum. Genet. 2009)
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. (PubMed id 17003341)^{1, 4, 9} Soccio T....Doria A. (Diabetes 2006)
Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans. (PubMed id 17712104)^{1, 4, 9} Crimmins N.A....Martin L.J. (Obesity (Silver Spring) 2007)
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)^{1, 4, 9} Hara K....Kadowaki T. (Diabetologia 2005)
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PubMed id 20032495)^{1, 4, 9} Ferguson J.F....Roche H.M. (Am. J. Clin. Nutr. 2010)
Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. (PubMed id 18827209)^{1, 4, 9} Kaklamani V.G....Pasche B. (JAMA 2008)
Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)^{1, 4, 9} Vaxillaire M....Froguel P. (Diabetes 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51094	HGNC: 24040	AceView: ADIPOR1	Ensembl:ENSG00000159346	euGenes: HUgn51094
ECgene: ADIPOR1	Kegg: 51094	H-InvDB: ADIPOR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADIPOR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADIPOR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADIPOR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADIPOR1 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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