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ADIPOR1 Gene(Protein Coding)

Adiponectin Receptor 1

GCID:
GC01M202940
GIFtS:
69
Genes Participants
UDN Logo

Aliases for ADIPOR1 Gene

Aliases for ADIPOR1 Gene

  • Adiponectin Receptor 1 2 3 5
  • Progestin And AdipoQ Receptor Family Member I 3 4
  • TESBP1A 3 4
  • PAQR1 3 4
  • ACDCR1 3
  • CGI-45 3
  • CGI45 3

External Ids for ADIPOR1 Gene

Previous GeneCards Identifiers for ADIPOR1 Gene

  • GC01M199376
  • GC01M200198
  • GC01M199641
  • GC01M201176
  • GC01M202909
  • GC01M174075

Summaries for ADIPOR1 Gene

Entrez Gene Summary for ADIPOR1 Gene

  • This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADIPOR1 Gene

ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include liver disease and gestational diabetes. Among its related pathways are Adipocytokine signaling pathway and AMPK signaling pathway. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.

UniProtKB/Swiss-Prot for ADIPOR1 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Gene Wiki entry for ADIPOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOR1 Gene

Genomics for ADIPOR1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADIPOR1 Gene

Enhancers for ADIPOR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Promoters for ADIPOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ADIPOR1 gene promoter:

Genomic Location for ADIPOR1 Gene

Chromosome:
1
Start:
202,940,823 bp from pter
End:
202,958,572 bp from pter
Size:
17,750 bases
Orientation:
Minus strand

Genomic View for ADIPOR1 Gene

Genes around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADIPOR1 Gene

Proteins for ADIPOR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADIPOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A54-ADR1_HUMAN
    Recommended name:
    Adiponectin receptor protein 1
    Protein Accession:
    Q96A54
    Secondary Accessions:
    • B3KMB0
    • Q53HS7
    • Q53YY6
    • Q9Y360

    Protein attributes for ADIPOR1 Gene

    Size:
    375 amino acids
    Molecular mass:
    42616 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR2.
    SequenceCaution:
    • Sequence=AAD34040.1; Type=Frameshift; Positions=369; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR1 Gene

neXtProt entry for ADIPOR1 Gene

Proteomics data for ADIPOR1 Gene at MOPED

Protein Expression for ADIPOR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADIPOR1 Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIPOR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ADIPOR1 Gene

Domains & Families for ADIPOR1 Gene

Gene Families for ADIPOR1 Gene

HGNC:
IUPHAR :

Protein Domains for ADIPOR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADIPOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A54

UniProtKB/Swiss-Prot:

ADR1_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR1: view

Function for ADIPOR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADIPOR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Gene Ontology (GO) - Molecular Function for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 19233263
GO:0055100 adiponectin binding IEA,IDA 12802337
GO:0097003 adipokinetic hormone receptor activity IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR1: view

Phenotypes for ADIPOR1 Gene

MGI mutant phenotypes for ADIPOR1:
inferred from 5 alleles
GenomeRNAi human phenotypes for ADIPOR1:
genes like me logo Genes that share phenotypes with ADIPOR1: view

Animal Models for ADIPOR1 Gene

MGI Knock Outs for ADIPOR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADIPOR1

CRISPR Products

miRNA for ADIPOR1 Gene

miRTarBase miRNAs that target ADIPOR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOR1 Gene

Localization for ADIPOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOR1 Gene COMPARTMENTS Subcellular localization image for ADIPOR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ADIPOR1: view

Pathways & Interactions for ADIPOR1 Gene

genes like me logo Genes that share pathways with ADIPOR1: view

SIGNOR curated interactions for ADIPOR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009755 hormone-mediated signaling pathway IDA 12802337
GO:0019395 fatty acid oxidation IDA 12802337
GO:0042593 glucose homeostasis IEA,ISS --
GO:0046427 positive regulation of JAK-STAT cascade IEA --
GO:0046628 positive regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADIPOR1: view

Drugs & Compounds for ADIPOR1 Gene

Products:

  1. Drug

(6) Drugs for ADIPOR1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AdipoRon Pharma 0

(7) Additional Compounds for ADIPOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADIPOR1 Gene

Compound Action Cas Number
AdipoRon 924416-43-3
genes like me logo Genes that share compounds with ADIPOR1: view

Drug Products

Transcripts for ADIPOR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADIPOR1 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(569) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADIPOR1 Gene

Adiponectin receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: - - -
SP11:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ADIPOR1 Gene

GeneLoc Exon Structure for
ADIPOR1
ECgene alternative splicing isoforms for
ADIPOR1

Expression for ADIPOR1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ADIPOR1 Gene

mRNA expression in normal human tissues for ADIPOR1 Gene
mRNA expression by BioGPS for ADIPOR1 GenemRNA expression by GTEx for ADIPOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIPOR1 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for ADIPOR1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADIPOR1 Gene



SOURCE GeneReport for Unigene cluster for ADIPOR1 Gene Hs.713729

mRNA Expression by UniProt/SwissProt for ADIPOR1 Gene

Q96A54-ADR1_HUMAN
Tissue specificity: Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
genes like me logo Genes that share expression patterns with ADIPOR1: view

Protein tissue co-expression partners for ADIPOR1 Gene

- Elite partner

Primer Products

Orthologs for ADIPOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ADIPOR1 35
  • 87.64 (n)
  • 96.8 (a)
ADIPOR1 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ADIPOR1 35
  • 95.47 (n)
  • 98.93 (a)
ADIPOR1 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Adipor1 35
  • 90.93 (n)
  • 96.8 (a)
Adipor1 16
Adipor1 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ADIPOR1 35
  • 99.56 (n)
  • 100 (a)
ADIPOR1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Adipor1 35
  • 91.82 (n)
  • 97.6 (a)
oppossum
(Monodelphis domestica)
 Mammalia ADIPOR1 36
  • 96 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ADIPOR1 36
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ADIPOR1 35
  • 80.12 (n)
  • 91.44 (a)
ADIPOR1 36
  • 92 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ADIPOR1 36
  • 92 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia adipor1 35
  • 76.64 (n)
  • 89.2 (a)
Str.15110 35
African clawed frog
(Xenopus laevis)
 Amphibia adipor1-prov 35
zebrafish
(Danio rerio)
 Actinopterygii adipor1b 35
  • 73.2 (n)
  • 82.91 (a)
Dr.4053 35
adipor1a 36
  • 82 (a)
 OneToMany
adipor1b 36
  • 79 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG5315 35
  • 58.38 (n)
  • 56.67 (a)
CG5315 36
  • 44 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea paqr-1 35
  • 58.73 (n)
  • 57.14 (a)
paqr-1 36
  • 40 (a)
 ManyToMany
paqr-2 36
  • 29 (a)
 ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ACL002C 35
  • 45.91 (n)
  • 38.13 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D01331g 35
  • 45.05 (n)
  • 38.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes IZH2 35
  • 44.9 (n)
  • 37.31 (a)
IZH1 36
  • 30 (a)
 ManyToMany
IZH2 36
  • 34 (a)
 ManyToMany
IZH3 38
rice
(Oryza sativa)
 Liliopsida Os12g0511200 35
  • 48.44 (n)
  • 39.7 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4089 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU04987 35
  • 47.33 (n)
  • 38 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPBC12C2.09c 35
  • 47.88 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8140 36
  • 51 (a)
 OneToMany
Species with no ortholog for ADIPOR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADIPOR1 Gene

ENSEMBL:
Gene Tree for ADIPOR1 (if available)
TreeFam:
Gene Tree for ADIPOR1 (if available)

Paralogs for ADIPOR1 Gene

Paralogs for ADIPOR1 Gene

(2) SIMAP similar genes for ADIPOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADIPOR1 Gene

genes like me logo Genes that share paralogs with ADIPOR1: view

Variants for ADIPOR1 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8167 -- 202,941,059(+) AAGCC(A/C/G/T)CCAAC utr-variant-3-prime
rs10581 -- 202,941,190(-) ACCCC(C/T)ATCCT utr-variant-3-prime
rs1043213 -- 202,946,476(-) CGCAT(C/T)CATAC reference, synonymous-codon
rs1043268 -- 202,941,138(-) AGCAC(A/C)CTTTT utr-variant-3-prime
rs1043280 -- 202,941,100(-) TCTTT(C/T)TAGGG utr-variant-3-prime

Variation tolerance for ADIPOR1 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIPOR1 Gene

HapMap Linkage Disequilibrium report
ADIPOR1
Human Gene Mutation Database (HGMD)
ADIPOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADIPOR1 Gene

Disorders for ADIPOR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADIPOR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
liver disease
  • disorder of liver
gestational diabetes
  • gdm
fatty liver disease
  • alcoholic fatty liver
obesity
  • obesity, association with
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADIPOR1

Genetic Association Database (GAD)
ADIPOR1
Human Genome Epidemiology (HuGE) Navigator
ADIPOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIPOR1
genes like me logo Genes that share disorders with ADIPOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR1 Gene

Publications for ADIPOR1 Gene

  1. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PMID: 12802337) Yamauchi T. … Kadowaki T. (Nature 2003) 2 3 4 67
  2. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson J.F. … Roche H.M. (Am. J. Clin. Nutr. 2010) 3 23
  3. ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. (PMID: 20074551) Charlton H.K. … Whitehead J.P. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans. (PMID: 20125105) Felder T.K. … Patsch W. (Int J Obes (Lond) 2010) 3 23
  5. Dimerization of adiponectin receptor 1 is inhibited by adiponectin. (PMID: 20332107) Kosel D. … Beck-Sickinger A.G. (J. Cell. Sci. 2010) 3 23

Products for ADIPOR1 Gene

Sources for ADIPOR1 Gene

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