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ADIPOR1 Gene

protein-coding   GIFtS: 61
GCID: GC01M202909

Adiponectin Receptor 1

  See ADIPOR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adiponectin Receptor 11 2     CGI452 5
Progestin And AdipoQ Receptor Family Member I2 3     ACDCR12
PAQR12 3     Adiponectin Receptor Protein 12
TESBP1A2 3     

External Ids:    HGNC: 240401   Entrez Gene: 510942   Ensembl: ENSG000001593467   OMIM: 6079455   UniProtKB: Q96A543   

Export aliases for ADIPOR1 gene to outside databases

Previous GC identifers: GC01M199376 GC01M200198 GC01M199641 GC01M201176 GC01M174075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADIPOR1 Gene:
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which
regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in
activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin
sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Mar 2014)

GeneCards Summary for ADIPOR1 Gene:
ADIPOR1 (adiponectin receptor 1) is a protein-coding gene. Diseases associated with ADIPOR1 include nonalcoholic steatohepatitis, and insulin resistance. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is PAQR4.

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length
adiponectin

Gene Wiki entry for ADIPOR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ADIPOR1 gene promoter:
         CREB   deltaCREB   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADIPOR1 promoter sequence
   Search Chromatin IP Primers for ADIPOR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIPOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202909:  view genomic region     (about GC identifiers)

Start:
202,909,951 bp from pter      End:
202,927,700 bp from pter
Size:
17,750 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 (See protein sequence)
Recommended Name: Adiponectin receptor protein 1  
Size: 375 amino acids; 42616 Da
Subunit: May form homomultimer and heteromultimers
Sequence caution: Sequence=AAD34040.1; Type=Frameshift; Positions=369;
Secondary accessions: B3KMB0 Q53HS7 Q53YY6 Q9Y360

Explore the universe of human proteins at neXtProt for ADIPOR1: NX_Q96A54

Explore proteomics data for ADIPOR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86
  • Modification sites at PhosphoSitePlus

  • See ADIPOR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001277482.1  NP_001277486.1  NP_001277558.1  NP_057083.2  

    ENSEMBL proteins: 
     ENSP00000341785   ENSP00000402178   ENSP00000392946   ENSP00000395469   ENSP00000356223  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADIPOR: GPCR / Unclassified : Adiponectin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Adipo1 receptor
    Adiponectin receptors

    1 InterPro protein domain:
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q96A54

    ProtoNet protein and cluster: Q96A54

    1 Blocks protein domain: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
    Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular
    Similarity: Belongs to the ADIPOR family


    Find genes that share domains with ADIPOR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADR1_HUMAN, Q96A54
    Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
    that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
    fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
    adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length
    adiponectin

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IBA--
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IPI19233263
    GO:0042562hormone binding IDA12802337
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with ADIPOR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADIPOR1:
     Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adipor1):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     liver/biliary system  muscle  normal  skeleton 

    Find genes that share phenotypes with ADIPOR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adipor1tm1Tka for ADIPOR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADIPOR1
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    hsa-mir-197-3p (MIRT048047)

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    hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidADIPOR1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADR1_HUMAN, Q96A54: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular
    organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19233263
    GO:0016021integral component of membrane NAS12802337

    Find genes that share ontologies with ADIPOR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADIPOR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2AMPK signaling
    AMPK signaling
    3Adipocytokine signaling pathway
    Adipocytokine signaling pathway


    Find genes that share SuperPaths with ADIPOR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADIPOR1
        AMPK signaling



    2 Kegg Pathways  (Kegg details for ADIPOR1):
        Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOR1: 
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Fatty Liver in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADIPOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ADIPOR1 (Q96A541, 3 ENSP000003417854) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG11, 3, ENSP000002882664EBI-1632076,EBI-741243 I2D: score=2 STRING: ENSP00000288266
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    APPL2Q8NEU83, ENSP000002585304I2D: score=1 STRING: ENSP00000258530
    ADIPOR1Q96A541EBI-1632076,EBI-1632076
    ADIPOQENSP000003207094STRING: ENSP00000320709
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009755hormone-mediated signaling pathway IDA12802337
    GO:0019395fatty acid oxidation IDA12802337
    GO:0030308negative regulation of cell growth IEA--
    GO:0033210leptin-mediated signaling pathway IEA--
    GO:0033211adiponectin-activated signaling pathway IBA--

    Find genes that share ontologies with ADIPOR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADIPOR1 (ADR1)

    Selected Novoseek inferred chemical compound relationships for ADIPOR1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 52.6 25 17426101 (2), 18294218 (2), 17878241 (2), 17285539 (2) (see all 15)
    fatty acid 50.4 9 20032495 (2), 16603155 (1), 17786081 (1), 16055297 (1) (see all 8)
    pioglitazone 43.5 6 16023994 (1), 19169664 (1)
    c-peptide 42.8 1 15331527 (1)
    lipid 33.5 7 20032495 (1), 16023994 (1), 18288417 (1), 16756736 (1) (see all 6)
    rosiglitazone 18.1 6 15991021 (4), 15824748 (1)
    p002 5.68 2 15991021 (1)
    p003 3.48 1 15105989 (1)
    cholesterol 0 1 15331527 (1)
    steroid 0 2 19453184 (1), 19671624 (1)



    Find genes that share compounds with ADIPOR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADIPOR1 gene (4 alternative transcripts): 
    NM_001290553.1  NM_001290557.1  NM_001290629.1  NM_015999.5  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340990(uc010pqd.2 uc001gyq.4 uc001gyr.4) ENST00000495562
    ENST00000417068 ENST00000426229 ENST00000436244(uc001gys.4) ENST00000367254

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    hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidADIPOR1 3' UTR sequence
    Inhib. RNA
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    Selected AceView cDNA sequences (see all 569):

    CK823852 BX105151 BX448414 BM788473 CR609684 CR596678 BM783093 BX349860 
    BC010743 CR596346 BI917225 BM470119 BM783069 AU123343 CB133926 BG283299 
    AI220633 AI700668 CR608908 BC001594 CR610540 CA489803 AW752990 AU099335 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
    SP1:                          -     -     -     -                 -                                                           -                                 
    SP2:        -     -     -     -     -     -                       -                                                                                             
    SP3:                          -     -     -                       -                                                                                             
    SP4:                                -     -                       -                                                                                             
    SP5:                          -     -     -     -           -     -     -     -     -     -     -                             -                                 

    ExUns: 13b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ADIPOR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADIPOR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTGTGTC
    ADIPOR1 Expression
    About this image


    ADIPOR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Pancreas (Endocrine System)
    ADIPOR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADIPOR1 Protein Expression

    UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
    Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in
    brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon,
    thymus and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOR1: 
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Fatty Liver in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADIPOR1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adipor11 , 5 adiponectin receptor 11, 5 90.93(n)1
    96.8(a)1
      1 (58.22 cM)5
    726741  NM_028320.31  NP_082596.21 
     1344153785 
    chicken
    (Gallus gallus)
    Aves ADIPOR11 adiponectin receptor 1 80.12(n)
    91.44(a)
      421148  NM_001031027.1  NP_001026198.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADIPOR16
    adiponectin receptor 1
    92(a)
    1 ↔ 1
    GL344118.1(30058-52076)
    African clawed frog
    (Xenopus laevis)
    Amphibia adipor1-prov2 adiponectin receptor 1 78.92(n)    BC044035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.40532 Danio rerio mRNA similar to RIKEN cDNA 2810031L11 gene more 77.67(n)    BC044388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53151 CG5315 58.38(n)
    56.67(a)
      42656  NM_170020.2  NP_732759.2 
    worm
    (Caenorhabditis elegans)
    Secernentea paqr-11 paqr-1 58.73(n)
    57.14(a)
      177416  NM_068597.5  NP_500998.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IZH3(YLR023C)4
    IZH21
    Membrane protein involved in zinc ion homeostasis, more4
    IZH21
    44.9(n)1
    37.31(a)1
      12(187129-185498)4
    8541601  NP_014641.21  8507104 
     NP_013123.14 
    rice
    (Oryza sativa)
    Liliopsida Os12g05112001 Os12g0511200 48.44(n)
    39.7(a)
      4352324  NM_001073399.1  NP_001066867.1 


    ENSEMBL Gene Tree for ADIPOR1 (if available)
    TreeFam Gene Tree for ADIPOR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADIPOR1 gene
    PAQR42  PAQR32  ADIPOR22  
    2 SIMAP similar genes for ADIPOR1 using alignment to 4 protein entries:     ADR1_HUMAN (see all proteins):
    ADIPOR2    PAQR3

    Find genes that share paralogs with ADIPOR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ADIPOR1
    PGOHUM00000248258


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADIPOR1 (see all 442)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861281951,2
    --202909460(+) TTACCC/TTCCCG 2 -- int10--------
    rs2003770971,2
    --202909493(+) ACCAC-/CACACGA 2 -- int10--------
    rs665136231,2
    C--202909497(+) CCACG-/ATAGGCT 2 -- int10--------
    rs773460031,2
    C--202909593(+) CTCAGA/TCTCCC 2 -- int10--------
    rs64279811,2
    C,F,A--202909603(+) CAAAGT/CGTTGG 2 -- int15Minor allele frequency- C:0.20NA 10
    rs1121576161,2
    C,F--202909619(+) CAGGCG/ATGAGC 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs783377241,2
    C,F--202909662(+) TTGAAC/TACTAC 2 -- int13Minor allele frequency- T:0.12WA NA EA 358
    rs1389704871,2
    C--202909693(+) AACAAA/GATGGT 2 -- int10--------
    rs569346001,2
    C,F--202909737(+) AATTTA/TAAAAT 2 -- int16Minor allele frequency- T:0.27WA NA CSA EA 363
    rs75395421,2
    C,F,A,H--202909974(+) CAAGTG/CTCTTC 2 -- ut31 nc-transcript-variantese313Minor allele frequency- C:0.40NS EA NA WA 660

    HapMap Linkage Disequilibrium report for ADIPOR1 (202909951 - 202927700 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADIPOR1: --
    Human Gene Mutation Database (HGMD): ADIPOR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADIPOR1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADIPOR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607945    OMIM disorders: --

    4 diseases for ADIPOR1:    
    About MalaCards
    nonalcoholic steatohepatitis    insulin resistance    coronary artery disease    obesity

    1 disease from the University of Copenhagen DISEASES database for ADIPOR1:
    Diabetes mellitus

    Find genes that share disorders with ADIPOR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADIPOR1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 74.8 19 19037660 (5), 17426101 (1), 17716299 (1), 18294218 (1) (see all 11)
    insulin resistance 74.3 33 15918014 (4), 17216283 (3), 17712104 (3), 14759511 (2) (see all 20)
    obesity 64.4 13 17607322 (3), 16756736 (2), 16493120 (1), 20357764 (1) (see all 9)
    impaired glucose tolerance 40.8 3 16724230 (1), 17391161 (1), 17878241 (1)
    diabetes gestational 37.8 2 16343040 (1), 16570162 (1)
    anorexia nervosa 30.6 1 17391161 (1)
    inflammation 16.7 1 16700915 (1)
    cardiovascular diseases 15.5 1 16756736 (1)
    breast cancer 8.87 25 17123704 (6), 18451143 (2), 19524379 (2), 18288417 (2) (see all 7)
    necrosis 8.24 5 14759511 (1), 18988888 (1), 20470261 (1), 16899222 (1) (see all 5)

    Genetic Association Database (GAD): ADIPOR1
    Human Genome Epidemiology (HuGE) Navigator: ADIPOR1 (47 documents)

    Export disorders for ADIPOR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADIPOR1 gene, integrated from 10 sources (see all 251):
    (articles sorted by number of sources associating them with ADIPOR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)1, 2, 3 Yamauchi T.... Kadowaki T. (Nature 2003)
    2. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. (PubMed id 16724230)1, 4, 9 Siitonen N....Uusitupa M. (Diabetologia 2006)
    3. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)1, 4, 9 Stefan N....HAoring H.U. (Diabetologia 2005)
    4. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)1, 4, 9 Rasmussen-Torvik L.J....Sinaiko A.R. (Hum. Genet. 2009)
    5. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. (PubMed id 17003341)1, 4, 9 Soccio T....Doria A. (Diabetes 2006)
    6. Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans. (PubMed id 17712104)1, 4, 9 Crimmins N.A....Martin L.J. (Obesity (Silver Spring) 2007)
    7. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)1, 4, 9 Hara K....Kadowaki T. (Diabetologia 2005)
    8. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PubMed id 20032495)1, 4, 9 Ferguson J.F....Roche H.M. (Am. J. Clin. Nutr. 2010)
    9. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. (PubMed id 18827209)1, 4, 9 Kaklamani V.G....Pasche B. (JAMA 2008)
    10. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)1, 4, 9 Vaxillaire M....Froguel P. (Diabetes 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51094 HGNC: 24040 AceView: ADIPOR1 Ensembl:ENSG00000159346 euGenes: HUgn51094
    ECgene: ADIPOR1 Kegg: 51094 H-InvDB: ADIPOR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADIPOR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADIPOR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADIPOR1 gene:
    Search GeneIP for patents involving ADIPOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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