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Aliases for ADIPOR1 Gene

Aliases for ADIPOR1 Gene

  • Adiponectin Receptor 1 2 3 5
  • Progestin And AdipoQ Receptor Family Member I 3 4
  • TESBP1A 3 4
  • PAQR1 3 4
  • Adiponectin Receptor Protein 1 3
  • ACDCR1 3
  • CGI-45 3
  • CGI45 3

External Ids for ADIPOR1 Gene

Previous GeneCards Identifiers for ADIPOR1 Gene

  • GC01M199376
  • GC01M200198
  • GC01M199641
  • GC01M201176
  • GC01M202909
  • GC01M174075

Summaries for ADIPOR1 Gene

Entrez Gene Summary for ADIPOR1 Gene

  • This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADIPOR1 Gene

ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include Fatty Liver Disease and Gestational Diabetes. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.

UniProtKB/Swiss-Prot for ADIPOR1 Gene

  • Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Gene Wiki entry for ADIPOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOR1 Gene

Genomics for ADIPOR1 Gene

Regulatory Elements for ADIPOR1 Gene

Enhancers for ADIPOR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F202856 1.4 Ensembl ENCODE 16.1 +99.1 99073 5.6 ZFP64 ARID4B SIN3A DMAP1 YY1 FOS ZNF263 SP3 SP5 NFYC ZBED6 RNPEP ENSG00000273478 LOC100506672 HNRNPA1P59 LOC102723465 LOC730222 ADIPOR1 RABIF PCAT6
GH01F202956 0.5 ENCODE 12 -1.1 -1111 6.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ZBED6 RNPEP ENSG00000273478 ADIPOR1 HNRNPA1P59 PRELP LOC100506672 SNRPE CYB5R1 LOC100506747
GH01F202988 0.8 Ensembl 10.9 -29.8 -29829 0.8 HDGF HDAC1 ATF1 CREB3L1 SREBF2 SIN3A ZNF2 ZBTB40 RARA ZNF335 CYB5R1 ADIPOR1 KDM5B PCAT6 ENSG00000232626 GC01M202941 RPS20P8
GH01F202963 1.2 FANTOM5 ENCODE 10.8 -8.1 -8083 6.6 HDGF ATF1 PKNOX1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF48 ZNF121 CYB5R1 BTG2 KLHL12 LOC100506747 ADIPOR1 KDM5B PCAT6 LOC148709 LOC730222 RABIF
GH01F202951 1 Ensembl ENCODE 9.4 +4.8 4772 4.0 MAX ZNF644 ZNF664 ZNF316 ZBTB48 ZBTB33 ZNF24 SP7 KLHL12 LOC100506747 KDM5B PCAT6 ADIPOR1 CYB5R1 GC01P202952
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Promoters for ADIPOR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288390 672 1801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for ADIPOR1 Gene

Chromosome:
1
Start:
202,940,823 bp from pter
End:
202,958,572 bp from pter
Size:
17,750 bases
Orientation:
Minus strand

Genomic View for ADIPOR1 Gene

Genes around ADIPOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR1 Gene

Proteins for ADIPOR1 Gene

  • Protein details for ADIPOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A54-ADR1_HUMAN
    Recommended name:
    Adiponectin receptor protein 1
    Protein Accession:
    Q96A54
    Secondary Accessions:
    • B3KMB0
    • Q53HS7
    • Q53YY6
    • Q9Y360

    Protein attributes for ADIPOR1 Gene

    Size:
    375 amino acids
    Molecular mass:
    42616 Da
    Quaternary structure:
    • May form homooligomers and heterooligomers with ADIPOR2.
    SequenceCaution:
    • Sequence=AAD34040.1; Type=Frameshift; Positions=369; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADIPOR1 Gene

neXtProt entry for ADIPOR1 Gene

Post-translational modifications for ADIPOR1 Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIPOR1 Gene

No data available for DME Specific Peptides for ADIPOR1 Gene

Domains & Families for ADIPOR1 Gene

Protein Domains for ADIPOR1 Gene

Suggested Antigen Peptide Sequences for ADIPOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A54

UniProtKB/Swiss-Prot:

ADR1_HUMAN :
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
  • Belongs to the ADIPOR family.
Domain:
  • The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Family:
  • Belongs to the ADIPOR family.
genes like me logo Genes that share domains with ADIPOR1: view

Function for ADIPOR1 Gene

Molecular function for ADIPOR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Gene Ontology (GO) - Molecular Function for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 19233263
GO:0042802 identical protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
GO:0055100 adiponectin binding IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR1: view
genes like me logo Genes that share phenotypes with ADIPOR1: view

Animal Models for ADIPOR1 Gene

MGI Knock Outs for ADIPOR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADIPOR1

miRNA for ADIPOR1 Gene

miRTarBase miRNAs that target ADIPOR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOR1 Gene

Localization for ADIPOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269 PubMed:12802337}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOR1 Gene COMPARTMENTS Subcellular localization image for ADIPOR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 19233263
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 12802337
genes like me logo Genes that share ontologies with ADIPOR1: view

Pathways & Interactions for ADIPOR1 Gene

genes like me logo Genes that share pathways with ADIPOR1: view

SIGNOR curated interactions for ADIPOR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009755 hormone-mediated signaling pathway IDA 12802337
GO:0010633 negative regulation of epithelial cell migration IMP 23776679
genes like me logo Genes that share ontologies with ADIPOR1: view

Drugs & Compounds for ADIPOR1 Gene

(7) Drugs for ADIPOR1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AdipoRon Pharma 0

(6) Additional Compounds for ADIPOR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADIPOR1 Gene

Compound Action Cas Number
AdipoRon 924416-43-3
genes like me logo Genes that share compounds with ADIPOR1: view

Drug Products

Transcripts for ADIPOR1 Gene

Unigene Clusters for ADIPOR1 Gene

Adiponectin receptor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: - - -
SP11:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ADIPOR1 Gene

GeneLoc Exon Structure for
ADIPOR1
ECgene alternative splicing isoforms for
ADIPOR1

Expression for ADIPOR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADIPOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIPOR1 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for ADIPOR1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADIPOR1 Gene



Protein tissue co-expression partners for ADIPOR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADIPOR1 Gene:

ADIPOR1

SOURCE GeneReport for Unigene cluster for ADIPOR1 Gene:

Hs.713729

mRNA Expression by UniProt/SwissProt for ADIPOR1 Gene:

Q96A54-ADR1_HUMAN
Tissue specificity: Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
genes like me logo Genes that share expression patterns with ADIPOR1: view

Primer Products

Orthologs for ADIPOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOR1 34 35
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia ADIPOR1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIPOR1 34 35
  • 95.47 (n)
rat
(Rattus norvegicus)
Mammalia Adipor1 34
  • 91.82 (n)
mouse
(Mus musculus)
Mammalia Adipor1 34 16 35
  • 90.93 (n)
cow
(Bos Taurus)
Mammalia ADIPOR1 34 35
  • 87.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADIPOR1 34 35
  • 80.12 (n)
lizard
(Anolis carolinensis)
Reptilia ADIPOR1 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adipor1 34
  • 76.64 (n)
Str.15110 34
African clawed frog
(Xenopus laevis)
Amphibia adipor1-prov 34
zebrafish
(Danio rerio)
Actinopterygii adipor1a 35
  • 82 (a)
OneToMany
adipor1b 34 35
  • 73.2 (n)
Dr.4053 34
fruit fly
(Drosophila melanogaster)
Insecta CG5315 34 35
  • 58.38 (n)
worm
(Caenorhabditis elegans)
Secernentea paqr-1 34 35
  • 58.73 (n)
paqr-2 35
  • 29 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL002C 34
  • 45.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01331g 34
  • 45.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH2 34 35
  • 44.9 (n)
IZH1 35
  • 30 (a)
ManyToMany
IZH3 37
rice
(Oryza sativa)
Liliopsida Os12g0511200 34
  • 48.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8140 35
  • 51 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.09c 34
  • 47.88 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04987 34
  • 47.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4089 34
Species where no ortholog for ADIPOR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADIPOR1 Gene

ENSEMBL:
Gene Tree for ADIPOR1 (if available)
TreeFam:
Gene Tree for ADIPOR1 (if available)

Paralogs for ADIPOR1 Gene

Paralogs for ADIPOR1 Gene

(2) SIMAP similar genes for ADIPOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADIPOR1 Gene

genes like me logo Genes that share paralogs with ADIPOR1: view

Variants for ADIPOR1 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1043213 -- 202,946,476(-) CGCAT(C/T)CATAC reference, synonymous-codon, utr-variant-5-prime
rs1043268 -- 202,941,138(-) AGCAC(A/C)CTTTT utr-variant-3-prime
rs1043280 -- 202,941,100(-) TCTTT(C/T)TAGGG utr-variant-3-prime
rs10494839 -- 202,953,066(+) AACAA(C/T)TGAGC intron-variant
rs10581 -- 202,941,190(-) ACCCC(C/T)ATCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADIPOR1 Gene

Variant ID Type Subtype PubMed ID
nsv1068426 CNV deletion 25765185

Variation tolerance for ADIPOR1 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIPOR1 Gene

Human Gene Mutation Database (HGMD)
ADIPOR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIPOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Disorders for ADIPOR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADIPOR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
gestational diabetes
  • gdm
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
obesity
  • obesity, association with
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADIPOR1

Genetic Association Database (GAD)
ADIPOR1
Human Genome Epidemiology (HuGE) Navigator
ADIPOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIPOR1
genes like me logo Genes that share disorders with ADIPOR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADIPOR1 Gene

Publications for ADIPOR1 Gene

  1. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson J.F. … Roche H.M. (Am. J. Clin. Nutr. 2010) 3 22 46 64
  2. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PMID: 19037660) Rasmussen-Torvik L.J. … Sinaiko A.R. (Hum. Genet. 2009) 3 22 46 64
  3. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PMID: 19208777) Kotronen A. … Fisher R.M. (Eur. J. Endocrinol. 2009) 3 22 46 64
  4. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. (PMID: 19723917) Teras L.R. … Feigelson H.S. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 22 46 64
  5. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. (PMID: 18294218) Ruchat S.M. … PAcrusse L. (Diabet. Med. 2008) 3 22 46 64

Products for ADIPOR1 Gene

Sources for ADIPOR1 Gene

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