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Aliases & Descriptions for ADIPOR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ACDCR1 1 , 2 CGI-45 2 CGI45 2 , 5 FLJ25385 2 FLJ42464 2 OTTHUMP00000038805 2 PAQR1 1 , 2 , 3 TESBP1A 2
Descriptions Progestin and adipoQ receptor family member I 3 adiponectin receptor 1 2
Search outside databases for aliases for ADIPOR1 genePrevious GC identifers: GC01M199376 GC01M200198 GC01M199641
Summaries for ADIPOR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ADIPOR1 : The adiponectin receptors, ADIPOR1 and ADIPOR2 (MIM 607946), serve as receptors for globular andfull-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha(PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake byadiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM] UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 Function : Receptor for globular and full-length adiponectin (APM1), an essential hormone secretedby adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulatelipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity,fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor forglobular adiponectin but low-affinity receptor for full-length adiponectin
Gene Wiki entry for ADIPOR1
Genomic Location for ADIPOR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ADIPOR1 gene Entrez Gene cytogenetic band: 1p36.13-q41 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1 ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M201176:
(about GC identifiers )
Start:
201,176,576 bp from pter
End:
201,194,040 bp from pter
Size:
17,465 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for ADIPOR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 (See
protein sequence )Recommended Name: Adiponectin receptor protein 1 Size : 375 amino acids; 42616 Da
Subunit : May form homo and heteromultimers
Subcellular location : Membrane; Multi-pass membrane protein. Note=Localized to the cell membraneand intracellular organelles
Sequence caution : Sequence=AAD34040.1; Type=Frameshift; Positions=369;
Secondary accessions : Q9Y360
REFSEQ proteins (2 alternative transcripts):
NP_001121159.1 NP_057083.2 ENSEMBL proteins: ENSP00000341785 ENSP00000356223 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ADIPOR1: Assays for ADIPOR1:
Protein
Domains/ Families for ADIPOR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96A54 ProtoNet protein and cluster: Q96A54
1 Blocks protein family : IPB004254 Hly-III related proteins UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 Similarity : Belongs to the ADIPOR family
Gene Function for ADIPOR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_015999 Applied Biosystems Silencer ® siRNAs for ADIPOR1 Sigma-Aldrich siRNA and siRNA Panels for ADIPOR1 Sigma-Aldrich shRNA for ADIPOR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015999 UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 Function : Receptor for globular and full-length adiponectin (APM1), an essential hormone secretedby adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulatelipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity,fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor forglobular adiponectin but low-affinity receptor for full-length adiponectin
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adipor1) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ADIPOR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADIPOR1 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for ADIPOR1 5/17 Interacting proteins for ADIPOR1 (ENSP00000356223 3 Q96A54 1 ) via UniProtKB, MINT, and/or STRING (see all 17
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for ADIPOR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ADIPOR1 8 Novoseek chemical compound relationships for ADIPOR1 gene
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Transcripts for ADIPOR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_015999 Sigma-Aldrich siRNA and siRNA Panels for ADIPOR1 Sigma-Aldrich shRNA for ADIPOR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001127687 NM_015999
REFSEQ mRNAs for ADIPOR1 gene (2 alternative transcripts): NM_001127687.1 NM_015999.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001127687 NM_015999
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001127687  
Additional cDNA sequence: AF125179.1 AF125180.1 AF151803.1 AK001484.1 AK058114.1 AK124455.1 AK222503.1 AY424279.1 BC001594.2 BC010743.1 CR590124.1 CR593948.1 CR596346.1 CR596678.1 CR597679.1 CR598544.1 CR599027.1 CR599130.1 CR601546.1 CR608908.1 CR609684.1 CR610443.1 CR610540.1 CR619012.1 CR625005.1 CR626149.1
24/26 DOTS entries (see all 26
): DT.91764040 DT.100887669 DT.91764021 DT.102829862 DT.121345272 DT.99953287 DT.100887661 DT.100676782 DT.100887654 DT.91764014 DT.97766849 DT.100887665 DT.91764038 DT.100887653 DT.100887662 DT.100887666 DT.100887668 DT.120757392 DT.121345310 DT.121345332 DT.91764023 DT.92032781 DT.95169465 DT.95169474
24/569 AceView cDNA sequences (see all 569
):BQ720130 BC010743 AI955276 BP375687 BF593983 BP351827 AI300305 CR599027 BF592056 BG683091 AA890343 BP334655 BF724883 CR625005 CR609684 CR598544 BE858834 BX461217 BQ223992 BM788473 CR596678 BX448414 CR619012 AI207172
highest scoring ESTs for ADIPOR1 :AA216518 AA725071 AA853335 AF151803 AK001484 AK058114 AL121534 AL546625 AU099335 AU126667
Unigene Cluster for ADIPOR1: Adiponectin receptor 1 Hs.5298 [show with all ESTs ] Unigene Representative Sequence: NM_015999 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 (see all 11
) ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · SP1 :         -   -   -   -       -                     -             SP2 :   -   -   -   -   -   -         -                                 SP3 :         -   -   -         -                                 SP4 :           -   -         -                                 SP5 :         -   -   -   -     -   -   -   -   -   -   -           -            
About this scheme ECgene alternative splicing isoforms for ADIPOR1 2 Ensembl transcripts including schematic representations : ENST00000340990
ENST00000367254
Expression for ADIPOR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ADIPOR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ADIPOR1 1 / 2 / 3
3 probe-sets matching ADIPOR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAAGTGTGTCSOURCE GeneReport for Unigene cluster: Hs.5298 UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 Tissue specificity : Widely expressed. Highly expressed in skeletal muscle. Expressed atintermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral bloodleukocytes. Weakly expressed in colon, thymus and small intestine
Orthologs for ADIPOR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ADIPOR1 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for ADIPOR1 ENSEMBL Gene Tree for ADIPOR1 Paralogs for ADIPOR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ADIPOR1 gene PAQR4 2 PAQR3 2 ADIPOR2 2 Pseudogenes 1 related pseudogene
SNPs/Variants for ADIPOR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ADIPOR1 (up to first 250kb)
Disorders & Mutations for ADIPOR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607945 10/12 Novoseek disease relationships for ADIPOR1 gene (see all 12
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
insulin sensitivity
74.23
18
19037660 (5), 17426101 (1), 17716299 (1), 19169664 (1) (see all 10 )
insulin resistance
73.15
29
15918014 (4), 17216283 (3), 17712104 (3), 14759511 (2) (see all 18 )
obesity
62.12
12
17607322 (3), 16756736 (2), 16493120 (1), 17391161 (1) (see all 8 )
impaired glucose tolerance
44.87
3
16724230 (1), 17391161 (1), 17878241 (1)
anorexia nervosa
34.76
1
17391161 (1)
inflammation
17.84
1
16700915 (1)
cardiovascular diseases
17.44
1
16756736 (1)
diabetes gestational
15.05
2
16343040 (1), 16570162 (1)
necrosis
6.51
4
14759511 (1), 18988888 (1), 16899222 (1), 15705753 (1)
breast cancer
0.00
20
17123704 (6), 18451143 (2), 18288417 (2), 18163210 (2)
About this table Human Gene Mutation Database : ADIPOR1 Genetic Association Database: ADIPOR1 Human Genome Epidemiology Navigator: ADIPOR1 (27 documents)
Medical News for ADIPOR1 (Possibly Related Articles in
Doctor's Guide )
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Publications for ADIPOR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/145 PubMed articles for ADIPOR1 gene (see all 145
): Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337) 2, 3, 4 Yamauchi T.... Kadowaki T. (2003) Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883) 1, 3, 6 Stefan N....Haring H.U. (2005) Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014) 1, 3, 6 Hara K....Kadowaki T. (2005) Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. (PubMed id 15983228) 1, 3, 6 Damcott C.M....Shuldiner A.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093) 3, 4 Lai C.H....Lin W. (2000) Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. (PubMed id 18982021) 1, 3 Ding Q....Chen Y. (2009) Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. (PubMed id 16724230) 1, 3 Siitonen N....Uusitupa M. (2006) Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. (PubMed id 16023994) 1, 3 Neumeier M....Buechler C. (2005) The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660) 1, 3 Rasmussen-Torvik L.J....Sinaiko A.R. (2009)
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Genome Databases showing ADIPOR1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ADIPOR1
(According to HUGE )
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--
Specialized Databases showing ADIPOR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ADIPOR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ADIPOR1:
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Medical News for ADIPOR1
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009