Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADIPOR1 Gene

protein-coding   GIFtS: 62
GCID: GC01M202909

Adiponectin Receptor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adiponectin Receptor 11 2     CGI452 5
Progestin And AdipoQ Receptor Family Member I2 3     ACDCR12
PAQR12 3     Adiponectin Receptor Protein 12
TESBP1A2 3     

External Ids:    HGNC: 240401   Entrez Gene: 510942   Ensembl: ENSG000001593467   OMIM: 6079455   UniProtKB: Q96A543   

Export aliases for ADIPOR1 gene to outside databases

Previous GC identifers: GC01M199376 GC01M200198 GC01M199641 GC01M201176 GC01M174075


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADIPOR1 Gene:
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which
regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in
activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin
sensitivity. A pseudogene of this gene is located on chromosome 14. (provided by RefSeq, Jan 2012)

GeneCards Summary for ADIPOR1 Gene: 
ADIPOR1 (adiponectin receptor 1) is a protein-coding gene. Diseases associated with ADIPOR1 include nonalcoholic steatohepatitis, and insulin resistance, and among its related super-pathways are Respiratory electron transport. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity. An important paralog of this gene is PAQR4.

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length
adiponectin

Gene Wiki entry for ADIPOR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADIPOR1 gene promoter:
         CREB   deltaCREB   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADIPOR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADIPOR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADIPOR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202909:  view genomic region     (about GC identifiers)

Start:
202,909,951 bp from pter      End:
202,927,700 bp from pter
Size:
17,750 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54 (See protein sequence)
Recommended Name: Adiponectin receptor protein 1  
Size: 375 amino acids; 42616 Da
Subunit: May form homomultimer and heteromultimers
Subcellular location: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular
organelles
Sequence caution: Sequence=AAD34040.1; Type=Frameshift; Positions=369;
Secondary accessions: B3KMB0 Q53HS7 Q53YY6 Q9Y360

Explore the universe of human proteins at neXtProt for ADIPOR1: NX_Q96A54

Explore proteomics data for ADIPOR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A54

  • ADIPOR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADIPOR1 Protein Expression
    REFSEQ proteins: NP_057083.2  
    ENSEMBL proteins: 
     ENSP00000341785   ENSP00000402178   ENSP00000392946   ENSP00000395469   ENSP00000356223  

    Human Recombinant Protein Products for ADIPOR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ADIPOR1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for ADIPOR1 
    OriGene Custom Protein Services for ADIPOR1
    GenScript Custom Purified and Recombinant Proteins Services for ADIPOR1
    Novus Biologicals ADIPOR1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADIPOR1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19233263
    GO:0016021integral to membrane NAS12802337

    ADIPOR1 for ontologies           About GeneDecksing



    ADIPOR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADIPOR1
    OriGene Custom Antibody Services for ADIPOR1
    GenScript Custom Superior Antibodies Services for ADIPOR1
    Novus Biologicals ADIPOR1 Antibodies
    Abcam antibodies for ADIPOR1
    Cloud-Clone Corp. Antibodies for ADIPOR1 
    ThermoFisher Antibody for ADIPOR1
    LSBio Antibodies in human, mouse, rat for ADIPOR1 

    Assay Products for ADIPOR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADIPOR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADIPOR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADIPOR1 
    Cloud-Clone Corp. CLIAs for ADIPOR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADIPOR: GPCR / Unclassified : Adiponectin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Adipo1 receptor 
    Adiponectin receptors

    1 InterPro protein domain:
     IPR004254 HlyIII-related

    Graphical View of Domain Structure for InterPro Entry Q96A54

    ProtoNet protein and cluster: Q96A54

    1 Blocks protein domain: IPB004254 Hly-III related proteins

    UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
    Domain: The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular
    Similarity: Belongs to the ADIPOR family


    ADIPOR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADR1_HUMAN, Q96A54
    Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes
    that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as
    fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by
    adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length
    adiponectin

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IPI19233263
    GO:0042562hormone binding IDA12802337
    GO:0042802identical protein binding IEA--
         
    ADIPOR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADIPOR1:
     Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adipor1):
     adipose tissue  behavior/neurological  cellular  growth/size  homeostasis/metabolism 
     liver/biliary system  muscle  normal 

    ADIPOR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adipor1tm1Tka for ADIPOR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADIPOR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADIPOR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADIPOR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADIPOR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADIPOR1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADIPOR1:
    hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidADIPOR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADIPOR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADIPOR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADIPOR1
    Sirion Biotech Customized adenovirus for overexpression of ADIPOR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADIPOR1 (see all 13)
    OriGene ORF clones in mouse, rat for ADIPOR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOR1 (NM_015999)
    Sino Biological Human cDNA Clone for ADIPOR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADIPOR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR1
    Sirion Biotech Customized lentivirus for stable overexpression of ADIPOR1 
                         Customized lentivirus expression plasmids for stable overexpression of ADIPOR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADIPOR1
    Search LifeMap BioReagents cell lines for ADIPOR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADIPOR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Adipocytokine signaling pathway
    Adipocytokine signaling pathway
    3AMPK signaling
    AMPK signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADIPOR1
        AMPK signaling



    2         Kegg Pathways  (Kegg details for ADIPOR1):
        Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)


    ADIPOR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADIPOR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for ADIPOR1 (Q96A541, 3 ENSP000003417854) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG11, 3, ENSP000002882664EBI-1632076,EBI-741243 I2D: score=2 STRING: ENSP00000288266
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    APPL2Q8NEU83, ENSP000002585304I2D: score=1 STRING: ENSP00000258530
    ADIPOR1Q96A541EBI-1632076,EBI-1632076
    ADIPOQENSP000003207094STRING: ENSP00000320709
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009755hormone-mediated signaling pathway IDA12802337
    GO:0019395fatty acid oxidation IDA12802337

    ADIPOR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADIPOR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADIPOR1 (ADR1)

    10/12 Novoseek inferred chemical compound relationships for ADIPOR1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 52.6 25 17426101 (2), 18294218 (2), 17878241 (2), 17285539 (2) (see all 15)
    fatty acid 50.4 9 20032495 (2), 16603155 (1), 17786081 (1), 16055297 (1) (see all 8)
    pioglitazone 43.5 6 16023994 (1), 19169664 (1)
    c-peptide 42.8 1 15331527 (1)
    lipid 33.5 7 20032495 (1), 16023994 (1), 18288417 (1), 16756736 (1) (see all 6)
    rosiglitazone 18.1 6 15991021 (4), 15824748 (1)
    p002 5.68 2 15991021 (1)
    p003 3.48 1 15105989 (1)
    cholesterol 0 1 15331527 (1)
    steroid 0 2 19453184 (1), 19671624 (1)

    Search CenterWatch for drugs/clinical trials and news about ADIPOR1 / ADR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADIPOR1 gene (2 alternative transcripts): 
    NM_001127687.1  NM_015999.4  

    Unigene Cluster for ADIPOR1:

    Adiponectin receptor 1
    Hs.713729  [show with all ESTs]
    Unigene Representative Sequence: NM_015999
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340990(uc010pqd.2 uc001gyq.4 uc001gyr.4) ENST00000495562
    ENST00000417068 ENST00000426229 ENST00000436244(uc001gys.4) ENST00000367254

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADIPOR1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADIPOR1:
    hsa-miR-323-3p hsa-miR-187* hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidADIPOR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADIPOR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADIPOR1
    Clone
    Products:
         
    OriGene clones in human, mouse for ADIPOR1 (see all 13)
    OriGene ORF clones in mouse, rat for ADIPOR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOR1 (NM_015999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADIPOR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR1
    Sirion Biotech Customized lentivirus for stable overexpression of ADIPOR1 
                         Customized lentivirus expression plasmids for stable overexpression of ADIPOR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADIPOR1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADIPOR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADIPOR1

    Additional mRNA sequence: 

    AF125179.1 AF125180.1 AF151803.1 AK001484.1 AK058114.1 AK124455.1 AK222503.1 AY424279.1 
    BC001594.2 BC010743.1 NR_046083.1 

    24 DOTS entries:

    DT.91764040  DT.100887669  DT.91764021  DT.121345272  DT.99953287  DT.100887661  DT.100676782  DT.102829862 
    DT.97766849  DT.100887665  DT.91764038  DT.92032781  DT.100887653  DT.100887654  DT.100887662  DT.100887666 
    DT.100887668  DT.121345286  DT.121345332  DT.91764014  DT.91764023  DT.95169465  DT.95169474  DT.97782992 

    24/569 AceView cDNA sequences (see all 569):

    BQ223992 BF593983 BI254173 CR626149 CR590124 AI827291 BQ932233 BM692694 
    BF082129 CR599130 CR619012 BG683091 AI955265 AA890343 BE855449 BX388776 
    BX349860 BM798762 AI916562 N45446 BM788473 AI635116 C21303 BP334655 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
    SP1:                          -     -     -     -                 -                                                           -                                 
    SP2:        -     -     -     -     -     -                       -                                                                                             
    SP3:                          -     -     -                       -                                                                                             
    SP4:                                -     -                       -                                                                                             
    SP5:                          -     -     -     -           -     -     -     -     -     -     -                             -                                 

    ExUns: 13b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ADIPOR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADIPOR1 expression in normal human tissues (normalized intensities)      ADIPOR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTGTGTC
    ADIPOR1 Expression
    About this image


    ADIPOR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             gastrocnemius muscle   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Pancreas (Endocrine System)

    See ADIPOR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADIPOR1

    SOURCE GeneReport for Unigene cluster: Hs.713729

    UniProtKB/Swiss-Prot: ADR1_HUMAN, Q96A54
    Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in
    brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon,
    thymus and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADIPOR1: 
              Insulin Resistance in human mouse rat
              Obesity in human mouse rat
              Fatty Liver in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADIPOR1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADIPOR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADIPOR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADIPOR1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adipor11 , 5 adiponectin receptor 11, 5 90.93(n)1
    96.8(a)1
      1 (58.22 cM)5
    726741  NM_028320.31  NP_082596.21 
     1344153785 
    chicken
    (Gallus gallus)
    Aves ADIPOR11 adiponectin receptor 1 80.21(n)
    91.71(a)
      421148  NM_001031027.1  NP_001026198.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADIPOR16
    --
    Uncharacterized protein
    92(a)
    76(a)
    1 ↔ 1
    possible ortholog
    GL344118.1(30058-52076)
    2(68967571-68980930)
    African clawed frog
    (Xenopus laevis)
    Amphibia adipor1-prov2 adiponectin receptor 1 78.92(n)    BC044035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.40532 Danio rerio mRNA similar to RIKEN cDNA 2810031L11 gene more 77.67(n)    BC044388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53151 CG5315 59.29(n)
    58.01(a)
      42656  NM_142804.2  NP_651061.1 
    worm
    (Caenorhabditis elegans)
    Secernentea paqr-11 Protein PAQR-1 58.73(n)
    57.14(a)
      177416  NM_068597.4  NP_500998.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IZH3(YLR023C)4 Membrane protein involved in zinc ion homeostasis, more   --   12(187129-185498) 850710  NP_013123.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HHP41 heptahelical protein 4 47.13(n)
    41.38(a)
      829922  NM_001204017.1  NP_001190946.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02329001 hypothetical protein 47.2(n)
    41.24(a)
      4332161  NM_001056006.1  NP_001049471.1 


    ENSEMBL Gene Tree for ADIPOR1 (if available)
    TreeFam Gene Tree for ADIPOR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADIPOR1 gene
    PAQR42  PAQR32  ADIPOR22  
    2 SIMAP similar genes for ADIPOR1 using alignment to 4 protein entries:     ADR1_HUMAN (see all proteins):
    ADIPOR2    PAQR3

    ADIPOR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADIPOR1
    PGOHUM00000248258


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/442 SNPs in ADIPOR1 are shown (see all 442)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861281951,2
    --202909460(+) TTACCC/TTCCCG 2 -- int10--------
    rs2003770971,2
    --202909493(+) ACCAC-/CACACGA 2 -- int10--------
    rs665136231,2
    C--202909497(+) CCACG-/ATAGGCT 2 -- int10--------
    rs773460031,2
    C--202909593(+) CTCAGA/TCTCCC 2 -- int10--------
    rs64279811,2
    C,F,A--202909603(+) CAAAGT/CGTTGG 2 -- int15Minor allele frequency- C:0.20NA 10
    rs1121576161,2
    C,F--202909619(+) CAGGCG/ATGAGC 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs783377241,2
    C,F--202909662(+) TTGAAC/TACTAC 2 -- int13Minor allele frequency- T:0.12WA NA EA 358
    rs1389704871,2
    C--202909693(+) AACAAA/GATGGT 2 -- int10--------
    rs569346001,2
    C,F--202909737(+) AATTTA/TAAAAT 2 -- int16Minor allele frequency- T:0.27WA NA CSA EA 363
    rs75395421,2
    C,F,A,H--202909974(+) CAAGTG/CTCTTC 2 -- ut31 nc-transcript-variantese313Minor allele frequency- C:0.40NS EA NA WA 660

    HapMap Linkage Disequilibrium report for ADIPOR1 (202909951 - 202927700 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ADIPOR1: --

    Human Gene Mutation Database (HGMD): ADIPOR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADIPOR1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADIPOR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607945    OMIM disorders: --

    20/44 diseases for ADIPOR1 (see all 44):    About MalaCards
    nonalcoholic steatohepatitis    insulin resistance    anorexia nervosa    fatty liver disease
    morbid obesity    gestational diabetes    gastrointestinal stromal tumor    polycystic ovary syndrome
    b-cell chronic lymphocytic leukemia    obesity    chondrosarcoma    eclampsia
    pre-eclampsia    chronic obstructive pulmonary disease    liver cirrhosis    liver disease
    essential hypertension    age related macular degeneration    peritonitis    macular degeneration

    1 disease from the University of Copenhagen DISEASES database for ADIPOR1:
    Diabetes mellitus

    ADIPOR1 for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for ADIPOR1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 74.8 19 19037660 (5), 17426101 (1), 17716299 (1), 18294218 (1) (see all 11)
    insulin resistance 74.3 33 15918014 (4), 17216283 (3), 17712104 (3), 14759511 (2) (see all 20)
    obesity 64.4 13 17607322 (3), 16756736 (2), 16493120 (1), 20357764 (1) (see all 9)
    impaired glucose tolerance 40.8 3 16724230 (1), 17391161 (1), 17878241 (1)
    diabetes gestational 37.8 2 16343040 (1), 16570162 (1)
    anorexia nervosa 30.6 1 17391161 (1)
    inflammation 16.7 1 16700915 (1)
    cardiovascular diseases 15.5 1 16756736 (1)
    breast cancer 8.87 25 17123704 (6), 18451143 (2), 19524379 (2), 18288417 (2) (see all 7)
    necrosis 8.24 5 14759511 (1), 18988888 (1), 20470261 (1), 16899222 (1) (see all 5)

    Genetic Association Database (GAD): ADIPOR1
    Human Genome Epidemiology (HuGE) Navigator: ADIPOR1 (47 documents)

    Export disorders for ADIPOR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADIPOR1 gene, integrated from 9 sources (see all 243):
    (articles sorted by number of sources associating them with ADIPOR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)1, 2, 3 Yamauchi T.... Kadowaki T. (2003)
    2. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. (PubMed id 16724230)1, 4, 9 Siitonen N....Uusitupa M. (2006)
    3. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)1, 4, 9 Stefan N....Haring H.U. (2005)
    4. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)1, 4, 9 Rasmussen-Torvik L.J....Sinaiko A.R. (2009)
    5. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. (PubMed id 17003341)1, 4, 9 Soccio T....Doria A. (2006)
    6. Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans. (PubMed id 17712104)1, 4, 9 Crimmins N.A....Martin L.J. (2007)
    7. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)1, 4, 9 Hara K....Kadowaki T. (2005)
    8. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma sat urated fatty acids to modulate insulin resistance. (PubMed id 20032495)1, 4, 9 Ferguson J.F....Roche H.M. (2010)
    9. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. (PubMed id 18827209)1, 4, 9 Kaklamani V.G....Pasche B. (2008)
    10. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)1, 4, 9 Vaxillaire M....Froguel P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51094 HGNC: 24040 AceView: ADIPOR1 Ensembl:ENSG00000159346 euGenes: HUgn51094
    ECgene: ADIPOR1 Kegg: 51094 H-InvDB: ADIPOR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADIPOR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADIPOR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADIPOR1 gene:
    Search GeneIP for patents involving ADIPOR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for ADIPOR1 (AdipoR1)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADIPOR1   OriGene RNAi products in human, mouse, rat for ADIPOR1  
     OriGene qPCR primer pairs and template standards for ADIPOR1   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for ADIPOR1   OriGene clones in human, mouse for ADIPOR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1   OriGene Purified Protein for ADIPOR1  
     OriGene ORF clones in mouse, rat for ADIPOR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADIPOR1   OriGene Custom Protein Services for ADIPOR1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADIPOR1
     QIAGEN SeqTarget long-range PCR primers for resequencing ADIPOR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADIPOR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADIPOR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADIPOR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADIPOR1
     GenScript Custom Purified and Recombinant Proteins Services for ADIPOR1 GenScript cDNA clones with any tag delivered in your preferred vector for ADIPOR1
     GenScript Custom Assay Services for ADIPOR1 GenScript Custom Superior Antibodies Services for ADIPOR1
     GenScript Custom overexpressing Cell Line Services for ADIPOR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADIPOR1 promoter
     Search Chromatin IP Primers for ADIPOR1
     RT2 qPCR Primer Assay in human, mouse, rat ADIPOR1
     GNC Network for ADIPOR1
     SABiosciences PCR Arrays including human, mouse, rat ADIPOR1
     Search Tocris compounds for ADIPOR1 (ADR1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ADIPOR1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADIPOR1 antibodies
     ADIPOR1 proteins
     Antibodies for ADIPOR1
     See all of Abcam's Antibodies, Kits and Proteins for ADIPOR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADIPOR1
     Antibodies for ADIPOR1
     ELISAs for ADIPOR1
     CLIAs for ADIPOR1
     Search LifeMap BioReagents cell lines for ADIPOR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1
     SwitchGear 3'UTR luciferase reporter plasmids for ADIPOR1
     SwitchGear Promoter luciferase reporter plasmids for ADIPOR1
     ThermoFisher Antibody for ADIPOR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOR1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADIPOR1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADIPOR1
    Customized:
     lentivirus for stable overexpression of ADIPOR1
     lentivirus expression plasmids for stable overexpression of ADIPOR1
     adenovirus for overexpression of ADIPOR1
     LSBio Antibodies in human, mouse, rat for ADIPOR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADIPOR1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4