ADIPOR1 Gene

Aliases
for ADIPOR1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M199376 GC01M200198 GC01M199641 GC01M201176 GC01M174075

Summaries
for ADIPOR1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ADIPOR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: ADIPOR1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIPOR1

ADIPOR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202909:  view genomic region     (about GC identifiers)

Proteins
for ADIPOR1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ADIPOR1: NX_Q96A54

Explore proteomics data for ADIPOR1 at MOPED

Post-translational modifications: 

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Domains /
Families
for ADIPOR1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96A54

Find genes that share domains with ADIPOR1           About GenesLikeMe

Function
for ADIPOR1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

(inferred from 4 alleles) (MGI details for Adipor1)

genOway: Develop your customized and physiologically relevant rodent model for ADIPOR1

miRNA Products:		miRTarBase miRNAs that target ADIPOR1: hsa-mir-197-3p (MIRT048047)
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ADIPOR1

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA1-10377) for ADIPOR1

Localization
for ADIPOR1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
nucleus	2
peroxisome	2
endoplasmic reticulum	1
extracellular	1
golgi apparatus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ADIPOR1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ADIPOR1 About     See pathways by source

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	SuperPath	Contained pathways About
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	Non-alcoholic fatty liver disease (NAFLD) 0.41
2	AMPK signaling	AMPK signaling
3	Adipocytokine signaling pathway	Adipocytokine signaling pathway

1 BioSystems Pathway for ADIPOR1

AMPK signaling

2 Kegg Pathways  (Kegg details for ADIPOR1)

	Adipocytokine signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for ADIPOR1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ADIPOR1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ADIPOR1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADIPOR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAGTGTGTC

About this image

Blood (Hematopoietic System)
Granulocytes Peripheral Blood
Eye (Sensory Organs)
Retina
Pancreas (Endocrine System)

Primer Products:		OriGene qPCR primer pairs and template standards for ADIPOR1 OriGene qSTAR qPCR primer pairs in human, mouse for ADIPOR1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOR1

Orthologs
for ADIPOR1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ADIPOR1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ADIPOR1 gene

PAQR4²  PAQR3²  ADIPOR2²  

2 SIMAP similar genes for ADIPOR1 using alignment to 4 protein entries:     ADR1_HUMAN (see all proteins):

ADIPOR2    PAQR3

Find genes that share paralogs with ADIPOR1           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ADIPOR1
PGOHUM00000248258

Genomic Variants
for ADIPOR1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ADIPOR1 (see all 442)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1861281951,2		--	202909460(+)	TTACCC/TTCCCG	2	--	int1		0	--	--	--	--
rs2003770971,2		--	202909493(+)	ACCAC-/CACACGA	2	--	int1		0	--	--	--	--
rs665136231,2	C	--	202909497(+)	CCACG-/ATAGGCT	2	--	int1		0	--	--	--	--
rs773460031,2	C	--	202909593(+)	CTCAGA/TCTCCC	2	--	int1		0	--	--	--	--
rs64279811,2	C,F,A	--	202909603(+)	CAAAGT/CGTTGG	2	--	int1		5		NA	10
rs1121576161,2	C,F	--	202909619(+)	CAGGCG/ATGAGC	2	--	int1		2		WA CSA	4
rs783377241,2	C,F	--	202909662(+)	TTGAAC/TACTAC	2	--	int1		3		WA NA EA	358
rs1389704871,2	C	--	202909693(+)	AACAAA/GATGGT	2	--	int1		0	--	--	--	--
rs569346001,2	C,F	--	202909737(+)	AATTTA/TAAAAT	2	--	int1		6		WA NA CSA EA	363
rs75395421,2	C,F,A,H	--	202909974(+)	CAAGTG/CTCTTC	2	--	ut31 nc-transcript-variantese3		13		NS EA NA WA	660

HapMap Linkage Disequilibrium report for ADIPOR1 (202909951 - 202927700 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ADIPOR1: --
Human Gene Mutation Database (HGMD): ADIPOR1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ADIPOR1

DNA2.0 Custom Variant and Variant Library Synthesis for ADIPOR1

Disorders / Diseases
for ADIPOR1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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3 diseases for ADIPOR1

Selected Novoseek inferred disease relationships for ADIPOR1 gene (see all 13)    About this table

Publications
for ADIPOR1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADIPOR1 gene, integrated from 10 sources (see all 251): (articles sorted by number of sources associating them with ADIPOR1)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. (PubMed id 12802337)^{1, 2, 3} Yamauchi T.... Kadowaki T. (Nature 2003)
2. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. (PubMed id 16724230)^{1, 4, 9} Siitonen N....Uusitupa M. (Diabetologia 2006)
3. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PubMed id 16205883)^{1, 4, 9} Stefan N....HAoring H.U. (Diabetologia 2005)
4. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. (PubMed id 19037660)^{1, 4, 9} Rasmussen-Torvik L.J....Sinaiko A.R. (Hum. Genet. 2009)
5. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. (PubMed id 17003341)^{1, 4, 9} Soccio T....Doria A. (Diabetes 2006)
6. Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans. (PubMed id 17712104)^{1, 4, 9} Crimmins N.A....Martin L.J. (Obesity (Silver Spring) 2007)
7. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PubMed id 15918014)^{1, 4, 9} Hara K....Kadowaki T. (Diabetologia 2005)
8. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PubMed id 20032495)^{1, 4, 9} Ferguson J.F....Roche H.M. (Am. J. Clin. Nutr. 2010)
9. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. (PubMed id 18827209)^{1, 4, 9} Kaklamani V.G....Pasche B. (JAMA 2008)
10. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PubMed id 16505255)^{1, 4, 9} Vaxillaire M....Froguel P. (Diabetes 2006)

External Searches for ADIPOR1 gene

Genome Databases showing ADIPOR1 gene

Other Databases showing ADIPOR1 gene

Specialized Databases showing ADIPOR1 gene

Products
for ADIPOR1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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