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ADIPOQ Gene

protein-coding   GIFtS: 63
GCID: GC03P186560

Adiponectin, C1Q And Collagen Domain Containing

(Previous names: adipocyte, C1Q and collagen domain containing)
(Previous symbol: ACDC)
  See ADIPOQ-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adiponectin, C1Q And Collagen Domain Containing1 2     Adiponectin Precursor1
ACDC1 2 3     Adipose Most Abundant Gene Transcript 11
APM12 3 5     ADPN2
GBP282 3 5     APM-12
Adipocyte Complement-Related 30 KDa Protein2 3     adiponectin2
Adipose Most Abundant Gene Transcript 1 Protein2 3     Adipose Specific Collagen-Like Factor2
30 KDa Adipocyte Complement-Related Protein2 3     Gelatin-Binding Protein 282
ACRP302 3     Adipocyte, C1q And Collagen Domain-Containing Protein3
ADIPQTL12 5     apM-13
Adipocyte, C1Q And Collagen Domain Containing1     Gelatin-Binding Protein3

External Ids:    HGNC: 136331   Entrez Gene: 93702   Ensembl: ENSG000001810927   OMIM: 6054415   UniProtKB: Q158483   

Export aliases for ADIPOQ gene to outside databases

Previous GC identifers: GC03P188044 GC03P183969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADIPOQ Gene:
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII
and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and
hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively
spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Apr 2010)

GeneCards Summary for ADIPOQ Gene:
ADIPOQ (adiponectin, C1Q and collagen domain containing) is a protein-coding gene. Diseases associated with ADIPOQ include adiponectin deficiency, and acdc. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is C1QTNF6.

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct
anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation
in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes
TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by
counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a
role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with
distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

Gene Wiki entry for ADIPOQ (Adiponectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADIPOQ gene promoter:
         GR   AML1a   Sp1   C/EBPalpha   PPAR-gamma1   GATA-6   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADIPOQ promoter sequence
   Search Chromatin IP Primers for ADIPOQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIPOQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

ADIPOQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOQ gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186560:  view genomic region     (about GC identifiers)

Start:
186,560,463 bp from pter      End:
186,576,252 bp from pter
Size:
15,790 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 (See protein sequence)
Recommended Name: Adiponectin precursor  
Size: 244 amino acids; 26414 Da
Subunit: Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes /
LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic
interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers
(middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex
assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to
HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q
domain (heterotrimeric complex) (By similarity)
Miscellaneous: Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and
Thr-164 show impaired secretion of adiponectin in any form
Miscellaneous: HMW-complex blood contents are higher in females than in males, are increased in males by
castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By
similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of
adiponectin glycosylation are significantly decreased as compared with healthy controls
1 PDB 3D structure from and Proteopedia for ADIPOQ:
4DOU (3D)    
Secondary accessions: Q58EX9

Explore the universe of human proteins at neXtProt for ADIPOQ: NX_Q15848

Explore proteomics data for ADIPOQ at MOPED

Post-translational modifications: 

  • Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal
    peptide in mass fingerprinting1
  • HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the
    lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the
    formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of
    adiponectin in hepatocytes (By similarity)1
  • O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to
    the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue.
    Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK
    fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the
    glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation1
  • Glycosylation2 at Thr21, Thr22, Lys65, Lys68, Lys77, Lys101

  • See ADIPOQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171271.1  NP_004788.1  

    ENSEMBL proteins: 
     ENSP00000320709   ENSP00000389814   ENSP00000405611  
    Reactome Protein details: Q15848

    ADIPOQ Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ADIPOQ Protein
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    OriGene Protein Over-expression Lysate for ADIPOQ
    OriGene MassSpec for ADIPOQ
    OriGene Custom Protein Services for ADIPOQ
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    Novus Biologicals ADIPOQ Proteins
    Novus Biologicals ADIPOQ Lysate
    Sino Biological Recombinant Protein for ADIPOQ
    Sino Biological Cell Lysate for ADIPOQ
    ProSpec Recombinant Protein for ADIPOQ
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ADIPOQ 

     
    antibodies-online proteins for ADIPOQ (135 products) 

     
    antibodies-online peptides for ADIPOQ

    ADIPOQ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADIPOQ
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    OriGene Antibodies for ADIPOQ
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    Search for Antibodies for ADIPOQ at Abcam
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    antibodies-online antibodies for ADIPOQ (382 products) 

    ADIPOQ Assay Products:

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    eBioscience ELISAs for ADIPOQ:  
                        Human Adiponectin Platinum ELISA 96 tests
    antibodies-online kits for ADIPOQ (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR028572 Adiponectin
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR008160 Collagen
     IPR001073 C1q

    Graphical View of Domain Structure for InterPro Entry Q15848

    ProtoNet protein and cluster: Q15848

    3 Blocks protein domains:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Domain: The C1q domain is commonly called the globular domain
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain


    Find genes that share domains with ADIPOQ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADIPO_HUMAN, Q15848
    Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct
    anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation
    in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes
    TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by
    counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a
    role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with
    distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS--
    GO:0005125cytokine activity NAS12611609
    GO:0005179hormone activity IDA11222466
    GO:0005515protein binding IPI12070119
    GO:0033691sialic acid binding IDA19855092
         
    Find genes that share ontologies with ADIPOQ           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Adipoq) (see all 17):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  renal/urinary system  respiratory system 

    Find genes that share phenotypes with ADIPOQ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADIPOQ: Adipoqtm1Chan Adipoqtm1Pesch Adipoqtm1Far Adipoqtm1Tka Adipoqtm1Ish

       genOway: Develop your customized and physiologically relevant rodent model for ADIPOQ

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ADIPOQ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADIPOQ (see all 16):
    hsa-miR-577 hsa-miR-548p hsa-miR-3132 hsa-miR-551b* hsa-miR-3133 hsa-miR-548aa hsa-miR-3921 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidADIPOQ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADIPOQ
    Predesigned siRNA for gene silencing in human, mouse, rat ADIPOQ

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ADIPOQ (see all 11)
    OriGene ORF clones in mouse, rat for ADIPOQ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOQ (NM_004797)
    Sino Biological Human cDNA Clone for ADIPOQ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADIPOQ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADIPOQ

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ADIPOQ 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOQ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADIPO_HUMAN, Q15848: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0005615extracellular space IDA10403784
    GO:0005783endoplasmic reticulum ISS--
    GO:0009986cell surface IDA10982546

    Find genes that share ontologies with ADIPOQ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADIPOQ About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    2L1CAM interactions
    Developmental Biology0.63
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    5IL-9 Signaling Pathways
    Adipocytokines and Insulin Signaling0.34


    Find genes that share SuperPaths with ADIPOQ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ADIPOQ
        Adipocytokines & Insulin Signaling

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ADIPOQ
        AMPK Enzyme Complex Pathway

    1 Cell Signaling Technology (CST) Pathway for ADIPOQ
        Glucose / Energy Metabolism

    3 BioSystems Pathways for ADIPOQ
        Adipogenesis
    AMPK signaling
    Type II diabetes mellitus


    1 Reactome Pathway for ADIPOQ
        Transcriptional regulation of white adipocyte differentiation


    4 Kegg Pathways  (Kegg details for ADIPOQ):
        PPAR signaling pathway
    Adipocytokine signaling pathway
    Type II diabetes mellitus
    Non-alcoholic fatty liver disease (NAFLD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOQ (see all 9): 
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Obesity in human mouse rat
              Cytokines & Chemokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADIPOQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADIPOQ (Q158483 ENSP000003207094) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH13P552903, ENSP000002686134I2D: score=1 STRING: ENSP00000268613
    ADIPOR2Q86V243, ENSP000003496164I2D: score=2 STRING: ENSP00000349616
    C1QAP027453I2D: score=1 
    CEBPBENSP000003054224STRING: ENSP00000305422
    FABP4ENSP000002561044STRING: ENSP00000256104
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001934positive regulation of protein phosphorylation IDA18431508
    GO:0006006glucose metabolic process ISS--
    GO:0006091generation of precursor metabolites and energy TAS10095105
    GO:0006635fatty acid beta-oxidation ISS--

    Find genes that share ontologies with ADIPOQ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADIPOQ (ADIPO)

    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Pharmaceutical: Adiponectin might be used in the treatment of diabetes type 2 and insulin resistance

    1 HMDB Compound for ADIPOQ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for ADIPOQ gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 86.9 1335 16580118 (9), 16236252 (6), 17418606 (6), 17706206 (6) (see all 99)
    pioglitazone 83 167 19933924 (7), 18824177 (5), 18455831 (4), 18664597 (4) (see all 75)
    cholesterol 78.8 595 19878382 (4), 16793964 (4), 16574896 (4), 18063927 (4) (see all 99)
    lipid 77.9 483 15543224 (5), 19874712 (5), 12660875 (4), 16571847 (4) (see all 99)
    rosiglitazone 77.9 127 17932317 (5), 12466369 (4), 18036314 (3), 16546473 (3) (see all 69)
    metformin 76.5 64 18192541 (3), 16839832 (3), 16624028 (3), 16118250 (2) (see all 45)
    nash 73.7 75 16231364 (5), 18923878 (4), 15718867 (4), 18311774 (3) (see all 30)
    rimonabant 71.6 41 19211723 (5), 18951999 (3), 18426513 (1), 18457636 (1) (see all 25)
    thiazolidinedione 69.1 29 19381067 (5), 18664597 (2), 19622782 (2), 16352858 (2) (see all 13)
    fatty acid 68.2 165 17173081 (5), 16936205 (4), 15637134 (3), 20237168 (3) (see all 99)



    Find genes that share compounds with ADIPOQ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADIPOQ gene (2 alternative transcripts): 
    NM_001177800.1  NM_004797.3  

    Unigene Cluster for ADIPOQ:

    Adiponectin, C1Q and collagen domain containing
    Hs.80485  [show with all ESTs]
    Unigene Representative Sequence: NM_001177800
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320741 ENST00000444204(uc010hyy.3) ENST00000412955(uc003fra.3)

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    hsa-miR-577 hsa-miR-548p hsa-miR-3132 hsa-miR-551b* hsa-miR-3133 hsa-miR-548aa hsa-miR-3921 hsa-miR-3916
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      QuantiTect SYBR Green Assays in human, mouse, rat ADIPOQ
      QuantiFast Probe-based Assays in human, mouse, rat ADIPOQ

    Additional mRNA sequence: 

    AK291525.1 AK312868.1 AL832470.1 BC054496.1 BC096308.3 BC096309.3 BC096310.3 BC096311.3 
    D45371.1 EU420013.1 NR_046662.1 

    4 DOTS entries:

    DT.95360042  DT.97786567  DT.100659899  DT.101966091 

    Selected AceView cDNA sequences (see all 45):

    CD514622 AU121917 CB266525 BQ889392 NM_004797 CB265535 CB265759 CD515608 
    BX282473 CD516758 CB999000 AX767959 H16116 BQ717765 AA321105 AL832470 
    CB270806 F16273 AU147646 BQ876848 AA339798 CD000104 CD516223 CD104471 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for ADIPOQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADIPOQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTGGGTA
    ADIPOQ Expression
    About this image


    ADIPOQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 12 entries
             Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
             Body Subcutaneous White Adipose
             White adipocyte-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
    ADIPOQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADIPOQ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80485

    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Tissue specificity: Synthesized exclusively by adipocytes and secreted into plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADIPOQ (see all 9): 
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Obesity in human mouse rat
              Cytokines & Chemokines in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADIPOQ gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adipoq1 , 5 adiponectin, C1Q and collagen domain containing1, 5 80.56(n)1
    84.65(a)1
      16 (13.96 cM)5
    114501  NM_009605.41  NP_033735.31 
     231465365 
    chicken
    (Gallus gallus)
    Aves ADIPOQ1 adiponectin, C1Q and collagen domain containing 70.11(n)
    74.18(a)
      404536  NM_206991.1  NP_996874.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADIPOQ6
    adiponectin, C1Q and collagen domain containing
    61(a)
    1 ↔ 1
    3(28732138-28745320)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adipoq1 adiponectin, C1Q and collagen domain containing 64.9(n)
    64.73(a)
      448269  NM_001005793.1  NP_001005793.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adipoqb1 adiponectin, C1Q and collagen domain containing, b 65.62(n)
    61.88(a)
      751715  NM_001045425.2  NP_001038890.1 


    ENSEMBL Gene Tree for ADIPOQ (if available)
    TreeFam Gene Tree for ADIPOQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADIPOQ gene
    C1QTNF62  C1QB2  COL10A12  C1QTNF12  C1QTNF9B2  C1QA2  C1QTNF42  COL8A22  
    C1QTNF92  C1QTNF52  COL8A12  OTOL12  C1QTNF82  C1QTNF72  C1QC2  C1QTNF22  
    16 SIMAP similar genes for ADIPOQ using alignment to 2 protein entries:     ADIPO_HUMAN (see all proteins):
    C1QTNF9    C1QTNF9B    OTOL1    C1QTNF1    C1QB    C1QC
    C1QA    C1QL1    C1QTNF2    C1QTNF5    C1QTNF7    COL10A1
    COL8A1    C1QL2    C1QTNF6    dJ151B14.4

    Find genes that share paralogs with ADIPOQ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADIPO_HUMAN, Q15848: Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the
    adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]


    Selected SNPs for ADIPOQ (see all 685)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0132744
    Adiponectin deficiency (ADPND)4--see VAR_0132742 R C mis40--------
    rs1219178151,2
    Cpathogenic1186441160(+) TATACC/TGCTCA 4 R C mis11Minor allele frequency- T:0.00EU 1279
    rs1484607601,2
    --186427532(+) ACAAAG/TTATTT 2 -- us2k10--------
    rs1853208551,2
    --186427534(+) AAATTA/TTTTAC 2 -- us2k10--------
    rs1905764381,2
    --186427588(+) TAATAA/GTTATC 2 -- us2k10--------
    rs1828191271,2
    --186427698(+) AACTTG/TGAATA 2 -- us2k10--------
    rs2667301,2
    C,F--186427781(+) aggctG/Agagcg 2 -- us2k19Minor allele frequency- A:0.12NA WA CSA 16
    rs1864160331,2
    C--186427838(+) TGATTC/GTCTTG 2 -- us2k10--------
    rs1476431711,2
    --186427848(+) GTCTCA/GGCCTC 2 -- us2k10--------
    rs1422733001,2
    --186427858(+) CCCAAA/GTAGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADIPOQ (186560463 - 186576252 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ADIPOQ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4155CNV Loss18451855
    nsv508263CNV Loss20534489
    esv34136CNV Loss18971310
    nsv246CNV Loss15895083
    nsv878071CNV Gain21882294
    dgv1541e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ADIPOQ
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADIPOQ
    DNA2.0 Custom Variant and Variant Library Synthesis for ADIPOQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605441   
    OMIM disorders: 612556  
    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
  • Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of
    plasma adiponectin. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • Selected diseases for ADIPOQ (see all 25):    
    About MalaCards
    adiponectin deficiency    acdc    chronic pulmonary heart disease    acquired generalized lipodystrophy
    hypertensive retinopathy    arteriosclerosis obliterans    arteriolosclerosis    lipoatrophic diabetes
    arteriosclerosis    idiopathic recurrent pericarditis    berardinelli-seip congenital lipodystrophy    sleep apnea
    nonalcoholic steatohepatitis    laron syndrome    glucose intolerance    carotid intimal medial thickness
    lipodystrophy    polycystic ovary syndrome    familial partial lipodystrophy    liver disease


    Find genes that share disorders with ADIPOQ           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADIPOQ gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 95.2 1379 15292306 (6), 19486470 (6), 12574192 (5), 18253163 (5) (see all 99)
    insulin sensitivity 93.9 899 16373895 (7), 19107128 (7), 19037660 (6), 15627868 (6) (see all 99)
    obesity 90.8 826 19490068 (5), 20058257 (4), 12436346 (4), 20221876 (4) (see all 99)
    cardiovascular diseases 80.5 228 18027814 (5), 17253436 (3), 16581078 (3), 19389061 (3) (see all 99)
    fatty liver 80.1 79 17022944 (3), 15793855 (2), 17006986 (2), 18376369 (2) (see all 58)
    dyslipidemia 78.6 43 17714716 (2), 16556684 (2), 19804051 (2), 15798954 (1) (see all 39)
    atherosclerosis 78.3 255 16886584 (4), 19732605 (3), 18774612 (3), 15928248 (3) (see all 99)
    niddm 78.2 110 18027814 (4), 17046560 (3), 17445536 (3), 19922965 (3) (see all 80)
    lipodystrophy 76.2 31 12713059 (4), 12574192 (2), 14738456 (2), 15651750 (2) (see all 20)
    inflammation 75.5 333 17418606 (4), 16926246 (4), 18799090 (4), 15934913 (3) (see all 99)

    Genetic Association Database (GAD): ADIPOQ
    Human Genome Epidemiology (HuGE) Navigator: ADIPOQ (268 documents)

    Export disorders for ADIPOQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADIPOQ gene, integrated from 10 sources (see all 3614):
    (articles sorted by number of sources associating them with ADIPOQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. (PubMed id 12086969)1, 2, 4 Kondo H.... Matsuzawa Y. (Diabetes 2002)
    2. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (PubMed id 11812766)1, 2, 4 Hara K.... Kadowaki T. (Diabetes 2002)
    3. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. (PubMed id 12354786)1, 2, 4 Vasseur F.... Froguel P. (Hum. Mol. Genet. 2002)
    4. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. (PubMed id 19855092)1, 2, 9 Richards A.A.... Whitehead J.P. (Mol. Endocrinol. 2010)
    5. Postprandial plasma adiponectin decreases after glucose and high fat meal and is independently associated with postprandial triacylglycerols but not with -- 11388 promoter polymorphism. (PubMed id 17663805)1, 4, 9 Rubin D....Schrezenmeir J. (Br. J. Nutr. 2008)
    6. Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study. (PubMed id 19761474)1, 4, 9 Menzaghi C....Trischitta V. (J. Intern. Med. 2010)
    7. ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity. (PubMed id 19543786)1, 4, 9 Ntalla I....Talmud P.J. (Eur J Nutr 2009)
    8. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. (PubMed id 18776141)1, 4, 9 Hivert M.F....Meigs J.B. (Diabetes 2008)
    9. Hypoadiponectinemia is associated with progression toward type 2 diabetes and genetic variation in the ADIPOQ gene promoter. (PubMed id 16801592)1, 4, 9 Schwarz P.E....Vasseur F. (Diabetes Care 2006)
    10. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. (PubMed id 12878598)1, 2, 9 Waki H.... Kadowaki T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9370 HGNC: 13633 AceView: ACDC Ensembl:ENSG00000181092 euGenes: HUgn9370
    ECgene: ADIPOQ Kegg: 9370 H-InvDB: ADIPOQ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADIPOQ Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Adiponectin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADIPOQ gene:
    Search GeneIP for patents involving ADIPOQ

    GeneCards and IP:
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