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ADIPOQ Gene

protein-coding   GIFtS: 66

GC03P188044
adiponectin, C1Q and collagen domain containing
(Previous names: adipocyte, C1Q and collagen domain containing )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACDC)
Services    

Aliases &
Descriptions
for ADIPOQ

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ACDC 2, 3
ACRP30 1, 2, 3
ADIPQTL1 2, 5
ADPN 2
APM-1 2
APM1 2, 3, 5
AdipoQ 1
GBP28 1, 2, 3, 5
adiponectin 1, 2
apM-1 3
apM1 1
Descriptions
30 kDa adipocyte complement-related protein 3
Adipocyte complement-related 30 kDa protein 3
Adipocyte, C1q and collagen domain-containing protein 3
Adipose most abundant gene transcript 1 protein 3
Gelatin-binding protein 3
adipocyte, C1Q and collagen domain containing 1, 2
adipocyte, C1Q and collagen domain-containing 2
adiponectin, C1Q and collagen domain containing 2
adipose most abundant gene transcript 1 2
gelatin-binding protein 28 2
External Ids
HGNC: 136331
Entrez Gene: 93702
UniProtKB: Q158483
Ensembl: ENSG000001810927
Search outside databases for aliases for ADIPOQ gene

Summaries
for ADIPOQ

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ADIPOQ:
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to
collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and
is involved with metabolic and hormonal processes. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity,
with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK
phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization
and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in
various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits
endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,
angiogenesis and tissue remodeling by binding and sequestering various growth factors with
distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

Gene Wiki entry for ADIPOQ (Adiponectin)

Genomic Location
for ADIPOQ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADIPOQ gene  

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

ADIPOQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P188044:     (about GC identifiers)

Start:
 188,043,157 bp from pter
End:
 188,058,946 bp from pter
Size:
 15,790 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  

Proteins
for ADIPOQ

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 (See protein sequence)
Recommended Name: Adiponectin precursor  
Size: 244 amino acids; 26414 Da
Subunit: Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular
weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains
in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can
associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger
complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionnally on
lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW
complexes bind to PDGFB, and HMW complex binds to FGF2
Subcellular location: Secreted
Miscellaneous: Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants
Cys-112 and Thr-164 show impaired secretion of adiponectin in any form
Miscellaneous: HMW-complex blood contents are higher in females than in males, are increased in
males by castration and decreased again upon subsequent testosterone treatment, which blocks
HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to
total adiponectin and the degree of adiponectin glycosylation are significantly decreased as
compared with healthy controls
Secondary accessions: Q58EX9

Post-translational modifications:

  • Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of
    the N-terminal peptide in mass fingerprinting1
  • HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and
    glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be
    critically involved in regulating the formation and/or secretion of HMW complexes and consequently
    contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity)1
  • O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally
    added hydroxyl groups1
  • Not N-glycosylated1


    • REFSEQ proteins: NP_004788.1  

    ENSEMBL proteins: 
    ENSP00000320709 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ADIPOQ (Adiponectin/Acrp30)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Adiponectin)
    Human Recombinant Proteins from Abnova (ADIPOQ)
                  OriGene Purified Recombinant Human Protein: ADIPOQ 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space IEA--
    GO:0005783 endoplasmic reticulum IEA--
    About this table

    Antibodies for ADIPOQ: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ADIPOQ
    Sigma-Aldrich Antibodies for ADIPOQ
    R&D Systems Antibodies for ADIPOQ (Adiponectin/Acrp30)
    Cell Signaling Technology (CST) Antibodies for ADIPOQ  (Adiponectin)
    Antibodies from Abcam (Adiponectin), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ADIPOQ)
    Novus Biologicals Antibodies for ADIPOQ

    Assays for ADIPOQ: 
    Invitrogen Assays for ADIPOQ
    Millipore Kits and Assays for the Analysis of ADIPOQ
    R&D Systems ELISAs for ADIPOQ (Adiponectin/Acrp30)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ADIPOQ

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR008983 Tumour_necrosis_fac-like
     IPR008160 Collagen
     IPR001073 C1q


       GeneDecks  ADIPOQ for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15848

    ProtoNet protein and cluster: Q15848

    3 Blocks protein families:
    IPB001073 Complement C1q protein
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Domain: The C1q domain is commonly called the globular domain
    Similarity: Contains 1 C1q domain
    Similarity: Contains 1 collagen-like domain

    Gene Function
    for ADIPOQ

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADIPOQ)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADIPOQ)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004797

                  Applied Biosystems Silencer® siRNAs for ADIPOQ

                  Sigma-Aldrich siRNA for ADIPOQ  
                         Sigma-Aldrich shRNA for ADIPOQ  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004797
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004797
                                     untagged cDNA clone in CMV expression vector: NM_004797 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004797

    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity,
    with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK
    phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization
    and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in
    various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits
    endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,
    angiogenesis and tissue remodeling by binding and sequestering various growth factors with
    distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

    15/18 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Adipoq) (see all 18 ):

    adipose tissuebehavior/neurologicalcellularendocrine/exocrine gland
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-prenatal/perinatal
    life span-post-weaning/agingliver/biliary systemmusclerenal/urinary systemreproductive system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125 cytokine activity NAS12611609
    GO:0005179 hormone activity IEA--
    GO:0042803 protein homodimerization activity IPI12021245
    GO:0043499 eukaryotic cell surface binding IDA10982546
    About this table

    Pathways & Interactions
    for ADIPOQ

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for ADIPOQ
     Selected targets of C/EBPbeta
     Selected targets of C/EBPalpha

       GeneDecks  ADIPOQ for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  ADIPOQ  (Your Favorite Gene powered by Ingenuity) 
     PPAR&alpha
     Type II Diabetes Mellitus Signaling

       GeneDecks  ADIPOQ for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for ADIPOQ: 
     Akt/PKB Signaling

       GeneDecks  ADIPOQ for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for ADIPOQ):
     hsa03320 PPAR signaling pathway
     hsa04920 Adipocytokine signaling pathway
     hsa04930 Type II diabetes mellitus

       GeneDecks  ADIPOQ for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ADIPOQ 


    5/94 Interacting proteins for ADIPOQ (ENSP000003207093) via UniProtKB, MINT, and/or STRING (see all 94 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADIPOR2ENSP000003496163STRING (score=.998)
    ADIPOR1ENSP000003562233STRING (score=.997)
    INSENSP000003707313STRING (score=.991)
    PPARAENSP000002627353STRING (score=.99)
    PPARGENSP000002878203STRING (score=.973)
    About this table

    5/27 Gene Ontology (GO) biological process terms (links to tree view) (see all 27 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006 glucose metabolic process IEA--
    GO:0006091 generation of precursor metabolites and energy TAS10095105
    GO:0006635 fatty acid beta-oxidation IEA--
    GO:0009749 response to glucose stimulus IEA--
    GO:0009967 positive regulation of signal transduction IEA--
    About this table

    Drugs & Compounds
    for ADIPOQ

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADIPOQ
    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Pharmaceutical: Adiponectin might be used in the treatment of diabetes type 2 and insulin
    resistance

    10/40 Novoseek chemical compound relationships for ADIPOQ gene (see all 40 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 86.21 1101 16580118 (9), 16236252 (6), 17706206 (6), 17418606 (6) (see all 99)
    cholesterol 77.30 459 16793964 (4), 16574896 (4), 18063927 (4), 12796280 (3) (see all 99)
    lipid 76.55 412 15543224 (5), 12660875 (4), 16571847 (4), 16307747 (4) (see all 99)
    rimonabant 74.04 40 19211723 (5), 18951999 (3), 18426513 (1), 18457636 (1) (see all 24)
    nash 71.76 59 16231364 (5), 18923878 (4), 15718867 (4), 18311774 (3) (see all 22)
    fatty acid 66.51 142 17173081 (5), 16936205 (4), 15637134 (3), 15380884 (3) (see all 99)
    c-peptide 64.59 52 15168020 (3), 16308131 (2), 17938644 (2), 18330696 (2) (see all 40)
    sulfonylurea 53.87 9 18514142 (2), 18455831 (1), 18507868 (1), 19279518 (1) (see all 5)
    acadesine 51.22 3 18047638 (1), 14500570 (1), 17173081 (1)
    triacylglycerol 43.36 27 18491071 (3), 19066306 (3), 16600927 (2), 17656596 (2) (see all 14)
    About this table


    Transcripts
    for ADIPOQ

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ADIPOQ)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADIPOQ)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004797

                  Sigma-Aldrich siRNA for ADIPOQ  
                         Sigma-Aldrich shRNA for ADIPOQ  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004797  

    REFSEQ mRNAs for ADIPOQ gene: 

    NM_004797.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004797  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004797
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004797
                                     untagged cDNA clone in CMV expression vector: NM_004797 

    Additional cDNA sequence: 

    AK291525.1 AK312868.1 AL832470.1 BC054496.1 BC096308.3 BC096309.3 BC096310.3 BC096311.3 
    D45371.1 EU420013.1 

    4 DOTS entries:

    DT.95360042  DT.97786567  DT.100659899  DT.101966091 

    24/45 AceView cDNA sequences (see all 45 ):

    NM_004797 CD514622 BX282473 CD515608 CB266525 CD516758 AU121917 CB265535 
    CB265759 BQ889392 BQ876848 CB270806 AA339798 BQ717765 AL832470 AX767959 
    D45371 CD104471 CD516223 CB999000 AA321105 H16116 F16273 CD244690 

    highest scoring ESTs for ADIPOQ:

    D45371 AA339798 AL599686 AL691885 AU121917 BC054496 BQ326668 BQ717765 BQ876848 CB265535 

    Unigene Cluster for ADIPOQ:

    Adiponectin, C1Q and collagen domain containing
    Hs.80485  [show with all ESTs]
    Unigene Representative Sequence: NM_004797


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     

    About this scheme

    ECgene alternative splicing isoforms for ADIPOQ

    1 Ensembl transcript including schematic representation:
    ENST00000320741  

    Expression
    for ADIPOQ

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADIPOQ expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADIPOQ

    1 / 2 / 3

    5 probe-sets matching ADIPOQ gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		40658_r_at2, 3 U95-A 1 1.00 1.00 0.98 0.57 D45371 1.00 1.00 1.00 1
    40657_r_at2, 3 U95-A 1 1.00 1.00 0.99 0.77 H15814 0.40 1.00 0.76 1

    		69842_f_at2, 3 U95-D 684 0.38 0.01 0.13 1.98 AI766478 0.20 0.04 0.14 2

    		207175_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004797 0.60 1.00 0.82 1

    		207175_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ADIPOQ for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TAGTTGGGTA

    SOURCE GeneReport for Unigene cluster: Hs.80485

    Expression variation in blood from EXPOLDB for ADIPOQ

    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Tissue specificity: Synthesized exclusively by adipocytes and secreted into plasma

    Orthologs
    for ADIPOQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ADIPOQ gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ADIPOQ1   -- adiponectin, C1Q and collagen domain containing 87.3(n)
    84.43(a)    		 403625  NM_001006644.1  NP_001006645.1 
    chimpanzee
    (Pan troglodytes)    		 ADIPOQ1   -- adiponectin, C1Q and collagen domain containing 99.59(n)
    99.18(a)    		 471032  XM_526416.2  XP_526416.2 
    cow
    (Bos taurus)    		 ADIPOQ1   -- adiponectin, C1Q and collagen domain containing 82.7(n)
    83.54(a)    		 282865  NM_174742.2  NP_777167.1 
    rat
    (Rattus norvegicus)    		 Adipoq1   -- adiponectin, C1Q and collagen domain containing 80.05(n)
    83.2(a)    		 246253  NM_144744.2  NP_653345.1 
    mouse
    (Mus musculus)    		 Adipoq1, 5 16 (16.00 cM)5
    		 adiponectin, C1Q and collagen domain containing1, 5 79.78(n)1
    83.61(a)1    		 114501  NM_009605.41  NP_033735.31 
     AF3044665  AK0031385  (see all 14)
    About this table        Species with no ortholog for ADIPOQ

    ENSEMBL Gene Tree for ADIPOQ

    Paralogs
    for ADIPOQ

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADIPOQ gene
    ENSG000002058632  C1QTNF92  

    SNPs/Variants
    for ADIPOQ

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
    Polymorphism: Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and
    define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]


    10/161 NCBI SNPs in ADIPOQ are shown (see all 161 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs20829401,2
    		A,C,F,H,O188056858(+) TAAATC/TCTGAA 1 -- ut318Minor allele frequency- T:0.20EU EA WA NA 616
    rs10635371,2
    		A,C,F,H,O188056769(+) ATGTTC/TTTCAA 1 -- ut318Minor allele frequency- N:0.01EU EA WA NA 634
    rs10635391,2
    		A,C,F,H,O188058086(+) AGAGAG/CAGTCA 1 -- ut3111Minor allele frequency- C:0.15EU EA WA NA 980
    rs2667291,2
    		C,F,H,O188042168(+) CCTGCC/GCTTCA 1 -- ng5115Minor allele frequency- G:0.25NA EA MN EU WA 1414
    --
    rs10635381,2
    		A,C,F,H188056877(+) TCTTAT/CATGTG 1 -- ut317Minor allele frequency- C:0.48EU EA WA NA 548
    --
    rs14036971,2
    		A,C,F,H188059387(-) aaacaT/Cagaac 1 -- ng314Minor allele frequency- C:0.06EU EA WA 418
    rs67739571,2
    		C,F,H188056399(+) ATCCCA/GTATCT 1 -- ut3116Minor allele frequency- G:0.48EU EA WA NA 1470
    rs64441741,2
    		C,F,H188055883(+) AGTGCT/CGAACT 1 -- ut31 ese311Minor allele frequency- C:0.06EU EA WA NA 976
    rs173005391,2
    		C,F,H188042154(+) GAACCG/AGCTCA 1 -- ng5111Minor allele frequency- A:0.02NA EU EA WA 956
    rs173667431,2
    		C,F,H188054783(+) ATGTAT/CACCGC 1 H/Y mis1 ese311Minor allele frequency- C:0.02NA EU EA WA 982
    About this table

    HapMap Linkage Disequilibrium images for ADIPOQ (up to first 250kb)

    Disorders & Mutations
    for ADIPOQ

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 605441   disorders: 612556  

    UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

  • Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND
    results in very low concentrations of plasma adiponectin
  • Genetic variations in ADIPOQ are associated with non-insulin-dependent diabetes mellitus
    (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an
    autosomal dominant mode of inheritance, onset during adulthood and insulin resistance

    • 10/96 Novoseek disease relationships for ADIPOQ gene (see all 96 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 94.91 1160 15292306 (6), 12574192 (5), 18253163 (5), 17276175 (5) (see all 99)
    insulin sensitivity 93.89 821 16373895 (7), 19107128 (7), 19037660 (6), 15627868 (6) (see all 99)
    obesity 90.20 674 12436346 (4), 18651432 (4), 15843989 (4), 17212015 (3) (see all 99)
    cardiovascular diseases 79.38 200 18027814 (5), 17253436 (3), 16581078 (3), 19389061 (3) (see all 99)
    fatty liver 77.82 55 17022944 (3), 15793855 (2), 17006986 (2), 18376369 (2) (see all 40)
    atherosclerosis 77.54 217 16886584 (4), 19238157 (3), 15928248 (3), 17276175 (3) (see all 99)
    dyslipidemia 77.31 32 17714716 (2), 16556684 (2), 15798954 (1), 16799399 (1) (see all 29)
    hyperinsulinemia 75.99 59 12611609 (2), 12660877 (2), 15862282 (1), 16718631 (1) (see all 52)
    lipodystrophy 75.68 27 12713059 (4), 12574192 (2), 14738456 (2), 17940113 (2) (see all 17)
    niddm 75.14 83 18027814 (4), 17046560 (3), 17445536 (3), 17890872 (2) (see all 61)
    About this table

    Human Gene Mutation Database: ADIPOQ
    Genetic Association Database: ADIPOQ
    Human Genome Epidemiology Navigator: ADIPOQ (157 documents)

    Medical News
    for ADIPOQ

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for ADIPOQ

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/2325 PubMed articles for ADIPOQ gene (see all 2325 ):

    Search for ADIPOQ

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADIPOQ

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9370 HGNC: 13633 AceView: ACDC Ensembl:ENSG00000181092 euGenes: HUgn9370
    ECgene: ADIPOQ H-InvDB: ADIPOQ

    Other Databases showing ADIPOQ

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ADIPOQ

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Adiponectin

    Licensable Technologies
    for ADIPOQ

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ADIPOQ

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADIPOQ:
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     Antibodies & Assays for ADIPOQ  (Adiponectin)

     Recombinant Proteins
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for ADIPOQ




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ADIPOQ

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