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Aliases for ADIPOQ Gene

Aliases for ADIPOQ Gene

  • Adiponectin, C1Q And Collagen Domain Containing 2 3 5
  • Adipose Most Abundant Gene Transcript 1 Protein 3 4
  • Adipocyte Complement-Related 30 KDa Protein 3 4
  • 30 KDa Adipocyte Complement-Related Protein 3 4
  • ACRP30 3 4
  • APM-1 3 4
  • GBP28 3 4
  • ACDC 3 4
  • APM1 3 4
  • Adipocyte, C1q And Collagen Domain-Containing Protein 4
  • Adipocyte, C1Q And Collagen Domain Containing 2
  • Adipose Most Abundant Gene Transcript 1 2
  • Adipose Specific Collagen-Like Factor 3
  • Gelatin-Binding Protein 28 3
  • Gelatin-Binding Protein 4
  • Adiponectin Precursor 2
  • Adiponectin 3
  • ADIPQTL1 3
  • ADPN 3

External Ids for ADIPOQ Gene

Previous HGNC Symbols for ADIPOQ Gene

  • ACDC

Previous GeneCards Identifiers for ADIPOQ Gene

  • GC03P188044
  • GC03P186560
  • GC03P183969

Summaries for ADIPOQ Gene

Entrez Gene Summary for ADIPOQ Gene

  • This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

GeneCards Summary for ADIPOQ Gene

ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include Adiponectin Deficiency and Fatty Liver Disease. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is C1QTNF9.

UniProtKB/Swiss-Prot for ADIPOQ Gene

  • Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Gene Wiki entry for ADIPOQ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOQ Gene

Genomics for ADIPOQ Gene

Regulatory Elements for ADIPOQ Gene

Enhancers for ADIPOQ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F186849 0.4 ENCODE 12.4 +6.9 6899 0.2 PKNOX1 CREB3L1 ARID4B SIN3A YY1 SLC30A9 ZNF143 ZNF207 KLF13 ZNF263 ADIPOQ ADIPOQ-AS1
GH03F186902 0.2 ENCODE 11.9 +60.2 60229 0.1 ELF3 ZNF792 ZNF48 SLC30A9 GATA4 NR2F6 PAF1 NFIA FOXA3 ZHX2 ADIPOQ ADIPOQ-AS1 RPS20P14 GC03M186923
GH03F186900 1.2 Ensembl 11.9 +58.6 58633 1.0 ATF1 SAP130 NFRKB ZNF175 BACH1 ZNF48 ZNF316 TRIM24 ZNF584 HOMEZ ADIPOQ ADIPOQ-AS1 RPS20P14 GC03M186923
GH03F186882 1 Ensembl ENCODE 11.8 +40.2 40166 1.6 HDAC1 PKNOX1 ATF1 NFRKB ZBTB40 THRB ZNF766 ZNF366 ELK1 GATA2 ENSG00000223401 LOC100131635 ADIPOQ NMRAL2P RPS20P14 ADIPOQ-AS1
GH03F186821 1.5 Ensembl ENCODE 11.3 -21.0 -20986 0.6 SMARCA5 CTCF ZNF654 TRIM22 REST RAD21 RFX5 SMC3 ZBTB33 SNORA63 EIF4A2 ENSG00000200418 SNORA81 MIR1248 SNORD2 ADIPOQ AHSG KNG1 ADIPOQ-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADIPOQ on UCSC Golden Path with GeneCards custom track

Genomic Location for ADIPOQ Gene

Chromosome:
3
Start:
186,842,668 bp from pter
End:
186,858,463 bp from pter
Size:
15,796 bases
Orientation:
Plus strand

Genomic View for ADIPOQ Gene

Genes around ADIPOQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIPOQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIPOQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOQ Gene

Proteins for ADIPOQ Gene

  • Protein details for ADIPOQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15848-ADIPO_HUMAN
    Recommended name:
    Adiponectin
    Protein Accession:
    Q15848
    Secondary Accessions:
    • Q58EX9

    Protein attributes for ADIPOQ Gene

    Size:
    244 amino acids
    Molecular mass:
    26414 Da
    Quaternary structure:
    • Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex) (By similarity).
    Miscellaneous:
    • HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.
    • Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.

    Three dimensional structures from OCA and Proteopedia for ADIPOQ Gene

neXtProt entry for ADIPOQ Gene

Post-translational modifications for ADIPOQ Gene

  • HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity).
  • Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
  • O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.
  • Glycosylation at Thr 21, Thr 22, Lys 65, Lys 68, Lys 77, and Lys 101
  • Modification sites at PhosphoSitePlus

Other Protein References for ADIPOQ Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Enzo Life Sciences assays for ADIPOQ

No data available for DME Specific Peptides for ADIPOQ Gene

Domains & Families for ADIPOQ Gene

Gene Families for ADIPOQ Gene

Graphical View of Domain Structure for InterPro Entry

Q15848

UniProtKB/Swiss-Prot:

ADIPO_HUMAN :
  • The C1q domain is commonly called the globular domain.
Domain:
  • The C1q domain is commonly called the globular domain.
  • Contains 1 C1q domain.
  • Contains 1 collagen-like domain.
genes like me logo Genes that share domains with ADIPOQ: view

Function for ADIPOQ Gene

Molecular function for ADIPOQ Gene

UniProtKB/Swiss-Prot Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Gene Ontology (GO) - Molecular Function for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS 12368907
GO:0005125 cytokine activity NAS 12611609
GO:0005179 hormone activity IDA 11222466
GO:0005515 protein binding IPI 12070119
GO:0033691 sialic acid binding IDA 19855092
genes like me logo Genes that share ontologies with ADIPOQ: view
genes like me logo Genes that share phenotypes with ADIPOQ: view

Animal Models for ADIPOQ Gene

MGI Knock Outs for ADIPOQ:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADIPOQ

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADIPOQ Gene

Localization for ADIPOQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOQ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOQ Gene COMPARTMENTS Subcellular localization image for ADIPOQ gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytosol 3
mitochondrion 2
nucleus 2
peroxisome 2
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IDA 10403784
GO:0005783 endoplasmic reticulum ISS --
GO:0009986 cell surface IDA 10982546
genes like me logo Genes that share ontologies with ADIPOQ: view

Pathways & Interactions for ADIPOQ Gene

genes like me logo Genes that share pathways with ADIPOQ: view

SIGNOR curated interactions for ADIPOQ Gene

Activates:

Gene Ontology (GO) - Biological Process for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 18431508
GO:0006006 glucose metabolic process ISS 12368907
GO:0006091 generation of precursor metabolites and energy TAS 10095105
GO:0006635 fatty acid beta-oxidation ISS 12368907
genes like me logo Genes that share ontologies with ADIPOQ: view

Drugs & Compounds for ADIPOQ Gene

(96) Drugs for ADIPOQ Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pioglitazone Approved, Investigational Pharma Full agonist, Agonist 435
cyclic amp Experimental Pharma 0

(45) Additional Compounds for ADIPOQ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADIPOQ: view

Transcripts for ADIPOQ Gene

mRNA/cDNA for ADIPOQ Gene

Unigene Clusters for ADIPOQ Gene

Adiponectin, C1Q and collagen domain containing:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ADIPOQ Gene

GeneLoc Exon Structure for
ADIPOQ
ECgene alternative splicing isoforms for
ADIPOQ

Expression for ADIPOQ Gene

mRNA expression in normal human tissues for ADIPOQ Gene

mRNA differential expression in normal tissues according to GTEx for ADIPOQ Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x19.9), Adipose - Subcutaneous (x18.8), and Breast - Mammary Tissue (x8.2).

Protein differential expression in normal tissues from HIPED for ADIPOQ Gene

This gene is overexpressed in Uterus (14.6), Synovial fluid (11.7), Serum (7.3), Nasopharynx (6.7), and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADIPOQ Gene



Protein tissue co-expression partners for ADIPOQ Gene

NURSA nuclear receptor signaling pathways regulating expression of ADIPOQ Gene:

ADIPOQ

SOURCE GeneReport for Unigene cluster for ADIPOQ Gene:

Hs.80485

mRNA Expression by UniProt/SwissProt for ADIPOQ Gene:

Q15848-ADIPO_HUMAN
Tissue specificity: Synthesized exclusively by adipocytes and secreted into plasma.
genes like me logo Genes that share expression patterns with ADIPOQ: view

Primer Products

Orthologs for ADIPOQ Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADIPOQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOQ 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ADIPOQ 34
  • 87.3 (n)
APM1 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADIPOQ 34 35
  • 87.17 (n)
rat
(Rattus norvegicus)
Mammalia Adipoq 34
  • 81.1 (n)
mouse
(Mus musculus)
Mammalia Adipoq 34 16 35
  • 80.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOQ 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIPOQ 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADIPOQ 34 35
  • 70.11 (n)
lizard
(Anolis carolinensis)
Reptilia ADIPOQ 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adipoq 34
  • 64.9 (n)
zebrafish
(Danio rerio)
Actinopterygii adipoqb 34 35
  • 65.62 (n)
adipoqa 35
  • 34 (a)
OneToMany
Species where no ortholog for ADIPOQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADIPOQ Gene

ENSEMBL:
Gene Tree for ADIPOQ (if available)
TreeFam:
Gene Tree for ADIPOQ (if available)

Paralogs for ADIPOQ Gene

(16) SIMAP similar genes for ADIPOQ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADIPOQ: view

Variants for ADIPOQ Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOQ Gene

ADIPO_HUMAN-Q15848
Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556].

Sequence variations from dbSNP and Humsavar for ADIPOQ Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121917815 Adiponectin deficiency (ADPND) [MIM:612556], Pathogenic 186,854,303(+) TATAC(C/T)GCTCA nc-transcript-variant, reference, missense
rs876661321 other 186,841,714(+) GCCAA(G/T)AAAGT upstream-variant-2KB
rs1063537 -- 186,856,286(+) ATGTT(C/T)TTCAA upstream-variant-2KB, utr-variant-3-prime
rs1063538 -- 186,856,394(+) TCTTA(C/T)ATGTG upstream-variant-2KB, utr-variant-3-prime
rs1063539 -- 186,857,603(+) AGAGA(C/G)AGTCA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADIPOQ Gene

Variant ID Type Subtype PubMed ID
esv2759206 CNV loss 17122850
esv34136 CNV loss 18971310
esv3598999 CNV gain 21293372
esv3893839 CNV gain 25118596
nsv1001111 CNV gain 25217958
nsv1010626 CNV loss 25217958
nsv1012615 CNV gain 25217958
nsv246 CNV deletion 15895083
nsv4155 CNV deletion 18451855
nsv508263 CNV deletion 20534489

Variation tolerance for ADIPOQ Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIPOQ Gene

Human Gene Mutation Database (HGMD)
ADIPOQ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIPOQ

Disorders for ADIPOQ Gene

MalaCards: The human disease database

(52) MalaCards diseases for ADIPOQ Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adiponectin deficiency
  • adpnd
fatty liver disease
  • alcoholic fatty liver
glucose intolerance
  • fatty stool
acdc
  • calcification of joints and arteries
acquired generalized lipodystrophy
  • acquired lipoatrophic diabetes
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADIPO_HUMAN
  • Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin. {ECO:0000269 PubMed:10918532}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ADIPOQ

Genetic Association Database (GAD)
ADIPOQ
Human Genome Epidemiology (HuGE) Navigator
ADIPOQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIPOQ
genes like me logo Genes that share disorders with ADIPOQ: view

No data available for Genatlas for ADIPOQ Gene

Publications for ADIPOQ Gene

  1. Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study. (PMID: 19761474) Menzaghi C. … Trischitta V. (J. Intern. Med. 2010) 3 22 46 64
  2. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. (PMID: 19855092) Richards A.A. … Whitehead J.P. (Mol. Endocrinol. 2010) 3 4 22 64
  3. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (PMID: 20032495) Ferguson J.F. … Roche H.M. (Am. J. Clin. Nutr. 2010) 3 22 46 64
  4. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PMID: 19267370) Wang M.H. … Platz E.A. (Prostate 2009) 3 22 46 64
  5. ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity. (PMID: 19543786) Ntalla I. … Talmud P.J. (Eur J Nutr 2009) 3 22 46 64

Products for ADIPOQ Gene

Sources for ADIPOQ Gene

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