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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADIPOQ Gene

protein-coding GIFtS: 65
GCID: GC03P186560

adiponectin, C1Q and collagen domain containing

(Previous names: adipocyte, C1Q and collagen domain containing )
(Previous symbol: ACDC)

Explore 190 diseases affiliated with
ADIPOQ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adiponectin, C1Q And Collagen Domain Containing¹ ²		AdipoQ¹
GBP28¹ ² ³ ⁵		Adipocyte, C1Q And Collagen Domain Containing¹
ACDC¹ ² ³		ApM1¹
ACRP30¹ ² ³		ADPN²
APM1² ³ ⁵		APM-1²
Adiponectin¹		Adipose Specific Collagen-Like Factor²
Adipocyte Complement-Related 30 KDa Protein² ³		Gelatin-Binding Protein 28²
Adipose Most Abundant Gene Transcript 1 Protein² ³		Adipocyte, C1q And Collagen Domain-Containing Protein³
30 KDa Adipocyte Complement-Related Protein² ³		ApM-1¹
ADIPQTL1² ⁵		Gelatin-Binding Protein³

External Ids:	HGNC: 13633¹	Entrez Gene: 9370²	Ensembl: ENSG00000181092⁷	OMIM: 605441⁵	UniProtKB: Q15848³

Export aliases for ADIPOQ gene to outside databases

Previous GC identifers: GC03P188044 GC03P183969

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADIPOQ:

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and

complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal

processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants,

encoding the same protein, have been identified. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct

anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in

the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by

negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its

effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,

angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding

affinities, depending on the type of complex, LMW, MMW or HMW

Gene Wiki entry for ADIPOQ (Adiponectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADIPOQ gene promoter:
GR AML1a Sp1 C/EBPalpha PPAR-gamma1 GATA-6 GR-alpha PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADIPOQ promoter sequence

Search SABiosciences Chromatin IP Primers for ADIPOQ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADIPOQ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27

ADIPOQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIPOQ gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P186560: view genomic region (about GC identifiers)

Start:	186,560,463 bp from pter	End:	186,576,252 bp from pter
Size:	15,790 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 (See protein sequence)

Recommended Name: Adiponectin precursor

Size: 244 amino acids; 26414 Da

Subunit: Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW)

are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic

interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle

molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may

rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW

complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric

complex) (By similarity)

Subcellular location: Secreted

Miscellaneous: Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164

show impaired secretion of adiponectin in any form

Miscellaneous: HMW-complex blood contents are higher in females than in males, are increased in males by castration and

decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2

diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are

significantly decreased as compared with healthy controls

1 PDB 3D structure from and Proteopedia for ADIPOQ:

4DOU (3D)

Secondary accessions: Q58EX9

Explore the universe of human proteins at neXtProt for ADIPOQ: NX_Q15848

Post-translational modifications:

Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal

peptide in mass fingerprinting¹

HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine

residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation

and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in

hepatocytes (By similarity)¹

O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the

oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22

appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts.

Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated

hydroxylysines. Desialylated forms are rapidly cleared from the circulation¹

View neXtProt modification sites for NX_Q15848

ADIPOQ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171271.1 NP_004788.1

ENSEMBL proteins:

ENSP00000320709 ENSP00000389814 ENSP00000405611

Reactome Protein details: Q15848
Human Recombinant Protein Products:

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	Novus Biologicals ADIPOQ Proteins Novus Biologicals ADIPOQ Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ADIPOQ
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IDA	10403784
GO:0005783	endoplasmic reticulum	ISS	--

ADIPOQ for ontologies About GeneDecksing

ADIPOQ Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ADIPOQ
	R&D Systems Antibodies for ADIPOQ (Adiponectin/Acrp30)
	Cell Signaling Technology (CST) Antibodies for ADIPOQ (adiponectin)
	OriGene Antibodies (see all 7): ADIPOQ OriGene Custom Antibody Services for ADIPOQ
	GenScript Custom Superior Antibodies Services for ADIPOQ
	Novus Biologicals ADIPOQ Antibodies
	Abcam antibodies for ADIPOQ
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ADIPOQ

Assay Products for ADIPOQ:

	EMD Millipore Kits and Assays for the Analysis of ADIPOQ
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for ADIPOQ (Adiponectin/Acrp30) (see all)
	GenScript Custom Assay Services for ADIPOQ
	Enzo Life Sciences assays for ADIPOQ
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADIPOQ for domains About GeneDecksing

3 InterPro domains/families:

IPR008983 Tumour_necrosis_fac-like_dom

IPR008160 Collagen

IPR001073 C1q

Graphical View of Domain Structure for InterPro Entry Q15848

ProtoNet protein and cluster: Q15848

3 Blocks protein families:

IPB001073 Complement C1q protein

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Domain: The C1q domain is commonly called the globular domain

Similarity: Contains 1 C1q domain

Similarity: Contains 1 collagen-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct

anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in

the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by

negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its

effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,

angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding

affinities, depending on the type of complex, LMW, MMW or HMW

miRNA Products:		OriGene 3'-UTR Clone: ADIPOQ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADIPOQ
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ADIPOQ (see all 16):
		hsa-miR-577 hsa-miR-548p hsa-miR-3132 hsa-miR-551b* hsa-miR-3133 hsa-miR-548aa hsa-miR-3921 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: ADIPOQ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADIPOQ (see all 7) OriGene shRNA RFP: ADIPOQ OriGene siRNA: ADIPOQ
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for ADIPOQ

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		GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOQ (NM_004797)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADIPOQ
		Search LifeMap BioReagents cell lines for ADIPOQ

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIPOQ

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	ISS	12368907
GO:0005125	cytokine activity	NAS	12611609
GO:0005179	hormone activity	IDA	11222466
GO:0005515	protein binding	IPI	12070119
GO:0033691	sialic acid binding	IDA	19855092

ADIPOQ for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ADIPOQ: Adipoq^tm1Chan Adipoq^tm1Ish Adipoq^tm1Far Adipoq^tm1Pesch Adipoq^tm1Tka
     15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Adipoq) (see all 16):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	renal/urinary system	respiratory system

ADIPOQ for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Type II diabetes mellitus

Type II diabetes mellitus

1.00

Type II diabetes mellitus

0.35

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ADIPOQ

	Selected targets of C/EBPbeta
	Selected targets of C/EBPalpha

1 R&D Systems Pathway for ADIPOQ

Adipocytokines & Insulin Signaling

1 Cell Signaling Technology (CST) Pathway for ADIPOQ

Glucose / Energy Metabolism

3 BioSystems Pathways for ADIPOQ

	AMPK signaling
	Adipogenesis
	Type II diabetes mellitus

3 Reactome Pathways for ADIPOQ

	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation
	Expression of Adiponectin

3 Kegg Pathways (Kegg details for ADIPOQ):

	PPAR signaling pathway
	Adipocytokine signaling pathway
	Type II diabetes mellitus

ADIPOQ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADIPOQ

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for ADIPOQ (Q15848³ ENSP00000320709⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDH13	P55290³, ENSP00000268613⁴	I2D: score=1 STRING: ENSP00000268613
ADIPOR2	Q86V24³, ENSP00000349616⁴	I2D: score=2 STRING: ENSP00000349616
C1QA	P02745³	I2D: score=1
CEBPB	ENSP00000305422⁴	STRING: ENSP00000305422
FABP4	ENSP00000256104⁴	STRING: ENSP00000256104

About this table

Gene Ontology (GO): 5/76 biological process terms (GO ID links to tree view) (see all 76): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001934	positive regulation of protein phosphorylation	IDA	18431508
GO:0006006	glucose metabolic process	ISS	12368907
GO:0006091	generation of precursor metabolites and energy	TAS	10095105
GO:0006635	fatty acid beta-oxidation	ISS	12368907

ADIPOQ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADIPOQ for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADIPOQ
UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Pharmaceutical: Adiponectin might be used in the treatment of diabetes type 2 and insulin resistance

1 HMDB Compound for ADIPOQ About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/140 Novoseek chemical compound relationships for ADIPOQ gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	86.9	1335	16580118 (9), 16236252 (6), 17418606 (6), 17706206 (6) (see all 99)
pioglitazone	83	167	19933924 (7), 18824177 (5), 18455831 (4), 18664597 (4) (see all 75)
cholesterol	78.8	595	19878382 (4), 16793964 (4), 16574896 (4), 18063927 (4) (see all 99)
lipid	77.9	483	15543224 (5), 19874712 (5), 12660875 (4), 16571847 (4) (see all 99)
rosiglitazone	77.9	127	17932317 (5), 12466369 (4), 18036314 (3), 16546473 (3) (see all 69)
metformin	76.5	64	18192541 (3), 16839832 (3), 16624028 (3), 16118250 (2) (see all 45)
nash	73.7	75	16231364 (5), 18923878 (4), 15718867 (4), 18311774 (3) (see all 30)
rimonabant	71.6	41	19211723 (5), 18951999 (3), 18426513 (1), 18457636 (1) (see all 25)
thiazolidinedione	69.1	29	19381067 (5), 18664597 (2), 19622782 (2), 16352858 (2) (see all 13)
fatty acid	68.2	165	17173081 (5), 16936205 (4), 15637134 (3), 20237168 (3) (see all 99)

Search CenterWatch for drugs/clinical trials and news about ADIPOQ / ADIPO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADIPOQ gene (2 alternative transcripts):

NM_001177800.1 NM_004797.3

Unigene Cluster for ADIPOQ:

Adiponectin, C1Q and collagen domain containing

Hs.80485 [show with all ESTs]

Unigene Representative Sequence: NM_001177800

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000320741 ENST00000444204(uc010hyy.3) ENST00000412955(uc003fra.3)

miRNA Products:		OriGene 3'-UTR Clone: ADIPOQ Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADIPOQ
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ADIPOQ (see all 16):
		hsa-miR-577 hsa-miR-548p hsa-miR-3132 hsa-miR-551b* hsa-miR-3133 hsa-miR-548aa hsa-miR-3921 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: ADIPOQ 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADIPOQ (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADIPOQ (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADIPOQ (NM_004797)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADIPOQ
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADIPOQ

Additional cDNA sequence:

AK291525.1 AK312868.1 AL832470.1 BC054496.1 BC096308.3 BC096309.3 BC096310.3 BC096311.3

D45371.1 EU420013.1 NR_046662.1

4 DOTS entries:

DT.95360042 DT.97786567 DT.100659899 DT.101966091

24/45 AceView cDNA sequences (see all 45):

NM_004797 BX282473 BQ889392 CB266525 CD516758 CB265759 CD514622 CD515608

CB265535 AU121917 F16273 AA321105 H16116 AX767959 CD104471 CD516223

CD000104 BQ876848 CB270806 AU147646 D45371 BQ717765 CD244690 CB999000

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b
SP1:
SP2:					-

ECgene alternative splicing isoforms for ADIPOQ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADIPOQ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTGGGTA

About this image

ADIPOQ expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Adipocytes

Selective marker (cell-identifying gene)

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Visceral White Adipose

Visceral White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

Brown adipocyte-like cells (Differentiation of ...)

Adipose

Brown adipocyte-like cells (Directed differentia...)

Adipose

Immature adipocyte-like cells (Differentiation of ...)

Adipose

See ADIPOQ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADIPOQ

SOURCE GeneReport for Unigene cluster: Hs.80485

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Tissue specificity: Synthesized exclusively by adipocytes and secreted into plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including ADIPOQ (see all 9):

Terminal Differentiation Markers in human mouse rat

Insulin Resistance in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Obesity in human mouse rat

Cytokines & Chemokines in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADIPOQ gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADIPOQ¹	adiponectin, C1Q and collagen domain containing	68.25(n) 71(a)		404536 NM_206991.1 NP_996874.1
lizard (Anolis carolinensis)	Reptilia	ADIPOQ⁶	--	62(a)	1 ↔ 1	3(28735806-28744507)
zebrafish (Danio rerio)	Actinopterygii	adipoqb¹	adiponectin, C1Q and collagen domain containing, b	65.62(n) 61.88(a)		751715 NM_001045425.1 NP_001038890.1

ENSEMBL Gene Tree for ADIPOQ (if available)
TreeFam Gene Tree for ADIPOQ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADIPOQ gene

C1QL3² COL8A2² C1QL2² C1QTNF9² C1QTNF5² OTOL1² C1QB² COL10A1²

C1QTNF3² C1QTNF9B² C1QA² COL8A1² C1QL1² C1QTNF7² C1QTNF2² C1QC²

C1QL4²

18 SIMAP similar genes for ADIPOQ using alignment to 2 protein entries: ADIPO_HUMAN (see all proteins):

C1QTNF9 C1QTNF9B OTOL1 C1QTNF1 C1QB C1QC

C1QA C1QL1 C1QTNF2 C1QTNF5 C1QTNF7 COL10A1

COL8A1 C1QL2 C1QTNF6 dJ151B14.4 C1QL4 C1QTNF3

ADIPOQ for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Polymorphism: Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the

adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917815^1,2	C	pathogenic	186572092(+)	`TATACC/TGCTCA`	5	R C	nc-transcript-variantmis¹		1		EU	1279
rs148460760^1,2		--	186558463(+)	`ACAAAG/TTATTT`	2	--	us2k¹		0	--	--	--	--
rs185320855^1,2		--	186558465(+)	`AAATTA/TTTTAC`	2	--	us2k¹		0	--	--	--	--
rs190576438^1,2		--	186558519(+)	`TAATAA/GTTATC`	2	--	us2k¹		0	--	--	--	--
rs182819127^1,2		--	186558629(+)	`AACTTG/TGAATA`	2	--	us2k¹		0	--	--	--	--
rs148339840^1,2	C	--	186558664(+)	`TTTTT-/TGAGAC`	2	--	us2k¹		0	--	--	--	--
rs266730^1,2	C,F,	--	186558711(+)	`AGGCTG/AGAGCG`	2	--	us2k¹		9		NA WA CSA	16
rs186416033^1,2		--	186558768(+)	`TGATTC/GTCTTG`	2	--	us2k¹		0	--	--	--	--
rs147643171^1,2		--	186558778(+)	`GTCTCA/GGCCTC`	2	--	us2k¹		0	--	--	--	--
rs142273300^1,2		--	186558788(+)	`CCCAAA/GTAGCT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADIPOQ (186560463 - 186576252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ADIPOQ
4 CNVs: 36116 47856 3467 0564
Human Gene Mutation Database (HGMD): ADIPOQ

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADIPOQ for disorders           About GeneDecksing

OMIM gene information: 605441
OMIM disorders: 612556
UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848

Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND results in very low

concentrations of plasma adiponectin

Genetic variations in ADIPOQ are associated with non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853];

also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset

during adulthood and insulin resistance

20/190 diseases for ADIPOQ (see all 190): About MalaCards

adiponectin deficiency acdc carotid intimal medial thickness 21-hydroxylase deficiency

prader-willi syndrome acanthosis nigricans pre-eclampsia growth hormone deficiency

severe pre-eclampsia retinol binding protein arteriosclerosis obliterans glucose intolerance

lipodystrophy familial partial lipodystrophy myotonic dystrophy type 1 arterial occlusive disease

peripheral arterial occlusive disease sleep apnea metabolic syndrome x polycystic ovary syndrome

10/97 Novoseek disease relationships for ADIPOQ gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	95.2	1379	15292306 (6), 19486470 (6), 12574192 (5), 18253163 (5) (see all 99)
insulin sensitivity	93.9	899	16373895 (7), 19107128 (7), 19037660 (6), 15627868 (6) (see all 99)
obesity	90.8	826	19490068 (5), 20058257 (4), 12436346 (4), 20221876 (4) (see all 99)
cardiovascular diseases	80.5	228	18027814 (5), 17253436 (3), 16581078 (3), 19389061 (3) (see all 99)
fatty liver	80.1	79	17022944 (3), 15793855 (2), 17006986 (2), 18376369 (2) (see all 58)
dyslipidemia	78.6	43	17714716 (2), 16556684 (2), 19804051 (2), 15798954 (1) (see all 39)
atherosclerosis	78.3	255	16886584 (4), 19732605 (3), 18774612 (3), 15928248 (3) (see all 99)
niddm	78.2	110	18027814 (4), 17046560 (3), 17445536 (3), 19922965 (3) (see all 80)
lipodystrophy	76.2	31	12713059 (4), 12574192 (2), 14738456 (2), 15651750 (2) (see all 20)
inflammation	75.5	333	17418606 (4), 16926246 (4), 18799090 (4), 15934913 (3) (see all 99)

Genetic Association Database (GAD): ADIPOQ
Human Genome Epidemiology (HuGE) Navigator: ADIPOQ (268 documents)

Export disorders for ADIPOQ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADIPOQ gene, integrated from 9 sources (see all 3454):
(articles sorted by number of sources associating them with ADIPOQ)

Utopia: connect your pdf to the dynamic
world of online information

Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. (PubMed id 12086969)^{1, 2, 4} Kondo H....Matsuzawa Y. (2002)
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (PubMed id 11812766)^{1, 2, 4} Hara K.... Kadowaki T. (2002)
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. (PubMed id 12354786)^{1, 2, 4} Vasseur F.... Froguel P. (2002)
Sialic acid modification of adiponectin is not requir ed for multimerization or secretion but determines half-life in circulation. (PubMed id 19855092)^{1, 2, 9} Richards A.A....Whitehead J.P. (2010)
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. (PubMed id 12878598)^{1, 2, 9} Waki H.... Kadowaki T. (2003)
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (PubMed id 10982546)^{1, 2, 9} Ouchi N.... Matsuzawa Y. (2000)
Effect of adiponectin gene polymorphisms on circulating adiponectin and insulin resistance indexes in women with polycystic ovary syndrome. (PubMed id 15590747)^{1, 4, 9} Xita N....Tsatsoulis A. (2005)
Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. (PubMed id 15047634)^{1, 4, 9} Fumeron F....Marre M. (2004)
The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. (PubMed id 16324920)^{1, 4, 9} Jang Y....Ordovas J.M. (2006)
Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. (PubMed id 16254197)^{1, 4, 9} Gonzalez-Sanchez J.L....Serrano-Rios M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9370	HGNC: 13633	AceView: ACDC	Ensembl:ENSG00000181092	euGenes: HUgn9370
ECgene: ADIPOQ	Kegg: 9370	H-InvDB: ADIPOQ

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADIPOQ	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Adiponectin

Intellectual Property for ADIPOQ gene
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Patent Information for ADIPOQ gene:
Search GeneIP for patents involving ADIPOQ

GeneCards and IP:
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ADIPOQ Gene

adiponectin, C1Q and collagen domain containing

Aliases
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ADIPOQ (Gene Symbol)
Adiponectin, C1Q And Collagen Domain Containing
GBP28
ACDC
ACRP30
APM1
Adiponectin
Adipocyte Complement-Related 30 KDa Protein
Adipose Most Abundant Gene Transcript 1 Protein
30 KDa Adipocyte Complement-Related Protein
ADIPQTL1
AdipoQ
Adipocyte, C1Q And Collagen Domain Containing
ApM1
ADPN
APM-1
Adipose Specific Collagen-Like Factor
Gelatin-Binding Protein 28
Adipocyte, C1q And Collagen Domain-Containing Protein
ApM-1
Gelatin-Binding Protein

Fatty Liver
Microalbuminuria
Hyperinsulinemia
Prematurity
essential hypertension
Endometriosis
Obesity Morbid
Hyperlipidemia
Glucose Intolerance
insulin sensitivity
Atherosclerosis
Liver diseases
Prediabetic State
Hypercholesterolemia
Asthma
Coronary Stenosis
Coronary Atherosclerosis
Hyperlipidemia Familial Combined
Dyslipidemia
RENAL DISEASE
Malnutrition
Inflammation
Diabetic Nephropathies
Proteinuria
Hyperglycemia
Hepatitis B
Hypertrophy
LIVER DAMAGE
Rheumatoid Arthritis
Tumors
Cardiovascular Diseases
metabolic disorder
Necrosis
Liver Cirrhosis
Carotid Atherosclerosis
Preeclampsia
Coronary Heart Disease
Hyperandrogenism
Cushing Syndrome
Chronic Disease
major depression
Gastric Cancer
Cirrhosis
insulin tolerance
Leukemia Lymphocytic Chronic
Anorexia Nervosa
Hyperplasia
Liver Fibrosis
atherosclerotic plaque
Sleep Apnea Obstructive
PARTIAL LIPODYSTROPHY
Diabetes Gestational
Acromegaly
Diabetes Mellitus
abnormal secretion
Fatty Liver Alcoholic
Endocrine Effects
Arteriosclerosis
Intrauterine Growth Retardation
Metabolic Syndrome X
Acanthosis Nigricans
HEART FAILURE
Uremia
Myocardial Infarction
Albuminuria
INSULIN LIPODYSTROPHY
Coronary Artery Disease
Heart Diseases
Insulin Resistance
growth hormone deficiency
impaired glucose tolerance
Liver Diseases Alcoholic
Liver Dysfunction
Hypertriglyceridemia
Lipodystrophy
OBESITY
Polycystic Ovary Syndrome
Hepatitis C Chronic
Apnea Sleep
ventricular hypertrophy
fluid retention
Vascular Diseases
DYSFUNCTION THYROID
LIPODYSTROPHY, CONGENITAL GENERALIZED
chronic liver disease
Arteriosclerosis Obliterans
Syndrome X
NIDDM
reactive hyperemia
Prader-Willi Syndrome
Acquired generalized lipodystrophy
Endometrial Cancer
Pregnancy Complications
Psychotic
Renal Failure Chronic
Hypogonadism
Arthritis

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ADIPOQ Gene

adiponectin, C1Q and collagen domain containing

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