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Aliases & Descriptions for ADIPOQ
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ACDC 2 , 3 ACRP30 1 , 2 , 3 ADIPQTL1 2 , 5 ADPN 2 APM-1 2 APM1 2 , 3 , 5 AdipoQ 1 GBP28 1 , 2 , 3 , 5 adiponectin 1 , 2 apM-1 3 apM1 1
Descriptions 30 kDa adipocyte complement-related protein 3 Adipocyte complement-related 30 kDa protein 3 Adipocyte, C1q and collagen domain-containing protein 3 Adipose most abundant gene transcript 1 protein 3 Gelatin-binding protein 3 adipocyte, C1Q and collagen domain containing 1 , 2 adipocyte, C1Q and collagen domain-containing 2 adiponectin, C1Q and collagen domain containing 2 adipose most abundant gene transcript 1 2 gelatin-binding protein 28 2
Search outside databases for aliases for ADIPOQ gene
Summaries for ADIPOQ (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ADIPOQ : This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity tocollagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma andis involved with metabolic and hormonal processes. [provided by RefSeq] UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Function : Important adipokine involved in the control of fat metabolism and insulin sensitivity,with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPKphosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilizationand fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression invarious tissues such as liver and macrophages, and also by counteracting its effects. Inhibitsendothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,angiogenesis and tissue remodeling by binding and sequestering various growth factors withdistinct binding affinities, depending on the type of complex, LMW, MMW or HMW
Gene Wiki entry for ADIPOQ (Adiponectin)
Genomic Location for ADIPOQ
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ADIPOQ gene Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27 ADIPOQ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P188044:
(about GC identifiers )
Start:
188,043,157 bp from pter
End:
188,058,946 bp from pter
Size:
15,790 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_005612.15 Proteins for ADIPOQ
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 (See
protein sequence )Recommended Name: Adiponectin precursor Size : 244 amino acids; 26414 Da
Subunit : Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecularweight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domainsin a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers canassociate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and largercomplexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionnally onlysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMWcomplexes bind to PDGFB, and HMW complex binds to FGF2
Subcellular location : Secreted
Miscellaneous : Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variantsCys-112 and Thr-164 show impaired secretion of adiponectin in any form
Miscellaneous : HMW-complex blood contents are higher in females than in males, are increased inmales by castration and decreased again upon subsequent testosterone treatment, which blocksHMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW tototal adiponectin and the degree of adiponectin glycosylation are significantly decreased ascompared with healthy controls
Secondary accessions : Q58EX9
Post-translational modifications:
Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation ofthe N-terminal peptide in mass fingerprinting1
HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation andglycosylation of the lysine residues within the collagene-like domain of adiponectin seem to becritically involved in regulating the formation and/or secretion of HMW complexes and consequentlycontribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity)1
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationallyadded hydroxyl groups1
Not N-glycosylated1
REFSEQ proteins: NP_004788.1 ENSEMBL proteins: ENSP00000320709 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: ADIPOQ 3 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0005615 extracellular space
IEA -- GO:0005783 endoplasmic reticulum
IEA --
About this table Antibodies for ADIPOQ: Assays for ADIPOQ:
Protein
Domains/ Families for ADIPOQ(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15848 ProtoNet protein and cluster: Q15848
3 Blocks protein families : IPB001073 Complement C1q protein IPB008160 Collagen triple helix repeat IPB008161 Collagen helix repeat UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Domain : The C1q domain is commonly called the globular domainSimilarity : Contains 1 C1q domainSimilarity : Contains 1 collagen-like domain
Gene Function for ADIPOQ
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004797 Applied Biosystems Silencer ® siRNAs for ADIPOQ Sigma-Aldrich siRNA for ADIPOQ Sigma-Aldrich shRNA for ADIPOQ Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004797                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004797                                  untagged cDNA clone in CMV expression vector: NM_004797  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004797 UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Function : Important adipokine involved in the control of fat metabolism and insulin sensitivity,with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPKphosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilizationand fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression invarious tissues such as liver and macrophages, and also by counteracting its effects. Inhibitsendothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth,angiogenesis and tissue remodeling by binding and sequestering various growth factors withdistinct binding affinities, depending on the type of complex, LMW, MMW or HMW
15/18 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Adipoq) (see all 18
):4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ADIPOQ
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADIPOQ (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for ADIPOQ 5/94 Interacting proteins for ADIPOQ (ENSP00000320709 3 ) via UniProtKB, MINT, and/or STRING (see all 94
)About this table 5/27 Gene Ontology (GO) biological process terms (links to tree view) (see all 27
):
GO ID Qualified GO term Evidence PubMed IDs GO:0006006 glucose metabolic process
IEA -- GO:0006091 generation of precursor metabolites and energy
TAS 10095105 GO:0006635 fatty acid beta-oxidation
IEA -- GO:0009749 response to glucose stimulus
IEA -- GO:0009967 positive regulation of signal transduction
IEA --
About this table
Drugs & Compounds for ADIPOQ (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ADIPOQ UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Pharmaceutical : Adiponectin might be used in the treatment of diabetes type 2 and insulinresistance 10/40 Novoseek chemical compound relationships for ADIPOQ gene (see all 40
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
glucose
86.21
1101
16580118 (9), 16236252 (6), 17706206 (6), 17418606 (6) (see all 99 )
cholesterol
77.30
459
16793964 (4), 16574896 (4), 18063927 (4), 12796280 (3) (see all 99 )
lipid
76.55
412
15543224 (5), 12660875 (4), 16571847 (4), 16307747 (4) (see all 99 )
rimonabant
74.04
40
19211723 (5), 18951999 (3), 18426513 (1), 18457636 (1) (see all 24 )
nash
71.76
59
16231364 (5), 18923878 (4), 15718867 (4), 18311774 (3) (see all 22 )
fatty acid
66.51
142
17173081 (5), 16936205 (4), 15637134 (3), 15380884 (3) (see all 99 )
c-peptide
64.59
52
15168020 (3), 16308131 (2), 17938644 (2), 18330696 (2) (see all 40 )
sulfonylurea
53.87
9
18514142 (2), 18455831 (1), 18507868 (1), 19279518 (1) (see all 5 )
acadesine
51.22
3
18047638 (1), 14500570 (1), 17173081 (1)
triacylglycerol
43.36
27
18491071 (3), 19066306 (3), 16600927 (2), 17656596 (2) (see all 14 )
About this table
Transcripts for ADIPOQ(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004797 Sigma-Aldrich siRNA for ADIPOQ Sigma-Aldrich shRNA for ADIPOQ Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004797
REFSEQ mRNAs for ADIPOQ gene: NM_004797.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004797
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004797                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004797                                  untagged cDNA clone in CMV expression vector: NM_004797  
Additional cDNA sequence: AK291525.1 AK312868.1 AL832470.1 BC054496.1 BC096308.3 BC096309.3 BC096310.3 BC096311.3 D45371.1 EU420013.1
4 DOTS entries : DT.95360042 DT.97786567 DT.100659899 DT.101966091
24/45 AceView cDNA sequences (see all 45
):NM_004797 CD514622 BX282473 CD515608 CB266525 CD516758 AU121917 CB265535 CB265759 BQ889392 BQ876848 CB270806 AA339798 BQ717765 AL832470 AX767959 D45371 CD104471 CD516223 CB999000 AA321105 H16116 F16273 CD244690
highest scoring ESTs for ADIPOQ :D45371 AA339798 AL599686 AL691885 AU121917 BC054496 BQ326668 BQ717765 BQ876848 CB265535
Unigene Cluster for ADIPOQ: Adiponectin, C1Q and collagen domain containing Hs.80485 [show with all ESTs ] Unigene Representative Sequence: NM_004797 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b SP1 :             SP2 :     -        
About this scheme ECgene alternative splicing isoforms for ADIPOQ 1 Ensembl transcript including schematic representation : ENST00000320741
Expression for ADIPOQ
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ADIPOQ expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ADIPOQ 1 / 2 / 3
5 probe-sets matching ADIPOQ gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAGTTGGGTASOURCE GeneReport for Unigene cluster: Hs.80485 Expression variation in blood from EXPOLDB for ADIPOQ
UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Tissue specificity : Synthesized exclusively by adipocytes and secreted into plasma
Orthologs for ADIPOQ
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ADIPOQ gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ADIPOQ ENSEMBL Gene Tree for ADIPOQ Paralogs for ADIPOQ (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ADIPOQ gene ENSG00000205863 2 C1QTNF9 2
SNPs/Variants for ADIPOQ (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848 Polymorphism : Genetic variations in ADIPOQ influence the variance in adiponectin serum levels anddefine the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]
HapMap Linkage Disequilibrium images for ADIPOQ (up to first 250kb)
Disorders & Mutations for ADIPOQ
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605441 disorders : 612556 UniProtKB/Swiss-Prot: ADIPO_HUMAN, Q15848
Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPNDresults in very low concentrations of plasma adiponectin Genetic variations in ADIPOQ are associated with non-insulin-dependent diabetes mellitus(NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by anautosomal dominant mode of inheritance, onset during adulthood and insulin resistance
10/96 Novoseek disease relationships for ADIPOQ gene (see all 96
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance
94.91
1160
15292306 (6), 12574192 (5), 18253163 (5), 17276175 (5) (see all 99 )
insulin sensitivity
93.89
821
16373895 (7), 19107128 (7), 19037660 (6), 15627868 (6) (see all 99 )
obesity
90.20
674
12436346 (4), 18651432 (4), 15843989 (4), 17212015 (3) (see all 99 )
cardiovascular diseases
79.38
200
18027814 (5), 17253436 (3), 16581078 (3), 19389061 (3) (see all 99 )
fatty liver
77.82
55
17022944 (3), 15793855 (2), 17006986 (2), 18376369 (2) (see all 40 )
atherosclerosis
77.54
217
16886584 (4), 19238157 (3), 15928248 (3), 17276175 (3) (see all 99 )
dyslipidemia
77.31
32
17714716 (2), 16556684 (2), 15798954 (1), 16799399 (1) (see all 29 )
hyperinsulinemia
75.99
59
12611609 (2), 12660877 (2), 15862282 (1), 16718631 (1) (see all 52 )
lipodystrophy
75.68
27
12713059 (4), 12574192 (2), 14738456 (2), 17940113 (2) (see all 17 )
niddm
75.14
83
18027814 (4), 17046560 (3), 17445536 (3), 17890872 (2) (see all 61 )
About this table Human Gene Mutation Database : ADIPOQ Genetic Association Database: ADIPOQ Human Genome Epidemiology Navigator: ADIPOQ (157 documents)
Medical News for ADIPOQ (Possibly Related Articles in
Doctor's Guide )
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Publications for ADIPOQ (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/2325 PubMed articles for ADIPOQ gene (see all 2325
): Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. (PubMed id 12086969) 3, 4, 6 Kondo H....Matsuzawa Y. (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (PubMed id 11812766) 3, 4, 6 Hara K.... Kadowaki T. (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. (PubMed id 12354786) 3, 4, 6 Vasseur F.... Froguel P. (2002) Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. (PubMed id 12878598) 1, 3, 4 Waki H.... Kadowaki T. (2003) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (PubMed id 10982546) 1, 3, 4 Ouchi N.... Matsuzawa Y. (2000) Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity: a family-based association study. (PubMed id 12827242) 1, 3, 6 Yang W.S....Chuang L.M. (2003) Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. (PubMed id 15047634) 1, 3, 6 Fumeron F....Marre M. (2004) The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. (PubMed id 16324920) 1, 3, 6 Jang Y....Ordovas J.M. (2006) Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. (PubMed id 16254197) 1, 3, 6 Gonzalez-Sanchez J.L....Serrano-Rios M. (2006) Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men. (PubMed id 15547300) 1, 3, 6 Berthier M.T....Vohl M.C. (2005)
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Wikipedia http://en.wikipedia.org/wiki/Adiponectin
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-- Services for ADIPOQ (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Antibodies & Assays for ADIPOQ   (Adiponectin)
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