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ADIG Gene

protein-coding   GIFtS: 39
GCID: GC20P037209

Adipogenin

(Previous name: adipogenesis associated)
  Search for ADIG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
adipogenin1 2
Adipogenesis Associated1 2
SMAF12 5
Small Adipocyte Factor 11
RP5-1100H13.22
Small Adipocyte Factor 1 (SMAF1)2

External Ids:    HGNC: 286061   Entrez Gene: 1496852   Ensembl: ENSG000001820357   OMIM: 6113965   UniProtKB: Q0VDE83   

Export aliases for ADIG gene to outside databases

Previous GC identifers: GC20P036645 GC20P033946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADIG Gene:
ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005
(PubMed 15567149); Hong et al., 2005 (PubMed 16132694)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ADIG Gene:
ADIG (adipogenin) is a protein-coding gene.

UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8
Function: Plays a role in stimulating adipocyte differentiation and development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADIG gene promoter:
         STAT1   STAT4   SREBP-1c   STAT1beta   STAT5A   STAT1alpha   SREBP-1b   SREBP-1a   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADIG promoter sequence
   Search Chromatin IP Primers for ADIG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

ADIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIG gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037209:  view genomic region     (about GC identifiers)

Start:
37,209,838 bp from pter      End:
37,217,106 bp from pter
Size:
7,269 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8 (See protein sequence)
Recommended Name: Adipogenin  
Size: 80 amino acids; 9465 Da

Explore the universe of human proteins at neXtProt for ADIG: NX_Q0VDE8

Explore proteomics data for ADIG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADIG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001018092.1  
    ENSEMBL proteins: 
     ENSP00000434385   ENSP00000362445   ENSP00000416834   ENSP00000440331  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027938 Adipogenin

    Graphical View of Domain Structure for InterPro Entry Q0VDE8

    ProtoNet protein and cluster: Q0VDE8

    UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8
    Similarity: Belongs to the adipogenin family


    ADIG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADIG_HUMAN, Q0VDE8
    Function: Plays a role in stimulating adipocyte differentiation and development (By similarity)

    Phenotypes:
         1 MGI phenotypic allele for Adig (no phenotypes)


    ADIG for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-mir-335-5p (MIRT017353)

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    hsa-miR-345 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidADIG 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADIG_HUMAN, Q0VDE8: Membrane; Single-pass membrane protein (Potential). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    nucleus3
    cytosol1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS15567149
    GO:0005737cytoplasm ISS15567149
    GO:0016021integral component of membrane IEA--

    ADIG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ADIG: 
              Adipogenesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADIG

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis IEA--
    GO:0045444fat cell differentiation ----
    GO:0045600positive regulation of fat cell differentiation ISS15567149
    GO:0050872white fat cell differentiation ISS15567149
    GO:0050873brown fat cell differentiation ISS15567149

    ADIG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ADIG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADIG gene (2 alternative transcripts): 
    NM_174906.3  NM_001018082.1  

    Unigene Cluster for ADIG:

    Adipogenin
    Hs.368028  [show with all ESTs]
    Unigene Representative Sequence: BC029594
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470147(uc002xjb.1) ENST00000373348 ENST00000416116 ENST00000537425

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    hsa-miR-345 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidADIG 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC029594.1 BC119704.2 BC119705.2 

    3 DOTS entries:

    DT.95356617  DT.305634  DT.40207905 

    11 AceView cDNA sequences:

    BX102042 AI656415 AA974242 BX105371 BC029594 AI990489 AI632573 NM_174906 
    BI461854 AA776833 AA972215 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADIG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGAAATT
    ADIG Expression
    About this image


    ADIG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
    ADIG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADIG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368028
        Pathway & Disease-focused RT2 Profiler PCR Array including ADIG: 
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADIG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ADIG gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adig5 adipogenin   --   2 (78.72 cM) 158502612 


    ENSEMBL Gene Tree for ADIG (if available)
    TreeFam Gene Tree for ADIG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADIG (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916837141,2
    --37208067(+) CTGCCA/TACCTT 1 -- us2k10--------
    rs60266371,2
    H--37208110(+) CAACAG/AGACCT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1381395021,2
    C--37208157(+) AGTAGA/CCCTGT 1 -- us2k10--------
    rs1145692021,2
    C,F--37208271(+) CAGTTC/ACAGGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs61003001,2
    C,F--37208310(+) CTCCTT/CCTCTT 1 -- us2k1 trp32Minor allele frequency- C:0.25CSA WA 120
    rs1435785611,2
    --37208375(+) ACTCAC/TTCTAG 1 -- us2k10--------
    rs786944971,2
    C,F--37208439(+) TAGGAC/TTCTTG 1 -- us2k12Minor allele frequency- T:0.13WA 120
    rs60647331,2
    C,F,A,H--37208527(+) GAATCA/GGTGTC 1 -- us2k119Minor allele frequency- G:0.40NS EA NA WA 2340
    rs1139417371,2
    C,F--37208585(+) CACCCG/CCTTCC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs730999081,2
    --37208586(+) ACCCCC/GTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADIG (37209838 - 37217106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADIG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3372CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ADIG
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611396    OMIM disorders: --


    ADIG for disorders           About GeneDecksing


    Export disorders for ADIG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADIG gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ADIG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (PubMed id 16132694)1, 3 Hong Y.H....Sasaki S. (Mol. Cell. Biochem. 2005)
    2. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. (PubMed id 15567149)1, 3 Kim J.Y....Smas C.M. (Biochem. Biophys. Res. Commun. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149685 HGNC: 28606 AceView: MGC39724 Ensembl:ENSG00000182035 euGenes: HUgn149685
    ECgene: ADIG H-InvDB: ADIG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADIG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADIG gene:
    Search GeneIP for patents involving ADIG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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