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Aliases for ADIG Gene

Aliases for ADIG Gene

  • Adipogenin 2 3 5
  • Adipogenesis Associated 2 3
  • Small Adipocyte Factor 1 (SMAF1) 3
  • Small Adipocyte Factor 1 2
  • SMAF1 3

External Ids for ADIG Gene

Previous GeneCards Identifiers for ADIG Gene

  • GC20P036645
  • GC20P037209
  • GC20P033946

Summaries for ADIG Gene

Entrez Gene Summary for ADIG Gene

  • ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIG Gene

ADIG (Adipogenin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ADIG Gene

  • Plays a role in stimulating adipocyte differentiation and development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIG Gene

Genomics for ADIG Gene

Regulatory Elements for ADIG Gene

Genomic Location for ADIG Gene

Chromosome:
20
Start:
38,581,195 bp from pter
End:
38,588,463 bp from pter
Size:
7,269 bases
Orientation:
Plus strand

Genomic View for ADIG Gene

Genes around ADIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIG Gene

Proteins for ADIG Gene

  • Protein details for ADIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDE8-ADIG_HUMAN
    Recommended name:
    Adipogenin
    Protein Accession:
    Q0VDE8

    Protein attributes for ADIG Gene

    Size:
    80 amino acids
    Molecular mass:
    9465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIG Gene

Proteomics data for ADIG Gene at MOPED

Post-translational modifications for ADIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIG Gene

No data available for DME Specific Peptides for ADIG Gene

Domains & Families for ADIG Gene

Protein Domains for ADIG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADIG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VDE8

UniProtKB/Swiss-Prot:

ADIG_HUMAN :
  • Belongs to the adipogenin family.
Family:
  • Belongs to the adipogenin family.
genes like me logo Genes that share domains with ADIG: view

No data available for Gene Families for ADIG Gene

Function for ADIG Gene

Molecular function for ADIG Gene

UniProtKB/Swiss-Prot Function:
Plays a role in stimulating adipocyte differentiation and development.
genes like me logo Genes that share phenotypes with ADIG: view

Animal Model Products

miRNA for ADIG Gene

miRTarBase miRNAs that target ADIG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADIG Gene

Localization for ADIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIG Gene

Membrane; Single-pass membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIG Gene COMPARTMENTS Subcellular localization image for ADIG gene
Compartment Confidence
extracellular 3
nucleus 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADIG: view

Pathways & Interactions for ADIG Gene

SuperPathways for ADIG Gene

No Data Available

Interacting Proteins for ADIG Gene

Gene Ontology (GO) - Biological Process for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045444 fat cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation IEA,ISS 15567149
GO:0050872 white fat cell differentiation IEA,ISS 15567149
GO:0050873 brown fat cell differentiation IEA,ISS 15567149
genes like me logo Genes that share ontologies with ADIG: view

No data available for Pathways by source and SIGNOR curated interactions for ADIG Gene

Drugs & Compounds for ADIG Gene

No Compound Related Data Available

Transcripts for ADIG Gene

mRNA/cDNA for ADIG Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADIG Gene

Adipogenin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADIG Gene

No ASD Table

Relevant External Links for ADIG Gene

GeneLoc Exon Structure for
ADIG
ECgene alternative splicing isoforms for
ADIG

Expression for ADIG Gene

mRNA expression in normal human tissues for ADIG Gene

mRNA differential expression in normal tissues according to GTEx for ADIG Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for ADIG Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADIG Gene



SOURCE GeneReport for Unigene cluster for ADIG Gene Hs.368028

genes like me logo Genes that share expression patterns with ADIG: view

Protein tissue co-expression partners for ADIG Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADIG Gene

Orthologs for ADIG Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADIG 35
  • 82.7 (n)
  • 78.48 (a)
ADIG 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIG 35
  • 85 (n)
  • 81.25 (a)
chimpanzee
(Pan troglodytes)
Mammalia ADIG 35
  • 98.75 (n)
  • 98.75 (a)
ADIG 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911217 35
  • 78.79 (n)
  • 68.83 (a)
mouse
(Mus musculus)
Mammalia Adig 36
  • 61 (a)
OneToOne
Species with no ortholog for ADIG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIG Gene

ENSEMBL:
Gene Tree for ADIG (if available)
TreeFam:
Gene Tree for ADIG (if available)

Paralogs for ADIG Gene

No data available for Paralogs for ADIG Gene

Variants for ADIG Gene

Sequence variations from dbSNP and Humsavar for ADIG Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1033516 -- 38,580,343(-) GAACA(C/T)TTCCA upstream-variant-2KB
rs3171210 -- 38,588,455(+) CCCTG(A/C)CAAAC nc-transcript-variant, utr-variant-3-prime
rs4812047 -- 38,580,863(+) TATGA(A/G)CACCG upstream-variant-2KB
rs4812050 -- 38,582,887(+) ATCTC(A/G)GCTCA intron-variant
rs6015420 -- 38,581,919(+) TGGCT(G/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADIG Gene

Variant ID Type Subtype PubMed ID
nsv3372 CNV Insertion 18451855

Variation tolerance for ADIG Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIG Gene

HapMap Linkage Disequilibrium report
ADIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIG Gene

Disorders for ADIG Gene

Relevant External Links for ADIG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIG

No disorders were found for ADIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADIG Gene

Publications for ADIG Gene

  1. Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (PMID: 16132694) Hong Y.H. … Sasaki S. (Mol. Cell. Biochem. 2005) 2 3 67
  2. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. (PMID: 15567149) Kim J.Y. … Smas C.M. (Biochem. Biophys. Res. Commun. 2005) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ADIG Gene

Sources for ADIG Gene

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