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Aliases for ADIG Gene

Aliases for ADIG Gene

  • Adipogenin 2 3 3 5
  • Adipogenesis Associated 2 3
  • Small Adipocyte Factor 1 (SMAF1) 3
  • Small Adipocyte Factor 1 2
  • SMAF1 3

External Ids for ADIG Gene

Previous GeneCards Identifiers for ADIG Gene

  • GC20P036645
  • GC20P037209
  • GC20P033946

Summaries for ADIG Gene

Entrez Gene Summary for ADIG Gene

  • ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ADIG Gene

ADIG (Adipogenin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ADIG Gene

  • Plays a role in stimulating adipocyte differentiation and development.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIG Gene

Genomics for ADIG Gene

Regulatory Elements for ADIG Gene

Enhancers for ADIG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G038604 1 ENCODE 11.5 +23.9 23898 0.3 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 FOS PAF1 ADIG ARHGAP40 LOC391247
GH20G038536 0.5 ENCODE 10.8 -44.6 -44586 1.2 CTCF ZNF316 ZNF146 PRDM4 ADIG ARHGAP40 ENSG00000224635 RPS3P2 MIR548O2
GH20G038600 1.5 FANTOM5 Ensembl ENCODE 0.3 +20.4 20395 1.2 ARID4B KLF17 RAD21 EGR1 SCRT2 EGR2 SP3 ZNF398 ZNF341 ZNF580 ARHGAP40 ADIG
GH20G038572 0.8 ENCODE 0.4 -7.3 -7301 1.8 CTCF FOXA2 MXI1 SAP130 SIN3A INSM2 DNMT3B RAD21 TEAD3 FOSL1 SNHG17 SNORA71A SNORA71B SNHG11 SNORA60 ENSG00000201811 SNORA71D SNORA71C ENSG00000224635 ARHGAP40
GH20G038598 0.8 ENCODE 0.4 +18.2 18233 1.2 ELF3 NFIB RBBP5 ZIC2 ZNF644 ZNF48 TEAD3 ZNF121 GLIS2 ELK1 ARHGAP40 ADIG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADIG on UCSC Golden Path with GeneCards custom track

Genomic Location for ADIG Gene

Chromosome:
20
Start:
38,581,195 bp from pter
End:
38,588,463 bp from pter
Size:
7,269 bases
Orientation:
Plus strand

Genomic View for ADIG Gene

Genes around ADIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIG Gene

Proteins for ADIG Gene

  • Protein details for ADIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDE8-ADIG_HUMAN
    Recommended name:
    Adipogenin
    Protein Accession:
    Q0VDE8

    Protein attributes for ADIG Gene

    Size:
    80 amino acids
    Molecular mass:
    9465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADIG Gene

Post-translational modifications for ADIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADIG Gene

No data available for DME Specific Peptides for ADIG Gene

Domains & Families for ADIG Gene

Protein Domains for ADIG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADIG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VDE8

UniProtKB/Swiss-Prot:

ADIG_HUMAN :
  • Belongs to the adipogenin family.
Family:
  • Belongs to the adipogenin family.
genes like me logo Genes that share domains with ADIG: view

No data available for Gene Families for ADIG Gene

Function for ADIG Gene

Molecular function for ADIG Gene

UniProtKB/Swiss-Prot Function:
Plays a role in stimulating adipocyte differentiation and development.
genes like me logo Genes that share phenotypes with ADIG: view

Animal Model Products

miRNA for ADIG Gene

miRTarBase miRNAs that target ADIG

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADIG Gene

Localization for ADIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIG Gene

Membrane; Single-pass membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADIG gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 15567149
GO:0005737 cytoplasm ISS 15567149
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADIG: view

Pathways & Interactions for ADIG Gene

No Data Available

Interacting Proteins for ADIG Gene

Gene Ontology (GO) - Biological Process for ADIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0045444 fat cell differentiation IEA --
GO:0045600 positive regulation of fat cell differentiation ISS 15567149
GO:0050872 white fat cell differentiation ISS 15567149
GO:0050873 brown fat cell differentiation ISS 15567149
genes like me logo Genes that share ontologies with ADIG: view

No data available for Pathways by source and SIGNOR curated interactions for ADIG Gene

Drugs & Compounds for ADIG Gene

No Compound Related Data Available

Transcripts for ADIG Gene

mRNA/cDNA for ADIG Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADIG Gene

Adipogenin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADIG Gene

No ASD Table

Relevant External Links for ADIG Gene

GeneLoc Exon Structure for
ADIG
ECgene alternative splicing isoforms for
ADIG

Expression for ADIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADIG Gene

mRNA differential expression in normal tissues according to GTEx for ADIG Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for ADIG Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADIG Gene



Protein tissue co-expression partners for ADIG Gene

NURSA nuclear receptor signaling pathways regulating expression of ADIG Gene:

ADIG

SOURCE GeneReport for Unigene cluster for ADIG Gene:

Hs.368028
genes like me logo Genes that share expression patterns with ADIG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADIG Gene

Orthologs for ADIG Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADIG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIG 34 35
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia ADIG 34
  • 85 (n)
cow
(Bos Taurus)
Mammalia ADIG 34 35
  • 82.7 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911217 34
  • 78.79 (n)
mouse
(Mus musculus)
Mammalia Adig 35
  • 61 (a)
OneToOne
Species where no ortholog for ADIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADIG Gene

ENSEMBL:
Gene Tree for ADIG (if available)
TreeFam:
Gene Tree for ADIG (if available)

Paralogs for ADIG Gene

No data available for Paralogs for ADIG Gene

Variants for ADIG Gene

Sequence variations from dbSNP and Humsavar for ADIG Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000540364 -- 38,584,031(+) TTTGC(C/T)TGAAA intron-variant
rs1001472540 -- 38,584,444(+) TGGGG(C/T)TGAAA intron-variant
rs1001652478 -- 38,580,312(+) ATGAC(-/AGAT)AGGAG upstream-variant-2KB
rs1001808115 -- 38,583,025(+) GTTAG(C/T)CAGGC intron-variant
rs1002041950 -- 38,581,851(+) CTTAG(A/G)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADIG Gene

Variant ID Type Subtype PubMed ID
nsv1058457 CNV loss 25217958
nsv3372 CNV insertion 18451855

Variation tolerance for ADIG Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADIG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADIG Gene

Disorders for ADIG Gene

Relevant External Links for ADIG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADIG

No disorders were found for ADIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADIG Gene

Publications for ADIG Gene

  1. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. (PMID: 15567149) Kim J.Y. … Smas C.M. (Biochem. Biophys. Res. Commun. 2005) 2 3 64
  2. Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (PMID: 16132694) Hong Y.H. … Sasaki S. (Mol. Cell. Biochem. 2005) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4 64

Products for ADIG Gene

Sources for ADIG Gene

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