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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADIG Gene

protein-coding   GIFtS: 38
GCID: GC20P037209

adipogenin

(Previous name: adipogenesis associated )
  Search for ADIG
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADIG    

Aliases
for ADIG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adipogenin1
SMAF11 2
Adipogenesis Associated1 2
MGC397241
RP5-1100H13.21
Small Adipocyte Factor 1 (SMAF1)2

External Ids:    HGNC: 286061   Entrez Gene: 1496852   Ensembl: ENSG000001820357   OMIM: 6113965   UniProtKB: Q0VDE83   

Export aliases for ADIG gene to outside databases

Previous GC identifers: GC20P036645 GC20P033946


Summaries
for ADIG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADIG:
ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 (PubMed
15567149); Hong et al., 2005 (PubMed 16132694)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8
Function: Plays a role in stimulating adipocyte differentiation and development (By similarity)




Genomic Views
for ADIG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADIG gene promoter:
         STAT1   STAT4   SREBP-1c   STAT1beta   STAT5A   STAT1alpha   SREBP-1b   SREBP-1a   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADIG promoter sequence
   Search SABiosciences Chromatin IP Primers for ADIG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

ADIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADIG gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037209:  view genomic region     (about GC identifiers)

Start:
 37,209,838 bp from pter      End:
 37,217,106 bp from pter
Size:
 7,269 bases      Orientation:
 plus strand

Proteins
for ADIG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8 (See protein sequence)
Recommended Name: Adipogenin  
Size: 80 amino acids; 9465 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ADIG: NX_Q0VDE8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0VDE8

    • ADIG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001018092.1  
    ENSEMBL proteins: 
     ENSP00000434385   ENSP00000362445   ENSP00000416834   ENSP00000440331  

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    Uscn Proteins for ADIG

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS15567149
    GO:0005737cytoplasm ISS15567149
    GO:0016021integral to membrane IEA--


    ADIG for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADIG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0VDE8

    UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8
    Similarity: Belongs to the adipogenin family


    Function
    for ADIG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADIG_HUMAN, Q0VDE8
    Function: Plays a role in stimulating adipocyte differentiation and development (By similarity)

    miRNA
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    Inhib. RNA
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    Pathways & Interactions
    for ADIG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADIG

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis IEA--
    GO:0045600positive regulation of fat cell differentiation ISS15567149
    GO:0050872white fat cell differentiation ISS15567149
    GO:0050873brown fat cell differentiation ISS15567149


    ADIG for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADIG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADIG
    Search CenterWatch for drugs/clinical trials and news about ADIG 

    Transcripts
    for ADIG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADIG gene (2 alternative transcripts): 
    NM_174906.3  NM_001018082.1  

    Unigene Cluster for ADIG:

    Adipogenin
    Hs.368028  [show with all ESTs]
    Unigene Representative Sequence: BC029594
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470147(uc002xjb.1) ENST00000373348 ENST00000416116 ENST00000537425


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    hsa-miR-345 hsa-miR-508-5p
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    BC029594.1 BC119704.2 BC119705.2 

    3 DOTS entries:

    DT.95356617  DT.305634  DT.40207905 

    11 AceView cDNA sequences:

    AI656415 AA974242 BX105371 BX102042 AI990489 NM_174906 BC029594 AI632573 
    AA776833 BI461854 AA972215 

    GeneLoc Exon Structure


    Expression
    for ADIG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADIG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAGAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADIG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADIG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADIG

    SOURCE GeneReport for Unigene cluster: Hs.368028
        SABiosciences Expression via Pathway-Focused PCR Array including ADIG: 
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ADIG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for ADIG gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Adig1 , 5 adipogenin1, 5 80.18(n)1
    66.22(a)1    		   2 (78.72 cM)5
    2467471  NM_145635.21  NP_663610.11 
     1585026125 


    ENSEMBL Gene Tree for ADIG (if available)
    TreeFam Gene Tree for ADIG (if available) 

    Paralogs
    for ADIG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ADIG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 NCBI SNPs in ADIG are shown (see all 187)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1916837141,2
    		--37208067(+) CTGCCA/TACCTT 1 -- us2k10--------
    rs60266371,2
    		H--37208110(+) CAACAG/AGACCT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1381395021,2
    		--37208157(+) AGTAGA/CCCTGT 1 -- us2k10--------
    rs1145692021,2
    		F,--37208271(+) CAGTTC/ACAGGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs61003001,2
    		C,--37208310(+) CTCCTT/CCTCTT 1 -- us2k1 trp32Minor allele frequency- C:0.25CSA WA 120
    rs1435785611,2
    		--37208375(+) ACTCAC/TTCTAG 1 -- us2k10--------
    rs786944971,2
    		C,--37208439(+) TAGGAC/TTCTTG 1 -- us2k12Minor allele frequency- T:0.13WA 120
    rs60647331,2
    		C,F,A,H,--37208527(+) GAATCA/GGTGTC 1 -- us2k119Minor allele frequency- G:0.40NS EA NA WA 2340
    rs1139417371,2
    		--37208585(+) CACCCG/CCTTCC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs730999081,2
    		--37208586(+) ACCCCC/GTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADIG (37209838 - 37217106 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADIG: --

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    Disorders / Diseases
    for ADIG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADIG for disorders           About MalaCards

    ADIG for disorders           About GeneDecksing

    OMIM gene information: 611396    OMIM disorders: --


    Export disorders for ADIG gene to outside databases

    Publications
    for ADIG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADIG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADIG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Up-regulation of adipogenin, an adipocyte plasma tran smembrane protein, during adipogenesis. (PubMed id 16132694)1, 3 Hong Y.H....Sasaki S. (2005)
    2. Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. (PubMed id 15567149)1, 3 Kim J.Y....Smas C.M. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)

    External Searches for ADIG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADIG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149685 HGNC: 28606 AceView: MGC39724 Ensembl:ENSG00000182035 euGenes: HUgn149685
    ECgene: ADIG H-InvDB: ADIG

    Other Databases showing ADIG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADIG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADIG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADIG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADIG gene:
    Search GeneIP for patents involving ADIG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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