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ADI1 Gene

protein-coding   GIFtS: 57
GCID: GC02M003501

Acireductone Dioxygenase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acireductone Dioxygenase 11 2     Ni-ARD2
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding
Protein-11 2
     Acireductone Dioxygenase (Ni(2+)-Requiring)2
Acireductone Dioxygenase (Fe(2+)-Requiring)2 3     MT1-MMP Cytoplasmic Tail-Binding Protein-12
Submergence-Induced Protein-Like Factor2 3     mtnD2
ARD2 3     Submergence Induced Protein 22
Fe-ARD2 3     EC 1.13.11.543
MTCBP12 3     MTCBP-13
SIPL2 5     Sip-L3
1,2-Dihydroxy-3-Keto-5-Methylthiopentene Dioxygenase2     Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein
13
APL12     

External Ids:    HGNC: 305761   Entrez Gene: 552562   Ensembl: ENSG000001825517   OMIM: 6134005   UniProtKB: Q9BV573   

Export aliases for ADI1 gene to outside databases

Previous GC identifer: GC02M003480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADI1 Gene:
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which
are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out
different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20.
(provided by RefSeq, May 2010)

GeneCards Summary for ADI1 Gene:
ADI1 (acireductone dioxygenase 1) is a protein-coding gene. GO annotations related to this gene include acireductone dioxygenase [iron(II)-requiring] activity and iron ion binding.

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57
Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from
1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Necessary for hepatitis C virus replication in an otherwise non-permissive cell line

Gene Wiki entry for ADI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005334.17  NC_018913.2  NT_187522.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADI1 gene promoter:
         USF1   C/EBPbeta   USF2   USF-1:USF-2   POU6F1 (c2)   Cdc5   POU2F1   POU2F1a   USF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADI1 promoter sequence
   Search Chromatin IP Primers for ADI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.2

ADI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADI1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M003501:  view genomic region     (about GC identifiers)

Start:
3,501,132 bp from pter      End:
3,523,507 bp from pter
Size:
22,376 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57 (See protein sequence)
Recommended Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase  
Size: 179 amino acids; 21498 Da
Cofactor: Binds 1 iron ion per monomer. Can also use other divalent metal cations (By similarity)
Subunit: Monomer (By similarity). Interacts with MMP14
Sequence caution: Sequence=AAL25800.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD38646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD96187.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W4Y3 Q53HW3 Q53QD3 Q57YV7 Q68CK2 Q6ZSF7 Q7Z512 Q96P85 Q9NV57
Alternative splicing: 2 isoforms:  Q9BV57-1   Q9BV57-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADI1: NX_Q9BV57

Explore proteomics data for ADI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060739.2  
    ENSEMBL proteins: 
     ENSP00000333666   ENSP00000371525   ENSP00000410178  
    Reactome Protein details: Q9BV57

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027496 MTCBP-1_eukaryotes
     IPR011051 RmlC_Cupin
     IPR004313 Acireductn_dOase_family
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q9BV57

    ProtoNet protein and cluster: Q9BV57

    UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57
    Similarity: Belongs to the acireductone dioxygenase (ARD) family


    Find genes that share domains with ADI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTND_HUMAN, Q9BV57
    Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from
    1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
    Necessary for hepatitis C virus replication in an otherwise non-permissive cell line
    Catalytic activity: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate

         Enzyme Number (IUBMB): EC 1.13.11.541

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI14718544
    GO:0010309acireductone dioxygenase [iron(II)-requiring] activity TAS--
    GO:0016491oxidoreductase activity IDA15938715
         
    Find genes that share ontologies with ADI1           About GenesLikeMe


    Animal Models:
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    hsa-mir-26b-5p (MIRT029129), hsa-mir-193b-3p (MIRT016389)

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    4 qRT-PCR Assays for microRNAs that regulate ADI1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidADI1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTND_HUMAN, Q9BV57: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Localizes to the plasma membrane when complexed to MMP14
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    golgi apparatus4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA11602742
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ADI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Methionine salvage pathway0.00
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.00
    Metabolism of amino acids and derivatives
    methylthiopropionate biosynthesis0.00
    Metabolism of polyamines0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35


    Find genes that share SuperPaths with ADI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ADI1
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I
    methylthiopropionate biosynthesis


    1 Reactome Pathway for ADI1
        Methionine salvage pathway


    2 Kegg Pathways  (Kegg details for ADI1):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6

        Pathway & Disease-focused RT2 Profiler PCR Array including ADI1: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ADI1 (Q9BV571, 3 ENSP000003336664) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502811, 3, ENSP000003082084EBI-992807,EBI-992788 I2D: score=2 STRING: ENSP00000308208
    DBTP111823, ENSP000003591514I2D: score=2 STRING: ENSP00000359151
    ENOPH1Q9UHY73, ENSP000002739204I2D: score=1 STRING: ENSP00000273920
    OSTF1Q928823, ENSP000003408364I2D: score=2 STRING: ENSP00000340836
    DENRO435833I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006595polyamine metabolic process TAS--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    Find genes that share ontologies with ADI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADI1 (MTND)

    1 HMDB Compound for ADI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    NickelCarbonyl nickel powder (see all 19)7440-02-0--

    5 Novoseek inferred chemical compound relationships for ADI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine 50.2 7 17786183 (1), 18237192 (1), 17212658 (1), 14718544 (1)
    fe2+ 48.6 4 16989860 (3)
    carboxylate 48.3 3 17288413 (2), 17645333 (1)
    oxygen 14.5 3 18237192 (1)
    hydrogen 7.01 2 17645333 (1), 17288413 (1)



    Find genes that share compounds with ADI1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADI1 gene: 
    NM_018269.3  

    Unigene Cluster for ADI1:

    Acireductone dioxygenase 1
    Hs.502773  [show with all ESTs]
    Unigene Representative Sequence: AK127473
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327435(uc002qxp.4) ENST00000382093(uc010yiq.2) ENST00000415131

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    hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidADI1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ADI1

    Additional mRNA sequence: 

    AB073609.1 AB158319.1 AF087863.1 AF403478.1 AK001775.1 AK127473.1 AK222467.1 AK225278.1 
    BC001467.2 

    21 DOTS entries:

    DT.446852  DT.99956085  DT.101985071  DT.92451152  DT.99988886  DT.100827485  DT.100827486  DT.100827475 
    DT.100827480  DT.97794559  DT.100700644  DT.100827474  DT.100827495  DT.120990091  DT.91832014  DT.92451148 
    DT.92451149  DT.95256744  DT.95256759  DT.100827487  DT.75162181 

    Selected AceView cDNA sequences (see all 493):

    AA360213 AI476741 CK819995 CR592882 AI458820 BQ005756 CR603459 T35686 
    AI300683 CR598608 BQ225593 BM680542 BQ189020 AA594615 AL547323 AA314427 
    AA136668 BG776692 T36021 BE731218 T34519 CR604779 AV653144 CR593705 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADI1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:        -                             -                     
    SP2:                                                            
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for ADI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTGGAGTT
    ADI1 Expression
    About this image


    ADI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Prostate (Endocrine System)
    ADI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502773

    UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57
    Tissue specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including ADI1: 
              Amino Acid Metabolism I in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ADI1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADI1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adi11 , 5 acireductone dioxygenase 11, 5 84.54(n)1
    84.36(a)1
      12 (11.05 cM)5
    1049231  NM_134052.21  NP_598813.11 
     286752315 
    chicken
    (Gallus gallus)
    Aves ADI11 acireductone dioxygenase 1 73(n)
    78.21(a)
      421918  NM_001031089.1  NP_001026260.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADI16
    acireductone dioxygenase 1
    80(a)
    1 ↔ 1
    1(162371455-162381334)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adi11 acireductone dioxygenase 1 74.12(n)
    75.98(a)
      448325  NM_001004933.1  NP_001004933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059549.12   -- 74.53(n)   324079  BC059549.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG320681 CG32068 55.81(n)
    49.44(a)
      326189  NM_001104107.2  NP_001097577.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F42F12.46
    K07E1.16
    (see all 3)
    Protein K07E1.1 (K07E1.1) mRNA, complete cds
    (see all 3)
    38(a)
    35(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    X(12351978-12352977) WBGene00009636
    II(4550894-4552175) WBGene00019489
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADI1(YMR009W)4 Acireductone dioxygenease involved in the methionine more   --   13(284102-284641) 855021  NP_013722.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARD11 ARD1 62.02(n)
    62.79(a)
      827124  NM_117556.3  NP_567443.1 
    rice
    (Oryza sativa)
    Liliopsida NM_187765.12   -- 77.04(n)    NM_187765.1 


    ENSEMBL Gene Tree for ADI1 (if available)
    TreeFam Gene Tree for ADI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADI1 gene

    Find genes that share paralogs with ADI1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ADI1
    PGOHUM00000239760 PGOHUM00000244745 PGOHUM00000247657 PGOHUM00000249466


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADI1 (see all 624)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932841261,2
    --3501255(+) CTATTA/GTATGC 1 -- ds50010--------
    rs1505833081,2
    C--3501301(+) GTCTCA/GCTCTG 1 -- ds50010--------
    rs43983011,2
    C--3501356(+) GCCTCG/AACCTC 1 -- ds50015Minor allele frequency- A:0.18NA WA EA 362
    rs1394813971,2
    --3501514(+) GAGTCC/TGCAGG 1 -- ds50010--------
    rs1825263711,2
    C--3501531(+) GCCCCA/GCACGA 1 -- ds50010--------
    rs1880421211,2
    --3501535(+) CGCACA/GAGGAG 1 -- ds50010--------
    rs356742951,2
    C,F--3501567(+) ACAGGG/AAAAAG 1 -- ds50017Minor allele frequency- A:0.19NA CSA WA EA 366
    rs1441928491,2
    C--3501602(+) TAAAGA/C/TGATAG 1 -- ds50010--------
    rs739105751,2
    C--3501614(+) TTATCA/GTATGA 1 -- ds50014Minor allele frequency- G:0.19WA NA EA 360
    rs1473397571,2
    --3501620(+) TATGAA/GTGTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADI1 (3501132 - 3523507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4042n71CNV Loss21882294
    esv275511CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADI1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613400    OMIM disorders: --


    Find genes that share disorders with ADI1           About GenesLikeMe

    Genetic Association Database (GAD): ADI1
    Human Genome Epidemiology (HuGE) Navigator: ADI1 (1 document)

    Export disorders for ADI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADI1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ADI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors. (PubMed id 14718544)1, 2, 3, 9 Uekita T.... Seiki M. (J. Biol. Chem. 2004)
    2. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. (PubMed id 15938715)1, 2, 3 Hirano W.... Seiki M. (Genes Cells 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. (PubMed id 11602742)1, 2 Yeh C.-T.... Liaw Y.-F. (J. Virol. 2001)
    9. Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. (PubMed id 17786183)1, 9 Oram S.W....Wang Z. (Neoplasia 2007)
    10. 293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection. (PubMed id 19626614)1, 9 Cheng J.C....Yeh C.T. (J. Med. Virol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55256 HGNC: 30576 AceView: MTCBP-1 Ensembl:ENSG00000182551 euGenes: HUgn55256
    ECgene: ADI1 Kegg: 55256 H-InvDB: ADI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADI1 gene:
    Search GeneIP for patents involving ADI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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