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Aliases for ADI1 Gene

Aliases for ADI1 Gene

  • Acireductone Dioxygenase 1 2 3
  • Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding Protein-1 2 3
  • Acireductone Dioxygenase (Fe(2+)-Requiring) 3 4
  • Submergence-Induced Protein-Like Factor 3 4
  • MTCBP-1 3 4
  • Fe-ARD 3 4
  • MTCBP1 3 4
  • SIPL 3 6
  • ARD 3 4
  • Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 4
  • 1,2-Dihydroxy-3-Keto-5-Methylthiopentene Dioxygenase 3
  • Acireductone Dioxygenase (Ni(2+)-Requiring) 3
  • MT1-MMP Cytoplasmic Tail-Binding Protein-1 3
  • Submergence Induced Protein 2 3
  • EC 1.13.11.54 4
  • HMFT1638 3
  • Ni-ARD 3
  • Sip-L 4
  • APL1 3
  • MtnD 3

External Ids for ADI1 Gene

Summaries for ADI1 Gene

Entrez Gene Summary for ADI1 Gene

  • This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. [provided by RefSeq, May 2010]

GeneCards Summary for ADI1 Gene

ADI1 (Acireductone Dioxygenase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and acireductone dioxygenase [iron(II)-requiring] activity.

UniProtKB/Swiss-Prot for ADI1 Gene

  • Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Gene Wiki entry for ADI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADI1 Gene

Genomics for ADI1 Gene

Genomic Location for ADI1 Gene

Start:
3,497,361 bp from pter
End:
3,519,736 bp from pter
Size:
22,376 bases
Orientation:
Minus strand

Genomic View for ADI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADI1 Gene

Regulatory Elements for ADI1 Gene

Proteins for ADI1 Gene

  • Protein details for ADI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV57-MTND_HUMAN
    Recommended name:
    1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
    Protein Accession:
    Q9BV57
    Secondary Accessions:
    • D6W4Y3
    • Q53HW3
    • Q53QD3
    • Q57YV7
    • Q68CK2
    • Q6ZSF7
    • Q7Z512
    • Q96P85
    • Q9NV57

    Protein attributes for ADI1 Gene

    Size:
    179 amino acids
    Molecular mass:
    21498 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per monomer. Can also use other divalent metal cations.;
    Quaternary structure:
    • Monomer (By similarity). Interacts with MMP14.
    SequenceCaution:
    • Sequence=AAL25800.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96187.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADI1 Gene

Proteomics data for ADI1 Gene at MOPED

Post-translational modifications for ADI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADI1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADI1 Gene

Domains for ADI1 Gene

Protein Domains for ADI1 Gene

Suggested Antigen Peptide Sequences for ADI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV57

UniProtKB/Swiss-Prot:

MTND_HUMAN
Family:
  • Belongs to the acireductone dioxygenase (ARD) family.:
    • Q9BV57
genes like me logo Genes that share domains with ADI1: view

No data available for Gene Families for ADI1 Gene

Function for ADI1 Gene

Molecular function for ADI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate.
UniProtKB/Swiss-Prot Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Enzyme Numbers (IUBMB) for ADI1 Gene

Gene Ontology (GO) - Molecular Function for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 14718544
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity TAS --
GO:0016491 oxidoreductase activity IDA 15938715
genes like me logo Genes that share ontologies with ADI1: view

miRNA for ADI1 Gene

miRTarBase miRNAs that target ADI1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADI1 Gene

Localization for ADI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADI1 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADI1 Gene COMPARTMENTS Subcellular localization image for ADI1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
golgi apparatus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11602742
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11602742
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADI1: view

Pathways for ADI1 Gene

genes like me logo Genes that share pathways with ADI1: view

UniProtKB/Swiss-Prot Q9BV57-MTND_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.

Gene Ontology (GO) - Biological Process for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006595 polyamine metabolic process TAS --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with ADI1: view

Compounds for ADI1 Gene

(1) HMDB Compounds for ADI1 Gene

Compound Synonyms Cas Number PubMed IDs
Nickel
  • Carbonyl nickel powder
7440-02-0

(5) Novoseek inferred chemical compound relationships for ADI1 Gene

Compound -log(P) Hits PubMed IDs
methionine 50.2 4
fe2+ 48.6 3
carboxylate 48.3 3
oxygen 14.5 1
hydrogen 7.01 2
genes like me logo Genes that share compounds with ADI1: view

Transcripts for ADI1 Gene

mRNA/cDNA for ADI1 Gene

Unigene Clusters for ADI1 Gene

Acireductone dioxygenase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3: - -
SP4:

Relevant External Links for ADI1 Gene

GeneLoc Exon Structure for
ADI1
ECgene alternative splicing isoforms for
ADI1

Expression for ADI1 Gene

mRNA expression in normal human tissues for ADI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADI1 Gene

This gene is overexpressed in Liver (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADI1 Gene

SOURCE GeneReport for Unigene cluster for ADI1 Gene Hs.502773

mRNA Expression by UniProt/SwissProt for ADI1 Gene

Q9BV57-MTND_HUMAN
Tissue specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
genes like me logo Genes that share expressions with ADI1: view

Orthologs for ADI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADI1 35
  • 99.26 (n)
  • 99.44 (a)
ADI1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADI1 35
  • 84.36 (n)
  • 84.92 (a)
ADI1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
LOC100856577 35
  • 86.81 (n)
  • 88.49 (a)
mouse
(Mus musculus)
Mammalia Adi1 35
  • 84.54 (n)
  • 84.36 (a)
Adi1 16
Adi1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADI1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADI1 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adi1 35
  • 83.99 (n)
  • 84.83 (a)
chicken
(Gallus gallus)
Aves ADI1 35
  • 73 (n)
  • 78.21 (a)
ADI1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADI1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adi1 35
  • 74.12 (n)
  • 75.98 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
adi1 35
  • 67.6 (n)
  • 68.54 (a)
adi1 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005618 35
  • 59.24 (n)
  • 52.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32068 35
  • 55.81 (n)
  • 49.44 (a)
CG32068 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42F12.4 36
  • 38 (a)
OneToMany
K07E1.1 36
  • 35 (a)
OneToMany
T01D1.4 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADI1 36
  • 43 (a)
OneToOne
ADI1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6891 35
soybean
(Glycine max)
eudicotyledons Gma.4604 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ARD1 35
  • 62.02 (n)
  • 62.79 (a)
rice
(Oryza sativa)
Liliopsida Os03g0161800 35
  • 61.85 (n)
  • 61.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5058 36
  • 51 (a)
OneToOne
Species with no ortholog for ADI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADI1 Gene

ENSEMBL:
Gene Tree for ADI1 (if available)
TreeFam:
Gene Tree for ADI1 (if available)

Paralogs for ADI1 Gene

Pseudogenes.org Pseudogenes for ADI1 Gene

genes like me logo Genes that share paralogs with ADI1: view

No data available for Paralogs for ADI1 Gene

Variants for ADI1 Gene

Sequence variations from dbSNP and Humsavar for ADI1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3349 -- 3,498,427(+) CTGAA(A/T)ATAAG utr-variant-3-prime
rs3350 -- 3,498,537(+) TTCCC(A/C)CTACC utr-variant-3-prime
rs9950 -- 3,500,916(+) CTCAC(A/G)TCGAA synonymous-codon, reference
rs1130127 -- 3,498,854(-) GCTAG(A/G)TTATC utr-variant-3-prime
rs1130165 -- 3,498,627(-) CTGCC(A/G)TGTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADI1 Gene

Variant ID Type Subtype PubMed ID
dgv4042n71 CNV Loss 21882294
esv275511 CNV Gain+Loss 21479260

Relevant External Links for ADI1 Gene

HapMap Linkage Disequilibrium report
ADI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADI1 Gene

Disorders for ADI1 Gene

Relevant External Links for ADI1

Genetic Association Database (GAD)
ADI1
Human Genome Epidemiology (HuGE) Navigator
ADI1
genes like me logo Genes that share disorders with ADI1: view

No data available for UniProtKB/Swiss-Prot for ADI1 Gene

Publications for ADI1 Gene

  1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors. (PMID: 14718544) Uekita T. … Seiki M. (J. Biol. Chem. 2004) 2 3 4 23
  2. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. (PMID: 15938715) Hirano W. … Seiki M. (Genes Cells 2005) 2 3 4
  3. Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. (PMID: 11602742) Yeh C.-T. … Liaw Y.-F. (J. Virol. 2001) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. (PMID: 17786183) Oram S.W. … Wang Z. (Neoplasia 2007) 3 23

Products for ADI1 Gene

Sources for ADI1 Gene

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