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Aliases for ADI1 Gene

Aliases for ADI1 Gene

  • Acireductone Dioxygenase 1 2 3
  • Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding Protein-1 2 3
  • Acireductone Dioxygenase (Fe(2+)-Requiring) 3 4
  • Submergence-Induced Protein-Like Factor 3 4
  • Fe-ARD 3 4
  • MTCBP1 3 4
  • ARD 3 4
  • Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 4
  • Acireductone Dioxygenase (Ni(2+)-Requiring) 3
  • MT1-MMP Cytoplasmic Tail-Binding Protein-1 3
  • Submergence Induced Protein 2 3
  • EC 1.13.11.54 4
  • HMFT1638 3
  • MTCBP-1 4
  • Ni-ARD 3
  • Sip-L 4
  • APL1 3
  • SIPL 3
  • MtnD 3

External Ids for ADI1 Gene

Previous GeneCards Identifiers for ADI1 Gene

  • GC02M003480

Summaries for ADI1 Gene

Entrez Gene Summary for ADI1 Gene

  • This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for ADI1 Gene

ADI1 (Acireductone Dioxygenase 1) is a Protein Coding gene. Diseases associated with ADI1 include hepatitis c virus. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include oxidoreductase activity and acireductone dioxygenase [iron(II)-requiring] activity.

UniProtKB/Swiss-Prot for ADI1 Gene

  • Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Gene Wiki entry for ADI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADI1 Gene

Genomics for ADI1 Gene

Regulatory Elements for ADI1 Gene

Genomic Location for ADI1 Gene

Chromosome:
2
Start:
3,497,361 bp from pter
End:
3,519,736 bp from pter
Size:
22,376 bases
Orientation:
Minus strand

Genomic View for ADI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADI1 Gene

Proteins for ADI1 Gene

  • Protein details for ADI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV57-MTND_HUMAN
    Recommended name:
    1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
    Protein Accession:
    Q9BV57
    Secondary Accessions:
    • D6W4Y3
    • Q53HW3
    • Q53QD3
    • Q57YV7
    • Q68CK2
    • Q6ZSF7
    • Q7Z512
    • Q96P85
    • Q9NV57

    Protein attributes for ADI1 Gene

    Size:
    179 amino acids
    Molecular mass:
    21498 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per monomer. Can also use other divalent metal cations.;
    Quaternary structure:
    • Monomer (By similarity). Interacts with MMP14.
    SequenceCaution:
    • Sequence=AAL25800.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96187.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADI1 Gene

    Alternative splice isoforms for ADI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADI1 Gene

Proteomics data for ADI1 Gene at MOPED

Post-translational modifications for ADI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADI1 Gene

Antibody Products

No data available for DME Specific Peptides for ADI1 Gene

Domains & Families for ADI1 Gene

Protein Domains for ADI1 Gene

Suggested Antigen Peptide Sequences for ADI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV57

UniProtKB/Swiss-Prot:

MTND_HUMAN :
  • Belongs to the acireductone dioxygenase (ARD) family.
Family:
  • Belongs to the acireductone dioxygenase (ARD) family.
genes like me logo Genes that share domains with ADI1: view

No data available for Gene Families for ADI1 Gene

Function for ADI1 Gene

Molecular function for ADI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.

Enzyme Numbers (IUBMB) for ADI1 Gene

Gene Ontology (GO) - Molecular Function for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14718544
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity TAS --
GO:0016491 oxidoreductase activity IDA 15938715
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADI1: view

Phenotypes for ADI1 Gene

GenomeRNAi human phenotypes for ADI1:
genes like me logo Genes that share phenotypes with ADI1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADI1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ADI1 Gene

Localization for ADI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADI1 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADI1 Gene COMPARTMENTS Subcellular localization image for ADI1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
golgi apparatus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11602742
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11602742
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADI1: view

Pathways & Interactions for ADI1 Gene

genes like me logo Genes that share pathways with ADI1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BV57-MTND_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.

Gene Ontology (GO) - Biological Process for ADI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ADI1: view

No data available for SIGNOR curated interactions for ADI1 Gene

Drugs & Compounds for ADI1 Gene

(3) Drugs for ADI1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Formic acid Experimental Pharma 0
Carbon monoxide Pharma 99
methionine Nutra 70

(9) Additional Compounds for ADI1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
1,2-Dihydroxy-3-keto-5-methylthiopentene
  • 1,2-Dihydroxy-3-keto-5-methylthiopentane
  • 1,2-Dihydroxy-3-keto-5-methylthiopentene anion
  • 1,2-Dihydroxy-5-(methylsulfanyl)pent-1-en-3-one
  • 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
746507-19-7
2-Oxo-4-methylthiobutanoic acid
  • 2-Keto-4-methylthiobutyrate
  • 2-Keto-4-methylthiobutyric acid
  • 2-Ketomethiobutyrate
  • 2-Oxo-4-methylthiobutanoate
  • 2-Oxo-4-methylthiobutanoic acid
583-92-6
3-Methylthiopropionic acid
  • 3-(Methylsulfanyl)propanoate
  • 3-(Methylsulfanyl)propanoic acid
  • 3-(Methylthio)propionate
  • 3-(Methylthio)propionic acid
  • 3-Methylthiopropionate
646-01-5
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
67-63-0
genes like me logo Genes that share compounds with ADI1: view

Transcripts for ADI1 Gene

Unigene Clusters for ADI1 Gene

Acireductone dioxygenase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3: - -
SP4:

Relevant External Links for ADI1 Gene

GeneLoc Exon Structure for
ADI1
ECgene alternative splicing isoforms for
ADI1

Expression for ADI1 Gene

mRNA expression in normal human tissues for ADI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADI1 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for ADI1 Gene

This gene is overexpressed in Liver, secretome (11.5) and Amniocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADI1 Gene



SOURCE GeneReport for Unigene cluster for ADI1 Gene Hs.502773

mRNA Expression by UniProt/SwissProt for ADI1 Gene

Q9BV57-MTND_HUMAN
Tissue specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with ADI1: view

Protein tissue co-expression partners for ADI1 Gene

Primer Products

In Situ Assay Products

Orthologs for ADI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADI1 35
  • 84.36 (n)
  • 84.92 (a)
ADI1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856577 35
  • 86.81 (n)
  • 88.49 (a)
-- 36
  • 60 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adi1 35
  • 84.54 (n)
  • 84.36 (a)
Adi1 16
Adi1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADI1 35
  • 99.26 (n)
  • 99.44 (a)
ADI1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adi1 35
  • 83.99 (n)
  • 84.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ADI1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADI1 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADI1 35
  • 73 (n)
  • 78.21 (a)
ADI1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADI1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adi1 35
  • 74.12 (n)
  • 75.98 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
adi1 35
  • 67.6 (n)
  • 68.54 (a)
adi1 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005618 35
  • 59.24 (n)
  • 52.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32068 35
  • 55.81 (n)
  • 49.44 (a)
CG32068 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42F12.4 36
  • 38 (a)
OneToMany
K07E1.1 36
  • 35 (a)
OneToMany
T01D1.4 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADI1 36
  • 43 (a)
OneToOne
ADI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ARD1 35
  • 62.02 (n)
  • 62.79 (a)
soybean
(Glycine max)
eudicotyledons Gma.4604 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6891 35
rice
(Oryza sativa)
Liliopsida Os03g0161800 35
  • 61.85 (n)
  • 61.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5058 36
  • 51 (a)
OneToOne
Species with no ortholog for ADI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADI1 Gene

ENSEMBL:
Gene Tree for ADI1 (if available)
TreeFam:
Gene Tree for ADI1 (if available)

Paralogs for ADI1 Gene

Pseudogenes.org Pseudogenes for ADI1 Gene

genes like me logo Genes that share paralogs with ADI1: view

No data available for Paralogs for ADI1 Gene

Variants for ADI1 Gene

Sequence variations from dbSNP and Humsavar for ADI1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs560545784 -- 3,520,807(+) TGTTC(C/T)TATCC upstream-variant-2KB
rs560481189 -- 3,520,307(+) AATGC(A/C)TGCAA upstream-variant-2KB
rs560335180 -- 3,513,455(+) TTCTC(A/G)TGAAT intron-variant
rs559756396 -- 3,519,447(+) GCCGC(G/T)GGTCG missense, reference, upstream-variant-2KB
rs559672546 -- 3,514,071(+) ACTCC(A/C)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADI1 Gene

Variant ID Type Subtype PubMed ID
dgv4042n71 CNV Loss 21882294
esv275511 CNV Gain+Loss 21479260

Variation tolerance for ADI1 Gene

Residual Variation Intolerance Score: 82.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADI1 Gene

HapMap Linkage Disequilibrium report
ADI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADI1 Gene

Disorders for ADI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADI1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association
Search ADI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADI1

Genetic Association Database (GAD)
ADI1
Human Genome Epidemiology (HuGE) Navigator
ADI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADI1
genes like me logo Genes that share disorders with ADI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADI1 Gene

Publications for ADI1 Gene

  1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors. (PMID: 14718544) Uekita T. … Seiki M. (J. Biol. Chem. 2004) 2 23 67
  2. Transcriptome analysis of nitrogen-efficient rice over-expressing alanine aminotransferase. (PMID: 19508275) Beatty P.H. … Good A.G. (Plant Biotechnol. J. 2009) 23 67
  3. 293 cells over-expressing human ADI1 and CD81 are permissive for serum-derived hepatitis C virus infection. (PMID: 19626614) Cheng J.C. … Yeh C.T. (J. Med. Virol. 2009) 23 67
  4. Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L. (PMID: 18474223) Yeh C.T. … Cheng J.C. (Biochem. Biophys. Res. Commun. 2008) 23 67
  5. Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724. (PMID: 18237192) Chai S.C. … Pochapsky T.C. (Biochemistry 2008) 23 67

Products for ADI1 Gene

Sources for ADI1 Gene

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