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ADI1 Gene

protein-coding GIFtS: 54

GC02M003480

acireductone dioxygenase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APL1 ^¹, ²
ARD ^¹, ², ³
EC 1.13.-.- ^³
FLJ10913 ^¹, ²
HMFT1638 ^¹, ²
MTCBP-1 ^¹, ², ³
MTCBP1 ^², ³
SIP-L ^²
SIPL ^¹, ², ³

Descriptions
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ^²
Aci-reductone dioxygenase ^³
MT1-MMP cytoplasmic tail-binding protein-1 ^²
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 ^³
Submergence-induced protein 2 homolog ^³
acireductone dioxygenase 1 ^²
membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 ^²
submergence induced protein 2 ^²

External Ids
HGNC: 30576¹
Entrez Gene: 55256²
UniProtKB: Q9BV57³
Ensembl: ENSG00000182551⁷

Search outside databases for aliases for ADI1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADI1:

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding

enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the

nucleus, and may carry out different functions depending on its localization. A pseudogene that is

located on chromosome 20 has been defined for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Function: Has aci-reductone dioxygenase (ARD) activity and can function in the

5-methylthioadenosine (MTA) methionine salvage pathway. Down-regulates cell migration mediated by

MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line

Gene Wiki entry for ADI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADI1 gene

Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.2

ADI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M003480: (about GC identifiers)

Start:	3,480,698 bp from pter
End:	3,502,306 bp from pter
Size:	21,609 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022221.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57 (See protein sequence)

Recommended Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Size: 179 amino acids; 21498 Da

Cofactor: Binds 1 nickel ion per monomer. Can also use other divalent metal cations (By similarity)

Subunit: Interacts with MMP14

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus

Secondary accessions: Q53HW3 Q53QD3 Q57YV7 Q68CK2 Q6ZSF7 Q7Z512 Q96P85 Q9NV57

Alternative splicing: 2 isoforms: Q9BV57-1 Q9BV57-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060739.2

ENSEMBL proteins:

ENSP00000371525 ENSP00000333666

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADI1)
	Human Recombinant Proteins from Abnova (MTCBP-1)

OriGene Purified Recombinant Human Protein: ADI1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11602742 14718544
GO:0005737	cytoplasm	IDA	11602742 14718544
GO:0005886	plasma membrane	IDA	14718544

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Antibodies for ADI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADI1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADI1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MTCBP-1)
	Novus Biologicals Antibodies for ADI1

Assays for ADI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BV57

ProtoNet protein and cluster: Q9BV57

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Similarity: Belongs to the acireductone dioxygenase (ARD) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018269

Applied Biosystems Silencer® siRNAs for ADI1

Sigma-Aldrich siRNA for ADI1

Sigma-Aldrich shRNA for ADI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADI1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018269
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018269
untagged cDNA clone in CMV expression vector: NM_018269

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018269

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Function: Has aci-reductone dioxygenase (ARD) activity and can function in the

5-methylthioadenosine (MTA) methionine salvage pathway. Down-regulates cell migration mediated by

MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line

Enzyme Number (IUBMB): EC 1.13.-.-

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14718544
GO:0016151	nickel ion binding	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADI1 (Your Favorite Gene powered by Ingenuity)

Inositol Metabolism

GeneDecks ADI1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from

(S)-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6

Gene Network Central^TM Interacting Genes and Proteins Network for ADI1

5/6 Interacting proteins for ADI1 (ENSP00000333666³ Q9BV57¹) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP14	P50281¹	STRING (score=.779) EBI-992807, EBI-992788
OSTF1	Q92882¹	EBI-992807, EBI-1051152
CASR	ENSP00000353556³	STRING (score=.907)
ENOPH1	ENSP00000273920³	STRING (score=.844)
APIP	ENSP00000278359³	STRING (score=.809)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008652	amino acid biosynthetic process	IEA	--
GO:0009086	methionine biosynthetic process	IEA	--
GO:0019509	methionine salvage	IDA	15938715
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADI1
5 Novoseek chemical compound relationships for ADI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
methionine	52.76	7	17786183 (1), 18237192 (1), 17212658 (1), 14718544 (1)
carboxylate	51.46	3	17288413 (2), 17645333 (1)
fe2+	51.32	4	16989860 (3)
oxygen	18.36	3	18237192 (1)
hydrogen	11.07	2	17645333 (1), 17288413 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018269

Sigma-Aldrich siRNA for ADI1

Sigma-Aldrich shRNA for ADI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018269

REFSEQ mRNAs for ADI1 gene:

NM_018269.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018269

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018269
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018269
                                 untagged cDNA clone in CMV expression vector: NM_018269

Additional cDNA sequence:

AB073609.1 AB158319.1 AF087863.1 AF403478.1 AK001775.1 AK127473.1 AK222467.1 AK225278.1

BC001467.2 CR592882.1 CR593705.1 CR595221.1 CR595303.1 CR595663.1 CR598608.1 CR602689.1

CR603459.1 CR604038.1 CR604779.1 CR605242.1 CR607574.1 CR609057.1 CR611145.1 CR617197.1

CR624357.1 CR624573.1 CR625343.1

20 DOTS entries:

DT.446852 DT.99956085 DT.101985071 DT.92451152 DT.99988886 DT.100827485 DT.100827486 DT.100827475

DT.100827480 DT.97794559 DT.100700644 DT.100827474 DT.100827495 DT.91832014 DT.92451148 DT.92451149

DT.95256744 DT.95256759 DT.100827487 DT.75162181

24/493 AceView cDNA sequences (see all 493 ):

BM718092 R24642 AA693413 BG776692 BI545934 AA485906 AA360213 BU508179

BU621255 AA554338 AA314427 BQ639872 CA310252 AI476741 AI458820 CR624573

AI186551 CR625343 AA845713 BE855740 T34519 CB161069 BM838044 CR605242

highest scoring ESTs for ADI1:

AA425430 AB158319 AF087863 AK001775 AL528742 AL543802 AL546607 AL547323 AL547745 AL549060

Unigene Cluster for ADI1:

Acireductone dioxygenase 1

Hs.502773 [show with all ESTs]

Unigene Representative Sequence: AK127473

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADI1

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:			-										-
SP2:
SP3:											-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for ADI1

2 Ensembl transcripts including schematic representations:

ENST00000382093 ENST00000327435

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADI1

¹ / ² / ³

7 probe-sets matching ADI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57203_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA142864	0.60	1.00	0.82	1
222400_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC001467	0.80	1.00	0.91	1
217761_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018269	0.60	1.00	0.82	1
214019_at²	U133-A	2	0.36	0.88	--	--	--	--	--	--	--
222400_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217761_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214019_at²	U133Plus2	2	0.36	0.88	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTTGGAGTT

SOURCE GeneReport for Unigene cluster: Hs.502773
UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57
Tissue specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle
and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADI1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADI1¹	--	acireductone dioxygenase 1	98.88(n) 98.88(a)	743384 XM_001153347.1 XP_001153347.1
cow (Bos taurus)	ADI1¹	--	acireductone dioxygenase 1	84.36(n) 84.92(a)	615764 NM_001035468.1 NP_001030545.1
rat (Rattus norvegicus)	Adi1¹	--	acireductone dioxygenase 1	83.61(n) 84.27(a)	298934 NM_199097.1 NP_954528.1
mouse (Mus musculus)	Adi1^{1, 5}	12⁵	acireductone dioxygenase 1^{1, 5}	84.17(n)¹ 83.8(a)¹	104923¹ NM_134052.2¹ NP_598813.1¹ AK089966⁵ AK145831⁵ (see all 9)
chicken (Gallus gallus)	RCJMB04_7o8¹	--	acireductone dioxygenase 1	72.63(n) 78.21(a)	421918 NM_001031089.1 NP_001026260.1

About this table Species with no ortholog for ADI1

ENSEMBL Gene Tree for ADI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/185 NCBI SNPs in ADI1 are shown (see all 185 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3349^1,2	A,C,F,H	3481205(+)	`CTGAAA/TATAAG`	1	--	ut3¹ ese³		9		MN EU EA WA NA	806
	rs10179340^1,2	A,C,F,H	3502328(+)	`GCTTTG/ATCTTA`	1	--	ut5¹ ese³		4		EU EA WA	418
--	rs1130165^1,2	A,C,F,H	3481405(-)	`CTGCCG/ATGTAA`	1	--	ut3¹ ese³		5		MN EU EA WA	596
	rs1130127^1,2	A,C,F,H	3481632(-)	`GCTAGA/GTTATC`	1	--	ut3¹		9		MN EU EA WA NA	926
	rs1130333^1,2	C,F,H	3481042(-)	`TAACAG/AGAGTA`	1	--	ut3¹ ese³		10		NS EU EA WA MN	696
	rs1130319^1,2	C,F	3481062(-)	`ACAATA/CAAGCT`	1	--	ut3¹		1		MN	184
	rs10208494^1,2	C,F	3481716(+)	`GAGGCA/GCGTGT`	1	--	ut3¹ ese³		1		MN	184
--	rs6751350^1,2	C,F	3502448(+)	`AGCCCC/AGACCC`	1	--	ng3¹		2		MN EA	1252
--	rs3350^1,2	C	3481315(+)	`TTCCCA/CCTACC`	1	--	ut3¹ trp³		0	--	--	--	--
--	rs10182525^1,2	C	3503233(+)	`TCCTTC/GAAGAA`	1	--	ng3¹ tfbs³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ADI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/21 PubMed articles for ADI1 gene (see all 21 ):

Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors. (PubMed id 14718544)^{1, 2, 3, 4} Uekita T.... Seiki M. (2004)
Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. (PubMed id 15938715)^{2, 3, 4} Hirano W....Seiki M. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{3, 4} Yamada S....Nakagawara A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. (PubMed id 11602742)^{3, 4} Yeh C.-T.... Liaw Y.-F. (2001)
Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. (PubMed id 17786183)^{1, 3} Oram S.W....Wang Z. (2007)
Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing. (PubMed id 17212658)^{1, 3} Gotoh I....Seiki M. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55256	HGNC: 30576	AceView: MTCBP-1	Ensembl:ENSG00000182551	euGenes: HUgn55256
ECgene: ADI1	H-InvDB: ADI1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ADI1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADI1		Antibodies for ADI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MTCBP-1)
	Antibodies (MTCBP-1)
	Search for Chimera RNAi
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	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ADI1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADI1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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ADI1 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for ADI1

Summaries
for ADI1

Genomic Location
for ADI1

Proteins
for ADI1

Protein Domains/
Families
for ADI1

Gene Function
for ADI1

Pathways & Interactions
for ADI1

Drugs & Compounds
for ADI1

Transcripts
for ADI1

Expression
for ADI1

Orthologs
for ADI1

Paralogs
for ADI1

SNPs/Variants
for ADI1

Disorders & Mutations
for ADI1

Medical News
for ADI1

Publications
for ADI1

Search for ADI1

Genome Databases showing ADI1

Other Databases showing ADI1

Specialized Databases showing ADI1

Licensable Technologies
for ADI1

Services
for ADI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADI1 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor ADI1

Summariesfor ADI1

Genomic Locationfor ADI1

Proteinsfor ADI1

Protein Domains/Familiesfor ADI1

Gene Functionfor ADI1

Pathways & Interactionsfor ADI1

Drugs & Compoundsfor ADI1

Transcriptsfor ADI1

Expression for ADI1

Orthologsfor ADI1

Paralogsfor ADI1

SNPs/Variantsfor ADI1

Disorders & Mutationsfor ADI1

Medical Newsfor ADI1

Publicationsfor ADI1

Search for ADI1

Genome Databases showing ADI1

Other Databases showing ADI1

Specialized Databases showing ADI1

Licensable Technologiesfor ADI1

Servicesfor ADI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADI1

Summaries
for ADI1

Genomic Location
for ADI1

Proteins
for ADI1

Protein Domains/
Families
for ADI1

Gene Function
for ADI1

Pathways & Interactions
for ADI1

Drugs & Compounds
for ADI1

Transcripts
for ADI1

Expression
for ADI1

Orthologs
for ADI1

Paralogs
for ADI1

SNPs/Variants
for ADI1

Disorders & Mutations
for ADI1

Medical News
for ADI1

Publications
for ADI1

Licensable Technologies
for ADI1

Services
for ADI1