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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADI1 Gene

protein-coding GIFtS: 54
GCID: GC02M003501

acireductone dioxygenase 1

Explore 13 diseases affiliated with
ADI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acireductone Dioxygenase 1¹ ²		HMFT1638¹
ARD¹ ² ³		1,2-Dihydroxy-3-Keto-5-Methylthiopentene Dioxygenase²
SIPL¹ ² ⁵		Ni-ARD²
APL1¹ ²		Acireductone Dioxygenase (Ni(2+)-Requiring)²
MTCBP-1¹ ³		Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding Protein-1²
Acireductone Dioxygenase (Fe(2+)-Requiring)² ³		MT1-MMP Cytoplasmic Tail-Binding Protein-1²
Submergence-Induced Protein-Like Factor² ³		Submergence Induced Protein 2²
Fe-ARD² ³		EC 1.13.11.54³
MTCBP1² ³		Sip-L³
FLJ10913¹		Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1³

External Ids:	HGNC: 30576¹	Entrez Gene: 55256²	Ensembl: ENSG00000182551⁷	OMIM: 613400⁵	UniProtKB: Q9BV57³

Export aliases for ADI1 gene to outside databases

Previous GC identifer: GC02M003480

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADI1:

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are

involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different

functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. (provided by

RefSeq, May 2010)

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from

1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary

for hepatitis C virus replication in an otherwise non-permissive cell line

Gene Wiki entry for ADI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022221.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADI1 gene promoter:
USF1 C/EBPbeta USF2 USF-1:USF-2 POU6F1 (c2) Cdc5 POU2F1 POU2F1a USF-1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADI1 promoter sequence

Search SABiosciences Chromatin IP Primers for ADI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.2

ADI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADI1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M003501: view genomic region (about GC identifiers)

Start:	3,501,690 bp from pter	End:	3,523,507 bp from pter
Size:	21,818 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57 (See protein sequence)

Recommended Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Size: 179 amino acids; 21498 Da

Cofactor: Binds 1 iron ion per monomer. Can also use other divalent metal cations (By similarity)

Subunit: Monomer (By similarity). Interacts with MMP14

Subcellular location: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes

to the plasma membrane when complexed to MMP14

Sequence caution: Sequence=AAL25800.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAD38646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD96187.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: D6W4Y3 Q53HW3 Q53QD3 Q57YV7 Q68CK2 Q6ZSF7 Q7Z512 Q96P85 Q9NV57

Alternative splicing: 2 isoforms: Q9BV57-1 Q9BV57-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADI1: NX_Q9BV57

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BV57

ADI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060739.2

ENSEMBL proteins:

ENSP00000333666 ENSP00000371525 ENSP00000410178

Reactome Protein details: Q9BV57
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADI1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	11602742
GO:0005794	Golgi apparatus	IDA	--
GO:0005829	cytosol	TAS	--

ADI1 for ontologies About GeneDecksing

ADI1 Antibody Products:

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	Uscn ELISAs and CLIAs for ADI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADI1 for domains About GeneDecksing

3 InterPro domains/families:

IPR004313 Acireductn_dOase_family

IPR011051 RmlC_Cupin

IPR014710 RmlC-like_jellyroll

Graphical View of Domain Structure for InterPro Entry Q9BV57

ProtoNet protein and cluster: Q9BV57

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Similarity: Belongs to the acireductone dioxygenase (ARD) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from

1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary

for hepatitis C virus replication in an otherwise non-permissive cell line

Catalytic activity: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate

Enzyme Number (IUBMB): EC 1.13.11.54¹

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		hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: ADI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADI1 (see all 7) OriGene shRNA RFP: ADI1 OriGene siRNA: ADI1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADI1

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		GenScript: all cDNA clones in your preferred vector: ADI1 (NM_013358)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADI1
		Search LifeMap BioReagents cell lines for ADI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADI1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14718544
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	TAS	--
GO:0016491	oxidoreductase activity	IDA	15938715
GO:0046872	metal ion binding	IEA	--

ADI1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Methionine salvage pathway

	Methionine salvage pathway	1.00			Metabolism of polyamines	0.40
	S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation	0.67

Sulfur amino acid metabolism

Sulfur amino acid metabolism

1.00

Cysteine and methionine metabolism

0.36

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

methylthiopropionate biosynthesis

methylthiopropionate biosynthesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ADI1

	S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
	methylthiopropionate biosynthesis

5 Reactome Pathways for ADI1

	Metabolism of polyamines
	Metabolism
	Methionine salvage pathway
	Sulfur amino acid metabolism
	Metabolism of amino acids and derivatives

2 Kegg Pathways (Kegg details for ADI1):

	Cysteine and methionine metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from

S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6

ADI1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/20 Interacting proteins for ADI1 (Q9BV57^{1, 3} ENSP00000333666⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP14	P50281¹^,³, ENSP00000308208⁴	EBI-992807,EBI-992788 I2D: score=2 STRING: ENSP00000308208
DBT	P11182³, ENSP00000359151⁴	I2D: score=2 STRING: ENSP00000359151
ENOPH1	Q9UHY7³, ENSP00000273920⁴	I2D: score=1 STRING: ENSP00000273920
OSTF1	Q92882³, ENSP00000340836⁴	I2D: score=2 STRING: ENSP00000340836
RBKS	Q9H477³, ENSP00000306817⁴	I2D: score=1 STRING: ENSP00000306817

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000096	sulfur amino acid metabolic process	TAS	--
GO:0006595	polyamine metabolic process	TAS	--
GO:0019509	L-methionine salvage from methylthioadenosine	TAS	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

ADI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADI1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADI1

1 HMDB Compound for ADI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Nickel	Carbonyl nickel powder (see all 19)	7440-02-0	--

5 Novoseek chemical compound relationships for ADI1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methionine	50.2	7	17786183 (1), 18237192 (1), 17212658 (1), 14718544 (1)
fe2+	48.6	4	16989860 (3)
carboxylate	48.3	3	17288413 (2), 17645333 (1)
oxygen	14.5	3	18237192 (1)
hydrogen	7.01	2	17645333 (1), 17288413 (1)

Search CenterWatch for drugs/clinical trials and news about ADI1 / MTND

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADI1 gene:

NM_018269.3

Unigene Cluster for ADI1:

Acireductone dioxygenase 1

Hs.502773 [show with all ESTs]

Unigene Representative Sequence: AK127473

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000327435(uc002qxp.4) ENST00000382093(uc010yiq.2) ENST00000415131

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		hsa-miR-3910 hsa-miR-124 hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: ADI1 3' UTR sequence

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Additional cDNA sequence:

AB073609.1 AB158319.1 AF087863.1 AF403478.1 AK001775.1 AK127473.1 AK222467.1 AK225278.1

BC001467.2

21 DOTS entries:

DT.446852 DT.99956085 DT.101985071 DT.92451152 DT.99988886 DT.100827485 DT.100827486 DT.100827475

DT.100827480 DT.97794559 DT.100700644 DT.100827474 DT.100827495 DT.120990091 DT.91832014 DT.92451148

DT.92451149 DT.95256744 DT.95256759 DT.100827487 DT.75162181

24/493 AceView cDNA sequences (see all 493):

CR593705 BF732945 CK819995 BQ225593 AI458820 BM978220 BM838044 BI545934

AI300683 AI476741 CR604779 AA725579 CR607574 CR592882 T35686 BQ005756

AA314427 AV653144 BC001467 AW075588 AA586973 BU621255 BM680542 BM998596

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADI1 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:			-										-
SP2:
SP3:											-		-
SP4:

ECgene alternative splicing isoforms for ADI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTGGAGTT

About this image

ADI1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADI1

SOURCE GeneReport for Unigene cluster: Hs.502773

UniProtKB/Swiss-Prot: MTND_HUMAN, Q9BV57

Tissue specificity: Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney

SABiosciences Expression via Pathway-Focused PCR Array including ADI1:

Amino Acid Metabolism I in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADI1 gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adi1^{1 , 5}	acireductone dioxygenase 1^{1, 5}	84.54(n)¹ 84.36(a)¹		12 (11.05 cM)⁵ 104923¹ NM_134052.2¹ NP_598813.1¹ 28675231⁵
chicken (Gallus gallus)	Aves	ADI1¹	acireductone dioxygenase 1	73(n) 78.21(a)		421918 NM_001031089.1 NP_001026260.1
lizard (Anolis carolinensis)	Reptilia	ADI1⁶	--	79(a)	1 ↔ 1	1(162371455-162381334)
zebrafish (Danio rerio)	Actinopterygii	BC059549.1²	--	74.53(n)		324079 BC059549.1
fruit fly (Drosophila melanogaster)	Insecta	CG32068¹	CG32068	56.07(n) 50.87(a)		326189 NM_001104107.1 NP_001097577.1
worm (Caenorhabditis elegans)	Secernentea	F42F12.4⁶ K07E1.1⁶ (see all 3)	Protein F42F12.4 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygena... (see all 3)	40(a) 34(a) (see all 3)	possible ortholog many → 1 (see all 3)	X(12351910-12352909) II(4550891-4552172)
thale cress (Arabidopsis thaliana)	eudicotyledons	ARD1¹	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase more	62.02(n) 62.79(a)		827124 NM_117556.3 NP_567443.1
rice (Oryza sativa)	Liliopsida	NM_187765.1²	--	77.04(n)		NM_187765.1

ENSEMBL Gene Tree for ADI1 (if available)
TreeFam Gene Tree for ADI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADI1 gene

ADI1 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for ADI1
PGOHUM00000239760 PGOHUM00000244745 PGOHUM00000247657 PGOHUM00000249466

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193284126^1,2		--	3501255(+)	`CTATTA/GTATGC`	1	--	ds500¹		0	--	--	--	--
rs150583308^1,2		--	3501301(+)	`GTCTCA/GCTCTG`	1	--	ds500¹		0	--	--	--	--
rs4398301^1,2	C,	--	3501356(+)	`GCCTCG/AACCTC`	1	--	ds500¹		5		NA WA EA	362
rs139481397^1,2		--	3501514(+)	`GAGTCC/TGCAGG`	1	--	ds500¹		0	--	--	--	--
rs182526371^1,2		--	3501531(+)	`GCCCCA/GCACGA`	1	--	ds500¹		0	--	--	--	--
rs188042121^1,2		--	3501535(+)	`CGCACA/GAGGAG`	1	--	ds500¹		0	--	--	--	--
rs35674295^1,2	C,F,	--	3501567(+)	`ACAGGG/AAAAAG`	1	--	ds500¹		7		NA CSA WA EA	366
rs144192849^1,2		--	3501602(+)	`TAAAGA/CGATAG`	1	--	ds500¹		0	--	--	--	--
rs73910575^1,2	C,	--	3501614(+)	`TTATCA/GTATGA`	1	--	ds500¹		4		WA NA EA	360
rs147339757^1,2		--	3501620(+)	`TATGAA/GTGTTT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADI1 (3501690 - 3523507 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADI1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ADI1 for disorders           About GeneDecksing

OMIM gene information: 613400    OMIM disorders: --

13 diseases for ADI1:    About MalaCards

atopic dermatitis refsum disease intrahepatic cholangiocarcinoma klebsiella

dermatitis hepatitis c cholangiocarcinoma hepatoblastoma

influenza prostate cancer hepatitis pneumonia

prostatitis

Human Genome Epidemiology (HuGE) Navigator: ADI1 (1 document)

Export disorders for ADI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADI1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with ADI1)

Utopia: connect your pdf to the dynamic
world of online information

Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down- regulated in tumors. (PubMed id 14718544)^{1, 2, 3, 9} Uekita T.... Seiki M. (2004)
Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. (PubMed id 15938715)^{1, 2, 3} Hirano W.... Seiki M. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{1, 2} Yamada S....Nakagawara A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. (PubMed id 11602742)^{1, 2} Yeh C.-T.... Liaw Y.-F. (2001)
Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. (PubMed id 17786183)^{1, 9} Oram S.W....Wang Z. (2007)
293 cells over-expressing human ADI1 and CD81 are per missive for serum-derived hepatitis C virus infection. (PubMed id 19626614)^{1, 9} Cheng J.C....Yeh C.T. (2009)
Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing. (PubMed id 17212658)^{1, 9} Gotoh I....Seiki M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55256	HGNC: 30576	AceView: MTCBP-1	Ensembl:ENSG00000182551	euGenes: HUgn55256
ECgene: ADI1	Kegg: 55256	H-InvDB: ADI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADI1 gene:
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GeneCards and IP:
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ADI1 Gene

acireductone dioxygenase 1

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ADI1 (Gene Symbol)
Acireductone Dioxygenase 1
ARD
SIPL
APL1
MTCBP-1
Acireductone Dioxygenase (Fe(2+)-Requiring)
Submergence-Induced Protein-Like Factor
Fe-ARD
MTCBP1
FLJ10913
HMFT1638
1,2-Dihydroxy-3-Keto-5-Methylthiopentene Dioxygenase
Ni-ARD
Acireductone Dioxygenase (Ni(2+)-Requiring)
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail Binding Protein-1
MT1-MMP Cytoplasmic Tail-Binding Protein-1
Submergence Induced Protein 2
EC 1.13.11.54
Sip-L
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1

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ADI1 Gene

acireductone dioxygenase 1

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