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Aliases for ADH7 Gene

Aliases for ADH7 Gene

  • Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide 2 3
  • Alcohol Dehydrogenase Class IV Mu/Sigma Chain 3 4
  • Gastric Alcohol Dehydrogenase 3 4
  • Retinol Dehydrogenase 3 4
  • EC 1.1.1.1 4 63
  • Alcohol Dehydrogenase Class 4 Mu/Sigma Chain 3
  • Class IV Sigmasigma Alcohol Dehydrogenase 3
  • Class IV Sigma-1 Alcohol Dehydrogenase 3
  • Alcohol Dehydrogenase VII 3
  • Alcohol Dehydrogenase-7 3
  • EC 1.1.1 63
  • ADH4 3

External Ids for ADH7 Gene

Previous GeneCards Identifiers for ADH7 Gene

  • GC04M100580
  • GC04M100387
  • GC04M100455
  • GC04M100460
  • GC04M100690
  • GC04M096071
  • GC04M100333

Summaries for ADH7 Gene

Entrez Gene Summary for ADH7 Gene

  • This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for ADH7 Gene

ADH7 (Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide) is a Protein Coding gene. Diseases associated with ADH7 include atrophic gastritis and gastritis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include retinol dehydrogenase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH6.

UniProtKB/Swiss-Prot for ADH7 Gene

  • Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

Tocris Summary for ADH7 Gene

  • Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A, B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of ethanol to acetaldehyde.

Gene Wiki entry for ADH7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH7 Gene

Genomics for ADH7 Gene

Regulatory Elements for ADH7 Gene

Genomic Location for ADH7 Gene

Start:
99,412,261 bp from pter
End:
99,435,737 bp from pter
Size:
23,477 bases
Orientation:
Minus strand

Genomic View for ADH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH7 Gene

Proteins for ADH7 Gene

  • Protein details for ADH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40394-ADH7_HUMAN
    Recommended name:
    Alcohol dehydrogenase class 4 mu/sigma chain
    Protein Accession:
    P40394
    Secondary Accessions:
    • A2RRB6
    • A8MVN9
    • B2R760
    • B4DWV6
    • Q13713

    Protein attributes for ADH7 Gene

    Size:
    386 amino acids
    Molecular mass:
    41481 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
    SequenceCaution:
    • Sequence=AAA19002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC51351.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53961.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADH7 Gene

    Alternative splice isoforms for ADH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH7 Gene

Proteomics data for ADH7 Gene at MOPED

Post-translational modifications for ADH7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH7 Gene

Domains for ADH7 Gene

Gene Families for ADH7 Gene

HGNC:
  • ADH :Alcohol dehydrogenases

Suggested Antigen Peptide Sequences for ADH7 Gene

Graphical View of Domain Structure for InterPro Entry

P40394

UniProtKB/Swiss-Prot:

ADH7_HUMAN :
  • P40394
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
genes like me logo Genes that share domains with ADH7: view

Function for ADH7 Gene

Molecular function for ADH7 Gene

GENATLAS Biochemistry: alcohol dehydrogenase (class IV) sigma polypeptide,expressed in stomach
UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH
UniProtKB/Swiss-Prot Function: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

Enzyme Numbers (IUBMB) for ADH7 Gene

Gene Ontology (GO) - Molecular Function for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity TAS 8074657
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA 7876099
GO:0004031 aldehyde oxidase activity IDA 9600267
GO:0004745 retinol dehydrogenase activity IDA 11997393
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADH7: view
genes like me logo Genes that share phenotypes with ADH7: view

Animal Models for ADH7 Gene

MGI Knock Outs for ADH7:

Animal Model Products

CRISPR Products

miRNA for ADH7 Gene

miRTarBase miRNAs that target ADH7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADH7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ADH7 Gene

Localization for ADH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH7 Gene COMPARTMENTS Subcellular localization image for ADH7 gene
Compartment Confidence
cytosol 4
extracellular 4
nucleus 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 9600267
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADH7: view

Pathways for ADH7 Gene

genes like me logo Genes that share pathways with ADH7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ADH7 Gene

Gene Ontology (GO) - Biological Process for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IDA 9600267
GO:0006068 ethanol catabolic process IEA --
GO:0006069 ethanol oxidation TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0009617 response to bacterium IDA 11410738
genes like me logo Genes that share ontologies with ADH7: view

Compounds for ADH7 Gene

(1) Tocris Compounds for ADH7 Gene

Compound Action Cas Number
JK 184 Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway [315703-52-7]

(17) HMDB Compounds for ADH7 Gene

Compound Synonyms Cas Number PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
28822-73-3
3a,7a-Dihydroxy-5b-cholestan-26-al
  • 3a,7a-Dihydroxy-5b-cholestan-26-al
Not Available
9-cis-Retinal
  • 9-cis-Retinal
514-85-2
Acetaldehyde
  • acetaldehyde
75-07-0

(3) Drugbank Compounds for ADH7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
NADH
  • beta-DPNH
606-68-8 enzyme substrate
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(11) Novoseek inferred chemical compound relationships for ADH7 Gene

Compound -log(P) Hits PubMed IDs
ethanol 73.7 39
11-cis-retinol 73 2
cimetidine 67.2 7
acetaldehyde 64.6 1
vitamin a 63.6 10

(1) PharmGKB related drug/compound annotations for ADH7 Gene

Drug/compound Annotation
anthracyclines and related substances CA
genes like me logo Genes that share compounds with ADH7: view

Transcripts for ADH7 Gene

Unigene Clusters for ADH7 Gene

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADH7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADH7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH7 Gene

No ASD Table

Relevant External Links for ADH7 Gene

GeneLoc Exon Structure for
ADH7
ECgene alternative splicing isoforms for
ADH7

Expression for ADH7 Gene

mRNA expression in normal human tissues for ADH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH7 Gene

This gene is overexpressed in Esophagus - Mucosa (44.6) and Minor Salivary Gland (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADH7 Gene

SOURCE GeneReport for Unigene cluster for ADH7 Gene Hs.389

mRNA Expression by UniProt/SwissProt for ADH7 Gene

P40394-ADH7_HUMAN
Tissue specificity: Preferentially expressed in stomach
genes like me logo Genes that share expressions with ADH7: view

In Situ Assay Products

Orthologs for ADH7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH7 35
  • 99.4 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia ADH7 35
  • 84.7 (n)
  • 79.18 (a)
ADH7 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Adh7 35
  • 85.74 (n)
  • 89.04 (a)
Adh7 16
Adh7 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ADH7 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adh7 35
  • 84.58 (n)
  • 87.17 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15510 35
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 51 (a)
ManyToMany
adh8b 36
  • 49 (a)
ManyToMany
zgc:63568 36
  • 51 (a)
ManyToMany
zgc:77938 36
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 49 (a)
ManyToMany
Y50D4C.2 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADH2 38
SFA1 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 52 (a)
OneToMany
Species with no ortholog for ADH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH7 Gene

ENSEMBL:
Gene Tree for ADH7 (if available)
TreeFam:
Gene Tree for ADH7 (if available)

Paralogs for ADH7 Gene

Paralogs for ADH7 Gene

Selected SIMAP similar genes for ADH7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADH7: view

Variants for ADH7 Gene

Sequence variations from dbSNP and Humsavar for ADH7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs284779 -- 99,417,104(-) ggaga(C/G)catgg intron-variant
rs284784 -- 99,414,717(-) ACCAA(G/T)GTTGT intron-variant
rs284785 -- 99,414,429(-) CACTC(A/G)TTGGG intron-variant
rs284786 -- 99,412,820(-) ATATA(A/T)CTCAA utr-variant-3-prime
rs284787 -- 99,412,399(-) AGTCC(C/T)TAAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADH7 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
nsv879659 CNV Gain 21882294
nsv879660 CNV Loss 21882294
nsv517344 CNV Gain 19592680

Relevant External Links for ADH7 Gene

HapMap Linkage Disequilibrium report
ADH7
Human Gene Mutation Database (HGMD)
ADH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH7 Gene

Disorders for ADH7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for ADH7 Gene including...

Search for ADH7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADH7 Gene

(3) Novoseek inferred disease relationships for ADH7 Gene

Disease -log(P) Hits PubMed IDs
alcoholism 53.9 10
gastritis atrophic 49.3 1
gastritis 29.9 2

Relevant External Links for ADH7

Genetic Association Database (GAD)
ADH7
Human Genome Epidemiology (HuGE) Navigator
ADH7
genes like me logo Genes that share disorders with ADH7: view

No data available for UniProtKB/Swiss-Prot for ADH7 Gene

Publications for ADH7 Gene

  1. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. (PMID: 8195208) Satre M.A. … Duester G. (J. Biol. Chem. 1994) 2 3 4 23
  2. Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. (PMID: 1592118) Pares X. … Joernvall H. (FEBS Lett. 1992) 3 4 23
  3. Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. (PMID: 7925371) Farres J. … Pares X. (Eur. J. Biochem. 1994) 3 4 23
  4. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X. … Gelernter J. (Am. J. Hum. Genet. 2006) 3 23 48
  5. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. (PMID: 17918242) Luo X. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 48

Products for ADH7 Gene

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