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ADH7 Gene

protein-coding   GIFtS: 67
GCID: GC04M100333

Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide

  See ADH7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide1 2     Alcohol Dehydrogenase Class 4 Mu/Sigma Chain2
Alcohol Dehydrogenase Class IV Mu/Sigma Chain2 3     Alcohol Dehydrogenase VII2
Gastric Alcohol Dehydrogenase2 3     Alcohol Dehydrogenase-72
Retinol Dehydrogenase2 3     Class IV Sigma-1 Alcohol Dehydrogenase2
EC 1.1.1.13 8     Class IV Sigmasigma Alcohol Dehydrogenase2
ADH42     EC 1.1.18

External Ids:    HGNC: 2561   Entrez Gene: 1312   Ensembl: ENSG000001963447   OMIM: 6000865   UniProtKB: P403943   

Export aliases for ADH7 gene to outside databases

Previous GC identifers: GC04M100580 GC04M100387 GC04M100455 GC04M100460 GC04M100690 GC04M096071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADH7 Gene:
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol
dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol,
other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is
inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in
the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is
much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for ADH7 Gene:
ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide) is a protein-coding gene. Diseases associated with ADH7 include atrophic gastritis, and gastritis. GO annotations related to this gene include retinol dehydrogenase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1C.

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394
Function: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular
differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates.
Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a
role in the ethanol oxidation and contributes to the first pass ethanol metabolism

summary for ADH7 Gene:
Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into
aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and
hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least
seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A,
B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of
ethanol to acetaldehyde.

Gene Wiki entry for ADH7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH7 gene promoter:
         c-Fos   AP-1   MEF-2   Cdc5   RORalpha1   MEF-2A   c-Rel   aMEF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADH7 promoter sequence
   Search Chromatin IP Primers for ADH7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23-q24   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23-q24

ADH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100333:  view genomic region     (about GC identifiers)

Start:
100,333,418 bp from pter      End:
100,356,894 bp from pter
Size:
23,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394 (See protein sequence)
Recommended Name: Alcohol dehydrogenase class 4 mu/sigma chain  
Size: 386 amino acids; 41481 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=AAA19002.1; Type=Erroneous initiation; Sequence=AAC51351.1; Type=Erroneous initiation;
Sequence=BAG35707.1; Type=Erroneous initiation; Sequence=CAA53960.1; Type=Erroneous initiation;
Sequence=CAA53961.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ADH7:
1AGN (3D)        1D1S (3D)        1D1T (3D)    
Secondary accessions: A2RRB6 A8MVN9 B2R760 B4DWV6 Q13713
Alternative splicing: 2 isoforms:  P40394-1   P40394-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADH7: NX_P40394

Explore proteomics data for ADH7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH7 (P40394) (see all 12)
     AGASRII  RFTCKGK  CLIGCGF  EVRIKIL 


    See ADH7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000664.2  NP_001159976.1  

    ENSEMBL proteins: 
     ENSP00000414254   ENSP00000420613   ENSP00000420269   ENSP00000420300   ENSP00000209665  
    Reactome Protein details: P40394

    ADH7 Human Recombinant Protein Products:

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    Novus Biologicals ADH7 Proteins
    Novus Biologicals ADH7 Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADH7

     
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    antibodies-online proteins for ADH7 (7 products) 

     
    antibodies-online peptides for ADH7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 7):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR028635 Zinc_ADH_IV

    Graphical View of Domain Structure for InterPro Entry P40394

    ProtoNet protein and cluster: P40394

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily


    Find genes that share domains with ADH7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH7_HUMAN, P40394
    Function: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular
    differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates.
    Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a
    role in the ethanol oxidation and contributes to the first pass ethanol metabolism
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Genatlas biochemistry entry for ADH7:
    alcohol dehydrogenase (class IV) sigma polypeptide,expressed in stomach

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity TAS8074657
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA7876099
    GO:0004031aldehyde oxidase activity IDA9600267
    GO:0004745retinol dehydrogenase activity IDA11997393
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADH7           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ADH7:
     Decreased TP53 protein express  Decreased cell number and incr  Decreased number of cells in m  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adh7):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 
     taste/olfaction 

    Find genes that share phenotypes with ADH7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adh7tm1Gdu for ADH7

       genOway: Develop your customized and physiologically relevant rodent model for ADH7

    miRNA
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    miRTarBase miRNAs that target ADH7:
    hsa-mir-335-5p (MIRT018740)

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    SwitchGear 3'UTR luciferase reporter plasmidADH7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADH7_HUMAN, P40394: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    nucleus4
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA9600267
    GO:0005622intracellular ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ADH7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADH7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    4Cyclophosphamide Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.00
    5Biological oxidations
    Biological oxidations0.56


    Find genes that share SuperPaths with ADH7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ADH7
        Tyrosine metabolism p.1 (dopamine)

    1 BioSystems Pathway for ADH7
        Fatty Acid Omega Oxidation


    1 Reactome Pathway for ADH7
        Ethanol oxidation

    2 PharmGKB Pathways for ADH7
        Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH7) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Array including ADH7: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADH7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADH7 (ENSP000002096654) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process IDA9600267
    GO:0006068ethanol catabolic process IEA--
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009617response to bacterium IDA11410738

    Find genes that share ontologies with ADH7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADH7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JK 184Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway[315703-52-7]

    Selected HMDB Compounds for ADH7 (see all 17)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    2 DrugBank Compounds for ADH7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--8490052 17139284 17016423 17608724 11410692
    enzymesubstrate8490052 17139284 17016423 17608724 11410692 19583966
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ADH7 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ethanol 73.7 50 9693201 (3), 19182438 (3), 11306066 (3), 7743392 (2) (see all 32)
    11-cis-retinol 73 2 15096205 (2)
    cimetidine 67.2 10 1499876 (3), 9444664 (1), 7587772 (1), 8659686 (1) (see all 5)
    acetaldehyde 64.6 1 11306066 (1)
    vitamin a 63.6 12 8195208 (2), 15096205 (2), 11306066 (2), 19925625 (1) (see all 7)
    famotidine 60.4 4 8851452 (1), 1727201 (1)
    ranitidine 59.5 4 9444664 (1), 1727201 (1)
    retinoic acid 41.1 4 11306066 (2), 15096205 (1)
    retinoid 35.4 1 15096205 (1)
    omeprazole 22.9 1 1587193 (1)

    1 PharmGKB related drug/compound annotation for ADH7 gene    About this table
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  



    Find genes that share compounds with ADH7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADH7 gene (2 alternative transcripts): 
    NM_000673.4  NM_001166504.1  

    Unigene Cluster for ADH7:

    Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
    Hs.389  [show with all ESTs]
    Unigene Representative Sequence: NM_000673
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437033 ENST00000482593 ENST00000485660 ENST00000476959 ENST00000474027
    ENST00000209665(uc021xqj.1 uc003huv.2)
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      QuantiFast Probe-based Assays in human, mouse, rat ADH7

    Additional mRNA sequence: 

    AK223472.1 AK301657.1 AK301696.1 AK310811.1 AK312854.1 BC131512.1 L33179.1 S77168.1 
    U07821.1 U09623.1 X76342.1 

    3 DOTS entries:

    DT.409218  DT.121232319  DT.92417242 

    Selected AceView cDNA sequences (see all 31):

    CA311897 CA450373 AI863845 CD014081 L33179 X76342 S77168 BX283690 
    BU680374 U07821 CD686871 U09623 BU607509 BU686636 BV205527 CA311231 
    BV198459 BM978526 CA312156 BP342145 CB306841 CB250492 BG506480 NM_000673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADH7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAAATTC
    ADH7 Expression
    About this image


    ADH7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
     
     Adrenal Gland (Endocrine System)
    ADH7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389

    UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394
    Tissue specificity: Preferentially expressed in stomach

        Pathway & Disease-focused RT2 Profiler PCR Array including ADH7: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADH7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adh71 , 5 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide1, 5 85.74(n)1
    89.04(a)1
      3 (64.13 cM)5
    115291  NM_009626.41  NP_033756.21 
     1382177735 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    66(a)
    1 → many
    4(59594470-59604806)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    Uncharacterized protein
    (see all 7)
    70(a)
    70(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343323.1(1283546-1313061)
    GL343323.1(1339064-1349894)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.155102 Transcribed sequence with weak similarity to protein more 77.59(n)    CF377383.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:779386
    zgc:635686
    (see all 4)
    zgc:63568
    (see all 4)
    52(a)
    51(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(37121611-37132341) ENSDARG00000088366
    14(37113161-37120779) ENSDARG00000087262
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    52(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    49(a)
    32(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADH2(YMR303C)4 Glucose-repressible alcohol dehydrogenase II, catalyzes more   --   13(874337-873291) 855349  NP_014032.1 


    ENSEMBL Gene Tree for ADH7 (if available)
    TreeFam Gene Tree for ADH7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADH7 gene
    ADH1C2  ADH62  ADH42  ADH1A2  ADH1B2  ADH52  
    6 SIMAP similar genes for ADH7 using alignment to 3 protein entries:     ADH7_HUMAN (see all proteins):
    ADH1B    ADH1C    ADH1A    ADH5    ADH6    ADH4

    Find genes that share paralogs with ADH7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADH7 (see all 557)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356721091,2
    C--100138249(+) GGCAG-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs2006237671,2
    --100332919(+) TATCT-/ATCATCTA 2 -- ds50010--------
    rs339951201,2
    C--100332958(+) TATAG-/ATATATA 2 -- ds50010--------
    rs68190391,2
    C--100332959(+) ATAGAG/TATATA 2 -- ds50010--------
    rs2020600571,2
    --100332967(+) ATATA-/TGTATAC 2 -- ds50010--------
    rs1867313431,2
    --100333157(+) CTCGAA/GTTCAT 2 -- ds50010--------
    rs7291471,2
    C,F,O,A,H--100333267(+) CCCTAA/GCATTG 2 -- ds500134Minor allele frequency- G:0.21NA EA NS WA CSA 4600
    rs1918332761,2
    --100333331(+) TTTTTA/GTGTTT 2 -- ds50010--------
    rs1483730301,2
    --100333462(+) ATGTTA/TTAGAT 2 -- ut310--------
    rs2847871,2
    C,F,O,A,H--100333556(-) AGTCCC/TTAAGT 2 -- ut31 ese325Minor allele frequency- T:0.42MN NS EA NA WA CSA 4208

    HapMap Linkage Disequilibrium report for ADH7 (100333418 - 100356894 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADH7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879660CNV Loss21882294
    nsv879656CNV Gain21882294
    nsv517344CNV Gain19592680
    nsv879659CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADH7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADH7
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600086    OMIM disorders: --

    5 diseases for ADH7:    
    About MalaCards
    atrophic gastritis    gastritis    headache    alcohol dependence
    squamous cell carcinoma of the head and neck

    1 disease from the University of Copenhagen DISEASES database for ADH7:
    Alcohol dependence

    Find genes that share disorders with ADH7           About GenesLikeMe

    3 Novoseek inferred disease relationships for ADH7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 53.9 13 16237392 (5), 8244116 (2), 16385178 (2), 10208639 (1)
    gastritis atrophic 49.3 1 8819216 (1)
    gastritis 29.9 2 7766745 (1), 7978087 (1)

    Genetic Association Database (GAD): ADH7
    Human Genome Epidemiology (HuGE) Navigator: ADH7 (22 documents)

    Export disorders for ADH7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADH7 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with ADH7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. (PubMed id 8195208)1, 2, 3, 9 Satre M.A.... Duester G. (J. Biol. Chem. 1994)
    2. Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. (PubMed id 7876191)1, 2, 9 Zgombic-Knight M.... Duester G. (J. Biol. Chem. 1995)
    3. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)1, 4, 9 Luo X....Gelernter J. (Am. J. Hum. Genet. 2006)
    4. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. (PubMed id 17918242)1, 4, 9 Luo X....Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. (PubMed id 7925371)1, 2, 9 Farres J.... Pares X. (Eur. J. Biochem. 1994)
    6. Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. (PubMed id 1592118)1, 2, 9 Pares X....Joernvall H. (FEBS Lett. 1992)
    7. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PubMed id 21437268)1, 4 McKay J.D....Brennan P. (PLoS Genet. 2011)
    8. The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. (PubMed id 20700531)1, 4 Husemoen L.L....Linneberg A. (PLoS ONE 2010)
    9. A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. (PubMed id 20336794)1, 4 Wei S....Wei Q. (Cancer 2010)
    10. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131 HGNC: 256 AceView: ADH7 Ensembl:ENSG00000196344 euGenes: HUgn131
    ECgene: ADH7 Kegg: 131 H-InvDB: ADH7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADH7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADH7 gene:
    Search GeneIP for patents involving ADH7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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