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Aliases for ADH7 Gene

Aliases for ADH7 Gene

  • Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide 2 3 5
  • Alcohol Dehydrogenase Class IV Mu/Sigma Chain 3 4
  • Gastric Alcohol Dehydrogenase 3 4
  • Retinol Dehydrogenase 3 4
  • EC 1.1.1.1 4 63
  • Class IV Sigmasigma Alcohol Dehydrogenase 3
  • Class IV Sigma-1 Alcohol Dehydrogenase 3
  • Alcohol Dehydrogenase VII 3
  • Alcohol Dehydrogenase-7 3
  • EC 1.1.1 63
  • ADH4 3

External Ids for ADH7 Gene

Previous GeneCards Identifiers for ADH7 Gene

  • GC04M100580
  • GC04M100387
  • GC04M100455
  • GC04M100460
  • GC04M100690
  • GC04M096071
  • GC04M100333

Summaries for ADH7 Gene

Entrez Gene Summary for ADH7 Gene

  • This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for ADH7 Gene

ADH7 (Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide) is a Protein Coding gene. Diseases associated with ADH7 include Atrophic Gastritis and Alcohol Dependence. Among its related pathways are Phase II conjugation and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and retinol binding. An important paralog of this gene is ADH6.

UniProtKB/Swiss-Prot for ADH7 Gene

  • Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Tocris Summary for ADH7 Gene

  • Dehydrogenases are enzymes that catalyze reduction reactions through the transfer of hydrogen ions (protons) from the substrate to an acceptor or co-enzyme. Co-enzymes are small organic molecules involved in enzyme catalysis, such as nicotinamide adenine dinucleotide (NAD+ or NADH), nicotinamide adenine dinucleotide phosphate (NADP+ or NADPH), flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).

Gene Wiki entry for ADH7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH7 Gene

Genomics for ADH7 Gene

Regulatory Elements for ADH7 Gene

Enhancers for ADH7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADH7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADH7 Gene

Chromosome:
4
Start:
99,412,261 bp from pter
End:
99,435,737 bp from pter
Size:
23,477 bases
Orientation:
Minus strand

Genomic View for ADH7 Gene

Genes around ADH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH7 Gene

Proteins for ADH7 Gene

  • Protein details for ADH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40394-ADH7_HUMAN
    Recommended name:
    Alcohol dehydrogenase class 4 mu/sigma chain
    Protein Accession:
    P40394
    Secondary Accessions:
    • A2RRB6
    • A8MVN9
    • B2R760
    • B4DWV6
    • Q13713

    Protein attributes for ADH7 Gene

    Size:
    386 amino acids
    Molecular mass:
    41481 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
    SequenceCaution:
    • Sequence=AAA19002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC51351.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53960.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53961.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADH7 Gene

    Alternative splice isoforms for ADH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH7 Gene

Proteomics data for ADH7 Gene at MOPED

Post-translational modifications for ADH7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH7 Gene

Domains & Families for ADH7 Gene

Gene Families for ADH7 Gene

Suggested Antigen Peptide Sequences for ADH7 Gene

Graphical View of Domain Structure for InterPro Entry

P40394

UniProtKB/Swiss-Prot:

ADH7_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
genes like me logo Genes that share domains with ADH7: view

Function for ADH7 Gene

Molecular function for ADH7 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class IV) sigma polypeptide,expressed in stomach
UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.
UniProtKB/Swiss-Prot Function:
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Enzyme Numbers (IUBMB) for ADH7 Gene

Gene Ontology (GO) - Molecular Function for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019841 retinol binding IDA 9228021
genes like me logo Genes that share ontologies with ADH7: view
genes like me logo Genes that share phenotypes with ADH7: view

Animal Models for ADH7 Gene

MGI Knock Outs for ADH7:

Animal Model Products

miRNA for ADH7 Gene

miRTarBase miRNAs that target ADH7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH7 Gene

Localization for ADH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH7 Gene COMPARTMENTS Subcellular localization image for ADH7 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for ADH7 Gene

Pathways & Interactions for ADH7 Gene

genes like me logo Genes that share pathways with ADH7: view

Interacting Proteins for ADH7 Gene

Gene Ontology (GO) - Biological Process for ADH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IDA 9600267
GO:0006069 ethanol oxidation TAS --
GO:0010430 fatty acid omega-oxidation IDA 9600267
GO:0055114 oxidation-reduction process IEA,IDA 7876099
GO:1900116 extracellular negative regulation of signal transduction IDA 9600267
genes like me logo Genes that share ontologies with ADH7: view

No data available for SIGNOR curated interactions for ADH7 Gene

Drugs & Compounds for ADH7 Gene

(16) Drugs for ADH7 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 1924
Vitamin A Approved Nutra 438
Zinc Approved Pharma 2102
Choline Approved Nutra 139
Chloral hydrate Experimental, Illicit Pharma 14

(21) Additional Compounds for ADH7 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
  • 1-(3,4-Dihydroxyphenyl)-1,2-ethanediol
  • 3,4-Dihydroxyphenethyl glycol
  • 3,4-Dihydroxyphenylethyl glycol
  • 3,4-Dihydroxyphenylethyleneglycol
28822-73-3
3a,7a-Dihydroxy-5b-cholestan-26-al
  • 3alpha,7alpha-dihydroxy-5beta-cholestan-27-al
  • 5beta-cholestan-27-al-3alpha,7alpha-diol
  • 5beta-cholestane-3alpha,7alpha-diol-27-al

(1) Tocris Compounds for ADH7 Gene

Compound Action Cas Number
JK 184 Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway 315703-52-7

(1) ApexBio Compounds for ADH7 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
genes like me logo Genes that share compounds with ADH7: view

Drug Products

Transcripts for ADH7 Gene

Unigene Clusters for ADH7 Gene

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH7 Gene

No ASD Table

Relevant External Links for ADH7 Gene

GeneLoc Exon Structure for
ADH7
ECgene alternative splicing isoforms for
ADH7

Expression for ADH7 Gene

mRNA expression in normal human tissues for ADH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH7 Gene

This gene is overexpressed in Esophagus - Mucosa (x44.6) and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for ADH7 Gene

This gene is overexpressed in Nasal epithelium (52.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADH7 Gene



SOURCE GeneReport for Unigene cluster for ADH7 Gene Hs.389

mRNA Expression by UniProt/SwissProt for ADH7 Gene

P40394-ADH7_HUMAN
Tissue specificity: Preferentially expressed in stomach.
genes like me logo Genes that share expression patterns with ADH7: view

Primer Products

No data available for Protein tissue co-expression partners for ADH7 Gene

Orthologs for ADH7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADH7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADH7 35
  • 84.7 (n)
  • 79.18 (a)
ADH7 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adh7 35
  • 85.74 (n)
  • 89.04 (a)
Adh7 16
Adh7 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADH7 35
  • 99.4 (n)
  • 99.74 (a)
rat
(Rattus norvegicus)
Mammalia Adh7 35
  • 84.58 (n)
  • 87.17 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ADH7 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15510 35
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 51 (a)
ManyToMany
adh8b 36
  • 49 (a)
ManyToMany
zgc:63568 36
  • 51 (a)
ManyToMany
zgc:77938 36
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 49 (a)
ManyToMany
Y50D4C.2 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 44 (a)
OneToMany
ADH2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 52 (a)
OneToMany
Species with no ortholog for ADH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH7 Gene

ENSEMBL:
Gene Tree for ADH7 (if available)
TreeFam:
Gene Tree for ADH7 (if available)

Paralogs for ADH7 Gene

Paralogs for ADH7 Gene

(6) SIMAP similar genes for ADH7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADH7: view

Variants for ADH7 Gene

Sequence variations from dbSNP and Humsavar for ADH7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1573496 - 99,428,512(+) TCACT(C/G)CTTCT reference, missense
rs284779 -- 99,417,104(-) ggaga(C/G)catgg intron-variant
rs284784 -- 99,414,717(-) ACCAA(G/T)GTTGT intron-variant
rs284785 -- 99,414,429(-) CACTC(A/G)TTGGG intron-variant
rs284786 -- 99,412,820(-) ATATA(A/G/T)CTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADH7 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
nsv879659 CNV Gain 21882294
nsv879660 CNV Loss 21882294
nsv517344 CNV Gain 19592680

Variation tolerance for ADH7 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADH7 Gene

Human Gene Mutation Database (HGMD)
ADH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH7 Gene

Disorders for ADH7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADH7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atrophic gastritis
  • gastric atrophy
alcohol dependence
  • alcohol dependence, protection against
gastritis
  • acute gastric mucosal erosion
hemorrhoid
  • hemorrhoidal disease
drug dependence
  • substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search ADH7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH7

Genetic Association Database (GAD)
ADH7
Human Genome Epidemiology (HuGE) Navigator
ADH7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH7
genes like me logo Genes that share disorders with ADH7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH7 Gene

Publications for ADH7 Gene

  1. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. (PMID: 8195208) Satre M.A. … Duester G. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. (PMID: 16792560) Lee S.L. … Yin S.J. (Alcohol. Clin. Exp. Res. 2006) 23 25 26
  3. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. (PMID: 17918242) Luo X. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23
  4. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X. … Gelernter J. (Am. J. Hum. Genet. 2006) 3 23
  5. Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. (PMID: 7876191) Zgombic-Knight M. … Duester G. (J. Biol. Chem. 1995) 3 23

Products for ADH7 Gene

Sources for ADH7 Gene

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