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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADH7 Gene

protein-coding GIFtS: 66
GCID: GC04M100333

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Explore 27 diseases affiliated with
ADH7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide¹ ²		Alcohol Dehydrogenase Class 4 Mu/Sigma Chain²
Alcohol Dehydrogenase Class IV Mu/Sigma Chain² ³		Alcohol Dehydrogenase VII²
Gastric Alcohol Dehydrogenase² ³		Alcohol Dehydrogenase-7²
Retinol Dehydrogenase² ³		Class IV Sigma-1 Alcohol Dehydrogenase²
EC 1.1.1.1³ ⁸		Class IV Sigmasigma Alcohol Dehydrogenase²
ADH-4¹		EC 1.1.1⁸
ADH4²

External Ids:	HGNC: 256¹	Entrez Gene: 131²	Ensembl: ENSG00000196344⁷	OMIM: 600086⁵	UniProtKB: P40394³

Export aliases for ADH7 gene to outside databases

Previous GC identifers: GC04M100580 GC04M100387 GC04M100455 GC04M100460 GC04M100690 GC04M096071

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADH7:

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase

family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic

alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol

oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic

acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach

than liver, thus differing from the other known gene family members. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394

Function: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular

differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol

is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the

ethanol oxidation and contributes to the first pass ethanol metabolism

summary for ADH7:

Mammalian�alcohol dehydrogenases�are a family of enzymes which catalyze the oxidation of alcohols into

aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and

hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least

seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A,

B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of

ethanol to acetaldehyde.

Gene Wiki entry for ADH7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADH7 gene promoter:
c-Fos AP-1 MEF-2 Cdc5 RORalpha1 MEF-2A c-Rel aMEF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADH7 promoter sequence

Search SABiosciences Chromatin IP Primers for ADH7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23-q24 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23-q24

ADH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH7 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100333: view genomic region (about GC identifiers)

Start:	100,333,418 bp from pter	End:	100,356,894 bp from pter
Size:	23,477 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394 (See protein sequence)

Recommended Name: Alcohol dehydrogenase class 4 mu/sigma chain

Size: 386 amino acids; 41481 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Homodimer

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to

class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

Caution: It is uncertain whether Met-1 or Met-13 is the initiator

Sequence caution: Sequence=AAA19002.1; Type=Erroneous initiation; Sequence=AAC51351.1; Type=Erroneous initiation;

Sequence=BAG35707.1; Type=Erroneous initiation; Sequence=CAA53960.1; Type=Erroneous initiation; Sequence=CAA53961.1;

Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for ADH7:

1AGN (3D)

1D1S (3D)

1D1T (3D)

Secondary accessions: A2RRB6 A8MVN9 B2R760 B4DWV6 Q13713

Alternative splicing: 2 isoforms: P40394-1 P40394-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADH7: NX_P40394

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P40394

4/12 DME Specific Peptides for ADH7 (P40394) (see all 12)

AGASRII

RFTCKGK

CLIGCGF

EVRIKIL

ADH7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000664.2 NP_001159976.1

ENSEMBL proteins:

ENSP00000414254 ENSP00000420613 ENSP00000420269 ENSP00000420300 ENSP00000209665

Reactome Protein details: P40394
Human Recombinant Protein Products:

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	Uscn Proteins for ADH7

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	9600267
GO:0005622	intracellular	--	--
GO:0005625	soluble fraction	--	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

ADH7 for ontologies About GeneDecksing

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	ThermoFisher Antibody for ADH7

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	Uscn ELISAs and CLIAs for ADH7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADH7 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013149 ADH_C

IPR011032 GroES-like

IPR016040 NAD(P)-bd_dom

IPR002328 ADH_Zn_CS

IPR013154 ADH_GroES-like

Graphical View of Domain Structure for InterPro Entry P40394

ProtoNet protein and cluster: P40394

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394

Function: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular

differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol

is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the

ethanol oxidation and contributes to the first pass ethanol metabolism

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Genatlas biochemistry entry for ADH7:

alcohol dehydrogenase (class IV) sigma polypeptide,expressed in stomach

Enzyme Numbers (IUBMB): EC 1.1.1.1¹ ² EC 1.1.1²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADH7
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH7

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004022	alcohol dehydrogenase (NAD) activity	TAS	8074657
GO:0004024	alcohol dehydrogenase activity, zinc-dependent	IDA	7876099
GO:0004031	aldehyde oxidase activity	IDA	9600267
GO:0004745	retinol dehydrogenase activity	IDA	11997393

ADH7 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for ADH7:

Decreased TP53 protein express

Decreased cell number and incr

Decreased number of cells in m

Increased G1 DNA content

Animal Models:
Mouse knock-out Adh7^tm1Gdu for ADH7
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adh7):

behavior/neurological	growth/size	homeostasis/metabolism	mortality/aging	nervous system
taste/olfaction

ADH7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tyrosine metabolism

	Tyrosine metabolism	1.00			Tyrosine metabolism p.1 (dopamine)	0.28
	Tyrosine metabolism p.1 (dopamine)	0.28

Ethanol oxidation

	Ethanol oxidation	1.00			Cyclophosphamide Pathway, Pharmacodynamics	0.42
	Fatty Acid Omega Oxidation	0.47

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Biological oxidations

Biological oxidations

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADH7

Tyrosine metabolism p.1 (dopamine)

1 GeneGo (Thomson Reuters) Pathway for ADH7

Tyrosine metabolism p.1 (dopamine)

1 BioSystems Pathway for ADH7

Fatty Acid Omega Oxidation

4 Reactome Pathways for ADH7

	Ethanol oxidation
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

1 PharmGKB Pathway for ADH7

Cyclophosphamide Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for ADH7) (see all 7):

	Glycolysis / Gluconeogenesis
	Fatty acid metabolism
	Tyrosine metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450

ADH7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADH7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for ADH7 (ENSP00000209665⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1A2	ENSP00000249750⁴	STRING: ENSP00000249750
ALDH1A3	ENSP00000332256⁴	STRING: ENSP00000332256
ALDH1B1	ENSP00000366927⁴	STRING: ENSP00000366927
ALDH2	ENSP00000261733⁴	STRING: ENSP00000261733

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001523	retinoid metabolic process	IDA	9600267
GO:0006067	ethanol metabolic process	--	--
GO:0006068	ethanol catabolic process	IEA	--
GO:0006069	ethanol oxidation	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--

ADH7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADH7 for compounds About GeneDecksing

EMD Millipore small molecules for ADH7:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADH7 available from Tocris Bioscience About this table

Compound	Action	CAS #
JK 184	Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7	[315703-52-7]
Disulfiram	Aldehyde dehydrogenase inhibitor; displays a range of other activities	[97-77-8]

10/17 HMDB Compounds for ADH7 (see all 17) About this table

Compound	Synonyms	CAS #	PubMed Ids
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylglycol	(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)	28822-73-3	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
9-cis-Retinal	9-cis-Retinal (see all 5)	514-85-2	--
Acetaldehyde	acetaldehyde (see all 5)	75-07-0	--
Betaine aldehyde	(Formylmethyl)trimethylammonium (see all 8)	7418-61-3	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--
Glycerol	1,2,3-Trihydroxypropane (see all 22)	56-81-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

2 DrugBank Compounds for ADH7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	8490052 17139284 17016423 17608724 11410692
NADH	beta-DPNH (see all 18)	606-68-8	enzyme	substrate	8490052 17139284 17016423 17608724 11410692 19583966
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423

10/11 Novoseek chemical compound relationships for ADH7 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ethanol	73.7	50	9693201 (3), 19182438 (3), 11306066 (3), 7743392 (2) (see all 32)
11-cis-retinol	73	2	15096205 (2)
cimetidine	67.2	10	1499876 (3), 9444664 (1), 7587772 (1), 8659686 (1) (see all 5)
acetaldehyde	64.6	1	11306066 (1)
vitamin a	63.6	12	8195208 (2), 15096205 (2), 11306066 (2), 19925625 (1) (see all 7)
famotidine	60.4	4	8851452 (1), 1727201 (1)
ranitidine	59.5	4	9444664 (1), 1727201 (1)
retinoic acid	41.1	4	11306066 (2), 15096205 (1)
retinoid	35.4	1	15096205 (1)
omeprazole	22.9	1	1587193 (1)

Search CenterWatch for drugs/clinical trials and news about ADH7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADH7 gene (2 alternative transcripts):

NM_000673.4 NM_001166504.1

Unigene Cluster for ADH7:

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Hs.389 [show with all ESTs]

Unigene Representative Sequence: NM_000673

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000437033 ENST00000482593 ENST00000485660 ENST00000476959 ENST00000474027

ENST00000209665(uc021xqj.1 uc003huv.2)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADH7

Additional cDNA sequence:

AK223472.1 AK301657.1 AK301696.1 AK310811.1 AK312854.1 BC131512.1 L33179.1 S77168.1

U07821.1 U09623.1 X76342.1

3 DOTS entries:

DT.409218 DT.121232319 DT.92417242

24/31 AceView cDNA sequences (see all 31):

CD014081 X76342 BX283690 L33179 S77168 AI863845 CA450373 CA311897

NM_000673 CA311231 BU607509 BM979573 BP342145 CD686871 BV198459 BM978526

U07821 BG506480 CB306841 BU680374 CA312156 BU686636 U09623 BV205527

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADH7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAAAATTC

About this image

ADH7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADH7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADH7

SOURCE GeneReport for Unigene cluster: Hs.389

UniProtKB/Swiss-Prot: ADH7_HUMAN, P40394

Tissue specificity: Preferentially expressed in stomach

SABiosciences Expression via Pathway-Focused PCR Array including ADH7:

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ADH7 gene from 10/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adh7^{1 , 5}	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide^{1, 5}	85.74(n)¹ 89.04(a)¹		3 (64.13 cM)⁵ 11529¹ NM_009626.4¹ NP_033756.2¹ 138217773⁵
chicken (Gallus gallus)	Aves	F1NI80_CHICK⁶	Uncharacterized protein	69(a)	1 → many	4(61579079-61589162)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	68(a) 67(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343323.1(1237922-1251279) GL343323.1(1380739-1391213)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.15510²	Transcribed sequence with weak similarity to protein more	77.59(n)		CF377383.1
zebrafish (Danio rerio)	Actinopterygii	zgc:77938⁶ zgc:63568⁶ (see all 4)	zgc:63568 (see all 4)	53(a) 52(a) (see all 4)	many ↔ many many ↔ many (see all 4)	14(37121611-37132341) 14(37113161-37120779)
fruit fly (Drosophila melanogaster)	Insecta	Fdh⁶	Formaldehyde dehydrogenase	51(a)	1 → many	3R(6696628-6698102)
worm (Caenorhabditis elegans)	Secernentea	H24K24.3⁶ Y50D4C.2⁶	Protein Y50D4C.2	48(a) 31(a)	many ↔ many many ↔ many	V(911775-916461) V(936399-939368)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATGSNOR1⁶ AT1G32780⁶ (see all 9)	alcohol dehydrogenase-like 3 (see all 9)	47(a) 45(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(17684156-17686534) 1(11869825-11872926)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	dehydrogenase, putative, expressed (see all 9)	49(a) 46(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2(34924401-34928315) 11(5740713-5743904)
E. coli (Escherichia coli)	Gamma proteobacteria	frmA⁶ yphC⁶	alcohol dehydrogenase class III/glutathione-depend... predicted oxidoreductase, Zn-dependent and NAD(P)-...	46(a) 23(a)	many → 1 possible ortholog	Chromosome(377686-378795) Chromosome(2672722-2673783)

ENSEMBL Gene Tree for ADH7 (if available)
TreeFam Gene Tree for ADH7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADH7 gene

ADH6² ADH4² ADH1A² ADH1B² ADH5²

6 SIMAP similar genes for ADH7 using alignment to 3 protein entries: ADH7_HUMAN (see all proteins):

ADH1B ADH1C ADH1A ADH5 ADH6 ADH4

ADH7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADH7
1 CNV: 51202
Human Gene Mutation Database (HGMD): ADH7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADH7 for disorders           About GeneDecksing

OMIM gene information: 600086    OMIM disorders: --

20/27 diseases for ADH7 (see all 27):    About MalaCards

alcoholism hepatitis cluster headache atrophic gastritis

alcoholic liver cirrhosis substance dependence drug dependence liver cirrhosis

gastritis multiple system atrophy squamous cell carcinoma of the head and neck squamous cell carcinoma

coronary heart disease headache alcohol dependence anus disease

hearing loss gastric ulcer adhd gastric cancer

1 disease from the University of Copenhagen DISEASES database for ADH7:

Alcohol dependence

3 Novoseek disease relationships for ADH7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	53.9	13	16237392 (5), 8244116 (2), 16385178 (2), 10208639 (1)
gastritis atrophic	49.3	1	8819216 (1)
gastritis	29.9	2	7766745 (1), 7978087 (1)

Genetic Association Database (GAD): ADH7
Human Genome Epidemiology (HuGE) Navigator: ADH7 (22 documents)

Export disorders for ADH7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADH7 gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with ADH7)

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The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. (PubMed id 8195208)^{1, 2, 3, 9} Satre M.A.... Duester G. (1994)
Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. (PubMed id 7876191)^{1, 2, 9} Zgombic-Knight M.... Duester G. (1995)
Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. (PubMed id 7925371)^{1, 2, 9} Farres J.... Pares X. (1994)
Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. (PubMed id 1592118)^{1, 2, 9} Pares X....Joernvall H. (1992)
Identification of new single nucleotid polymorphisms (SNP) in alcohol dehydrogenase class IV ADH7 gene within a French population. (PubMed id 16180008)^{1, 4} Abbas A....Sichel F. (2006)
[Alcohol dehydrogenases ADH1B and ADH7 gene polymorphism in Russian population from the Siberian region] (PubMed id 15456134)^{1, 4} Marusin A.V....Puzyrev V.P. (2004)
Frequencies of single nucleotide polymorphism in alcohol dehydrogenase7 gene in patients with multiple system atrophy and controls. (PubMed id 14502680)^{1, 4} Kim H.S. and Lee M.S. (2003)
Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase. (PubMed id 10631979)^{1, 2} Xie P.T. and Hurley T.D. (1999)
X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity. (PubMed id 9228021)^{1, 2} Xie P.... Hurley T.D. (1997)
Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH. (PubMed id 8824810)^{1, 2} Yokoyama H.... Lieber C.S. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 131	HGNC: 256	AceView: ADH7	Ensembl:ENSG00000196344	euGenes: HUgn131
ECgene: ADH7	Kegg: 131	H-InvDB: ADH7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADH7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADH7 gene
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Patent Information for ADH7 gene:
Search GeneIP for patents involving ADH7

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alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

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ADH7 Gene

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

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