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ADH6 Gene

protein-coding   GIFtS: 63
GCID: GC04M100123

Alcohol Dehydrogenase 6 (Class V)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alcohol Dehydrogenase 6 (Class V)1 2
EC 1.1.1.13 8
ADH-52
Alcohol Dehydrogenase 62
Aldehyde Reductase2
EC 1.1.18

External Ids:    HGNC: 2551   Entrez Gene: 1302   Ensembl: ENSG000001729557   OMIM: 1037355   UniProtKB: P283323   

Export aliases for ADH6 gene to outside databases

Previous GC identifers: GC04M100373 GC04M100516 GC04M100584 GC04M100480 GC04M095861


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADH6 Gene:
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of
this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols,
hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver,
and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor
binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADH6 Gene:
ADH6 (alcohol dehydrogenase 6 (class V)) is a protein-coding gene. Diseases associated with ADH6 include fetal alcohol spectrum disorder, and partial fetal alcohol syndrome. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH6 gene promoter:
         TBP   AML1a   NRSF form 1   Lmo2   NRSF form 2   TFIID   Pax-4a   LyF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADH6 promoter sequence
   Search Chromatin IP Primers for ADH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100123:  view genomic region     (about GC identifiers)

Start:
100,123,795 bp from pter      End:
100,140,694 bp from pter
Size:
16,900 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 6  
Size: 368 amino acids; 39089 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
Secondary accessions: B3KS45 Q58F53
Alternative splicing: 2 isoforms:  P28332-1   P28332-2   

Explore the universe of human proteins at neXtProt for ADH6: NX_P28332

Explore proteomics data for ADH6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH6 (P28332) (see all 11)
     RFTCKGK  EVAPPKA  KGSVFGG  AKVTPGS 


    See ADH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000663.1  NP_001095940.1  

    ENSEMBL proteins: 
     ENSP00000378358   ENSP00000378359   ENSP00000422124   ENSP00000425275   ENSP00000237653  
     ENSP00000426187   ENSP00000384997  
    Reactome Protein details: P28332

    ADH6 Human Recombinant Protein Products:

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    Novus Biologicals ADH6 Proteins
    Novus Biologicals ADH6 Lysates
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    Cloud-Clone Corp. Proteins for ADH6

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    Cloud-Clone Corp. ELISAs for ADH6
    Cloud-Clone Corp. CLIAs for ADH6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 7):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR028633 ADH6

    Graphical View of Domain Structure for InterPro Entry P28332

    ProtoNet protein and cluster: P28332

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily


    ADH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH6_HUMAN, P28332
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity IDA1755855
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IEA--
    GO:0008270zinc ion binding NAS1593644
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    ADH6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADH6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADH6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADH6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADH6

    miRNA
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    miRTarBase miRNAs that target ADH6:
    hsa-mir-335-5p (MIRT018289)

    Block miRNA regulation of human, mouse, rat ADH6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ADH6:
    hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidADH6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADH6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ADH6 (NM_001102470)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADH6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADH6_HUMAN, P28332: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    ADH6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADH6 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Phenylalanine metabolism
    Tyrosine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    5tryptophan utilization II
    tryptophan utilization II0.71
    serotonin degradation0.00
    tryptophan utilization I0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for ADH6
        serotonin degradation
    noradrenaline and adrenaline degradation
    Fatty Acid Omega Oxidation
    tryptophan utilization II
    tryptophan utilization I

    1 Reactome Pathway for ADH6
        Ethanol oxidation

    2 PharmGKB Pathways for ADH6
        Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH6) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450


    ADH6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH6: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADH6 (ENSP000003783594) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045471response to ethanol IDA1755855
    GO:0055114oxidation-reduction process ----

    ADH6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADH6

    Selected HMDB Compounds for ADH6 (see all 23)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--

    2 DrugBank Compounds for ADH6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Abacavir-- 136470-78-5enzyme--18479171
    NADHbeta-DPNH (see all 18)606-68-8enzymesubstrate activator19583966

    1 Novoseek inferred chemical compound relationship for ADH6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ethanol 42.7 3 11306061 (1), 18621148 (1)



    ADH6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADH6 gene (2 alternative transcripts): 
    NM_000672.3  NM_001102470.1  

    Unigene Cluster for ADH6:

    Alcohol dehydrogenase 6 (class V)
    Hs.586161  [show with all ESTs]
    Unigene Representative Sequence: BC039065
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394897 ENST00000394899(uc003huo.2 uc011cef.1) ENST00000512708
    ENST00000507484 ENST00000237653(uc003hup.4 uc010ile.3) ENST00000508558
    ENST00000504257 ENST00000513262 ENST00000407820
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADH6:
    hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidADH6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ADH6

    Additional mRNA sequence: 

    AK092768.1 AK298290.1 AK316326.1 BC039065.1 

    11 DOTS entries:

    DT.445123  DT.121224110  DT.91760206  DT.100783301  DT.97821870  DT.40108785  DT.407813  DT.91760205 
    DT.91760212  DT.95229362  DT.305423 

    Selected AceView cDNA sequences (see all 72):

    BM768843 BE465731 AI650754 T58715 N94201 R01744 AA705688 N65943 
    CB159427 R88908 AK092768 N68077 BC039065 CB157429 BE465783 AA701431 
    BX098884 AJ278908 BX118467 T58782 NM_000672 AW194987 R01745 N53000 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                                        -                 -               
    SP2:                                                        -     -                           
    SP3:                                                        -     -           -               
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ADH6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADH6 expression in normal human tissues (normalized intensities)      ADH6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGCTGG
    ADH6 Expression
    About this image


    ADH6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    ADH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.586161

    UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332
    Tissue specificity: Stomach and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH6: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADH6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adh6a5 alcohol dehydrogenase 6A (class V)   --   3 (64.19 cM) 138313286 
    chicken
    (Gallus gallus)
    Aves ADH61 alcohol dehydrogenase 6 (class V) 64.71(n)
    63.73(a)
      395979  NM_205092.1  NP_990423.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    many ↔ many
    GL343323.1(1411621-1422374)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004879391 NADP-dependent alcohol dehydrogenase-like 62.47(n)
    58.18(a)
      100487939  XM_002934770.2  XP_002934816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:779386
    adh8a6
    (see all 4)
    alcohol dehydrogenase 8a
    (see all 4)
    53(a)
    52(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(37121611-37132341) ENSDARG00000088366
    13(12523132-12529475) ENSDARG00000091211
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    50(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    47(a)
    30(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFA16
    Bifunctional enzyme containing both alcohol dehydr...
    42(a)
    1 → many
    IV(159604-160764) YDL168W
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.802 Vitis vinifera alcohol dehydrogenase 1 (ADH1) mRNA, more 70.5(n)    AF194173.1 


    ENSEMBL Gene Tree for ADH6 (if available)
    TreeFam Gene Tree for ADH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADH6 gene
    ADH1C2  ADH42  ADH1A2  ADH1B2  ADH52  ADH72  
    7 SIMAP similar genes for ADH6 using alignment to 7 protein entries:     ADH6_HUMAN (see all proteins):
    ADH5    ADH1B    ADH1A    ADH7    ADH1C    ADH4
    SORD

    ADH6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADH6
    PGOHUM00000245634


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADH6 (see all 370)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831152821,2
    --95861519(+) CAGTAC/TTTGGT 1 -- ds50010--------
    rs1881439871,2
    --95861535(+) GTTTGA/TCTGTA 1 -- ds50010--------
    rs20008641,2
    C,F,O,A,H--95861609(-) TTATGT/GTGTAG 1 -- ds500140Minor allele frequency- G:0.34NA EA MN NS WA CSA 3586
    rs11309211,2
    C,F,H--95861710(-) CTTGGG/AAAATC 1 -- ut317Minor allele frequency- A:0.09MN NS EA NA 726
    rs1500039251,2
    --95861754(+) AAGGTC/TAATTT 1 -- ut310--------
    rs1929308581,2
    --95861765(+) GGGGGC/TAGAAC 1 -- ut310--------
    rs287201671,2
    C,F--95861880(-) TATTCA/TCTCTG 1 -- ut31 ese35Minor allele frequency- T:0.02NS WA 252
    rs287201661,2
    C,F--95862003(-) ATCATG/AGTTTT 1 -- ut315Minor allele frequency- A:0.02NS WA 258
    rs1843702771,2
    --95862141(+) GCAGGC/GACCCC 1 -- ut310--------
    rs1164293311,2
    C,F--95862206(+) CTGCAA/GCTAGG 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for ADH6 (100123795 - 100140694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADH6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879658CNV Loss21882294
    nsv879657CNV Loss21882294
    nsv879656CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADH6
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103735    OMIM disorders: --

    11 diseases for ADH6:    About MalaCards
    fetal alcohol spectrum disorder    partial fetal alcohol syndrome    alcohol-related birth defect    alcohol-related neurodevelopmental disorder
    fetal alcohol syndrome    alcohol dependence    drug dependence    esophageal cancer
    esophagitis    tuberculosis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for ADH6:
    Alcohol dependence     Fetal alcohol spectrum disorder

    ADH6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADH6
    Human Genome Epidemiology (HuGE) Navigator: ADH6 (8 documents)

    Export disorders for ADH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADH6 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ADH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. (PubMed id 1881901)1, 2, 3, 9 Yasunami M.... Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)1, 4, 9 Luo X....Gelernter J. (Am. J. Hum. Genet. 2006)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    5. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    6. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (PubMed id 19698717)1, 4 Cui R....Matsuda K. (Gastroenterology 2009)
    7. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (PubMed id 17185388)1, 4 Luo X....Gelernter J. (Hum. Mol. Genet. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity. (PubMed id 11095947)1, 9 Stromberg P. and Hoog J.O. (Biochem. Biophys. Res. Commun. 2000)
    10. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)1 Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130 HGNC: 255 AceView: ADH6 Ensembl:ENSG00000172955 euGenes: HUgn130
    ECgene: ADH6 Kegg: 130 H-InvDB: ADH6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADH6 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADH6 gene:
    Search GeneIP for patents involving ADH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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