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Aliases for ADH6 Gene

Aliases for ADH6 Gene

  • Alcohol Dehydrogenase 6 (Class V) 2 3
  • EC 1.1.1.1 4 63
  • Alcohol Dehydrogenase 6 3
  • Aldehyde Reductase 3
  • EC 1.1.1 63
  • ADH-5 3

External Ids for ADH6 Gene

Previous GeneCards Identifiers for ADH6 Gene

  • GC04M100373
  • GC04M100516
  • GC04M100584
  • GC04M100480
  • GC04M100123
  • GC04M095861

Summaries for ADH6 Gene

Entrez Gene Summary for ADH6 Gene

  • This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH6 Gene

ADH6 (Alcohol Dehydrogenase 6 (Class V)) is a Protein Coding gene. Diseases associated with ADH6 include fetal alcohol spectrum disorder and alcohol dependence. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH5.

Gene Wiki entry for ADH6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH6 Gene

Genomics for ADH6 Gene

Regulatory Elements for ADH6 Gene

Genomic Location for ADH6 Gene

Start:
99,202,638 bp from pter
End:
99,219,537 bp from pter
Size:
16,900 bases
Orientation:
Minus strand

Genomic View for ADH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH6 Gene

Proteins for ADH6 Gene

  • Protein details for ADH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28332-ADH6_HUMAN
    Recommended name:
    Alcohol dehydrogenase 6
    Protein Accession:
    P28332
    Secondary Accessions:
    • B3KS45
    • Q58F53

    Protein attributes for ADH6 Gene

    Size:
    368 amino acids
    Molecular mass:
    39089 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

    Alternative splice isoforms for ADH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH6 Gene

Proteomics data for ADH6 Gene at MOPED

Post-translational modifications for ADH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH6 Gene

Domains for ADH6 Gene

Gene Families for ADH6 Gene

HGNC:
  • ADH :Alcohol dehydrogenases

Suggested Antigen Peptide Sequences for ADH6 Gene

Graphical View of Domain Structure for InterPro Entry

P28332

UniProtKB/Swiss-Prot:

ADH6_HUMAN :
  • P28332
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.
genes like me logo Genes that share domains with ADH6: view

Function for ADH6 Gene

Molecular function for ADH6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB) for ADH6 Gene

Gene Ontology (GO) - Molecular Function for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 1755855
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IEA --
GO:0008270 zinc ion binding NAS 1593644
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with ADH6: view

miRNA for ADH6 Gene

miRTarBase miRNAs that target ADH6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADH6 Gene

Localization for ADH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH6 Gene COMPARTMENTS Subcellular localization image for ADH6 gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ADH6: view

Pathways for ADH6 Gene

genes like me logo Genes that share pathways with ADH6: view

Interacting Proteins for ADH6 Gene

Gene Ontology (GO) - Biological Process for ADH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0045471 response to ethanol IDA 1755855
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with ADH6: view

Compounds for ADH6 Gene

(23) HMDB Compounds for ADH6 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
28822-73-3

(2) Drugbank Compounds for ADH6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abacavir
136470-78-5 enzyme
NADH
  • beta-DPNH
606-68-8 enzyme substrate activator

(1) Novoseek inferred chemical compound relationships for ADH6 Gene

Compound -log(P) Hits PubMed IDs
ethanol 42.7 2
genes like me logo Genes that share compounds with ADH6: view

Transcripts for ADH6 Gene

Unigene Clusters for ADH6 Gene

Alcohol dehydrogenase 6 (class V):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for ADH6 Gene

GeneLoc Exon Structure for
ADH6
ECgene alternative splicing isoforms for
ADH6

Expression for ADH6 Gene

mRNA expression in normal human tissues for ADH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH6 Gene

This gene is overexpressed in Liver (41.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADH6 Gene

SOURCE GeneReport for Unigene cluster for ADH6 Gene Hs.586161

mRNA Expression by UniProt/SwissProt for ADH6 Gene

P28332-ADH6_HUMAN
Tissue specificity: Stomach and liver
genes like me logo Genes that share expressions with ADH6: view

Orthologs for ADH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH6 35
  • 99.82 (n)
  • 99.73 (a)
ADH6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADH6 35
  • 84.58 (n)
  • 78.61 (a)
ADH6 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADH6 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adh6a 16
Adh6a 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ADH6 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADH6 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adh6 35
  • 74.4 (n)
  • 66.13 (a)
chicken
(Gallus gallus)
Aves ADH6 35
  • 64.71 (n)
  • 63.73 (a)
ADH6 36
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487939 35
  • 62.47 (n)
  • 58.18 (a)
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 52 (a)
ManyToMany
adh8b 36
  • 49 (a)
ManyToMany
zgc:63568 36
  • 51 (a)
ManyToMany
zgc:77938 36
  • 53 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 47 (a)
ManyToMany
Y50D4C.2 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 42 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.80 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 51 (a)
OneToMany
Species with no ortholog for ADH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH6 Gene

ENSEMBL:
Gene Tree for ADH6 (if available)
TreeFam:
Gene Tree for ADH6 (if available)

Paralogs for ADH6 Gene

Paralogs for ADH6 Gene

Selected SIMAP similar genes for ADH6 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ADH6 Gene

genes like me logo Genes that share paralogs with ADH6: view

Variants for ADH6 Gene

Sequence variations from dbSNP and Humsavar for ADH6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_022655 -
VAR_022656 -
VAR_048198 -

Structural Variations from Database of Genomic Variants (DGV) for ADH6 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
nsv879657 CNV Loss 21882294
nsv879658 CNV Loss 21882294

Relevant External Links for ADH6 Gene

HapMap Linkage Disequilibrium report
ADH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH6 Gene

Disorders for ADH6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ADH6 Gene including...

Search for ADH6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ADH6 Gene

Relevant External Links for ADH6

Genetic Association Database (GAD)
ADH6
Human Genome Epidemiology (HuGE) Navigator
ADH6
genes like me logo Genes that share disorders with ADH6: view

No data available for UniProtKB/Swiss-Prot for ADH6 Gene

Publications for ADH6 Gene

  1. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. (PMID: 1881901) Yasunami M. … Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X. … Gelernter J. (Am. J. Hum. Genet. 2006) 3 23 48
  3. Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity. (PMID: 11095947) Stromberg P. … Hoog J.O. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (PMID: 17185388) Luo X. … Gelernter J. (Hum. Mol. Genet. 2007) 3 48

Products for ADH6 Gene

Sources for ADH6 Gene

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