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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADH6 Gene

protein-coding GIFtS: 61
GCID: GC04M100123

alcohol dehydrogenase 6 (class V)

Explore 15 diseases affiliated with
ADH6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Alcohol Dehydrogenase 6 (Class V)¹ ²
ADH-5¹ ²
EC 1.1.1.1³ ⁸
Alcohol Dehydrogenase 6²
Aldehyde Reductase²
EC 1.1.1⁸

External Ids:	HGNC: 255¹	Entrez Gene: 130²	Ensembl: ENSG00000172955⁷	OMIM: 103735⁵	UniProtKB: P28332³

Export aliases for ADH6 gene to outside databases

Previous GC identifers: GC04M100373 GC04M100516 GC04M100584 GC04M100480 GC04M095861

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADH6:

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this

family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids,

and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a

glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

Gene Wiki entry for ADH6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADH6 gene promoter:
TBP AML1a NRSF form 1 Lmo2 NRSF form 2 TFIID Pax-4a LyF-1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADH6 promoter sequence

Search SABiosciences Chromatin IP Primers for ADH6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH6 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100123: view genomic region (about GC identifiers)

Start:	100,123,795 bp from pter	End:	100,140,694 bp from pter
Size:	16,900 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332 (See protein sequence)

Recommended Name: Alcohol dehydrogenase 6

Size: 368 amino acids; 39089 Da

Cofactor: Binds 2 zinc ions per subunit (By similarity)

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to

class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

Secondary accessions: B3KS45 Q58F53

Alternative splicing: 2 isoforms: P28332-1 P28332-2

Explore the universe of human proteins at neXtProt for ADH6: NX_P28332

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28332

4/11 DME Specific Peptides for ADH6 (P28332) (see all 11)

RFTCKGK

EVAPPKA

KGSVFGG

AKVTPGS

ADH6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000663.1 NP_001095940.1

ENSEMBL proteins:

ENSP00000378358 ENSP00000378359 ENSP00000422124 ENSP00000425275 ENSP00000237653

ENSP00000426187 ENSP00000384997

Reactome Protein details: P28332
Human Recombinant Protein Products for ADH6:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ADH6
	Uscn Proteins for ADH6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005829	cytosol	TAS	--

ADH6 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ADH6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADH6 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013149 ADH_C

IPR011032 GroES-like

IPR016040 NAD(P)-bd_dom

IPR002328 ADH_Zn_CS

IPR013154 ADH_GroES-like

Graphical View of Domain Structure for InterPro Entry P28332

ProtoNet protein and cluster: P28332

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADH6_HUMAN, P28332

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB): EC 1.1.1.1¹ ² EC 1.1.1²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004022	alcohol dehydrogenase (NAD) activity	IDA	1755855
GO:0008270	zinc ion binding	NAS	1593644
GO:0009055	electron carrier activity	--	--
GO:0016491	oxidoreductase activity	--	--

ADH6 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADH6

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		hsa-miR-1252
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ethanol oxidation

	Ethanol oxidation	1.00			Cyclophosphamide Pathway, Pharmacodynamics	0.42
	Fatty Acid Omega Oxidation	0.47

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

serotonin degradation

serotonin degradation

1.00

noradrenaline and adrenaline degradation

0.40

Tyrosine metabolism

Tyrosine metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for ADH6

	serotonin degradation
	noradrenaline and adrenaline degradation
	Fatty Acid Omega Oxidation

4 Reactome Pathways for ADH6

	Ethanol oxidation
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

1 PharmGKB Pathway for ADH6

Cyclophosphamide Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for ADH6) (see all 7):

	Glycolysis / Gluconeogenesis
	Fatty acid metabolism
	Tyrosine metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450

ADH6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADH6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for ADH6 (ENSP00000378359⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1B1	ENSP00000366927⁴	STRING: ENSP00000366927
ALDH2	ENSP00000261733⁴	STRING: ENSP00000261733
ALDH3A1	ENSP00000225740⁴	STRING: ENSP00000225740
ALDH3A2	ENSP00000345774⁴	STRING: ENSP00000345774

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006069	ethanol oxidation	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0045471	response to ethanol	IDA	1755855

ADH6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADH6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADH6

10/23 HMDB Compounds for ADH6 (see all 23) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Butanol	1-Butanol (see all 10)	71-36-3	--
1-Hexanol	1-Hexyl alcohol (see all 30)	111-27-3	--
1-Pentanol	1-Pentol (see all 34)	71-41-0	--
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylglycol	(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)	28822-73-3	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
9-cis-Retinal	9-cis-Retinal (see all 5)	514-85-2	--
Acetaldehyde	acetaldehyde (see all 5)	75-07-0	--
Betaine aldehyde	(Formylmethyl)trimethylammonium (see all 8)	7418-61-3	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--

2 DrugBank Compounds for ADH6 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abacavir	--	136470-78-5	enzyme	--	18479171
NADH	beta-DPNH (see all 18)	606-68-8	enzyme	substrate activator	19583966

1 Novoseek chemical compound relationship for ADH6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ethanol	42.7	3	11306061 (1), 18621148 (1)

Search CenterWatch for drugs/clinical trials and news about ADH6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADH6 gene (2 alternative transcripts):

NM_000672.3 NM_001102470.1

Unigene Cluster for ADH6:

Alcohol dehydrogenase 6 (class V)

Hs.586161 [show with all ESTs]

Unigene Representative Sequence: BC039065

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394897 ENST00000394899(uc003huo.2 uc011cef.1) ENST00000512708

ENST00000507484 ENST00000237653(uc003hup.4 uc010ile.3) ENST00000508558

ENST00000504257 ENST00000513262 ENST00000407820

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ADH6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADH6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ADH6:
		hsa-miR-1252
		SwitchGear 3'UTR luciferase reporter plasmid: ADH6 3' UTR sequence

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Additional cDNA sequence:

AK092768.1 AK298290.1 AK316326.1 BC039065.1

11 DOTS entries:

DT.445123 DT.121224110 DT.91760206 DT.100783301 DT.97821870 DT.40108785 DT.407813 DT.91760205

DT.91760212 DT.95229362 DT.305423

24/72 AceView cDNA sequences (see all 72):

BE465731 CB159427 AI650754 R01744 N65943 N94201 T58715 AA705688

BM768843 BX495325 CB157429 CB116993 BX497498 BX106466 AW779670 R01745

AW194987 BE465783 T58782 BX118467 R88908 BX098884 N53000 AJ278908

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH6 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b
SP1:																			-						-
SP2:																			-		-
SP3:																			-		-				-
SP4:

ECgene alternative splicing isoforms for ADH6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADH6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGGCTGG

About this image

ADH6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADH6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADH6

SOURCE GeneReport for Unigene cluster: Hs.586161

UniProtKB/Swiss-Prot: ADH6_HUMAN, P28332

Tissue specificity: Stomach and liver

SABiosciences Expression via Pathway-Focused PCR Arrays including ADH6:

Drug Metabolism: Phase I Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADH6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ADH6 gene from 7/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADH6¹	alcohol dehydrogenase 6 (class V)	64.8(n) 63.9(a)		395979 NM_205092.1 NP_990423.1
zebrafish (Danio rerio)	Actinopterygii	zgc:77938⁶ adh8a⁶ (see all 4)	alcohol dehydrogenase 8a (see all 4)	52(a) 51(a) (see all 4)	many ↔ many many ↔ many (see all 4)	14(37121611-37132341) 13(12523132-12529475)
fruit fly (Drosophila melanogaster)	Insecta	Fdh⁶	Formaldehyde dehydrogenase	49(a)	1 → many	3R(6696628-6698102)
worm (Caenorhabditis elegans)	Secernentea	H24K24.3⁶ Y50D4C.2⁶	Protein Y50D4C.2	45(a) 29(a)	many ↔ many many ↔ many	V(911775-916461) V(936399-939368)
thale cress (Arabidopsis thaliana)	eudicotyledons	ADH1⁶ ATGSNOR1⁶ (see all 9)	alcohol dehydrogenase class-3 (see all 9)	47(a) 46(a) (see all 9)	many ↔ many many ↔ many (see all 9)	1(28975394-28977417) 5(17684156-17686534)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	dehydrogenase, putative, expressed (see all 9)	46(a) 46(a) (see all 9)	many ↔ many many ↔ many (see all 9)	11(5740713-5743904) 2(34924401-34928315)
E. coli (Escherichia coli)	Gamma proteobacteria	frmA⁶ yphC⁶	alcohol dehydrogenase class III/glutathione-depend... predicted oxidoreductase, Zn-dependent and NAD(P)-...	47(a) 25(a)	1 ↔ many possible ortholog	Chromosome(377686-378795) Chromosome(2672722-2673783)

ENSEMBL Gene Tree for ADH6 (if available)
TreeFam Gene Tree for ADH6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADH6 gene

ADH4² ADH1A² ADH1B² ADH5² ADH7²

7 SIMAP similar genes for ADH6 using alignment to 7 protein entries: ADH6_HUMAN (see all proteins):

ADH5 ADH1B ADH1A ADH7 ADH1C ADH4

SORD

ADH6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADH6
PGOHUM00000245634

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1130921^1,2	C,F,H	--	95861710(-)	`CTTGGG/AAAATC`	1	--	ut3¹		7	MN NS EA NA	726
rs28720167^1,2	C,F	--	95861880(-)	`TATTCA/TCTCTG`	1	--	ut3¹ ese³		5	NS WA	252
rs28720166^1,2	C,F	--	95862003(-)	`ATCATG/AGTTTT`	1	--	ut3¹		5	NS WA	258
rs116429331^1,2	C,F	--	95862206(+)	`CTGCAA/GCTAGG`	1	--	ut3¹		1	WA	118
rs28720164^1,2	C,F	--	95862920(-)	`AGATGC/TTCCCA`	1	--	ut3¹ ese³		5	NS WA	262
rs115864341^1,2	C,F	--	95863733(+)	`TATTTT/GATTAG`	2	--	int¹ ut3¹		1	WA	118
rs28720162^1,2	C	--	95863839(-)	`GTAGAAGA/-AGGGT`	2	--	int¹ ut3¹		4	NS	138
rs78873228^1,2	C,F	--	95864109(+)	`GGAAAG/AGTCAT`	2	--	int¹		1	WA	118
rs4283664^1,2	C,H	--	95864343(+)	`AGCAGT/CGAATC`	2	--	int¹		6	NS EA NA	420
rs28720160^1,2	C	--	95864565(-)	`TATATT/CGCTTT`	2	--	int¹		5	NS WA	264

HapMap Linkage Disequilibrium report for ADH6 (100123795 - 100140694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADH6: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADH6 for disorders           About GeneDecksing

OMIM gene information: 103735    OMIM disorders: --

15 diseases for ADH6:    About MalaCards

alcoholism alcohol-related birth defect alcohol-related neurodevelopmental disorder partial fetal alcohol syndrome

fetal alcohol spectrum disorder fetal alcohol syndrome birth defects drug dependence

alcohol dependence adhd esophageal cancer esophagitis

pneumonia tuberculosis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ADH6:

Alcohol dependence

Human Genome Epidemiology (HuGE) Navigator: ADH6 (8 documents)

Export disorders for ADH6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADH6 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with ADH6)

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world of online information

A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. (PubMed id 1881901)^{1, 2, 3, 9} Yasunami M.... Yoshida A. (1991)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity. (PubMed id 11095947)^{1, 9} Stromberg P. and Hoog J.O. (2000)
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)^{1, 9} Luo X....Gelernter J. (2006)
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)¹ Zhang X....Wu X. (2010)
Conformational changes and catalysis by alcohol dehyd rogenase. (PubMed id 19583966)⁷ Plapp B.V. (2010)
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)¹ Saito A....Kamatani N. (2009)
Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)¹ Tabakoff B....Hoffman P.L. (2009)
Functional variants in ADH1B and ALDH2 coupled with a lcohol and smoking synergistically enhance esophageal cancer risk. (PubMed id 19698717)¹ Cui R....Matsuda K. (2009)
A review of the pharmacokinetics of abacavir. (PubMed id 18479171)⁷ Yuen G.J....Pakes G.E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 130	HGNC: 255	AceView: ADH6	Ensembl:ENSG00000172955	euGenes: HUgn130
ECgene: ADH6	Kegg: 130	H-InvDB: ADH6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADH6	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh6/

Intellectual Property for ADH6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADH6 gene:
Search GeneIP for patents involving ADH6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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alcohol dehydrogenase 6 (class V)

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ADH6 Gene

alcohol dehydrogenase 6 (class V)

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