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Aliases for ADH5 Gene

Aliases for ADH5 Gene

  • Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
  • Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
  • S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
  • Alcohol Dehydrogenase Class Chi Chain 3 4
  • Alcohol Dehydrogenase Class-III 3 4
  • S-Nitrosoglutathione Reductase 2 3
  • Formaldehyde Dehydrogenase 2 3
  • EC 1.1.1.1 4 61
  • GSH-FDH 3 4
  • FALDH 3 4
  • ADHX 3 4
  • FDH 3 4
  • Alcohol Dehydrogenase (Class III), Chi Polypeptide 3
  • Epididymis Secretory Sperm Binding Protein Li 60p 3
  • Alcohol Dehydrogenase Class-3 3
  • Alcohol Dehydrogenase 5 4
  • EC 1.1.1.284 4
  • EC 1.1.1.- 4
  • HEL-S-60p 3
  • EC 1.1.1 61
  • ADH-3 3
  • GSNOR 3

External Ids for ADH5 Gene

Previous HGNC Symbols for ADH5 Gene

  • FDH

Previous GeneCards Identifiers for ADH5 Gene

  • GC04M100238
  • GC04M100385
  • GC04M100454
  • GC04M100459
  • GC04M100349
  • GC04M099992
  • GC04M095730

Summaries for ADH5 Gene

Entrez Gene Summary for ADH5 Gene

  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ADH5 Gene

ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Methanol Poisoning and Pharyngitis. Among its related pathways are Folate-Alcohol and Cancer Pathway and Drug metabolism - cytochrome P450. GO annotations related to this gene include protein homodimerization activity and electron carrier activity. An important paralog of this gene is ADH1A.

UniProtKB/Swiss-Prot for ADH5 Gene

  • Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Gene Wiki entry for ADH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene

Genomics for ADH5 Gene

Regulatory Elements for ADH5 Gene

Enhancers for ADH5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F098927 1.4 FANTOM5 ENCODE 12.9 +159.7 159669 4.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 LOC100507053 ADH5 ENSG00000272777 ADH1B ADH1C EIF4E RAP1GDS1 ENSG00000263923
GH04F098641 1.4 Ensembl ENCODE 12.9 +445.7 445734 3.0 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 LOC100507053 ENSG00000260641 ADH5 ADH1B ADH1C ENSG00000214559 RAP1GDS1 TSPAN5 GC04P098586
GH04F099086 1.1 ENCODE 15.4 -0.5 -481 6.5 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ELK1 ENSG00000272777 ADH5 ADH4 LOC100507053 PIR42405
GH04F099402 1.6 FANTOM5 Ensembl ENCODE 8.9 -315.7 -315662 3.6 PKNOX1 ARID4B DMAP1 YY1 CBX5 ZNF143 FOS JUNB MIER2 REST ADH4 ADH6 LOC100507053 PCNAP1 ADH5 ADH1A ADH1B ADH1C LOC102723576
GH04F099562 1.1 ENCODE 12.9 -475.2 -475226 3.4 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS SP3 MTTP LOC100507053 TRMT10A ADH5 ADH1B ADH1C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADH5 on UCSC Golden Path with GeneCards custom track

Promoters for ADH5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001246066 100 5000 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ELK1

Genomic Location for ADH5 Gene

Chromosome:
4
Start:
99,070,978 bp from pter
End:
99,088,801 bp from pter
Size:
17,824 bases
Orientation:
Minus strand

Genomic View for ADH5 Gene

Genes around ADH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH5 Gene

Proteins for ADH5 Gene

  • Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11766-ADHX_HUMAN
    Recommended name:
    Alcohol dehydrogenase class-3
    Protein Accession:
    P11766
    Secondary Accessions:
    • Q6FHR2

    Protein attributes for ADH5 Gene

    Size:
    374 amino acids
    Molecular mass:
    39724 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH5 Gene

neXtProt entry for ADH5 Gene

Selected DME Specific Peptides for ADH5 Gene

P11766:
  • EVAPPKA
  • ESVGEGVT
  • RFTCKGK
  • GVDYSFE
  • PVILGHE
  • TFSEYTV
  • AGASRII
  • GATECINP
  • WEAGKPL
  • KPIQEVL
  • EMTDGGV
  • LGHEGAGIVES
  • APLDKVC
  • DINKDKF
  • GIVESVG

Post-translational modifications for ADH5 Gene

  • Ubiquitination at Lys 101, Lys 113, Lys 228, Lys 233, Lys 323, and Lys 366
  • Modification sites at PhosphoSitePlus

Other Protein References for ADH5 Gene

Domains & Families for ADH5 Gene

Gene Families for ADH5 Gene

Graphical View of Domain Structure for InterPro Entry

P11766

UniProtKB/Swiss-Prot:

ADHX_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
genes like me logo Genes that share domains with ADH5: view

Function for ADH5 Gene

Molecular function for ADH5 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Enzyme Numbers (IUBMB) for ADH5 Gene

Gene Ontology (GO) - Molecular Function for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IEA --
GO:0005504 fatty acid binding IDA 8460164
GO:0008270 zinc ion binding IEA,IDA 6375718
GO:0009055 electron carrier activity TAS 8460164
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ADH5: view
genes like me logo Genes that share phenotypes with ADH5: view

Animal Models for ADH5 Gene

MGI Knock Outs for ADH5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADH5

miRNA for ADH5 Gene

miRTarBase miRNAs that target ADH5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene

Localization for ADH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADH5 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ADH5: view

Pathways & Interactions for ADH5 Gene

genes like me logo Genes that share pathways with ADH5: view

Gene Ontology (GO) - Biological Process for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA --
GO:0003016 respiratory system process IEA --
GO:0006069 ethanol oxidation IEA,TAS --
GO:0018119 peptidyl-cysteine S-nitrosylation IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with ADH5: view

No data available for SIGNOR curated interactions for ADH5 Gene

Drugs & Compounds for ADH5 Gene

(23) Drugs for ADH5 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 2043
Zinc Approved Pharma 2231
Vitamin A Approved, Vet_approved Nutra 468
Chloral hydrate Approved, Illicit, Vet_approved Pharma 15
Glycerol Approved, Experimental Pharma 223

(43) Additional Compounds for ADH5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(2-Naphthyl)methanol
1-Hydroxymethylnaphthalene
1-Naphthaldehyde
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8

(2) ApexBio Compounds for ADH5 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with ADH5: view

Transcripts for ADH5 Gene

Unigene Clusters for ADH5 Gene

Alcohol dehydrogenase 5 (class III), chi polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH5 Gene

No ASD Table

Relevant External Links for ADH5 Gene

GeneLoc Exon Structure for
ADH5
ECgene alternative splicing isoforms for
ADH5

Expression for ADH5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADH5 Gene



Protein tissue co-expression partners for ADH5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADH5 Gene:

ADH5

SOURCE GeneReport for Unigene cluster for ADH5 Gene:

Hs.78989
genes like me logo Genes that share expression patterns with ADH5: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADH5 Gene

Orthologs for ADH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH5 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
ADH5 34 35
  • 92.6 (n)
-- 35
  • 74 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ADH5 34 35
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Adh5 34 16 35
  • 88.59 (n)
rat
(Rattus norvegicus)
Mammalia Adh5 34
  • 88.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ADH5 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADH5 34 35
  • 79.41 (n)
lizard
(Anolis carolinensis)
Reptilia ADH5 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adh5 34
  • 76.7 (n)
zebrafish
(Danio rerio)
Actinopterygii adh5 34
  • 73.14 (n)
zgc:77938 35
  • 63 (a)
ManyToMany
zgc:63568 35
  • 62 (a)
ManyToMany
adh8a 35
  • 61 (a)
ManyToMany
adh8b 35
  • 56 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010499 34
  • 66.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36 34 35
  • 66.22 (n)
worm
(Caenorhabditis elegans)
Secernentea H24K24.3a 36
  • 69 (a)
H24K24.3b 36
  • 68 (a)
Y50D4C.2 36 35
  • 67 (a)
H24K24.3 34 35
  • 64.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 34 35 37
  • 61.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12342g 34
  • 61.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL148C 34
  • 58.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HOT5 34
  • 64.77 (n)
rice
(Oryza sativa)
Liliopsida Os02g0815500 34
  • 63.87 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2516 34
corn
(Zea mays)
Liliopsida Zm.2742 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 35
  • 71 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC13B11.04c 34
  • 61.84 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06652 34
  • 59.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14208 34
Species where no ortholog for ADH5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH5 Gene

ENSEMBL:
Gene Tree for ADH5 (if available)
TreeFam:
Gene Tree for ADH5 (if available)

Paralogs for ADH5 Gene

Paralogs for ADH5 Gene

genes like me logo Genes that share paralogs with ADH5: view

Variants for ADH5 Gene

Sequence variations from dbSNP and Humsavar for ADH5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1050636 -- 99,076,769(-) CTTTG(G/T)ATAAA reference, missense
rs1050637 -- 99,076,379(-) GATTT(A/T)AGTAA reference, missense
rs10582873 -- 99,089,443(+) TCTTT(-/CTTT)GTTTG intron-variant, upstream-variant-2KB
rs1061187 -- 99,071,702(-) CACTT(C/T)GAGAT utr-variant-3-prime
rs10616090 -- 99,090,473(+) AAATA(-/AATA)CCATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADH5 Gene

Variant ID Type Subtype PubMed ID
nsv1136894 CNV deletion 24896259
nsv1002927 CNV gain 25217958

Variation tolerance for ADH5 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADH5 Gene

Human Gene Mutation Database (HGMD)
ADH5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene

Disorders for ADH5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADH5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
methanol poisoning
pharyngitis
  • acute sore throat
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search ADH5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH5

Genetic Association Database (GAD)
ADH5
Human Genome Epidemiology (HuGE) Navigator
ADH5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH5
genes like me logo Genes that share disorders with ADH5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene

Publications for ADH5 Gene

  1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur M.W. … Edenberg H.J. (Gene 1992) 2 3 4 22 64
  2. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H. … London S.J. (J. Allergy Clin. Immunol. 2007) 3 22 46 64
  3. Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang Z.-N. … Hurley T.D. (J. Mol. Biol. 1997) 3 4 22 64
  4. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B. … Vallee B.L. (Biochemistry 1993) 3 4 22 64
  5. Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K. … Vallee B.L. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64

Products for ADH5 Gene

Sources for ADH5 Gene

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