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Aliases & Descriptions for ADH5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ADH-3 1, 2 | | ADHX 1, 2, 3 | | EC 1.1.1.1,EC 1.1.1.284,EC 1.1.1.- 3 | | FALDH 3 | | FDH 2, 3, 5 | | GSH-FDH 3 | | GSNOR 2 |
| | | Descriptions |
|---|
| Alcohol dehydrogenase 5 3 | | Alcohol dehydrogenase class chi chain 3 | | Alcohol dehydrogenase class-III 3 | | Glutathione-dependent formaldehyde dehydrogenase 2, 3 | | S-(hydroxymethyl)glutathione dehydrogenase 3 | | alcohol dehydrogenase (class III), chi polypeptide 2 | | alcohol dehydrogenase 5 (class III), chi polypeptide 2 | | alcohol dehydrogenase 5, chi polypeptide 2 | | formaldehyde dehydrogenase 1, 2 |
|
| | Search outside databases for aliases for ADH5 genePrevious GC identifers: GC04M100385 GC04M100454 GC04M100459 GC04M100349 |
Summaries for ADH5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ADH5: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathioneGene Wiki entry for ADH5 |
Genomic Location for ADH5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ADH5 gene 
Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23ADH5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M100238:
(about GC identifiers)
Start:
|
100,211,152 bp from pter |
End:
|
100,240,090 bp from pter |
Size:
|
28,939 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for ADH5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766 (See
protein sequence)Recommended Name: Alcohol dehydrogenase class-3 Size: 374 amino acids; 39724 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
PDB structures from and Proteopedia :1M6H (3D)
 1M6W (3D)
 1MA0 (3D)
 1MC5 (3D)
 1MP0 (3D)
 1TEH (3D)
 2FZE (3D)
 2FZW (3D)
 
Secondary accessions: Q6FHR2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000662.3
ENSEMBL proteins: ENSP00000296412
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ADH5: Assays for ADH5: | Protein
Domains/ Families for ADH5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11766
ProtoNet protein and cluster: P11766 2 Blocks protein families: IPB002328 Zinc-containing alcohol dehydrogenase IPB013154 Alcohol dehydrogenase GroES-like
UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | Gene Function for ADH5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000671
Applied Biosystems Silencer® siRNAs for ADH5
Sigma-Aldrich siRNA and siRNA Panels for ADH5  Sigma-Aldrich shRNA for ADH5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000671                                  untagged cDNA clones in CMV expression vector (see all 2): NM_000671 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000671
UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathioneCatalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADHCatalytic activity: S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)HEnzyme Number (IUBMB): EC 1.1.1.1,EC Genatlas biochemistry entry for ADH5:alcohol dehydrogenase (class III),chi polypeptide (see ADH@)4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adh5):
5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10
): About this table | Pathways & Interactions for ADH5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ADH5 (Your Favorite Gene powered by Ingenuity) (see all 6
) 
Gene Network CentralTM Interacting Genes and Proteins Network for ADH5 
5/42 Interacting proteins for ADH5 (P117662 ENSP000002964123) via UniProtKB, MINT, and/or STRING (see all 42
)About this table
5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001523 | retinoid metabolic process |
IEA | -- | | GO:0003016 | respiratory system process |
IEA | -- | | GO:0006069 | ethanol oxidation |
IEA | -- | | GO:0018119 | peptidyl-cysteine S-nitrosylation |
IEA | -- | | GO:0032496 | response to lipopolysaccharide |
IEA | -- | About this table
|
Drugs & Compounds for ADH5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ADH5 10/20 Novoseek chemical compound relationships for ADH5 gene (see all 20
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 8-thio-octanoate |
92.02 |
1 |
7485831 (1) |
| 12-hydroxydodecanoic acid |
91.91 |
1 |
8494891 (1) |
| 10-formyltetrahydrofolate |
87.32 |
23 |
16597835 (3), 18848533 (3), 12684508 (2), 11320079 (2) (see all 5) |
| mycothiol |
78.05 |
2 |
12209256 (1), 10609883 (1) |
| tetrahydrofolate |
71.40 |
6 |
12209256 (1), 16712799 (1), 18848533 (1), 11320079 (1) |
| nad+ |
61.08 |
4 |
9531510 (1), 11038276 (1), 17098416 (1) |
| nadh |
57.48 |
2 |
10699858 (1), 17092593 (1) |
| ethanol |
56.22 |
11 |
12782305 (3), 11054102 (1), 8612630 (1), 7598661 (1) (see all 7) |
| methylamine |
50.55 |
3 |
11038276 (2) |
| hydride |
40.92 |
1 |
15627379 (1) |
About this table
|
Transcripts for ADH5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000671
Sigma-Aldrich siRNA and siRNA Panels for ADH5  Sigma-Aldrich shRNA for ADH5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000671 REFSEQ mRNAs for ADH5 gene: NM_000671.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000671               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000671                                  untagged cDNA clones in CMV expression vector (see all 2): NM_000671  Additional cDNA sequence: AK124994.1 AK129570.1 AK226177.1 AK312367.1 BC014665.1 BC070491.1 BT019832.1 BT019833.1 CR536491.1 CR541689.1 CR590837.1 CR592134.1 CR593976.1 CR598204.1 CR603698.1 CR606065.1 CR616221.1 CR617310.1 CR619952.1 CR622943.1 CR625434.1 CR625527.1 M29872.1 M30471.1 24/25 DOTS entries (see all 25
): DT.449820 DT.97795127 DT.121224230 DT.100865484 DT.92452643 DT.100865495 DT.100865478 DT.92452641 DT.100865499 DT.121224148 DT.121224168 DT.40211879 DT.100865498 DT.100865482 DT.100031725 DT.100865486 DT.101984557 DT.100865503 DT.121224112 DT.100865500 DT.121224295 DT.92414394 DT.92452644 DT.100031720 24/570 AceView cDNA sequences (see all 570
):BG775256 BF038336 AL535009 AI127077 BQ436206 BU167762 CD721987 AW104095 BG033342 CR536491 BM849265 BE855537 CR619952 CA424815 CA310028 BE464374 CA441045 BG744349 AL538331 CB215846 BQ182013 BM836352 BE855625 CR593976
highest scoring ESTs for ADH5:AA376989 AI444624 AI929349 AU279477 BC014665 BC070491 BE019767 BE278525 BE538100 BE559997 Unigene Cluster for ADH5: Alcohol dehydrogenase 5 (class III), chi polypeptide Hs.78989 [show with all ESTs]Unigene Representative Sequence: AK226177
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000296412
|
Expression for ADH5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADH5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADH5
1 / 2 / 3 6 probe-sets matching ADH5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACCTGTTTT
SOURCE GeneReport for Unigene cluster: Hs.78989
Expression variation in blood from EXPOLDB for ADH5 |
Orthologs for ADH5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADH5 gene from 5/23 species (see all 23
)
About this table Species with no ortholog for ADH5
ENSEMBL Gene Tree for ADH5 | Paralogs for ADH5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ADH5 gene
- ADH1C2 ADH42 ADH1B2 ADH72
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for ADH5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADH5 (up to first 250kb)
|
Disorders & Mutations for ADH5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 103710
1 Novoseek disease relationship for ADH5 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
1.53 |
2 |
11471570 (1), 11073833 (1) |
About this table
Human Gene Mutation Database: ADH5 Human Genome Epidemiology Navigator: ADH5 (6 documents)
|
Medical News for ADH5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ADH5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/119 PubMed articles for ADH5 gene (see all 119
):- Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PubMed id 1446828)1, 2, 3, 4 Hur M.W. and Edenberg H.J. (1992)
- Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PubMed id 8494891)1, 3, 4 Holmquist B.... Vallee B.L. (1993)
- Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PubMed id 8460164)1, 3, 4 Engeland K....Vallee B.L. (1993)
- Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (PubMed id 9018047)1, 3, 4 Yang Z.-N.... Hurley T.D. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- cDNA sequence of human class III alcohol dehydrogenase. (PubMed id 2818582)3, 4 Sharma C.P.... Vallee B.L. (1989)
- Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. (PubMed id 2679557)3, 4 Giri P.R.... Goldman D. (1989)
- Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. (PubMed id 3365377)3, 4 Kaiser R.... Joernvall H. (1988)
- Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme. (PubMed id 6424546)2, 3 Adinolfi A....Hopkinson D.A. (1984)
- Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. (PubMed id 12484756)1, 3 Sanghani P.C....Hurley T.D. (2002)
|
Search for ADH5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ADH5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADH5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADH5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/adh5/ |
|
| | | About This Section
| --
| Services for ADH5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ADH5:

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