Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADH5 Gene

Aliases for ADH5 Gene

  • Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3 5
  • Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
  • S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
  • Alcohol Dehydrogenase Class Chi Chain 3 4
  • Alcohol Dehydrogenase Class-III 3 4
  • Formaldehyde Dehydrogenase 2 3
  • EC 1.1.1.1 4 63
  • GSH-FDH 3 4
  • FALDH 3 4
  • ADHX 3 4
  • FDH 3 4
  • Alcohol Dehydrogenase (Class III), Chi Polypeptide 3
  • Epididymis Secretory Sperm Binding Protein Li 60p 3
  • Alcohol Dehydrogenase 5 4
  • EC 1.1.1.284 4
  • EC 1.1.1.- 4
  • HEL-S-60p 3
  • EC 1.1.1 63
  • ADH-3 3
  • GSNOR 3

External Ids for ADH5 Gene

Previous HGNC Symbols for ADH5 Gene

  • FDH

Previous GeneCards Identifiers for ADH5 Gene

  • GC04M100238
  • GC04M100385
  • GC04M100454
  • GC04M100459
  • GC04M100349
  • GC04M099992
  • GC04M095730

Summaries for ADH5 Gene

Entrez Gene Summary for ADH5 Gene

  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ADH5 Gene

ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include sjogren-larsson syndrome and methanol poisoning. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include protein homodimerization activity and electron carrier activity. An important paralog of this gene is ADH6.

UniProtKB/Swiss-Prot for ADH5 Gene

  • Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Gene Wiki entry for ADH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene

Genomics for ADH5 Gene

Regulatory Elements for ADH5 Gene

Genomic Location for ADH5 Gene

Chromosome:
4
Start:
99,070,978 bp from pter
End:
99,088,801 bp from pter
Size:
17,824 bases
Orientation:
Minus strand

Genomic View for ADH5 Gene

Genes around ADH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH5 Gene

Proteins for ADH5 Gene

  • Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11766-ADHX_HUMAN
    Recommended name:
    Alcohol dehydrogenase class-3
    Protein Accession:
    P11766
    Secondary Accessions:
    • Q6FHR2

    Protein attributes for ADH5 Gene

    Size:
    374 amino acids
    Molecular mass:
    39724 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH5 Gene

neXtProt entry for ADH5 Gene

Proteomics data for ADH5 Gene at MOPED

Post-translational modifications for ADH5 Gene

  • Ubiquitination at Lys 101, Lys 113, Lys 228, Lys 233, Lys 323, and Lys 366
  • Modification sites at PhosphoSitePlus

Other Protein References for ADH5 Gene

Antibody Products

Domains & Families for ADH5 Gene

Gene Families for ADH5 Gene

Graphical View of Domain Structure for InterPro Entry

P11766

UniProtKB/Swiss-Prot:

ADHX_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
genes like me logo Genes that share domains with ADH5: view

Function for ADH5 Gene

Molecular function for ADH5 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Enzyme Numbers (IUBMB) for ADH5 Gene

Gene Ontology (GO) - Molecular Function for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0018467 formaldehyde dehydrogenase activity IDA 8460164
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity IEA,TAS 8460164
genes like me logo Genes that share ontologies with ADH5: view
genes like me logo Genes that share phenotypes with ADH5: view

Animal Models for ADH5 Gene

MGI Knock Outs for ADH5:

Animal Model Products

miRNA for ADH5 Gene

miRTarBase miRNAs that target ADH5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADH5 Gene

Localization for ADH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH5 Gene COMPARTMENTS Subcellular localization image for ADH5 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ADH5 Gene

Pathways & Interactions for ADH5 Gene

genes like me logo Genes that share pathways with ADH5: view

Gene Ontology (GO) - Biological Process for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA --
GO:0006069 ethanol oxidation IEA,TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0018119 peptidyl-cysteine S-nitrosylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ADH5: view

No data available for SIGNOR curated interactions for ADH5 Gene

Drugs & Compounds for ADH5 Gene

(20) Drugs for ADH5 Gene - From: Novoseek, DrugBank, HMDB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 1839
Zinc Approved Pharma 1477
Vitamin A Approved Nutra 413
Choline Approved Nutra 130
12-Hydroxydodecanoic acid Experimental Pharma Target 0

(45) Additional Compounds for ADH5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(2-Naphthyl)methanol
1-Hydroxymethylnaphthalene
1-Naphthaldehyde
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8
genes like me logo Genes that share compounds with ADH5: view

Transcripts for ADH5 Gene

Unigene Clusters for ADH5 Gene

Alcohol dehydrogenase 5 (class III), chi polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH5 Gene

No ASD Table

Relevant External Links for ADH5 Gene

GeneLoc Exon Structure for
ADH5
ECgene alternative splicing isoforms for
ADH5

Expression for ADH5 Gene

mRNA expression in normal human tissues for ADH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADH5 Gene



SOURCE GeneReport for Unigene cluster for ADH5 Gene Hs.78989

genes like me logo Genes that share expression patterns with ADH5: view

Protein tissue co-expression partners for ADH5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADH5 Gene

Orthologs for ADH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADH5 35
  • 90.82 (n)
  • 94.92 (a)
ADH5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADH5 35
  • 92.6 (n)
  • 94.92 (a)
-- 36
  • 74 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
ADH5 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adh5 35
  • 88.59 (n)
  • 93.05 (a)
Adh5 16
Adh5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADH5 35
  • 99.73 (n)
  • 99.47 (a)
ADH5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adh5 35
  • 88.24 (n)
  • 94.39 (a)
oppossum
(Monodelphis domestica)
Mammalia ADH5 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADH5 35
  • 79.41 (n)
  • 87.17 (a)
ADH5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADH5 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adh5 35
  • 76.7 (n)
  • 86.56 (a)
zebrafish
(Danio rerio)
Actinopterygii adh5 35
  • 73.14 (n)
  • 81.67 (a)
adh8a 36
  • 61 (a)
ManyToMany
adh8b 36
  • 56 (a)
ManyToMany
zgc:63568 36
  • 62 (a)
ManyToMany
zgc:77938 36
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 37
  • 71 (a)
Fdh 35
  • 66.22 (n)
  • 71.89 (a)
Fdh 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010499 35
  • 66.76 (n)
  • 74.71 (a)
worm
(Caenorhabditis elegans)
Secernentea H24K24.3a 37
  • 69 (a)
H24K24.3b 37
  • 68 (a)
Y50D4C.2 37
  • 67 (a)
H24K24.3 35
  • 64.24 (n)
  • 69.81 (a)
H24K24.3 36
  • 67 (a)
ManyToMany
Y50D4C.2 36
  • 43 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL148C 35
  • 58.08 (n)
  • 63.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12342g 35
  • 61.13 (n)
  • 61.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 35
  • 61.32 (n)
  • 63.86 (a)
SFA1 36
  • 60 (a)
OneToMany
SFA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HOT5 35
  • 64.77 (n)
  • 69.38 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2516 35
rice
(Oryza sativa)
Liliopsida Os02g0815500 35
  • 63.87 (n)
  • 67.48 (a)
corn
(Zea mays)
Liliopsida Zm.2742 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14208 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06652 35
  • 59.3 (n)
  • 64.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC13B11.04c 35
  • 61.84 (n)
  • 64.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 71 (a)
OneToMany
Species with no ortholog for ADH5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH5 Gene

ENSEMBL:
Gene Tree for ADH5 (if available)
TreeFam:
Gene Tree for ADH5 (if available)

Paralogs for ADH5 Gene

Paralogs for ADH5 Gene

Pseudogenes.org Pseudogenes for ADH5 Gene

genes like me logo Genes that share paralogs with ADH5: view

Variants for ADH5 Gene

Sequence variations from dbSNP and Humsavar for ADH5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs28730623 - 99,076,780(-) TCCTT(A/C/G/T)AGCAC reference, missense
rs28730628 - 99,074,950(-) AGCTG(A/G)TAACA reference, missense
rs16996593 - 99,072,614(+) ATTTC(A/C)TCAAA reference, missense
rs12106 -- 99,072,199(-) GCTAG(C/T)TTATT utr-variant-3-prime
rs12697 -- 99,072,225(-) CTGGA(C/T)GCTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADH5 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294

Variation tolerance for ADH5 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADH5 Gene

HapMap Linkage Disequilibrium report
ADH5
Human Gene Mutation Database (HGMD)
ADH5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH5 Gene

Disorders for ADH5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ADH5 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sjogren-larsson syndrome
  • sjogren larsson syndrome
methanol poisoning
pharyngitis
  • acute sore throat
papilledema
  • choked disk
fetal alcohol spectrum disorder
  • fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ADH5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH5

Genetic Association Database (GAD)
ADH5
Human Genome Epidemiology (HuGE) Navigator
ADH5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH5
genes like me logo Genes that share disorders with ADH5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH5 Gene

Publications for ADH5 Gene

  1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur M.W. … Edenberg H.J. (Gene 1992) 2 3 4 23 67
  2. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H. … London S.J. (J. Allergy Clin. Immunol. 2007) 3 23
  3. Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids. (PMID: 17092593) Okochi M. … Honda H. (J. Biotechnol. 2007) 23 25
  4. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. (PMID: 16792560) Lee S.L. … Yin S.J. (Alcohol. Clin. Exp. Res. 2006) 25 26
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for ADH5 Gene

Sources for ADH5 Gene

Back to Top

Content