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ADH5 Gene

protein-coding GIFtS: 66

GC04M100238

alcohol dehydrogenase 5 (class III), chi polypeptide
(Previous name: formaldehyde dehydrogenase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FDH)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADH-3 ^¹, ²
ADHX ^¹, ², ³
EC 1.1.1.1,EC 1.1.1.284,EC 1.1.1.- ^³
FALDH ^³
FDH ^², ³, ⁵
GSH-FDH ^³
GSNOR ^²

Descriptions
Alcohol dehydrogenase 5 ^³
Alcohol dehydrogenase class chi chain ^³
Alcohol dehydrogenase class-III ^³
Glutathione-dependent formaldehyde dehydrogenase ^², ³
S-(hydroxymethyl)glutathione dehydrogenase ^³
alcohol dehydrogenase (class III), chi polypeptide ^²
alcohol dehydrogenase 5 (class III), chi polypeptide ^²
alcohol dehydrogenase 5, chi polypeptide ^²
formaldehyde dehydrogenase ^¹, ²

External Ids
HGNC: 253¹
Entrez Gene: 128²
UniProtKB: P11766³
Ensembl: ENSG00000197894⁷

Search outside databases for aliases for ADH5 gene

Previous GC identifers: GC04M100385 GC04M100454 GC04M100459 GC04M100349

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADH5:

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a

wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids,

and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no

activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary

alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between

formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the

elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation,

rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed

pseudogenes related to this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766

Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes

the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Gene Wiki entry for ADH5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADH5 gene

Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100238: (about GC identifiers)

Start:	100,211,152 bp from pter
End:	100,240,090 bp from pter
Size:	28,939 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766 (See protein sequence)

Recommended Name: Alcohol dehydrogenase class-3

Size: 374 amino acids; 39724 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Homodimer

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha,

beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to

class-V: ADH6

PDB structures from and Proteopedia :

1M6H (3D)

1M6W (3D)

1MA0 (3D)

1MC5 (3D)

1MP0 (3D)

1TEH (3D)

2FZE (3D)

2FZW (3D)

Secondary accessions: Q6FHR2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000662.3

ENSEMBL proteins:

ENSP00000296412

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADH5)
	Human Recombinant Proteins from Abnova (ADH5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IEA	--

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Antibodies for ADH5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADH5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADH5)
	Novus Biologicals Antibodies for ADH5

Assays for ADH5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P11766

ProtoNet protein and cluster: P11766

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000671

Applied Biosystems Silencer® siRNAs for ADH5

Sigma-Aldrich siRNA and siRNA Panels for ADH5

Sigma-Aldrich shRNA for ADH5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADH5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000671
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000671
untagged cDNA clones in CMV expression vector (see all 2): NM_000671

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000671

UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766

Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes

the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Catalytic activity: S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H

Enzyme Number (IUBMB): EC 1.1.1.1,EC

Genatlas biochemistry entry for ADH5:

alcohol dehydrogenase (class III),chi polypeptide (see ADH@)

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adh5):

homeostasis/metabolism

immune system

life span-post-weaning/aging

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004022	alcohol dehydrogenase activity	IEA	--
GO:0005488	binding	IEA	--
GO:0005504	fatty acid binding	IDA	8460164
GO:0008270	zinc ion binding	IDA	6375718
GO:0009055	electron carrier activity	TAS	8460164

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ADH5 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Fatty Acid Metabolism
Tyrosine Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Bile Acid Biosynthesis
Glycolysis/Gluconeogenesis

GeneDecks ADH5 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADH5

5/42 Interacting proteins for ADH5 (P11766² ENSP00000296412³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHD3	Q12873²	MINT-63459
ADHFE1	ENSP00000276576³	STRING (score=.963)
ALDH1B1	ENSP00000366927³	STRING (score=.931)
ALDH2	ENSP00000261733³	STRING (score=.931)
ALDH3A1	ENSP00000334590³	STRING (score=.931)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001523	retinoid metabolic process	IEA	--
GO:0003016	respiratory system process	IEA	--
GO:0006069	ethanol oxidation	IEA	--
GO:0018119	peptidyl-cysteine S-nitrosylation	IEA	--
GO:0032496	response to lipopolysaccharide	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADH5
10/20 Novoseek chemical compound relationships for ADH5 gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
8-thio-octanoate	92.02	1	7485831 (1)
12-hydroxydodecanoic acid	91.91	1	8494891 (1)
10-formyltetrahydrofolate	87.32	23	16597835 (3), 18848533 (3), 12684508 (2), 11320079 (2) (see all 5)
mycothiol	78.05	2	12209256 (1), 10609883 (1)
tetrahydrofolate	71.40	6	12209256 (1), 16712799 (1), 18848533 (1), 11320079 (1)
nad+	61.08	4	9531510 (1), 11038276 (1), 17098416 (1)
nadh	57.48	2	10699858 (1), 17092593 (1)
ethanol	56.22	11	12782305 (3), 11054102 (1), 8612630 (1), 7598661 (1) (see all 7)
methylamine	50.55	3	11038276 (2)
hydride	40.92	1	15627379 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000671

Sigma-Aldrich siRNA and siRNA Panels for ADH5

Sigma-Aldrich shRNA for ADH5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000671

REFSEQ mRNAs for ADH5 gene:

NM_000671.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000671

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000671
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000671
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000671

Additional cDNA sequence:

AK124994.1 AK129570.1 AK226177.1 AK312367.1 BC014665.1 BC070491.1 BT019832.1 BT019833.1

CR536491.1 CR541689.1 CR590837.1 CR592134.1 CR593976.1 CR598204.1 CR603698.1 CR606065.1

CR616221.1 CR617310.1 CR619952.1 CR622943.1 CR625434.1 CR625527.1 M29872.1 M30471.1

24/25 DOTS entries (see all 25 ):

DT.449820 DT.97795127 DT.121224230 DT.100865484 DT.92452643 DT.100865495 DT.100865478 DT.92452641

DT.100865499 DT.121224148 DT.121224168 DT.40211879 DT.100865498 DT.100865482 DT.100031725 DT.100865486

DT.101984557 DT.100865503 DT.121224112 DT.100865500 DT.121224295 DT.92414394 DT.92452644 DT.100031720

24/570 AceView cDNA sequences (see all 570 ):

BG775256 BF038336 AL535009 AI127077 BQ436206 BU167762 CD721987 AW104095

BG033342 CR536491 BM849265 BE855537 CR619952 CA424815 CA310028 BE464374

CA441045 BG744349 AL538331 CB215846 BQ182013 BM836352 BE855625 CR593976

highest scoring ESTs for ADH5:

AA376989 AI444624 AI929349 AU279477 BC014665 BC070491 BE019767 BE278525 BE538100 BE559997

Unigene Cluster for ADH5:

Alcohol dehydrogenase 5 (class III), chi polypeptide

Hs.78989 [show with all ESTs]

Unigene Representative Sequence: AK226177

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000296412

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADH5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADH5

¹ / ² / ³

6 probe-sets matching ADH5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37708_r_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.89	M81118	0.20	1.00	0.72	1
37707_i_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.11	M81118	0.20	1.00	0.72	1
208848_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M30471	0.80	1.00	0.91	1
208847_s_at²^{, 3}	U133-A	5	1.00	0.85	--	--	M29872	0.80	1.00	0.91	1
208848_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208847_s_at²	U133Plus2	5	1.00	0.85	--	--	--	--	--	--	--

GeneDecks ADH5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCTGTTTT

SOURCE GeneReport for Unigene cluster: Hs.78989
Expression variation in blood from EXPOLDB for ADH5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADH5 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADH5¹	--	alcohol dehydrogenase 5 (class III), chi polypeptide	99.73(n) 99.47(a)	743928 XM_001166206.1 XP_001166206.1
cow (Bos taurus)	ADH5¹	--	alcohol dehydrogenase 5 (class III), chi polypeptide	90.82(n) 94.92(a)	505515 NM_001034249.1 NP_001029421.1
mouse (Mus musculus)	Adh5^{1, 5}	3⁵	alcohol dehydrogenase 5 (class III), chi polypeptide^{1, 5}	88.59(n)¹ 93.05(a)¹	11532¹ NM_007410.2¹ NP_031436.2¹ AC079832⁵ AK002790⁵ (see all 22)
chicken (Gallus gallus)	ADH5¹	--	alcohol dehydrogenase 5 (class III), chi polypeptide	79.45(n) 87.4(a)	422705 NM_001031152.1 NP_001026323.1
zebrafish (Danio rerio)	adh5²	--	alcohol dehydrogenase 5	74.57(n)	116517 AF399909.1

About this table Species with no ortholog for ADH5

ENSEMBL Gene Tree for ADH5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADH5 gene

ADH1C² ADH4² ADH1B² ADH7²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/271 NCBI SNPs in ADH5 are shown (see all 271 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 122)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1154400^1,2	A,C,F,H,O	100229033(+)	`CGTGCT/CGCTAA`	1	--	ng3¹		19	EA NA NS EU WA	1170
--	rs1803037^1,2	C,F,H,O	100212174(-)	`TCCCCG/ATTGAT`	1	--	ut3¹		16	NA NS EU EA WA	1140
--	rs13832^1,2	A,C,F,H	100212098(-)	`ATCTTT/GAAGGG`	1	--	ut3¹		11	MN EU EA WA NS	972
	rs7669660^1,2	A,C,F,H	100211625(+)	`aattaT/Cggtag`	1	--	ut3¹		16	EU EA WA NA NS	1152
--	rs1061187^1,2	C,F,H	100211876(-)	`CACTTC/TGAGAT`	1	--	ut3¹		13	NA MN NS EU EA WA	920
--	rs12106^1,2	C,F,O	100212373(-)	`GCTAGT/CTTATT`	1	--	ut3¹		7	MN NS	552
--	rs11547772^1,2	C,F,H	100211816(+)	`GAATGA/CTAAAC`	1	--	ut3¹		12	NA NS EU EA WA	736
	rs7667261^1,2	C,F,H	100230323(+)	`CCTAGC/GCAGAA`	1	--	ng3¹		9	EU EA WA NS	602
--	rs2851301^1,2	C,F,H	100229150(+)	`CTTCCC/TYGTGT`	1	--	ng3¹ tfbs³		10	MN EA WA NS	820
--	rs11568816^1,2	C,F,H	100228946(-)	`CTCGCC/TACGCC`	1	--	ut5¹		9	EU EA WA NS	610

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HapMap Linkage Disequilibrium images for ADH5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 103710

1 Novoseek disease relationship for ADH5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	1.53	2	11471570 (1), 11073833 (1)

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Human Gene Mutation Database: ADH5
Human Genome Epidemiology Navigator: ADH5 (6 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/119 PubMed articles for ADH5 gene (see all 119 ):

Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PubMed id 1446828)^{1, 2, 3, 4} Hur M.W. and Edenberg H.J. (1992)
Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PubMed id 8494891)^{1, 3, 4} Holmquist B.... Vallee B.L. (1993)
Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PubMed id 8460164)^{1, 3, 4} Engeland K....Vallee B.L. (1993)
Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (PubMed id 9018047)^{1, 3, 4} Yang Z.-N.... Hurley T.D. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
cDNA sequence of human class III alcohol dehydrogenase. (PubMed id 2818582)^{3, 4} Sharma C.P.... Vallee B.L. (1989)
Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. (PubMed id 2679557)^{3, 4} Giri P.R.... Goldman D. (1989)
Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. (PubMed id 3365377)^{3, 4} Kaiser R.... Joernvall H. (1988)
Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme. (PubMed id 6424546)^{2, 3} Adinolfi A....Hopkinson D.A. (1984)
Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. (PubMed id 12484756)^{1, 3} Sanghani P.C....Hurley T.D. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 128	HGNC: 253	AceView: ADH5	Ensembl:ENSG00000197894	euGenes: HUgn128
ECgene: ADH5	H-InvDB: ADH5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh5/

Licensable Technologies for ADH5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADH5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADH5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADH5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADH5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for ADH5

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADH5 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADH5

Summaries
for ADH5

Genomic Location
for ADH5

Proteins
for ADH5

Protein Domains/
Families
for ADH5

Gene Function
for ADH5

Pathways & Interactions
for ADH5

Drugs & Compounds
for ADH5

Transcripts
for ADH5

Expression
for ADH5

Orthologs
for ADH5

Paralogs
for ADH5

SNPs/Variants
for ADH5

Disorders & Mutations
for ADH5

Medical News
for ADH5

Publications
for ADH5

Search for ADH5

Genome Databases showing ADH5

Other Databases showing ADH5

Specialized Databases showing ADH5

Licensable Technologies
for ADH5

Services
for ADH5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADH5 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADH5

Summariesfor ADH5

Genomic Locationfor ADH5

Proteinsfor ADH5

Protein Domains/Familiesfor ADH5

Gene Functionfor ADH5

Pathways & Interactionsfor ADH5

Drugs & Compoundsfor ADH5

Transcriptsfor ADH5

Expression for ADH5

Orthologsfor ADH5

Paralogsfor ADH5

SNPs/Variantsfor ADH5

Disorders & Mutationsfor ADH5

Medical Newsfor ADH5

Publicationsfor ADH5

Search for ADH5

Genome Databases showing ADH5

Other Databases showing ADH5

Specialized Databases showing ADH5

Licensable Technologiesfor ADH5

Servicesfor ADH5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADH5

Summaries
for ADH5

Genomic Location
for ADH5

Proteins
for ADH5

Protein Domains/
Families
for ADH5

Gene Function
for ADH5

Pathways & Interactions
for ADH5

Drugs & Compounds
for ADH5

Transcripts
for ADH5

Expression
for ADH5

Orthologs
for ADH5

Paralogs
for ADH5

SNPs/Variants
for ADH5

Disorders & Mutations
for ADH5

Medical News
for ADH5

Publications
for ADH5

Licensable Technologies
for ADH5

Services
for ADH5