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Aliases for ADH5 Gene

Aliases for ADH5 Gene

  • Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide 2 3
  • FDH 3 4 6
  • Glutathione-Dependent Formaldehyde Dehydrogenase 3 4
  • S-(Hydroxymethyl)Glutathione Dehydrogenase 3 4
  • Alcohol Dehydrogenase Class Chi Chain 3 4
  • Alcohol Dehydrogenase Class-III 3 4
  • Formaldehyde Dehydrogenase 2 3
  • EC 4 64
  • GSH-FDH 3 4
  • FALDH 3 4
  • ADHX 3 4
  • Alcohol Dehydrogenase (Class III), Chi Polypeptide 3
  • Alcohol Dehydrogenase Class-3 3
  • Alcohol Dehydrogenase 5 4
  • EC 4
  • EC 1.1.1.- 4
  • EC 1.1.1 64
  • ADH-3 3
  • GSNOR 3

External Ids for ADH5 Gene

Previous Symbols for ADH5 Gene

  • FDH

Summaries for ADH5 Gene

Entrez Gene Summary for ADH5 Gene

  • This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ADH5 Gene

ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include methanol poisoning and contact dermatitis. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include protein homodimerization activity and fatty acid binding. An important paralog of this gene is ADH6.

UniProtKB/Swiss-Prot for ADH5 Gene

  • Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Gene Wiki entry for ADH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH5 Gene

Genomics for ADH5 Gene

Genomic Location for ADH5 Gene

99,070,978 bp from pter
99,088,801 bp from pter
17,824 bases
Minus strand

Genomic View for ADH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH5 Gene

Regulatory Elements for ADH5 Gene

Proteins for ADH5 Gene

  • Protein details for ADH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alcohol dehydrogenase class-3
    Protein Accession:
    Secondary Accessions:
    • Q6FHR2

    Protein attributes for ADH5 Gene

    374 amino acids
    Molecular mass:
    39724 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Homodimer
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

    Three dimensional structures from OCA and Proteopedia for ADH5 Gene

neXtProt entry for ADH5 Gene

Proteomics data for ADH5 Gene at MOPED

Post-translational modifications for ADH5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys101, Lys113, Lys228, Lys233, Lys323, and Lys366

Other Protein References for ADH5 Gene

Domains for ADH5 Gene

Gene Families for ADH5 Gene

  • ADH :Alcohol dehydrogenases


  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.:
    • P11766
genes like me logo Genes that share domains with ADH5: view

Function for ADH5 Gene

Molecular function for ADH5 Gene

GENATLAS Biochemistry: alcohol dehydrogenase (class III),chi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH
UniProtKB/Swiss-Prot CatalyticActivity: S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H
UniProtKB/Swiss-Prot Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Enzyme Numbers (IUBMB) for ADH5 Gene

Gene Ontology (GO) - Molecular Function for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IEA --
GO:0005504 fatty acid binding IDA 8460164
GO:0008270 zinc ion binding IDA 6375718
GO:0009055 electron carrier activity TAS 8460164
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with ADH5: view
genes like me logo Genes that share phenotypes with ADH5: view

Animal Models for ADH5 Gene

MGI Knock Outs for ADH5:

miRNA for ADH5 Gene

miRTarBase miRNAs that target ADH5

No data available for Transcription Factor Targeting and HOMER Transcription for ADH5 Gene

Localization for ADH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH5 Gene


Subcellular locations from

Jensen Localization Image for ADH5 Gene COMPARTMENTS Subcellular localization image for ADH5 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ADH5: view

Pathways for ADH5 Gene

genes like me logo Genes that share pathways with ADH5: view

Pathways by source for ADH5 Gene

Gene Ontology (GO) - Biological Process for ADH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process IEA --
GO:0003016 respiratory system process IEA --
GO:0006068 ethanol catabolic process IEA --
GO:0006069 ethanol oxidation IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with ADH5: view

Compounds for ADH5 Gene

(19) HMDB Compounds for ADH5 Gene

Compound Synonyms Cas Number PubMed IDs
  • 3,4-Dihydroxyphenylglycolaldehyde
  • (3,4-Dihydroxyphenyl)ethylene glycol
  • 3a,7a-Dihydroxy-5b-cholestan-26-al
Not Available
  • 9-cis-Retinal
  • acetaldehyde

(5) Drugbank Compounds for ADH5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
12-Hydroxydodecanoic Acid
505-95-3 target
  • beta-DPNH
606-68-8 target
  • beta-DPNH
606-68-8 enzyme substrate
53-84-9 target
S-Hydroxymethyl Glutathione

(32) Novoseek inferred chemical compound relationships for ADH5 Gene

Compound -log(P) Hits PubMed IDs
8-thio-octanoate 91.8 1
12-hydroxydodecanoic acid 91.7 1
10-formyltetrahydrofolate 88.2 13
formaldehyde 85 63
gsno 81.2 12
genes like me logo Genes that share compounds with ADH5: view

Transcripts for ADH5 Gene

Unigene Clusters for ADH5 Gene

Alcohol dehydrogenase 5 (class III), chi polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH5 Gene

No ASD Table

Relevant External Links for ADH5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADH5 Gene

mRNA expression in normal human tissues for ADH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADH5 Gene

SOURCE GeneReport for Unigene cluster for ADH5 Gene Hs.78989

genes like me logo Genes that share expressions with ADH5: view

Orthologs for ADH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADH5 36
  • 99.73 (n)
  • 99.47 (a)
ADH5 37
  • 99 (a)
(Bos Taurus)
Mammalia ADH5 36
  • 90.82 (n)
  • 94.92 (a)
ADH5 37
  • 95 (a)
(Canis familiaris)
Mammalia -- 37
  • 74 (a)
-- 37
  • 94 (a)
ADH5 36
  • 92.6 (n)
  • 94.92 (a)
ADH5 37
  • 95 (a)
(Mus musculus)
Mammalia Adh5 36
  • 88.59 (n)
  • 93.05 (a)
Adh5 16
Adh5 37
  • 93 (a)
(Monodelphis domestica)
Mammalia ADH5 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Adh5 36
  • 88.24 (n)
  • 94.39 (a)
(Gallus gallus)
Aves ADH5 36
  • 79.41 (n)
  • 87.17 (a)
ADH5 37
  • 87 (a)
(Anolis carolinensis)
Reptilia ADH5 37
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adh5 36
  • 76.7 (n)
  • 86.56 (a)
(Danio rerio)
Actinopterygii adh5 36
  • 73.14 (n)
  • 81.67 (a)
adh8a 37
  • 61 (a)
adh8b 37
  • 56 (a)
zgc:63568 37
  • 62 (a)
zgc:77938 37
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010499 36
  • 66.76 (n)
  • 74.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 66.22 (n)
  • 71.89 (a)
Fdh 37
  • 70 (a)
Fdh 38
  • 71 (a)
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 64.24 (n)
  • 69.81 (a)
H24K24.3 37
  • 67 (a)
Y50D4C.2 37
  • 43 (a)
H24K24.3a 38
  • 69 (a)
Y50D4C.2 38
  • 67 (a)
H24K24.3b 38
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL148C 36
  • 58.08 (n)
  • 63.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 61.32 (n)
  • 63.86 (a)
SFA1 37
  • 60 (a)
SFA1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12342g 36
  • 61.13 (n)
  • 61.93 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HOT5 36
  • 64.77 (n)
  • 69.38 (a)
(Hordeum vulgare)
Liliopsida Hv.2516 36
(Zea mays)
Liliopsida Zm.2742 36
(Oryza sativa)
Liliopsida Os02g0815500 36
  • 63.87 (n)
  • 67.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06652 36
  • 59.3 (n)
  • 64.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC13B11.04c 36
  • 61.84 (n)
  • 64.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14208 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 37
  • 71 (a)
Species with no ortholog for ADH5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH5 Gene

Gene Tree for ADH5 (if available)
Gene Tree for ADH5 (if available)

Paralogs for ADH5 Gene

Paralogs for ADH5 Gene

Selected SIMAP similar genes for ADH5 Gene using alignment to 9 proteins: Pseudogenes for ADH5 Gene

genes like me logo Genes that share paralogs with ADH5: view

Variants for ADH5 Gene

Sequence variations from dbSNP and Humsavar for ADH5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12106 -- 99,072,199(-) GCTAG(C/T)TTATT utr-variant-3-prime
rs12697 -- 99,072,225(-) CTGGA(C/T)GCTCC utr-variant-3-prime
rs13832 -- 99,071,924(-) ATCTT(G/T)AAGGG utr-variant-3-prime
rs896992 -- 99,081,221(+) TTGTT(C/T)GGGAC intron-variant
rs1050636 -- 99,076,769(-) CTTTG(G/T)ATAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADH5 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294

Relevant External Links for ADH5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ADH5 Gene

(1) University of Copenhagen DISEASES for ADH5 Gene

(1) Novoseek inferred disease relationships for ADH5 Gene

Disease -log(P) Hits PubMed IDs
tumors 1.47 2

Relevant External Links for ADH5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADH5: view

No data available for UniProtKB/Swiss-Prot for ADH5 Gene

Publications for ADH5 Gene

  1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PMID: 1446828) Hur M.W. … Edenberg H.J. (Gene 1992) 2 3 4 23
  2. Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (PMID: 9018047) Yang Z.-N. … Hurley T.D. (J. Mol. Biol. 1997) 3 4 23
  3. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PMID: 8494891) Holmquist B. … Vallee B.L. (Biochemistry 1993) 3 4 23
  4. Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PMID: 8460164) Engeland K. … Vallee B.L. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  5. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. (PMID: 17543375) Wu H. … London S.J. (J. Allergy Clin. Immunol. 2007) 3 23 49

Products for ADH5 Gene

Sources for ADH5 Gene

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