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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADH5 Gene

protein-coding   GIFtS: 65
GCID: GC04M099992

alcohol dehydrogenase 5 (class III), chi polypeptide

(Previous name: formaldehyde dehydrogenase )
(Previous symbol: FDH)
 Explore 25 diseases affiliated with
ADH5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADH5    

Aliases
for ADH5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide1 2     S-(Hydroxymethyl)Glutathione Dehydrogenase2 3
FDH1 2 3 5     EC 1.1.1.13 8
ADHX1 2 3     GSNOR2
ADH-31 2     Alcohol Dehydrogenase (Class III), Chi Polypeptide2
Formaldehyde Dehydrogenase1 2     Alcohol Dehydrogenase Class-32
Alcohol Dehydrogenase Class Chi Chain2 3     EC 1.1.1.-3
Alcohol Dehydrogenase Class-III2 3     EC 1.1.1.2843
Glutathione-Dependent Formaldehyde Dehydrogenase2 3     Alcohol Dehydrogenase 53
FALDH2 3     EC 1.1.18
GSH-FDH2 3     

External Ids:    HGNC: 2531   Entrez Gene: 1282   Ensembl: ENSG000001978947   OMIM: 1037105   UniProtKB: P117663   

Export aliases for ADH5 gene to outside databases

Previous GC identifers: GC04M100238 GC04M100385 GC04M100454 GC04M100459 GC04M100349 GC04M095730


Summaries
for ADH5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADH5:
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of
substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.
The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity
for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct
between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination
of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact
dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. (provided by RefSeq,
Oct 2008)

UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766
Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of
long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Gene Wiki entry for ADH5


Genomic Views
for ADH5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADH5 gene promoter:
         SREBP-1c   MEF-2   AP-4   MEF-2A   S8   ARP-1   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADH5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M099992:  view genomic region     (about GC identifiers)

Start:
 99,992,129 bp from pter      End:
 100,009,952 bp from pter
Size:
 17,824 bases      Orientation:
 minus strand

Proteins
for ADH5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766 (See protein sequence)
Recommended Name: Alcohol dehydrogenase class-3  
Size: 374 amino acids; 39724 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to
class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
6/9 PDB 3D structures from and Proteopedia for ADH5 (see all 9):
1M6H (3D)        1M6W (3D)        1MA0 (3D)        1MC5 (3D)        1MP0 (3D)        1TEH (3D)    
Secondary accessions: Q6FHR2

Explore the universe of human proteins at neXtProt for ADH5: NX_P11766

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11766

    • 4/15 DME Specific Peptides for ADH5 (P11766) (see all 15)
     AGASRII  RFTCKGK  EMTDGGV  GVDYSFE 

    ADH5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000662.3  
    ENSEMBL proteins: 
     ENSP00000296412   ENSP00000424650   ENSP00000427049   ENSP00000422119   ENSP00000421556  
     ENSP00000427026  

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    ProSpec Recombinant Protein for ADH5
    Uscn Proteins for ADH5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--


    ADH5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADH5

    Protein Domains /
    Families
    for ADH5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADH5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR002328 ADH_Zn_CS
     IPR013154 ADH_GroES-like

    Graphical View of Domain Structure for InterPro Entry P11766

    ProtoNet protein and cluster: P11766

    2 Blocks protein families:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily


    Function
    for ADH5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADHX_HUMAN, P11766
    Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of
    long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH
    Catalytic activity: S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H

         Genatlas biochemistry entry for ADH5:
    alcohol dehydrogenase (class III),chi polypeptide (see ADH@)

    Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12 EC 1.1.1.-1 EC 1.1.1.2841

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ADH5:
    hsa-miR-944 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ADH5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADH5 (see all 7)
    OriGene shRNA RFP: ADH5
    OriGene siRNA: ADH5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADH5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADH5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADH5 (see all 3)
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004022alcohol dehydrogenase (NAD) activity IEA--
    GO:0005504fatty acid binding IDA8460164
    GO:0008270zinc ion binding IDA6375718
    GO:0009055electron carrier activity TAS8460164


    ADH5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADH5:
     Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for ADH5: Adh5tm1Gdu Adh5tm1Stam
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adh5):
     cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 

    ADH5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADH5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    2Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    3formaldehyde oxidation II (glutathione-dependent)
    		formaldehyde oxidation II (glutathione-dependent)1.00
    4Tyrosine metabolism
    		Tyrosine metabolism1.00
    5Ethanol oxidation
    		Cyclophosphamide Pathway, Pharmacodynamics0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ADH5
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

    1 BioSystems Pathway for ADH5 
        formaldehyde oxidation II (glutathione-dependent)

    1 PharmGKB Pathway for ADH5
        Cyclophosphamide Pathway, Pharmacodynamics

    5/7         Kegg Pathways  (Kegg details for ADH5) (see all 7):
        Glycolysis / Gluconeogenesis
    Fatty acid metabolism
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450


    ADH5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/106 Interacting proteins for ADH5 (P117662, 3 ENSP000002964124) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63459 I2D: score=5 
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TP63Q9H3D43, ENSP000002647314I2D: score=1 STRING: ENSP00000264731
    TP73O153503, ENSP000003675454I2D: score=1 STRING: ENSP00000367545
    ESDP107683, ENSP000003679924I2D: score=1 STRING: ENSP00000367992
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process IEA--
    GO:0003016respiratory system process IEA--
    GO:0006068ethanol catabolic process IEA--
    GO:0006069ethanol oxidation IEA--
    GO:0007568aging IEA--


    ADH5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADH5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADH5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADH5

    10/19 HMDB Compounds for ADH5 (see all 19)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    4 DrugBank Compounds for ADH5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17525463 17092593 17619232 16821840
    enzymesubstrate17525463 17092593 17619232 16821840 19583966
    12-Hydroxydodecanoic Acid-- 505-95-3target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235
    S-Hydroxymethyl Glutathione-- --target--17139284 17016423

    10/32 Novoseek chemical compound relationships for ADH5 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    8-thio-octanoate 91.8 1 7485831 (1)
    12-hydroxydodecanoic acid 91.7 1 8494891 (1)
    10-formyltetrahydrofolate 88.2 25 16597835 (3), 18848533 (3), 12684508 (2), 19933275 (2) (see all 6)
    formaldehyde 85 101 14732341 (6), 2060766 (3), 12604204 (2), 19963048 (2) (see all 44)
    gsno 81.2 19 14732341 (2), 12604204 (1), 17543375 (1), 12604202 (1) (see all 11)
    mycothiol 76.5 2 12209256 (1), 10609883 (1)
    tetrahydrofolate 73.9 7 12209256 (1), 16712799 (1), 18848533 (1), 11320079 (1) (see all 5)
    formate 67.5 11 10699858 (1), 17092593 (1), 19966418 (1), 11038276 (1) (see all 9)
    nad+ 61.8 5 9531510 (1), 19966418 (1), 11038276 (1), 17098416 (1)
    nadh 58.2 3 10699858 (1), 17092593 (1), 19966418 (1)

    Search CenterWatch for drugs/clinical trials and news about ADH5 / ADHX 

    Transcripts
    for ADH5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADH5 gene: 
    NM_000671.3  

    Unigene Cluster for ADH5:

    Alcohol dehydrogenase 5 (class III), chi polypeptide
    Hs.78989  [show with all ESTs]
    Unigene Representative Sequence: AK226177
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296412(uc003hui.3) ENST00000512621 ENST00000512659 ENST00000508511(uc003huk.1)
    ENST00000503130 ENST00000502590 ENST00000512991 ENST00000512604 ENST00000505652
    ENST00000508146 ENST00000507102 ENST00000502386

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK124994.1 AK129570.1 AK226177.1 AK312367.1 BC014665.1 BC070491.1 BT019832.1 BT019833.1 
    CR536491.1 CR541689.1 M29872.1 M30471.1 

    24/25 DOTS entries (see all 25):

    DT.449820  DT.97795127  DT.121224230  DT.100865484  DT.92452643  DT.100865495  DT.100865478  DT.92452641 
    DT.100865499  DT.121224148  DT.121224168  DT.100865498  DT.100865482  DT.100031725  DT.100865486  DT.40211879 
    DT.101984557  DT.100865503  DT.121224112  DT.100865500  DT.121224295  DT.92414394  DT.92452644  DT.100031720 

    24/570 AceView cDNA sequences (see all 570):

    BM450888 AA262352 BQ436206 BG033342 BM822505 CA427344 BM504730 AI188584 
    BQ008513 BM842648 CF618867 AL538331 CR625434 CB159158 BQ950782 BM842374 
    BP338884 AW513847 BM820162 AL555627 BF980442 BG576871 BM765353 BE855537 

    GeneLoc Exon Structure


    Expression
    for ADH5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCTGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ADH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADH5

    SOURCE GeneReport for Unigene cluster: Hs.78989
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADH5: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
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    Orthologs
    for ADH5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ADH5 gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADH51 alcohol dehydrogenase 5 (class III), chi polypeptide 79.45(n)
    87.4(a)    		   422705  NM_001031152.1  NP_001026323.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADH56
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343307.1(1468623-1477025)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CB201102.22   -- 78.98(n)    CB201102.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii adh52 alcohol dehydrogenase 5 74.57(n)   116517  AF399909.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Fdh1 , 3 alcohol dehydrogenase3
    Formaldehyde dehydrogenase1    		 71(a)3
    66.22(n)1
    71.89(a)1    		   3 86C73
    413111  NM_079586.31  NP_524310.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea H24K24.3a3
    H24K24.31    		 alcohol dehydrogenase3
    Protein H24K24.31    		 69(a)
    (best of 3)3
    64.24(n)1
    69.81(a)1    		   V(911638-915977)3
    1785971  NM_001028845.21  NP_001024016.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SFA1(YDL168W)4
    SFA11    		 Bifunctional enzyme containing both alcohol dehydrogenase more4
    Sfa1p1    		 61.41(n)1
    63.86(a)1    		   4(159604-160764)4
    8513861, 4  NP_010113.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HOT51 alcohol dehydrogenase class-3 64.77(n)
    69.38(a)    		   834417  NM_123761.3  NP_199207.1 
    rice
    (Oryza sativa)    		 Liliopsida AK099733.12   -- 70.01(n)    AK099733.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria frmA6
    yphC6
    		 alcohol dehydrogenase class III/glutathione-depend...
    predicted oxidoreductase, Zn-dependent and NAD(P)-...
    		 63(a)
    24(a)
    		 1 ↔ many
    possible ortholog
    		 Chromosome(377686-378795)
    Chromosome(2672722-2673783)


    ENSEMBL Gene Tree for ADH5 (if available)
    TreeFam Gene Tree for ADH5 (if available) 

    Paralogs
    for ADH5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADH5 gene
    ADH62  ADH42  ADH1A2  ADH1B2  ADH72  
    6 SIMAP similar genes for ADH5 using alignment to 9 protein entries:     ADHX_HUMAN (see all proteins):
    ADH4    ADH1C    ADH1B    ADH1A    ADH6    ADH7

    ADH5 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ADH5
    PGOHUM00000239543 PGOHUM00000244026 PGOHUM00000244768 PGOHUM00000245272


    Genomic Variants
    for ADH5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): ADH5
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADH5
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH5

    Disorders / Diseases
    for ADH5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADH5 for disorders           About GeneDecksing

    OMIM gene information: 103710    OMIM disorders: --

    20/25 diseases for ADH5 (see all 25):    About MalaCards
    alcoholism    contact dermatitis    johanson-blizzard syndrome    rhinitis
    dermatitis    pharyngitis    focal dermal hypoplasia    branchiooculofacial syndrome
    drug dependence    hyperthyroxinemia    aicardi syndrome    alcohol dependence
    hearing loss    adhd    hepatocellular carcinoma    pancreatic cancer
    lung cancer    asthma    pancreatitis    pneumonia

    1 Novoseek disease relationship for ADH5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.47 2 11471570 (1), 11073833 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADH5 (16 documents)

    Export disorders for ADH5 gene to outside databases

    Publications
    for ADH5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADH5 gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with ADH5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. (PubMed id 1446828)1, 2, 3, 9 Hur M.W. and Edenberg H.J. (1992)
    2. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. (PubMed id 8494891)1, 2, 9 Holmquist B.... Vallee B.L. (1993)
    3. Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. (PubMed id 8460164)1, 2, 9 Engeland K....Vallee B.L. (1993)
    4. Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (PubMed id 9018047)1, 2, 9 Yang Z.-N.... Hurley T.D. (1997)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. cDNA sequence of human class III alcohol dehydrogenase. (PubMed id 2818582)1, 2 Sharma C.P.... Vallee B.L. (1989)
    7. Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. (PubMed id 2679557)1, 2 Giri P.R.... Goldman D. (1989)
    8. Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. (PubMed id 3365377)1, 2 Kaiser R.... Joernvall H. (1988)
    9. Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme. (PubMed id 6424546)1, 3 Adinolfi A....Hopkinson D.A. (1984)
    10. Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. (PubMed id 12484756)1, 9 Sanghani P.C....Hurley T.D. (2002)

    External Searches for ADH5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADH5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128 HGNC: 253 AceView: ADH5 Ensembl:ENSG00000197894 euGenes: HUgn128
    ECgene: ADH5 Kegg: 128 H-InvDB: ADH5

    Other Databases showing ADH5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADH5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADH5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh5/

    Intellectual Property
    for ADH5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADH5 gene:
    Search GeneIP for patents involving ADH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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