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ADH4 Gene

protein-coding   GIFtS: 63
GCID: GC04M100044

Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide

  See ADH4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide1 2     Alcohol Dehydrogenase 42
Alcohol Dehydrogenase Class II Pi Chain2 3     Aldehyde Reductase2
EC 1.1.1.13 8     Epididymis Secretory Protein Li 42
ADH-22     EC 1.1.18
HEL-S-42     

External Ids:    HGNC: 2521   Entrez Gene: 1272   Ensembl: ENSG000001980997   OMIM: 1037405   UniProtKB: P083193   
ORGUL members:         

Export aliases for ADH4 gene to outside databases

Previous GC identifers: GC04M100290 GC04M100453 GC04M100458 GC04M100401 GC04M095782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADH4 Gene:
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase
family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other
aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a
homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols
and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of
alcohol dehydrogenase genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADH4 Gene:
ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) is a protein-coding gene. Diseases associated with ADH4 include alcoholic liver cirrhosis, and substance abuse. GO annotations related to this gene include NAD binding and retinol binding. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH4 gene promoter:
         c-Fos   AP-1   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   S8   E2F-1   E2F   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADH4 promoter sequence
   Search Chromatin IP Primers for ADH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q22

ADH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100044:  view genomic region     (about GC identifiers)

Start:
100,044,808 bp from pter      End:
100,078,949 bp from pter
Size:
34,142 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADH4_HUMAN, P08319 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 4  
Size: 380 amino acids; 40222 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
1 PDB 3D structure from and Proteopedia for ADH4:
3COS (3D)    
Secondary accessions: A8K470 B4DIE7 C9J4A9 Q8TCD7
Alternative splicing: 2 isoforms:  P08319-1   P08319-2   

Explore the universe of human proteins at neXtProt for ADH4: NX_P08319

Explore proteomics data for ADH4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH4 (P08319) (see all 17)
     TSLCHTD  FSQYTVV  EVAPPKA  WEAGKPL 


    See ADH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000661.2  
    ENSEMBL proteins: 
     ENSP00000424630   ENSP00000265512   ENSP00000424583   ENSP00000425416   ENSP00000426667  
     ENSP00000423571   ENSP00000427525   ENSP00000427261   ENSP00000397939  
    Reactome Protein details: P08319

    ADH4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADH4

     
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    antibodies-online proteins for ADH4 (9 products) 

     
    antibodies-online peptides for ADH4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 7):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR028632 Zinc_ADH_II

    Graphical View of Domain Structure for InterPro Entry P08319

    ProtoNet protein and cluster: P08319

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH4_HUMAN, P08319
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily


    Find genes that share domains with ADH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH4_HUMAN, P08319
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Genatlas biochemistry entry for ADH4:
    alcohol dehydrogenase (class II),pi polypeptide (see ADH@)

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003960NADPH:quinone reductase activity ISS--
    GO:0004022alcohol dehydrogenase (NAD) activity IDA16787387
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA10407146
    GO:0004032alditol:NADP+ 1-oxidoreductase activity IEA--
    GO:0004745retinol dehydrogenase activity IDA15369820
         
    Find genes that share ontologies with ADH4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADH4:
     Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADH4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADH4_HUMAN, P08319: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    chloroplast1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0015630microtubule cytoskeleton ----

    Find genes that share ontologies with ADH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADH4 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Phenylalanine metabolism
    Tyrosine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    5Cyclophosphamide Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.00


    Find genes that share SuperPaths with ADH4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ADH4
        Vitamin A and carotenoid metabolism
    noradrenaline and adrenaline degradation
    Fatty Acid Omega Oxidation

    1 Reactome Pathway for ADH4
        Ethanol oxidation

    2 PharmGKB Pathways for ADH4
        Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH4) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH4: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADH4 (P083193 ENSP000002655124) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583I2D: score=1 
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process IDA15369820
    GO:0006066alcohol metabolic process IDA3466164
    GO:0006067ethanol metabolic process ----
    GO:0006069ethanol oxidation TAS--
    GO:0006081cellular aldehyde metabolic process IDA3466164

    Find genes that share ontologies with ADH4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADH4

    9 HMDB Compounds for ADH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    3 DrugBank Compounds for ADH4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 1938903 3593480 17016423 11306066
    enzymesubstrate17139284 1938903 3593480 17016423 11306066 19583966
    Cyclohexylformamide-- --target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for ADH4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 57.6 5 12604207 (2), 11916005 (1), 19011747 (1)
    retinoid 54.8 1 11306066 (1)
    retinoic acid 43.9 2 12604207 (1), 19011747 (1)
    ethanol 30.4 7 12604207 (3), 11916005 (1), 11306066 (1), 7598661 (1)



    Find genes that share compounds with ADH4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADH4 gene: 
    NM_000670.3  

    Unigene Cluster for ADH4:

    Alcohol dehydrogenase 4 (class II), pi polypeptide
    Hs.1219  [show with all ESTs]
    Unigene Representative Sequence: AK295556
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508393(uc011ced.2) ENST00000265512(uc003hun.3) ENST00000509471
    ENST00000505590 ENST00000506705 ENST00000512499 ENST00000503416 ENST00000504125
    ENST00000503944 ENST00000504894 ENST00000504581 ENST00000423445
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    Additional mRNA sequence: 

    AK290835.1 AK295556.1 AK313649.1 BC022319.1 M15943.1 

    14 DOTS entries:

    DT.313803  DT.95160319  DT.121224116  DT.102830037  DT.92446277  DT.92446282  DT.92446275  DT.101981924 
    DT.92446278  DT.92446279  DT.121224157  DT.92446273  DT.100024083  DT.100893417 

    Selected AceView cDNA sequences (see all 75):

    CB162220 CB134869 BC022319 CB130126 AA333940 CB163762 AV682236 CB157048 
    CB137656 CB137736 CB164477 CB161793 AV691868 CB154322 CB146687 CB164064 
    AI022409 AA007395 CB161911 T29660 CD014079 CD014080 AV690677 BG567667 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADH4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                     
    SP2:              -     -     -                                                         
    SP3:              -           -                                                         
    SP4:                    -     -                                                         
    SP5:                                                                    -               


    ECgene alternative splicing isoforms for ADH4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCTGGAA
    ADH4 Expression
    About this image

    ADH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1219
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH4: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADH4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adh41 , 5 alcohol dehydrogenase 4 (class II), pi polypeptide1, 5 78.43(n)1
    72.41(a)1
      3 (64.24 cM)5
    268761  NM_011996.21  NP_036126.21 
     1384154665 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    many ↔ many
    GL343323.1(1428479-1439996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adh41 alcohol dehydrogenase 4 (class II), pi polypeptide 68.68(n)
    68.95(a)
      100488250  XM_002934773.2  XP_002934819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adh56
    zgc:779386
    (see all 5)
    zgc:77938
    (see all 5)
    64(a)
    57(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    14(45834134-45846283) ENSDARG00000080010
    14(37121611-37132341) ENSDARG00000088366
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    55(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    51(a)
    32(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFA16
    Bifunctional enzyme containing both alcohol dehydr...
    46(a)
    1 → many
    IV(159604-160764) YDL168W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ADH11 ADH1 54.04(n)
    50.13(a)
      844047  NM_106362.2  NP_177837.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02105001 Os11g0210500 52.42(n)
    49.73(a)
      4350054  NM_001074017.1  NP_001067485.1 


    ENSEMBL Gene Tree for ADH4 (if available)
    TreeFam Gene Tree for ADH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADH4 gene
    ADH1C2  ADH62  ADH1A2  ADH1B2  ADH52  ADH72  
    6 SIMAP similar genes for ADH4 using alignment to 5 protein entries:     ADH4_HUMAN (see all proteins):
    ADH5    ADH1C    ADH1B    ADH1A    ADH7    ADH6

    Find genes that share paralogs with ADH4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ADH4
    PGOHUM00000250725


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for ADH4    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11266711,2,4
    ----see VAR_0234612 mis40--------
    rs11266731,2,4
    ----see VAR_0234632 mis40--------
    rs290012191,2,4
    ----see VAR_0234622 mis40--------

    HapMap Linkage Disequilibrium report for ADH4 (100044808 - 100078949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879656CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADH4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADH4
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103740    OMIM disorders: --

    4 diseases for ADH4:    
    About MalaCards
    alcoholic liver cirrhosis    substance abuse    alcohol dependence    headache

    4 diseases from the University of Copenhagen DISEASES database for ADH4:
    Alcohol dependence     Esophageal cancer     Substance abuse     Liver disease

    Find genes that share disorders with ADH4           About GenesLikeMe

    1 Novoseek inferred disease relationship for ADH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 52 3 15863808 (1), 16571603 (1), 8583138 (1)

    Genetic Association Database (GAD): ADH4
    Human Genome Epidemiology (HuGE) Navigator: ADH4 (26 documents)

    Export disorders for ADH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADH4 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with ADH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. (PubMed id 19925625)1, 4, 9 Rainero I....Pinessi L. (Headache 2010)
    2. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PubMed id 15863808)1, 4, 9 Guindalini C....Zatz M. (Am J Psychiatry 2005)
    3. Alcohol dehydrogenase alleles in Parkinson's disease. (PubMed id 11009184)1, 4, 9 Buervenich S....Olson L. (Mov. Disord. 2000)
    4. Cloning and characterization of the human ADH4 gene. (PubMed id 1889753)1, 2, 9 von Bahr-Lindstroem H.... Hoeoeg J.-O. (Gene 1991)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (PubMed id 19861527)1, 4 Oze I....Tanaka H. (amp 2009)
    9. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    10. Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (PubMed id 19182438)1, 4 Kimura Y....Saijoh K. (J Toxicol Sci 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 127 HGNC: 252 AceView: ADH4 Ensembl:ENSG00000198099 euGenes: HUgn127
    ECgene: ADH4 Kegg: 127 H-InvDB: ADH4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADH4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADH4 gene:
    Search GeneIP for patents involving ADH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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