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Aliases for ADH1C Gene

Aliases for ADH1C Gene

  • Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide 2 3
  • ADH3 3 4 6
  • EC 1.1.1.1 4 63
  • Alcohol Dehydrogenase 3 (Class I), Gamma Polypeptide 3
  • Alcohol Dehydrogenase Subunit Gamma 4
  • Alcohol Dehydrogenase 1C 3
  • Aldehyde Reductase 3
  • ADH, Gamma Subunit 3
  • EC 1.1.1 63

External Ids for ADH1C Gene

Previous HGNC Symbols for ADH1C Gene

  • ADH3

Previous GeneCards Identifiers for ADH1C Gene

  • GC04M100504
  • GC04M100386
  • GC04M100452
  • GC04M100457
  • GC04M100614
  • GC04M100257
  • GC04M095995

Summaries for ADH1C Gene

Entrez Gene Summary for ADH1C Gene

  • This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH1C Gene

ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) is a Protein Coding gene. Diseases associated with ADH1C include alcohol dependence and liver cirrhosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH1C Gene

PharmGKB "VIP" Summary for ADH1C Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1C Gene

Genomics for ADH1C Gene

Regulatory Elements for ADH1C Gene

Genomic Location for ADH1C Gene

Start:
99,336,492 bp from pter
End:
99,353,027 bp from pter
Size:
16,536 bases
Orientation:
Minus strand

Genomic View for ADH1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1C Gene

Proteins for ADH1C Gene

  • Protein details for ADH1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00326-ADH1G_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1C
    Protein Accession:
    P00326
    Secondary Accessions:
    • Q4PJ18
    • Q5WRV0
    • Q6LBW4
    • Q6NWV0
    • Q6NZA7

    Protein attributes for ADH1C Gene

    Size:
    375 amino acids
    Molecular mass:
    39868 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

    Three dimensional structures from OCA and Proteopedia for ADH1C Gene

neXtProt entry for ADH1C Gene

Proteomics data for ADH1C Gene at MOPED

Post-translational modifications for ADH1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADH1C Gene

Gene Families for ADH1C Gene

HGNC:
  • ADH :Alcohol dehydrogenases

Suggested Antigen Peptide Sequences for ADH1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00326

UniProtKB/Swiss-Prot:

ADH1G_HUMAN :
  • P00326
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1C: view

Function for ADH1C Gene

Molecular function for ADH1C Gene

UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB) for ADH1C Gene

Gene Ontology (GO) - Molecular Function for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 6391957
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with ADH1C: view

Phenotypes for ADH1C Gene

genes like me logo Genes that share phenotypes with ADH1C: view

Animal Models for ADH1C Gene

MGI Knock Outs for ADH1C:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ADH1C Gene

Localization for ADH1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1C Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADH1C: view

No data available for Subcellular locations from COMPARTMENTS for ADH1C Gene

Pathways for ADH1C Gene

genes like me logo Genes that share pathways with ADH1C: view

Interacting Proteins for ADH1C Gene

Selected Interacting proteins: P00326-ADH1G_HUMAN for ADH1C Gene via I2D

Symbol External ID(s) Details
YWHAE

Gene Ontology (GO) - Biological Process for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with ADH1C: view

Compounds for ADH1C Gene

(17) HMDB Compounds for ADH1C Gene

Compound Synonyms Cas Number PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
28822-73-3
3a,7a-Dihydroxy-5b-cholestan-26-al
  • 3a,7a-Dihydroxy-5b-cholestan-26-al
Not Available
9-cis-Retinal
  • 9-cis-Retinal
514-85-2
Acetaldehyde
  • acetaldehyde
75-07-0

(7) Novoseek inferred chemical compound relationships for ADH1C Gene

Compound -log(P) Hits PubMed IDs
acetaldehyde 80.9 9
rsai 72.3 3
ethanol 62.5 15
formaldehyde 49.7 12
p002 21 1

(2) PharmGKB related drug/compound annotations for ADH1C Gene

Drug/compound Annotation
cisplatin CA
cyclophosphamide CA
genes like me logo Genes that share compounds with ADH1C: view

Transcripts for ADH1C Gene

Unigene Clusters for ADH1C Gene

Alcohol dehydrogenase 1C (class I), gamma polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1C Gene

No ASD Table

Relevant External Links for ADH1C Gene

GeneLoc Exon Structure for
ADH1C
ECgene alternative splicing isoforms for
ADH1C

Expression for ADH1C Gene

mRNA expression in normal human tissues for ADH1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH1C Gene

This gene is overexpressed in Liver (21.9), Colon - Transverse (10.0), and Stomach (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADH1C Gene

SOURCE GeneReport for Unigene cluster for ADH1C Gene Hs.654537

genes like me logo Genes that share expressions with ADH1C: view

No data available for mRNA Expression by UniProt/SwissProt for ADH1C Gene

Orthologs for ADH1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH1C 35
  • 99.38 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
ADH1C 35
  • 85.51 (n)
  • 84.53 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
LOC100856533 35
  • 85.96 (n)
  • 86.67 (a)
mouse
(Mus musculus)
Mammalia Adh1 35
  • 82.22 (n)
  • 85.07 (a)
Adh1 16
Adh1 36
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adh1 35
  • 81.16 (n)
  • 82.4 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 71 (a)
OneToMany
ADH1C 35
  • 70.4 (n)
  • 74.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh1c 35
  • 66.31 (n)
  • 65.68 (a)
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 54 (a)
ManyToMany
adh8b 36
  • 51 (a)
ManyToMany
zgc:63568 36
  • 56 (a)
ManyToMany
zgc:77938 36
  • 56 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 50 (a)
ManyToMany
Y50D4C.2 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 45 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.2859 35
rice
(Oryza sativa)
Liliopsida Os.12591 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 54 (a)
OneToMany
Species with no ortholog for ADH1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH1C Gene

ENSEMBL:
Gene Tree for ADH1C (if available)
TreeFam:
Gene Tree for ADH1C (if available)

Paralogs for ADH1C Gene

Paralogs for ADH1C Gene

Selected SIMAP similar genes for ADH1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADH1C: view

Variants for ADH1C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1C Gene

P00326-ADH1G_HUMAN
Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate

Sequence variations from dbSNP and Humsavar for ADH1C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs698 other, - 99,339,632(-) CAAAT(A/G/T)TTTTA reference, missense
rs166893 -- 99,354,882(+) acgtg(C/G)gagtt upstream-variant-2KB
rs172223 -- 99,350,425(-) atata(G/T)aggac intron-variant
rs283409 -- 99,342,023(-) TATTT(A/T)TTTTT intron-variant
rs283410 -- 99,343,242(-) cagaa(C/T)tactC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADH1C Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
esv2659036 CNV Deletion 23128226
nsv528518 CNV Loss 19592680
nsv293592 CNV Loss 16902084
nsv879659 CNV Gain 21882294

Relevant External Links for ADH1C Gene

HapMap Linkage Disequilibrium report
ADH1C
Human Gene Mutation Database (HGMD)
ADH1C

Disorders for ADH1C Gene

(2) OMIM Diseases for ADH1C Gene (103730)

(28) Novoseek inferred disease relationships for ADH1C Gene

Disease -log(P) Hits PubMed IDs
alcoholism 77.2 27
pharyngeal cancer 69.1 3
pancreatitis alcoholic 63 3
alcoholic cirrhosis 58.5 5
liver diseases alcoholic 57.5 5

Relevant External Links for ADH1C

Genetic Association Database (GAD)
ADH1C
Human Genome Epidemiology (HuGE) Navigator
ADH1C
genes like me logo Genes that share disorders with ADH1C: view

No data available for UniProtKB/Swiss-Prot for ADH1C Gene

Publications for ADH1C Gene

  1. Molecular structure of the human alcohol dehydrogenase 3 gene. (PMID: 1524834) Yokoyama S. … Yokoyama R. (Jpn. J. Genet. 1992) 3 4 23
  2. Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. (PMID: 11207350) Hines L.M. … Hunter D.J. (N. Engl. J. Med. 2001) 3 23 48
  3. Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx. (PMID: 11303599) Sturgis E.M. … Wei Q. (Cancer Epidemiol. Biomarkers Prev. 2001) 3 23 48
  4. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. (PMID: 11045794) Hines L.M. … Hunter D.J. (Cancer Epidemiol. Biomarkers Prev. 2000) 3 23 48
  5. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. (PMID: 11051375) Chao Y.C. … Chu H.C. (Am. J. Gastroenterol. 2000) 3 23 48

Products for ADH1C Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADH1C
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ADH1C
  • Block miRNA regulation of ADH1C using miScript Target Protectors

Sources for ADH1C Gene

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