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ADH1C Gene

protein-coding   GIFtS: 59
GCID: GC04M100257

Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide


(Previous symbol: ADH3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide1 2     Alcohol Dehydrogenase 3 (Class I), Gamma Polypeptide2
ADH31 2 3 5     Aldehyde Reductase2
EC 1.1.1.13 8     Alcohol Dehydrogenase Subunit Gamma3
ADH, Gamma Subunit2     EC 1.1.18
Alcohol Dehydrogenase 1C2     

External Ids:    HGNC: 2511   Entrez Gene: 1262   Ensembl: ENSG000002481447   OMIM: 1037305   UniProtKB: P003263   

Export aliases for ADH1C gene to outside databases

Previous GC identifers: GC04M100504 GC04M100386 GC04M100452 GC04M100457 GC04M100614 GC04M095995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADH1C Gene:
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase
family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other
aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting
of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol
oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are
tandemly organized in a genomic segment as a gene cluster. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADH1C Gene:
ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide) is a protein-coding gene. Diseases associated with ADH1C include alcoholic liver cirrhosis, and liver cirrhosis. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH1C Gene

PharmGKB "VIP" summary for ADH1C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH1C gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   CUTL1   POU2F2   FOXC1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADH1C promoter sequence
   Search Chromatin IP Primers for ADH1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100257:  view genomic region     (about GC identifiers)

Start:
100,257,649 bp from pter      End:
100,274,184 bp from pter
Size:
16,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 1C  
Size: 375 amino acids; 39868 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
Caution: The reference genome assembly, GRCh37, describes a non-functional copy of that gene with a stop codon at
position 78. However, this premature stop codon is not present in available mRNAs
3 PDB 3D structures from and Proteopedia for ADH1C:
1DDA (3D)        1HT0 (3D)        1U3W (3D)    
Secondary accessions: Q4PJ18 Q5WRV0 Q6LBW4 Q6NWV0 Q6NZA7

Explore the universe of human proteins at neXtProt for ADH1C: NX_P00326

Explore proteomics data for ADH1C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH1C (P00326) (see all 32)
     FSQYTVV  EVAPPKA  CLIGCGF  VPKLVAD 


    See ADH1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000660.1  
    ENSEMBL proteins: 
     ENSP00000426083  
    Reactome Protein details: P00326

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P00326

    ProtoNet protein and cluster: P00326

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family


    ADH1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH1G_HUMAN, P00326
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity IDA6391957
    GO:0008270zinc ion binding IEA--
         
    ADH1C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADH1C:
     Decreased viability with carbo 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adh1):
     growth/size/body  homeostasis/metabolism  mortality/aging 

    ADH1C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADH1C: Adh1tm1Gdu Adh1tm2Gdu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADH1C
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADH1C:
    hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidADH1C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADH1C
    Predesigned siRNA for gene silencing in human, mouse, rat ADH1C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ADH1C (NM_000669)
    Sino Biological Human cDNA Clone for ADH1C
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH1C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADH1G_HUMAN, P00326: Cytoplasm

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    ADH1C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADH1C About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    4Cyclophosphamide Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.00
    5Biological oxidations
    Biological oxidations0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADH1C
        Fatty Acid Omega Oxidation


    1 Reactome Pathway for ADH1C
        Ethanol oxidation

    3 PharmGKB Pathways for ADH1C
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH1C) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450


    ADH1C for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH1C: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADH1C

    1 Interacting protein for ADH1C (P003263) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    ADH1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADH1C (ADH1G)

    Selected HMDB Compounds for ADH1C (see all 17)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Selected DrugBank Compounds for ADH1C (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EthanolAbsolute Alcohol (see all 34)64-17-5targetagonist18688716 21329681 21166830 19618839
    Fomepizole4-methylpyrazole (see all 4)7554-65-6targetinhibitor16946442 16871118 19458366 11391066
    (R)-N-(1-Methyl-Hexyl)-Formamide-- --target--17139284 17016423 10592235
    2,3,4,5,6-Pentafluorobenzyl Alcohol-- 440-60-8target--17139284 17016423 10592235
    2,3-Difluorobenzyl Alcohol-- --target--17139284 17016423 10592235
    2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene-- --target--17139284 17016423 10592235
    2-Ethoxyethanol-- 110-80-5target--17139284 17016423 10592235
    4-Iodopyrazole-- 3469-69-0target--17139284 17016423 10592235
    5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide-- --target--17139284 17016423 10592235
    Cpad-- --target--17139284 17016423 10592235

    7 Novoseek inferred chemical compound relationships for ADH1C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetaldehyde 80.9 11 11700261 (2), 19120062 (1), 16930209 (1), 7943668 (1) (see all 8)
    rsai 72.3 3 10925369 (1), 15318112 (1), 9731720 (1)
    ethanol 62.5 18 15602753 (2), 20101753 (2), 11700261 (2), 19120062 (1) (see all 12)
    formaldehyde 49.7 28 19460944 (3), 19963048 (2), 19011746 (2), 11387027 (1) (see all 8)
    p002 21 1 11207350 (1)
    vitamin a 9.75 1 15602753 (1)
    oligonucleotide 0 1 9063814 (1)



    ADH1C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADH1C gene: 
    NM_000669.4  

    Unigene Cluster for ADH1C:

    Alcohol dehydrogenase 1C (class I), gamma polypeptide
    Hs.654537  [show with all ESTs]
    Unigene Representative Sequence: NM_000669
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515683(uc021xqi.1) ENST00000510055 ENST00000511397 ENST00000505942


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    1 qRT-PCR Assays for microRNA that regulate ADH1C:
    hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidADH1C 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ADH1C
      QuantiFast Probe-based Assays in human, mouse, rat ADH1C

    Additional mRNA sequence: 

    BC062476.1 BC066227.1 BC066228.1 BC067419.1 BC067420.1 BC067421.1 BC067422.1 BC074771.2 
    BC074786.2 M12272.1 X04299.1 X04350.1 

    13 DOTS entries:

    DT.100030344  DT.95158774  DT.101985268  DT.415876  DT.100798841  DT.101985267  DT.121224284  DT.100798849 
    DT.91692319  DT.121224280  DT.100798839  DT.121224262  DT.95158779 

    Selected AceView cDNA sequences (see all 475):

    AA416884 CB139103 BC074786 M12271 BG564896 BM856511 CB138242 CB137629 
    D00137 CB160680 CD014149 BI832910 CB138229 CB154296 BG149939 X04350 
    CD519469 C00945 BU675602 BI758997 BG546605 AU076586 CB157572 CD014078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADH1C expression in normal human tissues (normalized intensities)      ADH1C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTGGAGCA
    ADH1C Expression
    About this image


    ADH1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
             Mature follicles
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    ADH1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654537
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH1C: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADH1C gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adh11 , 5 alcohol dehydrogenase 1 (class I)1, 5 82.22(n)1
    85.07(a)1
      3 (64.16 cM)5
    115221  NM_007409.21  NP_031435.11 
     1382609915 
    chicken
    (Gallus gallus)
    Aves ADH1C1 alcohol dehydrogenase 1C (class I), gamma polypeptide 70.4(n)
    74.13(a)
      771920  XM_001234262.3  XP_001234263.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    Uncharacterized protein
    (see all 7)
    74(a)
    72(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343323.1(1237604-1253112)
    GL343323.1(1263142-1274870)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adh1c1 alcohol dehydrogenase 1C (class I), gamma polypeptide 66.31(n)
    65.68(a)
      594969  NM_001030410.1  NP_001025581.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:635686
    zgc:779386
    (see all 4)
    zgc:77938
    (see all 4)
    56(a)
    56(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(37113161-37120779) ENSDARG00000087262
    14(37121611-37132341) ENSDARG00000088366
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    52(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    50(a)
    32(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFA16
    Bifunctional enzyme containing both alcohol dehydr...
    45(a)
    1 → many
    IV(159604-160764) YDL168W
    rice
    (Oryza sativa)
    Liliopsida Os.125912 O. sativa mRNA for alcohol dehydrogenase 1 74.27(n)    AK073964.1 


    ENSEMBL Gene Tree for ADH1C (if available)
    TreeFam Gene Tree for ADH1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADH1C gene
    ADH62  ADH42  ADH1A2  ADH1B2  ADH52  ADH72  
    6 SIMAP similar genes for ADH1C using alignment to 1 protein entry:     ADH1G_HUMAN:
    ADH1B    ADH1A    ADH7    ADH5    ADH4    ADH6

    ADH1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADH1G_HUMAN, P00326: Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has
    Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate


    Selected SNPs for ADH1C (see all 509)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6981,2,,4
    C,F,Hother1100062596(-) CAAATA/G/TTTTTA 2 I V mis128MN NS EA NA WA 3440
    rs16934821,2,,4
    C,F,Hother1100065771(+) CAAGCC/TGACCG 2 Q R mis119Minor allele frequency- T:0.22MN NS EA NA 1426
    rs2834131,2
    C,F,Hother1100069996(-) GTGTTG/TGAGAA 2 G * stg135Minor allele frequency- T:0.02NS EA NA MN WA CSA EU 3968
    rs665024321,2
    C--95998419(+) GACAA-/CGCC  
            
    CCCCC
    1 -- int10--------
    rs170288601,2
    C,F,H--100059020(+) GAACCT/AAAGTT 1 -- ds500118Minor allele frequency- A:0.04NA NS EA WA 2144
    rs1483273201,2
    --100059027(+) AGTTTA/GTCACA 1 -- ds50010--------
    rs16620321,2
    H--100059084(+) ACTGTA/GAACAA 1 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1121068091,2
    F--100059197(+) TCTTCA/CCTTAT 1 -- ds50012Minor allele frequency- C:0.06CSA WA 120
    rs31140461,2
    C,F,O,A,H--100059242(+) TTACCC/TTAGGG 1 -- ds500132Minor allele frequency- T:0.06NA NS EA WA CSA 2354
    rs344369921,2
    C,F--100059332(-) CACATG/ACTGGG 1 -- ds50016Minor allele frequency- A:0.02NS EA 304

    HapMap Linkage Disequilibrium report for ADH1C (100257649 - 100274184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ADH1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659036CNV Deletion23128226
    nsv528518CNV Loss19592680
    nsv293592CNV Loss16902084
    nsv879656CNV Gain21882294
    nsv879659CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADH1C
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ADH1C
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103730   
    OMIM disorders: 103780  168600  
    Selected diseases for ADH1C (see all 43):    About MalaCards
    alcoholic liver cirrhosis    liver cirrhosis    alcohol dependence, protection against    parkinson's disease
    lrrk2-related parkinson disease    alcohol abuse    pharyngitis    alcohol dependence
    oral cancer    squamous cell carcinoma of the head and neck    drug dependence    coronary heart disease
    acute pancreatitis    stomach cancer    liver disease    gastric adenocarcinoma
    esophageal cancer    esophagitis    oral squamous cell carcinoma    laryngitis


    ADH1C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADH1C gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 77.2 31 15519646 (3), 8773821 (3), 12710951 (2), 15902904 (2) (see all 20)
    pharyngeal cancer 69.1 3 9637146 (1), 10925369 (1), 9390539 (1)
    pancreatitis alcoholic 63 3 8985275 (1), 15220553 (1), 8986224 (1)
    alcoholic cirrhosis 58.5 5 1592339 (2), 15220553 (1), 11748356 (1), 11966948 (1)
    liver diseases alcoholic 57.5 5 15519646 (3), 9731720 (2)
    chronic pancreatitis 48.5 5 16239350 (1), 17454860 (1), 18773092 (1), 11966948 (1) (see all 5)
    pancreatitis 43.1 1 8985275 (1)
    oral cancer 41.7 2 11802217 (1)
    oropharyngeal cancer 41 1 9050916 (1)
    cirrhosis 40.7 7 8985275 (1), 17454860 (1), 1592339 (1), 15519646 (1) (see all 5)

    Genetic Association Database (GAD): ADH1C
    Human Genome Epidemiology (HuGE) Navigator: ADH1C (148 documents)

    Export disorders for ADH1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADH1C gene, integrated from 10 sources (see all 287):
    (articles sorted by number of sources associating them with ADH1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)1, 4, 7 Nishimura F.T....Saijoh K. (amp 2009)
    2. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. (PubMed id 11045794)1, 4, 9 Hines L.M....Hunter D.J. (amp 2000)
    3. Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancer. (PubMed id 11752857)1, 4, 9 van Dijk B....Kiemeney L.A. (Eur. Urol. 2001)
    4. Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. (PubMed id 11207350)1, 4, 9 Hines L.M....Hunter D.J. (N. Engl. J. Med. 2001)
    5. Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes. (PubMed id 11700261)1, 4, 9 Schwartz S.M....Chen C. (amp 2001)
    6. Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (PubMed id 17285601)1, 4, 9 Matsuo K....Tajima K. (Hum. Mutat. 2007)
    7. Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study. (PubMed id 15910847)1, 4, 9 Younis J....Talmud P.J. (Atherosclerosis 2005)
    8. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. (PubMed id 16051248)1, 4, 9 Hines L.M....Rimm E.B. (Atherosclerosis 2005)
    9. Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers. (PubMed id 14732773)1, 4, 9 Nishimoto I.N....Kowalski L.P. (amp 2004)
    10. Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)1, 4, 9 Vidal F....Richart C. (J. Hepatol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126 HGNC: 251 AceView: ADH1AandADH1BandADH1C Ensembl:ENSG00000248144 euGenes: HUgn126
    ECgene: ADH1C Kegg: 126 H-InvDB: ADH1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADH1C Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh1c/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADH1C gene:
    Search GeneIP for patents involving ADH1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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