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ADH1C Gene

protein-coding GIFtS: 65

GC04M100457

alcohol dehydrogenase 1C (class I), gamma polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADH3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADH3 ^², ³, ⁵
EC 1.1.1.1 ^³

Descriptions
ADH, gamma subunit ^²
Alcohol dehydrogenase subunit gamma ^³
alcohol dehydrogenase 1C (class I), gamma polypeptide ^²
alcohol dehydrogenase 1C, gamma polypeptide ^²
alcohol dehydrogenase 3 (class I), gamma polypeptide ^²
aldehyde reductase ^²

External Ids
HGNC: 251¹
Entrez Gene: 126²
UniProtKB: P00326³
Ensembl: ENSG00000187758⁷

Search outside databases for aliases for ADH1C gene

Previous GC identifers: GC04M100504 GC04M100386 GC04M100452 GC04M100614

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADH1C:

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol

dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates,

including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation

products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha,

beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in

ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in

a genomic segment as a gene cluster. [provided by RefSeq]

Gene Wiki entry for ADH1C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADH1C gene

Entrez Gene cytogenetic band: 4q21-q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100457: (about GC identifiers)

Start:	100,476,672 bp from pter
End:	100,492,940 bp from pter
Size:	16,269 bases
Orientation:	minus strand

1 alternative location:

Chr4- 100,416,547-100,431,165

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326 (See protein sequence)

Recommended Name: Alcohol dehydrogenase 1C

Size: 375 amino acids; 39868 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha,

beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to

class-V: ADH6

PDB structures from and Proteopedia :

1DDA (3D)

1HT0 (3D)

1U3W (3D)

Secondary accessions: Q4PJ18 Q5WRV0 Q6LBW4 Q6NWV0 Q6NZA7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000660.1

ENSEMBL proteins:

ENSP00000209668

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADH1C, pan ADH)
	Human Recombinant Proteins from Abnova (ADH1C)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--

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Antibodies for ADH1C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADH1C
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADH1C, pan ADH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADH1C)
	Novus Biologicals Antibodies for ADH1C

Assays for ADH1C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P00326

ProtoNet protein and cluster: P00326

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH1C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000669

Applied Biosystems Silencer® siRNAs for ADH1C

Sigma-Aldrich siRNA and siRNA Panels for ADH1C

Sigma-Aldrich shRNA for ADH1C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADH1C
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000669
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000669
untagged cDNA clones in CMV expression vector (see all 2): NM_000669

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000669

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Number (IUBMB): EC 1.1.1.1

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adh1):

growth/size

homeostasis/metabolism

life span-post-weaning/aging

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004024	alcohol dehydrogenase activity, zinc-dependent	NAS	2935875 6391921
GO:0005488	binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ADH1C (Your Favorite Gene powered by Ingenuity) (see all 6 )

Glycerolipid Metabolism
Glycolysis/Gluconeogenesis
Metabolism of Xenobiotics by Cytochrome P450
Fatty Acid Metabolism
Bile Acid Biosynthesis

GeneDecks ADH1C for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADH1C

5/37 Interacting proteins for ADH1C (ENSP00000209668³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH2	ENSP00000261733³	STRING (score=.993)
ADHFE1	ENSP00000276576³	STRING (score=.992)
ALDH3A1	ENSP00000334590³	STRING (score=.969)
AVP	ENSP00000369647³	STRING (score=.955)
ALDH1A3	ENSP00000332256³	STRING (score=.952)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006066	cellular alcohol metabolic process	NAS	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADH1C:

Inhibitor

Browse Tocris compounds for ADH1C
4 Novoseek chemical compound relationships for ADH1C gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rsai	73.30	3	10925369 (1), 15318112 (1), 9731720 (1)
ethanol	62.78	16	15602753 (2), 11700261 (2), 19120062 (1), 17204375 (1) (see all 11)
p002	21.73	1	11207350 (1)
oligonucleotide	0.00	1	9063814 (1)

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2 PharmGKB drug compound relationships for ADH1C gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
ethanol	PD GN	9731720
xenobiotics	FA GN	12367788

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH1C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000669

Sigma-Aldrich siRNA and siRNA Panels for ADH1C

Sigma-Aldrich shRNA for ADH1C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000669

REFSEQ mRNAs for ADH1C gene:

NM_000669.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000669

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000669
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000669
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000669

Additional cDNA sequence:

BC062476.1 BC066227.1 BC066228.1 BC067419.1 BC067420.1 BC067421.1 BC067422.1 BC074771.2

BC074786.2 M12272.1 X04299.1 X04350.1

13 DOTS entries:

DT.100030344 DT.95158774 DT.101985268 DT.415876 DT.100798841 DT.101985267 DT.121224284 DT.100798849

DT.91692319 DT.121224280 DT.100798839 DT.121224262 DT.95158779

24/475 AceView cDNA sequences (see all 475 ):

CB138477 CD172162 NM_000667 AA416884 CB162202 CD014078 AI275907 BM994680

BG149939 X04350 BP381861 BG564896 AU122403 BG546605 AA634614 CB147187

BQ786902 CB266463 M12963 CB148959 CB157572 BP381206 CB141250 AI262943

highest scoring ESTs for ADH1C:

M12272 BC062476 BC066227 BC066228 BC067419 BC067420 BC067421 BC067422 CB114902 CB114919

Unigene Cluster for ADH1C:

Alcohol dehydrogenase 1C (class I), gamma polypeptide

Hs.654537 [show with all ESTs]

Unigene Representative Sequence: NM_000669

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH1C

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c
SP1:													-				-		-		-		-		-
SP2:															-
SP3:													-
SP4:

About this scheme

ECgene alternative splicing isoforms for ADH1C

1 Ensembl transcript including schematic representation:

ENST00000209668

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADH1C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADH1C

¹ / ² / ³

4 probe-sets matching ADH1C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36247_f_at²^{, 3}	U95-A	3	1.00	0.64	0.99	0.86	M12272	1.00	0.87	0.94	1
34637_f_at²^{, 3}	U95-A	3	1.00	0.33	0.98	1.15	M12963	0.60	0.33	0.49	2
206262_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000669	0.60	0.78	0.69	1
206262_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADH1C for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATCTGGAGCA

SOURCE GeneReport for Unigene cluster: Hs.654537
Expression variation in blood from EXPOLDB for ADH1C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADH1C gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADH1C¹	--	alcohol dehydrogenase 1C (class I), gamma polypeptide	85.96(n) 86.67(a)	478489 XM_535667.2 XP_535667.2
chimpanzee (Pan troglodytes)	ADH1C¹	--	alcohol dehydrogenase 1C (class I), gamma polypeptide	99.38(n) 99.47(a)	744176 XM_001167058.1 XP_001167058.1
cow (Bos taurus)	ADH1C¹	--	alcohol dehydrogenase 1C (class I), gamma polypeptide	85.51(n) 84.53(a)	509744 XM_586772.3 XP_586772.3
rat (Rattus norvegicus)	Adh1¹	--	alcohol dehydrogenase 1 (class I)	81.49(n) 82.76(a)	24172 XM_001053019.1 XP_001053019.1
mouse (Mus musculus)	Adh1^{1, 5}	3 (71.20 cM)⁵	alcohol dehydrogenase 1 (class I)^{1, 5}	82.22(n)¹ 85.07(a)¹	11522¹ NM_007409.2¹ NP_031435.1¹ AI194826⁵ AI850278⁵ (see all 30)

About this table Species with no ortholog for ADH1C

ENSEMBL Gene Tree for ADH1C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADH1C gene

ADH4² ADH1B² ADH5² ADH7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Polymorphism: Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or

gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2

with a slow rate

10/262 NCBI SNPs in ADH1C are shown (see all 262 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 93)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3114046^1,2	A,C,F,H,O	100476455(+)	`TTACCC/TTAGGG`	1	--	ng5¹		12	NA NS EU EA WA	680
	rs2298753^1,2	C,F,H,O	100476930(+)	`TATTGT/CTTCAA`	1	--	ut3¹		21	EA NA EU WA NS	2338
	rs1789924^1,2	C,F,H,O	100493309(+)	`AGTTAC/TGAAGG`	1	--	ng3¹		13	NA MN EA EU WA	1276
	rs1693482^1,2	C,F,H	100482988(+)	`CAAGCC/TGACCG`	1	R/Q	mis¹		15	MN CSAM EA NS EU WA NA	1066
	rs17028860^1,2	C,F,H	100476233(+)	`GAACCT/AAAGTT`	1	--	ng5¹		11	NA EU EA WA	968
	rs17586163^1,2	C,F,H	100493594(+)	`GGTTAT/CGACAC`	1	--	ng3¹		7	NA EU EA WA	562
	rs11499823^1,2	C,F,H	100493772(-)	`ACAACT/CCTGGA`	1	--	ng3¹		9	EU EA WA NS	594
--	rs1693468^1,2	C,F	100494838(+)	`CCTATC/GAAAAA`	1	--	ng3¹		5	NS	190
	rs4147541^1,2	C,F	100493180(-)	`AGGAAG/CTTGAG`	1	--	ng3¹		10	NA MN EA NS	658
--	rs1789925^1,2	C,F	100494768(+)	`ACCATT/CTTGTT`	1	--	ng3¹		5	NS	190

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HapMap Linkage Disequilibrium images for ADH1C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 103730 disorders: 168600

10/28 Novoseek disease relationships for ADH1C gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	77.42	31	15519646 (3), 8773821 (3), 12710951 (2), 15902904 (2) (see all 20)
pharyngeal cancer	70.14	3	9637146 (1), 10925369 (1), 9390539 (1)
pancreatitis alcoholic	64.04	3	8985275 (1), 15220553 (1), 8986224 (1)
alcoholic cirrhosis	59.81	5	1592339 (2), 15220553 (1), 11748356 (1), 11966948 (1)
liver diseases alcoholic	58.88	5	15519646 (3), 9731720 (2)
chronic pancreatitis	49.97	5	16239350 (1), 17454860 (1), 18773092 (1), 11966948 (1) (see all 5)
oropharyngeal cancer	43.92	1	9050916 (1)
oral cancer	43.81	2	11802217 (1)
cirrhosis	42.50	7	8985275 (1), 17454860 (1), 1592339 (1), 15519646 (1) (see all 5)
pancreatitis	41.54	1	8985275 (1)

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2 PharmGKB disease relationships for ADH1C gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Liver Diseases, Alcoholic	PD GN	9731720
Lung Neoplasms	FA GN	12367788

About this table

Human Gene Mutation Database: ADH1C
Genetic Association Database: ADH1C
Human Genome Epidemiology Navigator: ADH1C (104 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/208 PubMed articles for ADH1C gene (see all 208 ):

A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. (PubMed id 11045794)^{1, 3, 6} Hines L.M....Hunter D.J. (2000)
Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancer. (PubMed id 11752857)^{1, 3, 6} van Dijk B....Kiemeney L.A. (2001)
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. (PubMed id 16051248)^{1, 3, 6} Hines L.M....Rimm E.B. (2005)
Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)^{1, 3, 6} Vidal F....Richart C. (2004)
Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers. (PubMed id 14732773)^{1, 3, 6} Nishimoto I.N....Kowalski L.P. (2004)
Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck. (PubMed id 15767341)^{1, 3, 6} Wang D....Haugen T.H. (2005)
Alcohol dehydrogenase 3, glutathione S-transferase M1 and T1 polymorphisms, alcohol consumption and hepatocellular carcinoma (Italy). (PubMed id 16132793)^{1, 3, 6} Covolo L....Donato F. (2005)
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. (PubMed id 16039674)^{1, 3, 6} van der Logt E.M....Peters W.H. (2006)
Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. (PubMed id 15863807)^{1, 3, 6} Chai Y.G....Choi I.G. (2005)
ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. (PubMed id 15318112)^{1, 3, 6} Konishi T....Wan Y.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 126	HGNC: 251	AceView: ADH1AandADH1BandADH1C	Ensembl:ENSG00000187758	euGenes: HUgn126
ECgene: ADH1C	H-InvDB: ADH1C

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh1c/

Licensable Technologies for ADH1C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADH1C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADH1C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADH1C		Antibodies for ADH1C
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADH1C		Small molecules for ADH1C
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADH1C)
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	Recombinant Proteins (ADH1C, pan ADH)
	Antibodies (ADH1C, pan ADH)

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Antibodies for ADH1C

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ADH1C Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ADH1C

Summaries
for ADH1C

Genomic Location
for ADH1C

Proteins
for ADH1C

Protein Domains/
Families
for ADH1C

Gene Function
for ADH1C

Pathways & Interactions
for ADH1C

Drugs & Compounds
for ADH1C

Transcripts
for ADH1C

Expression
for ADH1C

Orthologs
for ADH1C

Paralogs
for ADH1C

SNPs/Variants
for ADH1C

Disorders & Mutations
for ADH1C

Medical News
for ADH1C

Publications
for ADH1C

Search for ADH1C

Genome Databases showing ADH1C

Other Databases showing ADH1C

Specialized Databases showing ADH1C

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for ADH1C

Services
for ADH1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADH1C Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ADH1C

Summariesfor ADH1C

Genomic Locationfor ADH1C

Proteinsfor ADH1C

Protein Domains/Familiesfor ADH1C

Gene Functionfor ADH1C

Pathways & Interactionsfor ADH1C

Drugs & Compoundsfor ADH1C

Transcriptsfor ADH1C

Expression for ADH1C

Orthologsfor ADH1C

Paralogsfor ADH1C

SNPs/Variantsfor ADH1C

Disorders & Mutationsfor ADH1C

Medical Newsfor ADH1C

Publicationsfor ADH1C

Search for ADH1C

Genome Databases showing ADH1C

Other Databases showing ADH1C

Specialized Databases showing ADH1C

Licensable Technologiesfor ADH1C

Servicesfor ADH1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADH1C

Summaries
for ADH1C

Genomic Location
for ADH1C

Proteins
for ADH1C

Protein Domains/
Families
for ADH1C

Gene Function
for ADH1C

Pathways & Interactions
for ADH1C

Drugs & Compounds
for ADH1C

Transcripts
for ADH1C

Expression
for ADH1C

Orthologs
for ADH1C

Paralogs
for ADH1C

SNPs/Variants
for ADH1C

Disorders & Mutations
for ADH1C

Medical News
for ADH1C

Publications
for ADH1C

Licensable Technologies
for ADH1C

Services
for ADH1C