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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADH1C Gene

protein-coding GIFtS: 59
GCID: GC04M100257

alcohol dehydrogenase 1C (class I), gamma polypeptide

(Previous symbol: ADH3)

Explore 44 diseases affiliated with
ADH1C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide¹ ²		Alcohol Dehydrogenase 1C²
ADH3¹ ² ³ ⁵		Alcohol Dehydrogenase 3 (Class I), Gamma Polypeptide²
Alcohol Dehydrogenase Subunit Gamma² ³		Aldehyde Reductase²
EC 1.1.1.1³ ⁸		EC 1.1.1⁸
ADH, Gamma Subunit²

External Ids:	HGNC: 251¹	Entrez Gene: 126²	Ensembl: ENSG00000248144⁷	OMIM: 103730⁵	UniProtKB: P00326³

Export aliases for ADH1C gene to outside databases

Previous GC identifers: GC04M100504 GC04M100386 GC04M100452 GC04M100457 GC04M100614 GC04M095995

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADH1C:

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family.

Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic

alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo-

and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major

role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic

segment as a gene cluster. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ADH1C

PharmGKB "VIP" summary for ADH1C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADH1C gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 CUTL1 POU2F2 FOXC1 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADH1C promoter sequence

Search SABiosciences Chromatin IP Primers for ADH1C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH1C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1C gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100257: view genomic region (about GC identifiers)

Start:	100,257,649 bp from pter	End:	100,274,184 bp from pter
Size:	16,536 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326 (See protein sequence)

Recommended Name: Alcohol dehydrogenase 1C

Size: 375 amino acids; 39868 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to

class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

Caution: The reference genome assembly, GRCh37, describes a non-functional copy of that gene with a stop codon at

position 78. However, this premature stop codon is not present in available mRNAs

3 PDB 3D structures from and Proteopedia for ADH1C:

1DDA (3D)

1HT0 (3D)

1U3W (3D)

Secondary accessions: Q4PJ18 Q5WRV0 Q6LBW4 Q6NWV0 Q6NZA7

Explore the universe of human proteins at neXtProt for ADH1C: NX_P00326

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P00326

4/32 DME Specific Peptides for ADH1C (P00326) (see all 32)

FSQYTVV

EVAPPKA

CLIGCGF

VPKLVAD

ADH1C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000660.1

ENSEMBL proteins:

ENSP00000426083

Reactome Protein details: P00326
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for ADH1C
	Uscn Proteins for ADH1C

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ADH1C for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ADH1C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADH1C for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013149 ADH_C

IPR011032 GroES-like

IPR016040 NAD(P)-bd_dom

IPR002328 ADH_Zn_CS

IPR013154 ADH_GroES-like

Graphical View of Domain Structure for InterPro Entry P00326

ProtoNet protein and cluster: P00326

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB): EC 1.1.1.1¹ ² EC 1.1.1²

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ADH1C:
		hsa-miR-1290
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ADH1C

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004022	alcohol dehydrogenase (NAD) activity	IDA	6391957
GO:0008270	zinc ion binding	IEA	--

ADH1C for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ADH1C:

Decreased viability with carbo

Animal Models:
Mouse knock-outs for ADH1C: Adh1^tm1Gdu Adh1^tm2Gdu
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adh1):

growth/size

homeostasis/metabolism

mortality/aging

ADH1C for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ethanol oxidation

	Ethanol oxidation	1.00			Cyclophosphamide Pathway, Pharmacodynamics	0.42
	Fatty Acid Omega Oxidation	0.47

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Tyrosine metabolism

Tyrosine metabolism

1.00

Biological oxidations

Biological oxidations

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ADH1C

Fatty Acid Omega Oxidation

4 Reactome Pathways for ADH1C

	Ethanol oxidation
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

1 PharmGKB Pathway for ADH1C

Cyclophosphamide Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for ADH1C) (see all 7):

	Glycolysis / Gluconeogenesis
	Fatty acid metabolism
	Tyrosine metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450

ADH1C for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADH1C

1 Interacting protein for ADH1C (P00326³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAE	P62258³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006069	ethanol oxidation	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

ADH1C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADH1C for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADH1C

10/17 HMDB Compounds for ADH1C (see all 17) About this table

Compound	Synonyms	CAS #	PubMed Ids
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylglycol	(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)	28822-73-3	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
9-cis-Retinal	9-cis-Retinal (see all 5)	514-85-2	--
Acetaldehyde	acetaldehyde (see all 5)	75-07-0	--
Betaine aldehyde	(Formylmethyl)trimethylammonium (see all 8)	7418-61-3	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--
Glycerol	1,2,3-Trihydroxypropane (see all 22)	56-81-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

10/20 DrugBank Compounds for ADH1C (see all 20) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ethanol	Absolute Alcohol (see all 34)	64-17-5	target	agonist	18688716 21329681 21166830 19618839
Fomepizole	4-methylpyrazole (see all 4)	7554-65-6	target	inhibitor	16946442 16871118 19458366 11391066
(R)-N-(1-Methyl-Hexyl)-Formamide	--	--	target	--	17139284 17016423 10592235
2,3,4,5,6-Pentafluorobenzyl Alcohol	--	440-60-8	target	--	17139284 17016423 10592235
2,3-Difluorobenzyl Alcohol	--	--	target	--	17139284 17016423 10592235
2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene	--	--	target	--	17139284 17016423 10592235
2-Ethoxyethanol	--	110-80-5	target	--	17139284 17016423 10592235
4-Iodopyrazole	--	3469-69-0	target	--	17139284 17016423 10592235
5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide	--	--	target	--	17139284 17016423 10592235
Cpad	--	--	target	--	17139284 17016423 10592235

7 Novoseek chemical compound relationships for ADH1C gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetaldehyde	80.9	11	11700261 (2), 19120062 (1), 16930209 (1), 7943668 (1) (see all 8)
rsai	72.3	3	10925369 (1), 15318112 (1), 9731720 (1)
ethanol	62.5	18	15602753 (2), 20101753 (2), 11700261 (2), 19120062 (1) (see all 12)
formaldehyde	49.7	28	19460944 (3), 19963048 (2), 19011746 (2), 11387027 (1) (see all 8)
p002	21	1	11207350 (1)
vitamin a	9.75	1	15602753 (1)
oligonucleotide	0	1	9063814 (1)

Search CenterWatch for drugs/clinical trials and news about ADH1C / ADH1G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADH1C gene:

NM_000669.3

Unigene Cluster for ADH1C:

Alcohol dehydrogenase 1C (class I), gamma polypeptide

Hs.654537 [show with all ESTs]

Unigene Representative Sequence: NM_000669

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000515683(uc021xqi.1) ENST00000510055 ENST00000511397 ENST00000505942

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		hsa-miR-1290
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Additional cDNA sequence:

BC062476.1 BC066227.1 BC066228.1 BC067419.1 BC067420.1 BC067421.1 BC067422.1 BC074771.2

BC074786.2 M12272.1 X04299.1 X04350.1

13 DOTS entries:

DT.100030344 DT.95158774 DT.101985268 DT.415876 DT.100798841 DT.101985267 DT.121224284 DT.100798849

DT.91692319 DT.121224280 DT.100798839 DT.121224262 DT.95158779

24/475 AceView cDNA sequences (see all 475):

AI275907 BM980353 BI758997 CB135740 AV681652 CB267103 BX099744 D00137

CB138477 BX472538 AA903791 CB148337 BQ786902 BU687891 CB138242 BP381861

CD014078 NM_000667 D58197 AU076586 M12271 BM975207 AU121675 AU122226

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADH1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTGGAGCA

About this image

ADH1C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Ovary

Pancreas

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See ADH1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADH1C

SOURCE GeneReport for Unigene cluster: Hs.654537

SABiosciences Expression via Pathway-Focused PCR Arrays including ADH1C:

Drug Metabolism: Phase I Enzymes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1C gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Adh1^{1 , 5}	alcohol dehydrogenase 1 (class I)^{1, 5}	82.22(n)¹ 85.07(a)¹	3 (64.16 cM)⁵ 11522¹ NM_007409.2¹ NP_031435.1¹ 138260991⁵
chicken (Gallus gallus)	Aves	ADH1C¹	alcohol dehydrogenase 1C (class I), gamma polypeptide	70.6(n) 74.53(a)	771920 XM_001234262.2 XP_001234263.2
rice (Oryza sativa)	Liliopsida	Os.12591²	O. sativa mRNA for alcohol dehydrogenase 1	74.27(n)	AK073964.1

ENSEMBL Gene Tree for ADH1C (if available)
TreeFam Gene Tree for ADH1C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ADH1G_HUMAN, P00326

Polymorphism: Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has

Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs698^1,2	C,F,H,	other	95998537(-)	`CAAATA/G/TTTTTA`	3	I V F	mis¹		28		MN NS EA NA WA	3440
rs1693482^1,2	C,F,H,	other	96001712(+)	`CAAGCC/TGACCG`	2	Q R	mis¹		19		MN NS EA NA	1426
rs17028860^1,2	C,F,H,	--	95994979(+)	`GAACCT/AAAGTT`	1	--	ds500¹		18		NA NS EA WA	2144
rs1662032^1,2	H	--	95995043(+)	`ACTGTA/GAACAA`	1	--	ds500¹		4		NS EA	418
rs112106809^1,2		--	95995156(+)	`TCTTCA/CCTTAT`	1	--	ds500¹		2		CSA WA	120
rs77988166^1,2		--	95995673(+)	`CTGTAC/TTGTTT`	1	--	ut3¹		0	--	--	--	--
rs67420531^1,2	F	--	95995698(+)	`GGTACG/AGATAC`	2	/R /C	mis¹		4		MN WA EA	828
rs7658726^1,2	C,H,	--	95996263(+)	`AGATAC/ACTTGC`	1	--	int¹		4		NS EA	418
rs36019411^1,2	C,F,	--	95996628(-)	`ACTCCG/AAGGTC`	1	--	int¹		7		NS CSA WA	294
rs2851299^1,2	C,F,	--	95997369(+)	`AGGGGC/TGGTGT`	1	--	int¹		3		NA	124

HapMap Linkage Disequilibrium report for ADH1C (100257649 - 100274184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADH1C
1 Indel: 12502
Human Gene Mutation Database (HGMD): ADH1C

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADH1C for disorders           About GeneDecksing

OMIM gene information: 103730
OMIM disorders: 103780  168600
20/44 diseases for ADH1C (see all 44):    About MalaCards

alcoholism alcohol dependence, protection against alcohol dependence alcohol abuse

squamous cell carcinoma coronary heart disease liver cirrhosis alcoholic liver cirrhosis

drug dependence myocardial infarction oral squamous cell carcinoma squamous cell carcinoma of the head and neck

esophageal squamous cell carcinoma parkinson's disease hearing loss liver disease

intrahepatic cholangiocarcinoma laryngeal cancer laryngitis acute pancreatitis

10/28 Novoseek disease relationships for ADH1C gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	77.2	31	15519646 (3), 8773821 (3), 12710951 (2), 15902904 (2) (see all 20)
pharyngeal cancer	69.1	3	9637146 (1), 10925369 (1), 9390539 (1)
pancreatitis alcoholic	63	3	8985275 (1), 15220553 (1), 8986224 (1)
alcoholic cirrhosis	58.5	5	1592339 (2), 15220553 (1), 11748356 (1), 11966948 (1)
liver diseases alcoholic	57.5	5	15519646 (3), 9731720 (2)
chronic pancreatitis	48.5	5	16239350 (1), 17454860 (1), 18773092 (1), 11966948 (1) (see all 5)
pancreatitis	43.1	1	8985275 (1)
oral cancer	41.7	2	11802217 (1)
oropharyngeal cancer	41	1	9050916 (1)
cirrhosis	40.7	7	8985275 (1), 17454860 (1), 1592339 (1), 15519646 (1) (see all 5)

Genetic Association Database (GAD): ADH1C
Human Genome Epidemiology (HuGE) Navigator: ADH1C (148 documents)

Export disorders for ADH1C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADH1C gene, integrated from 9 sources (see all 279):
(articles sorted by number of sources associating them with ADH1C)

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world of online information

A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. (PubMed id 11045794)^{1, 4, 9} Hines L.M....Hunter D.J. (2000)
Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancer. (PubMed id 11752857)^{1, 4, 9} van Dijk B....Kiemeney L.A. (2001)
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. (PubMed id 16051248)^{1, 4, 9} Hines L.M....Rimm E.B. (2005)
Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers. (PubMed id 14732773)^{1, 4, 9} Nishimoto I.N....Kowalski L.P. (2004)
Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)^{1, 4, 9} Vidal F....Richart C. (2004)
Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck. (PubMed id 15767341)^{1, 4, 9} Wang D....Haugen T.H. (2005)
Alcohol dehydrogenase 3, glutathione S-transferase M1 and T1 polymorphisms, alcohol consumption and hepatocellular carcinoma (Italy). (PubMed id 16132793)^{1, 4, 9} Covolo L....Donato F. (2005)
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. (PubMed id 16039674)^{1, 4, 9} van der Logt E.M....Peters W.H. (2006)
Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. (PubMed id 15863807)^{1, 4, 9} Chai Y.G....Choi I.G. (2005)
Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (PubMed id 15654505)^{1, 4, 9} Liu Y....Tsugane S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 126	HGNC: 251	AceView: ADH1AandADH1BandADH1C	Ensembl:ENSG00000248144	euGenes: HUgn126
ECgene: ADH1C	Kegg: 126	H-InvDB: ADH1C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADH1C	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh1c/

Intellectual Property for ADH1C gene
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Patent Information for ADH1C gene:
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GeneCards and IP:
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ADH1C Gene

alcohol dehydrogenase 1C (class I), gamma polypeptide

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ADH1C Gene

alcohol dehydrogenase 1C (class I), gamma polypeptide

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