Aliases for ADH1B Gene
External Ids for ADH1B Gene
Previous HGNC Symbols for ADH1B Gene
Previous GeneCards Identifiers for ADH1B Gene
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ADH1B Gene
ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Alcoholic Liver Cirrhosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Cyclophosphamide Pathway, Pharmacodynamics. GO annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.