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ADH1B Gene

protein-coding GIFtS: 65

GC04M100456

alcohol dehydrogenase 1B (class I), beta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADH2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ADH2 ^², ³, ⁵
DKFZp686C06125 ^²
EC 1.1.1.1 ^³

Descriptions
ADH, beta subunit ^²
Alcohol dehydrogenase subunit beta ^³
alcohol dehydrogenase 1B (class I), beta polypeptide ^²
alcohol dehydrogenase 2 (class I), beta polypeptide ^²
aldehyde reductase ^²
class I alcohol dehydrogenase, beta subunit ^²

External Ids
HGNC: 250¹
Entrez Gene: 125²
UniProtKB: P00325³
Ensembl: ENSG00000196616⁷

Search outside databases for aliases for ADH1B gene

Previous GC identifers: GC04M100473 GC04M100451 GC04M100577

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADH1B:

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this

enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic

alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of

several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for

ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta

and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by

RefSeq]

Gene Wiki entry for ADH1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADH1B gene

Entrez Gene cytogenetic band: 4q21-q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100456: (about GC identifiers)

Start:	100,445,157 bp from pter
End:	100,461,581 bp from pter
Size:	16,425 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325 (See protein sequence)

Recommended Name: Alcohol dehydrogenase 1B

Size: 375 amino acids; 39855 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha,

beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to

class-V: ADH6

PDB structures from and Proteopedia :

1DEH (3D)

1HDX (3D)

1HDY (3D)

1HDZ (3D)

1HSZ (3D)

1HTB (3D)

1U3U (3D)

1U3V (3D)

3HUD (3D)

Secondary accessions: Q13711 Q4ZGI9 Q96KI7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000659.2

ENSEMBL proteins:

ENSP00000378351 ENSP00000306606

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN for ADH1B
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADH1B, pan ADH)
	Human Recombinant Proteins from Abnova (ADH1B)

OriGene Purified Recombinant Human Protein: ADH1B

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for ADH1B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for ADH1B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADH1B, pan ADH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADH1B)
	Novus Biologicals Antibodies for ADH1B

Assays for ADH1B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00325

ProtoNet protein and cluster: P00325

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000668

Applied Biosystems Silencer® siRNAs for ADH1B

Sigma-Aldrich siRNA and siRNA Panels for ADH1B

Sigma-Aldrich shRNA Panels and shRNA for ADH1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADH1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000668
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000668
untagged cDNA clone in CMV expression vector: NM_000668

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000668

UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Number (IUBMB): EC 1.1.1.1

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004022	alcohol dehydrogenase activity	IEA	--
GO:0005488	binding	IEA	--
GO:0008270	zinc ion binding	IDA	9982
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ADH1B (Your Favorite Gene powered by Ingenuity) (see all 6 )

Tyrosine Metabolism
Fatty Acid Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Glycolysis/Gluconeogenesis
Bile Acid Biosynthesis

GeneDecks ADH1B for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADH1B

5/45 Interacting proteins for ADH1B (ENSP00000306606³) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH2	ENSP00000261733³	STRING (score=.996)
ADHFE1	ENSP00000276576³	STRING (score=.992)
CYP2E1	ENSP00000252945³	STRING (score=.987)
ALDH3A1	ENSP00000334590³	STRING (score=.971)
COMT	ENSP00000207636³	STRING (score=.968)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006069	ethanol oxidation	IDA	2398055
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADH1B:

Mixed Agonist/Antagonist Activator Antagonist Agonist Inhibitor Ligand

Browse Tocris compounds for ADH1B
6 Novoseek chemical compound relationships for ADH1B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ethanol	68.78	43	11584144 (3), 8512495 (3), 15564879 (2), 10826103 (2) (see all 23)
rsai	68.51	3	15318112 (1), 7557863 (1), 11696658 (1)
mspi	28.97	1	11696658 (1)
oligonucleotide	5.42	3	8512495 (1), 9063814 (1)
polyacrylamide	0.00	5	12705337 (1), 16135443 (1)
glucose	0.00	4	18216179 (2), 16307179 (2)

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2 PharmGKB drug compound relationships for ADH1B gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
alcohol	PD GN	12244546 12505800
ethanol	PD GN	9194910 9802529

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADH1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADH1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000668

Sigma-Aldrich siRNA and siRNA Panels for ADH1B

Sigma-Aldrich shRNA Panels and shRNA for ADH1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000668

REFSEQ mRNAs for ADH1B gene:

NM_000668.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000668

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000668
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000668
                                 untagged cDNA clone in CMV expression vector: NM_000668

Additional cDNA sequence:

AF153821.1 AK299409.1 AK301018.1 AK303945.1 AK304396.1 AK311712.1 AK316501.1 BC033009.2

D00137.1 M21692.1 M24317.1 X03350.1

24/28 DOTS entries (see all 28 ):

DT.91692319 DT.100798841 DT.100798848 DT.99980497 DT.121224179 DT.100798847 DT.91670613 DT.92469079

DT.121224294 DT.121224163 DT.92469055 DT.95283613 DT.121224238 DT.454964 DT.100798850 DT.92469117

DT.95158780 DT.121224235 DT.100001280 DT.121224120 DT.121224260 DT.415876 DT.91698740 DT.95361176

24/475 AceView cDNA sequences (see all 475 ):

CB148959 CB138477 BM975207 CB120359 CB147446 BC074786 AA634614 BI517854

AU121675 AV681854 CB138240 AA903791 CB148337 BQ786902 C00945 AV709059

D00137 CB138242 AU122403 BC074738 BM856511 CB266463 AU076586 CB154296

highest scoring ESTs for ADH1B:

CD515958 BX472537 BX481224 BX501680 BX647469 AV646555 X03350 AA708155 AU121611 AU121675

Unigene Cluster for ADH1B:

Alcohol dehydrogenase 1B (class I), beta polypeptide

Hs.4 [show with all ESTs]

Unigene Representative Sequence: AF153821

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000394887 ENST00000305046

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADH1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADH1B

¹ / ² / ³

9 probe-sets matching ADH1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35730_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.12	X03350	0.60	0.47	0.54	1
66299_r_at²^{, 3}	U95-C	1	1.00	1.00	0.81	0.62	AA708155	0.40	0.44	0.42	1
34637_f_at²^{, 3}	U95-A	3	1.00	0.33	0.98	1.28	M12963	0.40	0.13	0.30	3
209613_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M21692	0.40	0.33	0.37	2
209612_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M24317	0.40	0.33	0.37	2
209614_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF153821	0.40	0.33	0.37	2
209613_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209612_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209614_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks ADH1B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAAAGATTAT

SOURCE GeneReport for Unigene cluster: Hs.4
Expression variation in blood from EXPOLDB for ADH1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADH1B gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADH1B¹	--	alcohol dehydrogenase 1B (class I), beta polypeptide	99.29(n) 99.47(a)	461396 NM_001034158.1 NP_001029330.1
chicken (Gallus gallus)	ADH1B¹	--	alcohol dehydrogenase 1B (class I), beta polypeptide	67.39(n) 67.48(a)	771920 XM_001234262.1 XP_001234263.1
baker's yeast (Saccharomyces cerevisiae)	ADH1(YOL086C)⁴	15(160594-159548)	Alcohol dehydrogenase, fermentative isozyme active more	--	854068 NP_014555.1
African clawed frog (Xenopus laevis)	MGC68507²	--	hypothetical protein MGC68507	73.24(n)	BC061682.1
rainbow trout (Oncorhynchus mykiss)	BX862123.1²	--	--	74.77(n)	BX862123.1

About this table Species with no ortholog for ADH1B

ENSEMBL Gene Tree for ADH1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADH1B gene

ADH1C² ADH4² ADH5² ADH7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325

Polymorphism: Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2

(ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The

sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is

approximately 75%, whereas it is less than 5% in most Caucasian populations

10/148 NCBI SNPs in ADH1B are shown (see all 148 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1042026^1,2	A,C,F,H,O	100447489(-)	`GGTCCA/GAGAGT`	1	--	ut3¹ ese³		20	MN EA NS EU WA NA	1910
	rs1159918^1,2	A,C,F,H,O	100462032(-)	`TTGGGG/TGTCTG`	1	--	ng3¹		15	EU EA WA NS NA	1156
	rs17033^1,2	C,F,H,O	100447968(-)	`CCTACA/GAGATC`	1	--	ut3¹ ese³		26	MN CSAM EA EU WA NS	2404
	rs1229982^1,2	A,C,F,H	100462955(+)	`TTGCTG/TCTAGT`	1	--	ng3¹		17	EU EA WA NS	1436
	rs1229984^1,2	A,C,F,H	100458342(-)	`CTGTCG/ACACAG`	1	R/H	mis¹		22	MN EU EA WA CSAM NS NA	1874
	rs3811802^1,2	C,F,H	100463244(-)	`AGAAGT/CGAAGC`	1	--	ng3¹ tfbs³		10	EA NS EU WA	2088
	rs2066702^1,2	C,F,H	100448040(-)	`GTATCC/TGTACC`	1	R/C	mis¹ ese³		19	MN CSAM EA NS EU WA NA	1512
--	rs1229981^1,2	C,F	100463172(+)	`ATCCTC/ACCCAA`	1	--	ng3¹		5	NS	180
	rs3811801^1,2	C,F	100463342(-)	`TAGAAT/CTTAGG`	1	--	ng3¹		6	EA NS	1650
--	rs2070898^1,2	C,F	100462320(-)	`TTCATC/TTTCAT`	1	--	ng3¹		5	NS	158

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HapMap Linkage Disequilibrium images for ADH1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 103720 disorders: 103780

10/26 Novoseek disease relationships for ADH1B gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	81.80	62	7625477 (4), 18299763 (3), 15519646 (3), 8773821 (3) (see all 35)
pancreatitis alcoholic	70.56	6	8985275 (1), 15220553 (1), 11117576 (1), 8986224 (1) (see all 5)
alcoholic cirrhosis	63.41	7	15220553 (1), 8845660 (1), 11748356 (1), 11966948 (1) (see all 5)
liver diseases alcoholic	61.42	6	15519646 (3), 8591846 (1), 9194910 (1)
chronic pancreatitis	53.98	6	17454860 (1), 18773092 (1), 11966948 (1), 1937384 (1) (see all 5)
macrocytosis	44.86	1	16759795 (1)
pancreatitis	40.75	2	8985275 (1), 10235286 (1)
genetic susceptibility	39.42	1	16270392 (1)
fetal alcohol syndrome	38.87	2	17618743 (1), 12461493 (1)
cirrhosis	37.76	6	8985275 (1), 12915519 (1), 17454860 (1), 15519646 (1) (see all 5)

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2 PharmGKB disease relationships for ADH1B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Alcoholism	FA GN	15564879
Liver Diseases, Alcoholic	PD GN	9194910

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Human Gene Mutation Database: ADH1B
Genetic Association Database: ADH1B
Human Genome Epidemiology Navigator: ADH1B (143 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/294 PubMed articles for ADH1B gene (see all 294 ):

Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. (PubMed id 12505800)^{1, 3, 7} Wall T.L....Ehlers C.L. (2003)
Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)^{1, 3, 6} Vidal F....Richart C. (2004)
[Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population.] (PubMed id 15842823)^{1, 3, 6} Cao X.R. and Wu D.S. (2005)
Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study. (PubMed id 15886702)^{1, 3, 6} Lilla C....Chang-Claude J. (2005)
[Studies of genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang China] (PubMed id 16135443)^{1, 3, 6} Zhang Z.M....Shen F.M. (2002)
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes and male alcohol use disorders in Khon Kaen, north-east Thailand. (PubMed id 12519453)^{1, 3, 6} Osaka R....Fukuda K. (2003)
Alcohol and ADH2 in Israel: Ashkenazis, Sephardics, and recent Russian immigrants. (PubMed id 12153842)^{1, 3, 6} Hasin D....Li T.K. (2002)
Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. (PubMed id 15084894)^{1, 3, 6} Huang S.Y....Lu R.B. (2004)
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. (PubMed id 15534263)^{1, 3, 6} Suzuki Y....Ohta S. (2004)
A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. (PubMed id 14768474)^{1, 3, 6} Sakata R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 125	HGNC: 250	AceView: ADH1AandADH1BandADH1C	Ensembl:ENSG00000196616	euGenes: HUgn125
ECgene: ADH1B	H-InvDB: ADH1B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADH1B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh1b/

Licensable Technologies for ADH1B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADH1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADH1B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADH1B		Antibodies for ADH1B
	Explore super-pooled esiRNAs		Proteins for ADH1B
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	Recombinant Proteins (ADH1B)
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Antibodies for ADH1B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADH1B Gene at Home site.
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ADH1B Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ADH1B

Summaries
for ADH1B

Genomic Location
for ADH1B

Proteins
for ADH1B

Protein Domains/
Families
for ADH1B

Gene Function
for ADH1B

Pathways & Interactions
for ADH1B

Drugs & Compounds
for ADH1B

Transcripts
for ADH1B

Expression
for ADH1B

Orthologs
for ADH1B

Paralogs
for ADH1B

SNPs/Variants
for ADH1B

Disorders & Mutations
for ADH1B

Medical News
for ADH1B

Publications
for ADH1B

Search for ADH1B

Genome Databases showing ADH1B

Other Databases showing ADH1B

Specialized Databases showing ADH1B

Licensable Technologies
for ADH1B

Services
for ADH1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADH1B Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ADH1B

Summariesfor ADH1B

Genomic Locationfor ADH1B

Proteinsfor ADH1B

Protein Domains/Familiesfor ADH1B

Gene Functionfor ADH1B

Pathways & Interactionsfor ADH1B

Drugs & Compoundsfor ADH1B

Transcriptsfor ADH1B

Expression for ADH1B

Orthologsfor ADH1B

Paralogsfor ADH1B

SNPs/Variantsfor ADH1B

Disorders & Mutationsfor ADH1B

Medical Newsfor ADH1B

Publicationsfor ADH1B

Search for ADH1B

Genome Databases showing ADH1B

Other Databases showing ADH1B

Specialized Databases showing ADH1B

Licensable Technologiesfor ADH1B

Servicesfor ADH1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADH1B

Summaries
for ADH1B

Genomic Location
for ADH1B

Proteins
for ADH1B

Protein Domains/
Families
for ADH1B

Gene Function
for ADH1B

Pathways & Interactions
for ADH1B

Drugs & Compounds
for ADH1B

Transcripts
for ADH1B

Expression
for ADH1B

Orthologs
for ADH1B

Paralogs
for ADH1B

SNPs/Variants
for ADH1B

Disorders & Mutations
for ADH1B

Medical News
for ADH1B

Publications
for ADH1B

Licensable Technologies
for ADH1B

Services
for ADH1B