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ADH1B Gene

protein-coding   GIFtS: 62
GCID: GC04M100226

Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide


(Previous symbol: ADH2)
  See ADH1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide1 2     Alcohol Dehydrogenase 1B2
ADH21 2 3 5     Alcohol Dehydrogenase 2 (Class I), Beta Polypeptide2
Alcohol Dehydrogenase Subunit Beta2 3     Aldehyde Reductase2
EC 1.1.1.13 8     Epididymis Secretory Protein Li 1172
HEL-S-1172     EC 1.1.18
ADH, Beta Subunit2     

External Ids:    HGNC: 2501   Entrez Gene: 1252   Ensembl: ENSG000001966167   OMIM: 1037205   UniProtKB: P003253   

Export aliases for ADH1B gene to outside databases

Previous GC identifers: GC04M100473 GC04M100451 GC04M100456 GC04M100577 GC04M095965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADH1B Gene:
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family
metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids,
and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha,
beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol
catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a
gene cluster. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2013)

GeneCards Summary for ADH1B Gene:
ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide) is a protein-coding gene. Diseases associated with ADH1B include alcohol dependence, protection against, and aerodigestive tract cancer, squamous cell, alcohol-related, protection against. GO annotations related to this gene include alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH1B Gene

PharmGKB "VIP" summary for ADH1B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH1B gene promoter:
         AREB6   GR   LHX3b/Lhx3b   CP2   p53   LHX3a/Lhx3a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADH1B promoter sequence
   Search Chromatin IP Primers for ADH1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100226:  view genomic region     (about GC identifiers)

Start:
100,226,121 bp from pter      End:
100,242,572 bp from pter
Size:
16,452 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 1B  
Size: 375 amino acids; 39855 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
Selected PDB 3D structures from and Proteopedia for ADH1B (see all 9):
1DEH (3D)        1HDX (3D)        1HDY (3D)        1HDZ (3D)        1HSZ (3D)        1HTB (3D)    
Secondary accessions: Q13711 Q4ZGI9 Q96KI7

Explore the universe of human proteins at neXtProt for ADH1B: NX_P00325

Explore proteomics data for ADH1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH1B (P00325) (see all 32)
     FSQYTVV  EVAPPKA  CLIGCGF  PQCGKCR 


    See ADH1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000659.2  NP_001273579.1  

    ENSEMBL proteins: 
     ENSP00000306606   ENSP00000425998   ENSP00000378351  
    Reactome Protein details: P00325

    ADH1B Human Recombinant Protein Products:

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    Novus Biologicals ADH1B Protein
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for ADH1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P00325

    ProtoNet protein and cluster: P00325

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH1B_HUMAN, P00325
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family


    Find genes that share domains with ADH1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH1B_HUMAN, P00325
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA9982
    GO:0008270zinc ion binding IDA9982
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with ADH1B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADH1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADH1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADH1B

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADH1B:
    hsa-miR-3910
    SwitchGear 3'UTR luciferase reporter plasmidADH1B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ADH1B (NM_000668)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADH1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH1B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADH1B_HUMAN, P00325: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    chloroplast1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ADH1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADH1B About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Celecoxib Pathway, Pharmacokinetics0.00
    Drug metabolism - cytochrome P4500.69
    2Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Phenylalanine metabolism
    Tyrosine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    5tryptophan utilization II
    tryptophan utilization II0.71
    serotonin degradation0.00
    tryptophan utilization I0.71


    Find genes that share SuperPaths with ADH1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ADH1B
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ADH1B
        Tyrosine metabolism p.1 (dopamine)

    Selected BioSystems Pathways for ADH1B (see all 7)
        ethanol degradation II
    serotonin degradation
    noradrenaline and adrenaline degradation
    acetone degradation I (to methylglyoxal)
    Fatty Acid Omega Oxidation

    1 Reactome Pathway for ADH1B
        Ethanol oxidation

    4 PharmGKB Pathways for ADH1B
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Celecoxib Pathway, Pharmacokinetics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH1B) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH1B: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADH1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADH1B (ENSP000003066064) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ADH1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADH1B

    Selected HMDB Compounds for ADH1B (see all 23)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--

    10 DrugBank Compounds for ADH1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fomepizole4-methylpyrazole (see all 4)7554-65-6targetinhibitor1590750 2573502 16946442 16871118 19458366 11391066
    EthanolAbsolute Alcohol (see all 34)64-17-5targetagonist18688716 21329681 21166830 19618839
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423 10592235
    Glycerol-- --target--17139284 17016423 10592235
    4-Iodopyrazole-- 3469-69-0target--17139284 17016423
    Cyclohexanol-- 108-93-0target--17139284 17016423
    N-Benzylformamide-- 6343-54-0target--17139284 17016423
    N-Heptylformamide-- --target--17139284 17016423
    NADHbeta-DPNH (see all 18)606-68-8target--16897483
    enzymesubstrate16897483 19583966
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423

    9 Novoseek inferred chemical compound relationships for ADH1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetaldehyde 83.2 25 7695788 (3), 8512495 (3), 19449376 (2), 16759795 (1) (see all 16)
    ethanol 68.7 45 11584144 (3), 8512495 (3), 20101753 (2), 10826103 (2) (see all 24)
    rsai 67.4 3 15318112 (1), 7557863 (1), 11696658 (1)
    mspi 27.5 1 11696658 (1)
    vitamin a 10.6 3 17279314 (2)
    oligonucleotide 3.7 3 8512495 (1), 9063814 (1)
    polyacrylamide 0 5 12705337 (1), 16135443 (1)
    glucose 0 4 18216179 (2), 16307179 (2)
    dopamine 0 3 16125912 (1), 15084894 (1)



    Find genes that share compounds with ADH1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADH1B gene (2 alternative transcripts): 
    NM_000668.5  NM_001286650.1  

    Unigene Cluster for ADH1B:

    Alcohol dehydrogenase 1B (class I), beta polypeptide
    Hs.4  [show with all ESTs]
    Unigene Representative Sequence: AF153821
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305046 ENST00000515694(uc003hut.4) ENST00000506651(uc011cei.1)
    ENST00000504498 ENST00000394887(uc003hus.4 uc011ceh.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ADH1B:
    hsa-miR-3910
    SwitchGear 3'UTR luciferase reporter plasmidADH1B 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ADH1B (NM_000668)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ADH1B
      QuantiFast Probe-based Assays in human, mouse, rat ADH1B

    Additional mRNA sequence: 

    AF153821.1 AK299409.1 AK301018.1 AK303945.1 AK304396.1 AK311712.1 AK316501.1 BC033009.2 
    D00137.1 M21692.1 M24317.1 X03350.1 

    Selected DOTS entries (see all 28):

    DT.91692319  DT.100798841  DT.100798848  DT.99980497  DT.121224179  DT.100798847  DT.91670613  DT.92469079 
    DT.121224294  DT.121224163  DT.92469055  DT.95283613  DT.121224238  DT.454964  DT.100798850  DT.92469117 
    DT.95158780  DT.121224235  DT.100001280  DT.121224120  DT.121224260  DT.415876  DT.91698740  DT.95361176 

    Selected AceView cDNA sequences (see all 475):

    CD519469 AV681652 BG546605 CB138240 CD014149 CB154296 CB147446 D58197 
    AA634614 AV709059 AA416884 CB267103 CB147187 AI262943 BX472538 CB141250 
    CB148337 CB134901 BX641105 BM856511 AU122152 CD014148 D00137 CB157572 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADH1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAGATTAT
    ADH1B Expression
    About this image


    ADH1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Ovary (Reproductive System)
     
     Liver (Hepatobiliary System)
    ADH1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADH1B: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ADH1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADH1B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    70(a)
    1 → many
    4(59594470-59604806)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    73(a)
    71(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    GL343323.1(1237604-1253112)
    GL343323.1(1263142-1274870)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685072 hypothetical protein MGC68507 73.24(n)    BC061682.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:635686
    zgc:779386
    (see all 4)
    zgc:77938
    (see all 4)
    57(a)
    57(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(37113161-37120779) ENSDARG00000087262
    14(37121611-37132341) ENSDARG00000088366
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    53(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    51(a)
    32(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADH1(YOL086C)4 Alcohol dehydrogenase, fermentative isozyme active more   --   15(160594-159548) 854068  NP_014555.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.100152 Triticum aestivum transcribed sequence with weak similarity more 72.22(n)    CK204158.1 
            Species with no ortholog for ADH1B

    ENSEMBL Gene Tree for ADH1B (if available)
    TreeFam Gene Tree for ADH1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADH1B gene
    ADH1C2  ADH62  ADH42  ADH1A2  ADH52  ADH72  
    7 SIMAP similar genes for ADH1B using alignment to 3 protein entries:     ADH1B_HUMAN (see all proteins):
    ADH1C    ADH1A    ADH7    ADH4    ADH5    ADH6
    SORD

    Find genes that share paralogs with ADH1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADH1B_HUMAN, P00325: Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2)
    corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of
    allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in
    most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and
    alcohol-related aerodigestive tract cancer [MIM:103720]


    Selected SNPs for ADH1B (see all 416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20667021,2,,4
    C,F,Hother1100030822(-) GTATCC/TGTACC 2 R C mis1 ese330Minor allele frequency- T:0.07MN NS EA NA WA EU 8635
    rs12299841,2,,4
    C,F,A,Hother1100041125(-) CTGTCG/ACACAG 2 /H /R mis138Minor allele frequency- A:0.12MN NS EA NA WA CSA EU 8478
    rs2021188831,2
    --95980611(+) CCACC-/GCCCCC 1 -- us2k10--------
    rs2005414641,2
    C--95980614(+) CCCCC-/ACCCCG 1 -- us2k10--------
    rs289139021,2
    C,F--95981700(-) GCTTTT/-CTATT 1 -- us2k15Minor allele frequency- -:0.10NS 182
    rs360382061,2
    C--95981701(+) AGAAA-/A/CGCAAA 1 -- us2k11NA 2
    rs1491255861,2
    --100028877(+) AAGCCA/GCAGAG 1 -- ds50010--------
    rs31331551,2
    C,F--100029017(+) GGCTGG/CTGTGC 1 -- ds5001 ese317Minor allele frequency- C:0.15NS NA WA CSA EA 557
    rs289147941,2
    C,F--100029093(-) CTACTC/GAGGAG 1 -- ds5001 ese35Minor allele frequency- G:0.21NS 184
    rs1908285651,2
    --100029122(+) GCCACC/TATGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADH1B (100226121 - 100242572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADH1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659036CNV Deletion23128226
    nsv879656CNV Gain21882294

    Human Gene Mutation Database (HGMD): ADH1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADH1B
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103720   
    OMIM disorders: 103780  
    8 diseases for ADH1B:    
    About MalaCards
    alcohol dependence, protection against    aerodigestive tract cancer, squamous cell, alcohol-related, protection against    alcohol-related birth defect    fetal alcohol syndrome
    liver cirrhosis    alcoholic liver cirrhosis    alcohol dependence    pancreatitis

    5 diseases from the University of Copenhagen DISEASES database for ADH1B:
    Alcohol dependence     Esophageal cancer     Substance abuse     Liver disease
    Squamous cell carcinoma

    Find genes that share disorders with ADH1B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADH1B gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 81.9 65 7625477 (4), 18299763 (3), 15519646 (3), 8773821 (3) (see all 37)
    pancreatitis alcoholic 69.6 6 8985275 (1), 15220553 (1), 11117576 (1), 8986224 (1) (see all 5)
    alcoholic cirrhosis 62.1 7 15220553 (1), 8845660 (1), 11748356 (1), 11966948 (1) (see all 5)
    liver diseases alcoholic 60.1 6 15519646 (3), 8591846 (1), 9194910 (1)
    chronic pancreatitis 52.5 6 17454860 (1), 18773092 (1), 11966948 (1), 1937384 (1) (see all 5)
    macrocytosis 43.8 1 16759795 (1)
    pancreatitis 41.7 2 8985275 (1), 10235286 (1)
    genetic susceptibility 40.4 2 19449376 (1), 16270392 (1)
    fetal alcohol syndrome 37.4 2 17618743 (1), 12461493 (1)
    cirrhosis 35.9 6 8985275 (1), 12915519 (1), 17454860 (1), 15519646 (1) (see all 5)

    Genetic Association Database (GAD): ADH1B
    Human Genome Epidemiology (HuGE) Navigator: ADH1B (205 documents)

    Export disorders for ADH1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADH1B gene, integrated from 10 sources (see all 409):
    (articles sorted by number of sources associating them with ADH1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)1, 4, 7 Nishimura F.T....Saijoh K. (amp 2009)
    2. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PubMed id 18322963)1, 4, 9 Guo Y.M....Guo Q.H. (World J. Gastroenterol. 2008)
    3. Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students. (PubMed id 11584144)1, 4, 9 Takeshita T....Morimoto K. (Alcohol. Clin. Exp. Res. 2001)
    4. Alcohol dehydrogenase 2 genotype and allelic variants are not associated with the risk for essential tremor. (PubMed id 17762315)1, 4, 9 MartA-nez C....JimAcnez-JimAcnez F.J. (Clin Neuropharmacol 2007)
    5. [Genetic polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 associated with the susceptibility on esophageal cancer]. (PubMed id 19799139)1, 4, 9 Ding J.H....Yao G.H. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    6. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population. (PubMed id 18439068)1, 4, 9 Ding J....Chang J. (Asian Pac. J. Cancer Prev. 2008)
    7. Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (PubMed id 17285601)1, 4, 9 Matsuo K....Tajima K. (Hum. Mutat. 2007)
    8. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. (PubMed id 15318096)1, 4, 9 Suzuki Y....Matsuoka K. (Alcohol. Clin. Exp. Res. 2004)
    9. Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males. (PubMed id 19452585)1, 4, 9 Ding J.H....Yao G.H. (World J. Gastroenterol. 2009)
    10. Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males. (PubMed id 18763293)1, 4, 9 Gao C.M....Tajima K. (World J. Gastroenterol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125 HGNC: 250 AceView: ADH1AandADH1BandADH1C Ensembl:ENSG00000196616 euGenes: HUgn125
    ECgene: ADH1B Kegg: 125 H-InvDB: ADH1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADH1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADH1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADH1B gene:
    Search GeneIP for patents involving ADH1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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