Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADH1B Gene

Aliases for ADH1B Gene

  • Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide 2 3 5
  • Alcohol Dehydrogenase Subunit Beta 3 4
  • EC 1.1.1.1 4 63
  • ADH2 3 4
  • Alcohol Dehydrogenase 2 (Class I), Beta Polypeptide 3
  • Epididymis Secretory Protein Li 117 3
  • Aldehyde Reductase 3
  • ADH, Beta Subunit 3
  • HEL-S-117 3
  • EC 1.1.1 63

External Ids for ADH1B Gene

Previous HGNC Symbols for ADH1B Gene

  • ADH2

Previous GeneCards Identifiers for ADH1B Gene

  • GC04M100473
  • GC04M100451
  • GC04M100456
  • GC04M100577
  • GC04M100226
  • GC04M095965

Summaries for ADH1B Gene

Entrez Gene Summary for ADH1B Gene

  • The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ADH1B Gene

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include alcohol dependence and alcoholic liver cirrhosis. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Fatty acid metabolism. GO annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH1B Gene

PharmGKB "VIP" Summary for ADH1B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1B Gene

Genomics for ADH1B Gene

Regulatory Elements for ADH1B Gene

Enhancers for ADH1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADH1B on UCSC Golden Path with GeneCards custom track

Genomic Location for ADH1B Gene

Chromosome:
4
Start:
99,304,964 bp from pter
End:
99,321,442 bp from pter
Size:
16,479 bases
Orientation:
Minus strand

Genomic View for ADH1B Gene

Genes around ADH1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1B Gene

Proteins for ADH1B Gene

  • Protein details for ADH1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00325-ADH1B_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1B
    Protein Accession:
    P00325
    Secondary Accessions:
    • A8MYN5
    • B4DRS9
    • B4DVC3
    • Q13711
    • Q4ZGI9
    • Q96KI7

    Protein attributes for ADH1B Gene

    Size:
    375 amino acids
    Molecular mass:
    39855 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH1B Gene

    Alternative splice isoforms for ADH1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADH1B Gene

Proteomics data for ADH1B Gene at MOPED

Post-translational modifications for ADH1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADH1B (ADH1B)

Domains & Families for ADH1B Gene

Gene Families for ADH1B Gene

Graphical View of Domain Structure for InterPro Entry

P00325

UniProtKB/Swiss-Prot:

ADH1B_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1B: view

Function for ADH1B Gene

Molecular function for ADH1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Enzyme Numbers (IUBMB) for ADH1B Gene

genes like me logo Genes that share phenotypes with ADH1B: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH1B Gene

Localization for ADH1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH1B Gene COMPARTMENTS Subcellular localization image for ADH1B gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
chloroplast 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADH1B Gene

Pathways & Interactions for ADH1B Gene

genes like me logo Genes that share pathways with ADH1B: view

Interacting Proteins for ADH1B Gene

Gene Ontology (GO) - Biological Process for ADH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH1B: view

No data available for SIGNOR curated interactions for ADH1B Gene

Drugs & Compounds for ADH1B Gene

(18) Drugs for ADH1B Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 1924
Fomepizole Approved Pharma inhibitor, Target 3
Vitamin A Approved Nutra 438
Zinc Approved Pharma 2102
Choline Approved Nutra 139

(26) Additional Compounds for ADH1B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
genes like me logo Genes that share compounds with ADH1B: view

Transcripts for ADH1B Gene

Unigene Clusters for ADH1B Gene

Alcohol dehydrogenase 1B (class I), beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1B Gene

No ASD Table

Relevant External Links for ADH1B Gene

GeneLoc Exon Structure for
ADH1B
ECgene alternative splicing isoforms for
ADH1B

Expression for ADH1B Gene

mRNA expression in normal human tissues for ADH1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH1B Gene

This gene is overexpressed in Liver (x7.6), Adipose - Subcutaneous (x7.1), Adipose - Visceral (Omentum) (x6.3), and Breast - Mammary Tissue (x4.2).

Protein differential expression in normal tissues from HIPED for ADH1B Gene

This gene is overexpressed in Nasopharynx (18.6), Liver (10.7), Liver, secretome (9.8), and Gallbladder (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1B Gene



SOURCE GeneReport for Unigene cluster for ADH1B Gene Hs.4

genes like me logo Genes that share expression patterns with ADH1B: view

Protein tissue co-expression partners for ADH1B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADH1B Gene

Orthologs for ADH1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH1B 35
  • 99.2 (n)
  • 99.47 (a)
ADH1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adh1 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh6 35
  • 67.29 (n)
  • 67.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68507 35
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 55 (a)
ManyToMany
adh8b 36
  • 52 (a)
ManyToMany
zgc:63568 36
  • 57 (a)
ManyToMany
zgc:77938 36
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 51 (a)
ManyToMany
Y50D4C.2 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 46 (a)
OneToMany
ADH1 38
wheat
(Triticum aestivum)
Liliopsida Ta.10015 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 55 (a)
OneToMany
Species with no ortholog for ADH1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ADH1B Gene

ENSEMBL:
Gene Tree for ADH1B (if available)
TreeFam:
Gene Tree for ADH1B (if available)

Paralogs for ADH1B Gene

Paralogs for ADH1B Gene

(7) SIMAP similar genes for ADH1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADH1B: view

Variants for ADH1B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1B Gene

P00325-ADH1B_HUMAN
Three alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol-related aerodigestive tract cancer [MIM:103720].

Sequence variations from dbSNP and Humsavar for ADH1B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1229984 - 99,318,162(-) CTGTC(A/G)CACAG reference, missense
rs2066702 - 99,307,860(-) GTATC(C/T)GTACC reference, missense
rs1041969 - 99,318,134(-) GGCAA(A/C)CTGGT reference, missense
rs6413413 - 99,318,127(+) TGGTG(A/T)CCCCC reference, missense
rs17033 -- 99,307,788(-) CCTAC(A/G)AGATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADH1B Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
esv2659036 CNV Deletion 23128226

Variation tolerance for ADH1B Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADH1B Gene

HapMap Linkage Disequilibrium report
ADH1B
Human Gene Mutation Database (HGMD)
ADH1B

Disorders for ADH1B Gene

MalaCards: The human disease database

(11) MalaCards diseases for ADH1B Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcohol dependence, protection against
alcoholic liver cirrhosis
  • alcoholic cirrhosis
fetal alcohol syndrome
  • alcohol-related neurodevelopmental disorder
alcoholic pancreatitis
  • pancreatitis alcoholic
methanol poisoning
- elite association - COSMIC cancer census association via MalaCards
Search ADH1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH1B

Genetic Association Database (GAD)
ADH1B
Human Genome Epidemiology (HuGE) Navigator
ADH1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH1B
genes like me logo Genes that share disorders with ADH1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1B Gene

Publications for ADH1B Gene

  1. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PMID: 18322963) Guo Y.M. … Guo Q.H. (World J. Gastroenterol. 2008) 3 23 48 67
  2. Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration. (PMID: 21166830) Matsumoto M. … Crabb D.W. (Alcohol. Clin. Exp. Res. 2011) 3 25 26
  3. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura F.T. … Saijoh K. (Nihon Arukoru Yakubutsu Igakkai Zasshi 2009) 3 25 26
  4. Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity. (PMID: 1590750) Yin S.J. … Lee S.C. (Biochem. Genet. 1992) 23 25 26
  5. Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? (PMID: 21329681) HernA!ndez-TobA-as A. … Riveros-Rosas H. (Chem. Biol. Interact. 2011) 25 26

Products for ADH1B Gene

Sources for ADH1B Gene

Content