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Aliases for ADH1A Gene

Aliases for ADH1A Gene

  • Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide 2 3
  • ADH1 3 4 6
  • Alcohol Dehydrogenase Subunit Alpha 3 4
  • EC 1.1.1.1 4 64
  • Alcohol Dehydrogenase 1 (Class I), Alpha Polypeptide 3
  • Alcohol Dehydrogenase 1A 3
  • Aldehyde Reductase 3
  • ADH, Alpha Subunit 3
  • EC 1.1.1 64

External Ids for ADH1A Gene

Previous Symbols for ADH1A Gene

  • ADH1

Summaries for ADH1A Gene

Entrez Gene Summary for ADH1A Gene

  • This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

GeneCards Summary for ADH1A Gene

ADH1A (Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ADH1A include alcohol dependence and fetal alcohol syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH1A Gene

PharmGKB "VIP" Summary for ADH1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1A Gene

Genomics for ADH1A Gene

Genomic Location for ADH1A Gene

Start:
99,276,366 bp from pter
End:
99,291,028 bp from pter
Size:
14,663 bases
Orientation:
Minus strand

Genomic View for ADH1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADH1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1A Gene

Regulatory Elements for ADH1A Gene

Proteins for ADH1A Gene

  • Protein details for ADH1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07327-ADH1A_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1A
    Protein Accession:
    P07327
    Secondary Accessions:
    • A8K3E3
    • Q17R68

    Protein attributes for ADH1A Gene

    Size:
    375 amino acids
    Molecular mass:
    39859 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

    Three dimensional structures from OCA and Proteopedia for ADH1A Gene

neXtProt entry for ADH1A Gene

Proteomics data for ADH1A Gene at MOPED

Post-translational modifications for ADH1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADH1A Gene

Gene Families for ADH1A Gene

HGNC:
  • ADH :Alcohol dehydrogenases

UniProtKB/Swiss-Prot:

ADH1A_HUMAN
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.:
    • P07327
genes like me logo Genes that share domains with ADH1A: view

Function for ADH1A Gene

Molecular function for ADH1A Gene

UniProtKB/Swiss-Prot CatalyticActivity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB) for ADH1A Gene

Gene Ontology (GO) - Molecular Function for ADH1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity TAS --
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA 9982
GO:0005515 protein binding IPI 16153155
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with ADH1A: view

Phenotypes for ADH1A Gene

GenomeRNAi human phenotypes for ADH1A:
genes like me logo Genes that share phenotypes with ADH1A: view

miRNA for ADH1A Gene

miRTarBase miRNAs that target ADH1A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADH1A Gene

Localization for ADH1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH1A Gene COMPARTMENTS Subcellular localization image for ADH1A gene
Compartment Confidence
cytosol 4
chloroplast 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADH1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADH1A: view

Pathways for ADH1A Gene

genes like me logo Genes that share pathways with ADH1A: view

Interacting Proteins for ADH1A Gene

Gene Ontology (GO) - Biological Process for ADH1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process NAS 2347582
GO:0006069 ethanol oxidation TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0017144 drug metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ADH1A: view

Compounds for ADH1A Gene

(24) HMDB Compounds for ADH1A Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
28822-73-3

(7) Drugbank Compounds for ADH1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Iodopyrazole
3469-69-0 target
Ethanol
  • Absolute Alcohol
64-17-5 target agonist
Fomepizole
  • 4-methylpyrazole
7554-65-6 target inhibitor
NADH
  • beta-DPNH
606-68-8 target
NADH
  • beta-DPNH
606-68-8 enzyme substrate

(5) Novoseek inferred chemical compound relationships for ADH1A Gene

Compound -log(P) Hits PubMed IDs
vitamin a 55.1 4
retinoid 51.4 1
acetaldehyde 50 2
ethanol 45.1 7
retinoic acid 43.3 5
genes like me logo Genes that share compounds with ADH1A: view

Transcripts for ADH1A Gene

mRNA/cDNA for ADH1A Gene

Unigene Clusters for ADH1A Gene

Alcohol dehydrogenase 1A (class I), alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ADH1A Gene

GeneLoc Exon Structure for
ADH1A
ECgene alternative splicing isoforms for
ADH1A

Expression for ADH1A Gene

mRNA expression in normal human tissues for ADH1A Gene

mRNA differential expression in normal tissues according to GTEx for ADH1A Gene

This gene is overexpressed in Liver (45.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADH1A Gene

SOURCE GeneReport for Unigene cluster for ADH1A Gene Hs.654433

genes like me logo Genes that share expressions with ADH1A: view

Orthologs for ADH1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADH1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH1A 36
  • 99.2 (n)
  • 98.67 (a)
ADH1B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adh1 37
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh1 36
  • 65.69 (n)
  • 66.93 (a)
zebrafish
(Danio rerio)
Actinopterygii adh8a 37
  • 55 (a)
ManyToMany
adh8b 37
  • 52 (a)
ManyToMany
zgc:63568 37
  • 57 (a)
ManyToMany
zgc:77938 37
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 37
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 37
  • 51 (a)
ManyToMany
Y50D4C.2 37
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADH7 39
SFA1 37
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 37
  • 55 (a)
OneToMany
Species with no ortholog for ADH1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH1A Gene

ENSEMBL:
Gene Tree for ADH1A (if available)
TreeFam:
Gene Tree for ADH1A (if available)

Paralogs for ADH1A Gene

Paralogs for ADH1A Gene

Selected SIMAP similar genes for ADH1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADH1A: view

Variants for ADH1A Gene

Structural Variations from Database of Genomic Variants (DGV) for ADH1A Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
esv2659036 CNV Deletion 23128226

Relevant External Links for ADH1A Gene

HapMap Linkage Disequilibrium report
ADH1A

No data available for Sequence variations from dbSNP and Humsavar for ADH1A Gene

Disorders for ADH1A Gene

(1) University of Copenhagen DISEASES for ADH1A Gene

Relevant External Links for ADH1A

Genetic Association Database (GAD)
ADH1A
Human Genome Epidemiology (HuGE) Navigator
ADH1A
genes like me logo Genes that share disorders with ADH1A: view

No data available for UniProtKB/Swiss-Prot for ADH1A Gene

Publications for ADH1A Gene

  1. The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. (PMID: 2347582) Yasunami M. … Yoshida A. (Genomics 1990) 3 4 23
  2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X. … Gelernter J. (Am. J. Hum. Genet. 2006) 3 23 49
  3. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura F.T. … Saijoh K. (Nihon Arukoru Yakubutsu Igakkai Zasshi 2009) 3 25 49
  4. Molecular structure of the human alcohol dehydrogenase 1 gene. (PMID: 2920825) Matsuo Y. … Yokoyama S. (FEBS Lett. 1989) 3 4
  5. Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. (PMID: 2935875) Ikuta T. … Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4

Products for ADH1A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADH1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADH1A
    • Block miRNA regulation of ADH1A using miScript Target Protectors

    Sources for ADH1A Gene

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