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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADH1A Gene

protein-coding GIFtS: 62
GCID: GC04M100197

alcohol dehydrogenase 1A (class I), alpha polypeptide

(Previous symbol: ADH1)

Explore 23 diseases affiliated with
ADH1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide¹ ²		Alcohol Dehydrogenase 1 (Class I), Alpha Polypeptide²
ADH1¹ ² ³ ⁵		Alcohol Dehydrogenase 1A²
Alcohol Dehydrogenase Subunit Alpha² ³		Aldehyde Reductase²
EC 1.1.1.1³ ⁸		EC 1.1.1⁸
ADH, Alpha Subunit²

External Ids:	HGNC: 249¹	Entrez Gene: 124²	Ensembl: ENSG00000187758⁷	OMIM: 103700⁵	UniProtKB: P07327³

Export aliases for ADH1A gene to outside databases

Previous GC identifers: GC04M100444 GC04M100450 GC04M100655 GC04M100554 GC04M095935

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADH1A:

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I

alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol

dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life

but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase

genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene

may contribute to variation in certain personality traits and substance dependence. (provided by RefSeq, Nov 2010)

Gene Wiki entry for ADH1A

PharmGKB "VIP" summary for ADH1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADH1A gene promoter:
GR ATF-2 CUTL1 HEN1 IRF-2 CP2 POU2F1 GR-alpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ADH1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

ADH1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1A gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M100197: view genomic region (about GC identifiers)

Start:	100,197,524 bp from pter	End:	100,212,185 bp from pter
Size:	14,662 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327 (See protein sequence)

Recommended Name: Alcohol dehydrogenase 1A

Size: 375 amino acids; 39859 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma

Subcellular location: Cytoplasm

Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to

class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6

2 PDB 3D structures from and Proteopedia for ADH1A:

1HSO (3D)

1U3T (3D)

Secondary accessions: A8K3E3 Q17R68

Explore the universe of human proteins at neXtProt for ADH1A: NX_P07327

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07327

4/31 DME Specific Peptides for ADH1A (P07327) (see all 31)

CINPQDY

FSQYTVV

EVAPPKA

CLIGCGF

ADH1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000658.1

ENSEMBL proteins:

ENSP00000209668

Reactome Protein details: P07327
Human Recombinant Protein Products for ADH1A:

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	Uscn Proteins for ADH1A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ADH1A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ADH1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADH1A for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013149 ADH_C

IPR011032 GroES-like

IPR016040 NAD(P)-bd_dom

IPR002328 ADH_Zn_CS

IPR013154 ADH_GroES-like

Graphical View of Domain Structure for InterPro Entry P07327

ProtoNet protein and cluster: P07327

2 Blocks protein families:

IPB002328 Zinc-containing alcohol dehydrogenase

IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADH1A_HUMAN, P07327

Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

Enzyme Numbers (IUBMB): EC 1.1.1.1¹ ² EC 1.1.1²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004022	alcohol dehydrogenase (NAD) activity	TAS	--
GO:0004024	alcohol dehydrogenase activity, zinc-dependent	IDA	9982
GO:0005515	protein binding	IPI	16153155
GO:0008270	zinc ion binding	IEA	--

ADH1A for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADH1A:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADH1A

miRNA Products:		OriGene 3'-UTR Clone: ADH1A Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ADH1A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ethanol oxidation

	Ethanol oxidation	1.00			Cyclophosphamide Pathway, Pharmacodynamics	0.42
	Fatty Acid Omega Oxidation	0.47

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Abacavir transport and metabolism

Abacavir transport and metabolism

1.00

Abacavir metabolism

0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Vitamin A and carotenoid metabolism

Vitamin A and carotenoid metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ADH1A

	Vitamin A and carotenoid metabolism
	Fatty Acid Omega Oxidation

5/6 Reactome Pathways for ADH1A (see all 6)

	Ethanol oxidation
	Abacavir metabolism
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

2 PharmGKB Pathways for ADH1A

	Celecoxib Pathway, Pharmacokinetics
	Cyclophosphamide Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for ADH1A) (see all 7):

	Glycolysis / Gluconeogenesis
	Fatty acid metabolism
	Tyrosine metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450

ADH1A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADH1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for ADH1A (ENSP00000209668⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALDH1A1	ENSP00000297785⁴	STRING: ENSP00000297785
ALDH1A2	ENSP00000249750⁴	STRING: ENSP00000249750
ALDH1A3	ENSP00000332256⁴	STRING: ENSP00000332256
ALDH1B1	ENSP00000366927⁴	STRING: ENSP00000366927
ALDH2	ENSP00000261733⁴	STRING: ENSP00000261733

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006066	alcohol metabolic process	NAS	2347582
GO:0006069	ethanol oxidation	TAS	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0017144	drug metabolic process	TAS	--

ADH1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADH1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADH1A

10/24 HMDB Compounds for ADH1A (see all 24) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Butanol	1-Butanol (see all 10)	71-36-3	--
1-Hexanol	1-Hexyl alcohol (see all 30)	111-27-3	--
1-Pentanol	1-Pentol (see all 34)	71-41-0	--
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylglycol	(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)	28822-73-3	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
3a,7a-Dihydroxy-5b-cholestane	5beta-Cholestane-3alpha,7alpha-diol (see all 5)	3862-26-8	--
9-cis-Retinal	9-cis-Retinal (see all 5)	514-85-2	--
Acetaldehyde	acetaldehyde (see all 5)	75-07-0	--
Betaine aldehyde	(Formylmethyl)trimethylammonium (see all 8)	7418-61-3	--

6 DrugBank Compounds for ADH1A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fomepizole	4-methylpyrazole (see all 4)	7554-65-6	target	inhibitor	16946442 16871118 2789998 16790752 19458366 8997246
Ethanol	Absolute Alcohol (see all 34)	64-17-5	target	agonist	18688716 21329681 21166830 19618839
N-Cyclopentyl-N-Cyclobutylformamide	--	--	target	--	17139284 17016423 10592235
NADH	beta-DPNH (see all 18)	606-68-8	target	--	16760478 16897483
NADH	beta-DPNH (see all 18)	606-68-8	enzyme	substrate	16760478 16897483 19583966
4-Iodopyrazole	--	3469-69-0	target	--	17139284 17016423
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423

5 Novoseek chemical compound relationships for ADH1A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin a	55.1	6	18343808 (1), 15096205 (1), 19011747 (1), 17553814 (1)
retinoid	51.4	1	17553814 (1)
acetaldehyde	50	3	16790752 (1), 18304535 (1)
ethanol	45.1	7	19489444 (2), 16153155 (1), 16790752 (1), 16453102 (1) (see all 6)
retinoic acid	43.3	5	1996113 (2), 18343808 (1), 7748347 (1), 19011747 (1)

Search CenterWatch for drugs/clinical trials and news about ADH1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADH1A gene:

NM_000667.3

Unigene Cluster for ADH1A:

Alcohol dehydrogenase 1A (class I), alpha polypeptide

Hs.654433 [show with all ESTs]

Unigene Representative Sequence: NM_000667

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000209668(uc003hur.2) ENST00000503461(uc010ilf.1 uc010ilg.2)

ENST00000511656

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Additional cDNA sequence:

AK290558.1 AK309597.1 BC074738.2 BC117442.1 BC126306.1 BT019812.1 M12271.1 M12963.1

16 DOTS entries:

DT.121224262 DT.92469055 DT.95158774 DT.100030344 DT.415876 DT.91692319 DT.99980497 DT.100798850

DT.121224274 DT.92469032 DT.100001280 DT.100798839 DT.100798841 DT.100798842 DT.101985267 DT.91679459

24/475 AceView cDNA sequences (see all 475):

CB241024 CB137629 CB148959 BI517854 AU122403 AA416884 AI796953 BX119792

AI581294 CB147187 CD014149 BG564896 NM_000668 CB138273 CD172162 CB132385

BP381206 CB162202 BI832910 AI275907 BC074738 CB141250 CB138229 CB147446

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH1A About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c
SP1:													-				-		-		-		-		-
SP2:															-
SP3:													-
SP4:

ECgene alternative splicing isoforms for ADH1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADH1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ADH1A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADH1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADH1A

SOURCE GeneReport for Unigene cluster: Hs.654433

SABiosciences Expression via Pathway-Focused PCR Array including ADH1A:

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ADH1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ADH1A gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NI80_CHICK⁶	Uncharacterized protein	72(a)	1 → many	4(61579079-61589162)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	70(a) 67(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343323.1(1237922-1251279) GL343323.1(1380739-1391213)
zebrafish (Danio rerio)	Actinopterygii	zgc:77938⁶ zgc:63568⁶ (see all 4)	zgc:63568 (see all 4)	58(a) 57(a) (see all 4)	many ↔ many many ↔ many (see all 4)	14(37121611-37132341) 14(37113161-37120779)
fruit fly (Drosophila melanogaster)	Insecta	Fdh⁶	Formaldehyde dehydrogenase	51(a)	1 → many	3R(6696628-6698102)
worm (Caenorhabditis elegans)	Secernentea	H24K24.3⁶ Y50D4C.2⁶	Protein Y50D4C.2	49(a) 31(a)	many ↔ many many ↔ many	V(911775-916461) V(936399-939368)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATGSNOR1⁶ ADH1⁶ (see all 9)	alcohol dehydrogenase class-P (see all 9)	50(a) 49(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(17684156-17686534) 1(28975394-28977417)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	dehydrogenase, putative, expressed (see all 9)	50(a) 48(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2(34924401-34928315) 11(5740713-5743904)
E. coli (Escherichia coli)	Gamma proteobacteria	frmA⁶ yphC⁶	alcohol dehydrogenase class III/glutathione-depend... predicted oxidoreductase, Zn-dependent and NAD(P)-...	47(a) 25(a)	1 ↔ many possible ortholog	Chromosome(377686-378795) Chromosome(2672722-2673783)

ENSEMBL Gene Tree for ADH1A (if available)
TreeFam Gene Tree for ADH1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADH1A gene

ADH6² ADH4² ADH1B² ADH5² ADH7²

6 SIMAP similar genes for ADH1A using alignment to 1 protein entry: ADH1A_HUMAN:

ADH1C ADH1B ADH7 ADH5 ADH4 ADH6

ADH1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111427122^1,2		--	100197063(+)	`TTTGCG/AATTAG`	2	--	ds500¹ int¹		1		CSA	2
rs150859876^1,2		--	100197126(+)	`CAATTA/GTATAT`	2	--	int¹ ds500¹		0	--	--	--	--
rs28364342^1,2	C,F,H	--	100197176(-)	`ACAGTG/TAAGGA`	2	--	ds500¹ int¹		12		NS NA WA	1086
rs5860573^1,2	C,F	--	100197320(+)	`TTATTA/-AAAAA`	2	--	ds500¹ int¹		3		NA	6
rs201791743^1,2	C	--	100197332(+)	`AAAAAA/GGGCGA`	2	--	int¹ ds500¹		0	--	--	--	--
rs17584149^1,2	C,F	--	100197335(+)	`AAAGGC/TGAAAA`	2	--	ds500¹ int¹		3		NA	142
rs115482644^1,2	F	--	100197336(+)	`AAGGCG/AAAAAT`	2	--	int¹ ds500¹		1		NA	120
rs188805263^1,2		--	100197344(+)	`AATGCC/TGACAG`	2	--	int¹ ds500¹		0	--	--	--	--
rs7684674^1,2	C,F,H	--	100197359(+)	`AATTGA/CGATAG`	2	--	ds500¹ int¹		27		NA NS EA WA CSA	2052
rs192035201^1,2		--	100197492(+)	`AAATAC/GCTTTT`	2	--	ds500¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADH1A (100197524 - 100212185 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADH1A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADH1A for disorders           About GeneDecksing

OMIM gene information: 103700    OMIM disorders: --

20/23 diseases for ADH1A (see all 23):    About MalaCards

alcoholism substance dependence uterine fibroid fetal alcohol syndrome

alcoholic liver cirrhosis drug dependence liver cirrhosis alcohol dependence

intrahepatic cholangiocarcinoma squamous cell carcinoma anoxia adhd

cholangiocarcinoma parkinson's disease endometrial cancer pancreatic cancer

colorectal cancer breast cancer pancreatitis pneumonia

1 disease from the University of Copenhagen DISEASES database for ADH1A:

Alcohol dependence

Genetic Association Database (GAD): ADH1A
Human Genome Epidemiology (HuGE) Navigator: ADH1A (24 documents)

Export disorders for ADH1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADH1A gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with ADH1A)

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world of online information

The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. (PubMed id 2347582)^{1, 2, 9} Yasunami M.... Yoshida A. (1990)
Effects of polymorphisms in untranslated regions of t he class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)^{1, 7} Nishimura F.T....Saijoh K. (2009)
Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital. (PubMed id 15279067)^{1, 4} Nishio K....Hamajima N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Alcohol dehydrogenase polymorphism and Parkinson's disease. (PubMed id 11356310)^{1, 4} Tan E.K....Ashizawa T. (2001)
Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx. (PubMed id 11303599)^{1, 4} Sturgis E.M....Wei Q. (2001)
Molecular structure of the human alcohol dehydrogenase 1 gene. (PubMed id 2920825)^{1, 2} Matsuo Y. and Yokoyama S. (1989)
cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase. (PubMed id 3013304)^{1, 2} von Bahr-Lindstroem H.... Joernvall H. (1986)
Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. (PubMed id 2935875)^{1, 2} Ikuta T.... Yoshida A. (1986)
Genetics of human alcohol and aldehyde dehydrogenases. (PubMed id 3006456)^{1, 3} Smith M. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 124	HGNC: 249	AceView: ADH1AandADH1BandADH1C	Ensembl:ENSG00000187758	euGenes: HUgn124
ECgene: ADH1A	Kegg: 124	H-InvDB: ADH1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADH1A	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/adh1a/

Intellectual Property for ADH1A gene
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Patent Information for ADH1A gene:
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ADH1A Gene

alcohol dehydrogenase 1A (class I), alpha polypeptide

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ADH1A Gene

alcohol dehydrogenase 1A (class I), alpha polypeptide

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