Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADH1A Gene

protein-coding   GIFtS: 61
GCID: GC04M100197

Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide


(Previous symbol: ADH1)
  See ADH1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide1 2     Alcohol Dehydrogenase 1 (Class I), Alpha Polypeptide2
ADH11 2 3 5     Alcohol Dehydrogenase 1A2
Alcohol Dehydrogenase Subunit Alpha2 3     Aldehyde Reductase2
EC 1.1.1.13 8     EC 1.1.18
ADH, Alpha Subunit2     

External Ids:    HGNC: 2491   Entrez Gene: 1242   Ensembl: ENSG000001877587   OMIM: 1037005   UniProtKB: P073273   

Export aliases for ADH1A gene to outside databases

Previous GC identifers: GC04M100444 GC04M100450 GC04M100655 GC04M100554 GC04M095935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADH1A Gene:
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class
I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits.
Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early
fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol
dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4.
Mutations in this gene may contribute to variation in certain personality traits and substance dependence.
(provided by RefSeq, Nov 2010)

GeneCards Summary for ADH1A Gene:
ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide) is a protein-coding gene. Diseases associated with ADH1A include fetal alcohol syndrome, and alcohol dependence. GO annotations related to this gene include alcohol dehydrogenase (NAD) activity and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH1A Gene

PharmGKB "VIP" summary for ADH1A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADH1A gene promoter:
         GR   ATF-2   CUTL1   HEN1   IRF-2   CP2   POU2F1   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ADH1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100197:  view genomic region     (about GC identifiers)

Start:
100,197,523 bp from pter      End:
100,212,185 bp from pter
Size:
14,663 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 1A  
Size: 375 amino acids; 39859 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
2 PDB 3D structures from and Proteopedia for ADH1A:
1HSO (3D)        1U3T (3D)    
Secondary accessions: A8K3E3 Q17R68

Explore the universe of human proteins at neXtProt for ADH1A: NX_P07327

Explore proteomics data for ADH1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADH1A (P07327) (see all 31)
     CINPQDY  FSQYTVV  EVAPPKA  CLIGCGF 


    See ADH1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000658.1  
    ENSEMBL proteins: 
     ENSP00000209668  
    Reactome Protein details: P07327

    ADH1A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ADH1A
    OriGene Protein Over-expression Lysate for ADH1A
    OriGene MassSpec for ADH1A
    OriGene Custom Protein Services for ADH1A
    GenScript Custom Purified and Recombinant Proteins Services for ADH1A
    Novus Biologicals ADH1A Proteins
    Novus Biologicals ADH1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ADH1A
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ADH1A 

     
    antibodies-online proteins for ADH1A (8 products) 

     
    antibodies-online peptides for ADH1A

    ADH1A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADH1A
    OriGene Custom Antibody Services for ADH1A
    Novus Biologicals ADH1A Antibodies
    Abcam antibodies for ADH1A (P07327, P00325)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ADH1A
    antibodies-online antibodies for ADH1A (22 products) 

    ADH1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADH1A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADH1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ADH1A 
    antibodies-online kits for ADH1A (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ADH: Alcohol dehydrogenases

    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P07327

    ProtoNet protein and cluster: P07327

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family


    Find genes that share domains with ADH1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH1A_HUMAN, P07327
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity TAS--
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA9982
    GO:0005515protein binding IPI16153155
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with ADH1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADH1A:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADH1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADH1A:
    hsa-mir-132-3p (MIRT021722)

    Block miRNA regulation of human, mouse, rat ADH1A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ADH1A
    SwitchGear 3'UTR luciferase reporter plasmidADH1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADH1A
    Predesigned siRNA for gene silencing in human, mouse, rat ADH1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADH1A

    Clone
    Products:
         
    OriGene clones in human, mouse for ADH1A (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADH1A (NM_000667)
    Sino Biological Human cDNA Clone for ADH1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADH1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH1A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADH1A
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADH1A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ADH1A_HUMAN, P07327: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    chloroplast2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ADH1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADH1A About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Celecoxib Pathway, Pharmacokinetics0.00
    Drug metabolism - cytochrome P4500.69
    2Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Cyclophosphamide Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.00
    5Abacavir transport and metabolism
    Abacavir transport and metabolism
    Abacavir metabolism0.00


    Find genes that share SuperPaths with ADH1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ADH1A
        Vitamin A and carotenoid metabolism
    Fatty Acid Omega Oxidation


    2 Reactome Pathways for ADH1A
        Ethanol oxidation
    Abacavir metabolism

    4 PharmGKB Pathways for ADH1A
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Celecoxib Pathway, Pharmacokinetics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADH1A) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Array including ADH1A: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADH1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADH1A (ENSP000002096684) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process NAS2347582
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0017144drug metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with ADH1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADH1A

    Selected HMDB Compounds for ADH1A (see all 24)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    3a,7a-Dihydroxy-5b-cholestane5beta-Cholestane-3alpha,7alpha-diol (see all 5)3862-26-8--
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--

    6 DrugBank Compounds for ADH1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fomepizole4-methylpyrazole (see all 4)7554-65-6targetinhibitor16946442 16871118 2789998 16790752 19458366 8997246
    EthanolAbsolute Alcohol (see all 34)64-17-5targetagonist18688716 21329681 21166830 19618839
    N-Cyclopentyl-N-Cyclobutylformamide-- --target--17139284 17016423 10592235
    NADHbeta-DPNH (see all 18)606-68-8target--16760478 16897483
    enzymesubstrate16760478 16897483 19583966
    4-Iodopyrazole-- 3469-69-0target--17139284 17016423
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for ADH1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 55.1 6 18343808 (1), 15096205 (1), 19011747 (1), 17553814 (1)
    retinoid 51.4 1 17553814 (1)
    acetaldehyde 50 3 16790752 (1), 18304535 (1)
    ethanol 45.1 7 19489444 (2), 16153155 (1), 16790752 (1), 16453102 (1) (see all 6)
    retinoic acid 43.3 5 1996113 (2), 18343808 (1), 7748347 (1), 19011747 (1)



    Find genes that share compounds with ADH1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADH1A gene: 
    NM_000667.3  

    Unigene Cluster for ADH1A:

    Alcohol dehydrogenase 1A (class I), alpha polypeptide
    Hs.654433  [show with all ESTs]
    Unigene Representative Sequence: NM_000667
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209668(uc003hur.2) ENST00000503461(uc010ilf.1 uc010ilg.2)
    ENST00000511656
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADH1A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ADH1A
    SwitchGear 3'UTR luciferase reporter plasmidADH1A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADH1A
    Predesigned siRNA for gene silencing in human, mouse, rat ADH1A
    Clone
    Products:
         
    OriGene clones in human, mouse for ADH1A (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADH1A (NM_000667)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADH1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH1A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADH1A
    OriGene qSTAR qPCR primer pairs in human, mouse for ADH1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADH1A
      QuantiTect SYBR Green Assays in human, mouse, rat ADH1A
      QuantiFast Probe-based Assays in human, mouse, rat ADH1A

    Additional mRNA sequence: 

    AK290558.1 AK309597.1 BC074738.2 BC117442.1 BC126306.1 BT019812.1 M12271.1 M12963.1 

    16 DOTS entries:

    DT.121224262  DT.92469055  DT.95158774  DT.100030344  DT.415876  DT.91692319  DT.99980497  DT.100798850 
    DT.121224274  DT.92469032  DT.100001280  DT.100798839  DT.100798841  DT.100798842  DT.101985267  DT.91679459 

    Selected AceView cDNA sequences (see all 475):

    CD014149 CA427955 NM_000667 BX472538 NM_000668 AV681854 AA634614 BM980353 
    CB138229 AI262943 CB147187 CB139103 CB141250 CD519469 AI612740 CD172162 
    CB137629 CB138242 BC074738 AI275907 C00945 BG564896 D58197 CB148337 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH1A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                      -           -     -     -     -     -               
    SP2:                                            -                                             
    SP3:                                      -                                                   
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ADH1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADH1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADH1A Expression
    About this image

    ADH1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADH1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654433
        Pathway & Disease-focused RT2 Profiler PCR Array including ADH1A: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADH1A
    OriGene qSTAR qPCR primer pairs in human, mouse for ADH1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADH1A
    QuantiTect SYBR Green Assays in human, mouse, rat ADH1A
    QuantiFast Probe-based Assays in human, mouse, rat ADH1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADH1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    69(a)
    1 → many
    4(59594470-59604806)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    Uncharacterized protein
    (see all 7)
    72(a)
    70(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343323.1(1237604-1253112)
    GL343323.1(1263142-1274870)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adh11 alcohol dehydrogenase 1 65.69(n)
    66.93(a)
      496861  NM_001011391.1  NP_001011391.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:779386
    zgc:635686
    (see all 4)
    zgc:63568
    (see all 4)
    58(a)
    57(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(37121611-37132341) ENSDARG00000088366
    14(37113161-37120779) ENSDARG00000087262
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    53(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2 (Y50D4C.2) mRNA, complete cds
    51(a)
    32(a)
    many ↔ many
    many ↔ many
    V(911776-916460) WBGene00019240
    V(936398-939367) WBGene00021747
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADH7(YCR105W)4 NADPH-dependent medium chain alcohol dehydrogenase more   --   3(309070-310155) 850469  NP_010030.1 
            Species with no ortholog for ADH1A

    ENSEMBL Gene Tree for ADH1A (if available)
    TreeFam Gene Tree for ADH1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADH1A gene
    ADH1C2  ADH62  ADH42  ADH1B2  ADH52  ADH72  
    6 SIMAP similar genes for ADH1A using alignment to 1 protein entry:     ADH1A_HUMAN:
    ADH1C    ADH1B    ADH7    ADH5    ADH4    ADH6

    Find genes that share paralogs with ADH1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADH1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659036CNV Deletion23128226
    nsv879656CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADH1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ADH1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 103700    OMIM disorders: --

    2 diseases for ADH1A:    
    About MalaCards
    fetal alcohol syndrome    alcohol dependence

    1 disease from the University of Copenhagen DISEASES database for ADH1A:
    Alcohol dependence

    Find genes that share disorders with ADH1A           About GenesLikeMe

    Genetic Association Database (GAD): ADH1A
    Human Genome Epidemiology (HuGE) Navigator: ADH1A (24 documents)

    Export disorders for ADH1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADH1A gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with ADH1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)1, 4, 7 Nishimura F.T....Saijoh K. (amp 2009)
    2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)1, 4, 9 Luo X....Gelernter J. (Am. J. Hum. Genet. 2006)
    3. The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. (PubMed id 2347582)1, 2, 9 Yasunami M.... Yoshida A. (Genomics 1990)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. ADH1A variation predisposes to personality traits and substance dependence. (PubMed id 19526455)1, 4 Zuo L....Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    8. ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (PubMed id 19193628)1, 4 Birley A.J....Whitfield J.B. (Hum. Mol. Genet. 2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 124 HGNC: 249 AceView: ADH1AandADH1BandADH1C Ensembl:ENSG00000187758 euGenes: HUgn124
    ECgene: ADH1A Kegg: 124 H-InvDB: ADH1A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADH1A Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADH1A gene:
    Search GeneIP for patents involving ADH1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADH1A   OriGene RNAi products in human, mouse, rat for ADH1A  
     OriGene qPCR primer pairs and template standards for ADH1A   OriGene Protein Over-expression Lysate for ADH1A  
     OriGene MassSpec for ADH1A   OriGene clones in human, mouse for ADH1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADH1A   OriGene Purified Protein for ADH1A  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADH1A   OriGene Custom Protein Services for ADH1A  

     
     
     Block miRNA regulation of human, mouse, rat ADH1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADH1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADH1A Predesigned siRNA for gene silencing in human, mouse, rat ADH1A
     QuantiFast Probe-based Assays in human, mouse, rat ADH1A QuantiTect SYBR Green Assays in human, mouse, rat ADH1A
     PCR Arrays including human, mouse, rat ADH1A Search Chromatin IP Primers for ADH1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ADH1A  GeneGlobe Interaction Network for ADH1A
     Regulatory tfbs in ADH1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADH1A GenScript cDNA clones with any tag delivered in your preferred vector for ADH1A
     GenScript Custom Assay Services for ADH1A GenScript Custom overexpressing Cell Line Services for ADH1A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ADH1A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ADH1A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADH1A antibodies
     ADH1A proteins
     ADH1A lysates
     Antibodies for ADH1A
     See all of Abcam's Antibodies, Kits and Proteins for ADH1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ADH1A
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADH1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADH1A
     SwitchGear 3'UTR luciferase reporter plasmids for ADH1A
     Browse SwitchGear Promoter luciferase reporter plasmids for ADH1A
     ThermoFisher Antibodies for ADH1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADH1A
     Browse compounds at ApexBio
     Search Addgene for plasmids for ADH1A
      Search eBioscience for proteins for ADH1A
      Search eBioscience for elisas for ADH1A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ADH1A
     antibodies-online antibodies for ADH1A (22 products)
     antibodies-online kits for ADH1A (6 products)
     antibodies-online peptides for ADH1A
     antibodies-online proteins for ADH1A (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADH1A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4