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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADH1A Gene

protein-coding   GIFtS: 61
GCID: GC04M100197

Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide


(Previous symbol: ADH1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide1 2     Alcohol Dehydrogenase 1 (Class I), Alpha Polypeptide2
ADH11 2 3 5     Alcohol Dehydrogenase 1A2
Alcohol Dehydrogenase Subunit Alpha2 3     Aldehyde Reductase2
EC 1.1.1.13 8     EC 1.1.18
ADH, Alpha Subunit2     

External Ids:    HGNC: 2491   Entrez Gene: 1242   Ensembl: ENSG000001877587   OMIM: 1037005   UniProtKB: P073273   

Export aliases for ADH1A gene to outside databases

Previous GC identifers: GC04M100444 GC04M100450 GC04M100655 GC04M100554 GC04M095935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADH1A Gene:
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class
I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits.
Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early
fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol
dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4.
Mutations in this gene may contribute to variation in certain personality traits and substance dependence.
(provided by RefSeq, Nov 2010)

GeneCards Summary for ADH1A Gene: 
ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide) is a protein-coding gene. Diseases associated with ADH1A include uterine fibroid, and anoxia, and among its related super-pathways are Ifosfamide Pathway, Pharmacodynamics and Metabolic pathways. GO annotations related to this gene include nucleotide binding and alcohol dehydrogenase activity, zinc-dependent. An important paralog of this gene is ADH1C.

Gene Wiki entry for ADH1A Gene

PharmGKB "VIP" summary for ADH1A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADH1A gene promoter:
         GR   ATF-2   CUTL1   HEN1   IRF-2   CP2   POU2F1   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADH1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADH1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

ADH1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADH1A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100197:  view genomic region     (about GC identifiers)

Start:
100,197,523 bp from pter      End:
100,212,185 bp from pter
Size:
14,663 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327 (See protein sequence)
Recommended Name: Alcohol dehydrogenase 1A  
Size: 375 amino acids; 39859 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Dimer of identical or non-identical chains of three types; alpha, beta and gamma
Subcellular location: Cytoplasm
Miscellaneous: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma,
one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6
2 PDB 3D structures from and Proteopedia for ADH1A:
1HSO (3D)        1U3T (3D)    
Secondary accessions: A8K3E3 Q17R68

Explore the universe of human proteins at neXtProt for ADH1A: NX_P07327

Explore proteomics data for ADH1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07327

  • 4/31 DME Specific Peptides for ADH1A (P07327) (see all 31)
     CINPQDY  FSQYTVV  EVAPPKA  CLIGCGF 

    ADH1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADH1A Protein Expression
    REFSEQ proteins: NP_000658.1  
    ENSEMBL proteins: 
     ENSP00000209668  
    Reactome Protein details: P07327
    Human Recombinant Protein Products for ADH1A: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    ADH1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADH: Alcohol dehydrogenases

    5/6 InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR002328 ADH_Zn_CS
     IPR013154 ADH_GroES-like

    Graphical View of Domain Structure for InterPro Entry P07327

    ProtoNet protein and cluster: P07327

    2 Blocks protein domains:
    IPB002328 Zinc-containing alcohol dehydrogenase
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: ADH1A_HUMAN, P07327
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family


    ADH1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADH1A_HUMAN, P07327
    Catalytic activity: An alcohol + NAD(+) = an aldehyde or ketone + NADH

         Enzyme Numbers (IUBMB): EC 1.1.1.11 2 EC 1.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004022alcohol dehydrogenase (NAD) activity TAS--
    GO:0004024alcohol dehydrogenase activity, zinc-dependent IDA9982
    GO:0005515protein binding IPI16153155
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
         
    ADH1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADH1A:
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADH1A About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ifosfamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics0.72
    Ethanol oxidation0.50
    Cyclophosphamide Pathway, Pharmacodynamics0.72
    Fatty Acid Omega Oxidation0.47
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    Drug metabolism - cytochrome P4500.73
    Chemical carcinogenesis0.77
    Retinol metabolism0.39
    4Abacavir transport and metabolism
    Abacavir transport and metabolism0.50
    Abacavir metabolism0.50
    5Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ADH1A
        Vitamin A and carotenoid metabolism
    Fatty Acid Omega Oxidation


    5/6        Reactome Pathways for ADH1A (see all 6)
        Ethanol oxidation
    Abacavir metabolism
    Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds

    4 PharmGKB Pathways for ADH1A
        Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Celecoxib Pathway, Pharmacokinetics
    Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for ADH1A) (see all 8):
        Glycolysis / Gluconeogenesis
    Fatty acid degradation
    Tyrosine metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450


    ADH1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADH1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for ADH1A (ENSP000002096684) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALDH1A2ENSP000002497504STRING: ENSP00000249750
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process NAS2347582
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0017144drug metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    ADH1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADH1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADH1A

    10/24 HMDB Compounds for ADH1A (see all 24)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-Dihydroxyphenylglycol(3,4-Dihydroxyphenyl)ethylene glycol (see all 9)28822-73-3--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    3a,7a-Dihydroxy-5b-cholestane5beta-Cholestane-3alpha,7alpha-diol (see all 5)3862-26-8--
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--

    6 DrugBank Compounds for ADH1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fomepizole4-methylpyrazole (see all 4)7554-65-6targetinhibitor16946442 16871118 2789998 16790752 19458366 8997246
    EthanolAbsolute Alcohol (see all 34)64-17-5targetagonist18688716 21329681 21166830 19618839
    N-Cyclopentyl-N-Cyclobutylformamide-- --target--17139284 17016423 10592235
    NADHbeta-DPNH (see all 18)606-68-8target--16760478 16897483
    enzymesubstrate16760478 16897483 19583966
    4-Iodopyrazole-- 3469-69-0target--17139284 17016423
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for ADH1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin a 55.1 6 18343808 (1), 15096205 (1), 19011747 (1), 17553814 (1)
    retinoid 51.4 1 17553814 (1)
    acetaldehyde 50 3 16790752 (1), 18304535 (1)
    ethanol 45.1 7 19489444 (2), 16153155 (1), 16790752 (1), 16453102 (1) (see all 6)
    retinoic acid 43.3 5 1996113 (2), 18343808 (1), 7748347 (1), 19011747 (1)

    Search CenterWatch for drugs/clinical trials and news about ADH1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADH1A gene: 
    NM_000667.3  

    Unigene Cluster for ADH1A:

    Alcohol dehydrogenase 1A (class I), alpha polypeptide
    Hs.654433  [show with all ESTs]
    Unigene Representative Sequence: NM_000667
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209668(uc003hur.2) ENST00000503461(uc010ilf.1 uc010ilg.2)
    ENST00000511656

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    Additional mRNA sequence: 

    AK290558.1 AK309597.1 BC074738.2 BC117442.1 BC126306.1 BT019812.1 M12271.1 M12963.1 

    16 DOTS entries:

    DT.121224262  DT.92469055  DT.95158774  DT.100030344  DT.415876  DT.91692319  DT.99980497  DT.100798850 
    DT.121224274  DT.92469032  DT.100001280  DT.100798839  DT.100798841  DT.100798842  DT.101985267  DT.91679459 

    24/475 AceView cDNA sequences (see all 475):

    CB138273 BC074786 CB154296 BG546605 AV709059 AA903791 C00945 AA416884 
    CB147446 AU076586 CB147187 D58197 BM856511 CB267103 CD172162 CB120359 
    BP381206 BU675602 BU687891 BX099744 CB135731 BQ786902 CB135740 AA634614 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADH1A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                      -           -     -     -     -     -               
    SP2:                                            -                                             
    SP3:                                      -                                                   
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ADH1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADH1A expression in normal human tissues (normalized intensities)      ADH1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADH1A Expression
    About this image


    ADH1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Keratocyte (HK)   

    See ADH1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADH1A

    SOURCE GeneReport for Unigene cluster: Hs.654433
        SABiosciences Expression via Pathway-Focused PCR Array including ADH1A: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADH1A gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GGA.455816
    ADH1B6
    class I alcohol dehydrogenase, beta subunit
    69(a)
    65(a)
    1 ↔ many
    possible ortholog
    4(59594470-59604806)
    4(59572341-59590088)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 10)
    --
    72(a)
    70(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    GL343323.1(1237604-1253112)
    GL343323.1(1263142-1274870)
    zebrafish
    (Danio rerio)
    Actinopterygii adh56
    zgc:779386
    (see all 5)
    zgc:77938
    (see all 5)
    61(a)
    56(a)
    (see all 5)
    possible ortholog
    many ↔ many
    (see all 5)
    14(45834134-45846283)
    14(37121611-37132341)
    fruit fly
    (Drosophila melanogaster)
    Insecta Fdh6
    Formaldehyde dehydrogenase
    52(a)
    1 → many
    3R(6696628-6698102)
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.36
    Y50D4C.26
    Protein Y50D4C.2
    49(a)
    31(a)
    many ↔ many
    many ↔ many
    V(911774-916460)
    V(936398-939367)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADH7(YCR105W)4 NADPH-dependent medium chain alcohol dehydrogenase more   --   3(309070-310155) 850469  NP_010030.1 
            Species with no ortholog for ADH1A

    ENSEMBL Gene Tree for ADH1A (if available)
    TreeFam Gene Tree for ADH1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADH1A gene
    ADH1C2  ADH62  ADH42  ADH1B2  ADH52  ADH72  
    6 SIMAP similar genes for ADH1A using alignment to 1 protein entry:     ADH1A_HUMAN:
    ADH1C    ADH1B    ADH7    ADH5    ADH4    ADH6

    ADH1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADH1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659036CNV Deletion23128226
    nsv879656CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103700    OMIM disorders: --

    19 diseases for ADH1A:    About MalaCards
    uterine fibroid    anoxia    alcoholism    substance dependence
    fetal alcohol syndrome    alcoholic liver cirrhosis    alcohol dependence    drug dependence
    liver cirrhosis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    cytochrome p450
    parkinson's disease    tuberculosis    pancreatic cancer    colorectal cancer
    pancreatitis    squamous cell carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADH1A:
    Alcohol dependence

    ADH1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ADH1A
    Human Genome Epidemiology (HuGE) Navigator: ADH1A (24 documents)

    Export disorders for ADH1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADH1A gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with ADH1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of polymorphisms in untranslated regions of t he class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)1, 4, 7 Nishimura F.T....Saijoh K. (2009)
    2. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)1, 4, 9 Luo X....Gelernter J. (2006)
    3. The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. (PubMed id 2347582)1, 2, 9 Yasunami M.... Yoshida A. (1990)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    7. ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (PubMed id 19193628)1, 4 Birley A.J....Whitfield J.B. (2009)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    9. ADH1A variation predisposes to personality traits and substance dependence. (PubMed id 19526455)1, 4 Zuo L....Luo X. (2009)
    10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124 HGNC: 249 AceView: ADH1AandADH1BandADH1C Ensembl:ENSG00000187758 euGenes: HUgn124
    ECgene: ADH1A Kegg: 124 H-InvDB: ADH1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADH1A Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/adh1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADH1A gene:
    Search GeneIP for patents involving ADH1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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