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Aliases for ADH1A Gene

Aliases for ADH1A Gene

  • Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide 2 3 5
  • Alcohol Dehydrogenase Subunit Alpha 3 4
  • EC 1.1.1.1 4 63
  • ADH1 3 4
  • Alcohol Dehydrogenase 1 (Class I), Alpha Polypeptide 3
  • ADH, Alpha Subunit 3
  • Aldehyde Reductase 3
  • EC 1.1.1 63

External Ids for ADH1A Gene

Previous HGNC Symbols for ADH1A Gene

  • ADH1

Previous GeneCards Identifiers for ADH1A Gene

  • GC04M100444
  • GC04M100450
  • GC04M100655
  • GC04M100554
  • GC04M100197
  • GC04M095935

Summaries for ADH1A Gene

Entrez Gene Summary for ADH1A Gene

  • This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

GeneCards Summary for ADH1A Gene

ADH1A (Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ADH1A include Substance Dependence and Methanol Poisoning. Among its related pathways are Abacavir transport and metabolism and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH1A Gene

PharmGKB "VIP" Summary for ADH1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1A Gene

Genomics for ADH1A Gene

Regulatory Elements for ADH1A Gene

Enhancers for ADH1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADH1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ADH1A Gene

Chromosome:
4
Start:
99,276,366 bp from pter
End:
99,291,028 bp from pter
Size:
14,663 bases
Orientation:
Minus strand

Genomic View for ADH1A Gene

Genes around ADH1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1A Gene

Proteins for ADH1A Gene

  • Protein details for ADH1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07327-ADH1A_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1A
    Protein Accession:
    P07327
    Secondary Accessions:
    • A8K3E3
    • Q17R68

    Protein attributes for ADH1A Gene

    Size:
    375 amino acids
    Molecular mass:
    39859 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH1A Gene

neXtProt entry for ADH1A Gene

Proteomics data for ADH1A Gene at MOPED

Post-translational modifications for ADH1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADH1A Gene

Gene Families for ADH1A Gene

Suggested Antigen Peptide Sequences for ADH1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07327

UniProtKB/Swiss-Prot:

ADH1A_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1A: view

Function for ADH1A Gene

Molecular function for ADH1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Enzyme Numbers (IUBMB) for ADH1A Gene

Gene Ontology (GO) - Molecular Function for ADH1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity TAS --
GO:0005515 protein binding IPI 16153155
genes like me logo Genes that share ontologies with ADH1A: view
genes like me logo Genes that share phenotypes with ADH1A: view

Animal Model Products

CRISPR Products

miRNA for ADH1A Gene

miRTarBase miRNAs that target ADH1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH1A Gene

Localization for ADH1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADH1A Gene COMPARTMENTS Subcellular localization image for ADH1A gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
chloroplast 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADH1A Gene

Pathways & Interactions for ADH1A Gene

genes like me logo Genes that share pathways with ADH1A: view

Interacting Proteins for ADH1A Gene

Gene Ontology (GO) - Biological Process for ADH1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process NAS 2347582
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH1A: view

No data available for SIGNOR curated interactions for ADH1A Gene

Drugs & Compounds for ADH1A Gene

(15) Drugs for ADH1A Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fomepizole Approved Pharma inhibitor, Target 3
Ethanol Approved Pharma Enzyme 1924
Vitamin A Approved Nutra 438
Zinc Approved Pharma 2102
Choline Approved Nutra 139

(24) Additional Compounds for ADH1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9

(1) ApexBio Compounds for ADH1A Gene

Compound Action Cas Number
Isovaleramide 541-46-8
genes like me logo Genes that share compounds with ADH1A: view

Transcripts for ADH1A Gene

mRNA/cDNA for ADH1A Gene

Unigene Clusters for ADH1A Gene

Alcohol dehydrogenase 1A (class I), alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ADH1A Gene

GeneLoc Exon Structure for
ADH1A
ECgene alternative splicing isoforms for
ADH1A

Expression for ADH1A Gene

mRNA expression in normal human tissues for ADH1A Gene

mRNA differential expression in normal tissues according to GTEx for ADH1A Gene

This gene is overexpressed in Liver (x45.9).

Protein differential expression in normal tissues from HIPED for ADH1A Gene

This gene is overexpressed in Liver, secretome (49.8) and Liver (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1A Gene



SOURCE GeneReport for Unigene cluster for ADH1A Gene Hs.654433

genes like me logo Genes that share expression patterns with ADH1A: view

Protein tissue co-expression partners for ADH1A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADH1A Gene

Orthologs for ADH1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADH1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH1A 35
  • 99.2 (n)
  • 98.67 (a)
ADH1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adh1 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh1 35
  • 65.69 (n)
  • 66.93 (a)
zebrafish
(Danio rerio)
Actinopterygii adh8a 36
  • 55 (a)
ManyToMany
adh8b 36
  • 52 (a)
ManyToMany
zgc:63568 36
  • 57 (a)
ManyToMany
zgc:77938 36
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 51 (a)
ManyToMany
Y50D4C.2 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 45 (a)
OneToMany
ADH7 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 55 (a)
OneToMany
Species with no ortholog for ADH1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH1A Gene

ENSEMBL:
Gene Tree for ADH1A (if available)
TreeFam:
Gene Tree for ADH1A (if available)

Paralogs for ADH1A Gene

Paralogs for ADH1A Gene

(6) SIMAP similar genes for ADH1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADH1A: view

Variants for ADH1A Gene

Structural Variations from Database of Genomic Variants (DGV) for ADH1A Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294
esv2659036 CNV Deletion 23128226

Variation tolerance for ADH1A Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ADH1A Gene

Disorders for ADH1A Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADH1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
substance dependence
methanol poisoning
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search ADH1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH1A

Genetic Association Database (GAD)
ADH1A
Human Genome Epidemiology (HuGE) Navigator
ADH1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH1A
genes like me logo Genes that share disorders with ADH1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1A Gene

Publications for ADH1A Gene

  1. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PMID: 16685648) Luo X. … Gelernter J. (Am. J. Hum. Genet. 2006) 3 23 48 67
  2. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura F.T. … Saijoh K. (Nihon Arukoru Yakubutsu Igakkai Zasshi 2009) 3 25 26
  3. Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form a biofilm on catheter surfaces through an ethanol-based mechanism. (PMID: 16790752) Mukherjee P.K. … Ghannoum M.A. (Infect. Immun. 2006) 23 25 26
  4. Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration. (PMID: 21166830) Matsumoto M. … Crabb D.W. (Alcohol. Clin. Exp. Res. 2011) 25 26
  5. Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? (PMID: 21329681) HernA!ndez-TobA-as A. … Riveros-Rosas H. (Chem. Biol. Interact. 2011) 25 26

Products for ADH1A Gene

Sources for ADH1A Gene

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