Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRL4 Gene

Aliases for ADGRL4 Gene

  • Adhesion G Protein-Coupled Receptor L4 2 3 5
  • EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 1 3 4
  • EGF, Latrophilin And Seven Transmembrane Domain Containing 1 2 3
  • EGF-TM7-Latrophilin-Related Protein 3 4
  • ELTD1 3 4
  • ETL 3 4
  • ETL Protein 4
  • KPG_003 3

External Ids for ADGRL4 Gene

Previous HGNC Symbols for ADGRL4 Gene

  • ELTD1

Summaries for ADGRL4 Gene

GeneCards Summary for ADGRL4 Gene

ADGRL4 (Adhesion G Protein-Coupled Receptor L4) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL3.

UniProtKB/Swiss-Prot for ADGRL4 Gene

  • Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Gene Wiki entry for ADGRL4 Gene

Additional gene information for ADGRL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL4 Gene

Genomics for ADGRL4 Gene

Regulatory Elements for ADGRL4 Gene

Enhancers for ADGRL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H079075 1.4 VISTA Ensembl ENCODE 10.9 -72.7 -72746 7 STAT1 JUN ZNF140 OSR2 JUND MAFF FOS FOXP2 MAFK TRIM28 ADGRL4 GC01M079074 GC01P079122
GH01H079192 0.9 Ensembl ENCODE 15.1 -186.4 -186432 1 MAX CEBPB JUNB DPF2 BATF EP300 ZNF217 JUND POLR2A IKZF1 ADGRL4 GC01P079122 LOC105378810
GH01H079040 0.9 FANTOM5 Ensembl 11.5 -34.0 -33991 0 ZBED1 JUNB FEZF1 BATF OSR2 JUND BCL11A ETV6 ATF7 RUNX3 ADGRL4 IFI44 PSAT1P3
GH01H079187 0.6 ENCODE 15.6 -181.6 -181642 1 ELK4 TBP SMARCC1 JUN BATF EP300 JUND POLR2A FOS ADGRL4 GC01P079122 LOC105378810
GH01H079042 0.7 ENCODE 11.5 -35.5 -35461 0 PKNOX1 JUN BACH1 BATF FOS ETV6 NFE2 RUNX3 MAFK CREM ADGRL4 PSAT1P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRL4 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008875 409 1200 POLR2A JUN CTBP2

Genomic Location for ADGRL4 Gene

Chromosome:
1
Start:
78,889,764 bp from pter
End:
79,006,810 bp from pter
Size:
117,047 bases
Orientation:
Minus strand

Genomic View for ADGRL4 Gene

Genes around ADGRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL4 Gene

Proteins for ADGRL4 Gene

  • Protein details for ADGRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBW9-AGRL4_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L4
    Protein Accession:
    Q9HBW9
    Secondary Accessions:
    • B1AR71
    • Q5KU34

    Protein attributes for ADGRL4 Gene

    Size:
    690 amino acids
    Molecular mass:
    77811 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
    SequenceCaution:
    • Sequence=AAG33021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25721.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRL4 Gene

Post-translational modifications for ADGRL4 Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn21, Asn64, Asn74, posLast=127127, Asn177, Asn188, posLast=249249, Asn381, and posLast=395395
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRL4 Gene

Domains & Families for ADGRL4 Gene

Gene Families for ADGRL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ADGRL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBW9

UniProtKB/Swiss-Prot:

AGRL4_HUMAN :
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL4: view

Function for ADGRL4 Gene

Molecular function for ADGRL4 Gene

UniProtKB/Swiss-Prot Function:
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in tumor endothelial cells. Up-regulated by DLL4.

Phenotypes From GWAS Catalog for ADGRL4 Gene

Gene Ontology (GO) - Molecular Function for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0005509 calcium ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ADGRL4: view
genes like me logo Genes that share phenotypes with ADGRL4: view

Animal Models for ADGRL4 Gene

MGI Knock Outs for ADGRL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRL4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRL4 Gene

Localization for ADGRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
GO:0031410 cytoplasmic vesicle ISS,IEA --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRL4 Gene

Pathways & Interactions for ADGRL4 Gene

SuperPathways for ADGRL4 Gene

SuperPathway Contained pathways
1 GPCRs, Class B Secretin-like
genes like me logo Genes that share pathways with ADGRL4: view

Pathways by source for ADGRL4 Gene

1 BioSystems pathway for ADGRL4 Gene

Interacting Proteins for ADGRL4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359778%0d%0a9606.ENSP00000429430%0d%0a9606.ENSP00000403954%0d%0a9606.ENSP00000385276%0d%0a9606.ENSP00000265131%0d%0a9606.ENSP00000239462%0d%0a
Selected Interacting proteins: Q9HBW9-AGRL4_HUMAN ENSP00000359778 for ADGRL4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for SIGNOR curated interactions for ADGRL4 Gene

Drugs & Compounds for ADGRL4 Gene

No Compound Related Data Available

Transcripts for ADGRL4 Gene

mRNA/cDNA for ADGRL4 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL4 Gene

No ASD Table

Relevant External Links for ADGRL4 Gene

GeneLoc Exon Structure for
ADGRL4
ECgene alternative splicing isoforms for
ADGRL4

Expression for ADGRL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRL4 Gene

Protein differential expression in normal tissues from HIPED for ADGRL4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRL4 Gene



Protein tissue co-expression partners for ADGRL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRL4 Gene:

ADGRL4

mRNA Expression by UniProt/SwissProt for ADGRL4 Gene:

Q9HBW9-AGRL4_HUMAN
Tissue specificity: Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.

Evidence on tissue expression from TISSUES for ADGRL4 Gene

  • Bone marrow(4)
  • Pancreas(4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ADGRL4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRL4 Gene

Orthologs for ADGRL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELTD1 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia ELTD1 33 34
  • 90.14 (n)
cow
(Bos Taurus)
Mammalia ELTD1 33 34
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia Eltd1 33 34
  • 78.68 (n)
Adgrl4 16
rat
(Rattus norvegicus)
Mammalia Eltd1 33
  • 77.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ELTD1 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELTD1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELTD1 33 34
  • 71.4 (n)
lizard
(Anolis carolinensis)
Reptilia ELTD1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731473 33
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68819 33
zebrafish
(Danio rerio)
Actinopterygii eltd1 33 34
  • 60.25 (n)
worm
(Caenorhabditis elegans)
Secernentea lat-1 34
  • 18 (a)
OneToMany
Species where no ortholog for ADGRL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL4 Gene

ENSEMBL:
Gene Tree for ADGRL4 (if available)
TreeFam:
Gene Tree for ADGRL4 (if available)

Paralogs for ADGRL4 Gene

Paralogs for ADGRL4 Gene

genes like me logo Genes that share paralogs with ADGRL4: view

Variants for ADGRL4 Gene

Sequence variations from dbSNP and Humsavar for ADGRL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010971 -- 78,901,233(+) CTTCA(A/T)AGCTT intron-variant
rs1000083760 -- 79,001,423(+) ACAAA(-/AAAGAAAG)AAAGA intron-variant
rs1000093521 -- 78,980,527(+) CTTAA(C/T)ATTGT intron-variant
rs1000097858 -- 78,932,948(+) AACAA(A/T)AAAAG intron-variant
rs1000113063 -- 79,000,908(+) GTTTG(A/C)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRL4 Gene

Variant ID Type Subtype PubMed ID
dgv331n54 CNV loss 21841781
dgv332n54 CNV loss 21841781
dgv333n54 CNV loss 21841781
esv1001130 CNV deletion 20482838
esv2156352 CNV deletion 18987734
esv21924 CNV loss 19812545
esv2551231 CNV deletion 19546169
esv2661629 CNV deletion 23128226
esv2750229 CNV deletion 23290073
esv2750240 CNV deletion 23290073
esv2750252 CNV deletion 23290073
esv3564571 CNV deletion 23714750
esv3586563 CNV loss 21293372
esv3586564 CNV loss 21293372
esv4207 CNV loss 18987735
esv9047 CNV loss 19470904
nsv1001291 CNV loss 25217958
nsv1010441 CNV loss 25217958
nsv1077959 CNV deletion 25765185
nsv1122370 CNV deletion 24896259
nsv1147665 CNV deletion 26484159
nsv462139 CNV loss 19166990
nsv470720 CNV loss 18288195
nsv526221 CNV loss 19592680
nsv528328 CNV loss 19592680
nsv546619 CNV loss 21841781
nsv546621 CNV loss 21841781
nsv546623 CNV loss 21841781
nsv546629 CNV loss 21841781
nsv957236 CNV deletion 24416366

Variation tolerance for ADGRL4 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL4 Gene

Disorders for ADGRL4 Gene

Relevant External Links for ADGRL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL4

No disorders were found for ADGRL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRL4 Gene

Publications for ADGRL4 Gene

  1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. (PMID: 11050079) Nechiporuk T … Keating MT (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 60
  3. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. (PMID: 23871637) Masiero M … Buffa FM (Cancer cell 2013) 3 4 60
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ADGRL4 Gene

Sources for ADGRL4 Gene

Content
Loading form....