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Aliases for ADGRL4 Gene

Aliases for ADGRL4 Gene

  • Adhesion G Protein-Coupled Receptor L4 2 3
  • EGF, Latrophilin And Seven Transmembrane Domain Containing 1 2 3
  • EGF-TM7-Latrophilin-Related Protein 3 4
  • ELTD1 3 4
  • ETL 3 4
  • EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 1 3
  • ETL Protein 4
  • KPG_003 3

External Ids for ADGRL4 Gene

Previous HGNC Symbols for ADGRL4 Gene

  • ELTD1

Summaries for ADGRL4 Gene

GeneCards Summary for ADGRL4 Gene

ADGRL4 (Adhesion G Protein-Coupled Receptor L4) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL4 Gene

  • Could be involved in cardiac development

Gene Wiki entry for ADGRL4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL4 Gene

Genomics for ADGRL4 Gene

Genomic Location for ADGRL4 Gene

78,889,764 bp from pter
79,006,810 bp from pter
117,047 bases
Minus strand

Genomic View for ADGRL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL4 Gene

No data available for Regulatory Elements for ADGRL4 Gene

Proteins for ADGRL4 Gene

  • Protein details for ADGRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EGF, latrophilin and seven transmembrane domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B1AR71
    • Q5KU34

    Protein attributes for ADGRL4 Gene

    690 amino acids
    Molecular mass:
    77811 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity).
    • Sequence=AAG33021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25721.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRL4 Gene

Proteomics data for ADGRL4 Gene at MOPED

Post-translational modifications for ADGRL4 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRL4 Gene

Domains for ADGRL4 Gene

Gene Families for ADGRL4 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Q9HBW9
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Contains 2 EGF-like domains.
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRL4: view

No data available for Suggested Antigen Peptide Sequences for ADGRL4 Gene

Function for ADGRL4 Gene

Molecular function for ADGRL4 Gene

UniProtKB/Swiss-Prot Function:
Could be involved in cardiac development

Gene Ontology (GO) - Molecular Function for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ADGRL4: view

Phenotypes for ADGRL4 Gene

MGI mutant phenotypes for ADGRL4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ADGRL4: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRL4 Gene

Localization for ADGRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL4 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for Subcellular locations from COMPARTMENTS for ADGRL4 Gene

Pathways for ADGRL4 Gene

SuperPathways for ADGRL4 Gene

genes like me logo Genes that share pathways with ADGRL4: view

Pathways by source for ADGRL4 Gene

1 BioSystems pathway for ADGRL4 Gene

Interacting Proteins for ADGRL4 Gene

Gene Ontology (GO) - Biological Process for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRL4: view

Transcripts for ADGRL4 Gene

mRNA/cDNA for ADGRL4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRL4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL4 Gene

No ASD Table

Relevant External Links for ADGRL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRL4 Gene

mRNA expression in normal human tissues for ADGRL4 Gene

Protein differential expression in normal tissues for ADGRL4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRL4 Gene

mRNA Expression by UniProt/SwissProt for ADGRL4 Gene

Tissue specificity: Mainly expressed in smooth muscle
genes like me logo Genes that share expressions with ADGRL4: view

Expression partners for ADGRL4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADGRL4 Gene

Orthologs for ADGRL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ELTD1 35
  • 89.4 (n)
  • 88.1 (a)
ELTD1 36
  • 88 (a)
(Canis familiaris)
Mammalia ELTD1 35
  • 90.14 (n)
  • 89.86 (a)
ELTD1 36
  • 90 (a)
(Mus musculus)
Mammalia Eltd1 35
  • 78.68 (n)
  • 78.05 (a)
Eltd1 16
Eltd1 36
  • 74 (a)
(Pan troglodytes)
Mammalia ELTD1 35
  • 99.18 (n)
  • 98.7 (a)
ELTD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Eltd1 35
  • 77.34 (n)
  • 77.15 (a)
(Monodelphis domestica)
Mammalia ELTD1 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ELTD1 36
  • 67 (a)
(Gallus gallus)
Aves ELTD1 35
  • 71.4 (n)
  • 68.23 (a)
ELTD1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia ELTD1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731473 35
  • 67.2 (n)
  • 65.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68819 35
(Danio rerio)
Actinopterygii eltd1 35
  • 60.25 (n)
  • 56.12 (a)
eltd1 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 18 (a)
Species with no ortholog for ADGRL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL4 Gene

Gene Tree for ADGRL4 (if available)
Gene Tree for ADGRL4 (if available)

Paralogs for ADGRL4 Gene

genes like me logo Genes that share paralogs with ADGRL4: view

Variants for ADGRL4 Gene

Sequence variations from dbSNP and Humsavar for ADGRL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs723898 -- 78,946,203(-) AACAT(A/G)TTCAA intron-variant
rs971064 -- 78,912,307(-) TCAAG(C/T)TTTTC intron-variant
rs973313 -- 78,938,930(-) TTTTT(A/G)TGTAA intron-variant
rs973314 -- 78,938,768(-) TATGA(C/T)TGAAA intron-variant
rs973315 -- 78,938,757(-) ATGTG(A/T)ATCTC intron-variant

Relevant External Links for ADGRL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRL4 Gene

Disorders for ADGRL4 Gene

No disorders were found for ADGRL4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ADGRL4 Gene

Publications for ADGRL4 Gene

  1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. (PMID: 11050079) Nechiporuk T. … Keating M.T. (J. Biol. Chem. 2001) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4

Products for ADGRL4 Gene

Sources for ADGRL4 Gene

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