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Aliases for ADGRL4 Gene

Aliases for ADGRL4 Gene

  • Adhesion G Protein-Coupled Receptor L4 2 3 5
  • EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 1 3 4
  • EGF, Latrophilin And Seven Transmembrane Domain Containing 1 2 3
  • EGF-TM7-Latrophilin-Related Protein 3 4
  • ELTD1 3 4
  • ETL 3 4
  • ETL Protein 4
  • KPG_003 3

External Ids for ADGRL4 Gene

Previous HGNC Symbols for ADGRL4 Gene

  • ELTD1

Summaries for ADGRL4 Gene

GeneCards Summary for ADGRL4 Gene

ADGRL4 (Adhesion G Protein-Coupled Receptor L4) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL4 Gene

  • Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Gene Wiki entry for ADGRL4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL4 Gene

Genomics for ADGRL4 Gene

Regulatory Elements for ADGRL4 Gene

Enhancers for ADGRL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRL4 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRL4 Gene

Chromosome:
1
Start:
78,889,764 bp from pter
End:
79,006,810 bp from pter
Size:
117,047 bases
Orientation:
Minus strand

Genomic View for ADGRL4 Gene

Genes around ADGRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL4 Gene

Proteins for ADGRL4 Gene

  • Protein details for ADGRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBW9-AGRL4_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L4
    Protein Accession:
    Q9HBW9
    Secondary Accessions:
    • B1AR71
    • Q5KU34

    Protein attributes for ADGRL4 Gene

    Size:
    690 amino acids
    Molecular mass:
    77811 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
    SequenceCaution:
    • Sequence=AAG33021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25721.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRL4 Gene

Proteomics data for ADGRL4 Gene at MOPED

Post-translational modifications for ADGRL4 Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 21, Asn 64, Asn 74, Asn 127, Asn 177, Asn 188, Asn 249, Asn 381, and Asn 395
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRL4 Gene

Domains & Families for ADGRL4 Gene

Gene Families for ADGRL4 Gene

Suggested Antigen Peptide Sequences for ADGRL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBW9

UniProtKB/Swiss-Prot:

AGRL4_HUMAN :
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Contains 2 EGF-like domains.
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL4: view

Function for ADGRL4 Gene

Molecular function for ADGRL4 Gene

UniProtKB/Swiss-Prot Function:
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in tumor endothelial cells. Up-regulated by DLL4.

Gene Ontology (GO) - Molecular Function for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ADGRL4: view
genes like me logo Genes that share phenotypes with ADGRL4: view

Animal Models for ADGRL4 Gene

MGI Knock Outs for ADGRL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRL4 Gene

Localization for ADGRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL4 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRL4: view

No data available for Subcellular locations from COMPARTMENTS for ADGRL4 Gene

Pathways & Interactions for ADGRL4 Gene

SuperPathways for ADGRL4 Gene

genes like me logo Genes that share pathways with ADGRL4: view

Pathways by source for ADGRL4 Gene

1 BioSystems pathway for ADGRL4 Gene

Interacting Proteins for ADGRL4 Gene

Gene Ontology (GO) - Biological Process for ADGRL4 Gene

None

No data available for SIGNOR curated interactions for ADGRL4 Gene

Drugs & Compounds for ADGRL4 Gene

No Compound Related Data Available

Transcripts for ADGRL4 Gene

mRNA/cDNA for ADGRL4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL4 Gene

No ASD Table

Relevant External Links for ADGRL4 Gene

GeneLoc Exon Structure for
ADGRL4
ECgene alternative splicing isoforms for
ADGRL4

Expression for ADGRL4 Gene

mRNA expression in normal human tissues for ADGRL4 Gene

Protein differential expression in normal tissues from HIPED for ADGRL4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRL4 Gene



mRNA Expression by UniProt/SwissProt for ADGRL4 Gene

Q9HBW9-AGRL4_HUMAN
Tissue specificity: Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.
genes like me logo Genes that share expression patterns with ADGRL4: view

Protein tissue co-expression partners for ADGRL4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRL4 Gene

Orthologs for ADGRL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELTD1 35
  • 89.4 (n)
  • 88.1 (a)
ELTD1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELTD1 35
  • 90.14 (n)
  • 89.86 (a)
ELTD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eltd1 35
  • 78.68 (n)
  • 78.05 (a)
Adgrl4 16
Eltd1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELTD1 35
  • 99.18 (n)
  • 98.7 (a)
ELTD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eltd1 35
  • 77.34 (n)
  • 77.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ELTD1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELTD1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELTD1 35
  • 71.4 (n)
  • 68.23 (a)
ELTD1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELTD1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731473 35
  • 67.2 (n)
  • 65.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68819 35
zebrafish
(Danio rerio)
Actinopterygii eltd1 35
  • 60.25 (n)
  • 56.12 (a)
eltd1 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 18 (a)
OneToMany
Species with no ortholog for ADGRL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL4 Gene

ENSEMBL:
Gene Tree for ADGRL4 (if available)
TreeFam:
Gene Tree for ADGRL4 (if available)

Paralogs for ADGRL4 Gene

genes like me logo Genes that share paralogs with ADGRL4: view

Variants for ADGRL4 Gene

Sequence variations from dbSNP and Humsavar for ADGRL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12754818 - 78,927,071(+) ATATA(A/C)AAATG reference, missense
rs1968956 - 78,893,142(+) GCAGT(G/T)TGACG reference, missense
rs2275902 - 78,891,675(+) CGAGG(C/G)CTCCT reference, missense
rs723898 -- 78,946,203(-) AACAT(A/G)TTCAA intron-variant
rs971064 -- 78,912,307(-) TCAAG(C/T)TTTTC intron-variant

Variation tolerance for ADGRL4 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRL4 Gene

Disorders for ADGRL4 Gene

Relevant External Links for ADGRL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL4

No disorders were found for ADGRL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRL4 Gene

Publications for ADGRL4 Gene

  1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. (PMID: 11050079) Nechiporuk T. … Keating M.T. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme. (PMID: 26449464) Dai S. … Cao Y. (Biochem. Biophys. Res. Commun. 2015) 3
  4. ELTD1, a potential new biomarker for gliomas. (PMID: 23096411) Towner R.A. … Wren J.D. (Neurosurgery 2013) 3
  5. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3

Products for ADGRL4 Gene

Sources for ADGRL4 Gene

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