Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRL3 Gene

Aliases for ADGRL3 Gene

  • Adhesion G Protein-Coupled Receptor L3 2 3 5
  • Calcium-Independent Alpha-Latrotoxin Receptor 3 3 4
  • Latrophilin-3 3 4
  • CIRL-3 3 4
  • LPHN3 3 4
  • LEC3 3 4
  • Latrophilin Homolog 3 (Cow) 3
  • Latrophilin 3 2
  • Lectomedin 3 3
  • Lectomedin-3 4
  • KIAA0768 4
  • CIRL3 3
  • CL3 3

External Ids for ADGRL3 Gene

Previous HGNC Symbols for ADGRL3 Gene

  • LPHN3

Summaries for ADGRL3 Gene

Entrez Gene Summary for ADGRL3 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRL3 Gene

ADGRL3 (Adhesion G Protein-Coupled Receptor L3) is a Protein Coding gene. Diseases associated with ADGRL3 include attention deficit-hyperactivity disorder. Among its related pathways are GPCRs, Class B Secretin-like and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL3 Gene

  • Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Gene Wiki entry for ADGRL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL3 Gene

Genomics for ADGRL3 Gene

Regulatory Elements for ADGRL3 Gene

Enhancers for ADGRL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRL3 Gene

Chromosome:
4
Start:
61,201,258 bp from pter
End:
62,078,335 bp from pter
Size:
877,078 bases
Orientation:
Plus strand

Genomic View for ADGRL3 Gene

Genes around ADGRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL3 Gene

Proteins for ADGRL3 Gene

  • Protein details for ADGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAR2-AGRL3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L3
    Protein Accession:
    Q9HAR2
    Secondary Accessions:
    • E9PE04
    • O94867
    • Q9NWK5

    Protein attributes for ADGRL3 Gene

    Size:
    1447 amino acids
    Molecular mass:
    161812 Da
    Quaternary structure:
    • Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself (PubMed:26235030). Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself (PubMed:26235030). Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain). Interacts (via extracellular domain) with TENM1. Interacts (via extracellular domain) with TENM3 (By similarity).
    SequenceCaution:
    • Sequence=BAA91375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRL3 Gene

    Alternative splice isoforms for ADGRL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRL3 Gene

Proteomics data for ADGRL3 Gene at MOPED

Post-translational modifications for ADGRL3 Gene

  • O-glycosylated (major) and N-glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRL3 Gene

Domains & Families for ADGRL3 Gene

Gene Families for ADGRL3 Gene

Suggested Antigen Peptide Sequences for ADGRL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAR2

UniProtKB/Swiss-Prot:

AGRL3_HUMAN :
  • The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TENM1 (By similarity).
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TENM1 (By similarity).
  • Contains 1 GPS domain.
  • Contains 1 olfactomedin-like domain.
  • Contains 1 SUEL-type lectin domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRL3: view

Function for ADGRL3 Gene

Molecular function for ADGRL3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Gene Ontology (GO) - Molecular Function for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRL3: view
genes like me logo Genes that share phenotypes with ADGRL3: view

Animal Model Products

miRNA for ADGRL3 Gene

miRTarBase miRNAs that target ADGRL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRL3 Gene

Localization for ADGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL3 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction.

Gene Ontology (GO) - Cellular Components for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRL3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRL3 Gene

Pathways & Interactions for ADGRL3 Gene

genes like me logo Genes that share pathways with ADGRL3: view

Pathways by source for ADGRL3 Gene

2 BioSystems pathways for ADGRL3 Gene

Interacting Proteins for ADGRL3 Gene

Gene Ontology (GO) - Biological Process for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration ISS --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with ADGRL3: view

No data available for SIGNOR curated interactions for ADGRL3 Gene

Drugs & Compounds for ADGRL3 Gene

(1) Drugs for ADGRL3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 367
genes like me logo Genes that share compounds with ADGRL3: view

Transcripts for ADGRL3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL3 Gene

No ASD Table

Relevant External Links for ADGRL3 Gene

GeneLoc Exon Structure for
ADGRL3
ECgene alternative splicing isoforms for
ADGRL3

Expression for ADGRL3 Gene

mRNA expression in normal human tissues for ADGRL3 Gene

Protein differential expression in normal tissues from HIPED for ADGRL3 Gene

This gene is overexpressed in Cerebrospinal fluid (24.2), Serum (15.5), and Fetal Brain (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRL3 Gene



genes like me logo Genes that share expression patterns with ADGRL3: view

Protein tissue co-expression partners for ADGRL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRL3 Gene

Orthologs for ADGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPHN3 35
  • 94.26 (n)
  • 98.35 (a)
LPHN3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC482166 35
  • 94.39 (n)
  • 98.69 (a)
LPHN3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn3 35
  • 89.97 (n)
  • 97.18 (a)
Adgrl3 16
Lphn3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPHN3 35
  • 99.71 (n)
  • 100 (a)
LPHN3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lphn3 35
  • 89.46 (n)
  • 96.9 (a)
oppossum
(Monodelphis domestica)
Mammalia LPHN3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPHN3 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPHN3 35
  • 82.77 (n)
  • 92.46 (a)
LPHN3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPHN3 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498069 35
  • 76.18 (n)
  • 83.91 (a)
zebrafish
(Danio rerio)
Actinopterygii lphn3.1 35
  • 68.33 (n)
  • 76.76 (a)
wufj36g07 35
lphn3.1 36
  • 71 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 29 (a)
OneToMany
Species with no ortholog for ADGRL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL3 Gene

ENSEMBL:
Gene Tree for ADGRL3 (if available)
TreeFam:
Gene Tree for ADGRL3 (if available)

Paralogs for ADGRL3 Gene

genes like me logo Genes that share paralogs with ADGRL3: view

Variants for ADGRL3 Gene

Sequence variations from dbSNP and Humsavar for ADGRL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35106420 - 61,892,773(+) AAACC(A/G)GAGTA reference, missense
VAR_064477 -
VAR_064478 -
VAR_064479 -
rs170842 -- 61,496,813(-) CAAGC(A/G/T)CCCAC intron-variant, upstream-variant-2KB

Variation tolerance for ADGRL3 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL3 Gene

HapMap Linkage Disequilibrium report
ADGRL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRL3 Gene

Disorders for ADGRL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL3
genes like me logo Genes that share disorders with ADGRL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRL3 Gene

Publications for ADGRL3 Gene

  1. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. (PMID: 26235030) Lu Y.C. … Arac D. (Structure 2015) 3 4 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3
  4. LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study. (PMID: 25989180) Bruxel E.M. … Hutz M.H. (Genes Brain Behav. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ADGRL3 Gene

Sources for ADGRL3 Gene

Content