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Aliases for ADGRL3 Gene

Aliases for ADGRL3 Gene

  • Adhesion G Protein-Coupled Receptor L3 2 3 5
  • Calcium-Independent Alpha-Latrotoxin Receptor 3 3 4
  • Latrophilin-3 3 4
  • CIRL-3 3 4
  • LPHN3 3 4
  • LEC3 3 4
  • Latrophilin Homolog 3 (Cow) 3
  • Latrophilin 3 2
  • Lectomedin 3 3
  • Lectomedin-3 4
  • KIAA0768 4
  • CIRL3 3
  • CL3 3

External Ids for ADGRL3 Gene

Previous HGNC Symbols for ADGRL3 Gene

  • LPHN3

Summaries for ADGRL3 Gene

Entrez Gene Summary for ADGRL3 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRL3 Gene

ADGRL3 (Adhesion G Protein-Coupled Receptor L3) is a Protein Coding gene. Diseases associated with ADGRL3 include Attention Deficit-Hyperactivity Disorder. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL2.

UniProtKB/Swiss-Prot for ADGRL3 Gene

  • Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Gene Wiki entry for ADGRL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL3 Gene

Genomics for ADGRL3 Gene

Regulatory Elements for ADGRL3 Gene

Enhancers for ADGRL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G060682 1.1 FANTOM5 Ensembl ENCODE 15.6 -517.8 -517793 2.5 JUND FOS CEBPG MAFK ADGRL3 LINC02496 GC04P060583
GH04G061199 1.2 FANTOM5 ENCODE 6.1 +1.0 960 4.8 ZSCAN4 ZNF366 SCRT2 EGR2 ZNF263 SP3 ZEB2 ZNF398 ZFP69B SMARCA4 ADGRL3 RPL17P19
GH04G060723 1 FANTOM5 Ensembl ENCODE 7.2 -476.6 -476557 2.2 CTCF JUND FOS RAD21 ADGRL3 LINC02496 GC04P060583
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRL3 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168783 -458 1601 MXI1 SUZ12 RBBP5 FOXM1 ZNF366 POLR2A EZH2 EGR2 ZNF263 MAZ

Genomic Location for ADGRL3 Gene

Chromosome:
4
Start:
61,201,258 bp from pter
End:
62,078,335 bp from pter
Size:
877,078 bases
Orientation:
Plus strand

Genomic View for ADGRL3 Gene

Genes around ADGRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL3 Gene

Proteins for ADGRL3 Gene

  • Protein details for ADGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAR2-AGRL3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L3
    Protein Accession:
    Q9HAR2
    Secondary Accessions:
    • E9PE04
    • O94867
    • Q9NWK5

    Protein attributes for ADGRL3 Gene

    Size:
    1447 amino acids
    Molecular mass:
    161812 Da
    Quaternary structure:
    • Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself (PubMed:26235030). Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself (PubMed:26235030). Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain). Interacts (via extracellular domain) with TENM1. Interacts (via extracellular domain) with TENM3 (By similarity).
    SequenceCaution:
    • Sequence=BAA91375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRL3 Gene

    Alternative splice isoforms for ADGRL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRL3 Gene

Post-translational modifications for ADGRL3 Gene

  • O-glycosylated (major) and N-glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for ADGRL3 (Latrophilin 3/LPHN3)
  • Cloud-Clone Corp. Antibodies for ADGRL3

No data available for DME Specific Peptides for ADGRL3 Gene

Domains & Families for ADGRL3 Gene

Gene Families for ADGRL3 Gene

Suggested Antigen Peptide Sequences for ADGRL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAR2

UniProtKB/Swiss-Prot:

AGRL3_HUMAN :
  • The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TENM1 (By similarity).
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TENM1 (By similarity).
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRL3: view

Function for ADGRL3 Gene

Molecular function for ADGRL3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.

Gene Ontology (GO) - Molecular Function for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,NAS 10994649
GO:0005509 calcium ion binding IDA 26235030
GO:0005515 protein binding IPI 26235030
genes like me logo Genes that share ontologies with ADGRL3: view
genes like me logo Genes that share phenotypes with ADGRL3: view

Animal Models for ADGRL3 Gene

MGI Knock Outs for ADGRL3:

Animal Model Products

miRNA for ADGRL3 Gene

miRTarBase miRNAs that target ADGRL3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL3 Gene

Localization for ADGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL3 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 26235030
GO:0005911 cell-cell junction ISS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10994649
genes like me logo Genes that share ontologies with ADGRL3: view

Pathways & Interactions for ADGRL3 Gene

genes like me logo Genes that share pathways with ADGRL3: view

Pathways by source for ADGRL3 Gene

2 BioSystems pathways for ADGRL3 Gene

Gene Ontology (GO) - Biological Process for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration ISS --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 10994649
GO:0007416 synapse assembly ISS,IEA --
genes like me logo Genes that share ontologies with ADGRL3: view

No data available for SIGNOR curated interactions for ADGRL3 Gene

Drugs & Compounds for ADGRL3 Gene

(1) Drugs for ADGRL3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 375
genes like me logo Genes that share compounds with ADGRL3: view

Transcripts for ADGRL3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL3 Gene

No ASD Table

Relevant External Links for ADGRL3 Gene

GeneLoc Exon Structure for
ADGRL3
ECgene alternative splicing isoforms for
ADGRL3

Expression for ADGRL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRL3 Gene

Protein differential expression in normal tissues from HIPED for ADGRL3 Gene

This gene is overexpressed in Cerebrospinal fluid (24.2), Serum (15.5), and Fetal Brain (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRL3 Gene



Protein tissue co-expression partners for ADGRL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRL3 Gene:

ADGRL3

Evidence on tissue expression from TISSUES for ADGRL3 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ADGRL3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRL3 Gene

Orthologs for ADGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPHN3 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia LPHN3 35
  • 98 (a)
OneToOne
LOC482166 34
  • 94.39 (n)
oppossum
(Monodelphis domestica)
Mammalia LPHN3 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPHN3 35 34
  • 94.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn3 34 35
  • 89.97 (n)
Adgrl3 16
rat
(Rattus norvegicus)
Mammalia Lphn3 34
  • 89.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LPHN3 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPHN3 34 35
  • 82.77 (n)
lizard
(Anolis carolinensis)
Reptilia LPHN3 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498069 34
  • 76.18 (n)
zebrafish
(Danio rerio)
Actinopterygii lphn3.1 34 35
  • 68.33 (n)
wufj36g07 34
worm
(Caenorhabditis elegans)
Secernentea lat-1 35
  • 29 (a)
OneToMany
Species where no ortholog for ADGRL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL3 Gene

ENSEMBL:
Gene Tree for ADGRL3 (if available)
TreeFam:
Gene Tree for ADGRL3 (if available)

Paralogs for ADGRL3 Gene

genes like me logo Genes that share paralogs with ADGRL3: view

Variants for ADGRL3 Gene

Sequence variations from dbSNP and Humsavar for ADGRL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000001475 -- 61,679,454(+) TAGAC(C/T)TTCCC intron-variant
rs1000003077 -- 61,830,433(+) AGAAC(A/C)TTTTT intron-variant
rs1000007390 -- 61,695,360(+) TTGTA(C/T)ATTAT intron-variant
rs1000013350 -- 61,313,321(+) ACATG(C/G)CACTA intron-variant
rs10000153 -- 61,338,342(+) TATTC(A/C)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRL3 Gene

Variant ID Type Subtype PubMed ID
esv1721979 CNV deletion 17803354
esv2671240 CNV deletion 23128226
esv26839 CNV gain 19812545
esv2727704 CNV deletion 23290073
esv3051726 CNV deletion 24192839
esv3304320 CNV mobile element insertion 20981092
esv3304520 CNV mobile element insertion 20981092
esv3306442 CNV mobile element insertion 20981092
esv3309141 CNV mobile element insertion 20981092
esv3323185 CNV insertion 20981092
esv3569450 CNV loss 25503493
esv3600689 CNV loss 21293372
esv3600690 CNV loss 21293372
esv3600691 CNV loss 21293372
esv3600693 CNV loss 21293372
esv3600695 CNV loss 21293372
esv3893929 CNV loss 25118596
nsv1012574 CNV gain 25217958
nsv1074175 CNV deletion 25765185
nsv1139258 CNV deletion 24896259
nsv1143287 CNV deletion 24896259
nsv475919 CNV novel sequence insertion 20440878
nsv507170 OTHER sequence alteration 20534489
nsv516728 CNV loss 19592680
nsv594328 CNV loss 21841781
nsv594329 CNV loss 21841781
nsv594330 CNV gain 21841781
nsv594331 CNV gain 21841781
nsv821451 CNV deletion 20802225
nsv829949 CNV loss 17160897
nsv955673 CNV deletion 24416366
nsv980206 CNV duplication 23825009
nsv999023 CNV loss 25217958

Variation tolerance for ADGRL3 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL3 Gene

Disorders for ADGRL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRL3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL3
genes like me logo Genes that share disorders with ADGRL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRL3 Gene

Publications for ADGRL3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 64
  2. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. (PMID: 26235030) Lu Y.C. … Arac D. (Structure 2015) 3 4 64
  3. Screening of human LPHN3 for variants with a potential impact on ADHD susceptibility. (PMID: 21184580) DomenAc S. … Muenke M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3 64

Products for ADGRL3 Gene

Sources for ADGRL3 Gene

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