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Aliases for ADGRL2 Gene

Aliases for ADGRL2 Gene

  • Adhesion G Protein-Coupled Receptor L2 2 3 5
  • Calcium-Independent Alpha-Latrotoxin Receptor 2 3 4
  • Latrophilin Homolog 1 3 4
  • Latrophilin-2 3 4
  • Lectomedin-1 3 4
  • LPHH1 3 4
  • LPHN2 3 4
  • LEC1 3 4
  • Latrophilin 1 2
  • Latrophilin 2 2
  • KIAA0786 4
  • CIRL-2 4
  • CIRL2 3
  • CL2 3

External Ids for ADGRL2 Gene

Previous HGNC Symbols for ADGRL2 Gene

  • LPHH1
  • LPHN2

Summaries for ADGRL2 Gene

Entrez Gene Summary for ADGRL2 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ADGRL2 Gene

ADGRL2 (Adhesion G Protein-Coupled Receptor L2) is a Protein Coding gene. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL1.

UniProtKB/Swiss-Prot for ADGRL2 Gene

  • Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.

Gene Wiki entry for ADGRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL2 Gene

Genomics for ADGRL2 Gene

Regulatory Elements for ADGRL2 Gene

Enhancers for ADGRL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F081799 1.4 FANTOM5 ENCODE 7.3 +496.0 495993 5.5 PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 KLF7 FOS ZNF263 ADGRL2 GC01M081803 ST13P20
GH01F081406 0.8 Ensembl ENCODE 5.7 +101.1 101067 2.0 SMARCA4 SCRT2 ZNF843 ATF2 ADGRL2 GC01M081399 HNRNPA3P14
GH01F081305 0.7 ENCODE 6.4 +0.0 28 1.8 ZNF263 CTCF PKNOX1 ZNF654 L3MBTL2 ZNF792 ZNF501 REST RAD21 GATA3 ADGRL2 GC01M081399
GH01F081978 0.5 ENCODE 7.4 +672.8 672753 1.5 ZNF585B TEAD4 POU5F1 ATF2 ADGRL2 GC01P081981 GC01P081974
GH01F082044 0.2 ENCODE 8.1 +739.2 739238 1.6 ADGRL2 GC01P082002 GC01P082153
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRL2 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000539608 141 999 ZNF263 CTCF PKNOX1 ZNF654 L3MBTL2 ZNF792 ZNF501 REST RAD21 GATA3

Genomic Location for ADGRL2 Gene

Chromosome:
1
Start:
81,306,160 bp from pter
End:
81,992,738 bp from pter
Size:
686,579 bases
Orientation:
Plus strand

Genomic View for ADGRL2 Gene

Genes around ADGRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL2 Gene

Proteins for ADGRL2 Gene

  • Protein details for ADGRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95490-AGRL2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L2
    Protein Accession:
    O95490
    Secondary Accessions:
    • A5XEI2
    • B1ALT8
    • B1ALT9
    • B1ALU0
    • B1ALU2
    • B1ALU4
    • B1ALU5
    • B1ALU6
    • O94882
    • Q5VX76
    • Q9UKY5
    • Q9UKY6

    Protein attributes for ADGRL2 Gene

    Size:
    1459 amino acids
    Molecular mass:
    163349 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
    SequenceCaution:
    • Sequence=CAI22406.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL2 Gene

neXtProt entry for ADGRL2 Gene

Post-translational modifications for ADGRL2 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 99, Asn 331, Asn 520, Asn 629, Asn 731, Asn 744, Asn 787, Asn 792, and Asn 813
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ADGRL2

No data available for DME Specific Peptides for ADGRL2 Gene

Domains & Families for ADGRL2 Gene

Gene Families for ADGRL2 Gene

Suggested Antigen Peptide Sequences for ADGRL2 Gene

Graphical View of Domain Structure for InterPro Entry

O95490

UniProtKB/Swiss-Prot:

AGRL2_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
  • Contains 1 olfactomedin-like domain.
  • Contains 1 SUEL-type lectin domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL2: view

Function for ADGRL2 Gene

Molecular function for ADGRL2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.

Gene Ontology (GO) - Molecular Function for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016524 latrotoxin receptor activity NAS 10030676
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ADGRL2: view
genes like me logo Genes that share phenotypes with ADGRL2: view

Animal Models for ADGRL2 Gene

MGI Knock Outs for ADGRL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL2 Gene

Localization for ADGRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL2 gene
Compartment Confidence
plasma membrane 4
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10030676
genes like me logo Genes that share ontologies with ADGRL2: view

Pathways & Interactions for ADGRL2 Gene

genes like me logo Genes that share pathways with ADGRL2: view

Pathways by source for ADGRL2 Gene

2 BioSystems pathways for ADGRL2 Gene

Gene Ontology (GO) - Biological Process for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10030676
genes like me logo Genes that share ontologies with ADGRL2: view

No data available for SIGNOR curated interactions for ADGRL2 Gene

Drugs & Compounds for ADGRL2 Gene

(2) Drugs for ADGRL2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for ADGRL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADGRL2: view

Transcripts for ADGRL2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:

ExUns: 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b · 29c · 29d
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12:
SP13:

Relevant External Links for ADGRL2 Gene

GeneLoc Exon Structure for
ADGRL2
ECgene alternative splicing isoforms for
ADGRL2

Expression for ADGRL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRL2 Gene

This gene is overexpressed in Placenta (12.2), Gallbladder (11.4), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADGRL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADGRL2 Gene:

ADGRL2

mRNA Expression by UniProt/SwissProt for ADGRL2 Gene:

O95490-AGRL2_HUMAN
Tissue specificity: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
genes like me logo Genes that share expression patterns with ADGRL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ADGRL2 Gene

Orthologs for ADGRL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPHN2 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia LPHN2 34 35
  • 94.54 (n)
dog
(Canis familiaris)
Mammalia LPHN2 34 35
  • 93.8 (n)
oppossum
(Monodelphis domestica)
Mammalia LPHN2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7431 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn2 34 35
  • 87.41 (n)
Adgrl2 16
rat
(Rattus norvegicus)
Mammalia Lphn2 34
  • 86.77 (n)
chicken
(Gallus gallus)
Aves LPHN2 34 35
  • 85.97 (n)
lizard
(Anolis carolinensis)
Reptilia LPHN2 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lphn2 34
  • 81.53 (n)
Str.1058 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16778 34
zebrafish
(Danio rerio)
Actinopterygii CABZ01074906.1 35
  • 74 (a)
ManyToMany
lphn2a 34 35
  • 71.06 (n)
CU467642.1 35
  • 71 (a)
ManyToMany
CABZ01096573.1 35
  • 54 (a)
ManyToMany
FP245444.1 35
  • 46 (a)
ManyToMany
wufb72a08 34
worm
(Caenorhabditis elegans)
Secernentea lat-1 34 35
  • 45.4 (n)
Species where no ortholog for ADGRL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL2 Gene

ENSEMBL:
Gene Tree for ADGRL2 (if available)
TreeFam:
Gene Tree for ADGRL2 (if available)

Paralogs for ADGRL2 Gene

genes like me logo Genes that share paralogs with ADGRL2: view

Variants for ADGRL2 Gene

Sequence variations from dbSNP and Humsavar for ADGRL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157210 -- 81,544,761(+) TTTTC(A/G)TGGTA intron-variant
rs10157342 -- 81,544,639(+) TGTCC(C/T)AATTA intron-variant
rs10157355 -- 81,823,859(+) AATTA(A/C)ATAAT intron-variant
rs10157954 -- 81,823,775(+) TTCCA(A/G)GCAGA intron-variant
rs10158650 -- 81,825,437(+) TCCAC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRL2 Gene

Variant ID Type Subtype PubMed ID
esv1159587 CNV deletion 17803354
esv2659412 CNV deletion 23128226
esv3307207 CNV mobile element insertion 20981092
esv3308604 CNV mobile element insertion 20981092
esv3323603 CNV insertion 20981092
esv3380260 CNV insertion 20981092
esv3564837 CNV deletion 23714750
esv3577986 CNV loss 25503493
esv3586619 CNV loss 21293372
esv3586621 CNV loss 21293372
esv3586622 CNV gain 21293372
esv3586623 CNV loss 21293372
esv3586624 CNV loss 21293372
nsv437226 CNV loss 16327808
nsv437590 CNV loss 16327808
nsv473455 CNV novel sequence insertion 20440878
nsv506937 OTHER sequence alteration 20534489
nsv823331 CNV loss 20364138
nsv830359 CNV gain 17160897
nsv946023 CNV duplication 23825009

Variation tolerance for ADGRL2 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL2 Gene

Disorders for ADGRL2 Gene

Relevant External Links for ADGRL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL2

No disorders were found for ADGRL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRL2 Gene

Publications for ADGRL2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
  2. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. (PMID: 10760572) White G.R.M. … Heighway J. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. (PMID: 10030676) White G.R.M. … Heighway J. (Oncogene 1998) 3 4 22 64
  4. Discovery of tissue-specific exons using comprehensive human exon microarrays. (PMID: 17456239) Clark T.A. … Blume J.E. (Genome Biol. 2007) 3 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for ADGRL2 Gene

Sources for ADGRL2 Gene

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