Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRL1 Gene

Aliases for ADGRL1 Gene

  • Adhesion G Protein-Coupled Receptor L1 2 3 5
  • Calcium-Independent Alpha-Latrotoxin Receptor 1 3 4
  • Latrophilin 1 2 3
  • Latrophilin-1 3 4
  • Lectomedin-2 3 4
  • CIRL-1 3 4
  • LPHN1 3 4
  • LEC2 3 4
  • KIAA0821 4
  • CIRL1 3
  • CL1 3

External Ids for ADGRL1 Gene

Previous HGNC Symbols for ADGRL1 Gene

  • LPHN1

Summaries for ADGRL1 Gene

Entrez Gene Summary for ADGRL1 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for ADGRL1 Gene

ADGRL1 (Adhesion G Protein-Coupled Receptor L1) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL1 Gene

  • Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Wiki entry for ADGRL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL1 Gene

Genomics for ADGRL1 Gene

Regulatory Elements for ADGRL1 Gene

Enhancers for ADGRL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRL1 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRL1 Gene

Chromosome:
19
Start:
14,147,737 bp from pter
End:
14,206,248 bp from pter
Size:
58,512 bases
Orientation:
Minus strand

Genomic View for ADGRL1 Gene

Genes around ADGRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL1 Gene

Proteins for ADGRL1 Gene

  • Protein details for ADGRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94910-AGRL1_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L1
    Protein Accession:
    O94910
    Secondary Accessions:
    • Q96IE7
    • Q9BU07
    • Q9HAR3

    Protein attributes for ADGRL1 Gene

    Size:
    1474 amino acids
    Molecular mass:
    162717 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain. Interacts (via extracellular domain) with FLRT1, FLRT2 and FLRT3 (via extracellular domain) (By similarity).
    SequenceCaution:
    • Sequence=BAA74844.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRL1 Gene

Proteomics data for ADGRL1 Gene at MOPED

Post-translational modifications for ADGRL1 Gene

  • Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRL1 Gene

No data available for DME Specific Peptides for ADGRL1 Gene

Domains & Families for ADGRL1 Gene

Gene Families for ADGRL1 Gene

Suggested Antigen Peptide Sequences for ADGRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94910

UniProtKB/Swiss-Prot:

AGRL1_HUMAN :
  • The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.
  • Contains 1 GPS domain.
  • Contains 1 olfactomedin-like domain.
  • Contains 1 SUEL-type lectin domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL1: view

Function for ADGRL1 Gene

Molecular function for ADGRL1 Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050839 cell adhesion molecule binding ISS --
genes like me logo Genes that share ontologies with ADGRL1: view
genes like me logo Genes that share phenotypes with ADGRL1: view

Animal Models for ADGRL1 Gene

MGI Knock Outs for ADGRL1:

Animal Model Products

miRNA for ADGRL1 Gene

miRTarBase miRNAs that target ADGRL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL1 Gene

Localization for ADGRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL1 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250 UniProtKB:O88917}.

Gene Ontology (GO) - Cellular Components for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRL1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRL1 Gene

Pathways & Interactions for ADGRL1 Gene

SuperPathways for ADGRL1 Gene

genes like me logo Genes that share pathways with ADGRL1: view

Pathways by source for ADGRL1 Gene

1 BioSystems pathway for ADGRL1 Gene

Gene Ontology (GO) - Biological Process for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRL1: view

No data available for SIGNOR curated interactions for ADGRL1 Gene

Drugs & Compounds for ADGRL1 Gene

(1) Drugs for ADGRL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ADGRL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADGRL1: view

Transcripts for ADGRL1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ADGRL1 Gene

GeneLoc Exon Structure for
ADGRL1
ECgene alternative splicing isoforms for
ADGRL1

Expression for ADGRL1 Gene

mRNA expression in normal human tissues for ADGRL1 Gene

Protein differential expression in normal tissues from HIPED for ADGRL1 Gene

This gene is overexpressed in Brain (52.5) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRL1 Gene



genes like me logo Genes that share expression patterns with ADGRL1: view

Protein tissue co-expression partners for ADGRL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRL1 Gene

Orthologs for ADGRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPHN1 35
  • 91.78 (n)
  • 97.82 (a)
LPHN1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPHN1 35
  • 92.87 (n)
  • 98.91 (a)
LPHN1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn1 35
  • 89.15 (n)
  • 97.89 (a)
Adgrl1 16
Lphn1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPHN1 35
  • 99.68 (n)
  • 99.86 (a)
LPHN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lphn1 35
  • 89.42 (n)
  • 97.76 (a)
oppossum
(Monodelphis domestica)
Mammalia LPHN1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPHN1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPHN1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lphn1 35
  • 72.11 (n)
  • 80.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562531 35
  • 70.22 (n)
  • 73.77 (a)
LPHN1 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 28 (a)
OneToMany
Species with no ortholog for ADGRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL1 Gene

ENSEMBL:
Gene Tree for ADGRL1 (if available)
TreeFam:
Gene Tree for ADGRL1 (if available)

Paralogs for ADGRL1 Gene

genes like me logo Genes that share paralogs with ADGRL1: view

Variants for ADGRL1 Gene

Sequence variations from dbSNP and Humsavar for ADGRL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_049463 -
rs7507421 -- 14,199,542(+) gcctc(A/C)gcctc intron-variant
rs7507995 -- 14,180,286(+) agtct(C/G/T)gctct intron-variant
rs7508068 -- 14,197,785(+) GCTGG(C/T)TCTTG intron-variant
rs7508616 -- 14,206,334(+) ggggg(A/C)tgggg upstream-variant-2KB

Variation tolerance for ADGRL1 Gene

Residual Variation Intolerance Score: 0.994% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL1 Gene

HapMap Linkage Disequilibrium report
ADGRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRL1 Gene

Disorders for ADGRL1 Gene

Relevant External Links for ADGRL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL1

No disorders were found for ADGRL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRL1 Gene

Publications for ADGRL1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 67
  2. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3

Products for ADGRL1 Gene

Sources for ADGRL1 Gene

Content