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Aliases for ADGRL1 Gene

Aliases for ADGRL1 Gene

  • Adhesion G Protein-Coupled Receptor L1 2 3 5
  • Calcium-Independent Alpha-Latrotoxin Receptor 1 3 4
  • Latrophilin-1 3 4
  • Lectomedin-2 3 4
  • CIRL-1 3 4
  • LPHN1 3 4
  • LEC2 3 4
  • Latrophilin 1 2
  • KIAA0821 4
  • CIRL1 3
  • CL1 3

External Ids for ADGRL1 Gene

Previous HGNC Symbols for ADGRL1 Gene

  • LPHN1

Summaries for ADGRL1 Gene

Entrez Gene Summary for ADGRL1 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for ADGRL1 Gene

ADGRL1 (Adhesion G Protein-Coupled Receptor L1) is a Protein Coding gene. Diseases associated with ADGRL1 include Dermatophytosis. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and carbohydrate binding. An important paralog of this gene is ADGRL2.

UniProtKB/Swiss-Prot for ADGRL1 Gene

  • Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).

Gene Wiki entry for ADGRL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL1 Gene

Genomics for ADGRL1 Gene

Regulatory Elements for ADGRL1 Gene

Enhancers for ADGRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G014080 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.7 +124.8 124848 2.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 PRKACA CCDC130 PALM3 ZNF333 MRI1 TRMT1 ADGRE5 ZSWIM4 ADGRL1 RFX1
GH19G013864 1.4 FANTOM5 ENCODE dbSUPER 6.3 +341.4 341427 1.5 HDGF KLF17 ZNF2 THRB ZNF48 GLIS2 KLF7 EGR2 ZEB2 ZFP69B ADGRL1 CACNA1A C19orf57 CC2D1A NANOS3 MIR181C
GH19G014216 1.5 Ensembl ENCODE dbSUPER 5.4 -11.1 -11081 1.5 HDGF PKNOX1 SIN3A ZNF2 ZNF121 GTF3C2 ZNF143 ZNF207 KLF13 ZNF202 CCDC130 DCAF15 MRI1 RFX1 ZSWIM4 ADGRL1 RN7SL231P ENSG00000267406
GH19G013865 1.4 FANTOM5 ENCODE dbSUPER 3.1 +339.9 339908 1.0 HDGF PKNOX1 ZSCAN4 GLIS2 BCLAF1 EGR2 ZNF398 GATAD2B ZFP69B ZNF341 SNRPGP15 CACNA1A ADGRL1 ZSWIM4 RFX1 C19orf57 NANOS3 MIR181C
GH19G014163 0.8 FANTOM5 2.9 +42.4 42423 0.3 SMARCE1 CTCF USF2 ELF1 MNT ZNF398 FOSL1 ARID1B ZNF766 GATA2 PRKACA ADGRL1 C19orf57 RFX1 PIR54415 GC19P014171
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRL1 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107505 -352 2401 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 KLF13

Genomic Location for ADGRL1 Gene

Chromosome:
19
Start:
14,147,737 bp from pter
End:
14,206,248 bp from pter
Size:
58,512 bases
Orientation:
Minus strand

Genomic View for ADGRL1 Gene

Genes around ADGRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL1 Gene

Proteins for ADGRL1 Gene

  • Protein details for ADGRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94910-AGRL1_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor L1
    Protein Accession:
    O94910
    Secondary Accessions:
    • Q96IE7
    • Q9BU07
    • Q9HAR3

    Protein attributes for ADGRL1 Gene

    Size:
    1474 amino acids
    Molecular mass:
    162717 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain. Interacts (via extracellular domain) with FLRT1, FLRT2 and FLRT3 (via extracellular domain) (By similarity).
    SequenceCaution:
    • Sequence=BAA74844.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRL1 Gene

Post-translational modifications for ADGRL1 Gene

  • Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRL1 Gene

Domains & Families for ADGRL1 Gene

Gene Families for ADGRL1 Gene

Suggested Antigen Peptide Sequences for ADGRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94910

UniProtKB/Swiss-Prot:

AGRL1_HUMAN :
  • The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRL1: view

Function for ADGRL1 Gene

Molecular function for ADGRL1 Gene

UniProtKB/Swiss-Prot Function:
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 21078624
GO:0016524 latrotoxin receptor activity ISS --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ADGRL1: view
genes like me logo Genes that share phenotypes with ADGRL1: view

Animal Models for ADGRL1 Gene

MGI Knock Outs for ADGRL1:

Animal Model Products

CRISPR Products

miRNA for ADGRL1 Gene

miRTarBase miRNAs that target ADGRL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRL1 Gene

Localization for ADGRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL1 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250 UniProtKB:O88917}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRL1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with ADGRL1: view

Pathways & Interactions for ADGRL1 Gene

SuperPathways for ADGRL1 Gene

SuperPathway Contained pathways
1 GPCRs, Class B Secretin-like
genes like me logo Genes that share pathways with ADGRL1: view

Pathways by source for ADGRL1 Gene

1 BioSystems pathway for ADGRL1 Gene

Gene Ontology (GO) - Biological Process for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035584 calcium-mediated signaling using intracellular calcium source ISS --
genes like me logo Genes that share ontologies with ADGRL1: view

No data available for SIGNOR curated interactions for ADGRL1 Gene

Drugs & Compounds for ADGRL1 Gene

(1) Drugs for ADGRL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ADGRL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADGRL1: view

Transcripts for ADGRL1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ADGRL1 Gene

GeneLoc Exon Structure for
ADGRL1
ECgene alternative splicing isoforms for
ADGRL1

Expression for ADGRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRL1 Gene

Protein differential expression in normal tissues from HIPED for ADGRL1 Gene

This gene is overexpressed in Brain (52.5) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADGRL1 Gene



Protein tissue co-expression partners for ADGRL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRL1 Gene:

ADGRL1

Evidence on tissue expression from TISSUES for ADGRL1 Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with ADGRL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRL1 Gene

Orthologs for ADGRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPHN1 34 35
  • 99.68 (n)
oppossum
(Monodelphis domestica)
Mammalia LPHN1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPHN1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPHN1 34 35
  • 92.87 (n)
cow
(Bos Taurus)
Mammalia LPHN1 35 34
  • 91.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lphn1 34
  • 89.42 (n)
mouse
(Mus musculus)
Mammalia Lphn1 34 35
  • 89.15 (n)
Adgrl1 16
lizard
(Anolis carolinensis)
Reptilia LPHN1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lphn1 34
  • 72.11 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562531 34
  • 70.22 (n)
LPHN1 35
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lat-1 35
  • 28 (a)
OneToMany
Species where no ortholog for ADGRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL1 Gene

ENSEMBL:
Gene Tree for ADGRL1 (if available)
TreeFam:
Gene Tree for ADGRL1 (if available)

Paralogs for ADGRL1 Gene

genes like me logo Genes that share paralogs with ADGRL1: view

Variants for ADGRL1 Gene

Sequence variations from dbSNP and Humsavar for ADGRL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000095606 -- 14,148,310(+) CACCC(A/G)GCGAT intron-variant, utr-variant-3-prime
rs1000162009 -- 14,160,523(+) CTCCA(C/G/T)GACCC intron-variant
rs1000163874 -- 14,182,243(+) AATTA(-/TTG)TTATT intron-variant
rs1000259042 -- 14,160,798(+) ACGAG(C/T)GGGCG intron-variant
rs1000272514 -- 14,154,202(+) GGGCC(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRL1 Gene

Variant ID Type Subtype PubMed ID
dgv49n68 CNV loss 17160897
esv3643735 CNV loss 21293372
nsv1072864 CNV deletion 25765185
nsv2423 CNV insertion 18451855
nsv517436 CNV loss 19592680
nsv578642 CNV gain 21841781
nsv578663 CNV loss 21841781
nsv828452 CNV loss 20364138
nsv953980 CNV deletion 24416366

Variation tolerance for ADGRL1 Gene

Residual Variation Intolerance Score: 0.994% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRL1 Gene

Human Gene Mutation Database (HGMD)
ADGRL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRL1 Gene

Disorders for ADGRL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dermatophytosis
  • tinea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRL1
genes like me logo Genes that share disorders with ADGRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRL1 Gene

Publications for ADGRL1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 64
  2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64

Products for ADGRL1 Gene

Sources for ADGRL1 Gene

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