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Aliases for ADGRL1 Gene

Aliases for ADGRL1 Gene

  • Adhesion G Protein-Coupled Receptor L1 2 3
  • Calcium-Independent Alpha-Latrotoxin Receptor 1 3 4
  • Latrophilin 1 2 3
  • Lectomedin-2 3 4
  • CIRL-1 3 4
  • LPHN1 3 4
  • LEC2 3 4
  • Latrophilin-1 3
  • KIAA0821 4
  • CIRL1 3
  • CL1 3

External Ids for ADGRL1 Gene

Previous Symbols for ADGRL1 Gene

  • LPHN1

Summaries for ADGRL1 Gene

Entrez Gene Summary for ADGRL1 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for ADGRL1 Gene

ADGRL1 (Adhesion G Protein-Coupled Receptor L1) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL1 Gene

  • Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Wiki entry for ADGRL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL1 Gene

Genomics for ADGRL1 Gene

Genomic Location for ADGRL1 Gene

Start:
14,147,737 bp from pter
End:
14,206,187 bp from pter
Size:
58,451 bases
Orientation:
Minus strand

Genomic View for ADGRL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL1 Gene

No data available for Regulatory Elements for ADGRL1 Gene

Proteins for ADGRL1 Gene

  • Protein details for ADGRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94910-LPHN1_HUMAN
    Recommended name:
    Latrophilin-1
    Protein Accession:
    O94910
    Secondary Accessions:
    • Q96IE7
    • Q9BU07
    • Q9HAR3

    Protein attributes for ADGRL1 Gene

    Size:
    1474 amino acids
    Molecular mass:
    162717 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain (By similarity).
    SequenceCaution:
    • Sequence=BAA74844.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRL1 Gene

Proteomics data for ADGRL1 Gene at MOPED

Post-translational modifications for ADGRL1 Gene

  • Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRL1 Gene

No data available for DME Specific Peptides for ADGRL1 Gene

Domains for ADGRL1 Gene

Gene Families for ADGRL1 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

LPHN1_HUMAN
Domain:
  • The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.:
    • O94910
  • Contains 1 GPS domain.:
    • O94910
  • Contains 1 olfactomedin-like domain.:
    • O94910
  • Contains 1 SUEL-type lectin domain.:
    • O94910
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • O94910
genes like me logo Genes that share domains with ADGRL1: view

Function for ADGRL1 Gene

Molecular function for ADGRL1 Gene

UniProtKB/Swiss-Prot Function: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 21078624
GO:0016524 latrotoxin receptor activity ISS --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ADGRL1: view

Phenotypes for ADGRL1 Gene

genes like me logo Genes that share phenotypes with ADGRL1: view

Animal Models for ADGRL1 Gene

MGI Knock Outs for ADGRL1:

miRNA for ADGRL1 Gene

miRTarBase miRNAs that target ADGRL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADGRL1 Gene

Localization for ADGRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL1 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon ISS --
genes like me logo Genes that share ontologies with ADGRL1: view

Pathways for ADGRL1 Gene

SuperPathways for ADGRL1 Gene

genes like me logo Genes that share pathways with ADGRL1: view

Pathways by source for ADGRL1 Gene

1 BioSystems pathway for ADGRL1 Gene

Gene Ontology (GO) - Biological Process for ADGRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS --
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
GO:0035584 calcium-mediated signaling using intracellular calcium source ISS --
genes like me logo Genes that share ontologies with ADGRL1: view

Compounds for ADGRL1 Gene

(1) Novoseek inferred chemical compound relationships for ADGRL1 Gene

Compound -log(P) Hits PubMed IDs
alpha-latrotoxin 94.7 13
genes like me logo Genes that share compounds with ADGRL1: view

Transcripts for ADGRL1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL1 Gene

No ASD Table

Relevant External Links for ADGRL1 Gene

GeneLoc Exon Structure for
ADGRL1
ECgene alternative splicing isoforms for
ADGRL1

Expression for ADGRL1 Gene

mRNA expression in normal human tissues for ADGRL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRL1 Gene

genes like me logo Genes that share expressions with ADGRL1: view

Orthologs for ADGRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPHN1 36
  • 99.68 (n)
  • 99.86 (a)
LPHN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPHN1 36
  • 91.78 (n)
  • 97.82 (a)
LPHN1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPHN1 36
  • 92.87 (n)
  • 98.91 (a)
LPHN1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn1 36
  • 89.15 (n)
  • 97.89 (a)
Lphn1 16
Lphn1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPHN1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPHN1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lphn1 36
  • 89.42 (n)
  • 97.76 (a)
lizard
(Anolis carolinensis)
Reptilia LPHN1 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lphn1 36
  • 72.11 (n)
  • 80.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562531 36
  • 70.22 (n)
  • 73.77 (a)
LPHN1 37
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lat-1 37
  • 28 (a)
OneToMany
Species with no ortholog for ADGRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL1 Gene

ENSEMBL:
Gene Tree for ADGRL1 (if available)
TreeFam:
Gene Tree for ADGRL1 (if available)

Paralogs for ADGRL1 Gene

genes like me logo Genes that share paralogs with ADGRL1: view

Variants for ADGRL1 Gene

Sequence variations from dbSNP and Humsavar for ADGRL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs31581 -- 14,175,927(+) tgcgt(A/G)cctgt intron-variant
rs40282 -- 14,183,023(+) GTAAT(C/T)GAGTA intron-variant
rs385356 -- 14,175,627(-) TGTCT(C/T)TGAgt intron-variant
rs408964 -- 14,175,649(+) acaca(C/T)ctgca intron-variant
rs431776 -- 14,195,038(-) gcatg(G/T)ttttg intron-variant

Relevant External Links for ADGRL1 Gene

HapMap Linkage Disequilibrium report
ADGRL1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRL1 Gene

Disorders for ADGRL1 Gene

No disorders were found for ADGRL1 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRL1 Gene

Publications for ADGRL1 Gene

  1. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3

Products for ADGRL1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRL1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRL1
    • Block miRNA regulation of ADGRL1 using miScript Target Protectors

    Sources for ADGRL1 Gene

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