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Aliases for ADGRG7 Gene

Aliases for ADGRG7 Gene

  • Adhesion G Protein-Coupled Receptor G7 2 3 5
  • G Protein-Coupled Receptor 128 2 3
  • G-Protein Coupled Receptor 128 3 4
  • GPR128 3 4

External Ids for ADGRG7 Gene

Previous HGNC Symbols for ADGRG7 Gene

  • GPR128

Summaries for ADGRG7 Gene

GeneCards Summary for ADGRG7 Gene

ADGRG7 (Adhesion G Protein-Coupled Receptor G7) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF2.

UniProtKB/Swiss-Prot for ADGRG7 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRG7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG7 Gene

Genomics for ADGRG7 Gene

Genomic Location for ADGRG7 Gene

Chromosome:
3
Start:
100,609,589 bp from pter
End:
100,695,479 bp from pter
Size:
85,891 bases
Orientation:
Plus strand

Genomic View for ADGRG7 Gene

Genes around ADGRG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG7 Gene

No data available for Regulatory Elements for ADGRG7 Gene

Proteins for ADGRG7 Gene

  • Protein details for ADGRG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K78-AGRG7_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G7
    Protein Accession:
    Q96K78
    Secondary Accessions:
    • Q14D94
    • Q86SQ2

    Protein attributes for ADGRG7 Gene

    Size:
    797 amino acids
    Molecular mass:
    88909 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO27358.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG7 Gene

Proteomics data for ADGRG7 Gene at MOPED

Post-translational modifications for ADGRG7 Gene

  • Glycosylation at Asn 82, Asn 159, Asn 178, Asn 191, Asn 247, Asn 261, Asn 312, Asn 316, Asn 387, and Asn 413
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRG7 Gene

Domains & Families for ADGRG7 Gene

Gene Families for ADGRG7 Gene

Protein Domains for ADGRG7 Gene

Suggested Antigen Peptide Sequences for ADGRG7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K78

UniProtKB/Swiss-Prot:

AGRG7_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG7: view

Function for ADGRG7 Gene

Molecular function for ADGRG7 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ADGRG7: view
genes like me logo Genes that share phenotypes with ADGRG7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRG7 Gene

Localization for ADGRG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG7 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRG7: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG7 Gene

Pathways & Interactions for ADGRG7 Gene

SuperPathways for ADGRG7 Gene

No Data Available

Interacting Proteins for ADGRG7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273352%0d%0a9606.ENSP00000345656%0d%0a9606.ENSP00000360411%0d%0a
Selected Interacting proteins: Q96K78-AGRG7_HUMAN ENSP00000273352 for ADGRG7 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for ADGRG7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRG7 Gene

Drugs & Compounds for ADGRG7 Gene

No Compound Related Data Available

Transcripts for ADGRG7 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG7 Gene

No ASD Table

Relevant External Links for ADGRG7 Gene

GeneLoc Exon Structure for
ADGRG7
ECgene alternative splicing isoforms for
ADGRG7

Expression for ADGRG7 Gene

mRNA expression in normal human tissues for ADGRG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG7 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG7 Gene



genes like me logo Genes that share expression patterns with ADGRG7: view

Protein tissue co-expression partners for ADGRG7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRG7 Gene

Orthologs for ADGRG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR128 35
  • 81.78 (n)
  • 73.23 (a)
GPR128 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR128 35
  • 80.6 (n)
  • 70.28 (a)
GPR128 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr128 35
  • 76.85 (n)
  • 71.1 (a)
Adgrg7 16
Gpr128 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR128 35
  • 99.83 (n)
  • 99.75 (a)
GPR128 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911145 35
  • 76.93 (n)
  • 71.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPR128 35
  • 57.52 (n)
  • 47.12 (a)
GPR128 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101882620 35
  • 49.33 (n)
  • 40.69 (a)
gpr128 36
  • 38 (a)
OneToMany
GPR128 (1 of 2) 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToOne
Species with no ortholog for ADGRG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG7 Gene

ENSEMBL:
Gene Tree for ADGRG7 (if available)
TreeFam:
Gene Tree for ADGRG7 (if available)

Paralogs for ADGRG7 Gene

Paralogs for ADGRG7 Gene

Pseudogenes.org Pseudogenes for ADGRG7 Gene

genes like me logo Genes that share paralogs with ADGRG7: view

Variants for ADGRG7 Gene

Sequence variations from dbSNP and Humsavar for ADGRG7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16842529 - 100,659,797(+) TTATT(A/T)CAATC reference, missense
rs9872512 - 100,694,874(+) GCTGC(A/G)TGTAA reference, missense
rs1144122 - 100,635,680(+) AGGTA(A/G)AGGAT reference, missense, utr-variant-5-prime
rs425142 -- 100,684,877(-) ATTAT(C/T)ACCTT intron-variant
rs343895 -- 100,620,464(+) atggg(A/C)aaaaa intron-variant

Variation tolerance for ADGRG7 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRG7 Gene

HapMap Linkage Disequilibrium report
ADGRG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRG7 Gene

Disorders for ADGRG7 Gene

Relevant External Links for ADGRG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRG7

No disorders were found for ADGRG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG7 Gene

Publications for ADGRG7 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals. (PMID: 19797732) Chase A. … Cross N.C. (Haematologica 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for ADGRG7 Gene

Sources for ADGRG7 Gene

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