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Aliases for ADGRG6 Gene

Aliases for ADGRG6 Gene

  • Adhesion G Protein-Coupled Receptor G6 2 3
  • GPR126 3 4 6
  • VIGR 3 4 6
  • Developmentally Regulated G-Protein-Coupled Receptor 3 4
  • Vascular Inducible G Protein-Coupled Receptor 3 4
  • G Protein-Coupled Receptor 126 2 3
  • DREG 3 4
  • Vascular-Inducible G Protein-Coupled Receptor 3
  • HBV PreS1-Transactivated Protein 2 3
  • G-Protein Coupled Receptor 126 3
  • PS1TP2 3
  • APG1 3

External Ids for ADGRG6 Gene

Previous HGNC Symbols for ADGRG6 Gene

  • GPR126

Summaries for ADGRG6 Gene

Entrez Gene Summary for ADGRG6 Gene

  • This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for ADGRG6 Gene

ADGRG6 (Adhesion G Protein-Coupled Receptor G6) is a Protein Coding gene. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG6 Gene

  • Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).

Gene Wiki entry for ADGRG6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG6 Gene

Genomics for ADGRG6 Gene

Genomic Location for ADGRG6 Gene

142,301,854 bp from pter
142,446,266 bp from pter
144,413 bases
Plus strand

Genomic View for ADGRG6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG6 Gene

No data available for Regulatory Elements for ADGRG6 Gene

Proteins for ADGRG6 Gene

  • Protein details for ADGRG6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 126
    Protein Accession:
    Secondary Accessions:
    • Q5TGN7
    • Q6DHZ4
    • Q6F3F5
    • Q6F3F6
    • Q6F3F7
    • Q6F3F8
    • Q6MZU7
    • Q8IXA4
    • Q8NC14
    • Q96JW0

    Protein attributes for ADGRG6 Gene

    1221 amino acids
    Molecular mass:
    136695 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO13250.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=BAB55406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45930.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20053.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRG6 Gene


neXtProt entry for ADGRG6 Gene

Proteomics data for ADGRG6 Gene at MOPED

Post-translational modifications for ADGRG6 Gene

  • Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRG6 Gene

Domains for ADGRG6 Gene

Gene Families for ADGRG6 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Q86SQ4
  • Contains 1 CUB domain.
  • Contains 1 GPS domain.
  • Contains 1 pentaxin domain.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRG6: view

No data available for Suggested Antigen Peptide Sequences for ADGRG6 Gene

Function for ADGRG6 Gene

Molecular function for ADGRG6 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.

Gene Ontology (GO) - Molecular Function for ADGRG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG6: view
genes like me logo Genes that share phenotypes with ADGRG6: view

Animal Models for ADGRG6 Gene

MGI Knock Outs for ADGRG6:

miRNA for ADGRG6 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADGRG6 Gene

Localization for ADGRG6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG6 Gene

Cell membrane; Multi-pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein.

Gene Ontology (GO) - Cellular Components for ADGRG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRG6: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG6 Gene

Pathways for ADGRG6 Gene

SuperPathways for ADGRG6 Gene

No Data Available

Interacting Proteins for ADGRG6 Gene

Gene Ontology (GO) - Biological Process for ADGRG6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRG6: view

No data available for Pathways by source for ADGRG6 Gene

Transcripts for ADGRG6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: -
SP3: - -
SP4: - -

ExUns: 24 ^ 25 ^ 26 ^ 27a · 27b
SP2: -
SP4: -

Relevant External Links for ADGRG6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG6 Gene

mRNA expression in normal human tissues for ADGRG6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRG6 Gene

mRNA Expression by UniProt/SwissProt for ADGRG6 Gene

Tissue specificity: Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
genes like me logo Genes that share expressions with ADGRG6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADGRG6 Gene

Orthologs for ADGRG6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR126 35
  • 99.6 (n)
  • 99.52 (a)
GPR126 36
  • 99 (a)
(Bos Taurus)
Mammalia GPR126 35
  • 88.13 (n)
  • 86.96 (a)
GPR126 36
  • 85 (a)
(Canis familiaris)
Mammalia GPR126 35
  • 89.52 (n)
  • 89.2 (a)
GPR126 36
  • 89 (a)
(Mus musculus)
Mammalia Gpr126 35
  • 83.3 (n)
  • 84.19 (a)
Gpr126 16
Gpr126 36
  • 84 (a)
(Monodelphis domestica)
Mammalia GPR126 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia GPR126 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Gpr126 35
  • 83.21 (n)
  • 83.88 (a)
(Gallus gallus)
Aves GPR126 35
  • 69.54 (n)
  • 66.61 (a)
GPR126 36
  • 66 (a)
(Anolis carolinensis)
Reptilia GPR126 36
  • 63 (a)
(Danio rerio)
Actinopterygii Dr.1140 35
gpr126 35
  • 56.97 (n)
  • 51.8 (a)
gpr126 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for ADGRG6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADGRG6 Gene

Gene Tree for ADGRG6 (if available)
Gene Tree for ADGRG6 (if available)

Paralogs for ADGRG6 Gene

genes like me logo Genes that share paralogs with ADGRG6: view

Variants for ADGRG6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG6 Gene

Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIM:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits

Sequence variations from dbSNP and Humsavar for ADGRG6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs723990 -- 142,371,861(+) ATTGG(A/G)TGACT intron-variant
rs962554 -- 142,413,067(+) TCATG(C/T)TCTCT intron-variant
rs972982 -- 142,345,724(+) CTATT(C/T)GTCTG intron-variant
rs989946 -- 142,397,664(+) AATTT(A/G)GAAGG synonymous-codon, reference
rs1013902 -- 142,398,591(+) GGCAC(A/G)GCTTG intron-variant

Relevant External Links for ADGRG6 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRG6 Gene

Disorders for ADGRG6 Gene

No disorders were found for ADGRG6 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRG6 Gene

Publications for ADGRG6 Gene

  1. VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells. (PMID: 15225624) Stehlik C. … Lipp J. (FEBS Lett. 2004) 3 4 23
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen T.Z. … Pandey A. (Mol. Cell. Proteomics 2004) 3 4
  5. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. (PMID: 15189448) Moriguchi T. … Akiyama T. (Genes Cells 2004) 3 4

Products for ADGRG6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRG6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG6
    • Block miRNA regulation of ADGRG6 using miScript Target Protectors

    Sources for ADGRG6 Gene

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