Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRG5 Gene

Aliases for ADGRG5 Gene

  • Adhesion G Protein-Coupled Receptor G5 2 3 5
  • G-Protein Coupled Receptor PGR27 3 4
  • G Protein-Coupled Receptor 114 2 3
  • GPR114 3 4
  • PGR27 3 4
  • Probable G-Protein Coupled Receptor 114 3
  • G Protein-Coupled Receptor PGR27 3
  • G-Protein Coupled Receptor 114 4

External Ids for ADGRG5 Gene

Previous HGNC Symbols for ADGRG5 Gene

  • GPR114

Previous GeneCards Identifiers for ADGRG5 Gene

  • GC16P057542

Summaries for ADGRG5 Gene

Entrez Gene Summary for ADGRG5 Gene

  • This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for ADGRG5 Gene

ADGRG5 (Adhesion G Protein-Coupled Receptor G5) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL1.

UniProtKB/Swiss-Prot for ADGRG5 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG5 Gene

Genomics for ADGRG5 Gene

Regulatory Elements for ADGRG5 Gene

Enhancers for ADGRG5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRG5 Gene

Chromosome:
16
Start:
57,529,333 bp from pter
End:
57,591,681 bp from pter
Size:
62,349 bases
Orientation:
Plus strand

Genomic View for ADGRG5 Gene

Genes around ADGRG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG5 Gene

Proteins for ADGRG5 Gene

  • Protein details for ADGRG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF4-AGRG5_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G5
    Protein Accession:
    Q8IZF4
    Secondary Accessions:
    • B3KXZ5
    • Q6ZMH7
    • Q6ZML4
    • Q86SL8
    • Q8IZ14

    Protein attributes for ADGRG5 Gene

    Size:
    528 amino acids
    Molecular mass:
    59000 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN46670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD18748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG5 Gene

Proteomics data for ADGRG5 Gene at MOPED

Post-translational modifications for ADGRG5 Gene

  • Glycosylation at Asn 58, Asn 65, Asn 146, Asn 147, Asn 173, Asn 179, Asn 394, and Asn 400
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG5 Gene

No data available for DME Specific Peptides for ADGRG5 Gene

Domains & Families for ADGRG5 Gene

Gene Families for ADGRG5 Gene

Suggested Antigen Peptide Sequences for ADGRG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZF4

UniProtKB/Swiss-Prot:

AGRG5_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG5: view

Function for ADGRG5 Gene

Molecular function for ADGRG5 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with ADGRG5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRG5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRG5 Gene

Localization for ADGRG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG5 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRG5: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG5 Gene

Pathways & Interactions for ADGRG5 Gene

SuperPathways for ADGRG5 Gene

No Data Available

Interacting Proteins for ADGRG5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000290823%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000290823 for ADGRG5 Gene via STRING

Symbol External ID(s) Details
SRPK2

Gene Ontology (GO) - Biological Process for ADGRG5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRG5 Gene

Drugs & Compounds for ADGRG5 Gene

No Compound Related Data Available

Transcripts for ADGRG5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for ADGRG5 Gene

GeneLoc Exon Structure for
ADGRG5
ECgene alternative splicing isoforms for
ADGRG5

Expression for ADGRG5 Gene

mRNA expression in normal human tissues for ADGRG5 Gene

Protein differential expression in normal tissues from HIPED for ADGRG5 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG5 Gene



mRNA Expression by UniProt/SwissProt for ADGRG5 Gene

Q8IZF4-AGRG5_HUMAN
Tissue specificity: Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.
genes like me logo Genes that share expression patterns with ADGRG5: view

Protein tissue co-expression partners for ADGRG5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADGRG5 Gene

Orthologs for ADGRG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR114 35
  • 82.11 (n)
  • 75.68 (a)
GPR114 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR114 35
  • 79.44 (n)
  • 72.41 (a)
GPR114 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr114 35
  • 75.46 (n)
  • 70.75 (a)
Adgrg5 16
Gpr114 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR114 35
  • 91.77 (n)
  • 89.16 (a)
GPR114 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr114 35
  • 75.67 (n)
  • 71.46 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR114 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR114 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR114 35
  • 58.08 (n)
  • 46.1 (a)
GPR114 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gpr56 36
  • 20 (a)
OneToMany
Species with no ortholog for ADGRG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG5 Gene

ENSEMBL:
Gene Tree for ADGRG5 (if available)
TreeFam:
Gene Tree for ADGRG5 (if available)

Paralogs for ADGRG5 Gene

genes like me logo Genes that share paralogs with ADGRG5: view

Variants for ADGRG5 Gene

Sequence variations from dbSNP and Humsavar for ADGRG5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4140664 -- 57,544,732(+) AATGA(G/T)TTCCT intron-variant
rs9921158 -- 57,563,685(+) GAAGG(C/G)CTGGG intron-variant
rs9922499 -- 57,566,167(+) TTGGC(A/G)TTAGG intron-variant
rs9923054 -- 57,554,609(+) ctgac(C/T)ttgtg intron-variant
rs60991236 -- 57,555,948(+) TGTAG(A/C)ACTTC intron-variant

Variation tolerance for ADGRG5 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRG5 Gene

Disorders for ADGRG5 Gene

Relevant External Links for ADGRG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRG5

No disorders were found for ADGRG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG5 Gene

Publications for ADGRG5 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 3
  3. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. (PMID: 26499266) Wilde C. … Liebscher I. (FASEB J. 2016) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. (PMID: 20600896) Engelman C.D. … Norris J.M. (J. Steroid Biochem. Mol. Biol. 2010) 3

Products for ADGRG5 Gene

Sources for ADGRG5 Gene

Content