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Aliases for ADGRG5 Gene

Aliases for ADGRG5 Gene

  • Adhesion G Protein-Coupled Receptor G5 2 3
  • G-Protein Coupled Receptor PGR27 3 4
  • G Protein-Coupled Receptor 114 2 3
  • GPR114 3 4
  • PGR27 3 4
  • Probable G-Protein Coupled Receptor 114 3
  • G Protein-Coupled Receptor PGR27 3
  • G-Protein Coupled Receptor 114 3

External Ids for ADGRG5 Gene

Previous Symbols for ADGRG5 Gene

  • GPR114

Summaries for ADGRG5 Gene

GeneCards Summary for ADGRG5 Gene

ADGRG5 (Adhesion G Protein-Coupled Receptor G5) is a Protein Coding gene. An important paralog of this gene is ADGRL1.

UniProtKB/Swiss-Prot for ADGRG5 Gene

  • Orphan receptor

Gene Wiki entry for ADGRG5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG5 Gene

Genomics for ADGRG5 Gene

Genomic Location for ADGRG5 Gene

57,542,421 bp from pter
57,591,681 bp from pter
49,261 bases
Plus strand

Genomic View for ADGRG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG5 Gene

No data available for Regulatory Elements for ADGRG5 Gene

Proteins for ADGRG5 Gene

  • Protein details for ADGRG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 114
    Protein Accession:
    Secondary Accessions:
    • B3KXZ5
    • Q6ZMH7
    • Q6ZML4
    • Q86SL8
    • Q8IZ14

    Protein attributes for ADGRG5 Gene

    528 amino acids
    Molecular mass:
    59000 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN46670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD18748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADGRG5 Gene

Proteomics data for ADGRG5 Gene at MOPED

Post-translational modifications for ADGRG5 Gene

No Post-translational modifications

Other Protein References for ADGRG5 Gene

No data available for DME Specific Peptides for ADGRG5 Gene

Domains for ADGRG5 Gene

Gene Families for ADGRG5 Gene

  • GPCRBO :GPCR / Class B : Orphans


  • Contains 1 GPS domain.:
    • Q8IZF4
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q8IZF4
genes like me logo Genes that share domains with ADGRG5: view

Function for ADGRG5 Gene

Molecular function for ADGRG5 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor

Gene Ontology (GO) - Molecular Function for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG5: view

Phenotypes for ADGRG5 Gene

GenomeRNAi human phenotypes for ADGRG5:
genes like me logo Genes that share phenotypes with ADGRG5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRG5 Gene

Localization for ADGRG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG5 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRG5: view

Pathways for ADGRG5 Gene

SuperPathways for ADGRG5 Gene

No Data Available

Interacting Proteins for ADGRG5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000290823 for ADGRG5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADGRG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRG5: view

No data available for Pathways by source for ADGRG5 Gene

Transcripts for ADGRG5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG5 Gene

No ASD Table

Relevant External Links for ADGRG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG5 Gene

mRNA expression in normal human tissues for ADGRG5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRG5 Gene

genes like me logo Genes that share expressions with ADGRG5: view

Orthologs for ADGRG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR114 36
  • 91.77 (n)
  • 89.16 (a)
GPR114 37
  • 99 (a)
(Bos Taurus)
Mammalia GPR114 36
  • 82.11 (n)
  • 75.68 (a)
GPR114 37
  • 73 (a)
(Canis familiaris)
Mammalia GPR114 36
  • 79.44 (n)
  • 72.41 (a)
GPR114 37
  • 71 (a)
(Mus musculus)
Mammalia Gpr114 36
  • 75.46 (n)
  • 70.75 (a)
Gpr114 16
Gpr114 37
  • 70 (a)
(Monodelphis domestica)
Mammalia GPR114 37
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia GPR114 37
  • 48 (a)
(Rattus norvegicus)
Mammalia Gpr114 36
  • 75.67 (n)
  • 71.46 (a)
(Gallus gallus)
Aves GPR114 36
  • 58.08 (n)
  • 46.1 (a)
GPR114 37
  • 46 (a)
(Danio rerio)
Actinopterygii gpr56 37
  • 20 (a)
Species with no ortholog for ADGRG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG5 Gene

Gene Tree for ADGRG5 (if available)
Gene Tree for ADGRG5 (if available)

Paralogs for ADGRG5 Gene

genes like me logo Genes that share paralogs with ADGRG5: view

Variants for ADGRG5 Gene

Sequence variations from dbSNP and Humsavar for ADGRG5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10802 -- 57,576,884(+) CAGGC(A/G)GAAAA utr-variant-3-prime
rs581703 -- 57,549,979(+) atcta(A/T)acatt intron-variant
rs1004363 -- 57,562,087(+) TCTGC(A/G)CAGGG utr-variant-5-prime
rs1004911 -- 57,541,485(-) GAAGG(C/T)TTTGC upstream-variant-2KB
rs1016996 -- 57,560,769(+) ccaac(A/G)aactc intron-variant

Relevant External Links for ADGRG5 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRG5 Gene

Disorders for ADGRG5 Gene

No disorders were found for ADGRG5 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRG5 Gene

Publications for ADGRG5 Gene

  1. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ADGRG5 Gene

Sources for ADGRG5 Gene

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