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Aliases for ADGRG3 Gene

Aliases for ADGRG3 Gene

  • Adhesion G Protein-Coupled Receptor G3 2 3 5
  • G-Protein Coupled Receptor PGR26 3 4
  • G Protein-Coupled Receptor 97 2 3
  • GPR97 3 4
  • PGR26 3 4
  • Probable G-Protein Coupled Receptor 97 3
  • G-Protein Coupled Receptor 97 4
  • PB99 3

External Ids for ADGRG3 Gene

Previous HGNC Symbols for ADGRG3 Gene

  • GPR97

Summaries for ADGRG3 Gene

GeneCards Summary for ADGRG3 Gene

ADGRG3 (Adhesion G Protein-Coupled Receptor G3) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG1.

UniProtKB/Swiss-Prot for ADGRG3 Gene

  • Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Wiki entry for ADGRG3 Gene

Additional gene information for ADGRG3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG3 Gene

Genomics for ADGRG3 Gene

Regulatory Elements for ADGRG3 Gene

Enhancers for ADGRG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H057666 1.7 FANTOM5 Ensembl ENCODE 77.6 +0.2 231 3 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF766 ZNF143 ZHX2 MXD4 ZNF592 ADGRG3 DRC7 RSPRY1 ZNF319 SETD6 ENSG00000261114 ENSG00000260467 FAM192A USB1
GH16H057891 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +225.4 225437 3 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 RSPRY1 ADGRG3 CSNK2A2 SETD6 KIFC3 LOC388282 CNGB1 ADGRG1 CNOT1 CFAP20
GH16H057600 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -66.2 -66231 3 HDGF PKNOX1 SIN3A ARID4B DMAP1 TCF12 ZNF143 ATF7 RUNX3 JUNB ADGRG3 ADGRG5 HMGB3P32 GC16P057594
GH16H057626 1.6 Ensembl ENCODE dbSUPER 11.8 -39.4 -39403 4 HDGF PKNOX1 SIN3A YBX1 ZNF2 ZNF766 ZNF302 ZNF416 ZNF207 ZNF548 RSPRY1 LOC101927556 POLR2C NUP93 LOC105371286 SETD6 LOC100421594 LOC100125393 ENSG00000260148 RN7SL645P
GH16H057633 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -31.4 -31405 6 TBP MLX ARID4B DMAP1 BMI1 ZBTB40 RFX5 FOS CREM MIXL1 ADGRG1 ADGRG3 CCL17 PLLP CX3CL1 GC16M057629 GC16P057639
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRG3 Gene

Chromosome:
16
Start:
57,668,187 bp from pter
End:
57,689,378 bp from pter
Size:
21,192 bases
Orientation:
Plus strand

Genomic View for ADGRG3 Gene

Genes around ADGRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG3 Gene

Proteins for ADGRG3 Gene

  • Protein details for ADGRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y34-AGRG3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor G3
    Protein Accession:
    Q86Y34
    Secondary Accessions:
    • Q6ZMF4
    • Q86SL9
    • Q8IZF1

    Protein attributes for ADGRG3 Gene

    Size:
    549 amino acids
    Molecular mass:
    60861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18774.1; Type=Frameshift; Positions=492; Evidence={ECO:0000305};

neXtProt entry for ADGRG3 Gene

Post-translational modifications for ADGRG3 Gene

  • Glycosylation at Asn98, posLast=144144, Asn210, and posLast=413413
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRG3 Gene

Domains & Families for ADGRG3 Gene

Gene Families for ADGRG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y34

UniProtKB/Swiss-Prot:

AGRG3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG3: view

Function for ADGRG3 Gene

Molecular function for ADGRG3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Ontology (GO) - Molecular Function for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG3: view
genes like me logo Genes that share phenotypes with ADGRG3: view

Animal Models for ADGRG3 Gene

MGI Knock Outs for ADGRG3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRG3 Gene

Localization for ADGRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRG3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRG3 Gene

Pathways & Interactions for ADGRG3 Gene

genes like me logo Genes that share pathways with ADGRG3: view

Pathways by source for ADGRG3 Gene

3 Reactome pathways for ADGRG3 Gene

Interacting Proteins for ADGRG3 Gene

Gene Ontology (GO) - Biological Process for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 22575658
GO:0030183 B cell differentiation ISS,IEA --
GO:0030334 regulation of cell migration IMP 24178298
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for SIGNOR curated interactions for ADGRG3 Gene

Drugs & Compounds for ADGRG3 Gene

(1) Drugs for ADGRG3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beclomethasone dipropionate Approved, Investigational Pharma Corticosteroid used for asthma and rhinitis 0
genes like me logo Genes that share compounds with ADGRG3: view

Transcripts for ADGRG3 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3: -

Relevant External Links for ADGRG3 Gene

GeneLoc Exon Structure for
ADGRG3
ECgene alternative splicing isoforms for
ADGRG3

Expression for ADGRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG3 Gene

This gene is overexpressed in Neutrophil (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRG3 Gene



Protein tissue co-expression partners for ADGRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG3 Gene:

ADGRG3

mRNA Expression by UniProt/SwissProt for ADGRG3 Gene:

Q86Y34-AGRG3_HUMAN
Tissue specificity: Expressed in cultured primary dermal lymphatic endothelial cells.

Evidence on tissue expression from TISSUES for ADGRG3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ADGRG3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRG3 Gene

Orthologs for ADGRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR97 33 34
  • 89.94 (n)
cow
(Bos Taurus)
Mammalia GPR97 33 34
  • 77.27 (n)
dog
(Canis familiaris)
Mammalia GPR97 33 34
  • 76.54 (n)
rat
(Rattus norvegicus)
Mammalia Gpr97 33
  • 76.14 (n)
mouse
(Mus musculus)
Mammalia Gpr97 33 34
  • 75.76 (n)
Adgrg3 16
oppossum
(Monodelphis domestica)
Mammalia GPR97 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR97 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR97 33 34
  • 56.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799479 33
  • 51.31 (n)
GPR97 34
  • 28 (a)
OneToOne
Species where no ortholog for ADGRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG3 Gene

ENSEMBL:
Gene Tree for ADGRG3 (if available)
TreeFam:
Gene Tree for ADGRG3 (if available)

Paralogs for ADGRG3 Gene

Paralogs for ADGRG3 Gene

genes like me logo Genes that share paralogs with ADGRG3: view

Variants for ADGRG3 Gene

Sequence variations from dbSNP and Humsavar for ADGRG3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000099356 -- 57,672,037(+) TAGCC(A/G)GGCAT intron-variant
rs1000320039 -- 57,669,729(+) AGCAT(C/T)GATGG intron-variant
rs1000691433 -- 57,685,880(+) CCGTT(A/G)GGCCT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1001533262 -- 57,674,830(+) AATAC(A/C)AAAAA intron-variant
rs1001647753 -- 57,674,611(+) TAGCA(A/C)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG3 Gene

Variant ID Type Subtype PubMed ID
nsv1065634 CNV gain 25217958
nsv833246 CNV loss 17160897

Variation tolerance for ADGRG3 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG3 Gene

Disorders for ADGRG3 Gene

Relevant External Links for ADGRG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRG3

No disorders were found for ADGRG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG3 Gene

Publications for ADGRG3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 60
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 60
  3. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. (PMID: 24178298) Valtcheva N … Detmar M (The Journal of biological chemistry 2013) 3 4 60
  4. Signaling property study of adhesion G-protein-coupled receptors. (PMID: 22575658) Gupte J … Wu X (FEBS letters 2012) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for ADGRG3 Gene

Sources for ADGRG3 Gene

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