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Aliases for ADGRG3 Gene

Aliases for ADGRG3 Gene

  • Adhesion G Protein-Coupled Receptor G3 2 3
  • G-Protein Coupled Receptor PGR26 3 4
  • G Protein-Coupled Receptor 97 2 3
  • G-Protein Coupled Receptor 97 3 4
  • GPR97 3 4
  • PGR26 3 4
  • Probable G-Protein Coupled Receptor 97 3
  • PB99 3

External Ids for ADGRG3 Gene

Previous HGNC Symbols for ADGRG3 Gene

  • GPR97

Summaries for ADGRG3 Gene

GeneCards Summary for ADGRG3 Gene

ADGRG3 (Adhesion G Protein-Coupled Receptor G3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG3 Gene

  • Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Wiki entry for ADGRG3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG3 Gene

Genomics for ADGRG3 Gene

Genomic Location for ADGRG3 Gene

Chromosome:
16
Start:
57,668,187 bp from pter
End:
57,689,378 bp from pter
Size:
21,192 bases
Orientation:
Plus strand

Genomic View for ADGRG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG3 Gene

No data available for Regulatory Elements for ADGRG3 Gene

Proteins for ADGRG3 Gene

  • Protein details for ADGRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y34-AGRG3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor G3
    Protein Accession:
    Q86Y34
    Secondary Accessions:
    • Q6ZMF4
    • Q86SL9
    • Q8IZF1

    Protein attributes for ADGRG3 Gene

    Size:
    549 amino acids
    Molecular mass:
    60861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18774.1; Type=Frameshift; Positions=492; Evidence={ECO:0000305};

neXtProt entry for ADGRG3 Gene

Proteomics data for ADGRG3 Gene at MOPED

Post-translational modifications for ADGRG3 Gene

  • Glycosylation at Asn 98, Asn 144, Asn 210, and Asn 413
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRG3 Gene

No data available for DME Specific Peptides for ADGRG3 Gene

Domains & Families for ADGRG3 Gene

Gene Families for ADGRG3 Gene

Suggested Antigen Peptide Sequences for ADGRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y34

UniProtKB/Swiss-Prot:

AGRG3_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG3: view

Function for ADGRG3 Gene

Molecular function for ADGRG3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).

Gene Ontology (GO) - Molecular Function for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG3: view

Phenotypes for ADGRG3 Gene

genes like me logo Genes that share phenotypes with ADGRG3: view

Animal Models for ADGRG3 Gene

MGI Knock Outs for ADGRG3:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRG3 Gene

Localization for ADGRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IMP 22575658
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG3 Gene

Pathways & Interactions for ADGRG3 Gene

SuperPathways for ADGRG3 Gene

No Data Available

Interacting Proteins for ADGRG3 Gene

Gene Ontology (GO) - Biological Process for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 22575658
GO:0030183 B cell differentiation ISS --
GO:0030334 regulation of cell migration IMP 24178298
GO:0032792 negative regulation of CREB transcription factor activity ISS --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRG3 Gene

Drugs & Compounds for ADGRG3 Gene

(1) Drugs for ADGRG3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beclomethasone Approved, Investigational Pharma 155
genes like me logo Genes that share compounds with ADGRG3: view

Transcripts for ADGRG3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3: -

Relevant External Links for ADGRG3 Gene

GeneLoc Exon Structure for
ADGRG3
ECgene alternative splicing isoforms for
ADGRG3

Expression for ADGRG3 Gene

mRNA expression in normal human tissues for ADGRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG3 Gene

This gene is overexpressed in Neutrophil (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG3 Gene



mRNA Expression by UniProt/SwissProt for ADGRG3 Gene

Q86Y34-AGRG3_HUMAN
Tissue specificity: Expressed in cultured primary dermal lymphatic endothelial cells.
genes like me logo Genes that share expression patterns with ADGRG3: view

Protein tissue co-expression partners for ADGRG3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADGRG3 Gene

Orthologs for ADGRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR97 35
  • 77.27 (n)
  • 67.99 (a)
GPR97 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR97 35
  • 76.54 (n)
  • 68.68 (a)
GPR97 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr97 35
  • 75.76 (n)
  • 69.76 (a)
Gpr97 16
Gpr97 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR97 35
  • 89.94 (n)
  • 87.55 (a)
GPR97 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr97 35
  • 76.14 (n)
  • 70.66 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR97 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR97 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR97 35
  • 56.04 (n)
  • 41 (a)
GPR97 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC799479 35
  • 51.31 (n)
  • 38.92 (a)
GPR97 36
  • 28 (a)
OneToOne
Species with no ortholog for ADGRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG3 Gene

ENSEMBL:
Gene Tree for ADGRG3 (if available)
TreeFam:
Gene Tree for ADGRG3 (if available)

Paralogs for ADGRG3 Gene

genes like me logo Genes that share paralogs with ADGRG3: view

Variants for ADGRG3 Gene

Sequence variations from dbSNP and Humsavar for ADGRG3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs180686317 -- 57,688,523(+) GCTCC(A/G)TGCCT utr-variant-3-prime, missense, reference, nc-transcript-variant
rs180691623 -- 57,671,896(+) CTCAT(A/G)CCTAT intron-variant
rs180909228 -- 57,684,616(+) CCTCA(A/G)ATCCA intron-variant, downstream-variant-500B
rs151150032 -- 57,666,366(+) AGGGC(A/G)CCAAC upstream-variant-2KB
rs151006986 -- 57,682,362(+) CCCTC(C/T)GCCCT intron-variant

Variation tolerance for ADGRG3 Gene

Residual Variation Intolerance Score: 54.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRG3 Gene

HapMap Linkage Disequilibrium report
ADGRG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRG3 Gene

Disorders for ADGRG3 Gene

Relevant External Links for ADGRG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRG3
genes like me logo Genes that share disorders with ADGRG3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG3 Gene

Publications for ADGRG3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 67
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 67
  3. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. (PMID: 24178298) Valtcheva N. … Detmar M. (J. Biol. Chem. 2013) 67
  4. Signaling property study of adhesion G-protein-coupled receptors. (PMID: 22575658) Gupte J. … Wu X. (FEBS Lett. 2012) 67
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 67

Products for ADGRG3 Gene

Sources for ADGRG3 Gene

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