Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRG3 Gene

Aliases for ADGRG3 Gene

  • Adhesion G Protein-Coupled Receptor G3 2 3
  • G-Protein Coupled Receptor PGR26 3 4
  • G Protein-Coupled Receptor 97 2 3
  • GPR97 3 4
  • PGR26 3 4
  • Probable G-Protein Coupled Receptor 97 3
  • PB99 3

External Ids for ADGRG3 Gene

Previous HGNC Symbols for ADGRG3 Gene

  • GPR97

Summaries for ADGRG3 Gene

GeneCards Summary for ADGRG3 Gene

ADGRG3 (Adhesion G Protein-Coupled Receptor G3) is a Protein Coding gene. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG3 Gene

  • Orphan receptor

Gene Wiki entry for ADGRG3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG3 Gene

Genomics for ADGRG3 Gene

Genomic Location for ADGRG3 Gene

57,668,187 bp from pter
57,689,378 bp from pter
21,192 bases
Plus strand

Genomic View for ADGRG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG3 Gene

No data available for Regulatory Elements for ADGRG3 Gene

Proteins for ADGRG3 Gene

  • Protein details for ADGRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 97
    Protein Accession:
    Secondary Accessions:
    • Q6ZMF4
    • Q86SL9
    • Q8IZF1

    Protein attributes for ADGRG3 Gene

    549 amino acids
    Molecular mass:
    60861 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18774.1; Type=Frameshift; Positions=492; Evidence={ECO:0000305};

neXtProt entry for ADGRG3 Gene

Proteomics data for ADGRG3 Gene at MOPED

Post-translational modifications for ADGRG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRG3 Gene

No data available for DME Specific Peptides for ADGRG3 Gene

Domains for ADGRG3 Gene

Gene Families for ADGRG3 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Q86Y34
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRG3: view

No data available for Suggested Antigen Peptide Sequences for ADGRG3 Gene

Function for ADGRG3 Gene

Molecular function for ADGRG3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG3: view

Phenotypes for ADGRG3 Gene

MGI mutant phenotypes for ADGRG3:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRG3:
genes like me logo Genes that share phenotypes with ADGRG3: view

Animal Models for ADGRG3 Gene

MGI Knock Outs for ADGRG3:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRG3 Gene

Localization for ADGRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG3 Gene

Pathways for ADGRG3 Gene

SuperPathways for ADGRG3 Gene

No Data Available

Interacting Proteins for ADGRG3 Gene

Gene Ontology (GO) - Biological Process for ADGRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRG3: view

No data available for Pathways by source for ADGRG3 Gene

Transcripts for ADGRG3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3: -

Relevant External Links for ADGRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG3 Gene

mRNA expression in normal human tissues for ADGRG3 Gene

Protein differential expression in normal tissues for ADGRG3 Gene

This gene is overexpressed in Neutrophil (68.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRG3 Gene

genes like me logo Genes that share expressions with ADGRG3: view

Expression partners for ADGRG3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRG3 Gene

Orthologs for ADGRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR97 35
  • 77.27 (n)
  • 67.99 (a)
GPR97 36
  • 66 (a)
(Canis familiaris)
Mammalia GPR97 35
  • 76.54 (n)
  • 68.68 (a)
GPR97 36
  • 68 (a)
(Mus musculus)
Mammalia Gpr97 35
  • 75.76 (n)
  • 69.76 (a)
Gpr97 16
Gpr97 36
  • 69 (a)
(Pan troglodytes)
Mammalia GPR97 35
  • 89.94 (n)
  • 87.55 (a)
GPR97 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Gpr97 35
  • 76.14 (n)
  • 70.66 (a)
(Monodelphis domestica)
Mammalia GPR97 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia GPR97 36
  • 50 (a)
(Gallus gallus)
Aves GPR97 35
  • 56.04 (n)
  • 41 (a)
GPR97 36
  • 39 (a)
(Danio rerio)
Actinopterygii LOC799479 35
  • 51.31 (n)
  • 38.92 (a)
GPR97 36
  • 28 (a)
Species with no ortholog for ADGRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG3 Gene

Gene Tree for ADGRG3 (if available)
Gene Tree for ADGRG3 (if available)

Paralogs for ADGRG3 Gene

genes like me logo Genes that share paralogs with ADGRG3: view

Variants for ADGRG3 Gene

Sequence variations from dbSNP and Humsavar for ADGRG3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs727215 -- 57,684,910(+) gattc(A/C)cagta intron-variant
rs727216 -- 57,684,871(+) ccagc(C/G)aggtg intron-variant
rs727217 -- 57,684,658(+) GCCTA(A/G)AGAGA intron-variant
rs730733 -- 57,677,167(+) GAAAG(C/T)TGGGG intron-variant
rs731960 -- 57,686,329(-) AAAAC(A/G)GCATG intron-variant

Relevant External Links for ADGRG3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRG3 Gene

Disorders for ADGRG3 Gene

No disorders were found for ADGRG3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ADGRG3 Gene

Publications for ADGRG3 Gene

  1. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 3 4
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADGRG3 Gene

Sources for ADGRG3 Gene

Back to Top