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Aliases for ADGRG2 Gene

Aliases for ADGRG2 Gene

  • Adhesion G Protein-Coupled Receptor G2 2 3 5
  • Human Epididymis-Specific Protein 6 3 4
  • G Protein-Coupled Receptor 64 2 3
  • Epididymal Protein 6 2 3
  • TM7LN2 3 4
  • GPR64 3 4
  • HE6 3 4
  • G Protein-Coupled Receptor, Epididymis-Specific (Seven Transmembrane Family) 3
  • G-Protein Coupled Receptor 64 4
  • EDDM6 3

External Ids for ADGRG2 Gene

Previous HGNC Symbols for ADGRG2 Gene

  • GPR64

Summaries for ADGRG2 Gene

Entrez Gene Summary for ADGRG2 Gene

  • This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ADGRG2 Gene

ADGRG2 (Adhesion G Protein-Coupled Receptor G2) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG2 Gene

  • Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.

Gene Wiki entry for ADGRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG2 Gene

Genomics for ADGRG2 Gene

Regulatory Elements for ADGRG2 Gene

Enhancers for ADGRG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRG2 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRG2 Gene

18,989,307 bp from pter
19,122,931 bp from pter
133,625 bases
Minus strand

Genomic View for ADGRG2 Gene

Genes around ADGRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG2 Gene

Proteins for ADGRG2 Gene

  • Protein details for ADGRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor G2
    Protein Accession:
    Secondary Accessions:
    • B1AWB3
    • B1AWB4
    • B1AWB6
    • B1AWB7
    • O00406
    • Q14CE0
    • Q8IWT2
    • Q8IZE4
    • Q8IZE5
    • Q8IZE6
    • Q8IZE7
    • Q8IZP3
    • Q8IZP4

    Protein attributes for ADGRG2 Gene

    1017 amino acids
    Molecular mass:
    111593 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

    Alternative splice isoforms for ADGRG2 Gene

neXtProt entry for ADGRG2 Gene

Proteomics data for ADGRG2 Gene at MOPED

Post-translational modifications for ADGRG2 Gene

  • Highly glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 44, Asn 85, Asn 99, Asn 111, Asn 117, Asn 144, Asn 162, Asn 186, Asn 194, Thr 268, Ser 271, Thr 277, Asn 357, Asn 370, Asn 435, Asn 438, Asn 456, Asn 461, Asn 528, Asn 542, Asn 547, Asn 551, Asn 597, and Asn 857
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRG2 Gene

Domains & Families for ADGRG2 Gene

Gene Families for ADGRG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG2: view

Function for ADGRG2 Gene

Molecular function for ADGRG2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.
genes like me logo Genes that share phenotypes with ADGRG2: view

Animal Models for ADGRG2 Gene

MGI Knock Outs for ADGRG2:

miRNA for ADGRG2 Gene

miRTarBase miRNAs that target ADGRG2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRG2 Gene

Localization for ADGRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG2 Gene

Apical cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9150425
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with ADGRG2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG2 Gene

Pathways & Interactions for ADGRG2 Gene

SuperPathways for ADGRG2 Gene

genes like me logo Genes that share pathways with ADGRG2: view

Pathways by source for ADGRG2 Gene

1 BioSystems pathway for ADGRG2 Gene

Interacting Proteins for ADGRG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369198 for ADGRG2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADGRG2 Gene


No data available for SIGNOR curated interactions for ADGRG2 Gene

Drugs & Compounds for ADGRG2 Gene

No Compound Related Data Available

Transcripts for ADGRG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG2 Gene

No ASD Table

Relevant External Links for ADGRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG2 Gene

mRNA expression in normal human tissues for ADGRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG2 Gene

This gene is overexpressed in Platelet (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRG2 Gene

mRNA Expression by UniProt/SwissProt for ADGRG2 Gene

Tissue specificity: Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
genes like me logo Genes that share expression patterns with ADGRG2: view

Protein tissue co-expression partners for ADGRG2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRG2 Gene

Orthologs for ADGRG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR64 35
  • 86.92 (n)
  • 83.87 (a)
GPR64 36
  • 84 (a)
(Canis familiaris)
Mammalia GPR64 35
  • 87.79 (n)
  • 85.49 (a)
GPR64 36
  • 86 (a)
(Mus musculus)
Mammalia Gpr64 35
  • 84.36 (n)
  • 81.81 (a)
Adgrg2 16
Gpr64 36
  • 82 (a)
(Pan troglodytes)
Mammalia GPR64 35
  • 98.75 (n)
  • 98.32 (a)
GPR64 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr64 35
  • 83.32 (n)
  • 81.17 (a)
(Monodelphis domestica)
Mammalia GPR64 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia GPR64 36
  • 66 (a)
(Gallus gallus)
Aves GPR64 35
  • 68.2 (n)
  • 64.99 (a)
GPR64 36
  • 57 (a)
(Anolis carolinensis)
Reptilia GPR64 36
  • 59 (a)
(Danio rerio)
Actinopterygii CABZ01049802.1 36
  • 37 (a)
GPR64 (2 of 2) 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for ADGRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADGRG2 Gene

Gene Tree for ADGRG2 (if available)
Gene Tree for ADGRG2 (if available)

Paralogs for ADGRG2 Gene

genes like me logo Genes that share paralogs with ADGRG2: view

Variants for ADGRG2 Gene

Sequence variations from dbSNP and Humsavar for ADGRG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_055289 -
VAR_055290 -
rs747680907 -- 19,097,277(+) GAGGC(C/T)AAGGC intron-variant
rs747732292 -- 19,085,084(+) AAATA(C/T)ACACA intron-variant
rs747758644 -- 19,105,221(+) GTGTT(A/T)TTCTC intron-variant

Variation tolerance for ADGRG2 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRG2 Gene

Disorders for ADGRG2 Gene

Relevant External Links for ADGRG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG2 Gene

Publications for ADGRG2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. (PMID: 12420295) Obermann H. … Kirchhoff C. (Mol. Reprod. Dev. 2003) 3 23
  3. Function of human epididymal proteins in sperm maturation. (PMID: 9739419) Kirchhoff C. … SchrAPter S. (Andrologia 1998) 2 3
  4. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. (PMID: 9150425) Osterhoff C. … Kirchhoff C. (DNA Cell Biol. 1997) 2 3
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3

Products for ADGRG2 Gene

Sources for ADGRG2 Gene