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Aliases for ADGRG2 Gene

Aliases for ADGRG2 Gene

  • Adhesion G Protein-Coupled Receptor G2 2 3
  • GPR64 3 4 6
  • HE6 3 4 6
  • Human Epididymis-Specific Protein 6 3 4
  • G Protein-Coupled Receptor 64 2 3
  • Epididymal Protein 6 2 3
  • TM7LN2 3 4
  • G Protein-Coupled Receptor, Epididymis-Specific (Seven Transmembrane Family) 3
  • G-Protein Coupled Receptor 64 3
  • EDDM6 3

External Ids for ADGRG2 Gene

Previous Symbols for ADGRG2 Gene

  • GPR64

Summaries for ADGRG2 Gene

Entrez Gene Summary for ADGRG2 Gene

  • This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ADGRG2 Gene

ADGRG2 (Adhesion G Protein-Coupled Receptor G2) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG2 Gene

  • Could be involved in a signal transduction pathway controlling epididymal function and male fertility

Gene Wiki entry for ADGRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG2 Gene

Genomics for ADGRG2 Gene

Genomic Location for ADGRG2 Gene

18,989,307 bp from pter
19,122,924 bp from pter
133,618 bases
Minus strand

Genomic View for ADGRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG2 Gene

No data available for Regulatory Elements for ADGRG2 Gene

Proteins for ADGRG2 Gene

  • Protein details for ADGRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 64
    Protein Accession:
    Secondary Accessions:
    • B1AWB3
    • B1AWB4
    • B1AWB6
    • B1AWB7
    • O00406
    • Q14CE0
    • Q8IWT2
    • Q8IZE4
    • Q8IZE5
    • Q8IZE6
    • Q8IZE7
    • Q8IZP3
    • Q8IZP4

    Protein attributes for ADGRG2 Gene

    1017 amino acids
    Molecular mass:
    111593 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.

    Alternative splice isoforms for ADGRG2 Gene

neXtProt entry for ADGRG2 Gene

Proteomics data for ADGRG2 Gene at MOPED

Post-translational modifications for ADGRG2 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRG2 Gene

Domains for ADGRG2 Gene

Gene Families for ADGRG2 Gene

  • GPCRBO :GPCR / Class B : Orphans


  • Contains 1 GPS domain.:
    • Q8IZP9
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q8IZP9
genes like me logo Genes that share domains with ADGRG2: view

Function for ADGRG2 Gene

Molecular function for ADGRG2 Gene

UniProtKB/Swiss-Prot Function: Could be involved in a signal transduction pathway controlling epididymal function and male fertility

Gene Ontology (GO) - Molecular Function for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG2: view
genes like me logo Genes that share phenotypes with ADGRG2: view

miRNA for ADGRG2 Gene

miRTarBase miRNAs that target ADGRG2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRG2 Gene

Localization for ADGRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9150425
GO:0009986 cell surface IDA 19581412
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 12420295
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with ADGRG2: view

Pathways for ADGRG2 Gene

SuperPathways for ADGRG2 Gene

genes like me logo Genes that share pathways with ADGRG2: view

Pathways by source for ADGRG2 Gene

1 BioSystems pathway for ADGRG2 Gene

Interacting Proteins for ADGRG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369198 for ADGRG2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
GO:0007283 spermatogenesis TAS 9150425
genes like me logo Genes that share ontologies with ADGRG2: view

Transcripts for ADGRG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG2 Gene

No ASD Table

Relevant External Links for ADGRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRG2 Gene

mRNA expression in normal human tissues for ADGRG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRG2 Gene

mRNA Expression by UniProt/SwissProt for ADGRG2 Gene

Tissue specificity: Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia
genes like me logo Genes that share expressions with ADGRG2: view

Orthologs for ADGRG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR64 36
  • 98.75 (n)
  • 98.32 (a)
GPR64 37
  • 100 (a)
(Bos Taurus)
Mammalia GPR64 36
  • 86.92 (n)
  • 83.87 (a)
GPR64 37
  • 84 (a)
(Canis familiaris)
Mammalia GPR64 36
  • 87.79 (n)
  • 85.49 (a)
GPR64 37
  • 86 (a)
(Mus musculus)
Mammalia Gpr64 36
  • 84.36 (n)
  • 81.81 (a)
Gpr64 16
Gpr64 37
  • 82 (a)
(Monodelphis domestica)
Mammalia GPR64 37
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia GPR64 37
  • 66 (a)
(Rattus norvegicus)
Mammalia Gpr64 36
  • 83.32 (n)
  • 81.17 (a)
(Gallus gallus)
Aves GPR64 36
  • 68.2 (n)
  • 64.99 (a)
GPR64 37
  • 57 (a)
(Anolis carolinensis)
Reptilia GPR64 37
  • 59 (a)
(Danio rerio)
Actinopterygii CABZ01049802.1 37
  • 37 (a)
GPR64 (2 of 2) 37
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 37
  • 10 (a)
(Caenorhabditis elegans)
Secernentea lat-2 37
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
Species with no ortholog for ADGRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADGRG2 Gene

Gene Tree for ADGRG2 (if available)
Gene Tree for ADGRG2 (if available)

Paralogs for ADGRG2 Gene

genes like me logo Genes that share paralogs with ADGRG2: view

Variants for ADGRG2 Gene

Sequence variations from dbSNP and Humsavar for ADGRG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1123799 -- 19,106,312(+) CAGCT(A/C)GTGGC intron-variant
rs1458178 -- 19,091,062(-) acata(C/T)tactt intron-variant
rs1551598 -- 19,110,463(-) tcaag(G/T)gatcc intron-variant
rs2385613 -- 19,108,678(+) TACCA(C/T)ATATA intron-variant
rs4262425 -- 19,111,542(-) ggcac(C/G)atttg intron-variant

Relevant External Links for ADGRG2 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRG2 Gene

Disorders for ADGRG2 Gene

No disorders were found for ADGRG2 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRG2 Gene

Publications for ADGRG2 Gene

  1. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. (PMID: 9150425) Osterhoff C. … Kirchhoff C. (DNA Cell Biol. 1997) 2 3 4
  2. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. (PMID: 12420295) Obermann H. … Kirchhoff C. (Mol. Reprod. Dev. 2003) 3 4 23
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  4. Function of human epididymal proteins in sperm maturation. (PMID: 9739419) Kirchhoff C. … SchrAPter S. (Andrologia 1998) 2 3
  5. Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site. (PMID: 11973329) Abe J. … Hirose S. (J. Biol. Chem. 2002) 3

Products for ADGRG2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRG2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG2
    • Block miRNA regulation of ADGRG2 using miScript Target Protectors

    Sources for ADGRG2 Gene

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