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Aliases for ADGRG2 Gene

Aliases for ADGRG2 Gene

  • Adhesion G Protein-Coupled Receptor G2 2 3 5
  • Human Epididymis-Specific Protein 6 3 4
  • G Protein-Coupled Receptor 64 2 3
  • Epididymal Protein 6 2 3
  • TM7LN2 3 4
  • GPR64 3 4
  • HE6 3 4
  • G Protein-Coupled Receptor, Epididymis-Specific (Seven Transmembrane Family) 3
  • Adhesion G-Protein Coupled Receptor G2 3
  • G-Protein Coupled Receptor 64 4
  • EDDM6 3

External Ids for ADGRG2 Gene

Previous HGNC Symbols for ADGRG2 Gene

  • GPR64

Summaries for ADGRG2 Gene

Entrez Gene Summary for ADGRG2 Gene

  • This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ADGRG2 Gene

ADGRG2 (Adhesion G Protein-Coupled Receptor G2) is a Protein Coding gene. Among its related pathways are GPCRs, Class B Secretin-like. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG6.

UniProtKB/Swiss-Prot for ADGRG2 Gene

  • Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.

Gene Wiki entry for ADGRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG2 Gene

Genomics for ADGRG2 Gene

Regulatory Elements for ADGRG2 Gene

Enhancers for ADGRG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ADGRG2 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ADGRG2 Gene

Chromosome:
X
Start:
18,989,307 bp from pter
End:
19,122,931 bp from pter
Size:
133,625 bases
Orientation:
Minus strand

Genomic View for ADGRG2 Gene

Genes around ADGRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG2 Gene

Proteins for ADGRG2 Gene

  • Protein details for ADGRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZP9-AGRG2_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor G2
    Protein Accession:
    Q8IZP9
    Secondary Accessions:
    • B1AWB3
    • B1AWB4
    • B1AWB6
    • B1AWB7
    • O00406
    • Q14CE0
    • Q8IWT2
    • Q8IZE4
    • Q8IZE5
    • Q8IZE6
    • Q8IZE7
    • Q8IZP3
    • Q8IZP4

    Protein attributes for ADGRG2 Gene

    Size:
    1017 amino acids
    Molecular mass:
    111593 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

    Alternative splice isoforms for ADGRG2 Gene

neXtProt entry for ADGRG2 Gene

Post-translational modifications for ADGRG2 Gene

  • Highly glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 44, Asn 85, Asn 99, Asn 111, Asn 117, Asn 144, Asn 162, Asn 186, Asn 194, Thr 268, Ser 271, Thr 277, Asn 357, Asn 370, Asn 435, Asn 438, Asn 456, Asn 461, Asn 528, Asn 542, Asn 547, Asn 551, Asn 597, and Asn 857
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRG2 Gene

Domains & Families for ADGRG2 Gene

Gene Families for ADGRG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZP9

UniProtKB/Swiss-Prot:

AGRG2_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRG2: view

Function for ADGRG2 Gene

Molecular function for ADGRG2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.

Gene Ontology (GO) - Molecular Function for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRG2: view
genes like me logo Genes that share phenotypes with ADGRG2: view

Animal Models for ADGRG2 Gene

MGI Knock Outs for ADGRG2:

Animal Model Products

miRNA for ADGRG2 Gene

miRTarBase miRNAs that target ADGRG2

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRG2 Gene

Localization for ADGRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG2 Gene

Apical cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9150425
GO:0009986 cell surface IDA 19581412
GO:0016021 integral component of membrane TAS 12420295
GO:0016324 apical plasma membrane ISS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with ADGRG2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG2 Gene

Pathways & Interactions for ADGRG2 Gene

SuperPathways for ADGRG2 Gene

genes like me logo Genes that share pathways with ADGRG2: view

Pathways by source for ADGRG2 Gene

1 BioSystems pathway for ADGRG2 Gene

Interacting Proteins for ADGRG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369198%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000369198 Q8IZP9-AGRG2_HUMAN for ADGRG2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADGRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007283 spermatogenesis TAS 9150425
genes like me logo Genes that share ontologies with ADGRG2: view

No data available for SIGNOR curated interactions for ADGRG2 Gene

Drugs & Compounds for ADGRG2 Gene

No Compound Related Data Available

Transcripts for ADGRG2 Gene

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG2 Gene

No ASD Table

Relevant External Links for ADGRG2 Gene

GeneLoc Exon Structure for
ADGRG2
ECgene alternative splicing isoforms for
ADGRG2

Expression for ADGRG2 Gene

mRNA expression in normal human tissues for ADGRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRG2 Gene

This gene is overexpressed in Platelet (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADGRG2 Gene



Protein tissue co-expression partners for ADGRG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRG2 Gene:

ADGRG2

mRNA Expression by UniProt/SwissProt for ADGRG2 Gene:

Q8IZP9-AGRG2_HUMAN
Tissue specificity: Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
genes like me logo Genes that share expression patterns with ADGRG2: view

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRG2 Gene

Orthologs for ADGRG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR64 34
  • 86.92 (n)
  • 83.87 (a)
GPR64 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR64 34
  • 87.79 (n)
  • 85.49 (a)
GPR64 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr64 34
  • 84.36 (n)
  • 81.81 (a)
Adgrg2 16
Gpr64 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR64 34
  • 98.75 (n)
  • 98.32 (a)
GPR64 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr64 34
  • 83.32 (n)
  • 81.17 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR64 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR64 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR64 34
  • 68.2 (n)
  • 64.99 (a)
GPR64 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR64 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01049802.1 35
  • 37 (a)
OneToMany
GPR64 (2 of 2) 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cirl 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lat-2 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ADGRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADGRG2 Gene

ENSEMBL:
Gene Tree for ADGRG2 (if available)
TreeFam:
Gene Tree for ADGRG2 (if available)

Paralogs for ADGRG2 Gene

genes like me logo Genes that share paralogs with ADGRG2: view

Variants for ADGRG2 Gene

Sequence variations from dbSNP and Humsavar for ADGRG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_055289 -
VAR_055290 -
rs747680907 -- 19,097,277(+) GAGGC(C/T)AAGGC intron-variant
rs747732292 -- 19,085,084(+) AAATA(C/T)ACACA intron-variant
rs747758644 -- 19,105,221(+) GTGTT(A/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRG2 Gene

Variant ID Type Subtype PubMed ID
esv2660427 CNV deletion 23128226
esv2739998 CNV deletion 23290073
esv2752317 CNV gain 17911159
esv33517 CNV loss 17666407
esv3576793 CNV gain 25503493
nsv6823 CNV insertion 18451855

Variation tolerance for ADGRG2 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRG2 Gene

Disorders for ADGRG2 Gene

Relevant External Links for ADGRG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRG2

No disorders were found for ADGRG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRG2 Gene

Publications for ADGRG2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 65
  2. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. (PMID: 12420295) Obermann H. … Kirchhoff C. (Mol. Reprod. Dev. 2003) 3 4 22 65
  3. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. (PMID: 9150425) Osterhoff C. … Kirchhoff C. (DNA Cell Biol. 1997) 2 3 4 65
  4. Function of human epididymal proteins in sperm maturation. (PMID: 9739419) Kirchhoff C. … SchrAPter S. (Andrologia 1998) 2 3 65
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65

Products for ADGRG2 Gene

Sources for ADGRG2 Gene

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