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Aliases for ADGRG1 Gene

Aliases for ADGRG1 Gene

  • Adhesion G Protein-Coupled Receptor G1 2 3
  • TM7XN1 3 4 6
  • GPR56 3 4 6
  • G Protein-Coupled Receptor 56 2 3
  • TM7LN4 3 4
  • BFPP 3 6
  • 7-Transmembrane Protein With No EGF-Like N-Terminal Domains-1 3
  • G-Protein Coupled Receptor 56 3
  • Protein TM7XN1 4
  • BPPR 3

External Ids for ADGRG1 Gene

Previous HGNC Symbols for ADGRG1 Gene

  • GPR56

Summaries for ADGRG1 Gene

Entrez Gene Summary for ADGRG1 Gene

  • This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ADGRG1 Gene

ADGRG1 (Adhesion G Protein-Coupled Receptor G1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRG1 Gene

  • Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.

Gene Wiki entry for ADGRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRG1 Gene

Genomics for ADGRG1 Gene

Genomic Location for ADGRG1 Gene

Start:
57,610,652 bp from pter
End:
57,665,580 bp from pter
Size:
54,929 bases
Orientation:
Plus strand

Genomic View for ADGRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRG1 Gene

No data available for Regulatory Elements for ADGRG1 Gene

Proteins for ADGRG1 Gene

  • Protein details for ADGRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y653-GPR56_HUMAN
    Recommended name:
    G-protein coupled receptor 56
    Protein Accession:
    Q9Y653
    Secondary Accessions:
    • A6NIT7
    • A6NJV9
    • B0M0K4
    • B4DR54
    • O95966
    • Q6ZMP1
    • Q8NGB3
    • Q96HB4

    Protein attributes for ADGRG1 Gene

    Size:
    693 amino acids
    Molecular mass:
    77738 Da
    Quaternary structure:
    • Predominantly non-covalently linked heterodimer of the N-terminal and the C-terminal fragment. GPR56 NT self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. GPR56 CT interacts with ARRB2; the interaction is impaired by GPR56 NT. Interacts with TGM2; TGM2 probably is not a GPR56 ligand and the interaction is reported conflictingly (PubMed:16757564, PubMed:21349848). Part of a GPCR-tetraspanin complex at least consisting of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.

    Alternative splice isoforms for ADGRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRG1 Gene

Proteomics data for ADGRG1 Gene at MOPED

Post-translational modifications for ADGRG1 Gene

  • Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Shedding to yield the secreted GPR56 N-terminal fragment seems to involve metalloprotease(s).
  • N-glycosylated. Contains sialic acid residues.
  • Ubiquitinated. Undergoes polyubiquitination upon activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRG1 Gene

Domains for ADGRG1 Gene

Gene Families for ADGRG1 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry

Q9Y653

UniProtKB/Swiss-Prot:

GPR56_HUMAN :
  • Q9Y653
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRG1: view

No data available for Suggested Antigen Peptide Sequences for ADGRG1 Gene

Function for ADGRG1 Gene

Molecular function for ADGRG1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: GPR56 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic GPR56 NT interactions may relieve the inhibition.
UniProtKB/Swiss-Prot Function: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.

Gene Ontology (GO) - Molecular Function for ADGRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity ISS --
GO:0005518 collagen binding ISS --
GO:0050840 extracellular matrix binding ISS --
genes like me logo Genes that share ontologies with ADGRG1: view

Phenotypes for ADGRG1 Gene

genes like me logo Genes that share phenotypes with ADGRG1: view

miRNA for ADGRG1 Gene

miRTarBase miRNAs that target ADGRG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRG1 Gene

Localization for ADGRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRG1 Gene

Cell membrane; Multi-pass membrane protein.
GPR56 N-terminal fragment: Secreted.

Gene Ontology (GO) - Cellular Components for ADGRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10049584
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 15004227
GO:0070062 extracellular exosome IDA 23376485
GO:0097451 glial limiting end-foot ISS --
genes like me logo Genes that share ontologies with ADGRG1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRG1 Gene

Pathways for ADGRG1 Gene

SuperPathways for ADGRG1 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with ADGRG1: view

Pathways by source for ADGRG1 Gene

1 BioSystems pathway for ADGRG1 Gene

Interacting Proteins for ADGRG1 Gene

Selected Interacting proteins: Q9Y653-GPR56_HUMAN for ADGRG1 Gene via I2D

Symbol External ID(s) Details
ARRB2

Gene Ontology (GO) - Biological Process for ADGRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 21724588
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRG1: view

Transcripts for ADGRG1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRG1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRG1 Gene

No ASD Table

Relevant External Links for ADGRG1 Gene

GeneLoc Exon Structure for
ADGRG1
ECgene alternative splicing isoforms for
ADGRG1

Expression for ADGRG1 Gene

mRNA expression in normal human tissues for ADGRG1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRG1 Gene

mRNA Expression by UniProt/SwissProt for ADGRG1 Gene

Q9Y653-GPR56_HUMAN
Tissue specificity: Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.
genes like me logo Genes that share expressions with ADGRG1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADGRG1 Gene

Orthologs for ADGRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR56 35
  • 99.18 (n)
  • 98.54 (a)
GPR56 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
LOC509703 35
  • 89.11 (n)
  • 88.29 (a)
dog
(Canis familiaris)
Mammalia GPR56 35
  • 86.66 (n)
  • 84.86 (a)
GPR56 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr56 35
  • 81.64 (n)
  • 80.09 (a)
Gpr56 16
Gpr56 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR56 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR56 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr56 35
  • 81.34 (n)
  • 80.24 (a)
chicken
(Gallus gallus)
Aves GPR56 35
  • 59.82 (n)
  • 47.93 (a)
GPR56 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR56 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr56 35
  • 50.12 (n)
  • 39.47 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr56 36
  • 24 (a)
OneToMany
Species with no ortholog for ADGRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRG1 Gene

ENSEMBL:
Gene Tree for ADGRG1 (if available)
TreeFam:
Gene Tree for ADGRG1 (if available)

Paralogs for ADGRG1 Gene

genes like me logo Genes that share paralogs with ADGRG1: view

Variants for ADGRG1 Gene

Sequence variations from dbSNP and Humsavar for ADGRG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12641 -- 57,664,710(-) ACCAC(A/C)CTACA utr-variant-3-prime
rs15437 -- 57,664,885(-) CCCAT(A/C)TTCAA utr-variant-3-prime
rs733462 -- 57,648,593(-) AAAAG(A/G)AGGGG intron-variant
rs733463 -- 57,648,432(-) TAGGC(A/T)CATCA intron-variant
rs733464 -- 57,648,363(-) GAAGG(A/G)CACCA intron-variant

Relevant External Links for ADGRG1 Gene

HapMap Linkage Disequilibrium report
ADGRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRG1 Gene

Disorders for ADGRG1 Gene

(1) OMIM Diseases for ADGRG1 Gene (604110)

UniProtKB/Swiss-Prot

GPR56_HUMAN
  • Polymicrogyria, bilateral frontoparietal (BFPP) [MIM:606854]: A malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination, most severe in the frontoparietal regions. BFPP clinical manifestations include developmental and psychomotor delay, cerebellar and pyramidal signs, truncal ataxia, seizures, hyperreflexia. Polymicrogyria is a heterogeneous disorder, considered to be the result of postmigratory abnormal cortical organization. {ECO:0000269 PubMed:15044805, ECO:0000269 PubMed:16240336, ECO:0000269 PubMed:21723461}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Polymicrogyria, bilateral perisylvian, autosomal recessive (BPPR) [MIM:615752]: A form of polymicrogyria, a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. BPPR is characterized by strikingly restricted polymicrogyria limited to the cortex surrounding the Sylvian fissure. Affected individuals have intellectual and language difficulty and seizures, but no motor disability. Polymicrogyria is a heterogeneous disorder, considered to be the result of post-migratory abnormal cortical organization. {ECO:0000269 PubMed:24531968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Homozygous deletion of 1 of 2 tandem 15-bp repeats located 144 bp upstream of the GPR56 non-coding exon 1m transcription start site, results in impaired perisylvian GPR56 expression and disruption of perisylvian gyri (PubMed:24531968). {ECO:0000269 PubMed:24531968}.

(2) Novoseek inferred disease relationships for ADGRG1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4
cancer 0 5
genes like me logo Genes that share disorders with ADGRG1: view

Publications for ADGRG1 Gene

  1. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. (PMID: 15004227) Little K.D. … Stipp C.S. (Mol. Biol. Cell 2004) 3 4 23
  2. GPR56, a novel secretin-like human G-protein-coupled receptor gene. (PMID: 10049584) Liu M. … Herzog H. (Genomics 1999) 2 3 4
  3. TM7XN1, a novel human EGF-TM7 like protein, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. (PMID: 10100861) Zendman A.J.W. … van Muijen G.N.P. (FEBS Lett. 1999) 2 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. G protein-coupled receptor-dependent development of human frontal cortex. (PMID: 15044805) Piao X. … Walsh C.A. (Science 2004) 3 4

Products for ADGRG1 Gene

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