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Aliases for ADGRF5 Gene

Aliases for ADGRF5 Gene

  • Adhesion G Protein-Coupled Receptor F5 2 3 5
  • G Protein-Coupled Receptor 116 2 3
  • G-Protein Coupled Receptor 116 3 4
  • GPR116 3 4
  • Probable G-Protein Coupled Receptor 116 3
  • Ig-Hepta Homolog 3
  • KIAA0758 4
  • KPG_001 3

External Ids for ADGRF5 Gene

Previous HGNC Symbols for ADGRF5 Gene

  • GPR116

Summaries for ADGRF5 Gene

GeneCards Summary for ADGRF5 Gene

ADGRF5 (Adhesion G Protein-Coupled Receptor F5) is a Protein Coding gene. Among its related pathways are Surfactant metabolism and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG7.

UniProtKB/Swiss-Prot for ADGRF5 Gene

  • Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.

Gene Wiki entry for ADGRF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF5 Gene

Genomics for ADGRF5 Gene

Regulatory Elements for ADGRF5 Gene

Enhancers for ADGRF5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRF5 Gene

46,852,505 bp from pter
46,954,954 bp from pter
102,450 bases
Minus strand

Genomic View for ADGRF5 Gene

Genes around ADGRF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF5 Gene

Proteins for ADGRF5 Gene

  • Protein details for ADGRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor F5
    Protein Accession:
    Secondary Accessions:
    • O94858
    • Q5TF06
    • Q6RGN2
    • Q86SP0
    • Q9Y3Z2

    Protein attributes for ADGRF5 Gene

    1346 amino acids
    Molecular mass:
    149457 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N-terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD.
    • Sequence=BAA34478.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43394.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF5 Gene


neXtProt entry for ADGRF5 Gene

Proteomics data for ADGRF5 Gene at MOPED

Post-translational modifications for ADGRF5 Gene

  • Highly glycosylated.
  • Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin.
  • Glycosylation at Asn 73, Asn 94, Asn 106, Asn 188, Asn 256, Asn 272, Asn 301, Asn 315, Asn 328, Asn 398, Asn 472, Asn 487, Asn 505, Asn 540, Asn 627, Asn 649, Asn 666, Asn 820, Asn 931, Asn 963, and Asn 982
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRF5 Gene

Domains & Families for ADGRF5 Gene

Suggested Antigen Peptide Sequences for ADGRF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 1 GPS domain.
  • Contains 3 Ig-like (immunoglobulin-like) domains.
  • Contains 1 SEA domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF5: view

Function for ADGRF5 Gene

Molecular function for ADGRF5 Gene

UniProtKB/Swiss-Prot Function:
Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.
genes like me logo Genes that share phenotypes with ADGRF5: view

Animal Models for ADGRF5 Gene

MGI Knock Outs for ADGRF5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF5

miRNA for ADGRF5 Gene

miRTarBase miRNAs that target ADGRF5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRF5 Gene

Localization for ADGRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF5 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with ADGRF5: view

No data available for Subcellular locations from COMPARTMENTS for ADGRF5 Gene

Pathways & Interactions for ADGRF5 Gene

genes like me logo Genes that share pathways with ADGRF5: view

Pathways by source for ADGRF5 Gene

1 BioSystems pathway for ADGRF5 Gene
2 Reactome pathways for ADGRF5 Gene

Interacting Proteins for ADGRF5 Gene

Gene Ontology (GO) - Biological Process for ADGRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0042593 glucose homeostasis IEA --
GO:0043031 negative regulation of macrophage activation IEA --
genes like me logo Genes that share ontologies with ADGRF5: view

No data available for SIGNOR curated interactions for ADGRF5 Gene

Drugs & Compounds for ADGRF5 Gene

No Compound Related Data Available

Transcripts for ADGRF5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: -

ExUns: 25b · 25c

Relevant External Links for ADGRF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRF5 Gene

mRNA expression in normal human tissues for ADGRF5 Gene

Protein differential expression in normal tissues from HIPED for ADGRF5 Gene

This gene is overexpressed in Serum (54.9) and Plasma (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRF5 Gene

genes like me logo Genes that share expression patterns with ADGRF5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADGRF5 Gene

Orthologs for ADGRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR116 35
  • 81.42 (n)
  • 74.96 (a)
GPR116 36
  • 75 (a)
(Canis familiaris)
Mammalia GPR116 35
  • 84.52 (n)
  • 79.79 (a)
GPR116 36
  • 78 (a)
(Mus musculus)
Mammalia Gpr116 35
  • 78.05 (n)
  • 72.17 (a)
Adgrf5 16
Gpr116 36
  • 72 (a)
(Pan troglodytes)
Mammalia GPR116 35
  • 99.43 (n)
  • 99.33 (a)
GPR116 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gpr116 35
  • 78.3 (n)
  • 73.1 (a)
(Monodelphis domestica)
Mammalia GPR116 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia GPR116 36
  • 60 (a)
(Gallus gallus)
Aves GPR116 35
  • 55.4 (n)
  • 44.82 (a)
GPR116 36
  • 43 (a)
(Anolis carolinensis)
Reptilia GPR116 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr116 35
  • 50.25 (n)
  • 39.06 (a)
(Danio rerio)
Actinopterygii si:dkey-30j22.5 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for ADGRF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF5 Gene

Gene Tree for ADGRF5 (if available)
Gene Tree for ADGRF5 (if available)

Paralogs for ADGRF5 Gene

Paralogs for ADGRF5 Gene Pseudogenes for ADGRF5 Gene

genes like me logo Genes that share paralogs with ADGRF5: view

Variants for ADGRF5 Gene

Sequence variations from dbSNP and Humsavar for ADGRF5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs547499 - 46,859,336(-) CAGCA(C/T)GGTAA reference, missense
rs586024 - 46,866,948(-) CCATA(C/T)GGGTT reference, missense
rs9395218 - 46,859,502(+) GATGA(C/T)ATTAA reference, missense
rs1045791 -- 46,852,887(-) GGATA(A/C)TGGCC utr-variant-3-prime
rs1234117 -- 46,953,718(-) ATATG(C/T)AATTC intron-variant

Variation tolerance for ADGRF5 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRF5 Gene

Disorders for ADGRF5 Gene

Relevant External Links for ADGRF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF5 Gene

Publications for ADGRF5 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 3
  3. Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. (PMID: 23684610) Yang M.Y. … St Croix B. (Cell Rep 2013) 3
  4. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the GI+q-p63RhoGEF-Rho GTPase pathway. (PMID: 24008316) Tang X. … Luo J. (Cancer Res. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ADGRF5 Gene

Sources for ADGRF5 Gene