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Aliases for ADGRF2 Gene

Aliases for ADGRF2 Gene

  • Adhesion G Protein-Coupled Receptor F2 2 3 5
  • G Protein-Coupled Receptor 111 2 3
  • GPR111 3 4
  • PGR20 3 4
  • Probable G-Protein Coupled Receptor 111 3
  • G-Protein Coupled Receptor PGR20 4
  • G-Protein Coupled Receptor 111 4
  • HGPCR35 3

External Ids for ADGRF2 Gene

Previous HGNC Symbols for ADGRF2 Gene

  • GPR111

Summaries for ADGRF2 Gene

GeneCards Summary for ADGRF2 Gene

ADGRF2 (Adhesion G Protein-Coupled Receptor F2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG7.

UniProtKB/Swiss-Prot for ADGRF2 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF2 Gene

Genomics for ADGRF2 Gene

Regulatory Elements for ADGRF2 Gene

Enhancers for ADGRF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRF2 Gene

Chromosome:
6
Start:
47,656,436 bp from pter
End:
47,697,797 bp from pter
Size:
41,362 bases
Orientation:
Plus strand

Genomic View for ADGRF2 Gene

Genes around ADGRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF2 Gene

Proteins for ADGRF2 Gene

  • Protein details for ADGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZF7-AGRF2_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor F2
    Protein Accession:
    Q8IZF7
    Secondary Accessions:
    • Q2PNZ1
    • Q86SL6
    • Q8NGU5
    • Q8TDT5

    Protein attributes for ADGRF2 Gene

    Size:
    708 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.
    SequenceCaution:
    • Sequence=BAC05907.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRF2 Gene

Proteomics data for ADGRF2 Gene at MOPED

Post-translational modifications for ADGRF2 Gene

  • Glycosylation at Asn 21, Asn 220, Asn 252, Asn 260, Asn 305, Asn 313, and Asn 358
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRF2 Gene

No data available for DME Specific Peptides for ADGRF2 Gene

Domains & Families for ADGRF2 Gene

Gene Families for ADGRF2 Gene

Protein Domains for ADGRF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZF7

UniProtKB/Swiss-Prot:

AGRF2_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF2: view

Function for ADGRF2 Gene

Molecular function for ADGRF2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with ADGRF2: view

Animal Models for ADGRF2 Gene

MGI Knock Outs for ADGRF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF2 Gene

Localization for ADGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRF2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRF2 Gene

Pathways & Interactions for ADGRF2 Gene

SuperPathways for ADGRF2 Gene

No Data Available

Interacting Proteins for ADGRF2 Gene

Gene Ontology (GO) - Biological Process for ADGRF2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRF2 Gene

Drugs & Compounds for ADGRF2 Gene

No Compound Related Data Available

Transcripts for ADGRF2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF2 Gene

No ASD Table

Relevant External Links for ADGRF2 Gene

GeneLoc Exon Structure for
ADGRF2
ECgene alternative splicing isoforms for
ADGRF2

Expression for ADGRF2 Gene

mRNA expression in normal human tissues for ADGRF2 Gene

mRNA Expression by UniProt/SwissProt for ADGRF2 Gene

Q8IZF7-AGRF2_HUMAN
Tissue specificity: High expression in kidney. Up-regulated in lung adenocarcinomas and prostate cancers.
genes like me logo Genes that share expression patterns with ADGRF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ADGRF2 Gene

Orthologs for ADGRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR111 35
  • 82.29 (n)
  • 79.72 (a)
GPR111 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR111 35
  • 85.77 (n)
  • 85.51 (a)
GPR111 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr111 35
  • 78.86 (n)
  • 76.11 (a)
Adgrf2 16
Gpr111 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR111 35
  • 99.38 (n)
  • 98.75 (a)
GPR111 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr111 35
  • 79.05 (n)
  • 76.71 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR111 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR111 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX545917.1 36
  • 27 (a)
ManyToMany
CABZ01002470.1 36
  • 36 (a)
ManyToMany
si:dkey-13i15.1 36
  • 11 (a)
ManyToMany
si:dkey-30j22.12 36
  • 22 (a)
ManyToMany
si:dkey-30j22.2 36
  • 20 (a)
ManyToMany
si:dkey-30j22.4 36
  • 25 (a)
ManyToMany
Species with no ortholog for ADGRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF2 Gene

ENSEMBL:
Gene Tree for ADGRF2 (if available)
TreeFam:
Gene Tree for ADGRF2 (if available)

Paralogs for ADGRF2 Gene

Paralogs for ADGRF2 Gene

genes like me logo Genes that share paralogs with ADGRF2: view

Variants for ADGRF2 Gene

Sequence variations from dbSNP and Humsavar for ADGRF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6907125 - 47,679,106(+) CTGCC(A/G)GACTC reference, missense
rs9381594 - 47,681,958(+) TGTCC(A/G)TTGAG reference, missense
rs1021231 -- 47,656,897(+) TTTAC(A/G)TAATA intron-variant
rs1026979 -- 47,655,949(+) aggga(C/G)taaga upstream-variant-2KB
rs1026980 -- 47,657,252(+) ACATT(C/T)TTCTT intron-variant

Variation tolerance for ADGRF2 Gene

Gene Damage Index Score: 11.42; 92.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRF2 Gene

Disorders for ADGRF2 Gene

Relevant External Links for ADGRF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRF2

No disorders were found for ADGRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF2 Gene

Publications for ADGRF2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2002) 2 3
  3. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3
  4. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 3
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3

Products for ADGRF2 Gene

Sources for ADGRF2 Gene

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