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ADGRF1 Gene(Protein Coding)

Adhesion G Protein-Coupled Receptor F1

GCID:
GC06M046997
GIFtS:
38
Genes Participants
UDN Logo

Aliases for ADGRF1 Gene

Aliases for ADGRF1 Gene

  • Adhesion G Protein-Coupled Receptor F1 2 3 5
  • G Protein-Coupled Receptor 110 2 3 4
  • G Protein-Coupled Receptor PGR19 3 4
  • GPR110 3 4
  • PGR19 3 4
  • Probable G-Protein Coupled Receptor 110 3
  • Adhesion G-Protein Coupled Receptor F1 3
  • Seven Transmembrane Helix Receptor 3
  • G-Protein Coupled Receptor KPG_012 3
  • G Protein-Coupled Receptor KPG_012 4
  • KPG_012 3
  • HGPCR36 3

External Ids for ADGRF1 Gene

Previous HGNC Symbols for ADGRF1 Gene

  • GPR110

Summaries for ADGRF1 Gene

GeneCards Summary for ADGRF1 Gene

ADGRF1 (Adhesion G Protein-Coupled Receptor F1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF5.

UniProtKB/Swiss-Prot for ADGRF1 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRF1 Gene

Additional gene information for ADGRF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF1 Gene

Genomics for ADGRF1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ADGRF1 Gene

Promoters and enhancers for ADGRF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06I047041 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 555.7 -1.2 -1246 4.6 ELF3 JUN RFX5 ZNF316 GATA3 POLR2A FOS FOSL2 MAFK CEBPB ADGRF1 LOC105375081
GH06I047034 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.1 +7.2 7197 1.6 PKNOX1 FEZF1 ZNF2 ZNF121 ZNF213 DEK ZNF202 TSHZ1 ZNF518A ZNF610 PLA2G7 ADGRF1 ADGRF5
GH06I047092 Enhancer 1.1 Ensembl ENCODE 4.6 -51.3 -51304 3.3 CLOCK FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 SLC30A9 SP5 MXD4 ADGRF1 LOC105375081
GH06I047083 Enhancer 0.9 ENCODE 4.6 -41.6 -41612 1.7 PKNOX1 FOXA2 ARID4B FEZF1 ZNF2 ZNF48 RXRA MXD4 TSHZ1 NFIL3 TNFRSF21 PLA2G7 ADGRF1 LOC105375081
GH06I047046 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -5.2 -5244 1.6 ATF1 CLOCK FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 GATA2 ZNF143 TNFRSF21 ADGRF5 PLA2G7 ADGRF1 LOC105375081
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRF1 Gene

Genomic Locations for ADGRF1 Gene
chr6:46,997,703-47,042,363
(GRCh38/hg38)
Size:
44,661 bases
Orientation:
Minus strand
chr6:46,965,440-47,010,099
(GRCh37/hg19)

Genomic View for ADGRF1 Gene

Genes around ADGRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRF1 Gene

Proteins for ADGRF1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T601-AGRF1_HUMAN
    Recommended name:
    Adhesion G-protein coupled receptor F1
    Protein Accession:
    Q5T601
    Secondary Accessions:
    • Q5KU15
    • Q5T5Z9
    • Q5T600
    • Q86SM1
    • Q8IXE3
    • Q8IZF8
    • Q96DQ1
    • Q9H615

    Protein attributes for ADGRF1 Gene

    Size:
    910 amino acids
    Molecular mass:
    101365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB70874.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAC45260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRF1 Gene

Protein Expression for ADGRF1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRF1 Gene

  • Glycosylated.
  • Glycosylation at posLast=139139, Asn168, Asn205, Asn282, posLast=310310, posLast=317317, Asn329, Asn354, posLast=368368, posLast=389389, Asn410, posLast=423423, Asn437, posLast=455455, Asn512, posLast=528528, posLast=553553, posLast=736736, and Asn739

Other Protein References for ADGRF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRF1 Gene

Domains & Families for ADGRF1 Gene

Gene Families for ADGRF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ADGRF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T601

UniProtKB/Swiss-Prot:

AGRF1_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF1: view

Function for ADGRF1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ADGRF1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRF1: view
genes like me logo Genes that share phenotypes with ADGRF1: view

Animal Models for ADGRF1 Gene

MGI Knock Outs for ADGRF1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF1 Gene

Localization for ADGRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF1 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF1 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF1 Gene

Pathways & Interactions for ADGRF1 Gene

SuperPathways for ADGRF1 Gene

PathCards logo More details on SuperPathways for ADGRF1
No Data Available

Interacting Proteins for ADGRF1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360299%0d%0a9606.ENSP00000429430%0d%0a9606.ENSP00000385276%0d%0a9606.ENSP00000403954%0d%0a9606.ENSP00000263525%0d%0a9606.ENSP00000239462%0d%0a
Selected Interacting proteins: ENSP00000360299 for ADGRF1 Gene via STRING

Gene Ontology (GO) - Biological Process for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA 15203201
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007416 synapse assembly IEA --
genes like me logo Genes that share ontologies with ADGRF1: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF1 Gene

Drugs & Compounds for ADGRF1 Gene

Products:

  1. Drug

(1) Drugs for ADGRF1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ronacaleret Investigational Pharma Target 0
genes like me logo Genes that share compounds with ADGRF1: view

Transcripts for ADGRF1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADGRF1 Gene

(5) REFSEQ mRNAs :
(67) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF1 Gene

No ASD Table

Relevant External Links for ADGRF1 Gene

GeneLoc Exon Structure for
ADGRF1
ECgene alternative splicing isoforms for
ADGRF1

Expression for ADGRF1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRF1 Gene

mRNA expression in normal human tissues for ADGRF1 Gene
mRNA expression by GTEx for ADGRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRF1 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRF1 Gene



Protein tissue co-expression partners for ADGRF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRF1 Gene:

ADGRF1

mRNA Expression by UniProt/SwissProt for ADGRF1 Gene:

Q5T601-AGRF1_HUMAN
Tissue specificity: Mainly expressed in the kidney. Up-regulated in lung adenocarcinomas and prostate cancers.

Evidence on tissue expression from TISSUES for ADGRF1 Gene

  • Intestine(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ADGRF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF1 Gene

Orthologs for ADGRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR110 34 33
  • 99.19 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPR110 34 33
  • 85.16 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia GPR110 34 33
  • 79.34 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gpr110 33
  • 78.38 (n)
mouse
(Mus musculus)
 Mammalia Gpr110 34 33
  • 78.28 (n)
 OneToOne
Adgrf1 16
oppossum
(Monodelphis domestica)
 Mammalia GPR110 34
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GPR110 34
  • 60 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.16436 33
zebrafish
(Danio rerio)
 Actinopterygii CABZ01002470.1 34
  • 43 (a)
 ManyToMany
BX545917.1 34
  • 34 (a)
 ManyToMany
si:dkey-30j22.4 34
  • 32 (a)
 ManyToMany
si:dkey-30j22.12 34
  • 27 (a)
 ManyToMany
si:dkey-30j22.2 34
  • 27 (a)
 ManyToMany
si:dkey-13i15.1 34
  • 15 (a)
 ManyToMany
Species where no ortholog for ADGRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF1 Gene

ENSEMBL:
Gene Tree for ADGRF1 (if available)
TreeFam:
Gene Tree for ADGRF1 (if available)

Paralogs for ADGRF1 Gene

Paralogs for ADGRF1 Gene

genes like me logo Genes that share paralogs with ADGRF1: view

Variants for ADGRF1 Gene

Sequence variations from dbSNP and Humsavar for ADGRF1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000161532 -- 47,037,787(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000168076 -- 47,012,439(-) TTTT/TTT genic_downstream_transcript_variant, intron_variant
rs1000302832 -- 47,009,744(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000335309 -- 47,044,086(-) T/C upstream_transcript_variant
rs1000338908 -- 46,997,626(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRF1 Gene

Variant ID Type Subtype PubMed ID
esv2732032 CNV deletion 23290073
esv3608891 CNV loss 21293372
nsv1017113 CNV gain 25217958
nsv1140369 OTHER inversion 24896259

Variation tolerance for ADGRF1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRF1 Gene

Human Gene Mutation Database (HGMD)
ADGRF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF1 Gene

Disorders for ADGRF1 Gene

Additional Disease Information for ADGRF1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADGRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF1 Gene

Publications for ADGRF1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 58
  3. Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. (PMID: 20149256) Lum AM … Wabl M (BMC cancer 2010) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 58

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Sources for ADGRF1 Gene

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