Aliases for ADGRF1 Gene
Aliases for ADGRF1 Gene
External Ids for ADGRF1 Gene
- HGNC: 18990
- Entrez Gene: 266977
- Ensembl: ENSG00000153292
- OMIM: 617430
- UniProtKB: Q5T601
Previous HGNC Symbols for ADGRF1 Gene
- GPR110
Summaries for ADGRF1 Gene
GeneCards Summary for ADGRF1 Gene
ADGRF1 (Adhesion G Protein-Coupled Receptor F1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF5.
UniProtKB/Swiss-Prot for ADGRF1 Gene
-
Orphan receptor.
Additional gene information for ADGRF1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF1 Gene
Genomics for ADGRF1 Gene
GeneHancer (GH) Regulatory Elements for ADGRF1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06I047041 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE dbSUPER | 555.7 | -1.2 | -1246 | 4.6 | ELF3 JUN RFX5 ZNF316 GATA3 POLR2A FOS FOSL2 MAFK CEBPB | ADGRF1 LOC105375081 | |
GH06I047034 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 5.1 | +7.2 | 7197 | 1.6 | PKNOX1 FEZF1 ZNF2 ZNF121 ZNF213 DEK ZNF202 TSHZ1 ZNF518A ZNF610 | PLA2G7 ADGRF1 ADGRF5 | |
GH06I047092 | Enhancer | 1.1 | Ensembl ENCODE | 4.6 | -51.3 | -51304 | 3.3 | CLOCK FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF48 SLC30A9 SP5 MXD4 | ADGRF1 LOC105375081 | |
GH06I047083 | Enhancer | 0.9 | ENCODE | 4.6 | -41.6 | -41612 | 1.7 | PKNOX1 FOXA2 ARID4B FEZF1 ZNF2 ZNF48 RXRA MXD4 TSHZ1 NFIL3 | TNFRSF21 PLA2G7 ADGRF1 LOC105375081 | |
GH06I047046 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 0.4 | -5.2 | -5244 | 1.6 | ATF1 CLOCK FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 GATA2 ZNF143 | TNFRSF21 ADGRF5 PLA2G7 ADGRF1 LOC105375081 |
Regulatory Element Products
Genomic Locations for ADGRF1 Gene
- chr6:46,997,703-47,042,363
- (GRCh38/hg38)
- Size:
- 44,661 bases
- Orientation:
- Minus strand
- chr6:46,965,440-47,010,099
- (GRCh37/hg19)
Genomic View for ADGRF1 Gene
- Cytogenetic band:
-
- 6p12.3 by Ensembl
- 6p12.3|6 by Entrez Gene
- 6p12.3 by HGNC


RefSeq DNA sequence for ADGRF1 Gene
Proteins for ADGRF1 Gene
-
Protein details for ADGRF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T601-AGRF1_HUMAN
- Recommended name:
- Adhesion G-protein coupled receptor F1
- Protein Accession:
- Q5T601
- Q5KU15
- Q5T5Z9
- Q5T600
- Q86SM1
- Q8IXE3
- Q8IZF8
- Q96DQ1
- Q9H615
Protein attributes for ADGRF1 Gene
- Size:
- 910 amino acids
- Molecular mass:
- 101365 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB70874.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAC45260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for ADGRF1 Gene
Post-translational modifications for ADGRF1 Gene
- Glycosylated.
- Glycosylation at posLast=139139, Asn168, Asn205, Asn282, posLast=310310, posLast=317317, Asn329, Asn354, posLast=368368, posLast=389389, Asn410, posLast=423423, Asn437, posLast=455455, Asn512, posLast=528528, posLast=553553, posLast=736736, and Asn739
Other Protein References for ADGRF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
-
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Abcam proteins for ADGRF1
Assay Products
No data available for DME Specific Peptides for ADGRF1 Gene
Domains & Families for ADGRF1 Gene
Gene Families for ADGRF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ADGRF1 Gene
Suggested Antigen Peptide Sequences for ADGRF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5T601UniProtKB/Swiss-Prot:
AGRF1_HUMAN :- Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Function for ADGRF1 Gene
Molecular function for ADGRF1 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
Phenotypes for ADGRF1 Gene
- MGI mutant phenotypes for ADGRF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADGRF1:
-
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased Dengue Infection
- Increased Nanog expression
Animal Models for ADGRF1 Gene
- MGI Knock Outs for ADGRF1:
-
- Adgrf1 tm1Tcam
Animal Model Products
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-
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADGRF1
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Horizon Cell Lines for ADGRF1
-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF1 Gene
Localization for ADGRF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADGRF1 Gene
- Cell membrane; Multi-pass membrane protein.
- Isoform 2: Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005622 | intracellular | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF1 Gene
Pathways & Interactions for ADGRF1 Gene
Interacting Proteins for ADGRF1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS,IEA | 15203201 |
GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | IEA | -- |
GO:0007416 | synapse assembly | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ADGRF1 Gene
Drugs & Compounds for ADGRF1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ronacaleret | Investigational | Pharma | Target | 0 |
Transcripts for ADGRF1 Gene
mRNA/cDNA for ADGRF1 Gene
- (5) REFSEQ mRNAs :
- (67) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADGRF1
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Recommended
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-
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADGRF1
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Recommended
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADGRF1
- genomics-online: cdna clones - Search results for 76 available GPR110 gene related products
- Overview of 76 available GPR110 gene related products
-
Recommended
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- Overview of 76 available GPR110 gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Expression for ADGRF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADGRF1 Gene:
ADGRF1mRNA Expression by UniProt/SwissProt for ADGRF1 Gene:
Q5T601-AGRF1_HUMANEvidence on tissue expression from TISSUES for ADGRF1 Gene
- Intestine(4.1)
- Lung(4.1)
Primer Products
-
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-
OriGene qPCR primer pairs for ADGRF1
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Recommended
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF1 Gene
Orthologs for ADGRF1 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPR110 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | GPR110 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | GPR110 34 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Gpr110 33 |
|
||
mouse (Mus musculus) |
Mammalia | Gpr110 34 33 |
|
OneToOne | |
Adgrf1 16 |
|
||||
oppossum (Monodelphis domestica) |
Mammalia | GPR110 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | GPR110 34 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16436 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | CABZ01002470.1 34 |
|
ManyToMany | |
BX545917.1 34 |
|
ManyToMany | |||
si:dkey-30j22.4 34 |
|
ManyToMany | |||
si:dkey-30j22.12 34 |
|
ManyToMany | |||
si:dkey-30j22.2 34 |
|
ManyToMany | |||
si:dkey-13i15.1 34 |
|
ManyToMany |
- Species where no ortholog for ADGRF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ADGRF1 Gene
Variants for ADGRF1 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000161532 | -- | 47,037,787(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
rs1000168076 | -- | 47,012,439(-) | TTTT/TTT | genic_downstream_transcript_variant, intron_variant | |
rs1000302832 | -- | 47,009,744(-) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
rs1000335309 | -- | 47,044,086(-) | T/C | upstream_transcript_variant | |
rs1000338908 | -- | 46,997,626(-) | C/T | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2732032 | CNV | deletion | 23290073 |
esv3608891 | CNV | loss | 21293372 |
nsv1017113 | CNV | gain | 25217958 |
nsv1140369 | OTHER | inversion | 24896259 |
Additional Variant Information for ADGRF1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF1 Gene
Disorders for ADGRF1 Gene
Additional Disease Information for ADGRF1
No disorders were found for ADGRF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF1 Gene
Publications for ADGRF1 Gene
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
- Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 58
- Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. (PMID: 20149256) Lum AM … Wabl M (BMC cancer 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 58
Products for ADGRF1 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ADGRF1
- antibodies-online: Search results for 57 available GPR110 Antibodies ranked by validation data
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- antibodies-online: Search results for available GPR110 related products ranked by validation data
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Sources for ADGRF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew