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Aliases for ADGRF1 Gene

Aliases for ADGRF1 Gene

  • Adhesion G Protein-Coupled Receptor F1 2 3 5
  • G Protein-Coupled Receptor 110 2 3 4
  • G Protein-Coupled Receptor PGR19 3 4
  • GPR110 3 4
  • PGR19 3 4
  • Probable G-Protein Coupled Receptor 110 3
  • Adhesion G-Protein Coupled Receptor F1 3
  • Seven Transmembrane Helix Receptor 3
  • G-Protein Coupled Receptor KPG_012 3
  • G Protein-Coupled Receptor KPG_012 4
  • KPG_012 3
  • HGPCR36 3

External Ids for ADGRF1 Gene

Previous HGNC Symbols for ADGRF1 Gene

  • GPR110

Summaries for ADGRF1 Gene

GeneCards Summary for ADGRF1 Gene

ADGRF1 (Adhesion G Protein-Coupled Receptor F1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRF5.

UniProtKB/Swiss-Prot for ADGRF1 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRF1 Gene

Additional gene information for ADGRF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRF1 Gene

Genomics for ADGRF1 Gene

Regulatory Elements for ADGRF1 Gene

Enhancers for ADGRF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H047041 1.3 Ensembl ENCODE dbSUPER 5.7 -1.2 -1246 4.6 GTF2F1 ELF3 TBP TAL1 JUN RFX5 GATA3 ZNF316 POLR2A FOSL2 ADGRF1 LOC105375081
GH06H047034 1.4 Ensembl ENCODE dbSUPER 5.1 +7.2 7198 1.6 PKNOX1 FEZF1 ZNF2 ZNF121 DEK ZNF202 TSHZ1 ZNF518A ZNF610 ZSCAN16 PLA2G7 ADGRF1 ADGRF5
GH06H047092 1.2 Ensembl ENCODE 4.6 -51.3 -51304 3.3 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 SLC30A9 SP5 MXD4 MIER2 ADGRF1 LOC105375081
GH06H047083 0.9 ENCODE 4.6 -41.6 -41613 1.7 ELF3 PKNOX1 FOXA2 ARID4B FEZF1 ZNF2 THRB RAD21 RCOR1 THAP11 TNFRSF21 PLA2G7 ADGRF1 LOC105375081
GH06H047046 1.5 Ensembl ENCODE dbSUPER 0.4 -5.2 -5245 1.6 FOXA2 ATF1 ARID4B SIN3A FEZF1 ZNF2 YY1 GATA2 ZNF143 FOS TNFRSF21 ADGRF5 PLA2G7 ADGRF1 LOC105375081
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRF1 Gene

Genomic Locations for ADGRF1 Gene
44,661 bases
Minus strand

Genomic View for ADGRF1 Gene

Genes around ADGRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRF1 Gene

Proteins for ADGRF1 Gene

  • Protein details for ADGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor F1
    Protein Accession:
    Secondary Accessions:
    • Q5KU15
    • Q5T5Z9
    • Q5T600
    • Q86SM1
    • Q8IXE3
    • Q8IZF8
    • Q96DQ1
    • Q9H615

    Protein attributes for ADGRF1 Gene

    910 amino acids
    Molecular mass:
    101365 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70874.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAC45260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRF1 Gene


neXtProt entry for ADGRF1 Gene

Post-translational modifications for ADGRF1 Gene

  • Glycosylated.
  • Glycosylation at Asn139, Asn168, posLast=205205, posLast=282282, posLast=310310, Asn317, posLast=329329, posLast=354354, posLast=368368, posLast=389389, Asn410, Asn423, Asn437, posLast=455455, Asn512, Asn528, posLast=553553, posLast=736736, and posLast=739739
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRF1 Gene

Domains & Families for ADGRF1 Gene

Gene Families for ADGRF1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADGRF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRF1: view

Function for ADGRF1 Gene

Molecular function for ADGRF1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRF1: view
genes like me logo Genes that share phenotypes with ADGRF1: view

Animal Models for ADGRF1 Gene

MGI Knock Outs for ADGRF1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRF1 Gene

Localization for ADGRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRF1 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRF1 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRF1 Gene

Pathways & Interactions for ADGRF1 Gene

SuperPathways for ADGRF1 Gene

No Data Available

Interacting Proteins for ADGRF1 Gene

Gene Ontology (GO) - Biological Process for ADGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRF1: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRF1 Gene

Drugs & Compounds for ADGRF1 Gene

(1) Drugs for ADGRF1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ronacaleret Investigational Pharma Target 0
genes like me logo Genes that share compounds with ADGRF1: view

Transcripts for ADGRF1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRF1 Gene

No ASD Table

Relevant External Links for ADGRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRF1 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRF1 Gene

Protein tissue co-expression partners for ADGRF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRF1 Gene:


mRNA Expression by UniProt/SwissProt for ADGRF1 Gene:

Tissue specificity: Mainly expressed in the kidney. Up-regulated in lung adenocarcinomas and prostate cancers.

Evidence on tissue expression from TISSUES for ADGRF1 Gene

  • Intestine(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ADGRF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRF1 Gene

Orthologs for ADGRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR110 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia GPR110 34 33
  • 85.16 (n)
(Bos Taurus)
Mammalia GPR110 34 33
  • 79.34 (n)
(Rattus norvegicus)
Mammalia Gpr110 33
  • 78.38 (n)
(Mus musculus)
Mammalia Gpr110 34 33
  • 78.28 (n)
Adgrf1 16
(Monodelphis domestica)
Mammalia GPR110 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia GPR110 34
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16436 33
(Danio rerio)
Actinopterygii CABZ01002470.1 34
  • 43 (a)
BX545917.1 34
  • 34 (a)
si:dkey-30j22.4 34
  • 32 (a)
si:dkey-30j22.2 34
  • 27 (a)
si:dkey-30j22.12 34
  • 27 (a)
si:dkey-13i15.1 34
  • 15 (a)
Species where no ortholog for ADGRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRF1 Gene

Gene Tree for ADGRF1 (if available)
Gene Tree for ADGRF1 (if available)

Paralogs for ADGRF1 Gene

Paralogs for ADGRF1 Gene

genes like me logo Genes that share paralogs with ADGRF1: view

Variants for ADGRF1 Gene

Sequence variations from dbSNP and Humsavar for ADGRF1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000161532 -- 47,037,787(+) AGATT(G/T)CAGGT intron-variant
rs1000168076 -- 47,012,439(+) TATTA(-/T)TTTCA intron-variant
rs1000302832 -- 47,009,744(+) AGTGA(A/G)TACAT reference, missense
rs1000335309 -- 47,044,086(+) TTCAC(C/T)GACAT upstream-variant-2KB
rs1000338908 -- 46,997,626(+) ATATG(C/T)AGCAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ADGRF1 Gene

Variant ID Type Subtype PubMed ID
nsv1140369 OTHER inversion 24896259
nsv1017113 CNV gain 25217958
esv3608891 CNV loss 21293372
esv2732032 CNV deletion 23290073

Variation tolerance for ADGRF1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRF1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRF1 Gene

Disorders for ADGRF1 Gene

Relevant External Links for ADGRF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRF1 Gene

Publications for ADGRF1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 60
  2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PMID: 12435584) Fredriksson R … Schiöth HB (FEBS letters 2002) 2 3 4 60
  3. Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. (PMID: 20149256) Lum AM … Wabl M (BMC cancer 2010) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 60

Products for ADGRF1 Gene

Sources for ADGRF1 Gene

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