Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRE5 Gene

Aliases for ADGRE5 Gene

  • Adhesion G Protein-Coupled Receptor E5 2 3
  • Leukocyte Antigen CD97 2 3 4
  • Seven Transmembrane Helix Receptor 2 3
  • Seven-Span Transmembrane Protein 2 3
  • CD97 Molecule 2 3
  • CD97 Antigen 2 4
  • Seven-Transmembrane, Heterodimeric Receptor Associated With Inflammation 3
  • Heterodimeric Receptor Associated With Inflammation 2
  • Seven-Transmembrane 2
  • TM7LN1 3
  • CD97 3

External Ids for ADGRE5 Gene

Previous HGNC Symbols for ADGRE5 Gene

  • CD97

Summaries for ADGRE5 Gene

Entrez Gene Summary for ADGRE5 Gene

  • This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

GeneCards Summary for ADGRE5 Gene

ADGRE5 (Adhesion G Protein-Coupled Receptor E5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRE5 Gene

  • Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).

Gene Wiki entry for ADGRE5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE5 Gene

Genomics for ADGRE5 Gene

Genomic Location for ADGRE5 Gene

Chromosome:
19
Start:
14,380,501 bp from pter
End:
14,408,725 bp from pter
Size:
28,225 bases
Orientation:
Plus strand

Genomic View for ADGRE5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE5 Gene

No data available for Regulatory Elements for ADGRE5 Gene

Proteins for ADGRE5 Gene

  • Protein details for ADGRE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48960-CD97_HUMAN
    Recommended name:
    CD97 antigen
    Protein Accession:
    P48960
    Secondary Accessions:
    • A8K7Z4
    • B2RBJ9
    • O00718
    • O76101
    • Q8NG72
    • Q8TBQ7

    Protein attributes for ADGRE5 Gene

    Size:
    835 amino acids
    Molecular mass:
    91869 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.
    SequenceCaution:
    • Sequence=AAC27673.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC06178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRE5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE5 Gene

Proteomics data for ADGRE5 Gene at MOPED

Post-translational modifications for ADGRE5 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRE5 Gene

No data available for DME Specific Peptides for ADGRE5 Gene

Domains & Families for ADGRE5 Gene

Suggested Antigen Peptide Sequences for ADGRE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48960

UniProtKB/Swiss-Prot:

CD97_HUMAN :
  • The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region
  • Binding to chondroitin sulfate is mediated by the fourth EGF domain
  • Contains 5 EGF-like domains.
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRE5: view

Function for ADGRE5 Gene

Molecular function for ADGRE5 Gene

UniProtKB/Swiss-Prot Function:
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).
UniProtKB/Swiss-Prot Induction:
Rapid up-regulation during lymphocyte activation

Gene Ontology (GO) - Molecular Function for ADGRE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 7636245
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9064337
genes like me logo Genes that share ontologies with ADGRE5: view
genes like me logo Genes that share phenotypes with ADGRE5: view

Animal Models for ADGRE5 Gene

MGI Knock Outs for ADGRE5:

Animal Model Products

miRNA for ADGRE5 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRE5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADGRE5 Gene

Localization for ADGRE5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE5 Gene

Cell membrane; Multi-pass membrane protein.
CD97 antigen subunit alpha: Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for ADGRE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8955192
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ADGRE5: view

No data available for Subcellular locations from COMPARTMENTS for ADGRE5 Gene

Pathways & Interactions for ADGRE5 Gene

genes like me logo Genes that share pathways with ADGRE5: view

Pathways by source for ADGRE5 Gene

SIGNOR curated interactions for ADGRE5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADGRE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 7636245
GO:0006954 inflammatory response TAS 8955192
GO:0006955 immune response TAS 7636245
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRE5: view

Drugs & Compounds for ADGRE5 Gene

(1) Drugs for ADGRE5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chondroitin Nutra 40

(4) Additional Compounds for ADGRE5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
9007-28-7
DERMATAN SULFATE
retinoic acid
302-79-4
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with ADGRE5: view

Transcripts for ADGRE5 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRE5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6: -

Relevant External Links for ADGRE5 Gene

GeneLoc Exon Structure for
ADGRE5
ECgene alternative splicing isoforms for
ADGRE5

Expression for ADGRE5 Gene

mRNA expression in normal human tissues for ADGRE5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRE5 Gene

This gene is overexpressed in Breast (26.4) and Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRE5 Gene



mRNA Expression by UniProt/SwissProt for ADGRE5 Gene

P48960-CD97_HUMAN
Tissue specificity: Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid
genes like me logo Genes that share expression patterns with ADGRE5: view

Protein tissue co-expression partners for ADGRE5 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADGRE5 Gene

Orthologs for ADGRE5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD97 35
  • 77.62 (n)
  • 67.82 (a)
CD97 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD97 35
  • 78.67 (n)
  • 68.98 (a)
CD97 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd97 35
  • 70 (n)
  • 61.17 (a)
Cd97 16
Cd97 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD97 35
  • 91.94 (n)
  • 89.93 (a)
CD97 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd97 35
  • 70.39 (n)
  • 60.98 (a)
oppossum
(Monodelphis domestica)
Mammalia CD97 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD97 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD97 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd97 35
  • 51.09 (n)
  • 42.71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536657 35
  • 50.8 (n)
  • 42.09 (a)
CABZ01066772.1 36
  • 34 (a)
OneToMany
CD97 (1 of 4) 36
  • 33 (a)
OneToMany
CD97 (2 of 4) 36
  • 32 (a)
OneToMany
CD97 (4 of 4) 36
  • 29 (a)
OneToMany
Species with no ortholog for ADGRE5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE5 Gene

ENSEMBL:
Gene Tree for ADGRE5 (if available)
TreeFam:
Gene Tree for ADGRE5 (if available)

Paralogs for ADGRE5 Gene

genes like me logo Genes that share paralogs with ADGRE5: view

Variants for ADGRE5 Gene

Sequence variations from dbSNP and Humsavar for ADGRE5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs111906748 -- 14,386,624(+) GGGAG(A/G)CGGAG intron-variant
rs111896493 -- 14,381,256(+) CTTAC(-/TGAG)TGAGT utr-variant-5-prime, upstream-variant-2KB
rs111717059 -- 14,402,363(+) CTGGG(C/G)AGTGG intron-variant
rs111615417 -- 14,381,266(+) TGCAC(A/G)TGTGT utr-variant-5-prime, upstream-variant-2KB
rs111613337 -- 14,396,960(+) CGGCA(C/T)GTGCA intron-variant

Variation tolerance for ADGRE5 Gene

Residual Variation Intolerance Score: 87.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRE5 Gene

HapMap Linkage Disequilibrium report
ADGRE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRE5 Gene

Disorders for ADGRE5 Gene

Relevant External Links for ADGRE5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRE5
genes like me logo Genes that share disorders with ADGRE5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE5 Gene

Publications for ADGRE5 Gene

  1. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. (PMID: 8786105) Hamann J. … van Lier R.A.W. (Genomics 1996) 2 23 67
  2. Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. (PMID: 7636245) Hamann J. … van Lier R.A.W. (J. Immunol. 1995) 2 23 67
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 67
  4. Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease. (PMID: 20167235) van Eijk M. … Hamann J. (Immunol. Lett. 2010) 23 67
  5. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. (PMID: 20339853) Han S.L. … Zeng Q.Q. (Int J Colorectal Dis 2010) 23 67

Products for ADGRE5 Gene

Sources for ADGRE5 Gene

Back to Top

Content